                         SEQUENCE LISTING

<110>  NGM BIOPHARMACEUTICALS, INC.
 
<120>  USES OF ILT3 BINDING AGENTS

<130>  13370-156-228

<140>  PCT/US2022/025327
<141>  2022-04-19

<150>  US 63/301,013
<151>  2022-01-19

<160>  164   

<170>  PatentIn version 3.5

<210>  1
<211>  448
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human ILT3 amino acid sequence with predicted signal sequence

<400>  1

Met Ile Pro Thr Phe Thr Ala Leu Leu Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Met Gln Ala Gly Pro Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Ser Trp Gly Asn Ser Val Thr Ile Trp 
        35                  40                  45              


Cys Gln Gly Thr Leu Glu Ala Arg Glu Tyr Arg Leu Asp Lys Glu Glu 
    50                  55                  60                  


Ser Pro Ala Pro Trp Asp Arg Gln Asn Pro Leu Glu Pro Lys Asn Lys 
65                  70                  75                  80  


Ala Arg Phe Ser Ile Pro Ser Met Thr Glu Asp Tyr Ala Gly Arg Tyr 
                85                  90                  95      


Arg Cys Tyr Tyr Arg Ser Pro Val Gly Trp Ser Gln Pro Ser Asp Pro 
            100                 105                 110         


Leu Glu Leu Val Met Thr Gly Ala Tyr Ser Lys Pro Thr Leu Ser Ala 
        115                 120                 125             


Leu Pro Ser Pro Leu Val Thr Ser Gly Lys Ser Val Thr Leu Leu Cys 
    130                 135                 140                 


Gln Ser Arg Ser Pro Met Asp Thr Phe Leu Leu Ile Lys Glu Arg Ala 
145                 150                 155                 160 


Ala His Pro Leu Leu His Leu Arg Ser Glu His Gly Ala Gln Gln His 
                165                 170                 175     


Gln Ala Glu Phe Pro Met Ser Pro Val Thr Ser Val His Gly Gly Thr 
            180                 185                 190         


Tyr Arg Cys Phe Ser Ser His Gly Phe Ser His Tyr Leu Leu Ser His 
        195                 200                 205             


Pro Ser Asp Pro Leu Glu Leu Ile Val Ser Gly Ser Leu Glu Asp Pro 
    210                 215                 220                 


Arg Pro Ser Pro Thr Arg Ser Val Ser Thr Ala Ala Gly Pro Glu Asp 
225                 230                 235                 240 


Gln Pro Leu Met Pro Thr Gly Ser Val Pro His Ser Gly Leu Arg Arg 
                245                 250                 255     


His Trp Glu Val Leu Ile Gly Val Leu Val Val Ser Ile Leu Leu Leu 
            260                 265                 270         


Ser Leu Leu Leu Phe Leu Leu Leu Gln His Trp Arg Gln Gly Lys His 
        275                 280                 285             


Arg Thr Leu Ala Gln Arg Gln Ala Asp Phe Gln Arg Pro Pro Gly Ala 
    290                 295                 300                 


Ala Glu Pro Glu Pro Lys Asp Gly Gly Leu Gln Arg Arg Ser Ser Pro 
305                 310                 315                 320 


Ala Ala Asp Val Gln Gly Glu Asn Phe Cys Ala Ala Val Lys Asn Thr 
                325                 330                 335     


Gln Pro Glu Asp Gly Val Glu Met Asp Thr Arg Gln Ser Pro His Asp 
            340                 345                 350         


Glu Asp Pro Gln Ala Val Thr Tyr Ala Lys Val Lys His Ser Arg Pro 
        355                 360                 365             


Arg Arg Glu Met Ala Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu 
    370                 375                 380                 


Asp Thr Lys Asp Arg Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu 
385                 390                 395                 400 


Ala Ala Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His 
                405                 410                 415     


Ser Phe Thr Leu Arg Gln Lys Ala Thr Glu Pro Pro Pro Ser Gln Glu 
            420                 425                 430         


Gly Ala Ser Pro Ala Glu Pro Ser Val Tyr Ala Thr Leu Ala Ile His 
        435                 440                 445             


<210>  2
<211>  427
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human ILT3 amino acid sequence without predicted signal sequence

<400>  2

Gln Ala Gly Pro Leu Pro Lys Pro Thr Leu Trp Ala Glu Pro Gly Ser 
1               5                   10                  15      


Val Ile Ser Trp Gly Asn Ser Val Thr Ile Trp Cys Gln Gly Thr Leu 
            20                  25                  30          


Glu Ala Arg Glu Tyr Arg Leu Asp Lys Glu Glu Ser Pro Ala Pro Trp 
        35                  40                  45              


Asp Arg Gln Asn Pro Leu Glu Pro Lys Asn Lys Ala Arg Phe Ser Ile 
    50                  55                  60                  


Pro Ser Met Thr Glu Asp Tyr Ala Gly Arg Tyr Arg Cys Tyr Tyr Arg 
65                  70                  75                  80  


Ser Pro Val Gly Trp Ser Gln Pro Ser Asp Pro Leu Glu Leu Val Met 
                85                  90                  95      


Thr Gly Ala Tyr Ser Lys Pro Thr Leu Ser Ala Leu Pro Ser Pro Leu 
            100                 105                 110         


Val Thr Ser Gly Lys Ser Val Thr Leu Leu Cys Gln Ser Arg Ser Pro 
        115                 120                 125             


Met Asp Thr Phe Leu Leu Ile Lys Glu Arg Ala Ala His Pro Leu Leu 
    130                 135                 140                 


His Leu Arg Ser Glu His Gly Ala Gln Gln His Gln Ala Glu Phe Pro 
145                 150                 155                 160 


Met Ser Pro Val Thr Ser Val His Gly Gly Thr Tyr Arg Cys Phe Ser 
                165                 170                 175     


Ser His Gly Phe Ser His Tyr Leu Leu Ser His Pro Ser Asp Pro Leu 
            180                 185                 190         


Glu Leu Ile Val Ser Gly Ser Leu Glu Asp Pro Arg Pro Ser Pro Thr 
        195                 200                 205             


Arg Ser Val Ser Thr Ala Ala Gly Pro Glu Asp Gln Pro Leu Met Pro 
    210                 215                 220                 


Thr Gly Ser Val Pro His Ser Gly Leu Arg Arg His Trp Glu Val Leu 
225                 230                 235                 240 


Ile Gly Val Leu Val Val Ser Ile Leu Leu Leu Ser Leu Leu Leu Phe 
                245                 250                 255     


Leu Leu Leu Gln His Trp Arg Gln Gly Lys His Arg Thr Leu Ala Gln 
            260                 265                 270         


Arg Gln Ala Asp Phe Gln Arg Pro Pro Gly Ala Ala Glu Pro Glu Pro 
        275                 280                 285             


Lys Asp Gly Gly Leu Gln Arg Arg Ser Ser Pro Ala Ala Asp Val Gln 
    290                 295                 300                 


Gly Glu Asn Phe Cys Ala Ala Val Lys Asn Thr Gln Pro Glu Asp Gly 
305                 310                 315                 320 


Val Glu Met Asp Thr Arg Gln Ser Pro His Asp Glu Asp Pro Gln Ala 
                325                 330                 335     


Val Thr Tyr Ala Lys Val Lys His Ser Arg Pro Arg Arg Glu Met Ala 
            340                 345                 350         


Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg 
        355                 360                 365             


Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu 
    370                 375                 380                 


Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Phe Thr Leu Arg 
385                 390                 395                 400 


Gln Lys Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Ala Ser Pro Ala 
                405                 410                 415     


Glu Pro Ser Val Tyr Ala Thr Leu Ala Ile His 
            420                 425         


<210>  3
<211>  238
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human ILT3 Extracellular domain (aa 22-259)

<400>  3

Gln Ala Gly Pro Leu Pro Lys Pro Thr Leu Trp Ala Glu Pro Gly Ser 
1               5                   10                  15      


Val Ile Ser Trp Gly Asn Ser Val Thr Ile Trp Cys Gln Gly Thr Leu 
            20                  25                  30          


Glu Ala Arg Glu Tyr Arg Leu Asp Lys Glu Glu Ser Pro Ala Pro Trp 
        35                  40                  45              


Asp Arg Gln Asn Pro Leu Glu Pro Lys Asn Lys Ala Arg Phe Ser Ile 
    50                  55                  60                  


Pro Ser Met Thr Glu Asp Tyr Ala Gly Arg Tyr Arg Cys Tyr Tyr Arg 
65                  70                  75                  80  


Ser Pro Val Gly Trp Ser Gln Pro Ser Asp Pro Leu Glu Leu Val Met 
                85                  90                  95      


Thr Gly Ala Tyr Ser Lys Pro Thr Leu Ser Ala Leu Pro Ser Pro Leu 
            100                 105                 110         


Val Thr Ser Gly Lys Ser Val Thr Leu Leu Cys Gln Ser Arg Ser Pro 
        115                 120                 125             


Met Asp Thr Phe Leu Leu Ile Lys Glu Arg Ala Ala His Pro Leu Leu 
    130                 135                 140                 


His Leu Arg Ser Glu His Gly Ala Gln Gln His Gln Ala Glu Phe Pro 
145                 150                 155                 160 


Met Ser Pro Val Thr Ser Val His Gly Gly Thr Tyr Arg Cys Phe Ser 
                165                 170                 175     


Ser His Gly Phe Ser His Tyr Leu Leu Ser His Pro Ser Asp Pro Leu 
            180                 185                 190         


Glu Leu Ile Val Ser Gly Ser Leu Glu Asp Pro Arg Pro Ser Pro Thr 
        195                 200                 205             


Arg Ser Val Ser Thr Ala Ala Gly Pro Glu Asp Gln Pro Leu Met Pro 
    210                 215                 220                 


Thr Gly Ser Val Pro His Ser Gly Leu Arg Arg His Trp Glu 
225                 230                 235             


<210>  4
<211>  92
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human ILT3 Ig-like C2-type Domain 1 amino acid sequence without 
       N-terminal domain (aa 27-118)

<400>  4

Pro Lys Pro Thr Leu Trp Ala Glu Pro Gly Ser Val Ile Ser Trp Gly 
1               5                   10                  15      


Asn Ser Val Thr Ile Trp Cys Gln Gly Thr Leu Glu Ala Arg Glu Tyr 
            20                  25                  30          


Arg Leu Asp Lys Glu Glu Ser Pro Ala Pro Trp Asp Arg Gln Asn Pro 
        35                  40                  45              


Leu Glu Pro Lys Asn Lys Ala Arg Phe Ser Ile Pro Ser Met Thr Glu 
    50                  55                  60                  


Asp Tyr Ala Gly Arg Tyr Arg Cys Tyr Tyr Arg Ser Pro Val Gly Trp 
65                  70                  75                  80  


Ser Gln Pro Ser Asp Pro Leu Glu Leu Val Met Thr 
                85                  90          


<210>  5
<211>  95
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human ILT3 Ig-like C2-type Domain 2 amino acid sequence (aa 
       124-218)

<400>  5

Pro Thr Leu Ser Ala Leu Pro Ser Pro Leu Val Thr Ser Gly Lys Ser 
1               5                   10                  15      


Val Thr Leu Leu Cys Gln Ser Arg Ser Pro Met Asp Thr Phe Leu Leu 
            20                  25                  30          


Ile Lys Glu Arg Ala Ala His Pro Leu Leu His Leu Arg Ser Glu His 
        35                  40                  45              


Gly Ala Gln Gln His Gln Ala Glu Phe Pro Met Ser Pro Val Thr Ser 
    50                  55                  60                  


Val His Gly Gly Thr Tyr Arg Cys Phe Ser Ser His Gly Phe Ser His 
65                  70                  75                  80  


Tyr Leu Leu Ser His Pro Ser Asp Pro Leu Glu Leu Ile Val Ser 
                85                  90                  95  


<210>  6
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyno ILT3 amino acid sequence with predicted signal sequence

<400>  6

Met Thr Pro Pro Leu Thr Val Leu Phe Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr Cys Val Gln Ala Gly Pro Leu Pro Lys Pro Thr Val Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Ser Trp Gly Ser Pro Val Thr Ile Trp 
        35                  40                  45              


Cys Gln Gly Thr Leu Asp Ala Gln Glu Tyr His Leu Asp Lys Glu Gly 
    50                  55                  60                  


Ser Pro Ala Pro Trp Asp Thr Gln Asn Pro Leu Glu Pro Arg Asn Lys 
65                  70                  75                  80  


Ala Lys Phe Ser Ile Pro Ser Met Thr Gln His Tyr Ala Gly Arg Tyr 
                85                  90                  95      


