                         SEQUENCE LISTING

<110>  UNIVERSITY OF VIRGINIA PATENT FOUNDATION
       Petri, William A. Jr.
       Carpenter, Rebecca Marie
       Letteri, Rachel
       Feldman, Sanford H.
       Natale, Nicholas R.
 
<120>  REPRESSED ANG 1-7 IN COVID-19 IS INVERSELY ASSOCIATED WITH 
       INFLAMMATION AND COAGULATION

<130>  3062/157 PCT

<150>  US 63/188,927
<151>  2021-05-14

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized Ang 1-7 peptide sequence

<400>  1

Asp Arg Val Tyr Ile His Pro 
1               5           


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized Ang 1-7 peptide sequence

<400>  2

Asp Arg Val Ser Ile His Cys 
1               5           


<210>  3
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized Ang 1-7 peptide sequence

<400>  3

Ala Arg Val Ser Ile His Cys 
1               5           


<210>  4
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized oligonucleotide sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  The nucleotide at the 5' end is optionally labeled with a FAM 
       moiety

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  y = t/u or c

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  The nucleotide at the 3' end is optionally labeled with a BHQ1 
       moiety

<400>  4
aycacattgg cacccgcaat cctg                                              24


<210>  5
<211>  3596
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (307)..(2724)

<400>  5
ggcactcata catacactct ggcaatgagg acactgagct cgcttctgaa atttgacaag       60

ataaccacta aaatctcttt gaattctatg ttgttgtgat cccatggcta cagaggatca      120

ggagttgaca tagatactct ttggatttca taccatgtgg aggctttctt acttccacgt      180

gaccttgact gagttttgaa tagcgcccaa cccaagttca aaggctgata agagagaaaa      240

tctcatgagg aggttttagt ctagggaaag tcattcagtg gatgtgatct tggctcacag      300

gggacg atg tca agc tct tcc tgg ctc ctt ctc agc ctt gtt gct gta         348
       Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val            
       1               5                   10                             

act gct gct cag tcc acc att gag gaa cag gcc aag aca ttt ttg gac        396
Thr Ala Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp           
15                  20                  25                  30            

aag ttt aac cac gaa gcc gaa gac ctg ttc tat caa agt tca ctt gct        444
Lys Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala           
                35                  40                  45                

tct tgg aat tat aac acc aat att act gaa gag aat gtc caa aac atg        492
Ser Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met           
            50                  55                  60                    

aat aat gct ggg gac aaa tgg tct gcc ttt tta aag gaa cag tcc aca        540
Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr           
        65                  70                  75                        

ctt gcc caa atg tat cca cta caa gaa att cag aat ctc aca gtc aag        588
Leu Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys           
    80                  85                  90                            

ctt cag ctg cag gct ctt cag caa aat ggg tct tca gtg ctc tca gaa        636
Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu           
95                  100                 105                 110           

gac aag agc aaa cgg ttg aac aca att cta aat aca atg agc acc atc        684
Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile           
                115                 120                 125               

tac agt act gga aaa gtt tgt aac cca gat aat cca caa gaa tgc tta        732
Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu           
            130                 135                 140                   

tta ctt gaa cca ggt ttg aat gaa ata atg gca aac agt tta gac tac        780
Leu Leu Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr           
        145                 150                 155                       

aat gag agg ctc tgg gct tgg gaa agc tgg aga tct gag gtc ggc aag        828
Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys           
    160                 165                 170                           

cag ctg agg cca tta tat gaa gag tat gtg gtc ttg aaa aat gag atg        876
Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met           
175                 180                 185                 190           

gca aga gca aat cat tat gag gac tat ggg gat tat tgg aga gga gac        924
Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp           
                195                 200                 205               

tat gaa gta aat ggg gta gat ggc tat gac tac agc cgc ggc cag ttg        972
Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu           
            210                 215                 220                   

att gaa gat gtg gaa cat acc ttt gaa gag att aaa cca tta tat gaa       1020
Ile Glu Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu           
        225                 230                 235                       

cat ctt cat gcc tat gtg agg gca aag ttg atg aat gcc tat cct tcc       1068
His Leu His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser           
    240                 245                 250                           

tat atc agt cca att gga tgc ctc cct gct cat ttg ctt ggt gat atg       1116
Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met           
255                 260                 265                 270           

tgg ggt aga ttt tgg aca aat ctg tac tct ttg aca gtt ccc ttt gga       1164
Trp Gly Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly           
                275                 280                 285               

cag aaa cca aac ata gat gtt act gat gca atg gtg gac cag gcc tgg       1212
Gln Lys Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp           
            290                 295                 300                   

gat gca cag aga ata ttc aag gag gcc gag aag ttc ttt gta tct gtt       1260
Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val           
        305                 310                 315                       

ggt ctt cct aat atg act caa gga ttc tgg gaa aat tcc atg cta acg       1308
Gly Leu Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr           
    320                 325                 330                           

gac cca gga aat gtt cag aaa gca gtc tgc cat ccc aca gct tgg gac       1356
Asp Pro Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp           
335                 340                 345                 350           

ctg ggg aag ggc gac ttc agg atc ctt atg tgc aca aag gtg aca atg       1404
Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met           
                355                 360                 365               

gac gac ttc ctg aca gct cat cat gag atg ggg cat atc cag tat gat       1452
Asp Asp Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp           
            370                 375                 380                   

atg gca tat gct gca caa cct ttt ctg cta aga aat gga gct aat gaa       1500
Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu           
        385                 390                 395                       

gga ttc cat gaa gct gtt ggg gaa atc atg tca ctt tct gca gcc aca       1548
Gly Phe His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr           
    400                 405                 410                           

cct aag cat tta aaa tcc att ggt ctt ctg tca ccc gat ttt caa gaa       1596
Pro Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu           
415                 420                 425                 430           

gac aat gaa aca gaa ata aac ttc ctg ctc aaa caa gca ctc acg att       1644
Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile           
                435                 440                 445               

gtt ggg act ctg cca ttt act tac atg tta gag aag tgg agg tgg atg       1692
Val Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met           
            450                 455                 460                   

gtc ttt aaa ggg gaa att ccc aaa gac cag tgg atg aaa aag tgg tgg       1740
Val Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp           
        465                 470                 475                       

gag atg aag cga gag ata gtt ggg gtg gtg gaa cct gtg ccc cat gat       1788
Glu Met Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp           
    480                 485                 490                           

gaa aca tac tgt gac ccc gca tct ctg ttc cat gtt tct aat gat tac       1836
Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr           
495                 500                 505                 510           

tca ttc att cga tat tac aca agg acc ctt tac caa ttc cag ttt caa       1884
Ser Phe Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln           
                515                 520                 525               

gaa gca ctt tgt caa gca gct aaa cat gaa ggc cct ctg cac aaa tgt       1932
Glu Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys           
            530                 535                 540                   

gac atc tca aac tct aca gaa gct gga cag aaa ctg ttc aat atg ctg       1980
Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu           
        545                 550                 555                       

