                         SEQUENCE LISTING

<110>  Ϻѱ¹＼޹˾
 
<120>  GPRC5DȫԴǶϿԭ(CAR)Ӧ

<130>  P11035-PCT

<160>  39    

<170>  PatentIn version 3.3

<210>  1
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  #18 CDR1

<400>  1

Gly Gly Ser Phe Ser Gly Tyr Tyr 
1               5               


<210>  2
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  #18 CDR2

<400>  2

Ile Asn His Ser Gly Ser Thr 
1               5           


<210>  3
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  #18 CDR3

<400>  3

Ala Arg Ala Arg Arg Tyr Gly Gly Arg Thr Arg Phe Asp Pro 
1               5                   10                  


<210>  4
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  #39 CDR1

<400>  4

Gly Phe Ile Phe Ser Ser Tyr Gly 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  #39 CDR2

<400>  5

Ile Ser Ser Ser Gly Asp Tyr Thr 
1               5               


<210>  6
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  #39 CDR3

<400>  6

Ala Arg Met Ser Phe Arg Arg Tyr Asp His 
1               5                   10  


<210>  7
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  #41 CDR1

<400>  7

Gly Phe Ser Phe Ser Gly Tyr Ile 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  #41 CDR2

<400>  8

Thr Ser Ser Ser Gly Thr Glu Thr 
1               5               


<210>  9
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  #41 CDR3

<400>  9

Ala Arg Tyr Tyr Ser Lys Tyr Gly Arg Ser Tyr His Val Asp Ser 
1               5                   10                  15  


<210>  10
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  #18 VHH 

<400>  10

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Arg Arg Tyr Gly Gly Arg Thr Arg Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  11
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  #39 VHH 

<400>  11

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Gly Asp Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Met Ser Phe Arg Arg Tyr Asp His Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  12
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  #41 VHH 

<400>  12

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Gly Tyr 
            20                  25                  30          


Ile Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Thr Ser Ser Ser Gly Thr Glu Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Ser Lys Tyr Gly Arg Ser Tyr His Val Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  13
<211>  360
<212>  DNA
<213>  Artificial

<220>
<223>  #18 VHH 

<400>  13
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc     60

acctgcgctg tctatggtgg gtccttcagt ggttactact ggagctggat ccgccagccc    120

ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaagcac caactacaac    180

ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg    240

aagctgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag ggcccgacgc    300

tacggtggcc gaaccaggtt cgacccctgg ggccagggaa ccctggtcac cgtctcctca    360


<210>  14
<211>  351
<212>  DNA
<213>  Artificial

<220>
<223>  #39 VHH 

<400>  14
gaagttcagc tgctggaaag cggtggtggt ctggttcagc ctggtggtag cctgcgtctg     60

agctgtgcag caagcggttt tatctttagc agctatggca tgggttgggt tcgtcaggca    120

cctggtaaag gtctggaatg ggttagcagc atcagcagca gcggcgatta tacctattat    180

gcagatagcg ttaaaggtcg ttttaccatt agccgtgata acagcaaaaa taccctgtac    240

ctgcagatga atagtctgcg tgcagaggat accgcagtgt attattgtgc gcgcatgtct    300

ttccgtcgtt acgatcattg gggtcaaggt actctggtga ccgtctcctc a             351


<210>  15
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  #41 VHH 

<400>  15
gaagttcagc tgctggaaag cggtggtggt ctggttcagc ctggtggtag cctgcgtctg     60

agctgtgcag caagcggttt tagctttagc ggctatatca tgggttgggt tcgtcaggca    120

cctggtaaag gtctggaatg ggttagcagc accagcagca gcggcaccga aacctattat    180

gcagatagcg ttaaaggtcg ttttaccatt agccgtgata acagcaaaaa taccctgtac    240

ctgcagatga atagtctgcg tgcagaggat accgcagtgt attattgtgc gcgctactac    300

tctaaatacg gtcgttctta ccatgttgat tcttggggtc aaggtactct ggtgaccgtc    360

tcctca                                                               366


<210>  16
<211>  63
<212>  DNA
<213>  Artificial

<220>
<223>  CD8źı 63 bp

<400>  16
atggccctgc ctgtgacagc tctgctcctc cctctggccc tgctgctcca tgccgccaga     60

ccc                                                                   63


<210>  17
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  CD8ź  21 aa

<400>  17

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  18
<211>  165
<212>  DNA
<213>  Artificial