Arg Cys Tyr Tyr His Ser His Pro Asp Trp Ser Glu Asp Ser Asp Pro 
            100                 105                 110         


Leu Asp Leu Val Met Thr Gly Ala Tyr Ser Lys Pro Ile Leu Ser Val 
        115                 120                 125             


Leu Pro Ser Pro Leu Val Thr Ser Gly Glu Ser Val Thr Leu Leu Cys 
    130                 135                 140                 


Gln Ser Gln Ser Pro Met Asp Thr Phe Leu Leu Phe Lys Glu Gly Ala 
145                 150                 155                 160 


Ala His Pro Leu Pro Arg Leu Arg Ser Gln His Gly Ala Gln Leu His 
                165                 170                 175     


Trp Ala Glu Phe Pro Met Gly Pro Val Thr Ser Val His Gly Gly Thr 
            180                 185                 190         


Tyr Arg Cys Ile Ser Ser Arg Ser Phe Ser His Tyr Leu Leu Ser Arg 
        195                 200                 205             


Pro Ser Asp Pro Val Glu Leu Thr Val Leu Gly Ser Leu Glu Ser Pro 
    210                 215                 220                 


Ser Pro Ser Pro Thr Arg Ser Ile Ser Ala Ala Ala Gly Pro Glu Asp 
225                 230                 235                 240 


Gln Ser Leu Met Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Arg Arg 
                245                 250                 255     


His Trp Glu Val Leu Ile Gly Val Leu Val Val Ser Ile Leu Leu Leu 
            260                 265                 270         


Ser Leu Val Phe Phe Leu Leu Leu Gln His Trp Arg Gln Gly Lys His 
        275                 280                 285             


Arg Thr Ser Ala Gln Arg Gln Ala Asp Phe Gln Arg Pro Pro Gly Ala 
    290                 295                 300                 


Ala Glu Pro Glu Pro Lys Asp Gly Gly Leu Gln Arg Arg Ser Arg Pro 
305                 310                 315                 320 


Ala Ala Asp Val Gln Gly Glu Asn Pro Asn Ala Ala Met Lys Asp Thr 
                325                 330                 335     


Gln Pro Glu Asp Gly Val Glu Leu Asp Ser Arg Gln Arg Pro His Asp 
            340                 345                 350         


Glu Asp Pro Gln Ala Val Thr Tyr Ala Arg Val Lys His Ser Gly Pro 
        355                 360                 365             


Arg Arg Glu Met Ala Ser Pro Pro Ser Pro Leu Ser Glu Glu Phe Leu 
    370                 375                 380                 


Asp Thr Lys Asp Thr Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Gln 
385                 390                 395                 400 


Ala Ala Thr Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu Gln 
                405                 410                 415     


Ser Leu Thr Leu Arg Arg Glu Ala Thr Glu Pro Pro Pro Pro Gln Lys 
            420                 425                 430         


Arg Glu Pro Ser Ala Glu Pro Ser Val Tyr Ala Thr Leu Ala Ile His 
        435                 440                 445             


<210>  7
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyno ILT3 amino acid sequence without predicted signal sequence

<400>  7

Gln Ala Gly Pro Leu Pro Lys Pro Thr Val Trp Ala Glu Pro Gly Ser 
1               5                   10                  15      


Val Ile Ser Trp Gly Ser Pro Val Thr Ile Trp Cys Gln Gly Thr Leu 
            20                  25                  30          


Asp Ala Gln Glu Tyr His Leu Asp Lys Glu Gly Ser Pro Ala Pro Trp 
        35                  40                  45              


Asp Thr Gln Asn Pro Leu Glu Pro Arg Asn Lys Ala Lys Phe Ser Ile 
    50                  55                  60                  


Pro Ser Met Thr Gln His Tyr Ala Gly Arg Tyr Arg Cys Tyr Tyr His 
65                  70                  75                  80  


Ser His Pro Asp Trp Ser Glu Asp Ser Asp Pro Leu Asp Leu Val Met 
                85                  90                  95      


Thr Gly Ala Tyr Ser Lys Pro Ile Leu Ser Val Leu Pro Ser Pro Leu 
            100                 105                 110         


Val Thr Ser Gly Glu Ser Val Thr Leu Leu Cys Gln Ser Gln Ser Pro 
        115                 120                 125             


Met Asp Thr Phe Leu Leu Phe Lys Glu Gly Ala Ala His Pro Leu Pro 
    130                 135                 140                 


Arg Leu Arg Ser Gln His Gly Ala Gln Leu His Trp Ala Glu Phe Pro 
145                 150                 155                 160 


Met Gly Pro Val Thr Ser Val His Gly Gly Thr Tyr Arg Cys Ile Ser 
                165                 170                 175     


Ser Arg Ser Phe Ser His Tyr Leu Leu Ser Arg Pro Ser Asp Pro Val 
            180                 185                 190         


Glu Leu Thr Val Leu Gly Ser Leu Glu Ser Pro Ser Pro Ser Pro Thr 
        195                 200                 205             


Arg Ser Ile Ser Ala Ala Ala Gly Pro Glu Asp Gln Ser Leu Met Pro 
    210                 215                 220                 


Thr Gly Ser Asp Pro Gln Ser Gly Leu Arg Arg His Trp Glu Val Leu 
225                 230                 235                 240 


Ile Gly Val Leu Val Val Ser Ile Leu Leu Leu Ser Leu Val Phe Phe 
                245                 250                 255     


Leu Leu Leu Gln His Trp Arg Gln Gly Lys His Arg Thr Ser Ala Gln 
            260                 265                 270         


Arg Gln Ala Asp Phe Gln Arg Pro Pro Gly Ala Ala Glu Pro Glu Pro 
        275                 280                 285             


Lys Asp Gly Gly Leu Gln Arg Arg Ser Arg Pro Ala Ala Asp Val Gln 
    290                 295                 300                 


Gly Glu Asn Pro Asn Ala Ala Met Lys Asp Thr Gln Pro Glu Asp Gly 
305                 310                 315                 320 


Val Glu Leu Asp Ser Arg Gln Arg Pro His Asp Glu Asp Pro Gln Ala 
                325                 330                 335     


Val Thr Tyr Ala Arg Val Lys His Ser Gly Pro Arg Arg Glu Met Ala 
            340                 345                 350         


Ser Pro Pro Ser Pro Leu Ser Glu Glu Phe Leu Asp Thr Lys Asp Thr 
        355                 360                 365             


Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Gln Ala Ala Thr Ser Glu 
    370                 375                 380                 


Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu Gln Ser Leu Thr Leu Arg 
385                 390                 395                 400 


Arg Glu Ala Thr Glu Pro Pro Pro Pro Gln Lys Arg Glu Pro Ser Ala 
                405                 410                 415     


Glu Pro Ser Val Tyr Ala Thr Leu Ala Ile His 
            420                 425         


<210>  8
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyno ILT3 Extracellular domain (aa 22-259)

<400>  8

Gln Ala Gly Pro Leu Pro Lys Pro Thr Val Trp Ala Glu Pro Gly Ser 
1               5                   10                  15      


Val Ile Ser Trp Gly Ser Pro Val Thr Ile Trp Cys Gln Gly Thr Leu 
            20                  25                  30          


Asp Ala Gln Glu Tyr His Leu Asp Lys Glu Gly Ser Pro Ala Pro Trp 
        35                  40                  45              


Asp Thr Gln Asn Pro Leu Glu Pro Arg Asn Lys Ala Lys Phe Ser Ile 
    50                  55                  60                  


Pro Ser Met Thr Gln His Tyr Ala Gly Arg Tyr Arg Cys Tyr Tyr His 
65                  70                  75                  80  


Ser His Pro Asp Trp Ser Glu Asp Ser Asp Pro Leu Asp Leu Val Met 
                85                  90                  95      


Thr Gly Ala Tyr Ser Lys Pro Ile Leu Ser Val Leu Pro Ser Pro Leu 
            100                 105                 110         


Val Thr Ser Gly Glu Ser Val Thr Leu Leu Cys Gln Ser Gln Ser Pro 
        115                 120                 125             


Met Asp Thr Phe Leu Leu Phe Lys Glu Gly Ala Ala His Pro Leu Pro 
    130                 135                 140                 


Arg Leu Arg Ser Gln His Gly Ala Gln Leu His Trp Ala Glu Phe Pro 
145                 150                 155                 160 


Met Gly Pro Val Thr Ser Val His Gly Gly Thr Tyr Arg Cys Ile Ser 
                165                 170                 175     


Ser Arg Ser Phe Ser His Tyr Leu Leu Ser Arg Pro Ser Asp Pro Val 
            180                 185                 190         


Glu Leu Thr Val Leu Gly Ser Leu Glu Ser Pro Ser Pro Ser Pro Thr 
        195                 200                 205             


Arg Ser Ile Ser Ala Ala Ala Gly Pro Glu Asp Gln Ser Leu Met Pro 
    210                 215                 220                 


Thr Gly Ser Asp Pro Gln Ser Gly Leu Arg Arg His Trp Glu 
225                 230                 235             


<210>  9
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyno ILT3 Ig-like C2-type Domain 1 amino acid sequence without 
       N-terminal domain (aa 27-118)

<400>  9

Pro Lys Pro Thr Val Trp Ala Glu Pro Gly Ser Val Ile Ser Trp Gly 
1               5                   10                  15      


Ser Pro Val Thr Ile Trp Cys Gln Gly Thr Leu Asp Ala Gln Glu Tyr 
            20                  25                  30          


His Leu Asp Lys Glu Gly Ser Pro Ala Pro Trp Asp Thr Gln Asn Pro 
        35                  40                  45              


Leu Glu Pro Arg Asn Lys Ala Lys Phe Ser Ile Pro Ser Met Thr Gln 
    50                  55                  60                  


His Tyr Ala Gly Arg Tyr Arg Cys Tyr Tyr His Ser His Pro Asp Trp 
65                  70                  75                  80  


Ser Glu Asp Ser Asp Pro Leu Asp Leu Val Met Thr 
                85                  90          


<210>  10
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyno ILT3 Ig-like C2-type Domain 2 amino acid sequence without 
       N-terminal domain (aa 124-218)

<400>  10

Pro Ile Leu Ser Val Leu Pro Ser Pro Leu Val Thr Ser Gly Glu Ser 
1               5                   10                  15      


Val Thr Leu Leu Cys Gln Ser Gln Ser Pro Met Asp Thr Phe Leu Leu 
            20                  25                  30          


Phe Lys Glu Gly Ala Ala His Pro Leu Pro Arg Leu Arg Ser Gln His 
        35                  40                  45              


Gly Ala Gln Leu His Trp Ala Glu Phe Pro Met Gly Pro Val Thr Ser 
    50                  55                  60                  


Val His Gly Gly Thr Tyr Arg Cys Ile Ser Ser Arg Ser Phe Ser His 
65                  70                  75                  80  


Tyr Leu Leu Ser Arg Pro Ser Asp Pro Val Glu Leu Thr Val Leu 
                85                  90                  95  


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 3A3 VH CDR1 (Exemplary, AbM)

<400>  11

Gly Phe Ser Leu Thr Ser Tyr Gly Val His 
1               5                   10  


<210>  12
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 3A3 VH CDR2 (Exemplary, Kabat)

<400>  12

Val Ile Trp Pro Gly Gly Thr Ile Asn Tyr Asn Ser Ala Leu Met Ser 
1               5                   10                  15      


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 3A3 VH CDR3 (Exemplary, Chothia, AbM, Kabat)

<400>  13

Asp Lys Tyr Asp Gly Gly Trp Phe Ala Tyr 
1               5                   10  


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 3A3 VL CDR1 (Exemplary, Chothia, AbM, Kabat)

<400>  14

Lys Ala Ser Gln Asn Val Arg Thr Ala Val Ala 
1               5                   10      


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 3A3 VL CDR2 (Exemplary, Chothia, AbM, Kabat)

<400>  15

Leu Ala Ser Asn Arg His Thr 
1               5           


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 3A3 VL CDR3 (Exemplary, Chothia, AbM, Kabat)

<400>  16

Leu Gln His Leu Asn Tyr Pro Leu Thr 
1               5                   


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 3A3 VH CDR1 (Chothia)

<400>  17

Gly Phe Ser Leu Thr Ser Tyr 
1               5           


<210>  18
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 3A3 VH CDR2 (Chothia)

<400>  18

Trp Pro Gly Gly Thr 
1               5   


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 3A3 VH CDR2 (AbM)

<400>  19

Val Ile Trp Pro Gly Gly Thr Ile Asn 
1               5                   


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 3A3 VH CDR1 (Kabat)

