                         SEQUENCE LISTING

<110>  Takeda Vaccines Inc.
 
<120>  ZIKA VACCINES AND IMMUNOGENIC COMPOSITIONS, AND METHODS OF USING 
       THE SAME

<130>  T08289WO6

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  10675
<212>  DNA
<213>  Zika virus strain PRVABC59

<400>  1
gttgttgatc tgtgtgaatc agactgcgac agttcgagtt tgaagcgaaa gctagcaaca       60

gtatcaacag gttttatttt ggatttggaa acgagagttt ctggtcatga aaaacccaaa      120

aaagaaatcc ggaggattcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtgag      180

cccctttggg ggcttgaaga ggctgccagc cggacttctg ctgggtcatg ggcccatcag      240

gatggtcttg gcgattctag cctttttgag attcacggca atcaagccat cactgggtct      300

catcaataga tggggttcag tggggaaaaa agaggctatg gaaacaataa agaagttcaa      360

gaaagatctg gctgccatgc tgagaataat caatgctagg aaggagaaga agagacgagg      420

cgcagatact agtgtcggaa ttgttggcct cctgctgacc acagctatgg cagcggaggt      480

cactagacgt gggagtgcat actatatgta cttggacaga aacgatgctg gggaggccat      540

atcttttcca accacattgg ggatgaataa gtgttatata cagatcatgg atcttggaca      600

catgtgtgat gccaccatga gctatgaatg ccctatgctg gatgaggggg tggaaccaga      660

tgacgtcgat tgttggtgca acacgacgtc aacttgggtt gtgtacggaa cctgccatca      720

caaaaaaggt gaagcacgga gatctagaag agctgtgacg ctcccctccc attccaccag      780

gaagctgcaa acgcggtcgc aaacctggtt ggaatcaaga gaatacacaa agcacttgat      840

tagagtcgaa aattggatat tcaggaaccc tggcttcgcg ttagcagcag ctgccatcgc      900

ttggcttttg ggaagctcaa cgagccaaaa agtcatatac ttggtcatga tactgctgat      960

tgccccggca tacagcatca ggtgcatagg agtcagcaat agggactttg tggaaggtat     1020

gtcaggtggg acttgggttg atgttgtctt ggaacatgga ggttgtgtca ccgtaatggc     1080

acaggacaaa ccgactgtcg acatagagct ggttacaaca acagtcagca acatggcgga     1140

ggtaagatcc tactgctatg aggcatcaat atcagacatg gcttctgaca gccgctgccc     1200

aacacaaggt gaagcctacc ttgacaagca atcagacact caatatgtct gcaaaagaac     1260

gttagtggac agaggctggg gaaatggatg tggacttttt ggcaaaggga gcctggtgac     1320

atgcgctaag tttgcatgct ccaagaaaat gaccgggaag agcatccagc cagagaatct     1380

ggagtaccgg ataatgctgt cagttcatgg ctcccagcac agtgggatga tcgttaatga     1440

cacaggacat gaaactgatg agaatagagc gaaagttgag ataacgccca attcaccgag     1500

agccgaagcc accctggggg gttttggaag cctaggactt gattgtgaac cgaggacagg     1560

ccttgacttt tcagatttgt attacttgac tatgaataac aagcactggt tggttcacaa     1620

ggagtggttc cacgacattc cattaccttg gcacgctggg gcagacaccg gaactccaca     1680

ctggaacaac aaagaagcac tggtagagtt caaggacgca catgccaaaa ggcaaactgt     1740

cgtggttcta gggagtcaag aaggagcagt tcacacggcc cttgctggag ctctggaggc     1800

tgagatggat ggtgcaaagg gaaggctgtc ctctggccac ttgaaatgtc gcctgaaaat     1860

ggataaactt agattgaagg gcgtgtcata ctccttgtgt actgcagcgt tcacattcac     1920

caagatcccg gctgaaacac tgcacgggac agtcacagtg gaggtacagt acgcagggac     1980

agatggacct tgcaaggttc cagctcagat ggcggtggac atgcaaactc tgaccccagt     2040

tgggaggttg ataaccgcta accccgtaat cactgaaagc actgagaact ctaagatgat     2100

gctggaactt gatccaccat ttggggactc ttacattgtc ataggagtcg gggagaagaa     2160

gatcacccac cactggcaca ggagtggcag caccattgga aaagcatttg aagccactgt     2220

gagaggtgcc aagagaatgg cagtcttggg agacacagcc tgggactttg gatcagttgg     2280

aggcgctctc aactcattgg gcaagggcat ccatcaaatt tttggagcag ctttcaaatc     2340

attgtttgga ggaatgtcct ggttctcaca aattctcatt ggaacgttgc tgatgtggtt     2400

gggtctgaac acaaagaatg gatctatttc ccttatgtgc ttggccttag ggggagtgtt     2460

gatcttctta tccacagccg tctctgctga tgtggggtgc tcggtggact tctcaaagaa     2520

ggagacgaga tgcggtacag gggtgttcgt ctataacgac gttgaagcct ggagggacag     2580

gtacaagtac catcctgact ccccccgtag attggcagca gcagtcaagc aagcctggga     2640

agatggtatc tgcgggatct cctctgtttc aagaatggaa aacatcatgt ggagatcagt     2700

agaaggggag ctcaacgcaa tcctggaaga gaatggagtt caactgacgg tcgttgtggg     2760

atctgtaaaa aaccccatgt ggagaggtcc acagagattg cccgtgcctg tgaacgagct     2820

gccccacggc tggaaggctt gggggaaatc gtatttcgtc agagcagcaa agacaaataa     2880

cagctttgtc gtggatggtg acacactgaa ggaatgccca ctcaaacata gagcatggaa     2940

cagctttctt gtggaggatc atgggttcgg ggtatttcac actagtgtct ggctcaaggt     3000

tagagaagat tattcattag agtgtgatcc agccgttatt ggaacagctg ttaagggaaa     3060

ggaggctgta cacagtgatc taggctactg gattgagagt gagaagaatg acacatggag     3120

gctgaagagg gcccatctga tcgagatgaa aacatgtgaa tggccaaagt cccacacatt     3180

gtggacagat ggaatagaag agagtgatct gatcataccc aagtctttag ctgggccact     3240

cagccatcac aataccagag agggctacag gacccaaatg aaagggccat ggcacagtga     3300

agagcttgaa attcggtttg aggaatgccc aggcactaag gtccacgtgg aggaaacatg     3360

tggaacaaga ggaccatctc tgagatcaac cactgcaagc ggaagggtga tcgaggaatg     3420

gtgctgcagg gagtgcacaa tgcccccact gtcgttccgg gctaaagatg gctgttggta     3480

tggaatggag ataaggccca ggaaagaacc agaaagcaac ttagtaaggt caatggtgac     3540

tgcaggatca actgatcaca tggaccactt ctcccttgga gtgcttgtga tcctgctcat     3600

ggtgcaggaa gggctgaaga agagaatgac cacaaagatc atcataagca catcaatggc     3660

agtgctggta gctatgatcc tgggaggatt ttcaatgagt gacctggcta agcttgcaat     3720

tttgatgggt gccaccttcg cggaaatgaa cactggagga gatgtagctc atctggcgct     3780

gatagcggca ttcaaagtca gaccagcgtt gctggtatct ttcatcttca gagctaattg     3840

gacaccccgt gaaagcatgc tgctggcctt ggcctcgtgt cttttgcaaa ctgcgatctc     3900

cgccttggaa ggcgacctga tggttctcat caatggtttt gctttggcct ggttggcaat     3960

acgagcgatg gttgttccac gcactgataa catcaccttg gcaatcctgg ctgctctgac     4020

accactggcc cggggcacac tgcttgtggc gtggagagca ggccttgcta cttgcggggg     4080

gtttatgctc ctctctctga agggaaaagg cagtgtgaag aagaacttac catttgtcat     4140

ggccctggga ctaaccgctg tgaggctggt cgaccccatc aacgtggtgg gactgctgtt     4200

gctcacaagg agtgggaagc ggagctggcc ccctagcgaa gtactcacag ctgttggcct     4260

gatatgcgca ttggctggag ggttcgccaa ggcagatata gagatggctg ggcccatggc     4320

cgcggtcggt ctgctaattg tcagttacgt ggtctcagga aagagtgtgg acatgtacat     4380

tgaaagagca ggtgacatca catgggaaaa agatgcggaa gtcactggaa acagtccccg     4440

gctcgatgtg gcgctagatg agagtggtga tttctccctg gtggaggatg acggtccccc     4500

catgagagag atcatactca aggtggtcct gatgaccatc tgtggcatga acccaatagc     4560

catacccttt gcagctggag cgtggtacgt atacgtgaag actggaaaaa ggagtggtgc     4620

tctatgggat gtgcctgctc ccaaggaagt aaaaaagggg gagaccacag atggagtgta     4680

cagagtaatg actcgtagac tgctaggttc aacacaagtt ggagtgggag ttatgcaaga     4740

gggggtcttt cacactatgt ggcacgtcac aaaaggatcc gcgctgagaa gcggtgaagg     4800

gagacttgat ccatactggg gagatgtcaa gcaggatctg gtgtcatact gtggtccatg     4860

gaagctagat gccgcctggg atgggcacag cgaggtgcag ctcttggccg tgccccccgg     4920

agagagagcg aggaacatcc agactctgcc cggaatattt aagacaaagg atggggacat     4980

tggagcggtt gcgctggatt acccagcagg aacttcagga tctccaatcc tagacaagtg     5040

tgggagagtg ataggacttt atggcaatgg ggtcgtgatc aaaaacggga gttatgttag     5100

tgccatcacc caagggagga gggaggaaga gactcctgtt gagtgcttcg agccctcgat     5160

gctgaagaag aagcagctaa ctgtcttaga cttgcatcct ggagctggga aaaccaggag     5220

agttcttcct gaaatagtcc gtgaagccat aaaaacaaga ctccgtactg tgatcttagc     5280

tccaaccagg gttgtcgctg ctgaaatgga ggaggccctt agagggcttc cagtgcgtta     5340