<220>
<223>  CD8  165 bp

<400>  18
ttcgtgcccg tgttcctgcc cgccaaacct actactaccc ctgcacctag gcctcccacc     60

ccagccccaa caatcgccag ccagcctctg tctctgcggc ccgaagcctg tagacctgct    120

gccggcggag ccgtgcacac cagaggcctg gacttcgcct gcgac                    165


<210>  19
<211>  55
<212>  PRT
<213>  Artificial

<220>
<223>  CD8  55 aa

<400>  19

Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Cys Asp 
    50                  55  


<210>  20
<211>  84
<212>  DNA
<213>  Artificial

<220>
<223>  CD8Ĥ 84 bp

<400>  20
atctacatct gggcccctct ggccggcacc tgtggcgtgc tgctgctgag cctggtgatc     60

accctgtact gcaaccaccg gaac                                            84


<210>  21
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  CD8Ĥ  28 aa

<400>  21

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn 
            20                  25              


<210>  22
<211>  126
<212>  DNA
<213>  Artificial

<220>
<223>  4-1BB ڽṹ 126 bp

<400>  22
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa     60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt    120

gaactg                                                               126


<210>  23
<211>  42
<212>  PRT
<213>  Artificial

<220>
<223>  4-1BB ڽṹ򵰰 42 aa

<400>  23

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  24
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  CD3 źŽṹ 336 bp

<400>  24
agagtgaagt tcagcagatc cgccgacgcc cctgcctacc agcagggaca gaaccagctg     60

tacaacgagc tgaacctggg cagacgggaa gagtacgacg tgctggacaa gcggagaggc    120

cgggaccccg agatgggcgg aaagcccaga cggaagaacc cccaggaagg cctgtataac    180

gaactgcaga aagacaagat ggccgaggcc tacagcgaga tcggcatgaa gggcgagcgg    240

aggcgcggca agggccacga tggcctgtac cagggcctga gcaccgccac caaggacacc    300

tacgacgccc tgcacatgca ggccctgccc cccaga                              336


<210>  25
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  CD3 źŽṹ򵰰 112 aa

<400>  25

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  26
<211>  54
<212>  DNA
<213>  Artificial

<220>
<223>  T2A 54 bp

<400>  26
gagggaaggg gcagcttatt aacatgtggc gatgtggaag agaaccccgg tccc           54


<210>  27
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  T2A 18 aa

<400>  27

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  28
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  CSF2RA signal 66 bp

<400>  28
atgctgctgc tcgtgacctc tttactgtta tgtgagctgc cccaccccgc ttttttactg     60

atccct                                                                66


<210>  29
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  CSF2RA signal 22 aa

<400>  29

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  30
<211>  1005
<212>  DNA
<213>  Artificial

<220>
<223>  EGFRt 1005 bp

<400>  30
cgtaaggtgt gtaacggaat cggcattggc gagttcaagg actctttaag catcaacgcc     60

