﻿                         序列表

<110>  凯莱英医药集团（天津）股份有限公司

<120>  固定化酶、其制备方法及应用

<130>  PN171681KLY

<160>  8

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  338
<212>  PRT
<213>  Sciscionella sp. SE31

<400>  1
Met Thr Thr Thr Glu Phe Ala Asn Ser Asn Leu Val Ala Val Glu Pro 
1               5                   10                  15      
Gly Ala Ile Arg Glu Pro Thr Pro Pro Gly Ser Val Ile Gln Tyr Ser 
            20                  25                  30          
Glu Tyr Glu Leu Asp Arg Ser Gln Pro Leu Ala Gly Gly Val Ala Trp 
        35                  40                  45              
Ile Glu Gly Glu Tyr Val Pro Ala Asp Glu Ala Arg Ile Ser Ile Phe 
    50                  55                  60                  
Asp Thr Gly Phe Gly His Ser Asp Leu Thr Tyr Thr Val Ala His Val 
65                  70                  75                  80  
Trp His Gly Asn Ile Phe Arg Leu Glu Asp His Leu Asp Arg Leu Leu 
                85                  90                  95      
His Gly Ala Ala Arg Leu Lys Leu Glu Thr Gly Met Ser Arg Glu Glu 
            100                 105                 110         
Leu Ala Gly Ile Ala Lys Arg Cys Val Ser Leu Ser Gln Leu Arg Glu 
        115                 120                 125             
Ala Tyr Val Asn Ile Thr Ile Thr Arg Gly Tyr Gly Lys Lys Arg Gly 
    130                 135                 140                 
Glu Lys Asp Leu Thr Lys Leu Thr His Gln Val Tyr Val Tyr Ala Ile 
145                 150                 155                 160 
Pro Tyr Leu Trp Ala Phe Pro Pro Glu Glu Gln Ile Phe Gly Thr Ser 
                165                 170                 175     
Val Ile Val Pro Arg His Val Arg Arg Ala Gly Arg Asn Thr Ile Asp 
            180                 185                 190         
Pro Thr Ile Lys Asn Tyr Gln Trp Gly Asp Leu Thr Ala Ala Ser Phe 
        195                 200                 205             
Glu Ala Lys Asp Arg Gly Ala Arg Ser Ala Val Leu Leu Asp Ala Asp 
    210                 215                 220                 
Asn Cys Val Ala Glu Gly Pro Gly Phe Asn Val Val Leu Val Lys Asp 
225                 230                 235                 240 
Gly Ala Leu Val Ser Pro Ser Arg Asn Ala Leu Pro Gly Ile Thr Arg 
                245                 250                 255     
Lys Thr Val Tyr Glu Ile Ala Ala Ala Lys Gly Ile Glu Thr Met Leu 
            260                 265                 270         
Arg Asp Val Thr Ser Ser Glu Leu Tyr Glu Ala Asp Glu Leu Met Ala 
        275                 280                 285             
Val Thr Thr Ala Gly Gly Val Thr Pro Ile Thr Ser Leu Asp Gly Glu 
    290                 295                 300                 
Gln Val Gly Asn Gly Glu Pro Gly Pro Ile Thr Val Ala Ile Arg Asp 
305                 310                 315                 320 
Arg Phe Trp Ala Leu Met Asp Glu Pro Ser Ser Leu Ile Glu Ala Ile 
                325                 330                 335     
Asp Tyr 
        