tatgacaaca gcagtcaatg tcacccactc tggaacagaa atcgtcgact taatgtgcca     5400

tgccaccttc acttcacgtc tactacagcc aatcagagtc cccaactata atctgtatat     5460

tatggatgag gcccacttca cagatccctc aagtatagca gcaagaggat acatttcaac     5520

aagggttgag atgggcgagg cggctgccat cttcatgacc gccacgccac caggaacccg     5580

tgacgcattt ccggactcca actcaccaat tatggacacc gaagtggaag tcccagagag     5640

agcctggagc tcaggctttg attgggtgac ggatcattct ggaaaaacag tttggtttgt     5700

tccaagcgtg aggaacggca atgagatcgc agcttgtctg acaaaggctg gaaaacgggt     5760

catacagctc agcagaaaga cttttgagac agagttccag aaaacaaaac atcaagagtg     5820

ggactttgtc gtgacaactg acatttcaga gatgggcgcc aactttaaag ctgaccgtgt     5880

catagattcc aggagatgcc taaagccggt catacttgat ggcgagagag tcattctggc     5940

tggacccatg cctgtcacac atgccagcgc tgcccagagg agggggcgca taggcaggaa     6000

tcccaacaaa cctggagatg agtatctgta tggaggtggg tgcgcagaga ctgacgaaga     6060

ccatgcacac tggcttgaag caagaatgct ccttgacaat atttacctcc aagatggcct     6120

catagcctcg ctctatcgac ctgaggccga caaagtagca gccattgagg gagagttcaa     6180

gcttaggacg gagcaaagga agacctttgt ggaactcatg aaaagaggag atcttcctgt     6240

ttggctggcc tatcaggttg catctgccgg aataacctac acagatagaa gatggtgctt     6300

tgatggcacg accaacaaca ccataatgga agacagtgtg ccggcagagg tgtggaccag     6360

acacggagag aaaagagtgc tcaaaccgag gtggatggac gccagagttt gttcagatca     6420

tgcggccctg aagtcattca aggagtttgc cgctgggaaa agaggagcgg cttttggagt     6480

gatggaagcc ctgggaacac tgccaggaca catgacagag agattccagg aagccattga     6540

caacctcgct gtgctcatgc gggcagagac tggaagcagg ccttacaaag ccgcggcggc     6600

ccaattgccg gagaccctag agaccataat gcttttgggg ttgctgggaa cagtctcgct     6660

gggaatcttc ttcgtcttga tgaggaacaa gggcataggg aagatgggct ttggaatggt     6720

gactcttggg gccagcgcat ggctcatgtg gctctcggaa attgagccag ccagaattgc     6780

atgtgtcctc attgttgtgt tcctattgct ggtggtgctc atacctgagc cagaaaagca     6840

aagatctccc caggacaacc aaatggcaat catcatcatg gtagcagtag gtcttctggg     6900

cttgattacc gccaatgaac tcggatggtt ggagagaaca aagagtgacc taagccatct     6960

aatgggaagg agagaggagg gggcaaccat aggattctca atggacattg acctgcggcc     7020

agcctcagct tgggccatct atgctgcctt gacaactttc attaccccag ccgtccaaca     7080

tgcagtgacc acctcataca acaactactc cttaatggcg atggccacgc aagctggagt     7140

gttgtttggc atgggcaaag ggatgccatt ctacgcatgg gactttggag tcccgctgct     7200

aatgataggt tgctactcac aattaacacc cctgacccta atagtggcca tcattttgct     7260

cgtggcgcac tacatgtact tgatcccagg gctgcaggca gcagctgcgc gtgctgccca     7320

gaagagaacg gcagctggca tcatgaagaa ccctgttgtg gatggaatag tggtgactga     7380

cattgacaca atgacaattg acccccaagt ggagaaaaag atgggacagg tgctactcat     7440

agcagtagcc gtctccagcg ccatactgtc gcggaccgcc tgggggtggg gggaggctgg     7500

ggctctgatc acagccgcaa cttccacttt gtgggaaggc tctccgaaca agtactggaa     7560

ctcctctaca gccacttcac tgtgtaacat ttttagggga agttacttgg ctggagcttc     7620

tctaatctac acagtaacaa gaaacgctgg cttggtcaag agacgtgggg gtggaacagg     7680

agagaccctg ggagagaaat ggaaggcccg cttgaaccag atgtcggccc tggagttcta     7740

ctcctacaaa aagtcaggca tcaccgaggt gtgcagagaa gaggcccgcc gcgccctcaa     7800

ggacggtgtg gcaacgggag gccatgctgt gtcccgagga agtgcaaagc tgagatggtt     7860

ggtggagcgg ggatacctgc agccctatgg aaaggtcatt gatcttggat gtggcagagg     7920

gggctggagt tactacgtcg ccaccatccg caaagttcaa gaagtgaaag gatacacaaa     7980

aggaggccct ggtcatgaag aacccgtgtt ggtgcaaagc tatgggtgga acatagtccg     8040

tcttaagagt ggggtggacg tctttcatat ggcggctgag ccgtgtgaca cgttgctgtg     8100

tgacataggt gagtcatcat ctagtcctga agtggaagaa gcacggacgc tcagagtcct     8160

ctccatggtg ggggattggc ttgaaaaaag accaggagcc ttttgtataa aagtgttgtg     8220

cccatacacc agcactatga tggaaaccct ggagcgactg cagcgtaggt atgggggagg     8280

actggtcaga gtgccactct cccgcaactc tacacatgag atgtactggg tctctggagc     8340

gaaaagcaac accataaaaa gtgtgtccac cacgagccag ctcctcttgg ggcgcatgga     8400

cgggcctagg aggccagtga aatatgagga ggatgtgaat ctcggctctg gcacgcgggc     8460

tgtggtaagc tgcgctgaag ctcccaacat gaagatcatt ggtaaccgca ttgaaaggat     8520

ccgcagtgag cacgcggaaa cgtggttctt tgacgagaac cacccatata ggacatgggc     8580

ttaccatgga agctatgagg cccccacaca agggtcagcg tcctctctaa taaacggggt     8640

tgtcaggctc ctgtcaaaac cctgggatgt ggtgactgga gtcacaggaa tagccatgac     8700

cgacaccaca ccgtatggtc agcaaagagt tttcaaggaa aaagtggaca ctagggtgcc     8760

agacccccaa gaaggcactc gtcaggttat gagcatggtc tcttcctggt tgtggaaaga     8820

gctaggcaaa cacaaacggc cacgagtctg caccaaagaa gagttcatca acaaggttcg     8880

tagcaatgca gcattagggg caatatttga agaggaaaaa gagtggaaga ctgcagtgga     8940

agctgtgaac gatccaaggt tctgggctct agtggacaag gaaagagagc accacctgag     9000

aggagagtgc cagagctgtg tgtacaacat gatgggaaaa agagaaaaga aacaagggga     9060

atttggaaag gccaagggca gccgcgccat ctggtatatg tggctagggg ctagatttct     9120

agagttcgaa gcccttggat tcttgaacga ggatcactgg atggggagag agaactcagg     9180

aggtggtgtt gaagggctgg gattacaaag actcggatat gtcctagaag agatgagtcg     9240

tataccagga ggaaggatgt atgcagatga cactgctggc tgggacaccc gcattagcag     9300

gtttgatctg gagaatgaag ctctaatcac caaccaaatg gagaaagggc acagggcctt     9360

ggcattggcc ataatcaagt acacatacca aaacaaagtg gtaaaggtcc ttagaccagc     9420

tgaaaaaggg aaaacagtta tggacattat ttcgagacaa gaccaaaggg ggagcggaca     9480

agttgtcact tacgctctta acacatttac caacctagtg gtgcaactca ttcggaatat     9540

ggaggctgag gaagttctag agatgcaaga cttgtggctg ctgcggaggt cagagaaagt     9600

gaccaactgg ttgcagagca acggatggga taggctcaaa cgaatggcag tcagtggaga     9660

tgattgcgtt gtgaagccaa ttgatgatag gtttgcacat gccctcaggt tcttgaatga     9720

tatgggaaaa gttaggaagg acacacaaga gtggaaaccc tcaactggat gggacaactg     9780

ggaagaagtt ccgttttgct cccaccactt caacaagctc catctcaagg acgggaggtc     9840

cattgtggtt ccctgccgcc accaagatga actgattggc cgggcccgcg tctctccagg     9900

ggcgggatgg agcatccggg agactgcttg cctagcaaaa tcatatgcgc aaatgtggca     9960

gctcctttat ttccacagaa gggacctccg actgatggcc aatgccattt gttcatctgt    10020

gccagttgac tgggttccaa ctgggagaac tacctggtca atccatggaa agggagaatg    10080

gatgaccact gaagacatgc ttgtggtgtg gaacagagtg tggattgagg agaacgacca    10140

catggaagac aagaccccag ttacgaaatg gacagacatt ccctatttgg gaaaaaggga    10200

agacttgtgg tgtggatctc tcatagggca cagaccgcgc accacctggg ctgagaacat    10260

taaaaacaca gtcaacatgg tgcgcaggat cataggtgat gaagaaaagt acatggacta    10320

cctatccacc caagttcgct acttgggtga agaagggtct acacctggag tgctgtaagc    10380

accaatctta atgttgtcag gcctgctagt cagccacagc ttggggaaag ctgtgcagcc    10440

tgtgaccccc ccaggagaag ctgggaaacc aagcctatag tcaggccgag aacgccatgg    10500

cacggaagaa gccatgctgc ctgtgagccc ctcagaggac actgagtcaa aaaaccccac    10560

gcgcttggag gcgcaggatg ggaaaagaag gtggcgacct tccccaccct tcaatctggg    10620

gcctgaactg gagatcagct gtggatctcc agaagaggga ctagtggtta gagga         10675


<210>  2
<211>  3423
<212>  PRT
<213>  Zika virus strain PRVABC59

<400>  2

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Ser Pro Phe Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Thr 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Lys Lys Arg Arg Gly Ala Asp Thr Ser Val Gly Ile 
            100                 105                 110         