agg ctt gga aaa tca gaa ccc tgg acc cta gca ttg gaa aat gtt gta       2028
Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val           
    560                 565                 570                           

gga gca aag aac atg aat gta agg cca ctg ctc aac tac ttt gag ccc       2076
Gly Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro           
575                 580                 585                 590           

tta ttt acc tgg ctg aaa gac cag aac aag aat tct ttt gtg gga tgg       2124
Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp           
                595                 600                 605               

agt acc gac tgg agt cca tat gca gac caa agc atc aaa gtg agg ata       2172
Ser Thr Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile           
            610                 615                 620                   

agc cta aaa tca gct ctt gga gat aaa gca tat gaa tgg aac gac aat       2220
Ser Leu Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn           
        625                 630                 635                       

gaa atg tac ctg ttc cga tca tct gtt gca tat gct atg agg cag tac       2268
Glu Met Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr           
    640                 645                 650                           

ttt tta aaa gta aaa aat cag atg att ctt ttt ggg gag gag gat gtg       2316
Phe Leu Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val           
655                 660                 665                 670           

cga gtg gct aat ttg aaa cca aga atc tcc ttt aat ttc ttt gtc act       2364
Arg Val Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr           
                675                 680                 685               

gca cct aaa aat gtg tct gat atc att cct aga act gaa gtt gaa aag       2412
Ala Pro Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys           
            690                 695                 700                   

gcc atc agg atg tcc cgg agc cgt atc aat gat gct ttc cgt ctg aat       2460
Ala Ile Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn           
        705                 710                 715                       

gac aac agc cta gag ttt ctg ggg ata cag cca aca ctt gga cct cct       2508
Asp Asn Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro           
    720                 725                 730                           

aac cag ccc cct gtt tcc ata tgg ctg att gtt ttt gga gtt gtg atg       2556
Asn Gln Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met           
735                 740                 745                 750           

gga gtg ata gtg gtt ggc att gtc atc ctg atc ttc act ggg atc aga       2604
Gly Val Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg           
                755                 760                 765               

gat cgg aag aag aaa aat aaa gca aga agt gga gaa aat cct tat gcc       2652
Asp Arg Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala           
            770                 775                 780                   

tcc atc gat att agc aaa gga gaa aat aat cca gga ttc caa aac act       2700
Ser Ile Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr           
        785                 790                 795                       

gat gat gtt cag acc tcc ttt tag aaaaatctat gtttttcctc ttgaggtgat      2754
Asp Asp Val Gln Thr Ser Phe                                               
    800                 805                                               

tttgttgtat gtaaatgtta atttcatggt atagaaaata taagatgata aagatatcat     2814

taaatgtcaa aactatgact ctgttcagaa aaaaaattgt ccaaagacaa catggccaag     2874

gagagagcat cttcattgac attgctttca gtatttattt ctgtctctgg atttgacttc     2934

tgttctgttt cttaataagg attttgtatt agagtatatt agggaaagtg tgtatttggt     2994

ctcacaggct gttcagggat aatctaaatg taaatgtctg ttgaatttct gaagttgaaa     3054

acaaggatat atcattggag caagtgttgg atcttgtatg gaatatggat ggatcacttg     3114

taaggacagt gcctgggaac tggtgtagct gcaaggattg agaatggcat gcattagctc     3174

actttcattt aatccattgt caaggatgac atgctttctt cacagtaact cagttcaagt     3234

actatggtga tttgcctaca gtgatgtttg gaatcgatca tgctttcttc aaggtgacag     3294

gtctaaagag agaagaatcc agggaacagg tagaggacat tgctttttca cttccaaggt     3354

gcttgatcaa catctccctg acaacacaaa actagagcca ggggcctccg tgaactccca     3414

gagcatgcct gatagaaact catttctact gttctctaac tgtggagtga atggaaattc     3474

caactgtatg ttcaccctct gaagtgggta cccagtctct taaatctttt gtatttgctc     3534

acagtgtttg agcagtgctg agcacaaagc agacactcaa taaatgctag atttacacac     3594

tc                                                                    3596


<210>  6
<211>  805
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  7
<211>  3339
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (50)..(2467)

<400>  7
agtctaggga aagtcattca gtggatgtga tcttggctca caggggacg atg tca agc       58
                                                      Met Ser Ser         
                                                      1                   

tct tcc tgg ctc ctt ctc agc ctt gtt gct gta act gct gct cag tcc        106
Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala Ala Gln Ser           
    5                   10                  15                            

acc att gag gaa cag gcc aag aca ttt ttg gac aag ttt aac cac gaa        154
Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu           
20                  25                  30                  35            

gcc gaa gac ctg ttc tat caa agt tca ctt gct tct tgg aat tat aac        202
Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn           
                40                  45                  50                

acc aat att act gaa gag aat gtc caa aac atg aat aat gct ggg gac        250
Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp           
            55                  60                  65                    

aaa tgg tct gcc ttt tta aag gaa cag tcc aca ctt gcc caa atg tat        298
Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr           
        70                  75                  80                        

cca cta caa gaa att cag aat ctc aca gtc aag ctt cag ctg cag gct        346
Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala           
    85                  90                  95                            

ctt cag caa aat ggg tct tca gtg ctc tca gaa gac aag agc aaa cgg        394
Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg           
100                 105                 110                 115           

ttg aac aca att cta aat aca atg agc acc atc tac agt act gga aaa        442
Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys           
                120                 125                 130               

gtt tgt aac cca gat aat cca caa gaa tgc tta tta ctt gaa cca ggt        490
Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly           
            135                 140                 145                   

ttg aat gaa ata atg gca aac agt tta gac tac aat gag agg ctc tgg        538
Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp           
        150                 155                 160                       

gct tgg gaa agc tgg aga tct gag gtc ggc aag cag ctg agg cca tta        586
Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu           
    165                 170                 175                           

tat gaa gag tat gtg gtc ttg aaa aat gag atg gca aga gca aat cat        634
Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His           
180                 185                 190                 195           

tat gag gac tat ggg gat tat tgg aga gga gac tat gaa gta aat ggg        682
Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly           
                200                 205                 210               

gta gat ggc tat gac tac agc cgc ggc cag ttg att gaa gat gtg gaa        730
Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu           
            215                 220                 225                   

cat acc ttt gaa gag att aaa cca tta tat gaa cat ctt cat gcc tat        778
His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr           
        230                 235                 240                       

gtg agg gca aag ttg atg aat gcc tat cct tcc tat atc agt cca att        826
Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile           
    245                 250                 255                           

gga tgc ctc cct gct cat ttg ctt ggt gat atg tgg ggt aga ttt tgg        874
Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp           
260                 265                 270                 275           

aca aat ctg tac tct ttg aca gtt ccc ttt gga cag aaa cca aac ata        922
Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile           
                280                 285                 290               

gat gtt act gat gca atg gtg gac cag gcc tgg gat gca cag aga ata        970
Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile           
            295                 300                 305                   

ttc aag gag gcc gag aag ttc ttt gta tct gtt ggt ctt cct aat atg       1018
Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met           
        310                 315                 320                       

