Re:Search - Details

A Novel Treatment for Malarial Infections

SUBMISSION ID 622

Contact Details

Provider NIH
Partnership Hub Coordinator Name BIO Ventures for Global Health
401 Terry Avenue North
Seattle, WA 98109
USA
Tel: +1 206 732 2122
info@bvgh.org

Submission Summary

TitleA Novel Treatment for Malarial Infections
Executive Summary/Abstract The inventions include antimalarial small molecule inhibitors of the plasmodial surface anion channel (PSAC), an essential nutrient acquisition ion channel expressed on human erythrocytes infected with malaria parasites. These inhibitors were discovered by high-throughput screening of chemical libraries and analysis of their ability to kill malaria parasites in culture. Two separate classes of inhibitors were found to work synergistically in combination against PSAC and killed malaria cultures at markedly lower concentrations than separately. These inhibitors have high affinity and specificity for PSAC and have acceptable cytotoxicity profiles. Preliminary in vivo testing of these compounds in a mouse malaria model is ongoing.
Keywords plasmodial surface anion channel; inhibitors; antimalarial; PSAC

Disease Selection

Disease Malaria
Comment
Name(s) of Infectious Organism(s) Plasmodium falciparum
Vector(s)
Human Target Organ(s)
Mechanism of Action (MoA)
Molecular or Cellular Target Name(s)

Type of Data

Type of Data Intellectual Property







INTELLECTUAL PROPERTY DATA SUBFIELDS

IP Description

 
Summary/Abstract Text The inventions include antimalarial small molecule inhibitors of the plasmodial surface anion channel PSAC , an essential nutrient acquisition ion channel expressed on human erythrocytes infected with malaria parasites. These inhibitors were discovered by high-throughput screening of chemical libraries and analysis of their ability to kill malaria parasites in culture. Two separate classes of inhibitors were found to work synergistically in combination against PSAC and killed malaria cultures at markedly lower concentrations than separately. These inhibitors have high affinity and specificity for PSAC and have acceptable cytotoxicity profiles. Preliminary in vivo testing of these compounds in a mouse malaria model is ongoing.
Keywords
References 1. M Kang, G Lisk, S Hollingworth, SM Baylor, SA Desai. Malaria parasites are rapidly killed by dantrolene derivatives specific for the plasmodial surface anion channel. Mol. Pharmacol. 2005 Jul; 68 1 :34-40. [PubMed abs] 2. SA Desai, SM Bezrukov, J Zimme

Benefits for Disease

 
Field(s) of IP/Know-how Application
How to use IP/Know-how for Disease
Potential Benefits for Disease Application

Publication/Patent Status

 
Proprietary IP or Know-How Yes
How many Patent Families 1.0
How many Granted Patents 0.0
Granted Patent Reference Number(s)
How many Pending Patents 1.0
Pending Patent Reference Number(s) HHS Reference No. E-202-2008/0; EP Application No. 09790437.9; CN Application No. 200980137435.8; BR Application No. _____; AU Application No. 2009274255; CA Application No. 2,731,224; PCT Application No. PCT/US09/50637, filed 07/15/2009; IN Applic
How many Abandoned Patents 0.0
Abandoned Patent Reference Number(s)

Collaboration Status

 
In house only Yes