Val Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Val Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu Ala 
    130                 135                 140                 


Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Asp Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Arg Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Lys Glu Ala Val His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Lys Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Ile  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Met Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val His  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Ile  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Ala Met  Ile Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Ala Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Ile Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Ile  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Val Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Thr Leu Ala Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Leu Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Asp Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Thr Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ser Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


His Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Arg Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Thr Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Tyr Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys His Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Val Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Leu Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Asp  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Met Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Arg  His Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Ala Ala Phe Gly Val  Met Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Ser  Asp Leu Ser 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Ala Thr Ile  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Phe Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Phe  Gly Val Pro Leu Leu  Met Ile Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Val Ser  Ser Ala Ile Leu Ser  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro Tyr Gly  Lys Val Ile 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Val Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Lys Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Val Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Ala Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Leu  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Thr Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Val Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Asn  Arg Ile Glu Arg Ile  Arg Ser Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Phe  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Ile Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Val Met  Ser Met Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys His Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Lys 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys Gln Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Val Leu  Glu Glu Met Ser Arg  Ile Pro Gly 
    3035                 3040                 3045             


Gly Arg  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Arg  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Lys  Gly His Arg Ala Leu  Ala Leu Ala Ile Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Lys Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


Gln Asp  Leu Trp Leu Leu Arg  Arg Ser Glu Lys Val  Thr Asn Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Arg Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala His 
    3185                 3190                 3195             


Ala Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Asp Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu His Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ser Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Val 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Thr Lys Trp  Thr Asp Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Leu Trp Cys Gly  Ser Leu Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asn Thr Val Asn  Met Val Arg 
    3380                 3385                 3390             


Arg Ile  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  3
<211>  10807
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pre-MVS genomic sequence (P6e)

<400>  3
agttgttgat ctgtgtgaat cagactgcga cagttcgagt ttgaagcgaa agctagcaac       60