act caa gga ttc tgg gaa aat tcc atg cta acg gac cca gga aat gtt       1066
Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val           
    325                 330                 335                           

cag aaa gca gtc tgc cat ccc aca gct tgg gac ctg ggg aag ggc gac       1114
Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp           
340                 345                 350                 355           

ttc agg atc ctt atg tgc aca aag gtg aca atg gac gac ttc ctg aca       1162
Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr           
                360                 365                 370               

gct cat cat gag atg ggg cat atc cag tat gat atg gca tat gct gca       1210
Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala           
            375                 380                 385                   

caa cct ttt ctg cta aga aat gga gct aat gaa gga ttc cat gaa gct       1258
Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala           
        390                 395                 400                       

gtt ggg gaa atc atg tca ctt tct gca gcc aca cct aag cat tta aaa       1306
Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys           
    405                 410                 415                           

tcc att ggt ctt ctg tca ccc gat ttt caa gaa gac aat gaa aca gaa       1354
Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu           
420                 425                 430                 435           

ata aac ttc ctg ctc aaa caa gca ctc acg att gtt ggg act ctg cca       1402
Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro           
                440                 445                 450               

ttt act tac atg tta gag aag tgg agg tgg atg gtc ttt aaa ggg gaa       1450
Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu           
            455                 460                 465                   

att ccc aaa gac cag tgg atg aaa aag tgg tgg gag atg aag cga gag       1498
Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu           
        470                 475                 480                       

ata gtt ggg gtg gtg gaa cct gtg ccc cat gat gaa aca tac tgt gac       1546
Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp           
    485                 490                 495                           

ccc gca tct ctg ttc cat gtt tct aat gat tac tca ttc att cga tat       1594
Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr           
500                 505                 510                 515           

tac aca agg acc ctt tac caa ttc cag ttt caa gaa gca ctt tgt caa       1642
Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln           
                520                 525                 530               

gca gct aaa cat gaa ggc cct ctg cac aaa tgt gac atc tca aac tct       1690
Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser           
            535                 540                 545                   

aca gaa gct gga cag aaa ctg ttc aat atg ctg agg ctt gga aaa tca       1738
Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser           
        550                 555                 560                       

gaa ccc tgg acc cta gca ttg gaa aat gtt gta gga gca aag aac atg       1786
Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met           
    565                 570                 575                           

aat gta agg cca ctg ctc aac tac ttt gag ccc tta ttt acc tgg ctg       1834
Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu           
580                 585                 590                 595           

aaa gac cag aac aag aat tct ttt gtg gga tgg agt acc gac tgg agt       1882
Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser           
                600                 605                 610               

cca tat gca gac caa agc atc aaa gtg agg ata agc cta aaa tca gct       1930
Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu Lys Ser Ala           
            615                 620                 625                   

ctt gga gat aaa gca tat gaa tgg aac gac aat gaa atg tac ctg ttc       1978
Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met Tyr Leu Phe           
        630                 635                 640                       

cga tca tct gtt gca tat gct atg agg cag tac ttt tta aaa gta aaa       2026
Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu Lys Val Lys           
    645                 650                 655                           

aat cag atg att ctt ttt ggg gag gag gat gtg cga gtg gct aat ttg       2074
Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val Ala Asn Leu           
660                 665                 670                 675           

aaa cca aga atc tcc ttt aat ttc ttt gtc act gca cct aaa aat gtg       2122
Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro Lys Asn Val           
                680                 685                 690               

tct gat atc att cct aga act gaa gtt gaa aag gcc atc agg atg tcc       2170
Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile Arg Met Ser           
            695                 700                 705                   

cgg agc cgt atc aat gat gct ttc cgt ctg aat gac aac agc cta gag       2218
Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn Ser Leu Glu           
        710                 715                 720                       

ttt ctg ggg ata cag cca aca ctt gga cct cct aac cag ccc cct gtt       2266
Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln Pro Pro Val           
    725                 730                 735                           

tcc ata tgg ctg att gtt ttt gga gtt gtg atg gga gtg ata gtg gtt       2314
Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val Ile Val Val           
740                 745                 750                 755           

ggc att gtc atc ctg atc ttc act ggg atc aga gat cgg aag aag aaa       2362
Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg Lys Lys Lys           
                760                 765                 770               

aat aaa gca aga agt gga gaa aat cct tat gcc tcc atc gat att agc       2410
Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile Asp Ile Ser           
            775                 780                 785                   

aaa gga gaa aat aat cca gga ttc caa aac act gat gat gtt cag acc       2458
Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp Val Gln Thr           
        790                 795                 800                       

tcc ttt tag aaaaatctat gtttttcctc ttgaggtgat tttgttgtat               2507
Ser Phe                                                                   
    805                                                                   

gtaaatgtta atttcatggt atagaaaata taagatgata aagatatcat taaatgtcaa     2567

aactatgact ctgttcagaa aaaaaattgt ccaaagacaa catggccaag gagagagcat     2627

cttcattgac attgctttca gtatttattt ctgtctctgg atttgacttc tgttctgttt     2687

cttaataagg attttgtatt agagtatatt agggaaagtg tgtatttggt ctcacaggct     2747

gttcagggat aatctaaatg taaatgtctg ttgaatttct gaagttgaaa acaaggatat     2807

atcattggag caagtgttgg atcttgtatg gaatatggat ggatcacttg taaggacagt     2867

gcctgggaac tggtgtagct gcaaggattg agaatggcat gcattagctc actttcattt     2927

aatccattgt caaggatgac atgctttctt cacagtaact cagttcaagt actatggtga     2987

tttgcctaca gtgatgtttg gaatcgatca tgctttcttc aaggtgacag gtctaaagag     3047

agaagaatcc agggaacagg tagaggacat tgctttttca cttccaaggt gcttgatcaa     3107

catctccctg acaacacaaa actagagcca ggggcctccg tgaactccca gagcatgcct     3167

gatagaaact catttctact gttctctaac tgtggagtga atggaaattc caactgtatg     3227

ttcaccctct gaagtgggta cccagtctct taaatctttt gtatttgctc acagtgtttg     3287

agcagtgctg agcacaaagc agacactcaa taaatgctag atttacacac tc             3339


<210>  8
<211>  805
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  9
<211>  3141
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (50)..(2410)