<400>  20

Ser Tyr Gly Val His 
1               5   


<210>  21
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 3A3 VH CDR1 (Contact)

<400>  21

Thr Ser Tyr Gly Val His 
1               5       


<210>  22
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 3A3 VH CDR2 (Contact)

<400>  22

Trp Leu Gly Val Ile Trp Pro Gly Gly Thr Ile Asn 
1               5                   10          


<210>  23
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 3A3 VH CDR3 (Contact)

<400>  23

Ala Ser Asp Lys Tyr Asp Gly Gly Trp Phe Ala 
1               5                   10      


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 3A3 VL CDR1 (Contact)

<400>  24

Arg Thr Ala Val Ala Trp Tyr 
1               5           


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 3A3 VL CDR2 (Contact)

<400>  25

Ala Leu Ile Tyr Leu Ala Ser Asn Arg His 
1               5                   10  


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 3A3 VL CDR3 (Contact)

<400>  26

Leu Gln His Leu Asn Tyr Pro Leu 
1               5               


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 5A7, 48A6, Hz5A7.v5 VH CDR1 (Exemplary, AbM)

<400>  27

Gly Phe Thr Phe Ser Ser Tyr Gly Met Ser 
1               5                   10  


<210>  28
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 5A7, Hz5A7.v5 VH CDR2 (Exemplary, Kabat)

<400>  28

Thr Ile Ser Gly Gly Gly Ser Tyr Thr Asn Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  29
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 5A7 VH CDR3 (Exemplary, Chothia, AbM, Kabat)

<400>  29

Arg Glu Trp Arg Met Thr Leu Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  30
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 5A7 VL CDR1 (Exemplary, Chothia, AbM, Kabat)

<400>  30

Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe Met His 
1               5                   10                  15  


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 5A7, Hz5A7.v5 VL CDR2 (Exemplary, Chothia, AbM, Kabat)

<400>  31

Leu Thr Ser Asn Leu Glu Ser 
1               5           


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 5A7, Hz5A7.v5 VL CDR3 (Exemplary, Chothia, AbM, Kabat)

<400>  32

Gln Gln Asn Asn Glu Asp Pro Phe Thr 
1               5                   


<210>  33
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 5A7, 48A6, Hz5A7.v5 VH CDR1 (Chothia)

<400>  33

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  34
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 5A7, Hz5A7.v5 VH CDR2 (Chothia)

<400>  34

Ser Gly Gly Gly Ser Tyr 
1               5       


<210>  35
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 5A7, Hz5A7.v5 VH CDR2 (AbM)

<400>  35

Thr Ile Ser Gly Gly Gly Ser Tyr Thr Asn 
1               5                   10  


<210>  36
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 5A7, 48A6, Hz5A7.v5 VH CDR1 (Kabat)

<400>  36

Ser Tyr Gly Met Ser 
1               5   


<210>  37
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 5A7, 48A6, Hz5A7.v5 VH CDR1 (Contact)

<400>  37

Ser Ser Tyr Gly Met Ser 
1               5       


<210>  38
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 5A7, Hz5A7.v5 VH CDR2 (Contact)

<400>  38

Trp Val Ala Thr Ile Ser Gly Gly Gly Ser Tyr Thr Asn 
1               5                   10              


<210>  39
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 5A7 VH CDR3 (Contact)

<400>  39

Ala Arg Arg Glu Trp Arg Met Thr Leu Tyr Ala Met Asp 
1               5                   10              


<210>  40
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 5A7 VL CDR1 (Contact)

<400>  40

Asp Ser Tyr Gly Asn Ser Phe Met His Trp Tyr 
1               5                   10      


<210>  41
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 5A7, Hz5A7.v5 VL CDR2 (Contact)

<400>  41

Leu Leu Ile Tyr Leu Thr Ser Asn Leu Glu 
1               5                   10  


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 5A7, Hz5A7.v5 VL CDR3 (Contact)

<400>  42

Gln Gln Asn Asn Glu Asp Pro Phe 
1               5               


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 12A12, 16C5 VH CDR1 (Exemplary, AbM)

<400>  43

Gly Tyr Thr Phe Thr Asp Tyr Asn Met Asp 
1               5                   10  


<210>  44
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 12A12 VH CDR2 (Exemplary, Kabat)

<400>  44

Tyr Ile Tyr Pro Asn Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe Asn 
1               5                   10                  15      


Ser 
    


<210>  45
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 12A12 VH CDR3 (Exemplary, Chothia, AbM)

<400>  45

Ser Pro Tyr Tyr Asp Tyr Val Gly Ser Tyr Ala Met Asp Tyr 
1               5                   10                  


<210>  46
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 12A12 VL CDR1 (Exemplary, Chothia, AbM, Kabat)

<400>  46

Thr Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210>  47
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 12A12 VL CDR2 (Exemplary, Chothia, AbM, Kabat)

<400>  47

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 12A12 VL CDR3 (Exemplary, Chothia, AbM, Kabat)

<400>  48

His Gln Tyr His Arg Ser Pro Arg Thr 
1               5                   


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 12A12, 16C5 VH CDR1 (Chothia)

<400>  49

Gly Tyr Thr Phe Thr Asp Tyr 
1               5           


<210>  50
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 12A12 VH CDR2 (Chothia)

<400>  50

Tyr Pro Asn Asn Gly Gly 
1               5       


<210>  51
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 12A12 VH CDR2 (AbM)

<400>  51

Tyr Ile Tyr Pro Asn Asn Gly Gly Thr Gly 
1               5                   10  


<210>  52
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 12A12, 16C5 VH CDR1 (Kabat)

<400>  52

Asp Tyr Asn Met Asp 
1               5   


<210>  53
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 12A12, 16C5 VH CDR1 (Contact)

<400>  53

Thr Asp Tyr Asn Met Asp 
1               5       


<210>  54
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 12A12 VH CDR2 (Contact)

<400>  54

Trp Ile Gly Tyr Ile Tyr Pro Asn Asn Gly Gly Thr Gly 
1               5                   10              


<210>  55
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 12A12 VH CDR3 (Contact)

<400>  55

Ala Ser Ser Pro Tyr Tyr Asp Tyr Val Gly Ser Tyr Ala Met Asp 
1               5                   10                  15  


<210>  56
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 12A12 VL CDR1 (Contact)

<400>  56

Ser Ser Ser Tyr Leu His Trp Tyr 
1               5               


<210>  57
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 12A12 VL CDR2 (Contact)

<400>  57

Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala 
1               5                   10  


<210>  58
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 12A12 VL CDR3 (Contact)

<400>  58

His Gln Tyr His Arg Ser Pro Arg 
1               5               


<210>  59
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 16C5 VH CDR2 (Exemplary, Kabat)

<400>  59

Tyr Ile Tyr Pro Ser Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  60
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 16C5 VH CDR3 (Exemplary, Chothia, AbM, Kabat)

<400>  60

Val Pro Tyr Tyr Asp Tyr Leu Tyr Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  


<210>  61
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 16C5 VL CDR1 (Exemplary, Chothia, AbM, Kabat)

<400>  61

Arg Ala Ser Ser Ser Val Ser Phe Met His 
1               5                   10  


<210>  62
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 16C5 VL CDR2 (Exemplary, Chothia, AbM, Kabat)

<400>  62

Ala Thr Ser Asn Leu Ala Ser 
1               5           


<210>  63
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 16C5 VL CDR3 (Exemplary, Chothia, AbM, Kabat)

<400>  63

Gln Gln Trp Ser Thr Asn Pro Tyr Met Tyr Thr 
1               5                   10      


<210>  64
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 16C5 VH CDR2 (Chothia)

<400>  64

Tyr Pro Ser Asn Gly Gly 
1               5       


<210>  65
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 16C5 VH CDR2 (AbM)

<400>  65

Tyr Ile Tyr Pro Ser Asn Gly Gly Thr Gly 
1               5                   10  


<210>  66
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 16C5 VH CDR2 (Contact)

<400>  66

Trp Ile Gly Tyr Ile Tyr Pro Ser Asn Gly Gly Thr Gly 
1               5                   10              


<210>  67
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 16C5 VH CDR3 (Contact)

<400>  67

Ala Arg Val Pro Tyr Tyr Asp Tyr Leu Tyr Tyr Tyr Ala Met Asp 
1               5                   10                  15  


<210>  68
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 16C5 VL CDR1 (Contact)

<400>  68

Ser Phe Met His Trp Tyr 
1               5       


<210>  69
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 16C5 VL CDR2 (Contact)

<400>  69

Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala 
1               5                   10  


<210>  70
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 16C5 VL CDR3 (Contact)

<400>  70

Gln Gln Trp Ser Thr Asn Pro Tyr Met Tyr 
1               5                   10  


<210>  71
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 45G10, 53F10 VH CDR1 (Exemplary, AbM)

<400>  71

Gly Phe Thr Phe Ser Asp Tyr Gly Met His 
1               5                   10  


<210>  72
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 45G10 VH CDR2 (Exemplary, Kabat)

<400>  72

Tyr Ile Phe Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  73
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 45G10, 53F10 VH CDR3 (Exemplary, Chothia, AbM, Kabat)

<400>  73

Ala Asp Gly Arg Gly Ala Met Asp Tyr 
1               5                   


<210>  74
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 45G10 VL CDR1 (Exemplary, Chothia, AbM, Kabat)

<400>  74

Arg Ala Ser Gln Asp Ile Ser Lys Phe Leu Asn 
1               5                   10      


<210>  75
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 45G10, 53F10 VL CDR2 (Exemplary, Chothia, AbM, Kabat)

<400>  75

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 45G10, 53F10 VL CDR3 (Exemplary, Chothia, AbM, Kabat)

<400>  76

Gln Gln Gly Asn Thr Leu Pro Trp Thr 
1               5                   


<210>  77
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 45G10, 53F10 VH CDR1 (Chothia)

<400>  77

Gly Phe Thr Phe Ser Asp Tyr 
1               5           


<210>  78
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 45G10 VH CDR2 (Chothia)

<400>  78

Phe Ser Gly Ser Ser Thr 
1               5       


<210>  79
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 45G10 VH CDR2 (AbM)

<400>  79

Tyr Ile Phe Ser Gly Ser Ser Thr Ile Tyr 
1               5                   10  


<210>  80
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 45G10, 53F10 VH CDR1 (Kabat)

<400>  80

Asp Tyr Gly Met His 
1               5   


<210>  81
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 45G10, 53F10 VH CDR1 (Contact)

<400>  81

Ser Asp Tyr Gly Met His 
1               5       


<210>  82
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 45G10 VH CDR2 (Contact)

<400>  82

Trp Val Ala Tyr Ile Phe Ser Gly Ser Ser Thr Ile Tyr 
1               5                   10              


<210>  83
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 45G10, 53F10 VH CDR3 (Contact)

<400>  83

Ala Arg Ala Asp Gly Arg Gly Ala Met Asp 
1               5                   10  


<210>  84
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 45G10 VL CDR1 (Contact)

<400>  84

Ser Lys Phe Leu Asn Trp Tyr 
1               5           


<210>  85
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 45G10, 53F10 VL CDR2 (Contact)

<400>  85

Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His 
1               5                   10  


<210>  86
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 45G10, 53F10 VL CDR3 (Contact)

<400>  86

Gln Gln Gly Asn Thr Leu Pro Trp 
1               5               


<210>  87
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 48A6 VH CDR2 (Exemplary, Kabat)

<400>  87

Thr Ile Ser Ser Gly Gly Thr Tyr Thr Phe Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  88
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 48A6 VH CDR3 (Exemplary, Chothia, AbM, Kabat)

<400>  88

Arg Gly Trp Leu Leu His Tyr Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  89
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 48A6 VL CDR1 (Exemplary, Chothia, AbM, Kabat)

<400>  89

Arg Pro Ser Glu Ser Val Asp Ser Phe Gly Asn Ser Phe Met His 
1               5                   10                  15  


<210>  90
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 48A6 VL CDR2 (Exemplary, Chothia, AbM, Kabat)

<400>  90

Leu Ser Ser Lys Leu Glu Ser 
1               5           


<210>  91
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 48A6 VL CDR3 (Exemplary, Chothia, AbM, Kabat)

<400>  91

Gln Gln His Asn Glu Asp Pro Phe Thr 
1               5                   


<210>  92
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 48A6 VH CDR2 (Chothia)

<400>  92

Ser Ser Gly Gly Thr Tyr 
1               5       


<210>  93
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 48A6 VH CDR2 (AbM)

<400>  93

Thr Ile Ser Ser Gly Gly Thr Tyr Thr Phe 
1               5                   10  


<210>  94
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 48A6 VH CDR2 (Contact)

