                         б

<110>  ʵ＼ɷ޹˾
       ٰͼҽҩƼɷ޹˾
 
<120>  B7-H3Ŀ弰;

<130>  55556 00070

<160>  75    

<170>  PatentIn汾3.5

<210>  1
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  6B515F11VH-CDR1

<400>  1

Ser Gly Gly Tyr Tyr Trp Ser 
1               5           


<210>  2
<211>  16
<212>  PRT
<213>  ˹

<220>
<223>  6B5VH-CDR2

<400>  2

Tyr Ile Tyr Tyr Ser Gly Gly Thr Tyr Tyr Ser Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  3
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  6B5VH-CDR3

<400>  3

Arg Ala Gly Tyr Ser Ser Ser Phe Asp Ser 
1               5                   10  


<210>  4
<211>  16
<212>  PRT
<213>  ˹

<220>
<223>  6B5VL-CDR1

<400>  4

Arg Ser Ser Gln Ser Leu Leu Tyr Ser Asn Gly Tyr Thr Tyr Leu Asp 
1               5                   10                  15      


<210>  5
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  6B5VL-CDR2

<400>  5

Leu Gly Phe Asn Arg Ala Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  6B5VL-CDR3

<400>  6

Met Gln Gly Leu Gln Thr Pro Tyr Thr 
1               5                   


<210>  7
<211>  16
<212>  PRT
<213>  ˹

<220>
<223>  15F11VH-CDR2

<400>  7

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  8
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  15F11VH-CDR3

<400>  8

Glu Arg Ile Ala Val Ala Gly Tyr Phe Asp Tyr 
1               5                   10      


<210>  9
<211>  12
<212>  PRT
<213>  ˹

<220>
<223>  15F1110F7VL-CDR1

<400>  9

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  10
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  15F11VL-CDR2

<400>  10

Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210>  11
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  15F11VL-CDR3

<400>  11

Gln Gln Tyr Gly Ser Ser Pro Leu Thr 
1               5                   


<210>  12
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  10D7VH-CDR1

<400>  12

Arg Ser Ser Tyr Tyr Trp Gly 
1               5           


<210>  13
<211>  16
<212>  PRT
<213>  ˹

<220>
<223>  10D7VH-CDR2

<400>  13

Asn Ile Phe Tyr Ala Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  14
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  10D7VH-CDR3

<400>  14

Arg Ile Thr Gly Thr Thr Gly Trp Phe Asp Pro 
1               5                   10      


<210>  15
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  10D7VL-CDR1

<400>  15

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  16
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  10D7VL-CDR2

<400>  16

Ala Ala Ser Thr Leu Gln Ser 
1               5           


<210>  17
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  10D7VL-CDR3

<400>  17

Leu Gln Asp Tyr Asn Tyr Pro Arg Thr 
1               5                   


<210>  18
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  10F7VH-CDR1

<400>  18

Ser Ser Ser Ala Ala Trp Asn 
1               5           


<210>  19
<211>  18
<212>  PRT
<213>  ˹

<220>
<223>  10F7VH-CDR2

<400>  19

Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Phe Ala Val Ser Val 
1               5                   10                  15      


Lys Ser 
        


<210>  20
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  10F7VH-CDR3

<400>  20

Asp Leu Ile Thr Leu Val Arg Gly Val Ile Leu Pro Phe Asp Tyr 
1               5                   10                  15  


<210>  21
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  10F7VL-CDR2

<400>  21

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  22
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  10F7VL-CDR3

<400>  22

Gln Gln Tyr Gly Ser Ser His Thr 
1               5               


<210>  23
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  10F5VH-CDR1

<400>  23

Ser Gln Ala Ile Ser 
1               5   


<210>  24
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  10F5VH-CDR2

<400>  24

Arg Ile Ile Pro Met Leu Gly Ile Gly Asp Tyr Ala Gln Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  25
<211>  16
<212>  PRT
<213>  ˹

<220>
<223>  10F5VH-CDR3

<400>  25

Glu Gly Ile Ala Ala Leu Gly Thr Asn Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