<400>  9
agtctaggga aagtcattca gtggatgtga tcttggctca caggggacg atg tca agc       58
                                                      Met Ser Ser         
                                                      1                   

tct tcc tgg ctc ctt ctc agc ctt gtt gct gta act gct gct cag tcc        106
Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala Ala Gln Ser           
    5                   10                  15                            

acc att gag gaa cag gcc aag aca ttt ttg gac aag ttt aac cac gaa        154
Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu           
20                  25                  30                  35            

gcc gaa gac ctg ttc tat caa agt tca ctt gct tct tgg aat tat aac        202
Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn           
                40                  45                  50                

acc aat att act gaa gag aat gtc caa aac atg aat aat gct ggg gac        250
Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp           
            55                  60                  65                    

aaa tgg tct gcc ttt tta aag gaa cag tcc aca ctt gcc caa atg tat        298
Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr           
        70                  75                  80                        

cca cta caa gaa att cag aat ctc aca gtc aag ctt cag ctg cag gct        346
Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala           
    85                  90                  95                            

ctt cag caa aat ggg tct tca gtg ctc tca gaa gac aag agc aaa cgg        394
Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg           
100                 105                 110                 115           

ttg aac aca att cta aat aca atg agc acc atc tac agt act gga aaa        442
Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys           
                120                 125                 130               

gtt tgt aac cca gat aat cca caa gaa tgc tta tta ctt gaa cca ggt        490
Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly           
            135                 140                 145                   

ttg aat gaa ata atg gca aac agt tta gac tac aat gag agg ctc tgg        538
Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp           
        150                 155                 160                       

gct tgg gaa agc tgg aga tct gag gtc ggc aag cag ctg agg cca tta        586
Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu           
    165                 170                 175                           

tat gaa gag tat gtg gtc ttg aaa aat gag atg gca aga gca aat cat        634
Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His           
180                 185                 190                 195           

tat gag gac tat ggg gat tat tgg aga gga gac tat gaa gta aat ggg        682
Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly           
                200                 205                 210               

gta gat ggc tat gac tac agc cgc ggc cag ttg att gaa gat gtg gaa        730
Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu           
            215                 220                 225                   

cat acc ttt gaa gag att aaa cca tta tat gaa cat ctt cat gcc tat        778
His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr           
        230                 235                 240                       

gtg agg gca aag ttg atg aat gcc tat cct tcc tat atc agt cca att        826
Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile           
    245                 250                 255                           

gga tgc ctc cct gct cat ttg ctt ggt gat atg tgg ggt aga ttt tgg        874
Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp           
260                 265                 270                 275           

aca aat ctg tac tct ttg aca gtt ccc ttt gga cag aaa cca aac ata        922
Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile           
                280                 285                 290               

gat gtt act gat gca atg gtg gac cag gcc tgg gat gca cag aga ata        970
Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile           
            295                 300                 305                   

ttc aag gag gcc gag aag ttc ttt gta tct gtt ggt ctt cct aat atg       1018
Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met           
        310                 315                 320                       

act caa gga ttc tgg gaa aat tcc atg cta acg gac cca gga aat gtt       1066
Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val           
    325                 330                 335                           

cag aaa gca gtc tgc cat ccc aca gct tgg gac ctg ggg aag ggc gac       1114
Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp           
340                 345                 350                 355           

ttc agg atc ctt atg tgc aca aag gtg aca atg gac gac ttc ctg aca       1162
Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr           
                360                 365                 370               

gct cat cat gag atg ggg cat atc cag tat gat atg gca tat gct gca       1210
Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala           
            375                 380                 385                   

caa cct ttt ctg cta aga aat gga gct aat gaa gga ttc cat gaa gct       1258
Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala           
        390                 395                 400                       

gtt ggg gaa atc atg tca ctt tct gca gcc aca cct aag cat tta aaa       1306
Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys           
    405                 410                 415                           

tcc att ggt ctt ctg tca ccc gat ttt caa gaa gac aat gaa aca gaa       1354
Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu           
420                 425                 430                 435           

ata aac ttc ctg ctc aaa caa gca ctc acg att gtt ggg act ctg cca       1402
Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro           
                440                 445                 450               

ttt act tac atg tta gag aag tgg agg tgg atg gtc ttt aaa ggg gaa       1450
Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu           
            455                 460                 465                   

att ccc aaa gac cag tgg atg aaa aag tgg tgg gag atg aag cga gag       1498
Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu           
        470                 475                 480                       

ata gtt ggg gtg gtg gaa cct gtg ccc cat gat gaa aca tac tgt gac       1546
Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp           
    485                 490                 495                           

ccc gca tct ctg ttc cat gtt tct aat gat tac tca ttc att cga tat       1594
Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr           
500                 505                 510                 515           

tac aca agg acc ctt tac caa ttc cag ttt caa gaa gca ctt tgt caa       1642
Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln           
                520                 525                 530               

gca gct aaa cat gaa ggc cct ctg cac aaa tgt gac atc tca aac tct       1690
Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser           
            535                 540                 545                   

aca gaa gct gga cag aaa ctg ttc aat atg ctg agg ctt gga aaa tca       1738
Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser           
        550                 555                 560                       

gaa ccc tgg acc cta gca ttg gaa aat gtt gta gga gca aag aac atg       1786
Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met           
    565                 570                 575                           

aat gta agg cca ctg ctc aac tac ttt gag ccc tta ttt acc tgg ctg       1834
Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu           
580                 585                 590                 595           

aaa gac cag aac aag aat tct ttt gtg gga tgg agt acc gac tgg agt       1882
Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser           
                600                 605                 610               

cca tat gca gac caa agc atc aaa gtg agg ata agc cta aaa tca gct       1930
Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu Lys Ser Ala           
            615                 620                 625                   

ctt gga gat aaa gca tat gaa tgg aac gac aat gaa atg tac ctg ttc       1978
Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met Tyr Leu Phe           
        630                 635                 640                       

cga tca tct gtt gca tat gct atg agg cag tac ttt tta aaa gta aaa       2026
Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu Lys Val Lys           
    645                 650                 655                           

aat cag atg att ctt ttt ggg gag gag gat gtg cga gtg gct aat ttg       2074
Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val Ala Asn Leu           
660                 665                 670                 675           

aaa cca aga atc tcc ttt aat ttc ttt gtc act gca cct aaa aat gtg       2122
Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro Lys Asn Val           
                680                 685                 690               

tct gat atc att cct aga act gaa gtt gaa aag gcc atc agg atg tcc       2170
Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile Arg Met Ser           
            695                 700                 705                   

cgg agc cgt atc aat gat gct ttc cgt ctg aat gac aac agc cta gag       2218
Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn Ser Leu Glu           
        710                 715                 720                       

ttt ctg ggg ata cag cca aca ctt gga cct cct aac cag ccc cct gtt       2266
Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln Pro Pro Val           
    725                 730                 735                           

tcc ata tgg ctg att gtt ttt gga gtt gtg atg gga gtg ata gtg gtt       2314
Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val Ile Val Val           
740                 745                 750                 755           

ggc att gtc atc ctg atc ttc act ggg atc aga gat cgg aag aag cca       2362
Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg Lys Lys Pro           
                760                 765                 770               

act cca ctc ttg gga aaa agt tgg ctg aca gcc atc ttg aaa gat tga       2410
Thr Pro Leu Leu Gly Lys Ser Trp Leu Thr Ala Ile Leu Lys Asp               
            775                 780                 785                   

