                         б

<110>  Ϻ孴Ƽ޹˾
 
<120>  ΪԳմϱ־DDIT4L в

<130>  0245-PA-004

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  4599
<212>  DNA
<213>  ˣHomo sapiens

<400>  1
gctactgcga ggagccggcg cagggtggcc cgggaggggt gagcagggtg ccgctggctg       60

ctggggtctg caggtcaccg agtccccagg agaggggact cctaagaagc cacctgcctg      120

tgtttacccg gcagcgagcg cgcaggcccc cgcgaactcc tggcaggtga gcgaagctgc      180

ggccttggtg ggggcagcgg ggccgggggg cgctccgcgg ggcaggtcgc ttccaagttt      240

tgcgaactgt tgagttagtt tcaggttgcg gctccgctcc cagggctttg tcaaattgag      300

ttgcagaggc cggttccacc cctttggcaa aggagttcct ccgctagttc gctcccggga      360

cgccgggcat tttaggagcc tctgcacgac tcgcctgctt ttgcaaatcc gtctcttctc      420

gcctcatttt ttccagcgct caggaaaggc cgttgcgcct cgcgaaggaa acagagccgt      480

tgaccatggt tgcaactggc agtttgagca gcaagaaccc ggccagcatt tcagaattgc      540

tggactgtgg ctatcaccca gagagcctgc taagtggtga gtgtccccgc tgtccaccct      600

tctcccctcc caaggtcggt gcctctggat ctattgggtg ggcgggcttt cgacttcctc      660

ccctacctct atgtaggagg tgccacaaaa tccatctgag gagactcctt tccaaatttt      720

ctaacatctt ctctccatga tagaaacaaa agtagcaaaa gtagaatacc cgagggctgc      780

atctttctag tctggtgcca gtaggcccct tgggattaag ttccttatct tacatgattg      840

tgaagaacac agttatgtgt gttttagcaa atgtatttac cctgtaatca atatcgcccc      900

tccccctgaa ttccgacgca cctatttgcc aggtattcct cactctcccc tgactccagg      960

gaactactga tctgattttt atcattccaa gttagttttg cctttaggta agtggaacca     1020

tacagtaggt attcttttgt gtctggtttc tttcccgcag cctaatgttt ttgagattct     1080

tttatgtccg ttgcttaaat cagtgtgttc gtgtttattg tttattactg agtaggattt     1140

tcagtcgtgg atatatccat tattccattt ttaatgtgag aaggaaactg ttgaacagca     1200

gcggtgcttg acttgctgtc atttggaatt ttaacagcag tttctaggtg aacacactgc     1260

tctgacacta aagagctgta agagcataga taaactgctt aagctcttcg tgtttttctc     1320

ctttcaaggt gaagtggttg atgacctaat ttacaggcca gaactccaaa cttacacgaa     1380

gtggagagga aaagccagtg gctgatgaag gtggagtagg cttagagaga ggagctggga     1440

gggcatctgc ctgcaccttg ttcatttgac tccgtgtggt gtggcatcct gccaaggggt     1500

aggattaatt tgaggtgtag gtgaccaaat gcagagctat ctcttttcct ttgagcccag     1560

ctaattttat ttccctagga ctattttgtt ttgcttggct aagaaaaacc acccagccgg     1620

ttacaaatat cctcatgaac ctcaaaggtc ttctctgcac aatttttaat taaagaggct     1680

aaagctaaaa ttgggaccta caggccactc cagtaaagac ttaaagacac aaatttgata     1740

gatctttaat ataactctta aagctttaat acaactcttc aaacataata gtaaaaattc     1800

tttattttac aatacatgta ttcctacagt tagaaagtaa caacccctta gtccaaaaaa     1860

caaagttata actttttatt ccagaagtaa tgcatgtttt ctgtaaaaca aaattagaaa     1920

acccccataa gcaagtagga gaaaagaaaa gaaaatcacc aataatctgg gataatcaca     1980

agtagatttt tgatgcatag tcttcacggt tgtgtgtgtg ttttgtgtac acacataaat     2040

ttaaagaaaa gtggttacat cctatctact ctatttatct aaacctttat ttcatacatg     2100

aactttcatt catgagagct taaattattc gctatattac ctagctagtt aacagttaat     2160

tgaggtcagc tgactctgaa acaaatacaa gaaaaaggca gacatggtag atagaggtaa     2220

ccaatgttga tatcttggtg ttttttttct actcttaaat tttttcttct gtatctaaaa     2280