<400>  94

Trp Val Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Phe 
1               5                   10              


<210>  95
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 48A6 VH CDR3 (Contact)

<400>  95

Ala Arg Arg Gly Trp Leu Leu His Tyr Tyr Ala Met Asp 
1               5                   10              


<210>  96
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 48A6 VL CDR1 (Contact)

<400>  96

Asp Ser Phe Gly Asn Ser Phe Met His Trp Phe 
1               5                   10      


<210>  97
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 48A6 VL CDR2 (Contact)

<400>  97

Leu Leu Ile Tyr Leu Ser Ser Lys Leu Glu 
1               5                   10  


<210>  98
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 48A6 VL CDR3 (Contact)

<400>  98

Gln Gln His Asn Glu Asp Pro Phe 
1               5               


<210>  99
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 53F10 VH CDR2 (Exemplary, Kabat)

<400>  99

Tyr Ile Ser Thr Gly Ile Ile Thr Val Tyr Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  100
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 53F10 VL CDR1 (Exemplary, Chothia, AbM, Kabat)

<400>  100

Arg Ala Ser Gln Asp Ile Ser Asn Phe Leu Asn 
1               5                   10      


<210>  101
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 53F10 VH CDR2 (Chothia)

<400>  101

Ser Thr Gly Ile Ile Thr 
1               5       


<210>  102
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 53F10 VH CDR2 (AbM)

<400>  102

Tyr Ile Ser Thr Gly Ile Ile Thr Val Tyr 
1               5                   10  


<210>  103
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 53F10 VH CDR2 (Contact)

<400>  103

Trp Val Ala Tyr Ile Ser Thr Gly Ile Ile Thr Val Tyr 
1               5                   10              


<210>  104
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 53F10 VL CDR1 (Contact)

<400>  104

Ser Asn Phe Leu Asn Trp Tyr 
1               5           


<210>  105
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Hz5A7.v5 VH CDR3 (Exemplary, Chothia, AbM, Kabat)

<400>  105

Arg Glu Trp Arg Tyr Thr Leu Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  106
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Hz5A7.v5 VL CDR1 (Exemplary, Chothia, AbM, Kabat)

<400>  106

Arg Ala Ser Glu Ser Val Glu Ser Tyr Gly Ser Ser Phe Met His 
1               5                   10                  15  


<210>  107
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Hz5A7.v5 VH CDR3 (Contact)

<400>  107

Ala Arg Arg Glu Trp Arg Tyr Thr Leu Tyr Ala Met Asp 
1               5                   10              


<210>  108
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Hz5A7.v5 VL CDR1 (Contact)

<400>  108

Glu Ser Tyr Gly Ser Ser Phe Met His Trp Tyr 
1               5                   10      


<210>  109
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A3 Heavy chain variable region amino acid sequence

<400>  109

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Pro Gly Gly Thr Ile Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ser Asp Lys Tyr Asp Gly Gly Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  110
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A3 Light chain variable region amino acid sequence

<400>  110

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Glu Ala Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Ser Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Leu Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  111
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5A7 Heavy chain variable region amino acid sequence

<400>  111

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Ser Tyr Thr Asn Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ala Lys Lys Asn Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Glu Trp Arg Met Thr Leu Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  112
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5A7 Light chain variable region amino acid sequence

<400>  112

Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Thr Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  113
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12A12 Heavy chain variable region amino acid sequence

<400>  113

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Asn Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Asn Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Pro Tyr Tyr Asp Tyr Val Gly Ser Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  114
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12A12 Light chain variable region amino acid sequence

<400>  114

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro 
                85                  90                  95      


Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  115
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16C5 Heavy chain variable region amino acid sequence

<400>  115

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Ser Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Pro Tyr Tyr Asp Tyr Leu Tyr Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  116
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16C5 Light chain variable region amino acid sequence

<400>  116

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ala Cys Arg Ala Ser Ser Ser Val Ser Phe Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Gln Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Thr Asn Pro Tyr Met 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  117
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  45G10 Heavy chain variable region amino acid sequence

<400>  117

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Phe Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Asp Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  118
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  45G10 Light chain variable region amino acid sequence

<400>  118

Asp Val Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Thr Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Asp Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  119
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  48A6 Heavy chain variable region amino acid sequence

<400>  119

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Met Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Phe Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Trp Leu Leu His Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  120
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  48A6 Light chain variable region amino acid sequence

<400>  120

Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Pro Ser Glu Ser Val Asp Ser Phe 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ser Ser Lys Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln His Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  121
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  53F10 Heavy chain variable region amino acid sequence

<400>  121

Glu Val Gln Val Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Thr Gly Ile Ile Thr Val Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Asp Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Ile Val Ser Ser 
        115             


<210>  122
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  53F10 Light chain variable region amino acid sequence

<400>  122

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Thr Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  123
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz5A7.v5 Heavy chain variable region amino acid sequence

<400>  123

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Ser Tyr Thr Asn Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Glu Trp Arg Tyr Thr Leu Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  124
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz5A7.v5 Light chain variable region amino acid sequence

<400>  124

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Glu Ser Tyr 
            20                  25                  30          


Gly Ser Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Thr Ser Asn Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  125
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz5A7.v5 Heavy chain amino acid sequence with signal sequence

<400>  125

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Thr Ile Ser Gly Gly Gly Ser Tyr Thr 
65                  70                  75                  80  


Asn Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Glu Trp Arg Tyr Thr Leu Tyr 
        115                 120                 125             


Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  126
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz5A7.v5 Heavy chain amino acid sequence without signal sequence

<400>  126

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Ser Tyr Thr Asn Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Glu Trp Arg Tyr Thr Leu Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  127
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz5A7.v5 Light chain amino acid sequence with signal sequence

<400>  127

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Glu Ser Val Glu Ser Tyr Gly Ser Ser Phe Met His Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Leu Thr Ser Asn Leu 
65                  70                  75                  80  


Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Asn Asn Glu Asp Pro Phe Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  128
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz5A7.v5 Light chain amino acid sequence without signal sequence

<400>  128

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Glu Ser Tyr 
            20                  25                  30          


Gly Ser Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Thr Ser Asn Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  129
<211>  330
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human IgG1 constant region

<400>  129

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  130
<211>  330
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human IgG1 constant region E233A/L235A

<400>  130

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Ala Leu Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  131
<211>  330
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human IgG1 constant region L234A/L235A

<400>  131

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  132
<211>  330
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human IgG1 constant region L234A/L235A/P329G

<400>  132

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  133
<211>  330
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human IgG1 constant region N297G

<400>  133

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  134
<211>  330
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human IgG1 constant region N297G/H310A

<400>  134

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


Ala Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  135
<211>  107
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human Kappa light chain constant region

<400>  135

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  136
<211>  106
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human Lambda light chain constant region

<400>  136

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  137
<211>  197
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human ILT3 Ig-like C2-type D1 and D2 amino acid sequence without 
       N-terminal domain (aa 27-218)

<400>  137

Gln Ala Gly Pro Leu Pro Lys Pro Thr Leu Trp Ala Glu Pro Gly Ser 
1               5                   10                  15      


Val Ile Ser Trp Gly Asn Ser Val Thr Ile Trp Cys Gln Gly Thr Leu 
            20                  25                  30          


Glu Ala Arg Glu Tyr Arg Leu Asp Lys Glu Glu Ser Pro Ala Pro Trp 
        35                  40                  45              


Asp Arg Gln Asn Pro Leu Glu Pro Lys Asn Lys Ala Arg Phe Ser Ile 
    50                  55                  60                  


Pro Ser Met Thr Glu Asp Tyr Ala Gly Arg Tyr Arg Cys Tyr Tyr Arg 
65                  70                  75                  80  


Ser Pro Val Gly Trp Ser Gln Pro Ser Asp Pro Leu Glu Leu Val Met 
                85                  90                  95      


Thr Gly Ala Tyr Ser Lys Pro Thr Leu Ser Ala Leu Pro Ser Pro Leu 
            100                 105                 110         


Val Thr Ser Gly Lys Ser Val Thr Leu Leu Cys Gln Ser Arg Ser Pro 
        115                 120                 125             


Met Asp Thr Phe Leu Leu Ile Lys Glu Arg Ala Ala His Pro Leu Leu 
    130                 135                 140                 


His Leu Arg Ser Glu His Gly Ala Gln Gln His Gln Ala Glu Phe Pro 
145                 150                 155                 160 


Met Ser Pro Val Thr Ser Val His Gly Gly Thr Tyr Arg Cys Phe Ser 
                165                 170                 175     


Ser His Gly Phe Ser His Tyr Leu Leu Ser His Pro Ser Asp Pro Leu 
            180                 185                 190         


Glu Leu Ile Val Ser 
        195         


<210>  138
<211>  2477
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human Fibronectin with predicted signal sequence

<400>  138

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
            20                  25                  30          


Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
        35                  40                  45              


Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
    50                  55                  60                  


Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
65                  70                  75                  80  


Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                85                  90                  95      


Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
            100                 105                 110         


Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
        115                 120                 125             


Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
    130                 135                 140                 


Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
145                 150                 155                 160 


Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                165                 170                 175     


Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
            180                 185                 190         


Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
        195                 200                 205             


Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
    210                 215                 220                 


Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
225                 230                 235                 240 


Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                245                 250                 255     


Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
            260                 265                 270         


His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
        275                 280                 285             


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
    290                 295                 300                 


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
305                 310                 315                 320 


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                325                 330                 335     


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
            340                 345                 350         


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
        355                 360                 365             


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
    370                 375                 380                 


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
385                 390                 395                 400 


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                405                 410                 415     


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
            420                 425                 430         


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
        435                 440                 445             


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
    450                 455                 460                 


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
465                 470                 475                 480 


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                485                 490                 495     


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
            500                 505                 510         


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
        515                 520                 525             


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
    530                 535                 540                 


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
545                 550                 555                 560 


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                565                 570                 575     


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
            580                 585                 590         


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
        595                 600                 605             


Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
    610                 615                 620                 


Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
625                 630                 635                 640 


Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 
                645                 650                 655     


Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 
            660                 665                 670         


Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 
        675                 680                 685             


His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 
    690                 695                 700                 


Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 
705                 710                 715                 720 


Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 
                725                 730                 735     


Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 
            740                 745                 750         


Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 
        755                 760                 765             


Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 
    770                 775                 780                 


Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 
785                 790                 795                 800 


Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 
                805                 810                 815     


Thr Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 
            820                 825                 830         


Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 
        835                 840                 845             


Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 
    850                 855                 860                 


Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 
865                 870                 875                 880 


Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 
                885                 890                 895     


Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 
            900                 905                 910         


Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 
        915                 920                 925             


Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 
    930                 935                 940                 


Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 
945                 950                 955                 960 


Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 
                965                 970                 975     


Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 
            980                 985                 990         


Gln Thr Thr Lys Leu Asp Ala Pro  Thr Asn Leu Gln Phe  Val Asn Glu 
        995                 1000                 1005             


Thr Asp  Ser Thr Val Leu Val  Arg Trp Thr Pro Pro  Arg Ala Gln 
    1010                 1015                 1020             


Ile Thr  Gly Tyr Arg Leu Thr  Val Gly Leu Thr Arg  Arg Gly Gln 
    1025                 1030                 1035             


Pro Arg  Gln Tyr Asn Val Gly  Pro Ser Val Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Arg Asn  Leu Gln Pro Ala Ser  Glu Tyr Thr Val Ser  Leu Val Ala 
    1055                 1060                 1065             


Ile Lys  Gly Asn Gln Glu Ser  Pro Lys Ala Thr Gly  Val Phe Thr 
    1070                 1075                 1080             


Thr Leu  Gln Pro Gly Ser Ser  Ile Pro Pro Tyr Asn  Thr Glu Val 
    1085                 1090                 1095             


Thr Glu  Thr Thr Ile Val Ile  Thr Trp Thr Pro Ala  Pro Arg Ile 
    1100                 1105                 1110             


Gly Phe  Lys Leu Gly Val Arg  Pro Ser Gln Gly Gly  Glu Ala Pro 
    1115                 1120                 1125             


Arg Glu  Val Thr Ser Asp Ser  Gly Ser Ile Val Val  Ser Gly Leu 
    1130                 1135                 1140             


Thr Pro  Gly Val Glu Tyr Val  Tyr Thr Ile Gln Val  Leu Arg Asp 
    1145                 1150                 1155             


Gly Gln  Glu Arg Asp Ala Pro  Ile Val Asn Lys Val  Val Thr Pro 
    1160                 1165                 1170             


Leu Ser  Pro Pro Thr Asn Leu  His Leu Glu Ala Asn  Pro Asp Thr 
    1175                 1180                 1185             


Gly Val  Leu Thr Val Ser Trp  Glu Arg Ser Thr Thr  Pro Asp Ile 
    1190                 1195                 1200             