gggctgaaaa tccaagaact gaggatcaag atctctcccc tgtcataaaa ctacatatgg     2470

atctgccctt cagtaggaaa ttcctaaaag tctcccatga gataaagaat cagtgctgga     2530

aaactcactc cgataccacc accaccaaat catgatagaa acagctatgt gtgtcttttt     2590

ttaattagac ctcatcttcc ttggaactaa ctctgaaagg gccatgaatc tcagcccccc     2650

caaaatccct ccccaaaagc atgctgccag gtgatgcagg cccaagctag gtgacagatg     2710

tttaacttgg aatgatgttt gcagtcatgt gataataaca ttggatggaa caattcagag     2770

gctgttctta tgattacaag taatggggac atttttatca tttgagaatg actgcaaaac     2830

tatggaattt ggcaaagact ttatttggaa gcagggaaga aagcccactg aatagctttg     2890

aagggataat ggagggaaag aattatgttg ttttctgctt ttgtcctata gagtttcatt     2950

tcaacaccag gatacttcca caaagcagtc ttggccatgt tgatggtaag gaaagaatga     3010

cagctaataa cagctgcctg ttatgtgtga tgccatctta aggacatctc ccgcatgcac     3070

ccattttttc tttttttttt tttggtgact atttatgggc ttactggcta ggaaaagaca     3130

caacaatgaa a                                                          3141


<210>  10
<211>  786
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Pro Thr Pro Leu Leu Gly Lys Ser Trp Leu Thr Ala Ile Leu 
    770                 775                 780                 


Lys Asp 
785     


<210>  11
<211>  3006
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (50)..(2134)

<400>  11
agtctaggga aagtcattca gtggatgtga tcttggctca caggggacg atg tca agc       58
                                                      Met Ser Ser         
                                                      1                   

tct tcc tgg ctc ctt ctc agc ctt gtt gct gta act gct gct cag tcc        106
Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala Ala Gln Ser           
    5                   10                  15                            

acc att gag gaa cag gcc aag aca ttt ttg gac aag ttt aac cac gaa        154
Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu           
20                  25                  30                  35            

gcc gaa gac ctg ttc tat caa agt tca ctt gct tct tgg aat tat aac        202
Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn           
                40                  45                  50                

acc aat att act gaa gag aat gtc caa aac atg aat aat gct ggg gac        250
Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp           
            55                  60                  65                    

aaa tgg tct gcc ttt tta aag gaa cag tcc aca ctt gcc caa atg tat        298
Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr           
        70                  75                  80                        

cca cta caa gaa att cag aat ctc aca gtc aag ctt cag ctg cag gct        346
Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala           
    85                  90                  95                            

ctt cag caa aat ggg tct tca gtg ctc tca gaa gac aag agc aaa cgg        394
Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg           
100                 105                 110                 115           

ttg aac aca att cta aat aca atg agc acc atc tac agt act gga aaa        442
Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys           
                120                 125                 130               

gtt tgt aac cca gat aat cca caa gaa tgc tta tta ctt gaa cca ggt        490
Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly           
            135                 140                 145                   

ttg aat gaa ata atg gca aac agt tta gac tac aat gag agg ctc tgg        538
Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp           
        150                 155                 160                       

gct tgg gaa agc tgg aga tct gag gtc ggc aag cag ctg agg cca tta        586
Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu           
    165                 170                 175                           

tat gaa gag tat gtg gtc ttg aaa aat gag atg gca aga gca aat cat        634
Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His           
180                 185                 190                 195           

tat gag gac tat ggg gat tat tgg aga gga gac tat gaa gta aat ggg        682
Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly           
                200                 205                 210               

gta gat ggc tat gac tac agc cgc ggc cag ttg att gaa gat gtg gaa        730
Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu           
            215                 220                 225                   

cat acc ttt gaa gag att aaa cca tta tat gaa cat ctt cat gcc tat        778
His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr           
        230                 235                 240                       

gtg agg gca aag ttg atg aat gcc tat cct tcc tat atc agt cca att        826
Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile           
    245                 250                 255                           

gga tgc ctc cct gct cat ttg ctt ggt gat atg tgg ggt aga ttt tgg        874
Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp           
260                 265                 270                 275           

aca aat ctg tac tct ttg aca gtt ccc ttt gga cag aaa cca aac ata        922
Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile           
                280                 285                 290               

gat gtt act gat gca atg gtg gac cag gcc tgg gat gca cag aga ata        970
Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile           
            295                 300                 305                   

ttc aag gag gcc gag aag ttc ttt gta tct gtt ggt ctt cct aat atg       1018
Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met           
        310                 315                 320                       

act caa gga ttc tgg gaa aat tcc atg cta acg gac cca gga aat gtt       1066
Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val           
    325                 330                 335                           

cag aaa gca gtc tgc cat ccc aca gct tgg gac ctg ggg aag ggc gac       1114
Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp           
340                 345                 350                 355           

ttc agg atc ctt atg tgc aca aag gtg aca atg gac gac ttc ctg aca       1162
Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr           
                360                 365                 370               

gct cat cat gag atg ggg cat atc cag tat gat atg gca tat gct gca       1210
Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala           
            375                 380                 385                   

caa cct ttt ctg cta aga aat gga gct aat gaa gga ttc cat gaa gct       1258
Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala           
        390                 395                 400                       

gtt ggg gaa atc atg tca ctt tct gca gcc aca cct aag cat tta aaa       1306
Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys           
    405                 410                 415                           

tcc att ggt ctt ctg tca ccc gat ttt caa gaa gac aat gaa aca gaa       1354
Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu           
420                 425                 430                 435           

ata aac ttc ctg ctc aaa caa gca ctc acg att gtt ggg act ctg cca       1402
Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro           
                440                 445                 450               

ttt act tac atg tta gag aag tgg agg tgg atg gtc ttt aaa ggg gaa       1450
Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu           
            455                 460                 465                   

att ccc aaa gac cag tgg atg aaa aag tgg tgg gag atg aag cga gag       1498
Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu           
        470                 475                 480                       

ata gtt ggg gtg gtg gaa cct gtg ccc cat gat gaa aca tac tgt gac       1546
Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp           
    485                 490                 495                           

ccc gca tct ctg ttc cat gtt tct aat gat tac tca ttc att cga tat       1594
Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr           
500                 505                 510                 515           

tac aca agg acc ctt tac caa ttc cag ttt caa gaa gca ctt tgt caa       1642
Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln           
                520                 525                 530               

gca gct aaa cat gaa ggc cct ctg cac aaa tgt gac atc tca aac tct       1690
Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser           
            535                 540                 545                   

aca gaa gct gga cag aaa ctg ttg gag gag gat gtg cga gtg gct aat       1738
Thr Glu Ala Gly Gln Lys Leu Leu Glu Glu Asp Val Arg Val Ala Asn           
        550                 555                 560                       

ttg aaa cca aga atc tcc ttt aat ttc ttt gtc act gca cct aaa aat       1786
Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro Lys Asn           
    565                 570                 575                           

gtg tct gat atc att cct aga act gaa gtt gaa aag gcc atc agg atg       1834
Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile Arg Met           
580                 585                 590                 595           

tcc cgg agc cgt atc aat gat gct ttc cgt ctg aat gac aac agc cta       1882
Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn Ser Leu           
                600                 605                 610               