agaaaactcc atttcttaca gattttgact actgggatta tgttgttcct gaacccaacc     2340

tcaacgaggt aatatttgag gaatcaactt gccagaattt ggttaaaatg ctggagaact     2400

gtctgtccaa atcaaagcaa actaaacttg gttgctcaaa ggtccttgtc cctgagaaac     2460

tgacccagag aattgctcaa gatgtcctgc ggctttcctc aacggagccc tgcggcttgc     2520

gaggttgtgt tatgcacgtg aacttggaaa ttgaaaatgt atgtaaaaag ctggatagga     2580

ttgtgtgtga ttctagcgtc gtacctactt ttgagcttac acttgtgttt aagcaggaga     2640

actgctcatg gactagcttc agggactttt tctttagtag aggtcgcttc tcctctggtt     2700

tcaggagaac tctgatcctc agctcaggat ttcgacttgt taagaaaaaa ctttactcac     2760

tgattggaac aacagtgatt gaagggtcct aaaaagggaa aatatataaa gattatttca     2820

tgattgggta gtaaaactat tcagctagtc agctaaagtc atttgtagtt tgccccacct     2880

gccctaaata agaaacccca aatgtagtct cttttctttc tgtgtttcac attcatagca     2940

actgcagcta acaggctgat tttctggcct ttggagaagt gattcaaaat agtgtagatt     3000

ttctgcatag atcccatttt tgtacagaat tgaatgggat ggaataggta agcaaaagta     3060

gaagcccatt tgagttttac atttgattcc acaatttggt ttcaggtagg cttggtaata     3120

gactatataa accagatttg cctattttga ttttcatatg gctttttttt ctgtaagttt     3180

tcagaggatt ttttaaatca cagaatcata ctaaatgata tttagcctat caaaacttcc     3240

aaaagcccac accaccagtt cctgactcaa atttgaaggg tttttagaca ggagggtagg     3300

attaagtagg tgagtttaat taaagcttaa ccctaggtaa gagtaaatga gaaatattac     3360

ggcaataatg gaactgcttc actgtttctt ggtgacttcc tcactctaat gttttaaaga     3420

ggcaacaaaa gcttgtggtg ccatttcagt aaccacggtg ttgttttaga tgcctttata     3480

agctcagttt cccctgttct taagtgttga atactgtctt taaactagaa aaatgcaaaa     3540

tattgaactg atatttttgt gtgtagttga ttactcttcc attgagtgaa tgatgaatac     3600

ctgtgaggat aggaaattag ttctgagatc tagtccctct ctgattcact tagtaatcta     3660

tcctcttttc agtattacat gtgcttaatc tcagatgaac catttcacca tggcagtgtt     3720

atctcatctc tgggcttttc tgggaattga agtatctctc cttaacccca attgtcaagg     3780

gtagtagctg tatactacca ctttgaatta ttgaaacggg tcaatttacg aagtctgcat     3840

tggctatgga gatatggttt atagtacagc ctagagaatg aaactcaccg tccagataac     3900

catgcatgca cccagatttt ttccaccttg gatacctgtc actagggaat aataaaggcc     3960

tgattttttg tcttattcca actaagtaga tcattatctc tttccttttt tatgttaatg     4020

agagaattta gcctccactc aacaatgttc aattcagcaa ggctttcata tccttgctgt     4080

gggtcgtgga taaggagctt attcaggttt cctgccctag ctattagctc cacttcacat     4140

gctggagacc ggcgtaggga cagatgtatt catcctggtg ttactgaaaa acaggtgtga     4200

tcctgttact gatactataa gtgacctaaa atgtcactgt tcaaattagc cagtgttcta     4260

acaaactaaa ctcttcaaat gcttggaaag atactacaaa gccaatcttt atagaattgg     4320

gccaagataa atctatgttg ttttgcatgg ctattgttaa gctccaaagg ttcactgtgt     4380

ttctgccgct gtcctggagt tgtcaccact gactgggcaa ggcttcttgg gcatggatgt     4440

agaactgttg tccttttccc actaacagtt atctttgact ctcttgcctg ttatgcttac     4500

aaaatggtga tggcttatgg aaggctgtta aattaatatt cctgttaaag gaaattaaag     4560

tttgtctatt tttgacaata aaacattata tatttttaa                            4599


<210>  2
<211>  4163
<212>  DNA
<213>  ˣHomo sapiens

<400>  2
cgctcaggaa aggccgttgc gcctcgcgaa ggaaacagag ccgttgacca tggttgcaac       60