Thr Gly  Tyr Arg Ile Thr Thr  Thr Pro Thr Asn Gly  Gln Gln Gly 
    1205                 1210                 1215             


Asn Ser  Leu Glu Glu Val Val  His Ala Asp Gln Ser  Ser Cys Thr 
    1220                 1225                 1230             


Phe Asp  Asn Leu Ser Pro Gly  Leu Glu Tyr Asn Val  Ser Val Tyr 
    1235                 1240                 1245             


Thr Val  Lys Asp Asp Lys Glu  Ser Val Pro Ile Ser  Asp Thr Ile 
    1250                 1255                 1260             


Ile Pro  Glu Val Pro Gln Leu  Thr Asp Leu Ser Phe  Val Asp Ile 
    1265                 1270                 1275             


Thr Asp  Ser Ser Ile Gly Leu  Arg Trp Thr Pro Leu  Asn Ser Ser 
    1280                 1285                 1290             


Thr Ile  Ile Gly Tyr Arg Ile  Thr Val Val Ala Ala  Gly Glu Gly 
    1295                 1300                 1305             


Ile Pro  Ile Phe Glu Asp Phe  Val Asp Ser Ser Val  Gly Tyr Tyr 
    1310                 1315                 1320             


Thr Val  Thr Gly Leu Glu Pro  Gly Ile Asp Tyr Asp  Ile Ser Val 
    1325                 1330                 1335             


Ile Thr  Leu Ile Asn Gly Gly  Glu Ser Ala Pro Thr  Thr Leu Thr 
    1340                 1345                 1350             


Gln Gln  Thr Ala Val Pro Pro  Pro Thr Asp Leu Arg  Phe Thr Asn 
    1355                 1360                 1365             


Ile Gly  Pro Asp Thr Met Arg  Val Thr Trp Ala Pro  Pro Pro Ser 
    1370                 1375                 1380             


Ile Asp  Leu Thr Asn Phe Leu  Val Arg Tyr Ser Pro  Val Lys Asn 
    1385                 1390                 1395             


Glu Glu  Asp Val Ala Glu Leu  Ser Ile Ser Pro Ser  Asp Asn Ala 
    1400                 1405                 1410             


Val Val  Leu Thr Asn Leu Leu  Pro Gly Thr Glu Tyr  Val Val Ser 
    1415                 1420                 1425             


Val Ser  Ser Val Tyr Glu Gln  His Glu Ser Thr Pro  Leu Arg Gly 
    1430                 1435                 1440             


Arg Gln  Lys Thr Gly Leu Asp  Ser Pro Thr Gly Ile  Asp Phe Ser 
    1445                 1450                 1455             


Asp Ile  Thr Ala Asn Ser Phe  Thr Val His Trp Ile  Ala Pro Arg 
    1460                 1465                 1470             


Ala Thr  Ile Thr Gly Tyr Arg  Ile Arg His His Pro  Glu His Phe 
    1475                 1480                 1485             


Ser Gly  Arg Pro Arg Glu Asp  Arg Val Pro His Ser  Arg Asn Ser 
    1490                 1495                 1500             


Ile Thr  Leu Thr Asn Leu Thr  Pro Gly Thr Glu Tyr  Val Val Ser 
    1505                 1510                 1515             


Ile Val  Ala Leu Asn Gly Arg  Glu Glu Ser Pro Leu  Leu Ile Gly 
    1520                 1525                 1530             


Gln Gln  Ser Thr Val Ser Asp  Val Pro Arg Asp Leu  Glu Val Val 
    1535                 1540                 1545             


Ala Ala  Thr Pro Thr Ser Leu  Leu Ile Ser Trp Asp  Ala Pro Ala 
    1550                 1555                 1560             


Val Thr  Val Arg Tyr Tyr Arg  Ile Thr Tyr Gly Glu  Thr Gly Gly 
    1565                 1570                 1575             


Asn Ser  Pro Val Gln Glu Phe  Thr Val Pro Gly Ser  Lys Ser Thr 
    1580                 1585                 1590             


Ala Thr  Ile Ser Gly Leu Lys  Pro Gly Val Asp Tyr  Thr Ile Thr 
    1595                 1600                 1605             


Val Tyr  Ala Val Thr Gly Arg  Gly Asp Ser Pro Ala  Ser Ser Lys 
    1610                 1615                 1620             


Pro Ile  Ser Ile Asn Tyr Arg  Thr Glu Ile Asp Lys  Pro Ser Gln 
    1625                 1630                 1635             


Met Gln  Val Thr Asp Val Gln  Asp Asn Ser Ile Ser  Val Lys Trp 
    1640                 1645                 1650             


Leu Pro  Ser Ser Ser Pro Val  Thr Gly Tyr Arg Val  Thr Thr Thr 
    1655                 1660                 1665             


Pro Lys  Asn Gly Pro Gly Pro  Thr Lys Thr Lys Thr  Ala Gly Pro 
    1670                 1675                 1680             


Asp Gln  Thr Glu Met Thr Ile  Glu Gly Leu Gln Pro  Thr Val Glu 
    1685                 1690                 1695             


Tyr Val  Val Ser Val Tyr Ala  Gln Asn Pro Ser Gly  Glu Ser Gln 
    1700                 1705                 1710             


Pro Leu  Val Gln Thr Ala Val  Thr Asn Ile Asp Arg  Pro Lys Gly 
    1715                 1720                 1725             


Leu Ala  Phe Thr Asp Val Asp  Val Asp Ser Ile Lys  Ile Ala Trp 
    1730                 1735                 1740             


Glu Ser  Pro Gln Gly Gln Val  Ser Arg Tyr Arg Val  Thr Tyr Ser 
    1745                 1750                 1755             


Ser Pro  Glu Asp Gly Ile His  Glu Leu Phe Pro Ala  Pro Asp Gly 
    1760                 1765                 1770             


Glu Glu  Asp Thr Ala Glu Leu  Gln Gly Leu Arg Pro  Gly Ser Glu 
    1775                 1780                 1785             


Tyr Thr  Val Ser Val Val Ala  Leu His Asp Asp Met  Glu Ser Gln 
    1790                 1795                 1800             


Pro Leu  Ile Gly Thr Gln Ser  Thr Ala Ile Pro Ala  Pro Thr Asp 
    1805                 1810                 1815             


Leu Lys  Phe Thr Gln Val Thr  Pro Thr Ser Leu Ser  Ala Gln Trp 
    1820                 1825                 1830             


Thr Pro  Pro Asn Val Gln Leu  Thr Gly Tyr Arg Val  Arg Val Thr 
    1835                 1840                 1845             


Pro Lys  Glu Lys Thr Gly Pro  Met Lys Glu Ile Asn  Leu Ala Pro 
    1850                 1855                 1860             


Asp Ser  Ser Ser Val Val Val  Ser Gly Leu Met Val  Ala Thr Lys 
    1865                 1870                 1875             


Tyr Glu  Val Ser Val Tyr Ala  Leu Lys Asp Thr Leu  Thr Ser Arg 
    1880                 1885                 1890             


Pro Ala  Gln Gly Val Val Thr  Thr Leu Glu Asn Val  Ser Pro Pro 
    1895                 1900                 1905             


Arg Arg  Ala Arg Val Thr Asp  Ala Thr Glu Thr Thr  Ile Thr Ile 
    1910                 1915                 1920             


Ser Trp  Arg Thr Lys Thr Glu  Thr Ile Thr Gly Phe  Gln Val Asp 
    1925                 1930                 1935             


Ala Val  Pro Ala Asn Gly Gln  Thr Pro Ile Gln Arg  Thr Ile Lys 
    1940                 1945                 1950             


Pro Asp  Val Arg Ser Tyr Thr  Ile Thr Gly Leu Gln  Pro Gly Thr 
    1955                 1960                 1965             


Asp Tyr  Lys Ile Tyr Leu Tyr  Thr Leu Asn Asp Asn  Ala Arg Ser 
    1970                 1975                 1980             


Ser Pro  Val Val Ile Asp Ala  Ser Thr Ala Ile Asp  Ala Pro Ser 
    1985                 1990                 1995             


Asn Leu  Arg Phe Leu Ala Thr  Thr Pro Asn Ser Leu  Leu Val Ser 
    2000                 2005                 2010             


Trp Gln  Pro Pro Arg Ala Arg  Ile Thr Gly Tyr Ile  Ile Lys Tyr 
    2015                 2020                 2025             


Glu Lys  Pro Gly Ser Pro Pro  Arg Glu Val Val Pro  Arg Pro Arg 
    2030                 2035                 2040             


Pro Gly  Val Thr Glu Ala Thr  Ile Thr Gly Leu Glu  Pro Gly Thr 
    2045                 2050                 2055             


Glu Tyr  Thr Ile Tyr Val Ile  Ala Leu Lys Asn Asn  Gln Lys Ser 
    2060                 2065                 2070             


Glu Pro  Leu Ile Gly Arg Lys  Lys Thr Asp Glu Leu  Pro Gln Leu 
    2075                 2080                 2085             


Val Thr  Leu Pro His Pro Asn  Leu His Gly Pro Glu  Ile Leu Asp 
    2090                 2095                 2100             


Val Pro  Ser Thr Val Gln Lys  Thr Pro Phe Val Thr  His Pro Gly 
    2105                 2110                 2115             


Tyr Asp  Thr Gly Asn Gly Ile  Gln Leu Pro Gly Thr  Ser Gly Gln 
    2120                 2125                 2130             


Gln Pro  Ser Val Gly Gln Gln  Met Ile Phe Glu Glu  His Gly Phe 
    2135                 2140                 2145             


Arg Arg  Thr Thr Pro Pro Thr  Thr Ala Thr Pro Ile  Arg His Arg 
    2150                 2155                 2160             


Pro Arg  Pro Tyr Pro Pro Asn  Val Gly Glu Glu Ile  Gln Ile Gly 
    2165                 2170                 2175             


His Ile  Pro Arg Glu Asp Val  Asp Tyr His Leu Tyr  Pro His Gly 
    2180                 2185                 2190             


Pro Gly  Leu Asn Pro Asn Ala  Ser Thr Gly Gln Glu  Ala Leu Ser 
    2195                 2200                 2205             


Gln Thr  Thr Ile Ser Trp Ala  Pro Phe Gln Asp Thr  Ser Glu Tyr 
    2210                 2215                 2220             


Ile Ile  Ser Cys His Pro Val  Gly Thr Asp Glu Glu  Pro Leu Gln 
    2225                 2230                 2235             


Phe Arg  Val Pro Gly Thr Ser  Thr Ser Ala Thr Leu  Thr Gly Leu 
    2240                 2245                 2250             


Thr Arg  Gly Ala Thr Tyr Asn  Val Ile Val Glu Ala  Leu Lys Asp 
    2255                 2260                 2265             


Gln Gln  Arg His Lys Val Arg  Glu Glu Val Val Thr  Val Gly Asn 
    2270                 2275                 2280             


Ser Val  Asn Glu Gly Leu Asn  Gln Pro Thr Asp Asp  Ser Cys Phe 
    2285                 2290                 2295             


Asp Pro  Tyr Thr Val Ser His  Tyr Ala Val Gly Asp  Glu Trp Glu 
    2300                 2305                 2310             


Arg Met  Ser Glu Ser Gly Phe  Lys Leu Leu Cys Gln  Cys Leu Gly 
    2315                 2320                 2325             


Phe Gly  Ser Gly His Phe Arg  Cys Asp Ser Ser Arg  Trp Cys His 
    2330                 2335                 2340             


Asp Asn  Gly Val Asn Tyr Lys  Ile Gly Glu Lys Trp  Asp Arg Gln 
    2345                 2350                 2355             


Gly Glu  Asn Gly Gln Met Met  Ser Cys Thr Cys Leu  Gly Asn Gly 
    2360                 2365                 2370             


Lys Gly  Glu Phe Lys Cys Asp  Pro His Glu Ala Thr  Cys Tyr Asp 
    2375                 2380                 2385             


Asp Gly  Lys Thr Tyr His Val  Gly Glu Gln Trp Gln  Lys Glu Tyr 
    2390                 2395                 2400             


Leu Gly  Ala Ile Cys Ser Cys  Thr Cys Phe Gly Gly  Gln Arg Gly 
    2405                 2410                 2415             


Trp Arg  Cys Asp Asn Cys Arg  Arg Pro Gly Gly Glu  Pro Ser Pro 
    2420                 2425                 2430             


Glu Gly  Thr Thr Gly Gln Ser  Tyr Asn Gln Tyr Ser  Gln Arg Tyr 
    2435                 2440                 2445             


His Gln  Arg Thr Asn Thr Asn  Val Asn Cys Pro Ile  Glu Cys Phe 
    2450                 2455                 2460             