agtatcaaca ggttttattt tggatttgga aacgagagtt tctggtcatg aaaaacccaa      120

aaaagaaatc cggaggattc cggattgtca atatgctaaa acgcggagta gcccgtgtga      180

gcccctttgg gggcttgaag aggctgccag ccggacttct gctgggtcat gggcccatca      240

ggatggtctt ggcgattcta gcctttttga gattcacggc aatcaagcca tcactgggtc      300

tcatcaatag atggggttca gtggggaaaa aagaggctat ggaaacaata aagaagttca      360

agaaagatct ggctgccatg ctgagaataa tcaatgctag gaaggagaag aagagacgag      420

gcgcagatac tagtgtcgga attgttggcc tcctgctgac cacagctatg gcagcggagg      480

tcactagacg tgggagtgca tactatatgt acttggacag aaacgatgct ggggaggcca      540

tatcttttcc aaccacattg gggatgaata agtgttatat acagatcatg gatcttggac      600

acatgtgtga tgccaccatg agctatgaat gccctatgct ggatgagggg gtggaaccag      660

atgacgtcga ttgttggtgc aacacgacgt caacttgggt tgtgtacgga acctgccatc      720

acaaaaaagg tgaagcacgg agatctagaa gagctgtgac gctcccctcc cattccacca      780

ggaagctgca aacgcggtcg caaacctggt tggaatcaag agaatacaca aagcacttga      840

ttagagtcga aaattggata ttcaggaacc ctggcttcgc gttagcagca gctgccatcg      900

cttggctttt gggaagctca acgagccaaa aagtcatata cttggtcatg atactgctga      960

ttgccccggc atacagcatc aggtgcatag gagtcagcaa tagggacttt gtggaaggta     1020

tgtcaggtgg gacttgggtt gatgttgtct tggaacatgg aggttgtgtc accgtaatgg     1080

cacaggacaa accgactgtc gacatagagc tggttacaac aacagtcagc aacatggcgg     1140

aggtaagatc ctactgctat gaggcatcaa tatcagacat ggcttctgac agccgctgcc     1200

caacacaagg tgaagcctac cttgacaagc aatcagacac tcaatatgtc tgcaaaagaa     1260

cgttagtgga cagaggctgg ggaaatggat gtggactttt tggcaaaggg agcctggtga     1320

catgcgctaa gtttgcatgc tccaagaaaa tgaccgggaa gagcatccag ccagagaatc     1380

tggagtaccg gataatgctg tcagttcatg gctcccagca cagtgggatg atcgttaatg     1440

acacaggaca tgaaactgat gagaatagag cgaaagttga gataacgccc aattcaccga     1500

gagccgaagc caccctgggg ggttttggaa gcctaggact tgattgtgaa ccgaggacag     1560

gccttgactt ttcagatttg tattacttga ctatgaataa caagcactgg ttggttcaca     1620

aggagtggtt ccacgacatt ccattacctt ggcacgctgg ggcagacacc ggaactccac     1680

actggaacaa caaagaagca ctggtagagt tcaaggacgc acatgccaaa aggcaaactg     1740

tcgtggttct agggagtcaa gaaggagcag ttcacacggc ccttgctgga gctctggagg     1800

ctgagatgga tggtgcaaag ggaaggctgt cctctggcca cttgaaatgt cgcctgaaaa     1860

tggataaact tagattgaag ggcgtgtcat actccttgtg tactgcagcg ttcacattca     1920

ccaagatccc ggctgaaaca ctgcacggga cagtcacagt ggaggtacag tacgcaggga     1980

cagatggacc ttgcaaggtt ccagctcaga tggcggtgga catgcaaact ctgaccccag     2040

ttgggaggtt gataaccgct aaccccgtaa tcactgaaag cactgagaac tctaagatga     2100

tgctggaact tgatccacca tttggggact cttacattgt cataggagtc ggggagaaga     2160

agatcaccca ccactggcac aggagtggca gcaccattgg aaaagcattt gaagccactg     2220

tgagaggtgc caagagaatg gcagtcttgg gagacacagc ctgggacttt ggatcagttg     2280

gaggcgctct caactcattg ggcaagggca tccatcaaat ttttggagca gctttcaaat     2340

cattgtttgg aggaatgtcc tggttctcac aaattctcat tggaacgttg ctgatgtggt     2400

tgggtctgaa cacaaagaat ggatctattt cccttatgtg cttggcctta gggggagtgt     2460

tgatcttctt atccacagcc gtctctgctg atgtggggtg ctcggtggac ttctcaaaga     2520

aggagacgag atgcggtaca ggggtgttcg tctataacga cgttgaagcc tggagggaca     2580

ggtacaagta ccatcctgac tccccccgta gattggcagc agcagtcaag caagcctggg     2640

aagatggtat ctgcgggatc tcctctgttt caagaatgga aaacatcatg tggagatcag     2700

tagaagggga gctcaacgca atcctggaag agaatggagt tcaactgacg gtcgttgtgg     2760

gatctgtaaa aaaccccatg gggagaggtc cacagagatt gcccgtgcct gtgaacgagc     2820

tgccccacgg ctggaaggct tgggggaaat cgtatttcgt cagagcagca aagacaaata     2880

acagctttgt cgtggatggt gacacactga aggaatgccc actcaaacat agagcatgga     2940

acagctttct tgtggaggat catgggttcg gggtatttca cactagtgtc tggctcaagg     3000

ttagagaaga ttattcatta gagtgtgatc cagccgttat tggaacagct gttaagggaa     3060

aggaggctgt acacagtgat ctaggctact ggattgagag tgagaagaat gacacatgga     3120

ggctgaagag ggcccatctg atcgagatga aaacatgtga atggccaaag tcccacacat     3180

tgtggacaga tggaatagaa gagagtgatc tgatcatacc caagtcttta gctgggccac     3240

tcagccatca caataccaga gagggctaca ggacccaaat gaaagggcca tggcacagtg     3300

aagagcttga aattcggttt gaggaatgcc caggcactaa ggtccacgtg gaggaaacat     3360

gtggaacaag aggaccatct ctgagatcaa ccactgcaag cggaagggtg atcgaggaat     3420

ggtgctgcag ggagtgcaca atgcccccac tgtcgttccg ggctaaagat ggctgttggt     3480

atggaatgga gataaggccc aggaaagaac cagaaagcaa cttagtaagg tcaatggtga     3540

ctgcaggatc aactgatcac atggaccact tctcccttgg agtgcttgtg atcctgctca     3600

tggtgcagga agggctgaag aagagaatga ccacaaagat catcataagc acatcaatgg     3660

cagtgctggt agctatgatc ctgggaggat tttcaatgag tgacctggct aagcttgcaa     3720

ttttgatggg tgccaccttc gcggaaatga acactggagg agatgtagct catctggcgc     3780

tgatagcggc attcaaagtc agaccagcgt tgctggtatc tttcatcttc agagctaatt     3840

ggacaccccg tgaaagcatg ctgctggcct tggcctcgtg tcttttgcaa actgcgatct     3900

ccgccttgga aggcgacctg atggttctca tcaatggttt tgctttggcc tggttggcaa     3960

tacgagcgat ggttgttcca cgcactgata acatcacctt ggcaatcctg gctgctctga     4020

caccactggc ccggggcaca ctgcttgtgg cgtggagagc aggccttgct acttgcgggg     4080

ggtttatgct cctctctctg aagggaaaag gcagtgtgaa gaagaactta ccatttgtca     4140

tggccctggg actaaccgct gtgaggctgg tcgaccccat caacgtggtg ggactgctgt     4200

tgctcacaag gagtgggaag cggagctggc cccctagcga agtactcaca gctgttggcc     4260

tgatatgcgc attggctgga gggttcgcca aggcagatat agagatggct gggcccatgg     4320

ccgcggtcgg tctgctaatt gtcagttacg tggtctcagg aaagagtgtg gacatgtaca     4380

ttgaaagagc aggtgacatc acatgggaaa aagatgcgga agtcactgga aacagtcccc     4440

ggctcgatgt ggcgctagat gagagtggtg atttctccct ggtggaggat gacggtcccc     4500

ccatgagaga gatcatactc aaggtggtcc tgatgaccat ctgtggcatg aacccaatag     4560

ccataccctt tgcagctgga gcgtggtacg tatacgtgaa gactggaaaa aggagtggtg     4620

ctctatggga tgtgcctgct cccaaggaag taaaaaaggg ggagaccaca gatggagtgt     4680

acagagtaat gactcgtaga ctgctaggtt caacacaagt tggagtggga gttatgcaag     4740

agggggtctt tcacactatg tggcacgtca caaaaggatc cgcgctgaga agcggtgaag     4800

ggagacttga tccatactgg ggagatgtca agcaggatct ggtgtcatac tgtggtccat     4860

ggaagctaga tgccgcctgg gatgggcaca gcgaggtgca gctcttggcc gtgccccccg     4920

gagagagagc gaggaacatc cagactctgc ccggaatatt taagacaaag gatggggaca     4980

ttggagcggt tgcgctggat tacccagcag gaacttcagg atctccaatc ctagacaagt     5040

gtgggagagt gataggactt tatggcaatg gggtcgtgat caaaaacggg agttatgtta     5100

gtgccatcac ccaagggagg agggaggaag agactcctgt tgagtgcttc gagccctcga     5160

tgctgaagaa gaagcagcta actgtcttag acttgcatcc tggagctggg aaaaccagga     5220

gagttcttcc tgaaatagtc cgtgaagcca taaaaacaag actccgtact gtgatcttag     5280

ctccaaccag ggttgtcgct gctgaaatgg aggaggccct tagagggctt ccagtgcgtt     5340

atatgacaac agcagtcaat gtcacccact ctggaacaga aatcgtcgac ttaatgtgcc     5400

atgccacctt cacttcacgt ctactacagc caatcagagt ccccaactat aatctgtata     5460

ttatggatga ggcccacttc acagatccct caagtatagc agcaagagga tacatttcaa     5520

caagggttga gatgggcgag gcggctgcca tcttcatgac cgccacgcca ccaggaaccc     5580

gtgacgcatt tccggactcc aactcaccaa ttatggacac cgaagtggaa gtcccagaga     5640

gagcctggag ctcaggcttt gattgggtga cggatcattc tggaaaaaca gtttggtttg     5700

ttccaagcgt gaggaacggc aatgagatcg cagcttgtct gacaaaggct ggaaaacggg     5760

tcatacagct cagcagaaag acttttgaga cagagttcca gaaaacaaaa catcaagagt     5820

gggactttgt cgtgacaact gacatttcag agatgggcgc caactttaaa gctgaccgtg     5880

tcatagattc caggagatgc ctaaagccgg tcatacttga tggcgagaga gtcattctgg     5940

ctggacccat gcctgtcaca catgccagcg ctgcccagag gagggggcgc ataggcagga     6000

atcccaacaa acctggagat gagtatctgt atggaggtgg gtgcgcagag actgacgaag     6060

accatgcaca ctggcttgaa gcaagaatgc tccttgacaa tatttacctc caagatggcc     6120

tcatagcctc gctctatcga cctgaggccg acaaagtagc agccattgag ggagagttca     6180

agcttaggac ggagcaaagg aagacctttg tggaactcat gaaaagagga gatcttcctg     6240

tttggctggc ctatcaggtt gcatctgccg gaataaccta cacagataga agatggtgct     6300

ttgatggcac gaccaacaac accataatgg aagacagtgt gccggcagag gtgtggacca     6360

gacacggaga gaaaagagtg ctcaaaccga ggtggatgga cgccagagtt tgttcagatc     6420

atgcggccct gaagtcattc aaggagtttg ccgctgggaa aagaggagcg gcttttggag     6480

tgatggaagc cctgggaaca ctgccaggac acatgacaga gagattccag gaagccattg     6540

acaacctcgc tgtgctcatg cgggcagaga ctggaagcag gccttacaaa gccgcggcgg     6600

cccaattgcc ggagacccta gagaccataa tgcttttggg gttgctggga acagtctcgc     6660

tgggaatctt cttcgtcttg atgaggaaca agggcatagg gaagatgggc tttggaatgg     6720

tgactcttgg ggccagcgca tggctcatgt ggctctcgga aattgagcca gccagaattg     6780

catgtgtcct cattgttgtg ttcctattgc tggtggtgct catacctgag ccagaaaagc     6840

aaagatctcc ccaggacaac caaatggcaa tcatcatcat ggtagcagta ggtcttctgg     6900

gcttgattac cgccaatgaa ctcggatggt tggagagaac aaagagtgac ctaagccatc     6960

taatgggaag gagagaggag ggggcaacca taggattctc aatggacatt gacctgcggc     7020

cagcctcagc ttgggccatc tatgctgcct tgacaacttt cattacccca gccgtccaac     7080

atgcagtgac cacctcatac aacaactact ccttaatggc gatggccacg caagctggag     7140

tgttgtttgg catgggcaaa gggatgccat tctacgcatg ggactttgga gtcccgctgc     7200

taatgatagg ttgctactca caattaacac ccctgaccct aatagtggcc atcattttgc     7260

tcgtggcgca ctacatgtac ttgatcccag ggctgcaggc agcagctgcg cgtgctgccc     7320

agaagagaac ggcagctggc atcatgaaga accctgttgt ggatggaata gtggtgactg     7380

acattgacac aatgacaatt gacccccaag tggagaaaaa gatgggacag gtgctactca     7440

tagcagtagc cgtctccagc gccatactgt cgcggaccgc ctgggggtgg ggggaggctg     7500