tggcagtttg agcagcaaga acccggccag catttcagaa ttgctggact gtggctatca      120

cccagagagc ctgctaagtg gtgagtgtcc ccgctgtcca cccttctccc ctcccaaggt      180

cggtgcctct ggatctattg ggtgggcggg ctttcgactt cctcccctac ctctatgtag      240

gaggtgccac aaaatccatc tgaggagact cctttccaaa ttttctaaca tcttctctcc      300

atgatagaaa caaaagtagc aaaagtagaa tacccgaggg ctgcatcttt ctagtctggt      360

gccagtaggc cccttgggat taagttcctt atcttacatg attgtgaaga acacagttat      420

gtgtgtttta gcaaatgtat ttaccctgta atcaatatcg cccctccccc tgaattccga      480

cgcacctatt tgccaggtat tcctcactct cccctgactc cagggaacta ctgatctgat      540

ttttatcatt ccaagttagt tttgccttta ggtaagtgga accatacagt aggtattctt      600

ttgtgtctgg tttctttccc gcagcctaat gtttttgaga ttcttttatg tccgttgctt      660

aaatcagtgt gttcgtgttt attgtttatt actgagtagg attttcagtc gtggatatat      720

ccattattcc atttttaatg tgagaaggaa actgttgaac agcagcggtg cttgacttgc      780

tgtcatttgg aattttaaca gcagtttcta ggtgaacaca ctgctctgac actaaagagc      840

tgtaagagca tagataaact gcttaagctc ttcgtgtttt tctcctttca aggtgaagtg      900

gttgatgacc taatttacag gccagaactc caaacttaca cgaagtggag aggaaaagcc      960

agtggctgat gaaggtggag taggcttaga gagaggagct gggagggcat ctgcctgcac     1020

cttgttcatt tgactccgtg tggtgtggca tcctgccaag gggtaggatt aatttgaggt     1080

gtaggtgacc aaatgcagag ctatctcttt tcctttgagc ccagctaatt ttatttccct     1140

aggactattt tgttttgctt ggctaagaaa aaccacccag ccggttacaa atatcctcat     1200

gaacctcaaa ggtcttctct gcacaatttt taattaaaga ggctaaagct aaaattggga     1260

cctacaggcc actccagtaa agacttaaag acacaaattt gatagatctt taatataact     1320

cttaaagctt taatacaact cttcaaacat aatagtaaaa attctttatt ttacaataca     1380

tgtattccta cagttagaaa gtaacaaccc cttagtccaa aaaacaaagt tataactttt     1440

tattccagaa gtaatgcatg ttttctgtaa aacaaaatta gaaaaccccc ataagcaagt     1500

aggagaaaag aaaagaaaat caccaataat ctgggataat cacaagtaga tttttgatgc     1560

atagtcttca cggttgtgtg tgtgttttgt gtacacacat aaatttaaag aaaagtggtt     1620

acatcctatc tactctattt atctaaacct ttatttcata catgaacttt cattcatgag     1680

agcttaaatt attcgctata ttacctagct agttaacagt taattgaggt cagctgactc     1740

tgaaacaaat acaagaaaaa ggcagacatg gtagatagag gtaaccaatg ttgatatctt     1800

ggtgtttttt ttctactctt aaattttttc ttctgtatct aaaaagaaaa ctccatttct     1860

tacagatttt gactactggg attatgttgt tcctgaaccc aacctcaacg aggtaatatt     1920

tgaggaatca acttgccaga atttggttaa aatgctggag aactgtctgt ccaaatcaaa     1980

gcaaactaaa cttggttgct caaaggtcct tgtccctgag aaactgaccc agagaattgc     2040

tcaagatgtc ctgcggcttt cctcaacgga gccctgcggc ttgcgaggtt gtgttatgca     2100

cgtgaacttg gaaattgaaa atgtatgtaa aaagctggat aggattgtgt gtgattctag     2160

cgtcgtacct acttttgagc ttacacttgt gtttaagcag gagaactgct catggactag     2220

cttcagggac tttttcttta gtagaggtcg cttctcctct ggtttcagga gaactctgat     2280

cctcagctca ggatttcgac ttgttaagaa aaaactttac tcactgattg gaacaacagt     2340

gattgaaggg tcctaaaaag ggaaaatata taaagattat ttcatgattg ggtagtaaaa     2400