acaaacatca agcacttcaa gaattgtacc tccatcagcg gcgatttaca cattctcccc    120

gtggcttttc gtggcgattc cttcacccac accccccctc tggaccccca agagctggac    180

attttaaaaa ccgtgaagga gatcaccggc tttctgctga tccaagcttg gcccgagaat    240

cgtaccgacc tccacgcctt cgagaattta gagattattc gtggaaggac caagcagcac    300

ggccagttct ctttagccgt cgtgtcttta aacattacca gcctcggttt aaggtcttta    360

aaggagatta gcgacggcga cgtgatcatc tccggcaaca agaacctctg ctacgccaac    420

accatcaact ggaagaagct gttcggaacc agcggccaaa agaccaagat catcagcaat    480

cgtggagaga actcttgtaa ggccactggt caagtttgcc acgccctctg tagccccgaa    540

ggatgttggg gccccgagcc tagggactgt gttagctgca gaaacgtgag cagaggcaga    600

gagtgtgtgg acaaatgcaa tttactggaa ggagagccta gggagttcgt ggagaacagc    660

gaatgtatcc agtgccaccc cgagtgttta cctcaagcca tgaacatcac ttgtaccgga    720

aggggccccg ataactgcat ccaatgcgcc cactacatcg acggacccca ctgcgtgaaa    780

acttgtcccg ccggagtgat gggagagaat aacactttag tgtggaagta cgccgacgct    840

ggccacgtct gccatctgtg ccaccccaac tgtacctacg gctgcactgg tcccggttta    900

gagggatgtc ctaccaacgg ccccaagatc ccctccatcg ccaccggaat ggtgggcgct    960

ctgttattac tgctggtggt ggctctgggc atcggtttat tcatg                   1005


<210>  31
<211>  335
<212>  PRT
<213>  Artificial

<220>
<223>  EGFRt 335 aa

<400>  31

Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
1               5                   10                  15      


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
            20                  25                  30          


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
        35                  40                  45              


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
    50                  55                  60                  


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
65                  70                  75                  80  


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
                85                  90                  95      


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
            100                 105                 110         


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
        115                 120                 125             


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
    130                 135                 140                 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
145                 150                 155                 160 


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
                165                 170                 175     


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
            180                 185                 190         


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
        195                 200                 205             


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
    210                 215                 220                 


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
225                 230                 235                 240 


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
                245                 250                 255     


His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
            260                 265                 270         


Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His 
        275                 280                 285             


Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro 
    290                 295                 300                 


Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala 
305                 310                 315                 320 


Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met 
                325                 330                 335 


<210>  32
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  P2Aĺ 57 bp

<400>  32
gctactaact tcagcctgct gaagcaggct ggtgacgtcg aggagaatcc tggcccc        57


<210>  33
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  P2Aĵ 19 aa

<400>  33

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  34
<211>  1134
<212>  DNA
<213>  Artificial

<220>
<223>  GPRC5D CAR 2290(#18)  1134bp

<400>  34
atggccctgc ctgtgacagc tctgctcctc cctctggccc tgctgctcca tgccgccaga     60