<210>  2
<211>  253
<212>  PRT
<213>  Acetobacter sp. CCTCC M209061

<400>  2
Met Thr Arg Val Ala Gly Lys Val Ala Ile Val Ser Gly Ala Ala Asn 
1               5                   10                  15      
Gly Ile Gly Lys Ala Thr Ala Gln Leu Leu Ala Lys Glu Gly Ala Lys 
            20                  25                  30          
Val Val Ile Gly Asp Leu Lys Glu Glu Asp Gly Gln Lys Ala Val Ala 
        35                  40                  45              
Glu Ile Lys Ala Ala Gly Gly Glu Ala Ala Phe Val Lys Leu Asn Val 
    50                  55                  60                  
Thr Asp Glu Ala Ala Trp Lys Ala Ala Ile Glu Gln Thr Leu Lys Leu 
65                  70                  75                  80  
Tyr Gly Arg Leu Asp Ile Ala Val Asn Asn Ala Gly Ile Ala Tyr Ser 
                85                  90                  95      
Gly Ser Val Glu Ser Thr Ser Leu Glu Asp Trp Arg Arg Val Gln Ser 
            100                 105                 110         
Ile Asn Leu Asp Gly Val Phe Leu Gly Thr Gln Val Ala Ile Glu Ala 
        115                 120                 125             
Met Lys Lys Ser Gly Gly Gly Ser Ile Val Asn Leu Ser Ser Ile Glu 
    130                 135                 140                 
Gly Leu Ile Gly Asp Pro Met Gly Ala Ala Tyr Asn Ala Ser Lys Gly 
145                 150                 155                 160 
Gly Val Arg Leu Phe Thr Lys Ser Ala Ala Leu His Cys Ala Lys Ser 
                165                 170                 175     
Gly Tyr Lys Ile Arg Val Asn Ser Val His Pro Gly Tyr Ile Trp Thr 
            180                 185                 190         
Pro Met Val Ala Gly Leu Thr Lys Glu Asp Ala Ala Ala Arg Gln Lys 
        195                 200                 205             
Leu Val Asp Leu His Pro Ile Gly His Leu Gly Glu Pro Asn Asp Ile 
    210                 215                 220                 
Ala Tyr Gly Ile Leu Tyr Leu Ala Ser Asp Glu Ser Lys Phe Val Thr 
225                 230                 235                 240 
Gly Ser Glu Leu Val Ile Asp Gly Gly Tyr Thr Ala Gln 
                245                 250             

<210>  3
<211>  603
<212>  PRT
<213>  Rhodococcus ruber-SD1

<400>  3
Met Thr Thr Ser Ile Asp Arg Glu Ala Leu Arg Arg Lys Tyr Ala Glu 
1               5                   10                  15      
Glu Arg Asp Lys Arg Ile Arg Pro Asp Gly Asn Asp Gln Tyr Ile Arg 
            20                  25                  30          
Leu Asp His Val Asp Gly Trp Ser His Asp Pro Tyr Met Pro Ile Thr 
        35                  40                  45              
Pro Arg Glu Pro Lys Leu Asp His Val Thr Phe Ala Phe Ile Gly Gly 
    50                  55                  60                  
Gly Phe Ser Gly Leu Val Thr Ala Ala Arg Leu Arg Glu Ser Gly Val 
65                  70                  75                  80  
Glu Ser Val Arg Ile Ile Asp Lys Ala Gly Asp Phe Gly Gly Val Trp 
                85                  90                  95      
Tyr Trp Asn Arg Tyr Pro Gly Ala Met Cys Asp Thr Ala Ala Met Val 
            100                 105                 110         
Tyr Met Pro Leu Leu Glu Glu Thr Gly Tyr Met Pro Thr Glu Lys Tyr 
        115                 120                 125             
Ala His Gly Pro Glu Ile Leu Glu His Cys Gln Arg Ile Gly Lys His 
    130                 135                 140                 
Tyr Asp Leu Tyr Asp Asp Ala Leu Phe His Thr Glu Val Thr Asp Leu 
145                 150                 155                 160 
Val Trp Gln Glu His Asp Gln Arg Trp Arg Ile Ser Thr Asn Arg Gly 
                165                 170                 175     
Asp His Phe Thr Ala Gln Phe Val Gly Met Gly Thr Gly Pro Leu His 
            180                 185                 190         
Val Ala Gln Leu Pro Gly Ile Pro Gly Ile Glu Ser Phe Arg Gly Lys 
        195                 200                 205             
Ser Phe His Thr Ser Arg Trp Asp Tyr Asp Tyr Thr Gly Gly Asp Ala 
    210                 215                 220                 
Leu Gly Ala Pro Met Asp Lys Leu Ala Asp Lys Arg Val Ala Val Ile 
225                 230                 235                 240 
Gly Thr Gly Ala Thr Ala Val Gln Cys Val Pro Glu Leu Ala Lys Tyr 
                245                 250                 255     
Cys Arg Glu Leu Tyr Val Val Gln Arg Thr Pro Ser Ala Val Asp Glu 
            260                 265                 270         
Arg Gly Asn His Pro Ile Asp Glu Lys Trp Phe Ala Gln Ile Ala Thr 
        275                 280                 285             
Pro Gly Trp Gln Lys Arg Trp Leu Asp Ser Phe Thr Ala Ile Trp Asp 
    290                 295                 300                 
Gly Val Leu Thr Asp Pro Ser Glu Leu Ala Ile Glu His Glu Asp Leu 
305                 310                 315                 320 
Val Gln Asp Gly Trp Thr Ala Leu Gly Gln Arg Met Arg Ala Ala Val 
                325                 330                 335     
Gly Ser Val Pro Ile Glu Gln Tyr Ser Pro Glu Asn Val Gln Arg Ala 
            340                 345                 350         
Leu Glu Glu Ala Asp Asp Glu Gln Met Glu Arg Ile Arg Ala Arg Val 
        355                 360                 365             
Asp Glu Ile Val Thr Asp Pro Ala Thr Ala Ala Gln Leu Lys Ala Trp 
    370                 375                 380                 
Phe Arg Gln Met Cys Lys Arg Pro Cys Phe His Asp Asp Tyr Leu Pro 
385                 390                 395                 400 
Ala Phe Asn Arg Pro Asn Thr His Leu Val Asp Thr Gly Gly Lys Gly 
                405                 410                 415     
Val Glu Arg Ile Thr Glu Asn Gly Val Val Val Ala Gly Val Glu Tyr 
            420                 425                 430         
Glu Val Asp Cys Ile Val Tyr Ala Ser Gly Phe Glu Phe Leu Gly Thr 
        435                 440                 445             
Gly Tyr Thr Asp Arg Ala Gly Phe Asp Pro Thr Gly Arg Asp Gly Val 
    450                 455                 460                 
Lys Leu Ser Glu His Trp Ala Gln Gly Thr Arg Thr Leu His Gly Met 
465                 470                 475                 480 
His Thr Tyr Gly Phe Pro Asn Leu Phe Val Leu Gln Leu Met Gln Gly 
                485                 490                 495     
Ala Ala Leu Gly Ser Asn Ile Pro His Asn Phe Val Glu Ala Ala Arg 
            500                 505                 510         
Val Val Ala Ala Ile Val Asp His Val Leu Ser Thr Gly Thr Ser Ser 
        515                 520                 525             
Val Glu Thr Thr Lys Glu Ala Glu Gln Ala Trp Val Gln Leu Leu Leu 
    530                 535                 540                 
Asp His Gly Arg Pro Leu Gly Asn Pro Glu Cys Thr Pro Gly Tyr Tyr 
545                 550                 555                 560 
Asn Asn Glu Gly Lys Pro Ala Glu Leu Lys Asp Arg Leu Asn Val Gly 
                565                 570                 575     
Tyr Pro Ala Gly Ser Ala Ala Phe Phe Arg Met Met Asp His Trp Leu 
            580                 585                 590         
Ala Ala Gly Ser Phe Asp Gly Leu Thr Phe Arg 
        595                 600             