gag ttt ctg ggg ata cag cca aca ctt gga cct cct aac cag ccc cct       1930
Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln Pro Pro           
            615                 620                 625                   

gtt tcc ata tgg ctg att gtt ttt gga gtt gtg atg gga gtg ata gtg       1978
Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val Ile Val           
        630                 635                 640                       

gtt ggc att gtc atc ctg atc ttc act ggg atc aga gat cgg aag aag       2026
Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg Lys Lys           
    645                 650                 655                           

aaa aat aaa gca aga agt gga gaa aat cct tat gcc tcc atc gat att       2074
Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile Asp Ile           
660                 665                 670                 675           

agc aaa gga gaa aat aat cca gga ttc caa aac act gat gat gtt cag       2122
Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp Val Gln           
                680                 685                 690               

acc tcc ttt tag aaaaatctat gtttttcctc ttgaggtgat tttgttgtat           2174
Thr Ser Phe                                                               
                                                                          

gtaaatgtta atttcatggt atagaaaata taagatgata aagatatcat taaatgtcaa     2234

aactatgact ctgttcagaa aaaaaattgt ccaaagacaa catggccaag gagagagcat     2294

cttcattgac attgctttca gtatttattt ctgtctctgg atttgacttc tgttctgttt     2354

cttaataagg attttgtatt agagtatatt agggaaagtg tgtatttggt ctcacaggct     2414

gttcagggat aatctaaatg taaatgtctg ttgaatttct gaagttgaaa acaaggatat     2474

atcattggag caagtgttgg atcttgtatg gaatatggat ggatcacttg taaggacagt     2534

gcctgggaac tggtgtagct gcaaggattg agaatggcat gcattagctc actttcattt     2594

aatccattgt caaggatgac atgctttctt cacagtaact cagttcaagt actatggtga     2654

tttgcctaca gtgatgtttg gaatcgatca tgctttcttc aaggtgacag gtctaaagag     2714

agaagaatcc agggaacagg tagaggacat tgctttttca cttccaaggt gcttgatcaa     2774

catctccctg acaacacaaa actagagcca ggggcctccg tgaactccca gagcatgcct     2834

gatagaaact catttctact gttctctaac tgtggagtga atggaaattc caactgtatg     2894

ttcaccctct gaagtgggta cccagtctct taaatctttt gtatttgctc acagtgtttg     2954

agcagtgctg agcacaaagc agacactcaa taaatgctag atttacacac tc             3006


<210>  12
<211>  694
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Leu Glu Glu Asp Val Arg 
545                 550                 555                 560 


Val Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala 
                565                 570                 575     


Pro Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala 
            580                 585                 590         


Ile Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp 
        595                 600                 605             


Asn Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn 
    610                 615                 620                 


Gln Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly 
625                 630                 635                 640 


Val Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp 
                645                 650                 655     


Arg Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser 
            660                 665                 670         


Ile Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp 
        675                 680                 685             


Asp Val Gln Thr Ser Phe 
    690                 


<210>  13
<211>  2360
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (109)..(1488)

<400>  13
gtaattccca ggttgcaggc ttgtgagagc cttaggttgg attccctagc ttgaaaagga       60

gatcgtttta caagtgcttc attgaggaga gctctgaggc agagggga atg agg gaa       117
                                                     Met Arg Glu          
                                                     1                    

gca ggc tgg gac aaa gga ggg agg atc ctt atg tgc aca aag gtg aca        165
Ala Gly Trp Asp Lys Gly Gly Arg Ile Leu Met Cys Thr Lys Val Thr           
    5                   10                  15                            

atg gac gac ttc ctg aca gct cat cat gag atg ggg cat atc cag tat        213
Met Asp Asp Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr           
20                  25                  30                  35            

gat atg gca tat gct gca caa cct ttt ctg cta aga aat gga gct aat        261
Asp Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn           
                40                  45                  50                

gaa gga ttc cat gaa gct gtt ggg gaa atc atg tca ctt tct gca gcc        309
Glu Gly Phe His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala           
            55                  60                  65                    

aca cct aag cat tta aaa tcc att ggt ctt ctg tca ccc gat ttt caa        357
Thr Pro Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln           
        70                  75                  80                        

gaa gac aat gaa aca gaa ata aac ttc ctg ctc aaa caa gca ctc acg        405
Glu Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr           
    85                  90                  95                            

att gtt ggg act ctg cca ttt act tac atg tta gag aag tgg agg tgg        453
Ile Val Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp           
100                 105                 110                 115           

atg gtc ttt aaa ggg gaa att ccc aaa gac cag tgg atg aaa aag tgg        501
Met Val Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp           
                120                 125                 130               

tgg gag atg aag cga gag ata gtt ggg gtg gtg gaa cct gtg ccc cat        549
Trp Glu Met Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His           
            135                 140                 145                   

gat gaa aca tac tgt gac ccc gca tct ctg ttc cat gtt tct aat gat        597
Asp Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp           
        150                 155                 160                       

tac tca ttc att cga tat tac aca agg acc ctt tac caa ttc cag ttt        645
Tyr Ser Phe Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe           
    165                 170                 175                           

caa gaa gca ctt tgt caa gca gct aaa cat gaa ggc cct ctg cac aaa        693
Gln Glu Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys           
180                 185                 190                 195           

tgt gac atc tca aac tct aca gaa gct gga cag aaa ctg ttc aat atg        741
Cys Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met           
                200                 205                 210               

ctg agg ctt gga aaa tca gaa ccc tgg acc cta gca ttg gaa aat gtt        789
Leu Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val           
            215                 220                 225                   

gta gga gca aag aac atg aat gta agg cca ctg ctc aac tac ttt gag        837
Val Gly Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu           
        230                 235                 240                       

ccc tta ttt acc tgg ctg aaa gac cag aac aag aat tct ttt gtg gga        885
Pro Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly           
    245                 250                 255                           

tgg agt acc gac tgg agt cca tat gca gac caa agc atc aaa gtg agg        933
Trp Ser Thr Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg           
260                 265                 270                 275           

ata agc cta aaa tca gct ctt gga gat aaa gca tat gaa tgg aac gac        981
Ile Ser Leu Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp           
                280                 285                 290               

aat gaa atg tac ctg ttc cga tca tct gtt gca tat gct atg agg cag       1029
Asn Glu Met Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln           
            295                 300                 305                   

tac ttt tta aaa gta aaa aat cag atg att ctt ttt ggg gag gag gat       1077
Tyr Phe Leu Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp           
        310                 315                 320                       

gtg cga gtg gct aat ttg aaa cca aga atc tcc ttt aat ttc ttt gtc       1125
Val Arg Val Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val           
    325                 330                 335                           

act gca cct aaa aat gtg tct gat atc att cct aga act gaa gtt gaa       1173
Thr Ala Pro Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu           
340                 345                 350                 355           

aag gcc atc agg atg tcc cgg agc cgt atc aat gat gct ttc cgt ctg       1221
Lys Ala Ile Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu           
                360                 365                 370               

aat gac aac agc cta gag ttt ctg ggg ata cag cca aca ctt gga cct       1269
Asn Asp Asn Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro           
            375                 380                 385                   