ccccaggtgc agctacagca gtggggcgca ggactgttga agccttcgga gaccctgtcc    120

ctcacctgcg ctgtctatgg tgggtccttc agtggttact actggagctg gatccgccag    180

cccccaggga aggggctgga gtggattggg gaaatcaatc atagtggaag caccaactac    240

aacccgtccc tcaagagtcg agtcaccata tcagtagaca cgtccaagaa ccagttctcc    300

ctgaagctga gctctgtgac cgccgcggac acggctgtgt attactgtgc gagggcccga    360

cgctacggtg gccgaaccag gttcgacccc tggggccagg gaaccctggt caccgtctcc    420

tcattcgtgc ccgtgttcct gcccgccaaa cctactacta cccctgcacc taggcctccc    480

accccagccc caacaatcgc cagccagcct ctgtctctgc ggcccgaagc ctgtagacct    540

gctgccggcg gagccgtgca caccagaggc ctggacttcg cctgcgacat ctacatctgg    600

gcccctctgg ccggcacctg tggcgtgctg ctgctgagcc tggtgatcac cctgtactgc    660

aaccaccgga acaaacgggg cagaaagaaa ctcctgtata tattcaaaca accatttatg    720

agaccagtac aaactactca agaggaagat ggctgtagct gccgatttcc agaagaagaa    780

gaaggaggat gtgaactgag agtgaagttc agcagatccg ccgacgcccc tgcctaccag    840

cagggacaga accagctgta caacgagctg aacctgggca gacgggaaga gtacgacgtg    900

ctggacaagc ggagaggccg ggaccccgag atgggcggaa agcccagacg gaagaacccc    960

caggaaggcc tgtataacga actgcagaaa gacaagatgg ccgaggccta cagcgagatc   1020

ggcatgaagg gcgagcggag gcgcggcaag ggccacgatg gcctgtacca gggcctgagc   1080

accgccacca aggacaccta cgacgccctg cacatgcagg ccctgccccc caga         1134


<210>  35
<211>  378
<212>  PRT
<213>  Artificial

<220>
<223>  GPRC5D CAR 2290(#18)  378aa

<400>  35

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu 
            20                  25                  30          


Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly 
        35                  40                  45              


Ser Phe Ser Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ala Arg Arg Tyr Gly Gly Arg Thr Arg Phe 
        115                 120                 125             


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Phe Val Pro 
    130                 135                 140                 


Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro 
145                 150                 155                 160 


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
                165                 170                 175     


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
            180                 185                 190         


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
        195                 200                 205             


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn 
    210                 215                 220                 


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
225                 230                 235                 240 


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
                245                 250                 255     


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
            260                 265                 270         


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
        275                 280                 285             


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
    290                 295                 300                 


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
305                 310                 315                 320 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
                325                 330                 335     


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
            340                 345                 350         


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
        355                 360                 365             


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    370                 375             


<210>  36
<211>  1125
<212>  DNA
<213>  Artificial

<220>
<223>  GPRC5D CAR 2436(#39)  1125bp

<400>  36
atggccctgc ctgtgacagc tctgctcctc cctctggccc tgctgctcca tgccgccaga     60

cccgaagttc agctgctgga aagcggtggt ggtctggttc agcctggtgg tagcctgcgt    120

ctgagctgtg cagcaagcgg ttttatcttt agcagctatg gcatgggttg ggttcgtcag    180

gcacctggta aaggtctgga atgggttagc agcatcagca gcagcggcga ttatacctat    240

tatgcagata gcgttaaagg tcgttttacc attagccgtg ataacagcaa aaataccctg    300

tacctgcaga tgaatagtct gcgtgcagag gataccgcag tgtattattg tgcgcgcatg    360

tctttccgtc gttacgatca ttggggtcaa ggtactctgg tgaccgtctc ctcattcgtg    420

cccgtgttcc tgcccgccaa acctactact acccctgcac ctaggcctcc caccccagcc    480

ccaacaatcg ccagccagcc tctgtctctg cggcccgaag cctgtagacc tgctgccggc    540

ggagccgtgc acaccagagg cctggacttc gcctgcgaca tctacatctg ggcccctctg    600

gccggcacct gtggcgtgct gctgctgagc ctggtgatca ccctgtactg caaccaccgg    660

aacaaacggg gcagaaagaa actcctgtat atattcaaac aaccatttat gagaccagta    720

caaactactc aagaggaaga tggctgtagc tgccgatttc cagaagaaga agaaggagga    780

tgtgaactga gagtgaagtt cagcagatcc gccgacgccc ctgcctacca gcagggacag    840

aaccagctgt acaacgagct gaacctgggc agacgggaag agtacgacgt gctggacaag    900

cggagaggcc gggaccccga gatgggcgga aagcccagac ggaagaaccc ccaggaaggc    960

ctgtataacg aactgcagaa agacaagatg gccgaggcct acagcgagat cggcatgaag   1020

ggcgagcgga ggcgcggcaa gggccacgat ggcctgtacc agggcctgag caccgccacc   1080

aaggacacct acgacgccct gcacatgcag gccctgcccc ccaga                   1125


<210>  37
<211>  375
<212>  PRT
<213>  Artificial

<220>
<223>  GPRC5D CAR 2436(#39)  375aa

<400>  37

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Ile Phe Ser Ser Tyr Gly Met Gly Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Ser Ile Ser Ser Ser Gly Asp Tyr Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Met Ser Phe Arg Arg Tyr Asp His Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Phe Val Pro Val Phe Leu 
    130                 135                 140                 


Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
145                 150                 155                 160 


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
                165                 170                 175     


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
            180                 185                 190         


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
        195                 200                 205             


Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Lys Arg Gly 
    210                 215                 220                 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
225                 230                 235                 240 


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
                245                 250                 255     


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
            260                 265                 270         


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
        275                 280                 285             


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
    290                 295                 300                 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
305                 310                 315                 320 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                325                 330                 335     


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            340                 345                 350         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        355                 360                 365             


Met Gln Ala Leu Pro Pro Arg 
    370                 375 


<210>  38
<211>  1140
<212>  DNA
<213>  Artificial

<220>
<223>  GPRC5D CAR 2438(#41)  1140bp

<400>  38
atggccctgc ctgtgacagc tctgctcctc cctctggccc tgctgctcca tgccgccaga     60

cccgaagttc agctgctgga aagcggtggt ggtctggttc agcctggtgg tagcctgcgt    120

ctgagctgtg cagcaagcgg ttttagcttt agcggctata tcatgggttg ggttcgtcag    180

gcacctggta aaggtctgga atgggttagc agcaccagca gcagcggcac cgaaacctat    240

tatgcagata gcgttaaagg tcgttttacc attagccgtg ataacagcaa aaataccctg    300

tacctgcaga tgaatagtct gcgtgcagag gataccgcag tgtattattg tgcgcgctac    360

tactctaaat acggtcgttc ttaccatgtt gattcttggg gtcaaggtac tctggtgacc    420

gtctcctcat tcgtgcccgt gttcctgccc gccaaaccta ctactacccc tgcacctagg    480

cctcccaccc cagccccaac aatcgccagc cagcctctgt ctctgcggcc cgaagcctgt    540

agacctgctg ccggcggagc cgtgcacacc agaggcctgg acttcgcctg cgacatctac    600

atctgggccc ctctggccgg cacctgtggc gtgctgctgc tgagcctggt gatcaccctg    660

tactgcaacc accggaacaa acggggcaga aagaaactcc tgtatatatt caaacaacca    720

tttatgagac cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa    780

gaagaagaag gaggatgtga actgagagtg aagttcagca gatccgccga cgcccctgcc    840

taccagcagg gacagaacca gctgtacaac gagctgaacc tgggcagacg ggaagagtac    900

gacgtgctgg acaagcggag aggccgggac cccgagatgg gcggaaagcc cagacggaag    960

aacccccagg aaggcctgta taacgaactg cagaaagaca agatggccga ggcctacagc   1020

gagatcggca tgaagggcga gcggaggcgc ggcaagggcc acgatggcct gtaccagggc   1080

ctgagcaccg ccaccaagga cacctacgac gccctgcaca tgcaggccct gccccccaga   1140


<210>  39
<211>  380
<212>  PRT
<213>  Artificial

<220>
<223>  GPRC5D CAR 2438(#41)  380aa

<400>  39

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Ser Phe Ser Gly Tyr Ile Met Gly Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Ser Thr Ser Ser Ser Gly Thr Glu Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Ser Lys Tyr Gly Arg Ser Tyr 
        115                 120                 125             


His Val Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Phe 
    130                 135                 140                 


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
145                 150                 155                 160 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
                165                 170                 175     


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
            180                 185                 190         


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
        195                 200                 205             


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
    210                 215                 220                 


Arg Asn Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
225                 230                 235                 240 


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
                245                 250                 255     


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
            260                 265                 270         


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
        275                 280                 285             


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
    290                 295                 300                 


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
305                 310                 315                 320 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
                325                 330                 335     


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
            340                 345                 350         


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
        355                 360                 365             


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    370                 375                 380 