<210>  4
<211>  353
<212>  PRT
<213>  Chryseobacterium sp. CA49

<400>  4
Met Ser Thr Glu Ser Leu Phe Thr Pro Phe Lys Tyr Lys Asn Leu Glu 
1               5                   10                  15      
Leu Lys Asn Arg Ile Val Met Ala Pro Met Thr Arg Ala Gln Ser Asp 
            20                  25                  30          
Asn Gly Val Pro Thr Gln Gln Ile Ala Asp Tyr Tyr Ala Arg Arg Ala 
        35                  40                  45              
Ala Ala Glu Val Gly Leu Ile Leu Ser Glu Gly Thr Val Ile Asn Arg 
    50                  55                  60                  
Pro Ala Ser Lys Asn Met Gln Asn Ile Pro Asp Phe Tyr Gly Thr Glu 
65                  70                  75                  80  
Ala Leu Asn Gly Trp Lys Asn Val Ile Asp Ala Val His His Asn Gly 
                85                  90                  95      
Gly Lys Met Gly Pro Gln Ile Trp His Val Gly Asp Thr Arg Ser Thr 
            100                 105                 110         
Pro Asp Tyr Pro Leu Glu Asp Met Glu Lys Ala Ser Thr Met Thr Leu 
        115                 120                 125             
Glu Asp Ile Gln Asp Thr Ile Ala Gln Phe Ala Ala Ser Ala Lys Ser 
    130                 135                 140                 
Ala Lys Asp Leu Gly Phe Asp Val Leu Glu Ile His Gly Ala His Gly 
145                 150                 155                 160 
Tyr Leu Ile Asp Gln Phe Phe Trp Glu Gly Thr Asn Thr Arg Thr Asp 
                165                 170                 175     
Glu Tyr Gly Gly Lys Thr Ile Lys Glu Arg Ser Arg Phe Ala Val Asp 
            180                 185                 190         
Val Val Lys Ala Ile Arg Ala Ala Val Gly Glu Asp Phe Thr Ile Ile 
        195                 200                 205             
Ile Arg Leu Ser Gln Trp Lys Gln Gln Asp Tyr Ser Val Lys Leu Ala 
    210                 215                 220                 
His Thr Pro Glu Glu Met Glu Glu Trp Leu Leu Pro Leu Lys Asp Ala 
225                 230                 235                 240 
Gly Val Asp Ile Phe His Cys Ser Gln Arg Arg Phe Trp Glu Pro Glu 
                245                 250                 255     
Phe Glu Gly Ser Asp Leu Asn Phe Ala Gly Trp Ala Lys Lys Ile Thr 
            260                 265                 270         
Gly Gln Pro Thr Ile Thr Val Gly Ser Val Gly Leu Glu Gly Asp Phe 
        275                 280                 285             
Met Ala Ala Phe Gly Gly Gln Gly Thr Glu Lys Ala Asp Leu Thr Glu 
    290                 295                 300                 
Leu Thr Lys Arg Leu Glu Arg Gly Asp Phe Asp Leu Val Ala Val Gly 
305                 310                 315                 320 
Arg Ala Leu Leu Gln Asp Pro Glu Trp Ala Lys Lys Val Lys Glu Gln 
                325                 330                 335     
Asn Thr Glu Ala Leu Leu Asp Phe Ser Ala Glu Ser Leu Gly Val Leu 
            340                 345                 350         
Tyr 
    

