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TCAMS (Tres Cantos Antimalarial Set)

SUBMISSION ID 464

Contact Details

Provider GlaxoSmithKline - GSK
Partnership Hub Coordinator Name BIO Ventures for Global Health
401 Terry Avenue North
Seattle, WA 98109
USA
Tel: +1 206 732 2122
info@bvgh.org

Submission Summary

TitleTCAMS (Tres Cantos Antimalarial Set)
Executive Summary/Abstract Activity against P. falciparum
Keywords Plasmodium; malaria; inhibitors

Disease Selection

Disease Malaria
Comment
Name(s) of Infectious Organism(s) Plasmodium falciparum
Vector(s) Anopheles mosquito
Human Target Organ(s)
Mechanism of Action (MoA)
Molecular or Cellular Target Name(s) whole-cell target

Type of Data

Type of Data Screening or Hits Data












SCREENING OR HITS DATA SUBFIELDS

Screening/Reporter Assay(s) Description

 
Target Based No
Cell based No
Whole Organism Yes: P. falciparum growth using LDH as surrogate
Parasite clearance No
Other Mechanism of Action (MoA) No
Other Reporter System No

Compound Library Description

 
Small Molecules yes
Natural Extracts
Peptides
Subset Library
Other

Screening Format

 
Screening Format 384 wells

High Content Screening

 
High Content Screening

HTS Throughput

 
HTS Throughput High (10'000 - 100'000 cpd/day)

Screening Campaign Details

 
Screening Campaign Details
Number of Compounds Screened 1986056.0
Cut-off value >80% inhibition at 2 uM
Primary Hit Rate (in %) 9.79
Confirmed Hit Rate (in %) 6.81
Number of Confirmed Hits 13533.0
Number of Screens with Positive Data
Number of Screens with Negative Data

Hits Potency/Efficacy Description

 
<1 µM How many Confirmed Hits 11086.0
<10 µM How many Confirmed Hits
<100 µM How many Confirmed Hits

Collaboration Status

 
In house only Yes

Publication/Patent Status

 
Proprietary Data Yes
Publicly available Data (Reference) https://www.ebi.ac.uk/chemblntd; Nature 2010, 465, 305-310
Patented Data (Reference)