gggctctgat cacagccgca acttccactt tgtgggaagg ctctccgaac aagtactgga     7560

actcctctac agccacttca ctgtgtaaca tttttagggg aagttacttg gctggagctt     7620

ctctaatcta cacagtaaca agaaacgctg gcttggtcaa gagacgtggg ggtggaacag     7680

gagagaccct gggagagaaa tggaaggccc gcttgaacca gatgtcggcc ctggagttct     7740

actcctacaa aaagtcaggc atcaccgagg tgtgcagaga agaggcccgc cgcgccctca     7800

aggacggtgt ggcaacggga ggccatgctg tgtcccgagg aagtgcaaag ctgagatggt     7860

tggtggagcg gggatacctg cagccctatg gaaaggtcat tgatcttgga tgtggcagag     7920

ggggctggag ttactacgtc gccaccatcc gcaaagttca agaagtgaaa ggatacacaa     7980

aaggaggccc tggtcatgaa gaacccgtgt tggtgcaaag ctatgggtgg aacatagtcc     8040

gtcttaagag tggggtggac gtctttcata tggcggctga gccgtgtgac acgttgctgt     8100

gtgacatagg tgagtcatca tctagtcctg aagtggaaga agcacggacg ctcagagtcc     8160

tctccatggt gggggattgg cttgaaaaaa gaccaggagc cttttgtata aaagtgttgt     8220

gcccatacac cagcactatg atggaaaccc tggagcgact gcagcgtagg tatgggggag     8280

gactggtcag agtgccactc tcccgcaact ctacacatga gatgtactgg gtctctggag     8340

cgaaaagcaa caccataaaa agtgtgtcca ccacgagcca gctcctcttg gggcgcatgg     8400

acgggcctag gaggccagtg aaatatgagg aggatgtgaa tctcggctct ggcacgcggg     8460

ctgtggtaag ctgcgctgaa gctcccaaca tgaagatcat tggtaaccgc attgaaagga     8520

tccgcagtga gcacgcggaa acgtggttct ttgacgagaa ccacccatat aggacatggg     8580

cttaccatgg aagctatgag gcccccacac aagggtcagc gtcctctcta ataaacgggg     8640

ttgtcaggct cctgtcaaaa ccctgggatg tggtgactgg agtcacagga atagccatga     8700

ccgacaccac accgtatggt cagcaaagag ttttcaagga aaaagtggac actagggtgc     8760

cagaccccca agaaggcact cgtcaggtta tgagcatggt ctcttcctgg ttgtggaaag     8820

agctaggcaa acacaaacgg ccacgagtct gcaccaaaga agagttcatc aacaaggttc     8880

gtagcaatgc agcattaggg gcaatatttg aagaggaaaa agagtggaag actgcagtgg     8940

aagctgtgaa cgatccaagg ttctgggctc tagtggacaa ggaaagagag caccacctga     9000

gaggagagtg ccagagctgt gtgtacaaca tgatgggaaa aagagaaaag aaacaagggg     9060

aatttggaaa ggccaagggc agccgcgcca tctggtatat gtggctaggg gctagatttc     9120

tagagttcga agcccttgga ttcttgaacg aggatcactg gatggggaga gagaactcag     9180

gaggtggtgt tgaagggctg ggattacaaa gactcggata tgtcctagaa gagatgagtc     9240

gtataccagg aggaaggatg tatgcagatg acactgctgg ctgggacacc cgcattagca     9300

ggtttgatct ggagaatgaa gctctaatca ccaaccaaat ggagaaaggg cacagggcct     9360

tggcattggc cataatcaag tacacatacc aaaacaaagt ggtaaaggtc cttagaccag     9420

ctgaaaaagg gaaaacagtt atggacatta tttcgagaca agaccaaagg gggagcggac     9480

aagttgtcac ttacgctctt aacacattta ccaacctagt ggtgcaactc attcggaata     9540

tggaggctga ggaagttcta gagatgcaag acttgtggct gctgcggagg tcagagaaag     9600

tgaccaactg gttgcagagc aacggatggg ataggctcaa acgaatggca gtcagtggag     9660

atgattgcgt tgtgaagcca attgatgata ggtttgcaca tgccctcagg ttcttgaatg     9720

atatgggaaa agttaggaag gacacacaag agtggaaacc ctcaactgga tgggacaact     9780

gggaagaagt tccgttttgc tcccaccact tcaacaagct ccatctcaag gacgggaggt     9840

ccattgtggt tccctgccgc caccaagatg aactgattgg ccgggcccgc gtctctccag     9900

gggcgggatg gagcatccgg gagactgctt gcctagcaaa atcatatgcg caaatgtggc     9960

agctccttta tttccacaga agggacctcc gactgatggc caatgccatt tgttcatctg    10020

tgccagttga ctgggttcca actgggagaa ctacctggtc aatccatgga aagggagaat    10080

ggatgaccac tgaagacatg cttgtggtgt ggaacagagt gtggattgag gagaacgacc    10140

acatggaaga caagacccca gttacgaaat ggacagacat tccctatttg ggaaaaaggg    10200

aagacttgtg gtgtggatct ctcatagggc acagaccgcg caccacctgg gctgagaaca    10260

ttaaaaacac agtcaacatg gtgcgcagga tcataggtga tgaagaaaag tacatggact    10320

acctatccac ccaagttcgc tacttgggtg aagaagggtc tacacctgga gtgctgtaag    10380

caccaatctt aatgttgtca ggcctgctag tcagccacag cttggggaaa gctgtgcagc    10440

ctgtgacccc cccaggagaa gctgggaaac caagcctata gtcaggccga gaacgccatg    10500

gcacggaaga agccatgctg cctgtgagcc cctcagagga cactgagtca aaaaacccca    10560

cgcgcttgga ggcgcaggat gggaaaagaa ggtggcgacc ttccccaccc ttcaatctgg    10620

ggcctgaact ggagatcagc tgtggatctc cagaagaggg actagtggtt agaggagacc    10680

ccccggaaaa cgcaaaacag catattgacg ctgggaaaga ccagagactc catgagtttc    10740

caccacgctg gccgccaggc acagatcgcc gaatagcggc ggccggtgtg gggaaatcca    10800

tgggtct                                                              10807


<210>  4
<211>  3423
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Zika Pre-MVS polyprotein sequence (P6e)

<400>  4

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Ser Pro Phe Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Thr 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Lys Lys Arg Arg Gly Ala Asp Thr Ser Val Gly Ile 
            100                 105                 110         


Val Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Val Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu Ala 
    130                 135                 140                 


Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Asp Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Arg Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Gly Arg Gly Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Lys Glu Ala Val His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Lys Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Ile  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Met Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val His  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Ile  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Ala Met  Ile Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Ala Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Ile Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Ile  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Val Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Thr Leu Ala Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Leu Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Asp Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Thr Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ser Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


His Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Arg Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Thr Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Tyr Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys His Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Val Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Leu Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Asp  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Met Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Arg  His Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Ala Ala Phe Gly Val  Met Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Ser  Asp Leu Ser 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Ala Thr Ile  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Phe Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Phe  Gly Val Pro Leu Leu  Met Ile Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Val Ser  Ser Ala Ile Leu Ser  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro Tyr Gly  Lys Val Ile 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Val Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Lys Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Val Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Ala Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Leu  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Thr Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Val Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Asn  Arg Ile Glu Arg Ile  Arg Ser Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Phe  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Ile Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Val Met  Ser Met Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys His Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Lys 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys Gln Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Val Leu  Glu Glu Met Ser Arg  Ile Pro Gly 
    3035                 3040                 3045             


Gly Arg  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Arg  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Lys  Gly His Arg Ala Leu  Ala Leu Ala Ile Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Lys Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


Gln Asp  Leu Trp Leu Leu Arg  Arg Ser Glu Lys Val  Thr Asn Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Arg Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala His 
    3185                 3190                 3195             


Ala Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Asp Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu His Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ser Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Val 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Thr Lys Trp  Thr Asp Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Leu Trp Cys Gly  Ser Leu Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asn Thr Val Asn  Met Val Arg 
    3380                 3385                 3390             


Arg Ile  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  5
<211>  10763
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Zika MVS genome sequence (P7e)

<400>  5
cagactgcga cagttcgagt ttgaagcgaa agctagcaac agtatcaaca ggttttattt       60