Met Pro  Leu Asp Val Gln Ala  Asp Arg Glu Asp Ser  Arg Glu 
    2465                 2470                 2475         


<210>  139
<211>  2446
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human Fibronectin with predicted signal sequence

<400>  139

Gln Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln 
1               5                   10                  15      


Ser Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln 
            20                  25                  30          


Gln Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr 
        35                  40                  45              


Gly Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu 
    50                  55                  60                  


Thr Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr 
65                  70                  75                  80  


Tyr Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly 
                85                  90                  95      


Ala Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu 
            100                 105                 110         


Gly Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu 
        115                 120                 125             


Thr Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly 
    130                 135                 140                 


Glu Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala 
145                 150                 155                 160 


Gly Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly 
                165                 170                 175     


Trp Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile 
            180                 185                 190         


Thr Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser 
        195                 200                 205             


Tyr Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu 
    210                 215                 220                 


Leu Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu 
225                 230                 235                 240 


Arg His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr 
                245                 250                 255     


Asp Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro 
            260                 265                 270         


Pro Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly 
        275                 280                 285             


Met Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys 
    290                 295                 300                 


Leu Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr 
305                 310                 315                 320 


Gly Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn 
                325                 330                 335     


Gly Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His 
            340                 345                 350         


Leu Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser 
        355                 360                 365             


Phe Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser 
    370                 375                 380                 


Asn Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr 
385                 390                 395                 400 


Thr Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly 
                405                 410                 415     


Thr Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met 
            420                 425                 430         


Ala Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg 
        435                 440                 445             


Ile Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg 
    450                 455                 460                 


Cys Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr 
465                 470                 475                 480 


Ser Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val 
                485                 490                 495     


Asn Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys 
            500                 505                 510         


Thr Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp 
        515                 520                 525             


Gln Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser 
    530                 535                 540                 


Trp Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly 
545                 550                 555                 560 


Arg Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser 
                565                 570                 575     


Ser Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro 
            580                 585                 590         


Asn Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser 
        595                 600                 605             


Lys Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys 
    610                 615                 620                 


Glu Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu 
625                 630                 635                 640 


Lys Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr 
                645                 650                 655     


Gly His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser 
            660                 665                 670         


Thr Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser 
        675                 680                 685             


Pro Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser 
    690                 695                 700                 


Phe Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg 
705                 710                 715                 720 


Val Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp 
                725                 730                 735     


Leu Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly 
            740                 745                 750         


Arg Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln 
        755                 760                 765             


Ser Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro 
    770                 775                 780                 


Asp Thr Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp 
785                 790                 795                 800 


Ser Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro 
                805                 810                 815     


Ser Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn 
            820                 825                 830         


Ser Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr 
        835                 840                 845             


Ile Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln 
    850                 855                 860                 


Gln Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg 
865                 870                 875                 880 


Asp Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp 
                885                 890                 895     


Thr Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro 
            900                 905                 910         


Val Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn 
        915                 920                 925             


Thr Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe 
    930                 935                 940                 


Lys Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala 
945                 950                 955                 960 


Gln Gln Thr Thr Lys Leu Asp Ala Pro Thr Asn Leu Gln Phe Val Asn 
                965                 970                 975     


Glu Thr Asp Ser Thr Val Leu Val Arg Trp Thr Pro Pro Arg Ala Gln 
            980                 985                 990         


Ile Thr Gly Tyr Arg Leu Thr Val  Gly Leu Thr Arg Arg  Gly Gln Pro 
        995                 1000                 1005             


Arg Gln  Tyr Asn Val Gly Pro  Ser Val Ser Lys Tyr  Pro Leu Arg 
    1010                 1015                 1020             


Asn Leu  Gln Pro Ala Ser Glu  Tyr Thr Val Ser Leu  Val Ala Ile 
    1025                 1030                 1035             


Lys Gly  Asn Gln Glu Ser Pro  Lys Ala Thr Gly Val  Phe Thr Thr 
    1040                 1045                 1050             


Leu Gln  Pro Gly Ser Ser Ile  Pro Pro Tyr Asn Thr  Glu Val Thr 
    1055                 1060                 1065             


Glu Thr  Thr Ile Val Ile Thr  Trp Thr Pro Ala Pro  Arg Ile Gly 
    1070                 1075                 1080             


Phe Lys  Leu Gly Val Arg Pro  Ser Gln Gly Gly Glu  Ala Pro Arg 
    1085                 1090                 1095             


Glu Val  Thr Ser Asp Ser Gly  Ser Ile Val Val Ser  Gly Leu Thr 
    1100                 1105                 1110             


Pro Gly  Val Glu Tyr Val Tyr  Thr Ile Gln Val Leu  Arg Asp Gly 
    1115                 1120                 1125             


Gln Glu  Arg Asp Ala Pro Ile  Val Asn Lys Val Val  Thr Pro Leu 
    1130                 1135                 1140             


Ser Pro  Pro Thr Asn Leu His  Leu Glu Ala Asn Pro  Asp Thr Gly 
    1145                 1150                 1155             


Val Leu  Thr Val Ser Trp Glu  Arg Ser Thr Thr Pro  Asp Ile Thr 
    1160                 1165                 1170             


Gly Tyr  Arg Ile Thr Thr Thr  Pro Thr Asn Gly Gln  Gln Gly Asn 
    1175                 1180                 1185             


Ser Leu  Glu Glu Val Val His  Ala Asp Gln Ser Ser  Cys Thr Phe 
    1190                 1195                 1200             


Asp Asn  Leu Ser Pro Gly Leu  Glu Tyr Asn Val Ser  Val Tyr Thr 
    1205                 1210                 1215             


Val Lys  Asp Asp Lys Glu Ser  Val Pro Ile Ser Asp  Thr Ile Ile 
    1220                 1225                 1230             


Pro Glu  Val Pro Gln Leu Thr  Asp Leu Ser Phe Val  Asp Ile Thr 
    1235                 1240                 1245             


Asp Ser  Ser Ile Gly Leu Arg  Trp Thr Pro Leu Asn  Ser Ser Thr 
    1250                 1255                 1260             


Ile Ile  Gly Tyr Arg Ile Thr  Val Val Ala Ala Gly  Glu Gly Ile 
    1265                 1270                 1275             


Pro Ile  Phe Glu Asp Phe Val  Asp Ser Ser Val Gly  Tyr Tyr Thr 
    1280                 1285                 1290             


Val Thr  Gly Leu Glu Pro Gly  Ile Asp Tyr Asp Ile  Ser Val Ile 
    1295                 1300                 1305             


Thr Leu  Ile Asn Gly Gly Glu  Ser Ala Pro Thr Thr  Leu Thr Gln 
    1310                 1315                 1320             


Gln Thr  Ala Val Pro Pro Pro  Thr Asp Leu Arg Phe  Thr Asn Ile 
    1325                 1330                 1335             


Gly Pro  Asp Thr Met Arg Val  Thr Trp Ala Pro Pro  Pro Ser Ile 
    1340                 1345                 1350             


Asp Leu  Thr Asn Phe Leu Val  Arg Tyr Ser Pro Val  Lys Asn Glu 
    1355                 1360                 1365             


Glu Asp  Val Ala Glu Leu Ser  Ile Ser Pro Ser Asp  Asn Ala Val 
    1370                 1375                 1380             


Val Leu  Thr Asn Leu Leu Pro  Gly Thr Glu Tyr Val  Val Ser Val 
    1385                 1390                 1395             


Ser Ser  Val Tyr Glu Gln His  Glu Ser Thr Pro Leu  Arg Gly Arg 
    1400                 1405                 1410             


Gln Lys  Thr Gly Leu Asp Ser  Pro Thr Gly Ile Asp  Phe Ser Asp 
    1415                 1420                 1425             


Ile Thr  Ala Asn Ser Phe Thr  Val His Trp Ile Ala  Pro Arg Ala 
    1430                 1435                 1440             


Thr Ile  Thr Gly Tyr Arg Ile  Arg His His Pro Glu  His Phe Ser 
    1445                 1450                 1455             


Gly Arg  Pro Arg Glu Asp Arg  Val Pro His Ser Arg  Asn Ser Ile 
    1460                 1465                 1470             


Thr Leu  Thr Asn Leu Thr Pro  Gly Thr Glu Tyr Val  Val Ser Ile 
    1475                 1480                 1485             


Val Ala  Leu Asn Gly Arg Glu  Glu Ser Pro Leu Leu  Ile Gly Gln 
    1490                 1495                 1500             


Gln Ser  Thr Val Ser Asp Val  Pro Arg Asp Leu Glu  Val Val Ala 
    1505                 1510                 1515             


Ala Thr  Pro Thr Ser Leu Leu  Ile Ser Trp Asp Ala  Pro Ala Val 
    1520                 1525                 1530             


Thr Val  Arg Tyr Tyr Arg Ile  Thr Tyr Gly Glu Thr  Gly Gly Asn 
    1535                 1540                 1545             


Ser Pro  Val Gln Glu Phe Thr  Val Pro Gly Ser Lys  Ser Thr Ala 
    1550                 1555                 1560             


Thr Ile  Ser Gly Leu Lys Pro  Gly Val Asp Tyr Thr  Ile Thr Val 
    1565                 1570                 1575             


Tyr Ala  Val Thr Gly Arg Gly  Asp Ser Pro Ala Ser  Ser Lys Pro 
    1580                 1585                 1590             


Ile Ser  Ile Asn Tyr Arg Thr  Glu Ile Asp Lys Pro  Ser Gln Met 
    1595                 1600                 1605             


Gln Val  Thr Asp Val Gln Asp  Asn Ser Ile Ser Val  Lys Trp Leu 
    1610                 1615                 1620             


Pro Ser  Ser Ser Pro Val Thr  Gly Tyr Arg Val Thr  Thr Thr Pro 
    1625                 1630                 1635             


Lys Asn  Gly Pro Gly Pro Thr  Lys Thr Lys Thr Ala  Gly Pro Asp 
    1640                 1645                 1650             


Gln Thr  Glu Met Thr Ile Glu  Gly Leu Gln Pro Thr  Val Glu Tyr 
    1655                 1660                 1665             


Val Val  Ser Val Tyr Ala Gln  Asn Pro Ser Gly Glu  Ser Gln Pro 
    1670                 1675                 1680             


Leu Val  Gln Thr Ala Val Thr  Asn Ile Asp Arg Pro  Lys Gly Leu 
    1685                 1690                 1695             


Ala Phe  Thr Asp Val Asp Val  Asp Ser Ile Lys Ile  Ala Trp Glu 
    1700                 1705                 1710             


Ser Pro  Gln Gly Gln Val Ser  Arg Tyr Arg Val Thr  Tyr Ser Ser 
    1715                 1720                 1725             


Pro Glu  Asp Gly Ile His Glu  Leu Phe Pro Ala Pro  Asp Gly Glu 
    1730                 1735                 1740             


Glu Asp  Thr Ala Glu Leu Gln  Gly Leu Arg Pro Gly  Ser Glu Tyr 
    1745                 1750                 1755             


Thr Val  Ser Val Val Ala Leu  His Asp Asp Met Glu  Ser Gln Pro 
    1760                 1765                 1770             


Leu Ile  Gly Thr Gln Ser Thr  Ala Ile Pro Ala Pro  Thr Asp Leu 
    1775                 1780                 1785             


Lys Phe  Thr Gln Val Thr Pro  Thr Ser Leu Ser Ala  Gln Trp Thr 
    1790                 1795                 1800             


Pro Pro  Asn Val Gln Leu Thr  Gly Tyr Arg Val Arg  Val Thr Pro 
    1805                 1810                 1815             


Lys Glu  Lys Thr Gly Pro Met  Lys Glu Ile Asn Leu  Ala Pro Asp 
    1820                 1825                 1830             


Ser Ser  Ser Val Val Val Ser  Gly Leu Met Val Ala  Thr Lys Tyr 
    1835                 1840                 1845             


Glu Val  Ser Val Tyr Ala Leu  Lys Asp Thr Leu Thr  Ser Arg Pro 
    1850                 1855                 1860             


Ala Gln  Gly Val Val Thr Thr  Leu Glu Asn Val Ser  Pro Pro Arg 
    1865                 1870                 1875             


Arg Ala  Arg Val Thr Asp Ala  Thr Glu Thr Thr Ile  Thr Ile Ser 
    1880                 1885                 1890             


Trp Arg  Thr Lys Thr Glu Thr  Ile Thr Gly Phe Gln  Val Asp Ala 
    1895                 1900                 1905             


Val Pro  Ala Asn Gly Gln Thr  Pro Ile Gln Arg Thr  Ile Lys Pro 
    1910                 1915                 1920             