<210>  5
<211>  285
<212>  PRT
<213>  Amycolatopsis decaplanina

<400>  5
Met Ser Pro Gly Gly Thr Leu Thr Leu Gly Asp Leu Thr Val Ser Arg 
1               5                   10                  15      
Met Gly Tyr Gly Ala Met Arg Leu Ser Gly Pro Gly Ile Trp Gly Pro 
            20                  25                  30          
Pro Ser Asp Arg Glu Thr Ala Ile Ala Val Leu Arg Glu Ala Val Glu 
        35                  40                  45              
Leu Gly Val Thr His Ile Asp Thr Ser Asp Phe Tyr Gly Pro His Thr 
    50                  55                  60                  
Val Asn Glu Leu Ile Arg Glu Ala Leu His Pro Tyr Pro Asp Glu Leu 
65                  70                  75                  80  
His Ile Val Thr Lys Val Gly Ala Lys Arg Ser Pro Asp Lys Gly Trp 
                85                  90                  95      
Pro Ser Ala Leu Ser Arg Glu Glu Leu Thr Ser Ala Val His Asp Asn 
            100                 105                 110         
Leu Arg Asn Leu Gly Val Asp Val Leu Asp Val Val Asn Leu Arg Leu 
        115                 120                 125             
Ala Gly Glu His Gly Val Phe Pro Ile Pro Val Ser Ile Thr Glu Pro 
    130                 135                 140                 
Phe Glu Val Leu Ala Glu Leu Arg Gln Gln Gly Leu Ile Arg His Leu 
145                 150                 155                 160 
Gly Leu Ser His Val Ser Ala Glu Gln Val Lys Glu Ala Arg Ala Ile 
                165                 170                 175     
Ala Pro Val Val Cys Val Gln Asn Glu Tyr Asn Val Ala Asn Arg Ala 
            180                 185                 190         
Asn Asp Asp Leu Leu Asp Ala Leu Ala Ala Ile Asn Ile Pro Phe Val 
        195                 200                 205             
Pro Tyr Phe Pro Leu Gly Gly Phe Thr Pro Leu Gln Ser Gly Val Leu 
    210                 215                 220                 
Asp Asp Cys Ala Arg Arg Val Asp Ala Thr Pro Met Gln Val Ala Leu 
225                 230                 235                 240 
Ala Trp Leu Leu Gln Arg Ser Pro Asn Ile Leu Val Ile Pro Gly Thr 
                245                 250                 255     
Ser Ser Pro Ser His Leu Arg Glu Asn Val Ala Ala Ala Lys Leu Glu 
            260                 265                 270         
Leu Pro Ala Asp Val Ile Ala Asp Leu Asp Ala Leu Val 
        275                 280                 285 

