                         SEQUENCE LISTING

<110>  Ϻ＼޹˾
 
<120>  CD22ԽϿ弰Ʊ;

<130>  IEC220116PCT

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  123
<212>  PRT
<213>  artificial

<220>
<223>  13G9 VH

<400>  1

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Val Gly Ile Ser Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Arg Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Asn Val Asp Thr Thr Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Thr Asn Gly Gly Phe Phe Leu Tyr Ala Leu Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  2
<211>  111
<212>  PRT
<213>  artificial

<220>
<223>  13G9 VL

<400>  2

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Leu Asp Asn Tyr 
            20                  25                  30          


Gly Leu Thr Phe Leu Thr Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Phe Thr Thr Ser Arg Arg Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Leu Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Thr Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  3
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  13G9 VHCDR1

<400>  3

Thr Ser Gly Val Gly Ile Ser 
1               5           


<210>  4
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  13G9 VHCDR2

<400>  4

His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  5
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  13G9 VHCDR3

<400>  5

Arg Thr Asn Gly Gly Phe Phe Leu Tyr Ala Leu Asp Tyr 
1               5                   10              


<210>  6
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  13G9 VLCDR1

<400>  6

Arg Ala Ser Glu Ser Leu Asp Asn Tyr Gly Leu Thr Phe Leu Thr 
1               5                   10                  15  


<210>  7
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  13G9 VLCDR2

<400>  7

Thr Thr Ser Arg Arg Gly Ser 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  13G9 VLCDR3

<400>  8

Gln Gln Thr Lys Glu Val Pro Trp Thr 
1               5                   


<210>  9
<211>  330
<212>  PRT
<213>  artificial

<220>
<223>  㶨

<400>  9

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  10
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  㶨

<400>  10

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  11
<211>  123
<212>  PRT
<213>  artificial

<220>
<223>  hu13G9 VH

<400>  11

Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Val Gly Ile Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Thr Ser Gly Gly Phe Phe Leu Tyr Ala Leu Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  12
<211>  111
<212>  PRT
<213>  artificial

<220>
<223>  hu13G9 VL

<400>  12

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Leu Asp Asn Tyr 
            20                  25                  30          


Gly Leu Thr Phe Leu Thr Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Phe Thr Thr Ser Arg Arg Gly Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Thr Ala Thr Tyr Phe Cys Gln Gln Thr Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  13
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  hu13G9 VHCDR3

<400>  13

Arg Thr Ser Gly Gly Phe Phe Leu Tyr Ala Leu Asp Tyr 
1               5                   10              


<210>  14
<211>  369
<212>  DNA
<213>  artificial

<220>
<223>  13G9 VHĺ

<400>  14
caggtcactc tgaaagaatc cggaccaggc attctgcaac catctcagac attgtcattg       60

acctgcagtt tcagcggctt cagcctgtcc acaagcggag taggcatcag ttggatcaga      120

cagccatccg ggaagggcct ggagtggttg gctcatattt actgggatga tgacaaacga      180

tacaacccct cactgaaaag tagattgacc atctctaagg acacctcccg caatcaggtg      240

ttcttgaaga taaccaacgt ggatactacc gatacagcca cctactattg tgctaggcgg      300

actaacgggg gcttcttcct gtacgctctg gattactggg gtcaaggcac ctccgtcact      360

gtgtcctcc                                                              369


<210>  15
<211>  333
<212>  DNA
<213>  artificial

<220>
<223>  13G9 VLĺ

<400>  15
gatatagtgc tcacacagtc ccccgcatct ctcgcagttt cactgggcca gagagcaact       60

atatcatgtc gcgccagcga atcactggac aattacgggc tgaccttctt gacctggttc      120

cagcagaagc caggccagcc accgaagctg ctgattttca caacaagtag aagaggctcc      180

ggagttcctg cacggttttc aggtagtggg tccggtaccg atttttccct gaatatccac      240

cccttggagg aggacgatac tgccatgtat ttctgtcagc agacaaagga agtcccctgg      300

actttcgggg gcggaacgaa gctggaaatc aag                                   333


<210>  16
<211>  369
<212>  DNA
<213>  artificial

<220>
<223>  hu13G9 VHĺ

<400>  16
caggtgaccc tgaaggagag cggccccacc ctggtgaaac ccacacagac cctgaccctg       60

acctgcacat tctccggctt cagcctgagc acaagcggcg tgggcatcag ctggatcaga      120

cagccccccg gcaaggccct ggaatggctg gctcacatct actgggacga cgacaaaaga      180

tacaacccct ccctgaagag cagactgaca atcaccaagg acacctcaaa gaaccaggtg      240

gtgctgacaa tgacaaacat ggaccccgtg gacaccgcca cctactactg cgccagacgc      300

acctccggcg gcttcttcct gtacgccctg gactactggg gccagggcac cctggtgacc      360

gtgagcagc                                                              369


<210>  17
<211>  333
<212>  DNA
<213>  artificial

<220>
<223>  hu13G9 VLĺ

<400>  17
gacattcagc tgacccagag ccccagcagc ctgtccgcca gcgtgggaga cagagtgacc       60

atcacctgca gagccagcga gagcctggac aactacggac tgacctttct gacctggttt      120

cagcagaagc ccggcaaggc ccccaaactg ctgattttca ccaccagcag aagaggcagc      180

ggcgtgccca gcagattttc cggcagcggc agcggaaccg acttcaccct gactatcagc      240

agcctgcagc ccgaggatac cgctacctac ttctgtcagc agaccaagga ggtgccctgg      300

accttcggcg gcgggacaaa ggtggagatc aaa                                   333