Asp Val  Arg Ser Tyr Thr Ile  Thr Gly Leu Gln Pro  Gly Thr Asp 
    1925                 1930                 1935             


Tyr Lys  Ile Tyr Leu Tyr Thr  Leu Asn Asp Asn Ala  Arg Ser Ser 
    1940                 1945                 1950             


Pro Val  Val Ile Asp Ala Ser  Thr Ala Ile Asp Ala  Pro Ser Asn 
    1955                 1960                 1965             


Leu Arg  Phe Leu Ala Thr Thr  Pro Asn Ser Leu Leu  Val Ser Trp 
    1970                 1975                 1980             


Gln Pro  Pro Arg Ala Arg Ile  Thr Gly Tyr Ile Ile  Lys Tyr Glu 
    1985                 1990                 1995             


Lys Pro  Gly Ser Pro Pro Arg  Glu Val Val Pro Arg  Pro Arg Pro 
    2000                 2005                 2010             


Gly Val  Thr Glu Ala Thr Ile  Thr Gly Leu Glu Pro  Gly Thr Glu 
    2015                 2020                 2025             


Tyr Thr  Ile Tyr Val Ile Ala  Leu Lys Asn Asn Gln  Lys Ser Glu 
    2030                 2035                 2040             


Pro Leu  Ile Gly Arg Lys Lys  Thr Asp Glu Leu Pro  Gln Leu Val 
    2045                 2050                 2055             


Thr Leu  Pro His Pro Asn Leu  His Gly Pro Glu Ile  Leu Asp Val 
    2060                 2065                 2070             


Pro Ser  Thr Val Gln Lys Thr  Pro Phe Val Thr His  Pro Gly Tyr 
    2075                 2080                 2085             


Asp Thr  Gly Asn Gly Ile Gln  Leu Pro Gly Thr Ser  Gly Gln Gln 
    2090                 2095                 2100             


Pro Ser  Val Gly Gln Gln Met  Ile Phe Glu Glu His  Gly Phe Arg 
    2105                 2110                 2115             


Arg Thr  Thr Pro Pro Thr Thr  Ala Thr Pro Ile Arg  His Arg Pro 
    2120                 2125                 2130             


Arg Pro  Tyr Pro Pro Asn Val  Gly Glu Glu Ile Gln  Ile Gly His 
    2135                 2140                 2145             


Ile Pro  Arg Glu Asp Val Asp  Tyr His Leu Tyr Pro  His Gly Pro 
    2150                 2155                 2160             


Gly Leu  Asn Pro Asn Ala Ser  Thr Gly Gln Glu Ala  Leu Ser Gln 
    2165                 2170                 2175             


Thr Thr  Ile Ser Trp Ala Pro  Phe Gln Asp Thr Ser  Glu Tyr Ile 
    2180                 2185                 2190             


Ile Ser  Cys His Pro Val Gly  Thr Asp Glu Glu Pro  Leu Gln Phe 
    2195                 2200                 2205             


Arg Val  Pro Gly Thr Ser Thr  Ser Ala Thr Leu Thr  Gly Leu Thr 
    2210                 2215                 2220             


Arg Gly  Ala Thr Tyr Asn Val  Ile Val Glu Ala Leu  Lys Asp Gln 
    2225                 2230                 2235             


Gln Arg  His Lys Val Arg Glu  Glu Val Val Thr Val  Gly Asn Ser 
    2240                 2245                 2250             


Val Asn  Glu Gly Leu Asn Gln  Pro Thr Asp Asp Ser  Cys Phe Asp 
    2255                 2260                 2265             


Pro Tyr  Thr Val Ser His Tyr  Ala Val Gly Asp Glu  Trp Glu Arg 
    2270                 2275                 2280             


Met Ser  Glu Ser Gly Phe Lys  Leu Leu Cys Gln Cys  Leu Gly Phe 
    2285                 2290                 2295             


Gly Ser  Gly His Phe Arg Cys  Asp Ser Ser Arg Trp  Cys His Asp 
    2300                 2305                 2310             


Asn Gly  Val Asn Tyr Lys Ile  Gly Glu Lys Trp Asp  Arg Gln Gly 
    2315                 2320                 2325             


Glu Asn  Gly Gln Met Met Ser  Cys Thr Cys Leu Gly  Asn Gly Lys 
    2330                 2335                 2340             


Gly Glu  Phe Lys Cys Asp Pro  His Glu Ala Thr Cys  Tyr Asp Asp 
    2345                 2350                 2355             


Gly Lys  Thr Tyr His Val Gly  Glu Gln Trp Gln Lys  Glu Tyr Leu 
    2360                 2365                 2370             


Gly Ala  Ile Cys Ser Cys Thr  Cys Phe Gly Gly Gln  Arg Gly Trp 
    2375                 2380                 2385             


Arg Cys  Asp Asn Cys Arg Arg  Pro Gly Gly Glu Pro  Ser Pro Glu 
    2390                 2395                 2400             


Gly Thr  Thr Gly Gln Ser Tyr  Asn Gln Tyr Ser Gln  Arg Tyr His 
    2405                 2410                 2415             


Gln Arg  Thr Asn Thr Asn Val  Asn Cys Pro Ile Glu  Cys Phe Met 
    2420                 2425                 2430             


Pro Leu  Asp Val Gln Ala Asp  Arg Glu Asp Ser Arg  Glu 
    2435                 2440                 2445     


<210>  140
<211>  577
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human Fibronectin fragment containing heparin-binding and 
       collagen-binding domains (~70 kDa fragment)

<400>  140

Gln Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln 
1               5                   10                  15      


Ser Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln 
            20                  25                  30          


Gln Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr 
        35                  40                  45              


Gly Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu 
    50                  55                  60                  


Thr Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr 
65                  70                  75                  80  


Tyr Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly 
                85                  90                  95      


Ala Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu 
            100                 105                 110         


Gly Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu 
        115                 120                 125             


Thr Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly 
    130                 135                 140                 


Glu Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala 
145                 150                 155                 160 


Gly Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly 
                165                 170                 175     


Trp Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile 
            180                 185                 190         


Thr Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser 
        195                 200                 205             


Tyr Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu 
    210                 215                 220                 


Leu Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu 
225                 230                 235                 240 


Arg His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr 
                245                 250                 255     


Asp Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro 
            260                 265                 270         


Pro Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly 
        275                 280                 285             


Met Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys 
    290                 295                 300                 


Leu Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr 
305                 310                 315                 320 


Gly Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn 
                325                 330                 335     


Gly Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His 
            340                 345                 350         


Leu Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser 
        355                 360                 365             


Phe Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser 
    370                 375                 380                 


Asn Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr 
385                 390                 395                 400 


Thr Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly 
                405                 410                 415     


Thr Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met 
            420                 425                 430         


Ala Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg 
        435                 440                 445             


Ile Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg 
    450                 455                 460                 


Cys Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr 
465                 470                 475                 480 


Ser Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val 
                485                 490                 495     


Asn Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys 
            500                 505                 510         


Thr Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp 
        515                 520                 525             


Gln Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser 
    530                 535                 540                 


Trp Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly 
545                 550                 555                 560 


Arg Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser 
                565                 570                 575     


Ser 
    


<210>  141
<211>  241
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human Fibronectin fragment containing heparin-binding domain (~30
       kDa fragment)

<400>  141

Gln Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln 
1               5                   10                  15      


Ser Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln 
            20                  25                  30          


Gln Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr 
        35                  40                  45              


Gly Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu 
    50                  55                  60                  


Thr Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr 
65                  70                  75                  80  


Tyr Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly 
                85                  90                  95      


Ala Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu 
            100                 105                 110         


Gly Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu 
        115                 120                 125             


Thr Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly 
    130                 135                 140                 


Glu Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala 
145                 150                 155                 160 


Gly Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly 
                165                 170                 175     


Trp Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile 
            180                 185                 190         


Thr Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser 
        195                 200                 205             


Tyr Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu 
    210                 215                 220                 


Leu Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu 
225                 230                 235                 240 


Arg 
    


<210>  142
<211>  336
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human Fibronectin fragment containing collagen-binding domain 
       (~45 kDa fragment)

<400>  142

His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
1               5                   10                  15      


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
            20                  25                  30          


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
        35                  40                  45              


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
    50                  55                  60                  


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
65                  70                  75                  80  


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
                85                  90                  95      


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
            100                 105                 110         


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
        115                 120                 125             


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
    130                 135                 140                 


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
145                 150                 155                 160 


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
                165                 170                 175     


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
            180                 185                 190         


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
        195                 200                 205             


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
    210                 215                 220                 


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
225                 230                 235                 240 


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
                245                 250                 255     


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
            260                 265                 270         


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
        275                 280                 285             


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
    290                 295                 300                 


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
305                 310                 315                 320 


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
                325                 330                 335     


<210>  143
<211>  44
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human Fibronectin fragment containing type I repeat 1

<400>  143

Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln Trp 
1               5                   10                  15      


Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly Gly 
            20                  25                  30          


Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala 
        35                  40                  


<210>  144
<211>  44
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human Fibronectin fragment containing type I repeat 2

<400>  144

Glu Thr Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp 
1               5                   10                  15      


Thr Tyr Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile 
            20                  25                  30          


Gly Ala Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala 
        35                  40                  


<210>  145
<211>  44
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human Fibronectin fragment containing type I repeat 3

<400>  145

Asn Arg Cys His Glu Gly Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp 
1               5                   10                  15      


Arg Arg Pro His Glu Thr Gly Gly Tyr Met Leu Glu Cys Val Cys Leu 
            20                  25                  30          


Gly Asn Gly Lys Gly Glu Trp Thr Cys Lys Pro Ile 
        35                  40                  


<210>  146
<211>  46
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human Fibronectin fragment containing type I repeat 4

<400>  146

Ala Glu Lys Cys Phe Asp His Ala Ala Gly Thr Ser Tyr Val Val Gly 
1               5                   10                  15      


Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp Met Met Val Asp Cys Thr 
            20                  25                  30          


Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr Cys Thr Ser Arg 
        35                  40                  45      


<210>  147
<211>  45
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human Fibronectin fragment containing type I repeat 5

<400>  147

Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr Arg Ile Gly Asp 
1               5                   10                  15      


Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu Gln Cys Ile Cys 
            20                  25                  30          


Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg His 
        35                  40                  45  


<210>  148
<211>  372
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human CNTFR-alpha with predicted signal sequence

<400>  148

Met Ala Ala Pro Val Pro Trp Ala Cys Cys Ala Val Leu Ala Ala Ala 
1               5                   10                  15      


Ala Ala Val Val Tyr Ala Gln Arg His Ser Pro Gln Glu Ala Pro His 
            20                  25                  30          


Val Gln Tyr Glu Arg Leu Gly Ser Asp Val Thr Leu Pro Cys Gly Thr 
        35                  40                  45              


Ala Asn Trp Asp Ala Ala Val Thr Trp Arg Val Asn Gly Thr Asp Leu 
    50                  55                  60                  


Ala Pro Asp Leu Leu Asn Gly Ser Gln Leu Val Leu His Gly Leu Glu 
65                  70                  75                  80  


Leu Gly His Ser Gly Leu Tyr Ala Cys Phe His Arg Asp Ser Trp His 
                85                  90                  95      


Leu Arg His Gln Val Leu Leu His Val Gly Leu Pro Pro Arg Glu Pro 
            100                 105                 110         


Val Leu Ser Cys Arg Ser Asn Thr Tyr Pro Lys Gly Phe Tyr Cys Ser 
        115                 120                 125             


Trp His Leu Pro Thr Pro Thr Tyr Ile Pro Asn Thr Phe Asn Val Thr 
    130                 135                 140                 


Val Leu His Gly Ser Lys Ile Met Val Cys Glu Lys Asp Pro Ala Leu 
145                 150                 155                 160 


Lys Asn Arg Cys His Ile Arg Tyr Met His Leu Phe Ser Thr Ile Lys 
                165                 170                 175     


Tyr Lys Val Ser Ile Ser Val Ser Asn Ala Leu Gly His Asn Ala Thr 
            180                 185                 190         


Ala Ile Thr Phe Asp Glu Phe Thr Ile Val Lys Pro Asp Pro Pro Glu 
        195                 200                 205             


Asn Val Val Ala Arg Pro Val Pro Ser Asn Pro Arg Arg Leu Glu Val 
    210                 215                 220                 


Thr Trp Gln Thr Pro Ser Thr Trp Pro Asp Pro Glu Ser Phe Pro Leu 
225                 230                 235                 240 


Lys Phe Phe Leu Arg Tyr Arg Pro Leu Ile Leu Asp Gln Trp Gln His 
                245                 250                 255     


