                         SEQUENCE LISTING

<110>  Ϻ＼޹˾
 
<120>  CD22ԽϿ弰Ʊ˫CARTϵ;

<130>  IEC220117PCT

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  123
<212>  PRT
<213>  artificial

<220>
<223>  15E11 VH

<400>  1

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Gln Asn Asp Gly Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Phe 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Gly Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asn Phe Lys Tyr Asp Glu Gly Ala Trp Phe Pro Tyr 
            100                 105                 110         


Trp Gly Gln Gly Ile Leu Val Thr Val Ser Ala 
        115                 120             


<210>  2
<211>  111
<212>  PRT
<213>  artificial

<220>
<223>  15E11 VL

<400>  2

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ile Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Arg Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Ala Tyr Ser Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Arg Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile Gln 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Gly Ile Pro Tyr Thr Phe Gly Gly Gly Thr Asn Leu Glu Met Lys 
            100                 105                 110     


<210>  3
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  15E11 VHCDR1

<400>  3

Gly Tyr Val Met His 
1               5   


<210>  4
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  15E11 VHCDR2

<400>  4

Tyr Ile Asn Pro Gln Asn Asp Gly Ile Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  15E11 VHCDR3

<400>  5

Gly Gly Asn Phe Lys Tyr Asp Glu Gly Ala Trp Phe Pro Tyr 
1               5                   10                  


<210>  6
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  15E11 VLCDR1

<400>  6

Arg Ala Arg Gln Ser Val Ser Thr Ser Ala Tyr Ser Phe Ile His 
1               5                   10                  15  


<210>  7
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  15E11 VLCDR2

<400>  7

Tyr Ala Ser Asn Leu Glu Ser 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  15E11 VLCDR3

<400>  8

Gln His Ser Trp Gly Ile Pro Tyr Thr 
1               5                   


<210>  9
<211>  735
<212>  PRT
<213>  artificial

<220>
<223>  scFv-BBz-1

<400>  9

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Lys Thr Phe Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
    130                 135                 140                 


Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
145                 150                 155                 160 


Thr Phe Thr Gly Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln 
                165                 170                 175     


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Gln Asn Asp Gly Ile Lys 
            180                 185                 190         


Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser 
        195                 200                 205             


Ser Ser Thr Ala Phe Met Glu Leu Ser Ser Leu Thr Ser Gly Asp Ser 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Arg Gly Gly Asn Phe Lys Tyr Asp Glu Gly 
225                 230                 235                 240 


Ala Trp Phe Pro Tyr Trp Gly Gln Gly Ile Leu Val Thr Val Ser Ala 
                245                 250                 255     


Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
            260                 265                 270         


Lys Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ile Val Ser 
        275                 280                 285             


Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Arg Gln Ser Val Ser 
    290                 295                 300                 


Thr Ser Ala Tyr Ser Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Gln 
305                 310                 315                 320 


Pro Pro Arg Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val 
                325                 330                 335     


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn 
            340                 345                 350         


Ile Gln Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His 
        355                 360                 365             


Ser Trp Gly Ile Pro Tyr Thr Phe Gly Gly Gly Thr Asn Leu Glu Met 
    370                 375                 380                 


Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
385                 390                 395                 400 


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
                405                 410                 415     


Phe Ser Leu Glu Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly 
            420                 425                 430         


Lys Gly Leu Glu Trp Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
        435                 440                 445             


Tyr Asn Ser Ser Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser 
    450                 455                 460                 


Lys Asn Gln Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
465                 470                 475                 480 


Ala Val Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
                485                 490                 495     


Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly 
            500                 505                 510         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        515                 520                 525             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    530                 535                 540                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
545                 550                 555                 560 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                565                 570                 575     


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            580                 585                 590         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        595                 600                 605             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
    610                 615                 620                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
625                 630                 635                 640 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                645                 650                 655     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            660                 665                 670         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        675                 680                 685             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    690                 695                 700                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
705                 710                 715                 720 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                725                 730                 735 


<210>  10
<211>  123
<212>  PRT
<213>  artificial

<220>
<223>  15E11-2 VH

<400>  10

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Gln Asn Asp Gly Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ser Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asn Phe Lys Tyr Asp Glu Gly Ala Trp Phe Pro Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  11
<211>  111
<212>  PRT
<213>  artificial

<220>
<223>  15E11-2 VL

<400>  11

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Arg Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Ala Tyr Ser Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Gly Ile Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  12
<211>  330
<212>  PRT
<213>  artificial

<220>
<223>  㶨

<400>  12

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  13
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  㶨

<400>  13

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  14
<211>  120
<212>  PRT
<213>  artificial

<220>
<223>  7E11 VH

<400>  14

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Glu Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  15
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  7E11 VL

<400>  15

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Gly Lys Thr Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  16
<211>  369
<212>  DNA
<213>  artificial