cct aac cag ccc cct gtt tcc ata tgg ctg att gtt ttt gga gtt gtg       1317
Pro Asn Gln Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val           
        390                 395                 400                       

atg gga gtg ata gtg gtt ggc att gtc atc ctg atc ttc act ggg atc       1365
Met Gly Val Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile           
    405                 410                 415                           

aga gat cgg aag aag aaa aat aaa gca aga agt gga gaa aat cct tat       1413
Arg Asp Arg Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr           
420                 425                 430                 435           

gcc tcc atc gat att agc aaa gga gaa aat aat cca gga ttc caa aac       1461
Ala Ser Ile Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn           
                440                 445                 450               

act gat gat gtt cag acc tcc ttt tag aaaaatctat gtttttcctc             1508
Thr Asp Asp Val Gln Thr Ser Phe                                           
            455                                                           

ttgaggtgat tttgttgtat gtaaatgtta atttcatggt atagaaaata taagatgata     1568

aagatatcat taaatgtcaa aactatgact ctgttcagaa aaaaaattgt ccaaagacaa     1628

catggccaag gagagagcat cttcattgac attgctttca gtatttattt ctgtctctgg     1688

atttgacttc tgttctgttt cttaataagg attttgtatt agagtatatt agggaaagtg     1748

tgtatttggt ctcacaggct gttcagggat aatctaaatg taaatgtctg ttgaatttct     1808

gaagttgaaa acaaggatat atcattggag caagtgttgg atcttgtatg gaatatggat     1868

ggatcacttg taaggacagt gcctgggaac tggtgtagct gcaaggattg agaatggcat     1928

gcattagctc actttcattt aatccattgt caaggatgac atgctttctt cacagtaact     1988

cagttcaagt actatggtga tttgcctaca gtgatgtttg gaatcgatca tgctttcttc     2048

aaggtgacag gtctaaagag agaagaatcc agggaacagg tagaggacat tgctttttca     2108

cttccaaggt gcttgatcaa catctccctg acaacacaaa actagagcca ggggcctccg     2168

tgaactccca gagcatgcct gatagaaact catttctact gttctctaac tgtggagtga     2228

atggaaattc caactgtatg ttcaccctct gaagtgggta cccagtctct taaatctttt     2288

gtatttgctc acagtgtttg agcagtgctg agcacaaagc agacactcaa taaatgctag     2348

atttacacac tc                                                         2360


<210>  14
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Arg Glu Ala Gly Trp Asp Lys Gly Gly Arg Ile Leu Met Cys Thr 
1               5                   10                  15      


Lys Val Thr Met Asp Asp Phe Leu Thr Ala His His Glu Met Gly His 
            20                  25                  30          


Ile Gln Tyr Asp Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn 
        35                  40                  45              


Gly Ala Asn Glu Gly Phe His Glu Ala Val Gly Glu Ile Met Ser Leu 
    50                  55                  60                  


Ser Ala Ala Thr Pro Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro 
65                  70                  75                  80  


Asp Phe Gln Glu Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln 
                85                  90                  95      


Ala Leu Thr Ile Val Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys 
            100                 105                 110         


Trp Arg Trp Met Val Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met 
        115                 120                 125             


Lys Lys Trp Trp Glu Met Lys Arg Glu Ile Val Gly Val Val Glu Pro 
    130                 135                 140                 


Val Pro His Asp Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe His Val 
145                 150                 155                 160 


Ser Asn Asp Tyr Ser Phe Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln 
                165                 170                 175     


Phe Gln Phe Gln Glu Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro 
            180                 185                 190         


Leu His Lys Cys Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu 
        195                 200                 205             


Phe Asn Met Leu Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu 
    210                 215                 220                 


Glu Asn Val Val Gly Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn 
225                 230                 235                 240 


Tyr Phe Glu Pro Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser 
                245                 250                 255     


Phe Val Gly Trp Ser Thr Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile 
            260                 265                 270         


Lys Val Arg Ile Ser Leu Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu 
        275                 280                 285             


Trp Asn Asp Asn Glu Met Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala 
    290                 295                 300                 


Met Arg Gln Tyr Phe Leu Lys Val Lys Asn Gln Met Ile Leu Phe Gly 
305                 310                 315                 320 


Glu Glu Asp Val Arg Val Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn 
                325                 330                 335     


Phe Phe Val Thr Ala Pro Lys Asn Val Ser Asp Ile Ile Pro Arg Thr 
            340                 345                 350         


Glu Val Glu Lys Ala Ile Arg Met Ser Arg Ser Arg Ile Asn Asp Ala 
        355                 360                 365             


Phe Arg Leu Asn Asp Asn Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr 
    370                 375                 380                 


Leu Gly Pro Pro Asn Gln Pro Pro Val Ser Ile Trp Leu Ile Val Phe 
385                 390                 395                 400 


Gly Val Val Met Gly Val Ile Val Val Gly Ile Val Ile Leu Ile Phe 
                405                 410                 415     


Thr Gly Ile Arg Asp Arg Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu 
            420                 425                 430         


Asn Pro Tyr Ala Ser Ile Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly 
        435                 440                 445             


Phe Gln Asn Thr Asp Asp Val Gln Thr Ser Phe 
    450                 455                 


<210>  15
<211>  3135
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (179)..(2263)

<400>  15
ttagaacttt ttaaaagagg caaaggcaga ggagaacaaa ggaaggagga agtaacttgt       60

ggaatgttga gaaagcgccc aacccaagtt caaaggctga taagagagaa aatctcatga      120

ggaggtttta gtctagggaa agtcattcag tggatgtgat cttggctcac aggggacg        178

atg tca agc tct tcc tgg ctc ctt ctc agc ctt gtt gct gta act gct        226
Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala           
1               5                   10                  15                

gct cag tcc acc att gag gaa cag gcc aag aca ttt ttg gac aag ttt        274
Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe           
            20                  25                  30                    

aac cac gaa gcc gaa gac ctg ttc tat caa agt tca ctt gct tct tgg        322
Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp           
        35                  40                  45                        

aat tat aac acc aat att act gaa gag aat gtc caa aac atg aat aat        370
Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn           
    50                  55                  60                            

gct ggg gac aaa tgg tct gcc ttt tta aag gaa cag tcc aca ctt gcc        418
Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala           
65                  70                  75                  80            

caa atg tat cca cta caa gaa att cag aat ctc aca gtc aag ctt cag        466
Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln           
                85                  90                  95                

ctg cag gct ctt cag caa aat ggg tct tca gtg ctc tca gaa gac aag        514
Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys           
            100                 105                 110                   

agc aaa cgg ttg aac aca att cta aat aca atg agc acc atc tac agt        562
Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser           
        115                 120                 125                       

act gga aaa gtt tgt aac cca gat aat cca caa gaa tgc tta tta ctt        610
Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu           
    130                 135                 140                           

gaa cca ggt ttg aat gaa ata atg gca aac agt tta gac tac aat gag        658
Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu           
145                 150                 155                 160           