Val Glu Leu Ser Asp Gly Thr Ala His Thr Ile Thr Asp Ala Tyr Ala 
            260                 265                 270         


Gly Lys Glu Tyr Ile Ile Gln Val Ala Ala Lys Asp Asn Glu Ile Gly 
        275                 280                 285             


Thr Trp Ser Asp Trp Ser Val Ala Ala His Ala Thr Pro Trp Thr Glu 
    290                 295                 300                 


Glu Pro Arg His Leu Thr Thr Glu Ala Gln Ala Ala Glu Thr Thr Thr 
305                 310                 315                 320 


Ser Thr Thr Ser Ser Leu Ala Pro Pro Pro Thr Thr Lys Ile Cys Asp 
                325                 330                 335     


Pro Gly Glu Leu Gly Ser Gly Gly Gly Pro Ser Ala Pro Phe Leu Val 
            340                 345                 350         


Ser Val Pro Ile Thr Leu Ala Leu Ala Ala Ala Ala Ala Thr Ala Ser 
        355                 360                 365             


Ser Leu Leu Ile 
    370         


<210>  149
<211>  350
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human CNTFR-alpha without predicted signal sequence

<400>  149

Gln Arg His Ser Pro Gln Glu Ala Pro His Val Gln Tyr Glu Arg Leu 
1               5                   10                  15      


Gly Ser Asp Val Thr Leu Pro Cys Gly Thr Ala Asn Trp Asp Ala Ala 
            20                  25                  30          


Val Thr Trp Arg Val Asn Gly Thr Asp Leu Ala Pro Asp Leu Leu Asn 
        35                  40                  45              


Gly Ser Gln Leu Val Leu His Gly Leu Glu Leu Gly His Ser Gly Leu 
    50                  55                  60                  


Tyr Ala Cys Phe His Arg Asp Ser Trp His Leu Arg His Gln Val Leu 
65                  70                  75                  80  


Leu His Val Gly Leu Pro Pro Arg Glu Pro Val Leu Ser Cys Arg Ser 
                85                  90                  95      


Asn Thr Tyr Pro Lys Gly Phe Tyr Cys Ser Trp His Leu Pro Thr Pro 
            100                 105                 110         


Thr Tyr Ile Pro Asn Thr Phe Asn Val Thr Val Leu His Gly Ser Lys 
        115                 120                 125             


Ile Met Val Cys Glu Lys Asp Pro Ala Leu Lys Asn Arg Cys His Ile 
    130                 135                 140                 


Arg Tyr Met His Leu Phe Ser Thr Ile Lys Tyr Lys Val Ser Ile Ser 
145                 150                 155                 160 


Val Ser Asn Ala Leu Gly His Asn Ala Thr Ala Ile Thr Phe Asp Glu 
                165                 170                 175     


Phe Thr Ile Val Lys Pro Asp Pro Pro Glu Asn Val Val Ala Arg Pro 
            180                 185                 190         


Val Pro Ser Asn Pro Arg Arg Leu Glu Val Thr Trp Gln Thr Pro Ser 
        195                 200                 205             


Thr Trp Pro Asp Pro Glu Ser Phe Pro Leu Lys Phe Phe Leu Arg Tyr 
    210                 215                 220                 


Arg Pro Leu Ile Leu Asp Gln Trp Gln His Val Glu Leu Ser Asp Gly 
225                 230                 235                 240 


Thr Ala His Thr Ile Thr Asp Ala Tyr Ala Gly Lys Glu Tyr Ile Ile 
                245                 250                 255     


Gln Val Ala Ala Lys Asp Asn Glu Ile Gly Thr Trp Ser Asp Trp Ser 
            260                 265                 270         


Val Ala Ala His Ala Thr Pro Trp Thr Glu Glu Pro Arg His Leu Thr 
        275                 280                 285             


Thr Glu Ala Gln Ala Ala Glu Thr Thr Thr Ser Thr Thr Ser Ser Leu 
    290                 295                 300                 


Ala Pro Pro Pro Thr Thr Lys Ile Cys Asp Pro Gly Glu Leu Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Pro Ser Ala Pro Phe Leu Val Ser Val Pro Ile Thr Leu 
                325                 330                 335     


Ala Leu Ala Ala Ala Ala Ala Thr Ala Ser Ser Leu Leu Ile 
            340                 345                 350 


<210>  150
<211>  320
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human CNTFR-alpha - mature form

<400>  150

Gln Arg His Ser Pro Gln Glu Ala Pro His Val Gln Tyr Glu Arg Leu 
1               5                   10                  15      


Gly Ser Asp Val Thr Leu Pro Cys Gly Thr Ala Asn Trp Asp Ala Ala 
            20                  25                  30          


Val Thr Trp Arg Val Asn Gly Thr Asp Leu Ala Pro Asp Leu Leu Asn 
        35                  40                  45              


Gly Ser Gln Leu Val Leu His Gly Leu Glu Leu Gly His Ser Gly Leu 
    50                  55                  60                  


Tyr Ala Cys Phe His Arg Asp Ser Trp His Leu Arg His Gln Val Leu 
65                  70                  75                  80  


Leu His Val Gly Leu Pro Pro Arg Glu Pro Val Leu Ser Cys Arg Ser 
                85                  90                  95      


Asn Thr Tyr Pro Lys Gly Phe Tyr Cys Ser Trp His Leu Pro Thr Pro 
            100                 105                 110         


Thr Tyr Ile Pro Asn Thr Phe Asn Val Thr Val Leu His Gly Ser Lys 
        115                 120                 125             


Ile Met Val Cys Glu Lys Asp Pro Ala Leu Lys Asn Arg Cys His Ile 
    130                 135                 140                 


Arg Tyr Met His Leu Phe Ser Thr Ile Lys Tyr Lys Val Ser Ile Ser 
145                 150                 155                 160 


Val Ser Asn Ala Leu Gly His Asn Ala Thr Ala Ile Thr Phe Asp Glu 
                165                 170                 175     


Phe Thr Ile Val Lys Pro Asp Pro Pro Glu Asn Val Val Ala Arg Pro 
            180                 185                 190         


Val Pro Ser Asn Pro Arg Arg Leu Glu Val Thr Trp Gln Thr Pro Ser 
        195                 200                 205             


Thr Trp Pro Asp Pro Glu Ser Phe Pro Leu Lys Phe Phe Leu Arg Tyr 
    210                 215                 220                 


Arg Pro Leu Ile Leu Asp Gln Trp Gln His Val Glu Leu Ser Asp Gly 
225                 230                 235                 240 


Thr Ala His Thr Ile Thr Asp Ala Tyr Ala Gly Lys Glu Tyr Ile Ile 
                245                 250                 255     


Gln Val Ala Ala Lys Asp Asn Glu Ile Gly Thr Trp Ser Asp Trp Ser 
            260                 265                 270         


Val Ala Ala His Ala Thr Pro Trp Thr Glu Glu Pro Arg His Leu Thr 
        275                 280                 285             


Thr Glu Ala Gln Ala Ala Glu Thr Thr Thr Ser Thr Thr Ser Ser Leu 
    290                 295                 300                 


Ala Pro Pro Pro Thr Thr Lys Ile Cys Asp Pro Gly Glu Leu Gly Ser 
305                 310                 315                 320 


<210>  151
<211>  82
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human CNTFR-alpha fragment containing Ig-like C2 type domain

<400>  151

Gln Arg His Ser Pro Gln Glu Ala Pro His Val Gln Tyr Glu Arg Leu 
1               5                   10                  15      


Gly Ser Asp Val Thr Leu Pro Cys Gly Thr Ala Asn Trp Asp Ala Ala 
            20                  25                  30          


Val Thr Trp Arg Val Asn Gly Thr Asp Leu Ala Pro Asp Leu Leu Asn 
        35                  40                  45              


Gly Ser Gln Leu Val Leu His Gly Leu Glu Leu Gly His Ser Gly Leu 
    50                  55                  60                  


Tyr Ala Cys Phe His Arg Asp Ser Trp His Leu Arg His Gln Val Leu 
65                  70                  75                  80  


Leu His 
        


<210>  152
<211>  118
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human CNTFR-alpha fragment containing FN type III domain 1

<400>  152

Pro Pro Arg Glu Pro Val Leu Ser Cys Arg Ser Asn Thr Tyr Pro Lys 
1               5                   10                  15      


Gly Phe Tyr Cys Ser Trp His Leu Pro Thr Pro Thr Tyr Ile Pro Asn 
            20                  25                  30          


Thr Phe Asn Val Thr Val Leu His Gly Ser Lys Ile Met Val Cys Glu 
        35                  40                  45              


Lys Asp Pro Ala Leu Lys Asn Arg Cys His Ile Arg Tyr Met His Leu 
    50                  55                  60                  


Phe Ser Thr Ile Lys Tyr Lys Val Ser Ile Ser Val Ser Asn Ala Leu 
65                  70                  75                  80  


Gly His Asn Ala Thr Ala Ile Thr Phe Asp Glu Phe Thr Ile Val Lys 
                85                  90                  95      


Pro Asp Pro Pro Glu Asn Val Val Ala Arg Pro Val Pro Ser Asn Pro 
            100                 105                 110         


Arg Arg Leu Glu Val Thr 
        115             


<210>  153
<211>  81
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human CNTFR-alpha fragment containing FN type III domain 2

<400>  153

Trp Gln Thr Pro Ser Thr Trp Pro Asp Pro Glu Ser Phe Pro Leu Lys 
1               5                   10                  15      


Phe Phe Leu Arg Tyr Arg Pro Leu Ile Leu Asp Gln Trp Gln His Val 
            20                  25                  30          


Glu Leu Ser Asp Gly Thr Ala His Thr Ile Thr Asp Ala Tyr Ala Gly 
        35                  40                  45              


Lys Glu Tyr Ile Ile Gln Val Ala Ala Lys Asp Asn Glu Ile Gly Thr 
    50                  55                  60                  


Trp Ser Asp Trp Ser Val Ala Ala His Ala Thr Pro Trp Thr Glu Glu 
65                  70                  75                  80  


Pro 
    


<210>  154
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hexahistidine peptide tag

<400>  154

His His His His His His 
1               5       


<210>  155
<211>  136
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human ILT3 Domain 2 with stem amino acid sequence (aa 124-259)

<400>  155

Pro Thr Leu Ser Ala Leu Pro Ser Pro Leu Val Thr Ser Gly Lys Ser 
1               5                   10                  15      


Val Thr Leu Leu Cys Gln Ser Arg Ser Pro Met Asp Thr Phe Leu Leu 
            20                  25                  30          


Ile Lys Glu Arg Ala Ala His Pro Leu Leu His Leu Arg Ser Glu His 
        35                  40                  45              


Gly Ala Gln Gln His Gln Ala Glu Phe Pro Met Ser Pro Val Thr Ser 
    50                  55                  60                  


Val His Gly Gly Thr Tyr Arg Cys Phe Ser Ser His Gly Phe Ser His 
65                  70                  75                  80  


Tyr Leu Leu Ser His Pro Ser Asp Pro Leu Glu Leu Ile Val Ser Gly 
                85                  90                  95      


Ser Leu Glu Asp Pro Arg Pro Ser Pro Thr Arg Ser Val Ser Thr Ala 
            100                 105                 110         


Ala Gly Pro Glu Asp Gln Pro Leu Met Pro Thr Gly Ser Val Pro His 
        115                 120                 125             


Ser Gly Leu Arg Arg His Trp Glu 
    130                 135     


<210>  156
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz48A6 heavy chain variable region amino acid sequences HC-B0

<400>  156

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Phe Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Trp Leu Leu His Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  157
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz48A6 heavy chain variable region amino acid sequences HC-B1

<400>  157

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Phe Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Trp Leu Leu His Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  158
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz48A6 heavy chain variable region amino acid sequences HC-C0

<400>  158

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Thr Ile Ser Ser Gly Gly Thr Tyr Thr Phe Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Trp Leu Leu His Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  159
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz48A6 heavy chain variable region amino acid sequences HC-C1

<400>  159

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Phe Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Trp Leu Leu His Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  160
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz48A6 heavy chain variable region amino acid sequences HC-C2

<400>  160

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Phe Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Trp Leu Leu His Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  161
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz48A6 light chain variable region amino acid sequence LC-C2

<400>  161

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Pro Ser Glu Ser Val Asp Ser Phe 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ser Ser Lys Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  162
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz45G10 heavy chain variable region amino acid sequence HC-A2

<400>  162

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Phe Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Asp Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  163
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz45G10 heavy chain variable region amino acid sequence HC-B1

<400>  163

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Phe Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Asp Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  164
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz45G10 light chain variable region amino acid sequence LC-A4

<400>  164

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Lys Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