tggatttgga aacgagagtt tctggtcatg aaaaacccaa aaaagaaatc cggaggattc      120

cggattgtca atatgctaaa acgcggagta gcccgtgtga gcccctttgg gggcttgaag      180

aggctgccag ccggacttct gctgggtcat gggcccatca ggatggtctt ggcgattcta      240

gcctttttga gattcacggc aatcaagcca tcactgggtc tcatcaatag atggggttca      300

gtggggaaaa aagaggctat ggaaacaata aagaagttca agaaagatct ggctgccatg      360

ctgagaataa tcaatgctag gaaggagaag aagagacgag gcgcagatac tagtgtcgga      420

attgttggcc tcctgctgac cacagctatg gcagcggagg tcactagacg tgggagtgca      480

tactatatgt acttggacag aaacgatgct ggggaggcca tatcttttcc aaccacattg      540

gggatgaata agtgttatat acagatcatg gatcttggac acatgtgtga tgccaccatg      600

agctatgaat gccctatgct ggatgagggg gtggaaccag atgacgtcga ttgttggtgc      660

aacacgacgt caacttgggt tgtgtacgga acctgccatc acaaaaaagg tgaagcacgg      720

agatctagaa gagctgtgac gctcccctcc cattccacca ggaagctgca aacgcggtcg      780

caaacctggt tggaatcaag agaatacaca aagcacttga ttagagtcga aaattggata      840

ttcaggaacc ctggcttcgc gttagcagca gctgccatcg cttggctttt gggaagctca      900

acgagccaaa aagtcatata cttggtcatg atactgctga ttgccccggc atacagcatc      960

aggtgcatag gagtcagcaa tagggacttt gtggaaggta tgtcaggtgg gacttgggtt     1020

gatgttgtct tggaacatgg aggttgtgtc accgtaatgg cacaggacaa accgactgtc     1080

gacatagagc tggttacaac aacagtcagc aacatggcgg aggtaagatc ctactgctat     1140

gaggcatcaa tatcagacat ggcttctgac agccgctgcc caacacaagg tgaagcctac     1200

cttgacaagc aatcagacac tcaatatgtc tgcaaaagaa cgttagtgga cagaggctgg     1260

ggaaatggat gtggactttt tggcaaaggg agcctggtga catgcgctaa gtttgcatgc     1320

tccaagaaaa tgaccgggaa gagcatccag ccagagaatc tggagtaccg gataatgctg     1380

tcagttcatg gctcccagca cagtgggatg atcgttaatg acacaggaca tgaaactgat     1440

gagaatagag cgaaagttga gataacgccc aattcaccga gagccgaagc caccctgggg     1500

ggttttggaa gcctaggact tgattgtgaa ccgaggacag gccttgactt ttcagatttg     1560

tattacttga ctatgaataa caagcactgg ttggttcaca aggagtggtt ccacgacatt     1620

ccattacctt ggcacgctgg ggcagacacc ggaactccac actggaacaa caaagaagca     1680

ctggtagagt tcaaggacgc acatgccaaa aggcaaactg tcgtggttct agggagtcaa     1740

gaaggagcag ttcacacggc ccttgctgga gctctggagg ctgagatgga tggtgcaaag     1800

ggaaggctgt cctctggcca cttgaaatgt cgcctgaaaa tggataaact tagattgaag     1860

ggcgtgtcat actccttgtg tactgcagcg ttcacattca ccaagatccc ggctgaaaca     1920

ctgcacggga cagtcacagt ggaggtacag tacgcaggga cagatggacc ttgcaaggtt     1980

ccagctcaga tggcggtgga catgcaaact ctgaccccag ttgggaggtt gataaccgct     2040

aaccccgtaa tcactgaaag cactgagaac tctaagatga tgctggaact tgatccacca     2100

tttggggact cttacattgt cataggagtc ggggagaaga agatcaccca ccactggcac     2160

aggagtggca gcaccattgg aaaagcattt gaagccactg tgagaggtgc caagagaatg     2220

gcagtcttgg gagacacagc ctgggacttt ggatcagttg gaggcgctct caactcattg     2280

ggcaagggca tccatcaaat ttttggagca gctttcaaat cattgtttgg aggaatgtcc     2340

tggttctcac aaattctcat tggaacgttg ctgatgtggt tgggtctgaa cacaaagaat     2400

ggatctattt cccttatgtg cttggcctta gggggagtgt tgatcttctt atccacagcc     2460

gtctctgctg atgtggggtg ctcggtggac ttctcaaaga aggagacgag atgcggtaca     2520

ggggtgttcg tctataacga cgttgaagcc tggagggaca ggtacaagta ccatcctgac     2580

tccccccgta gattggcagc agcagtcaag caagcctggg aagatggtat ctgcgggatc     2640

tcctctgttt caagaatgga aaacatcatg tggagatcag tagaagggga gctcaacgca     2700

atcctggaag agaatggagt tcaactgacg gtcgttgtgg gatctgtaaa aaaccccatg     2760

gggagaggtc cacagagatt gcccgtgcct gtgaacgagc tgccccacgg ctggaaggct     2820

tgggggaaat cgtatttcgt cagagcagca aagacaaata acagctttgt cgtggatggt     2880

gacacactga aggaatgccc actcaaacat agagcatgga acagctttct tgtggaggat     2940

catgggttcg gggtatttca cactagtgtc tggctcaagg ttagagaaga ttattcatta     3000

gagtgtgatc cagccgttat tggaacagct gttaagggaa aggaggctgt acacagtgat     3060

ctaggctact ggattgagag tgagaagaat gacacatgga ggctgaagag ggcccatctg     3120

atcgagatga aaacatgtga atggccaaag tcccacacat tgtggacaga tggaatagaa     3180

gagagtgatc tgatcatacc caagtcttta gctgggccac tcagccatca caataccaga     3240

gagggctaca ggacccaaat gaaagggcca tggcacagtg aagagcttga aattcggttt     3300

gaggaatgcc caggcactaa ggtccacgtg gaggaaacat gtggaacaag aggaccatct     3360

ctgagatcaa ccactgcaag cggaagggtg atcgaggaat ggtgctgcag ggagtgcaca     3420

atgcccccac tgtcgttccg ggctaaagat ggctgttggt atggaatgga gataaggccc     3480

aggaaagaac cagaaagcaa cttagtaagg tcaatggtga ctgcaggatc aactgatcac     3540

atggaccact tctcccttgg agtgcttgtg atcctgctca tggtgcagga agggctgaag     3600

aagagaatga ccacaaagat catcataagc acatcaatgg cagtgctggt agctatgatc     3660

ctgggaggat tttcaatgag tgacctggct aagcttgcaa ttttgatggg tgccaccttc     3720

gcggaaatga acactggagg agatgtagct catctggcgc tgatagcggc attcaaagtc     3780

agaccagcgt tgctggtatc tttcatcttc agagctaatt ggacaccccg tgaaagcatg     3840

ctgctggcct tggcctcgtg tcttttgcaa actgcgatct ccgccttgga aggcgacctg     3900

atggttctca tcaatggttt tgctttggcc tggttggcaa tacgagcgat ggttgttcca     3960

cgcactgata acatcacctt ggcaatcctg gctgctctga caccactggc ccggggcaca     4020

ctgcttgtgg cgtggagagc aggccttgct acttgcgggg ggtttatgct cctctctctg     4080

aagggaaaag gcagtgtgaa gaagaactta ccatttgtca tggccctggg actaaccgct     4140

gtgaggctgg tcgaccccat caacgtggtg ggactgctgt tgctcacaag gagtgggaag     4200

cggagctggc cccctagcga agtactcaca gctgttggcc tgatatgcgc attggctgga     4260

gggttcgcca aggcagatat agagatggct gggcccatgg ccgcggtcgg tctgctaatt     4320

gtcagttacg tggtctcagg aaagagtgtg gacatgtaca ttgaaagagc aggtgacatc     4380

acatgggaaa aagatgcgga agtcactgga aacagtcccc ggctcgatgt ggcgctagat     4440

gagagtggtg atttctccct ggtggaggat gacggtcccc ccatgagaga gatcatactc     4500

aaggtggtcc tgatgaccat ctgtggcatg aacccaatag ccataccctt tgcagctgga     4560

gcgtggtacg tatacgtgaa gactggaaaa aggagtggtg ctctatggga tgtgcctgct     4620

cccaaggaag taaaaaaggg ggagaccaca gatggagtgt acagagtaat gactcgtaga     4680

ctgctaggtt caacacaagt tggagtggga gttatgcaag agggggtctt tcacactatg     4740

tggcacgtca caaaaggatc cgcgctgaga agcggtgaag ggagacttga tccatactgg     4800

ggagatgtca agcaggatct ggtgtcatac tgtggtccat ggaagctaga tgccgcctgg     4860

gatgggcaca gcgaggtgca gctcttggcc gtgccccccg gagagagagc gaggaacatc     4920

cagactctgc ccggaatatt taagacaaag gatggggaca ttggagcggt tgcgctggat     4980

tacccagcag gaacttcagg atctccaatc ctagacaagt gtgggagagt gataggactt     5040

tatggcaatg gggtcgtgat caaaaacggg agttatgtta gtgccatcac ccaagggagg     5100

agggaggaag agactcctgt tgagtgcttc gagccctcga tgctgaagaa gaagcagcta     5160

actgtcttag acttgcatcc tggagctggg aaaaccagga gagttcttcc tgaaatagtc     5220

cgtgaagcca taaaaacaag actccgtact gtgatcttag ctccaaccag ggttgtcgct     5280

gctgaaatgg aggaggccct tagagggctt ccagtgcgtt atatgacaac agcagtcaat     5340

gtcacccact ctggaacaga aatcgtcgac ttaatgtgcc atgccacctt cacttcacgt     5400

ctactacagc caatcagagt ccccaactat aatctgtata ttatggatga ggcccacttc     5460

acagatccct caagtatagc agcaagagga tacatttcaa caagggttga gatgggcgag     5520

gcggctgcca tcttcatgac cgccacgcca ccaggaaccc gtgacgcatt tccggactcc     5580

aactcaccaa ttatggacac cgaagtggaa gtcccagaga gagcctggag ctcaggcttt     5640

gattgggtga cggatcattc tggaaaaaca gtttggtttg ttccaagcgt gaggaacggc     5700

aatgagatcg cagcttgtct gacaaaggct ggaaaacggg tcatacagct cagcagaaag     5760

acttttgaga cagagttcca gaaaacaaaa catcaagagt gggactttgt cgtgacaact     5820

gacatttcag agatgggcgc caactttaaa gctgaccgtg tcatagattc caggagatgc     5880

ctaaagccgg tcatacttga tggcgagaga gtcattctgg ctggacccat gcctgtcaca     5940

catgccagcg ctgcccagag gagggggcgc ataggcagga atcccaacaa acctggagat     6000

gagtatctgt atggaggtgg gtgcgcagag actgacgaag accatgcaca ctggcttgaa     6060

gcaagaatgc tccttgacaa tatttacctc caagatggcc tcatagcctc gctctatcga     6120

cctgaggccg acaaagtagc agccattgag ggagagttca agcttaggac ggagcaaagg     6180

aagacctttg tggaactcat gaaaagagga gatcttcctg tttggctggc ctatcaggtt     6240

gcatctgccg gaataaccta cacagataga agatggtgct ttgatggcac gaccaacaac     6300

accataatgg aagacagtgt gccggcagag gtgtggacca gacacggaga gaaaagagtg     6360

ctcaaaccga ggtggatgga cgccagagtt tgttcagatc atgcggccct gaagtcattc     6420

aaggagtttg ccgctgggaa aagaggagcg gcttttggag tgatggaagc cctgggaaca     6480

