<110>    Cyron Therapeutics Co., Ltd.

<120>    Antibody specifically binding to MUC-1 and uses thereof

<130>    OPP20220311KR

<150>    KR 10-2022-0010120
<151>    2022-01-24

<160>    115

<170>    koPatentIn 3.0

<210>    1
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-CDR1


<220>
<221>    MOD_RES
<222>    (1)
<223>    Xaa is Asp or Ser


<220>
<221>    MOD_RES
<222>    (5)
<223>    Xaa is Asn, Ser, or His


<400>    1
Xaa Tyr Trp Met Xaa
  1               5


<210>    2
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-CDR1


<400>    2
Asp Tyr Trp Met Asn
  1               5


<210>    3
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-CDR1


<400>    3
Asp Tyr Trp Met Ser
  1               5


<210>    4
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-CDR1


<400>    4
Ser Tyr Trp Met Asn
  1               5


<210>    5
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-CDR1


<400>    5
Ser Tyr Trp Met Ser
  1               5


<210>    6
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-CDR1


<400>    6
Ser Tyr Trp Met His
  1               5


<210>    7
<211>    19
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-CDR2


<220>
<221>    MOD_RES
<222>    (1)
<223>    Xaa is Gln, Phe, or Val


<220>
<221>    MOD_RES
<222>    (3)
<223>    Xaa is Arg or Lys


<220>
<221>    MOD_RES
<222>    (4)
<223>    Xaa is Asn, Ser, Gln, or Tyr


<220>
<221>    MOD_RES
<222>    (6)
<223>    Xaa is Pro or Ala


<220>
<221>    MOD_RES
<222>    (8)
<223>    Xaa is Asn or Gly


<220>
<221>    MOD_RES
<222>    (9)
<223>    Xaa is Tyr, Gly, or Ser


<220>
<221>    MOD_RES
<222>    (10)
<223>    Xaa is Glu or Thr


<220>
<221>    MOD_RES
<222>    (11)
<223>    Xaa is Thr or Lys


<220>
<221>    MOD_RES
<222>    (12)
<223>    Xaa is Tyr or Glu


<220>
<221>    MOD_RES
<222>    (14)
<223>    Xaa is Ser, Ala, or Val


<220>
<221>    MOD_RES
<222>    (15)
<223>    Xaa is Asn, Gln, or Ala


<400>    7
Xaa Ile Xaa Xaa Lys Xaa Tyr Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa Ser
  1               5                  10                  15 

Val Lys Gly
           


<210>    8
<211>    19
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-CDR2


<400>    8
Gln Ile Arg Asn Lys Pro Tyr Asn Tyr Glu Thr Tyr Tyr Ser Asn Ser
  1               5                  10                  15 

Val Lys Gly
           


<210>    9
<211>    19
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-CDR2


<400>    9
Gln Ile Arg Asn Lys Pro Tyr Asn Tyr Glu Thr Tyr Tyr Ser Gln Ser
  1               5                  10                  15 

Val Lys Gly
           


<210>    10
<211>    19
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-CDR2


<400>    10
Gln Ile Arg Ser Lys Pro Tyr Asn Tyr Glu Thr Tyr Tyr Ala Ala Ser
  1               5                  10                  15 

Val Lys Gly
           


<210>    11
<211>    19
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-CDR2


<400>    11
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
  1               5                  10                  15 

Val Lys Gly
           


<210>    12
<211>    19
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-CDR2


<400>    12
Gln Ile Lys Gln Lys Pro Tyr Asn Tyr Glu Lys Tyr Tyr Val Gln Ser
  1               5                  10                  15 

Val Lys Gly
           


<210>    13
<211>    19
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-CDR2


<400>    13
Gln Ile Lys Gln Lys Pro Tyr Gly Gly Glu Lys Tyr Tyr Val Gln Ser
  1               5                  10                  15 

Val Lys Gly
           


<210>    14
<211>    19
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-CDR2


<400>    14
Gln Ile Arg Asn Lys Pro Tyr Asn Tyr Glu Lys Tyr Tyr Ala Gln Ser
  1               5                  10                  15 

Val Lys Gly
           


<210>    15
<211>    19
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-CDR2


<400>    15
Val Ile Arg Tyr Lys Pro Tyr Gly Ser Glu Lys Tyr Tyr Ala Gln Ser
  1               5                  10                  15 

Val Lys Gly
           


<210>    16
<211>    12
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-CDR3


<220>
<221>    MOD_RES
<222>    (10)
<223>    Xaa is Met or Phe


<400>    16
Ala Met Ile Thr Ser Asp Gly Tyr Ala Xaa Asp Tyr
  1               5                  10        


<210>    17
<211>    12
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-CDR3


<400>    17
Ala Met Ile Thr Ser Asp Gly Tyr Ala Met Asp Tyr
  1               5                  10        


<210>    18
<211>    12
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-CDR3