ctattcagct agtcagctaa agtcatttgt agtttgcccc acctgcccta aataagaaac     2460

cccaaatgta gtctcttttc tttctgtgtt tcacattcat agcaactgca gctaacaggc     2520

tgattttctg gcctttggag aagtgattca aaatagtgta gattttctgc atagatccca     2580

tttttgtaca gaattgaatg ggatggaata ggtaagcaaa agtagaagcc catttgagtt     2640

ttacatttga ttccacaatt tggtttcagg taggcttggt aatagactat ataaaccaga     2700

tttgcctatt ttgattttca tatggctttt ttttctgtaa gttttcagag gattttttaa     2760

atcacagaat catactaaat gatatttagc ctatcaaaac ttccaaaagc ccacaccacc     2820

agttcctgac tcaaatttga agggttttta gacaggaggg taggattaag taggtgagtt     2880

taattaaagc ttaaccctag gtaagagtaa atgagaaata ttacggcaat aatggaactg     2940

cttcactgtt tcttggtgac ttcctcactc taatgtttta aagaggcaac aaaagcttgt     3000

ggtgccattt cagtaaccac ggtgttgttt tagatgcctt tataagctca gtttcccctg     3060

ttcttaagtg ttgaatactg tctttaaact agaaaaatgc aaaatattga actgatattt     3120

ttgtgtgtag ttgattactc ttccattgag tgaatgatga atacctgtga ggataggaaa     3180

ttagttctga gatctagtcc ctctctgatt cacttagtaa tctatcctct tttcagtatt     3240

acatgtgctt aatctcagat gaaccatttc accatggcag tgttatctca tctctgggct     3300

tttctgggaa ttgaagtatc tctccttaac cccaattgtc aagggtagta gctgtatact     3360

accactttga attattgaaa cgggtcaatt tacgaagtct gcattggcta tggagatatg     3420

gtttatagta cagcctagag aatgaaactc accgtccaga taaccatgca tgcacccaga     3480

ttttttccac cttggatacc tgtcactagg gaataataaa ggcctgattt tttgtcttat     3540

tccaactaag tagatcatta tctctttcct tttttatgtt aatgagagaa tttagcctcc     3600

actcaacaat gttcaattca gcaaggcttt catatccttg ctgtgggtcg tggataagga     3660

gcttattcag gtttcctgcc ctagctatta gctccacttc acatgctgga gaccggcgta     3720

gggacagatg tattcatcct ggtgttactg aaaaacaggt gtgatcctgt tactgatact     3780

ataagtgacc taaaatgtca ctgttcaaat tagccagtgt tctaacaaac taaactcttc     3840

aaatgcttgg aaagatacta caaagccaat ctttatagaa ttgggccaag ataaatctat     3900

gttgttttgc atggctattg ttaagctcca aaggttcact gtgtttctgc cgctgtcctg     3960

gagttgtcac cactgactgg gcaaggcttc ttgggcatgg atgtagaact gttgtccttt     4020

tcccactaac agttatcttt gactctcttg cctgttatgc ttacaaaatg gtgatggctt     4080

atggaaggct gttaaattaa tattcctgtt aaaggaaatt aaagtttgtc tatttttgac     4140

aataaaacat tatatatttt taa                                             4163


<210>  3
<211>  255
<212>  DNA
<213>  ˣHomo sapiens

<400>  3
atggttgcaa ctggcagttt gagcagcaag aacccggcca gcatttcaga attgctggac       60

tgtggctatc acccagagag cctgctaagt ggtgagtgtc cccgctgtcc acccttctcc      120

cctcccaagg tcggtgcctc tggatctatt gggtgggcgg gctttcgact tcctccccta      180

cctctatgta ggaggtgcca caaaatccat ctgaggagac tcctttccaa attttctaac      240

atcttctctc catga                                                       255


<210>  4
<211>  84
<212>  PRT
<213>  ˣHomo sapiens

<400>  4

Met Val Ala Thr Gly Ser Leu Ser Ser Lys Asn Pro Ala Ser Ile Ser 
1               5                   10                  15      