ctgccaggac acatgacaga gagattccag gaagccattg acaacctcgc tgtgctcatg     6540

cgggcagaga ctggaagcag gccttacaaa gccgcggcgg cccaattgcc ggagacccta     6600

gagaccataa tgcttttggg gttgctggga acagtctcgc tgggaatctt cttcgtcttg     6660

atgaggaaca agggcatagg gaagatgggc tttggaatgg tgactcttgg ggccagcgca     6720

tggctcatgt ggctctcgga aattgagcca gccagaattg catgtgtcct cattgttgtg     6780

ttcctattgc tggtggtgct catacctgag ccagaaaagc aaagatctcc ccaggacaac     6840

caaatggcaa tcatcatcat ggtagcagta ggtcttctgg gcttgattac cgccaatgaa     6900

ctcggatggt tggagagaac aaagagtgac ctaagccatc taatgggaag gagagaggag     6960

ggggcaacca taggattctc aatggacatt gacctgcggc cagcctcagc ttgggccatc     7020

tatgctgcct tgacaacttt cattacccca gccgtccaac atgcagtgac cacctcatac     7080

aacaactact ccttaatggc gatggccacg caagctggag tgttgtttgg catgggcaaa     7140

gggatgccat tctacgcatg ggactttgga gtcccgctgc taatgatagg ttgctactca     7200

caattaacac ccctgaccct aatagtggcc atcattttgc tcgtggcgca ctacatgtac     7260

ttgatcccag ggctgcaggc agcagctgcg cgtgctgccc agaagagaac ggcagctggc     7320

atcatgaaga accctgttgt ggatggaata gtggtgactg acattgacac aatgacaatt     7380

gacccccaag tggagaaaaa gatgggacag gtgctactca tagcagtagc cgtctccagc     7440

gccatactgt cgcggaccgc ctgggggtgg ggggaggctg gggctctgat cacagccgca     7500

acttccactt tgtgggaagg ctctccgaac aagtactgga actcctctac agccacttca     7560

ctgtgtaaca tttttagggg aagttacttg gctggagctt ctctaatcta cacagtaaca     7620

agaaacgctg gcttggtcaa gagacgtggg ggtggaacag gagagaccct gggagagaaa     7680

tggaaggccc gcttgaacca gatgtcggcc ctggagttct actcctacaa aaagtcaggc     7740

atcaccgagg tgtgcagaga agaggcccgc cgcgccctca aggacggtgt ggcaacggga     7800

ggccatgctg tgtcccgagg aagtgcaaag ctgagatggt tggtggagcg gggatacctg     7860

cagccctatg gaaaggtcat tgatcttgga tgtggcagag ggggctggag ttactacgtc     7920

gccaccatcc gcaaagttca agaagtgaaa ggatacacaa aaggaggccc tggtcatgaa     7980

gaacccgtgt tggtgcaaag ctatgggtgg aacatagtcc gtcttaagag tggggtggac     8040

gtctttcata tggcggctga gccgtgtgac acgttgctgt gtgacatagg tgagtcatca     8100

tctagtcctg aagtggaaga agcacggacg ctcagagtcc tctccatggt gggggattgg     8160

cttgaaaaaa gaccaggagc cttttgtata aaagtgttgt gcccatacac cagcactatg     8220

atggaaaccc tggagcgact gcagcgtagg tatgggggag gactggtcag agtgccactc     8280

tcccgcaact ctacacatga gatgtactgg gtctctggag cgaaaagcaa caccataaaa     8340

agtgtgtcca ccacgagcca gctcctcttg gggcgcatgg acgggcctag gaggccagtg     8400

aaatatgagg aggatgtgaa tctcggctct ggcacgcggg ctgtggtaag ctgcgctgaa     8460

gctcccaaca tgaagatcat tggtaaccgc attgaaagga tccgcagtga gcacgcggaa     8520

acgtggttct ttgacgagaa ccacccatat aggacatggg cttaccatgg aagctatgag     8580

gcccccacac aagggtcagc gtcctctcta ataaacgggg ttgtcaggct cctgtcaaaa     8640

ccctgggatg tggtgactgg agtcacagga atagccatga ccgacaccac accgtatggt     8700

cagcaaagag ttttcaagga aaaagtggac actagggtgc cagaccccca agaaggcact     8760

cgtcaggtta tgagcatggt ctcttcctgg ttgtggaaag agctaggcaa acacaaacgg     8820

ccacgagtct gcaccaaaga agagttcatc aacaaggttc gtagcaatgc agcattaggg     8880

gcaatatttg aagaggaaaa agagtggaag actgcagtgg aagctgtgaa cgatccaagg     8940

ttctgggctc tagtggacaa ggaaagagag caccacctga gaggagagtg ccagagctgt     9000

gtgtacaaca tgatgggaaa aagagaaaag aaacaagggg aatttggaaa ggccaagggc     9060

agccgcgcca tctggtatat gtggctaggg gctagatttc tagagttcga agcccttgga     9120

ttcttgaacg aggatcactg gatggggaga gagaactcag gaggtggtgt tgaagggctg     9180

ggattacaaa gactcggata tgtcctagaa gagatgagtc gtataccagg aggaaggatg     9240

tatgcagatg acactgctgg ctgggacacc cgcattagca ggtttgatct ggagaatgaa     9300

gctctaatca ccaaccaaat ggagaaaggg cacagggcct tggcattggc cataatcaag     9360

tacacatacc aaaacaaagt ggtaaaggtc cttagaccag ctgaaaaagg gaaaacagtt     9420

atggacatta tttcgagaca agaccaaagg gggagcggac aagttgtcac ttacgctctt     9480

aacacattta ccaacctagt ggtgcaactc attcggaata tggaggctga ggaagttcta     9540

gagatgcaag acttgtggct gctgcggagg tcagagaaag tgaccaactg gttgcagagc     9600

aacggatggg ataggctcaa acgaatggca gtcagtggag atgattgcgt tgtgaagcca     9660

attgatgata ggtttgcaca tgccctcagg ttcttgaatg atatgggaaa agttaggaag     9720

gacacacaag agtggaaacc ctcaactgga tgggacaact gggaagaagt tccgttttgc     9780

tcccaccact tcaacaagct ccatctcaag gacgggaggt ccattgtggt tccctgccgc     9840

caccaagatg aactgattgg ccgggcccgc gtctctccag gggcgggatg gagcatccgg     9900

gagactgctt gcctagcaaa atcatatgcg caaatgtggc agctccttta tttccacaga     9960

agggacctcc gactgatggc caatgccatt tgttcatctg tgccagttga ctgggttcca    10020

actgggagaa ctacctggtc aatccatgga aagggagaat ggatgaccac tgaagacatg    10080

cttgtggtgt ggaacagagt gtggattgag gagaacgacc acatggaaga caagacccca    10140

gttacgaaat ggacagacat tccctatttg ggaaaaaggg aagacttgtg gtgtggatct    10200

ctcatagggc acagaccgcg caccacctgg gctgagaaca ttaaaaacac agtcaacatg    10260

gtgcgcagga tcataggtga tgaagaaaag tacatggact acctatccac ccaagttcgc    10320

tacttgggtg aagaagggtc tacacctgga gtgctgtaag caccaatctt aatgttgtca    10380

ggcctgctag tcagccacag cttggggaaa gctgtgcagc ctgtgacccc cccaggagaa    10440

gctgggaaac caagcctata gtcaggccga gaacgccatg gcacggaaga agccatgctg    10500

cctgtgagcc cctcagagga cactgagtca aaaaacccca cgcgcttgga ggcgcaggat    10560

gggaaaagaa ggtggcgacc ttccccaccc ttcaatctgg ggcctgaact ggagatcagc    10620

tgtggatctc cagaagaggg actagtggtt agaggagacc ccccggaaaa cgcaaaacag    10680

catattgacg ctgggaaaga ccagagactc catgagtttc caccacgctg gccgccaggc    10740

acagatcgcc gaatagcggc ggc                                            10763


<210>  6
<211>  504
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRVABC59, Pre-MVS, and MVS envelope (E) protein sequence

<400>  6

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  7
<211>  168
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRVABC59, Pre-MVS and MVS premembrane/membrane (prM/M) protein 
       sequence

<400>  7

Ala Glu Val Thr Arg Arg Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg 
1               5                   10                  15      


Asn Asp Ala Gly Glu Ala Ile Ser Phe Pro Thr Thr Leu Gly Met Asn 
            20                  25                  30          


Lys Cys Tyr Ile Gln Ile Met Asp Leu Gly His Met Cys Asp Ala Thr 
        35                  40                  45              


Met Ser Tyr Glu Cys Pro Met Leu Asp Glu Gly Val Glu Pro Asp Asp 
    50                  55                  60                  


Val Asp Cys Trp Cys Asn Thr Thr Ser Thr Trp Val Val Tyr Gly Thr 
65                  70                  75                  80  


Cys His His Lys Lys Gly Glu Ala Arg Arg Ser Arg Arg Ala Val Thr 
                85                  90                  95      


Leu Pro Ser His Ser Thr Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp 
            100                 105                 110         


Leu Glu Ser Arg Glu Tyr Thr Lys His Leu Ile Arg Val Glu Asn Trp 
        115                 120                 125             


Ile Phe Arg Asn Pro Gly Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp 
    130                 135                 140                 


Leu Leu Gly Ser Ser Thr Ser Gln Lys Val Ile Tyr Leu Val Met Ile 
145                 150                 155                 160 


Leu Leu Ile Ala Pro Ala Tyr Ser 
                165             


<210>  8
<211>  351
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Zika Pre-MVS and MVS NS1 protein sequence

<400>  8

Asp Val Gly Cys Ser Val Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly 
1               5                   10                  15      


Thr Gly Val Phe Val Tyr Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr 
            20                  25                  30          


Lys Tyr His Pro Asp Ser Pro Arg Arg Leu Ala Ala Ala Val Lys Gln 
        35                  40                  45              


Ala Trp Glu Asp Gly Ile Cys Gly Ile Ser Ser Val Ser Arg Met Glu 
    50                  55                  60                  


Asn Ile Met Trp Arg Ser Val Glu Gly Glu Leu Asn Ala Ile Leu Glu 
65                  70                  75                  80  


Glu Asn Gly Val Gln Leu Thr Val Val Val Gly Ser Val Lys Asn Pro 
                85                  90                  95      