<400>    18
Ala Met Ile Thr Ser Asp Gly Tyr Ala Phe Asp Tyr
  1               5                  10        


<210>    19
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-CDR1


<220>
<221>    MOD_RES
<222>    (1)
<223>    Xaa is Lys or Arg


<220>
<221>    MOD_RES
<222>    (2)
<223>    Xaa is Ser or Ala


<220>
<221>    MOD_RES
<222>    (6)
<223>    Xaa is Leu or Val


<220>
<221>    MOD_RES
<222>    (8)
<223>    Xaa is Leu, Tyr, or His


<220>
<221>    MOD_RES
<222>    (11)
<223>    Xaa is Asn or Ser


<220>
<221>    MOD_RES
<222>    (12)
<223>    Xaa is Gln or Gly


<220>
<221>    MOD_RES
<222>    (13)
<223>    Xaa is Lys or Tyr


<400>    19
Xaa Xaa Ser Gln Ser Xaa Leu Xaa Ser Ser Xaa Xaa Xaa Asn Thr Leu
  1               5                  10                  15 

Ala
   


<210>    20
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-CDR1


<400>    20
Lys Ser Ser Gln Ser Leu Leu Leu Ser Ser Asn Gln Lys Asn Tyr Leu
  1               5                  10                  15 

Ala
   


<210>    21
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-CDR1


<400>    21
Lys Ser Ser Gln Ser Val Leu Leu Ser Ser Asn Gln Lys Asn Tyr Leu
  1               5                  10                  15 

Ala
   


<210>    22
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-CDR1


<400>    22
Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu
  1               5                  10                  15 

Ala
   


<210>    23
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-CDR1


<400>    23
Arg Ser Ser Gln Ser Leu Leu Leu Ser Ser Asn Gln Lys Asn Tyr Leu
  1               5                  10                  15 

Ala
   


<210>    24
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-CDR1


<400>    24
Arg Ala Ser Gln Ser Val Leu Leu Ser Ser Asn Gln Lys Asn Tyr Leu
  1               5                  10                  15 

Ala
   


<210>    25
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-CDR1


<400>    25
Arg Ala Ser Gln Ser Val Leu Leu Ser Ser Ser Gln Lys Asn Tyr Leu
  1               5                  10                  15 

Ala
   


<210>    26
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-CDR1


<400>    26
Arg Ser Ser Gln Ser Leu Leu His Ser Ser Asn Gly Tyr Asn Tyr Leu
  1               5                  10                  15 

Ala
   


<210>    27
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-CDR2


<220>
<221>    MOD_RES
<222>    (2)
<223>    Xaa is Ala or Gly


<220>
<221>    MOD_RES
<222>    (4)
<223>    Xaa is Thr or Ser


<220>
<221>    MOD_RES
<222>    (6)
<223>    Xaa is Glu or Ala


<220>
<221>    MOD_RES
<222>    (7)
<223>    Xaa is Ser or Thr


<400>    27
Trp Xaa Ser Xaa Arg Xaa Xaa
  1               5        


<210>    28
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-CDR2


<400>    28
Trp Ala Ser Thr Arg Glu Ser
  1               5        


<210>    29
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-CDR2


<400>    29
Trp Ala Ser Ser Arg Glu Thr
  1               5        


<210>    30
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-CDR2


<400>    30
Trp Ala Ser Ser Arg Ala Thr
  1               5        


<210>    31
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-CDR2


<400>    31
Trp Gly Ser Thr Arg Glu Ser
  1               5        


<210>    32
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-CDR2


<400>    32
Trp Gly Ser Thr Arg Ala Ser
  1               5        


<210>    33
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-CDR3


<220>
<221>    MOD_RES
<222>    (3)
<223>    Xaa is Cys or Ser


<220>
<221>    MOD_RES
<222>    (5)
<223>    Xaa is Ser or Gln


<220>
<221>    MOD_RES
<222>    (6)
<223>    Xaa is Tyr, Thr, or Ser


<220>
<221>    MOD_RES
<222>    (8)
<223>    Xaa is Leu or Tyr


<400>    33
Gln Gln Xaa Phe Xaa Xaa Pro Xaa Thr
  1               5                


<210>    34
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-CDR3


<400>    34
Gln Gln Cys Phe Ser Tyr Pro Leu Thr
  1               5                


<210>    35
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-CDR3


<400>    35
Gln Gln Ser Phe Ser Tyr Pro Leu Thr
  1               5                


<210>    36
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-CDR3


<400>    36
Gln Gln Ser Phe Ser Thr Pro Tyr Thr
  1               5                


<210>    37
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-CDR3


<400>    37
Gln Gln Ser Phe Ser Ser Pro Tyr Thr
  1               5                


<210>    38
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-CDR3


<400>    38
Gln Gln Ser Phe Gln Thr Pro Tyr Thr
  1               5                


<210>    39
<211>    30
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-FR1