<210>  26
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  10F5VL-CDR1

<400>  26

Arg Ala Ser Gln Gly Ile Ser Arg Trp Leu Ala 
1               5                   10      


<210>  27
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  10F5VL-CDR2

<400>  27

Val Ala Ser Ser Leu Gln Ser 
1               5           


<210>  28
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  10F5VL-CDR3

<400>  28

Gln Gln Ala Asn Ser Phe Pro Phe Thr 
1               5                   


<210>  29
<211>  120
<212>  PRT
<213>  ˹

<220>
<223>  6B5VH

<400>  29

Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Asp Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Gly Thr Tyr Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Ala Gly Tyr Ser Ser Ser Phe Asp Ser Trp Gly Gln 
            100                 105                 110         


Gly Ile Leu Val Thr Val Ser Ser 
        115                 120 


<210>  30
<211>  112
<212>  PRT
<213>  ˹

<220>
<223>  6B5VL

<400>  30

Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asn Gly Tyr Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Phe Leu Ile Tyr Leu Gly Phe Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  31
<211>  121
<212>  PRT
<213>  ˹

<220>
<223>  15F11VH

<400>  31

Glu Val Gln Leu Val Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Asn Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Arg Ile Ala Val Ala Gly Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  32
<211>  108
<212>  PRT
<213>  ˹

<220>
<223>  15F11VL

<400>  32

Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Ser Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Glu Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  33
<211>  121
<212>  PRT
<213>  ˹

<220>
<223>  10D7VH

<400>  33

Gln Val Gln Leu Val Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Arg Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Asn Ile Phe Tyr Ala Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Ile Thr Gly Thr Thr Gly Trp Phe Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  34
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  10D7VL

<400>  34

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  35
<211>  127
<212>  PRT
<213>  ˹

<220>
<223>  10F7VH

<400>  35

Gln Val Gln Leu Val Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Ser 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Phe Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Asp Leu Ile Thr Leu Val Arg Gly Val Ile Leu 
            100                 105                 110         


Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  36
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  10F7VL

<400>  36

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser His 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Asn Leu Glu Ile Lys 
            100                 105         


<210>  37
<211>  125
<212>  PRT
<213>  ˹

<220>
<223>  10F5VH

<400>  37

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Gln 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Met Leu Gly Ile Gly Asp Tyr Ala Gln Ser Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Val Ser Ser Leu Gly Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Ile Ala Ala Leu Gly Thr Asn Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Ala Val Thr Val Ser Ser 
        115                 120                 125 


<210>  38
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  10F5VL

<400>  38

Glu Ile Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Arg 
            100                 105         


<210>  39
<211>  122
<212>  PRT
<213>  ˹

<220>
<223>  ŵ鵥VH

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Asp Ser Ser Ala Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Gly Arg Glu Asn Ile Tyr Tyr Gly Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  40
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  ŵ鵥VL

<400>  40

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  41
<211>  118
<212>  PRT
<213>  ˹

<220>
<223>  OmburtamabVH

<400>  41

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Thr Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gln Thr Thr Ala Thr Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  42
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  OmburtamabVL

<400>  42

Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 
65                  70                  75                  80  


Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  43
<211>  330
<212>  PRT
<213>  ˹

<220>
<223>  IgG1㶨Ұͣ

<400>  43

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  44
<211>  330
<212>  PRT
<213>  ˹

<220>
<223>  IgG1-Mut㶨

<400>  44

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Val Gly Gly Pro Ser Val Phe Leu Leu Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Pro Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Leu Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Leu Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  45
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  ˦ʺ㶨

<400>  45

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  46
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  6B5VH-CDR1

<400>  46

Asp Gly Ser Ile Ser Ser Gly Gly Tyr 
1               5                   


<210>  47
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  6B5VH-CDR2

<400>  47

Tyr Tyr Ser Gly Gly 
1               5   


<210>  48
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  6B5VH-CDR3

<400>  48

Arg Ala Gly Tyr Ser Ser Ser Phe Asp Ser 
1               5                   10  


<210>  49
<211>  16
<212>  PRT
<213>  ˹

<220>
<223>  6B5VL-CDR1

<400>  49

Arg Ser Ser Gln Ser Leu Leu Tyr Ser Asn Gly Tyr Thr Tyr Leu Asp 
1               5                   10                  15      