Glu Leu Leu Asp Cys Gly Tyr His Pro Glu Ser Leu Leu Ser Gly Glu 
            20                  25                  30          


Cys Pro Arg Cys Pro Pro Phe Ser Pro Pro Lys Val Gly Ala Ser Gly 
        35                  40                  45              


Ser Ile Gly Trp Ala Gly Phe Arg Leu Pro Pro Leu Pro Leu Cys Arg 
    50                  55                  60                  


Arg Cys His Lys Ile His Leu Arg Arg Leu Leu Ser Lys Phe Ser Asn 
65                  70                  75                  80  


Ile Phe Ser Pro 
                


<210>  5
<211>  582
<212>  DNA
<213>  ˣHomo sapiens

<400>  5
atggttgcaa ctggcagttt gagcagcaag aacccggcca gcatttcaga attgctggac       60

tgtggctatc acccagagag cctgctaagt gattttgact actgggatta tgttgttcct      120

gaacccaacc tcaacgaggt aatatttgag gaatcaactt gccagaattt ggttaaaatg      180

ctggagaact gtctgtccaa atcaaagcaa actaaacttg gttgctcaaa ggtccttgtc      240

cctgagaaac tgacccagag aattgctcaa gatgtcctgc ggctttcctc aacggagccc      300

tgcggcttgc gaggttgtgt tatgcacgtg aacttggaaa ttgaaaatgt atgtaaaaag      360

ctggatagga ttgtgtgtga ttctagcgtc gtacctactt ttgagcttac acttgtgttt      420

aagcaggaga actgctcatg gactagcttc agggactttt tctttagtag aggtcgcttc      480

tcctctggtt tcaggagaac tctgatcctc agctcaggat ttcgacttgt taagaaaaaa      540

ctttactcac tgattggaac aacagtgatt gaagggtcct aa                         582


<210>  6
<211>  193
<212>  PRT
<213>  ˣHomo sapiens

<400>  6

Met Val Ala Thr Gly Ser Leu Ser Ser Lys Asn Pro Ala Ser Ile Ser 
1               5                   10                  15      


Glu Leu Leu Asp Cys Gly Tyr His Pro Glu Ser Leu Leu Ser Asp Phe 
            20                  25                  30          


Asp Tyr Trp Asp Tyr Val Val Pro Glu Pro Asn Leu Asn Glu Val Ile 
        35                  40                  45              


Phe Glu Glu Ser Thr Cys Gln Asn Leu Val Lys Met Leu Glu Asn Cys 
    50                  55                  60                  


Leu Ser Lys Ser Lys Gln Thr Lys Leu Gly Cys Ser Lys Val Leu Val 
65                  70                  75                  80  


Pro Glu Lys Leu Thr Gln Arg Ile Ala Gln Asp Val Leu Arg Leu Ser 
                85                  90                  95      


Ser Thr Glu Pro Cys Gly Leu Arg Gly Cys Val Met His Val Asn Leu 
            100                 105                 110         


Glu Ile Glu Asn Val Cys Lys Lys Leu Asp Arg Ile Val Cys Asp Ser 
        115                 120                 125             


Ser Val Val Pro Thr Phe Glu Leu Thr Leu Val Phe Lys Gln Glu Asn 
    130                 135                 140                 


Cys Ser Trp Thr Ser Phe Arg Asp Phe Phe Phe Ser Arg Gly Arg Phe 
145                 150                 155                 160 


Ser Ser Gly Phe Arg Arg Thr Leu Ile Leu Ser Ser Gly Phe Arg Leu 
                165                 170                 175     


Val Lys Lys Lys Leu Tyr Ser Leu Ile Gly Thr Thr Val Ile Glu Gly 
            180                 185                 190         


Ser 
    