Met Gly Arg Gly Pro Gln Arg Leu Pro Val Pro Val Asn Glu Leu Pro 
            100                 105                 110         


His Gly Trp Lys Ala Trp Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys 
        115                 120                 125             


Thr Asn Asn Ser Phe Val Val Asp Gly Asp Thr Leu Lys Glu Cys Pro 
    130                 135                 140                 


Leu Lys His Arg Ala Trp Asn Ser Phe Leu Val Glu Asp His Gly Phe 
145                 150                 155                 160 


Gly Val Phe His Thr Ser Val Trp Leu Lys Val Arg Glu Asp Tyr Ser 
                165                 170                 175     


Leu Glu Cys Asp Pro Ala Val Ile Gly Thr Ala Val Lys Gly Lys Glu 
            180                 185                 190         


Ala Val His Ser Asp Leu Gly Tyr Trp Ile Glu Ser Glu Lys Asn Asp 
        195                 200                 205             


Thr Trp Arg Leu Lys Arg Ala His Leu Ile Glu Met Lys Thr Cys Glu 
    210                 215                 220                 


Trp Pro Lys Ser His Thr Leu Trp Thr Asp Gly Ile Glu Glu Ser Asp 
225                 230                 235                 240 


Leu Ile Ile Pro Lys Ser Leu Ala Gly Pro Leu Ser His His Asn Thr 
                245                 250                 255     


Arg Glu Gly Tyr Arg Thr Gln Met Lys Gly Pro Trp His Ser Glu Glu 
            260                 265                 270         


Leu Glu Ile Arg Phe Glu Glu Cys Pro Gly Thr Lys Val His Val Glu 
        275                 280                 285             


Glu Thr Cys Gly Thr Arg Gly Pro Ser Leu Arg Ser Thr Thr Ala Ser 
    290                 295                 300                 


Gly Arg Val Ile Glu Glu Trp Cys Cys Arg Glu Cys Thr Met Pro Pro 
305                 310                 315                 320 


Leu Ser Phe Arg Ala Lys Asp Gly Cys Trp Tyr Gly Met Glu Ile Arg 
                325                 330                 335     


Pro Arg Lys Glu Pro Glu Ser Asn Leu Val Arg Ser Met Val Thr 
            340                 345                 350     


<210>  9
<211>  351
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Zika virus strain PRVABC59 NS1 protein sequence

<400>  9

Asp Val Gly Cys Ser Val Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly 
1               5                   10                  15      


Thr Gly Val Phe Val Tyr Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr 
            20                  25                  30          


Lys Tyr His Pro Asp Ser Pro Arg Arg Leu Ala Ala Ala Val Lys Gln 
        35                  40                  45              


Ala Trp Glu Asp Gly Ile Cys Gly Ile Ser Ser Val Ser Arg Met Glu 
    50                  55                  60                  


Asn Ile Met Trp Arg Ser Val Glu Gly Glu Leu Asn Ala Ile Leu Glu 
65                  70                  75                  80  


Glu Asn Gly Val Gln Leu Thr Val Val Val Gly Ser Val Lys Asn Pro 
                85                  90                  95      


Met Trp Arg Gly Pro Gln Arg Leu Pro Val Pro Val Asn Glu Leu Pro 
            100                 105                 110         


His Gly Trp Lys Ala Trp Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys 
        115                 120                 125             


Thr Asn Asn Ser Phe Val Val Asp Gly Asp Thr Leu Lys Glu Cys Pro 
    130                 135                 140                 


Leu Lys His Arg Ala Trp Asn Ser Phe Leu Val Glu Asp His Gly Phe 
145                 150                 155                 160 


Gly Val Phe His Thr Ser Val Trp Leu Lys Val Arg Glu Asp Tyr Ser 
                165                 170                 175     


Leu Glu Cys Asp Pro Ala Val Ile Gly Thr Ala Val Lys Gly Lys Glu 
            180                 185                 190         


Ala Val His Ser Asp Leu Gly Tyr Trp Ile Glu Ser Glu Lys Asn Asp 
        195                 200                 205             


Thr Trp Arg Leu Lys Arg Ala His Leu Ile Glu Met Lys Thr Cys Glu 
    210                 215                 220                 


Trp Pro Lys Ser His Thr Leu Trp Thr Asp Gly Ile Glu Glu Ser Asp 
225                 230                 235                 240 


Leu Ile Ile Pro Lys Ser Leu Ala Gly Pro Leu Ser His His Asn Thr 
                245                 250                 255     


Arg Glu Gly Tyr Arg Thr Gln Met Lys Gly Pro Trp His Ser Glu Glu 
            260                 265                 270         


Leu Glu Ile Arg Phe Glu Glu Cys Pro Gly Thr Lys Val His Val Glu 
        275                 280                 285             


Glu Thr Cys Gly Thr Arg Gly Pro Ser Leu Arg Ser Thr Thr Ala Ser 
    290                 295                 300                 


Gly Arg Val Ile Glu Glu Trp Cys Cys Arg Glu Cys Thr Met Pro Pro 
305                 310                 315                 320 


Leu Ser Phe Arg Ala Lys Asp Gly Cys Trp Tyr Gly Met Glu Ile Arg 
                325                 330                 335     


Pro Arg Lys Glu Pro Glu Ser Asn Leu Val Arg Ser Met Val Thr 
            340                 345                 350     


<210>  10
<211>  1053
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Zika Pre-MVS and MVS NS1 gene sequence

<400>  10
gatgtggggt gctcggtgga cttctcaaag aaggagacga gatgcggtac aggggtgttc       60

gtctataacg acgttgaagc ctggagggac aggtacaagt accatcctga ctccccccgt      120

agattggcag cagcagtcaa gcaagcctgg gaagatggta tctgcgggat ctcctctgtt      180

tcaagaatgg aaaacatcat gtggagatca gtagaagggg agctcaacgc aatcctggaa      240

gagaatggag ttcaactgac ggtcgttgtg ggatctgtaa aaaaccccat ggggagaggt      300

ccacagagat tgcccgtgcc tgtgaacgag ctgccccacg gctggaaggc ttgggggaaa      360

tcgtatttcg tcagagcagc aaagacaaat aacagctttg tcgtggatgg tgacacactg      420

aaggaatgcc cactcaaaca tagagcatgg aacagctttc ttgtggagga tcatgggttc      480

ggggtatttc acactagtgt ctggctcaag gttagagaag attattcatt agagtgtgat      540

ccagccgtta ttggaacagc tgttaaggga aaggaggctg tacacagtga tctaggctac      600

tggattgaga gtgagaagaa tgacacatgg aggctgaaga gggcccatct gatcgagatg      660

aaaacatgtg aatggccaaa gtcccacaca ttgtggacag atggaataga agagagtgat      720

ctgatcatac ccaagtcttt agctgggcca ctcagccatc acaataccag agagggctac      780

aggacccaaa tgaaagggcc atggcacagt gaagagcttg aaattcggtt tgaggaatgc      840

ccaggcacta aggtccacgt ggaggaaaca tgtggaacaa gaggaccatc tctgagatca      900

accactgcaa gcggaagggt gatcgaggaa tggtgctgca gggagtgcac aatgccccca      960

ctgtcgttcc gggctaaaga tggctgttgg tatggaatgg agataaggcc caggaaagaa     1020

ccagaaagca acttagtaag gtcaatggtg act                                  1053


<210>  11
<211>  1053
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Zika virus strain PRVABC59 NS1 gene sequence

<400>  11
gatgtggggt gctcggtgga cttctcaaag aaggagacga gatgcggtac aggggtgttc       60

gtctataacg acgttgaagc ctggagggac aggtacaagt accatcctga ctccccccgt      120

agattggcag cagcagtcaa gcaagcctgg gaagatggta tctgcgggat ctcctctgtt      180

tcaagaatgg aaaacatcat gtggagatca gtagaagggg agctcaacgc aatcctggaa      240

gagaatggag ttcaactgac ggtcgttgtg ggatctgtaa aaaaccccat gtggagaggt      300

ccacagagat tgcccgtgcc tgtgaacgag ctgccccacg gctggaaggc ttgggggaaa      360

tcgtatttcg tcagagcagc aaagacaaat aacagctttg tcgtggatgg tgacacactg      420

aaggaatgcc cactcaaaca tagagcatgg aacagctttc ttgtggagga tcatgggttc      480

ggggtatttc acactagtgt ctggctcaag gttagagaag attattcatt agagtgtgat      540

ccagccgtta ttggaacagc tgttaaggga aaggaggctg tacacagtga tctaggctac      600

tggattgaga gtgagaagaa tgacacatgg aggctgaaga gggcccatct gatcgagatg      660

aaaacatgtg aatggccaaa gtcccacaca ttgtggacag atggaataga agagagtgat      720

ctgatcatac ccaagtcttt agctgggcca ctcagccatc acaataccag agagggctac      780

aggacccaaa tgaaagggcc atggcacagt gaagagcttg aaattcggtt tgaggaatgc      840

ccaggcacta aggtccacgt ggaggaaaca tgtggaacaa gaggaccatc tctgagatca      900

accactgcaa gcggaagggt gatcgaggaa tggtgctgca gggagtgcac aatgccccca      960

ctgtcgttcc gggctaaaga tggctgttgg tatggaatgg agataaggcc caggaaagaa     1020

ccagaaagca acttagtaag gtcaatggtg act                                  1053