<210>  6
<211>  299
<212>  PRT
<213>  Saccharothrix syringae

<400>  6
Met Thr Asp Asn Ala Leu Ala Gln Pro Gly Pro Ser Thr Pro Leu Thr 
1               5                   10                  15      
Leu Leu Gly Thr Gly Ala Met Gly Thr Ala Leu Ala Arg Ala Trp Leu 
            20                  25                  30          
Ala Ala Gly His Pro Val Thr Val Trp Asn Arg Thr Pro Ala Arg Ala 
        35                  40                  45              
Glu Ala Leu Ala Ala Glu Gly Ala Thr Val Ala Ala Ser Ala Ala Glu 
    50                  55                  60                  
Ala Val Ala Ala Asn Arg Leu Val Val Val Cys Leu Leu Asp Asp Ala 
65                  70                  75                  80  
Ser Val Gly Glu Ala Leu Asp Gly Ala Asp Leu Thr Gly Arg Asp Leu 
                85                  90                  95      
Val Asn Ile Thr Thr Gly Thr Pro Gly Gln Gly Arg Ser Arg Ala Ala 
            100                 105                 110         
Trp Ala Lys Ala Arg Gly Ala Arg Phe Leu Asp Gly Gly Ile Met Ala 
        115                 120                 125             
Val Pro Pro Met Ile Gly Ala Pro Asp Ser Gly Ala Tyr Val Phe Tyr 
    130                 135                 140                 
Ser Gly Ser Ala Ala Leu Phe Glu Glu His Arg Asp Thr Leu Ala Val 
145                 150                 155                 160 
Pro Ala Gly Thr Thr Tyr Val Gly Ala Asp Pro Gly Phe Ala Ala Leu 
                165                 170                 175     
His Asp Val Ala Leu Leu Ser Ala Met Asn Gly Met Phe Ala Gly Ile 
            180                 185                 190         
Thr His Ala Phe Ala Leu Ile Arg Arg Glu Asp Ile Ala Pro Lys Asp 
        195                 200                 205             
Phe Ala Pro Leu Leu Val Ser Trp Leu Thr Ala Met Ala His Ser Ala 
    210                 215                 220                 
His Lys Ala Ala Asp Gln Leu Glu Ser Gly Asp Tyr Gly Lys Asp Val 
225                 230                 235                 240 
Val Ser Ser Leu Ala Met Gln Val Ala Gly Asn Ala Thr Leu Leu Arg 
                245                 250                 255     
Thr Ala Glu Glu Gln Gly Val Ser Ala Glu Leu Leu Arg Pro Tyr Met 
            260                 265                 270         
Asp Leu Met Glu Arg Arg Leu Ala Leu Gly Asn Gly Glu Glu Asp Thr 
        275                 280                 285             
Thr Gly Val Val Glu Leu Leu Leu Arg Lys Pro 
    290                 295                 

<210>  7
<211>  366
<212>  PRT
<213>  Thermoactinomyces intermedius ATCC33205

<400>  7
Met Arg Asp Val Phe Glu Met Met Asp Arg Tyr Gly His Glu Gln Val 
1               5                   10                  15      
Ile Phe Cys Arg His Pro Gln Thr Gly Leu Lys Ala Ile Ile Ala Leu 
            20                  25                  30          
His Asn Thr Thr Ala Gly Pro Ala Leu Gly Gly Cys Arg Met Ile Pro 
        35                  40                  45              
Tyr Ala Ser Thr Asp Glu Ala Leu Glu Asp Val Leu Arg Leu Ser Lys 
    50                  55                  60                  
Gly Met Thr Tyr Lys Cys Ser Leu Ala Asp Val Asp Phe Gly Gly Gly 
65                  70                  75                  80  
Lys Met Val Ile Ile Gly Asp Pro Lys Lys Asp Lys Ser Pro Glu Leu 
                85                  90                  95      
Phe Arg Val Ile Gly Arg Phe Val Gly Gly Leu Asn Gly Arg Phe Tyr 
            100                 105                 110         
Thr Gly Thr Asp Met Gly Thr Asn Pro Glu Asp Phe Val His Ala Ala 
        115                 120                 125             
Arg Glu Ser Lys Ser Phe Ala Gly Leu Pro Lys Ser Tyr Gly Gly Lys 
    130                 135                 140                 
Gly Asp Thr Ser Ile Pro Thr Ala Leu Gly Val Phe His Gly Met Arg 
145                 150                 155                 160 
Ala Thr Ala Arg Phe Leu Trp Gly Thr Asp Gln Leu Lys Gly Arg Val 
                165                 170                 175     
Val Ala Ile Gln Gly Val Gly Lys Val Gly Glu Arg Leu Leu Gln Leu 
            180                 185                 190         
Leu Val Glu Val Gly Ala Tyr Cys Lys Ile Ala Asp Ile Asp Ser Val 
        195                 200                 205             
Arg Cys Glu Gln Leu Lys Glu Lys Tyr Gly Asp Lys Val Gln Leu Val 
    210                 215                 220                 
Asp Val Asn Arg Ile His Lys Glu Ser Cys Asp Ile Phe Ser Pro Cys 
225                 230                 235                 240 
Ala Lys Gly Gly Val Val Asn Asp Asp Thr Ile Asp Glu Phe Arg Cys 
                245                 250                 255     
Leu Ala Ile Val Gly Ser Ala Asn Asn Gln Leu Val Glu Asp Arg His 
            260                 265                 270         
Gly Ala Leu Leu Gln Lys Arg Ser Ile Cys Tyr Ala Pro Asp Tyr Leu 
        275                 280                 285             
Val Asn Ala Gly Gly Leu Ile Gln Val Ala Asp Glu Leu Glu Gly Phe 
    290                 295                 300                 
His Glu Glu Arg Val Leu Ala Lys Thr Glu Ala Ile Tyr Asp Met Val 
305                 310                 315                 320 
Leu Asp Ile Phe His Arg Ala Lys Asn Glu Asn Ile Thr Thr Cys Glu 
                325                 330                 335     
Ala Ala Asp Arg Ile Val Met Glu Arg Leu Lys Lys Leu Thr Asp Ile 
            340                 345                 350         
Arg Arg Ile Leu Leu Glu Asp Pro Arg Asn Ser Ala Arg Arg 
        355                 360                 365     