<220>
<223>  15E11 VHĺ

<400>  16
gaggtccagc tgcagcagtc tggacctgag ctggtaaagc ctggggcctc agtgaagatg       60

tcctgcaagg cttctggata cacgttcact ggctatgtta tgcactgggt gaagcagaag      120

cctgggcagg gccttgagtg gattggatat attaatcctc aaaatgatgg tattaagtac      180

aatgagaaat tcaaaggcaa ggccacactg acttcagaca aatcgtccag cacagccttc      240

atggagctca gcagcctgac ctctggggac tctgcggtct attactgtgc aagaggtggg      300

aactttaaat acgacgaggg cgcctggttt ccttactggg gccaagggat tctggtcact      360

gtctctgca                                                              369


<210>  17
<211>  333
<212>  DNA
<213>  artificial

<220>
<223>  15E11 VLĺ

<400>  17
gacattgttc tgacacagtc tcctgcctcc ttaattgtat ctctgggtca gagggccacc       60

atctcatgca gggcccgcca aagtgtcagt acatctgcct atagttttat tcactggtac      120

caacagaaac caggacagcc acccagactc ctcatcaagt atgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag atttcaccct caacatccaa      240

cctgtggagg aggaggatac tgcaacatat tactgtcagc acagttgggg gattccgtac      300

acgttcggag gggggaccaa cctggaaatg aaa                                   333


<210>  18
<211>  369
<212>  DNA
<213>  artificial

<220>
<223>  15E11-2 VHĺ

<400>  18
caggtgcagc tggtgcagag cggcgccgag gtgaaaaagc ccggcgcctc agtgaaagtg       60

agctgcaagg ccagcggcta caccttcaca ggctacgtga tgcactgggt gcggcaggcc      120

cctggccagg gactggaatg gatgggatac atcaaccccc agaatgacgg gatcaagtac      180

aacgagaagt tcaaaggccg cgtgacaatg acctctgaca aaagcaccag cacagcctac      240

atggagctgt ccagcctgcg cagcgaggac acagccgtgt actactgcgc cagaggcggc      300

aacttcaagt acgacgaggg ggcctggttc ccctactggg gccagggaac cctggtgacc      360

gtgtccagc                                                              369


<210>  19
<211>  333
<212>  DNA
<213>  artificial

<220>
<223>  15E11-2 VLĺ

<400>  19
gacattcagc tgacccagag ccccagcagc ctgtccgcca gcgtgggaga cagagtgacc       60

atcacctgca gagccagaca gagcgtgagc acctccgcct actccttcat ccactggtat      120

cagcagaaac ccggcaaggc ccccaaactg ctgattaaat atgccagcaa cctggaaagc      180

ggcgtgccca gtagattctc cggcagcggc tccggaaccg acttcaccct gaccatcagc      240

agcctgcagc ccgaggatac cgccacctac tactgccagc acagctgggg catcccatac      300

accttcggac agggcaccaa gctggagatc aaa                                   333


<210>  20
<211>  45
<212>  PRT
<213>  artificial

<220>
<223>  

<400>  20

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  21
<211>  24
<212>  PRT
<213>  artificial

<220>
<223>  Ĥ

<400>  21

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  22
<211>  41
<212>  PRT
<213>  artificial

<220>
<223>  ̼ṹ

<400>  22

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu 
        35                  40      


<210>  23
<211>  113
<212>  PRT
<213>  artificial

<220>
<223>  CD3

<400>  23

Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
1               5                   10                  15      


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            20                  25                  30          


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        35                  40                  45              


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  24
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  ͷ1

<400>  24

Gly Gly Gly Gly Ser 
1               5   


<210>  25
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  ͷ2

<400>  25

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  26
<211>  735
<212>  PRT
<213>  artificial

<220>
<223>  scFv-BBz-2

<400>  26

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Lys Thr Phe Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
    130                 135                 140                 


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
145                 150                 155                 160 


Thr Phe Thr Gly Tyr Val Met His Trp Val Arg Gln Ala Pro Gly Gln 
                165                 170                 175     


Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Gln Asn Asp Gly Ile Lys 
            180                 185                 190         


Tyr Asn Glu Lys Phe Lys Gly Arg Val Thr Met Thr Ser Asp Lys Ser 
        195                 200                 205             


Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Arg Gly Gly Asn Phe Lys Tyr Asp Glu Gly 
225                 230                 235                 240 


Ala Trp Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255     


Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
            260                 265                 270         


Lys Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
        275                 280                 285             


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Arg Gln Ser Val Ser 
    290                 295                 300                 


Thr Ser Ala Tyr Ser Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Lys 
305                 310                 315                 320 


Ala Pro Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val 
                325                 330                 335     


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
            340                 345                 350         


Ile Ser Ser Leu Gln Pro Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His 
        355                 360                 365             


Ser Trp Gly Ile Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
    370                 375                 380                 


Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
385                 390                 395                 400 


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
                405                 410                 415     


Phe Ser Leu Glu Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly 
            420                 425                 430         


Lys Gly Leu Glu Trp Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
        435                 440                 445             


Tyr Asn Ser Ser Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser 
    450                 455                 460                 


Lys Asn Gln Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
465                 470                 475                 480 


Ala Val Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
                485                 490                 495     


Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly 
            500                 505                 510         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        515                 520                 525             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    530                 535                 540                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
545                 550                 555                 560 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                565                 570                 575     


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            580                 585                 590         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        595                 600                 605             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
    610                 615                 620                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
625                 630                 635                 640 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                645                 650                 655     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            660                 665                 670         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        675                 680                 685             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    690                 695                 700                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
705                 710                 715                 720 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                725                 730                 735 


<210>  27
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  ź

<400>  27

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


