   SEQUENCE LISTING

<110>  Adlai Nortye Biopharma Co., Ltd.

<120>  ANTI-TNFR2 ANTIBODY AND APPLICATION THEREOF

<130>  OP220255

<160>  49

<170>  PatentIn version 3.5

<210>  1
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  1

Gln Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Ser 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Gly Ser Gly Gly Thr Ser Tyr Tyr Ser Asn Trp Ala Lys 
    50                  55                  60                  


Ser Arg Ser Thr Ile Thr Arg Asp Thr Asn Leu Asn Thr Val Thr Leu 
65                  70                  75                  80  


Lys Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Asp Pro Asn Ser Ser Asp Tyr Pro Tyr Gly Ala Tyr Gly Met Gly 
            100                 105                 110         


Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  2
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  2

Ala Glu Leu Asp Leu Thr Gln Thr Pro Ala Ser Val Glu Val Ala Ala 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Asn Cys Gln Val Ser Gln Ser Ile Ser Ser 
            20                  25                  30          


Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Val Gln 
65                  70                  75                  80  


Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ile Thr Ser 
                85                  90                  95      


Asn Val Gly Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110     


<210>  3
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Ser 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Gly Ser Gly Gly Thr Ser Tyr Tyr Ser Asn Trp Ala Lys 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Pro Asn Ser Ser Asp Tyr Pro Tyr Gly Ala Tyr Gly Met Gly 
            100                 105                 110         


Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  4
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  4

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Ser 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Gly Ser Gly Gly Thr Ser Tyr Tyr Ser Asn Trp Ala Lys 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Asp Pro Asn Ser Ser Asp Tyr Pro Tyr Gly Ala Tyr Gly Met Gly 
            100                 105                 110         


Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  5
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Ser 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Gly Ser Gly Gly Thr Ser Tyr Tyr Ser Asn Trp Ala Lys 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Asp Pro Asn Ser Ser Asp Tyr Pro Tyr Gly Ala Tyr Gly Met Gly 
            100                 105                 110         


Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  6
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  6

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Ser 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Gly Ser Gly Gly Thr Ser Tyr Tyr Ser Asn Trp Ala Lys 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Pro Asn Ser Ser Asp Tyr Pro Tyr Gly Ala Tyr Gly Met Gly 
            100                 105                 110         


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  7
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Ser 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Gly Ser Gly Gly Thr Ser Tyr Tyr Ser Asn Trp Ala Lys 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Pro Asn Ser Ser Asp Tyr Pro Tyr Gly Ala Tyr Gly Met Gly 
            100                 105                 110         


Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  8
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Val Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ile Thr Ser Asn 
                85                  90                  95      


Val Gly Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  9
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Val Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ile Thr Ser Asn 
                85                  90                  95      


Val Gly Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  10
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Val Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ile Thr Ser Asn 
                85                  90                  95      


Val Gly Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  11
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  11

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Val Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ile Thr Ser Asn 
                85                  90                  95      


Val Gly Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  12
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR1

<400>  12

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1

<400>  13

Gly Phe Ser Leu Ser Ser Ser Ala 
1               5               


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR2

<400>  14

Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Ala 
    


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  15

Ile Gly Ser Gly Gly Thr Ser 
1               5           


<210>  16
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR3

<400>  16

Tyr Tyr Ser Asn Trp Ala Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  17
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3

<400>  17

Ala Arg Asp Pro Asn Ser Ser Asp Tyr Pro Tyr Gly Ala Tyr Gly Met 
1               5                   10                  15      


Gly Leu 
        


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR4

<400>  18

Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  19
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR3

<400>  19

Tyr Tyr Ser Asn Trp Ala Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Phe Cys 
        35              


<210>  20
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR3

<400>  20

Tyr Tyr Ser Asn Trp Ala Lys Ser Arg Phe Thr Ile Ser Arg Asp Thr 
1               5                   10                  15      


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Phe Cys 
        35              


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR4

<400>  21

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  22
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR1

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  23
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR4

<400>  23

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  24
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR1

<400>  24

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Val Ser 
            20                  25      


<210>  25
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1

<400>  25

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  26
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR2

<400>  26

Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  27
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2

<400>  27

Tyr Ala Ser 
1           


<210>  28
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR3

<400>  28

Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  29
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  29

Gln Gln Gly Tyr Ile Thr Ser Asn Val Gly Asn Ala 
1               5                   10          


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR4

<400>  30

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  31
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR2

<400>  31

Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  32
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR1

<400>  32

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Val Ser 
            20                  25      


<210>  33
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR1

<400>  33

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Val Ser 
            20                  25      


<210>  34
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR3

<400>  34

Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  35
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR1

<400>  35

Gln Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser 
            20                  25  


<210>  36
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR2

<400>  36

Val Ser Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Ala 
    


<210>  37
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR3

<400>  37

Tyr Tyr Ser Asn Trp Ala Lys Ser Arg Ser Thr Ile Thr Arg Asp Thr 
1               5                   10                  15      


Asn Leu Asn Thr Val Thr Leu Lys Met Thr Ser Leu Thr Ala Ala Asp 
            20                  25                  30          


Thr Ala Thr Tyr Phe Cys 
        35              


<210>  38
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR1

<400>  38

Ala Glu Leu Asp Leu Thr Gln Thr Pro Ala Ser Val Glu Val Ala Ala 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Asn Cys Gln Val Ser 
            20                  25          


<210>  39
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR2

<400>  39

Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  40
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR3

<400>  40

Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Glu Phe Thr Leu Thr Ile Ser Gly Val Gln Cys Asp Asp Ala Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  41
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR4

<400>  41

Phe Gly Gly Gly Thr Glu Val Val Val Lys 
1               5                   10  


<210>  42
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR1

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = Phe, Ile, Leu, Met, Val, Trp or Tyr

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Xaa Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  43
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR3

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = Asp, Glu, His, Lys, Asn, Gln, Arg, Ser or Thr

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa = Phe, Ile, Leu, Met, Val, Trp or Tyr

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  Xaa = Phe, His, Ile, Leu, Met, Val, Trp or Tyr

<400>  43

Tyr Tyr Ser Asn Trp Ala Lys Ser Arg Phe Thr Ile Ser Arg Asp Xaa 
1               5                   10                  15      


Ser Lys Asn Thr Xaa Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Xaa Cys 
        35              


<210>  44
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR4

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = Pro, Gln or Arg

<400>  44

Trp Gly Xaa Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  45
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR1

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = Phe, Ile, Leu, Met, Val, Trp or Tyr

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = Phe or Ser

<400>  45

Asp Ile Gln Xaa Thr Gln Ser Pro Ser Xaa Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Val Ser 
            20                  25      


<210>  46
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR2

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = Ala, Gly, Pro or Ser

<400>  46

Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Xaa Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  47
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR3

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa = Asp, Glu, His, Lys, Asn, Gln, Arg, Ser or Thr

<400>  47

Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Xaa Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  48
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 Heavy chain constant region

<400>  48

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  49
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 Kappa Light chain constant region

<400>  49

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         