agg ctc tgg gct tgg gaa agc tgg aga tct gag gtc ggc aag cag ctg        706
Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu           
                165                 170                 175               

agg cca tta tat gaa gag tat gtg gtc ttg aaa aat gag atg gca aga        754
Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg           
            180                 185                 190                   

gca aat cat tat gag gac tat ggg gat tat tgg aga gga gac tat gaa        802
Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu           
        195                 200                 205                       

gta aat ggg gta gat ggc tat gac tac agc cgc ggc cag ttg att gaa        850
Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu           
    210                 215                 220                           

gat gtg gaa cat acc ttt gaa gag att aaa cca tta tat gaa cat ctt        898
Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu           
225                 230                 235                 240           

cat gcc tat gtg agg gca aag ttg atg aat gcc tat cct tcc tat atc        946
His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile           
                245                 250                 255               

agt cca att gga tgc ctc cct gct cat ttg ctt ggt gat atg tgg ggt        994
Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly           
            260                 265                 270                   

aga ttt tgg aca aat ctg tac tct ttg aca gtt ccc ttt gga cag aaa       1042
Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys           
        275                 280                 285                       

cca aac ata gat gtt act gat gca atg gtg gac cag gcc tgg gat gca       1090
Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala           
    290                 295                 300                           

cag aga ata ttc aag gag gcc gag aag ttc ttt gta tct gtt ggt ctt       1138
Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu           
305                 310                 315                 320           

cct aat atg act caa gga ttc tgg gaa aat tcc atg cta acg gac cca       1186
Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro           
                325                 330                 335               

gga aat gtt cag aaa gca gtc tgc cat ccc aca gct tgg gac ctg ggg       1234
Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly           
            340                 345                 350                   

aag ggc gac ttc agg atc ctt atg tgc aca aag gtg aca atg gac gac       1282
Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp           
        355                 360                 365                       

ttc ctg aca gct cat cat gag atg ggg cat atc cag tat gat atg gca       1330
Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala           
    370                 375                 380                           

tat gct gca caa cct ttt ctg cta aga aat gga gct aat gaa gga ttc       1378
Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe           
385                 390                 395                 400           

cat gaa gct gtt ggg gaa atc atg tca ctt tct gca gcc aca cct aag       1426
His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys           
                405                 410                 415               

cat tta aaa tcc att ggt ctt ctg tca ccc gat ttt caa gaa gac aat       1474
His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn           
            420                 425                 430                   

gaa aca gaa ata aac ttc ctg ctc aaa caa gca ctc acg att gtt ggg       1522
Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly           
        435                 440                 445                       

act ctg cca ttt act tac atg tta gag aag tgg agg tgg atg gtc ttt       1570
Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe           
    450                 455                 460                           

aaa ggg gaa att ccc aaa gac cag tgg atg aaa aag tgg tgg gag atg       1618
Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met           
465                 470                 475                 480           

aag cga gag ata gtt ggg gtg gtg gaa cct gtg ccc cat gat gaa aca       1666
Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr           
                485                 490                 495               

tac tgt gac ccc gca tct ctg ttc cat gtt tct aat gat tac tca ttc       1714
Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe           
            500                 505                 510                   

att cga tat tac aca agg acc ctt tac caa ttc cag ttt caa gaa gca       1762
Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala           
        515                 520                 525                       

ctt tgt caa gca gct aaa cat gaa ggc cct ctg cac aaa tgt gac atc       1810
Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile           
    530                 535                 540                           

tca aac tct aca gaa gct gga cag aaa ctg ttg gag gag gat gtg cga       1858
Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Leu Glu Glu Asp Val Arg           
545                 550                 555                 560           

gtg gct aat ttg aaa cca aga atc tcc ttt aat ttc ttt gtc act gca       1906
Val Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala           
                565                 570                 575               

cct aaa aat gtg tct gat atc att cct aga act gaa gtt gaa aag gcc       1954
Pro Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala           
            580                 585                 590                   

atc agg atg tcc cgg agc cgt atc aat gat gct ttc cgt ctg aat gac       2002
Ile Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp           
        595                 600                 605                       

aac agc cta gag ttt ctg ggg ata cag cca aca ctt gga cct cct aac       2050
Asn Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn           
    610                 615                 620                           

cag ccc cct gtt tcc ata tgg ctg att gtt ttt gga gtt gtg atg gga       2098
Gln Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly           
625                 630                 635                 640           

gtg ata gtg gtt ggc att gtc atc ctg atc ttc act ggg atc aga gat       2146
Val Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp           
                645                 650                 655               

cgg aag aag aaa aat aaa gca aga agt gga gaa aat cct tat gcc tcc       2194
Arg Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser           
            660                 665                 670                   

atc gat att agc aaa gga gaa aat aat cca gga ttc caa aac act gat       2242
Ile Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp           
        675                 680                 685                       

gat gtt cag acc tcc ttt tag aaaaatctat gtttttcctc ttgaggtgat          2293
Asp Val Gln Thr Ser Phe                                                   
    690                                                                   

tttgttgtat gtaaatgtta atttcatggt atagaaaata taagatgata aagatatcat     2353

taaatgtcaa aactatgact ctgttcagaa aaaaaattgt ccaaagacaa catggccaag     2413

gagagagcat cttcattgac attgctttca gtatttattt ctgtctctgg atttgacttc     2473

tgttctgttt cttaataagg attttgtatt agagtatatt agggaaagtg tgtatttggt     2533

ctcacaggct gttcagggat aatctaaatg taaatgtctg ttgaatttct gaagttgaaa     2593

acaaggatat atcattggag caagtgttgg atcttgtatg gaatatggat ggatcacttg     2653

taaggacagt gcctgggaac tggtgtagct gcaaggattg agaatggcat gcattagctc     2713

actttcattt aatccattgt caaggatgac atgctttctt cacagtaact cagttcaagt     2773

actatggtga tttgcctaca gtgatgtttg gaatcgatca tgctttcttc aaggtgacag     2833

gtctaaagag agaagaatcc agggaacagg tagaggacat tgctttttca cttccaaggt     2893

gcttgatcaa catctccctg acaacacaaa actagagcca ggggcctccg tgaactccca     2953

gagcatgcct gatagaaact catttctact gttctctaac tgtggagtga atggaaattc     3013

caactgtatg ttcaccctct gaagtgggta cccagtctct taaatctttt gtatttgctc     3073

acagtgtttg agcagtgctg agcacaaagc agacactcaa taaatgctag atttacacac     3133

tc                                                                    3135


<210>  16
<211>  694
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Leu Glu Glu Asp Val Arg 
545                 550                 555                 560 


Val Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala 
                565                 570                 575     


Pro Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala 
            580                 585                 590         


Ile Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp 
        595                 600                 605             


Asn Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn 
    610                 615                 620                 


Gln Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly 
625                 630                 635                 640 


Val Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp 
                645                 650                 655     


Arg Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser 
            660                 665                 670         


Ile Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp 
        675                 680                 685             


Asp Val Gln Thr Ser Phe 
    690                 


