                         б

<110>  ŵϺҽҩƼ޹˾

<120>  һֳЧؼӦ

<130>  0231-PA-005

<160>  12

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  SLN9056 HCDR1

<400>  1

Gly Asn Tyr Met Gly 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  SLN9056 HCDR2

<400>  2

Val Leu Tyr Thr Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  SLN9056 HCDR3

<400>  3

Ala Leu Gly Ser Ala Arg Trp Tyr Thr Ser Ser Leu Asp Ala Arg Ala 
1               5                   10                  15      


Tyr Asn Ile 
            


<210>  4
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  SLN9056 H-FR1

<400>  4

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Ala Tyr Gly 
            20                  25                  30  


<210>  5
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  SLN9056 H-FR2

<400>  5

Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val Ala 
1               5                   10                  


<210>  6
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  SLN9056 H-FR3

<400>  6

Arg Phe Thr Ile Ser Glu Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Leu 
            20                  25                  30          


<210>  7
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  SLN9056 H-FR4

<400>  7

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  8
<211>  128
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  SLN9056 VHH

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Ala Tyr Gly Gly Asn 
            20                  25                  30          


Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Val Leu Tyr Thr Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Glu Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Ala Leu Gly Ser Ala Arg Trp Tyr Thr Ser Ser Leu Asp Ala 
            100                 105                 110         


Arg Ala Tyr Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  9
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  

<400>  9

Gly Gly Gly Gly Ser Gly Gly Gly Ser Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  10
<211>  191
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  أhGH

<400>  10

Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg 
1               5                   10                  15      


Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu 
            20                  25                  30          


Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro 
        35                  40                  45              


Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg 
    50                  55                  60                  


Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu 
65                  70                  75                  80  


Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val 
                85                  90                  95      


Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp 
            100                 105                 110         


Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu 
        115                 120                 125             


Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser 
    130                 135                 140                 


Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr 
145                 150                 155                 160 


Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe 
                165                 170                 175     


Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe 
            180                 185                 190     


<210>  11
<211>  334
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  rhGH-VHHںϵ

<400>  11

Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg 
1               5                   10                  15      


Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu 
            20                  25                  30          


Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro 
        35                  40                  45              


Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg 
    50                  55                  60                  


Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu 
65                  70                  75                  80  


Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val 
                85                  90                  95      


Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp 
            100                 105                 110         


Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu 
        115                 120                 125             


Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser 
    130                 135                 140                 


Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr 
145                 150                 155                 160 


Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe 
                165                 170                 175     


Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe Gly 
            180                 185                 190         


Gly Gly Gly Ser Gly Gly Gly Ser Ser Gly Gly Gly Gly Ser Glu Val 
        195                 200                 205             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    210                 215                 220                 


Arg Leu Ser Cys Ala Ala Ser Gly His Ala Tyr Gly Gly Asn Tyr Met 
225                 230                 235                 240 


Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val Ala Val 
                245                 250                 255     


Leu Tyr Thr Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
            260                 265                 270         


Arg Phe Thr Ile Ser Glu Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln 
        275                 280                 285             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Leu 
    290                 295                 300                 


Ala Leu Gly Ser Ala Arg Trp Tyr Thr Ser Ser Leu Asp Ala Arg Ala 
305                 310                 315                 320 


Tyr Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                325                 330                 


<210>  12
<211>  129
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  SLN0066

<400>  12

His Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ile Gly His Gly Phe Asn 
            20                  25                  30          


Asn Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Gly Val Ala Ala Val Tyr Thr Gly Gly Gly Thr Pro Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Leu Ser Gln Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Gly Leu Asp Pro Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Ala Asp Ile Trp Arg Thr Tyr Arg Cys Gly Ala Gly Asp 
            100                 105                 110         


Thr Thr Val Phe Asp Tyr Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    