<210>  8
<211>  318
<212>  PRT
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  8
Met Leu Pro Ser Gly Ser Asp Pro Ala Phe Ser Gln Pro Lys Ser Val 
1               5                   10                  15      
Leu Asp Ala Gly Leu Thr Cys Gln Gly Ala Ser Pro Ser Ser Val Ser 
            20                  25                  30          
Lys Pro Ile Leu Leu Val Pro Gly Thr Gly Thr Thr Gly Pro Gln Ser 
        35                  40                  45              
Phe Asp Ser Asn Trp Ile Pro Leu Ser Thr Gln Leu Gly Tyr Thr Pro 
    50                  55                  60                  
Cys Trp Ile Ser Pro Pro Pro Phe Met Leu Asn Asp Thr Gln Val Asn 
65                  70                  75                  80  
Thr Glu Tyr Met Val Asn Ala Ile Thr Ala Leu Tyr Ala Gly Ser Gly 
                85                  90                  95      
Asn Asn Lys Leu Pro Val Leu Thr Trp Ser Gln Gly Gly Leu Val Ala 
            100                 105                 110         
Gln Trp Gly Leu Thr Phe Phe Pro Ser Ile Arg Ser Lys Val Asp Arg 
        115                 120                 125             
Leu Met Ala Phe Ala Pro Asp Tyr Lys Gly Thr Val Leu Ala Gly Pro 
    130                 135                 140                 
Leu Asp Ala Leu Ala Val Ser Ala Pro Ser Val Trp Gln Gln Thr Thr 
145                 150                 155                 160 
Gly Ser Ala Leu Thr Thr Ala Leu Arg Asn Ala Gly Gly Leu Thr Gln 
                165                 170                 175     
Ile Val Pro Thr Thr Asn Leu Tyr Ser Ala Thr Asp Glu Ile Val Gln 
            180                 185                 190         
Pro Gln Val Ser Asn Ser Pro Leu Asp Ser Ser Tyr Leu Phe Asn Gly 
        195                 200                 205             
Lys Asn Val Gln Ala Gln Ala Val Cys Gly Pro Leu Phe Val Ile Asp 
    210                 215                 220                 
His Ala Gly Ser Leu Thr Ser Gln Phe Ser Tyr Val Val Gly Arg Ser 
225                 230                 235                 240 
Ala Leu Arg Ser Thr Thr Gly Gln Ala Arg Ser Ala Asp Tyr Gly Ile 
                245                 250                 255     
Thr Asp Cys Asn Pro Leu Pro Ala Asn Asp Leu Thr Pro Glu Gln Lys 
            260                 265                 270         
Val Ala Ala Ala Ala Leu Leu Ala Pro Ala Ala Ala Ala Ile Val Ala 
        275                 280                 285             
Gly Pro Lys Gln Asn Cys Glu Pro Asp Leu Met Pro Tyr Ala Arg Pro 
    290                 295                 300                 
Phe Ala Val Gly Lys Arg Thr Cys Ser Gly Ile Val Thr Pro 
305                 310                 315             