<210>  50
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  6B5VL-CDR2

<400>  50

Leu Gly Phe Asn Arg Ala Ser 
1               5           


<210>  51
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  6B5VL-CDR3

<400>  51

Met Gln Gly Leu Gln Thr Pro Tyr Thr 
1               5                   


<210>  52
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  15F11VH-CDR1

<400>  52

Gly Gly Ser Ile Asn Ser Gly Gly Tyr 
1               5                   


<210>  53
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  15F11VH-CDR2

<400>  53

Tyr Tyr Ser Gly Ser 
1               5   


<210>  54
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  15F11VH-CDR3

<400>  54

Glu Arg Ile Ala Val Ala Gly Tyr Phe Asp Tyr 
1               5                   10      


<210>  55
<211>  12
<212>  PRT
<213>  ˹

<220>
<223>  15F11VL-CDR1

<400>  55

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  56
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  15F11VL-CDR2

<400>  56

Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210>  57
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  15F11VL-CDR3

<400>  57

Gln Gln Tyr Gly Ser Ser Pro Leu Thr 
1               5                   


<210>  58
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  10D7VH-CDR1

<400>  58

Gly Gly Ser Ile Ser Arg Ser Ser Tyr 
1               5                   


<210>  59
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  10D7VH-CDR2

<400>  59

Phe Tyr Ala Gly Ser 
1               5   


<210>  60
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  10D7VH-CDR3

<400>  60

Arg Ile Thr Gly Thr Thr Gly Trp Phe Asp Pro 
1               5                   10      


<210>  61
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  10D7VL-CDR1

<400>  61

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  62
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  10D7VL-CDR2

<400>  62

Ala Ala Ser Thr Leu Gln Ser 
1               5           


<210>  63
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  10D7VL-CDR3

<400>  63

Leu Gln Asp Tyr Asn Tyr Pro Arg Thr 
1               5                   


<210>  64
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  10F7VH-CDR1

<400>  64

Gly Asp Ser Val Ser Ser Ser Ser Ala 
1               5                   


<210>  65
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  10F7VH-CDR2

<400>  65

Tyr Tyr Arg Ser Lys Trp Tyr 
1               5           


<210>  66
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  10F7VH-CDR3

<400>  66

Asp Leu Ile Thr Leu Val Arg Gly Val Ile Leu Pro Phe Asp Tyr 
1               5                   10                  15  


<210>  67
<211>  12
<212>  PRT
<213>  ˹

<220>
<223>  10F7VL-CDR1

<400>  67

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  68
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  10F7VL-CDR2

<400>  68

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  69
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  10F7VL-CDR3

<400>  69

Gln Gln Tyr Gly Ser Ser His Thr 
1               5               


<210>  70
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  10F5VH-CDR1

<400>  70

Gly Gly Thr Phe Ser Ser Gln 
1               5           


<210>  71
<211>  6
<212>  PRT
<213>  ˹

<220>
<223>  10F5VH-CDR2

<400>  71

Ile Pro Met Leu Gly Ile 
1               5       


<210>  72
<211>  16
<212>  PRT
<213>  ˹

<220>
<223>  10F5VH-CDR3

<400>  72

Glu Gly Ile Ala Ala Leu Gly Thr Asn Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


<210>  73
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  10F5VL-CDR1

<400>  73

Arg Ala Ser Gln Gly Ile Ser Arg Trp Leu Ala 
1               5                   10      


<210>  74
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  10F5VL-CDR2

<400>  74

Val Ala Ser Ser Leu Gln Ser 
1               5           


<210>  75
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  10F5VL-CDR3

<400>  75

Gln Gln Ala Asn Ser Phe Pro Phe Thr 
1               5                   