<400>    39
Glu Val Lys Val Asp Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Arg
  1               5                  10                  15 

Pro Met Lys Leu Ser Cys Val Val Ser Gly Ile Thr Phe Ser
             20                  25                  30


<210>    40
<211>    30
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-FR1


<400>    40
Glu Val Lys Val Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Ile Thr Phe Ser
             20                  25                  30


<210>    41
<211>    30
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-FR1


<400>    41
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Ile Thr Phe Gly
             20                  25                  30


<210>    42
<211>    30
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-FR1


<400>    42
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly
             20                  25                  30


<210>    43
<211>    30
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-FR1


<400>    43
Glu Val Lys Val Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser
             20                  25                  30


<210>    44
<211>    30
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-FR1


<400>    44
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser
             20                  25                  30


<210>    45
<211>    30
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-FR1


<400>    45
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
             20                  25                  30


<210>    46
<211>    30
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-FR1


<400>    46
Gln Val Lys Val Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser
             20                  25                  30


<210>    47
<211>    30
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-FR1


<400>    47
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser
             20                  25                  30


<210>    48
<211>    30
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-FR1


<400>    48
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
             20                  25                  30


<210>    49
<211>    14
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-FR2


<400>    49
Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val Ala
  1               5                  10                


<210>    50
<211>    14
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-FR2


<400>    50
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
  1               5                  10                


<210>    51
<211>    14
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-FR2


<400>    51
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
  1               5                  10                


<210>    52
<211>    32
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-FR3


<400>    52
Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser Val Tyr Leu Gln
  1               5                  10                  15 

Met Asn Asn Leu Arg Ala Glu Asp Met Gly Ile Tyr Tyr Cys Thr Trp
             20                  25                  30 




<210>    53
<211>    32
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-FR3


<400>    53
Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala Tyr Leu Gln
  1               5                  10                  15 

Met Ser Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Trp
             20                  25                  30 




<210>    54
<211>    32
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-FR3


<400>    54
Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Ser Ser Val Tyr Leu Gln
  1               5                  10                  15 

Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Trp
             20                  25                  30 




<210>    55
<211>    32
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-FR3


<400>    55
Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Ser Ser Leu Tyr Leu Gln
  1               5                  10                  15 

Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Trp
             20                  25                  30 




<210>    56
<211>    32
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-FR3


<400>    56
Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr Val Tyr Leu Gln
  1               5                  10                  15 

Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Trp
             20                  25                  30 




<210>    57
<211>    32
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-FR3


<400>    57
Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Tyr Leu Gln
  1               5                  10                  15 

Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Trp
             20                  25                  30 




<210>    58
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-FR4


<400>    58
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
  1               5                  10    


<210>    59
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-FR4


<400>    59
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
  1               5                  10    


<210>    60
<211>    23
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-FR1


<400>    60
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly
  1               5                  10                  15 

Glu Lys Val Thr Leu Ile Cys
             20            


<210>    61
<211>    23
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-FR1


<400>    61
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
  1               5                  10                  15 

Glu Arg Ala Thr Ile Ser Cys
             20            


<210>    62
<211>    23
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-FR1


<400>    62
Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
  1               5                  10                  15 

Glu Arg Ala Thr Leu Ser Cys
             20            


<210>    63
<211>    23
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-FR1


<400>    63
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
  1               5                  10                  15 

Glu Arg Ala Thr Leu Ser Cys
             20            


<210>    64
<211>    23
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-FR1


<400>    64
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
  1               5                  10                  15 

Glu Pro Ala Ser Ile Ser Cys
             20            


<210>    65
<211>    15
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-FR2


<400>    65
Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr
  1               5                  10                  15


<210>    66
<211>    15
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-FR2


<400>    66
Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr
  1               5                  10                  15


<210>    67
<211>    15
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-FR2


<400>    67
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr
  1               5                  10                  15


<210>    68
<211>    15
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-FR2


<400>    68
Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr
  1               5                  10                  15


<210>    69
<211>    32
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-FR3


<400>    69
Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr
  1               5                  10                  15 

Leu Thr Ile Asn Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys
             20                  25                  30 




<210>    70
<211>    32
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-FR3


<400>    70
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr
  1               5                  10                  15 

Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys
             20                  25                  30 




<210>    71
<211>    32
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-FR3


<400>    71
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr
  1               5                  10                  15 

Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys
             20                  25                  30 




<210>    72
<211>    32
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-FR3


<400>    72
Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
  1               5                  10                  15 

Leu Thr Ile Ser Arg Val Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys
             20                  25                  30 




<210>    73
<211>    32
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-FR3


<400>    73
Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
  1               5                  10                  15 

Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys
             20                  25                  30 




<210>    74
<211>    31
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-FR3


<400>    74
Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
  1               5                  10                  15 

Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys
             20                  25                  30 




<210>    75
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-FR4


<400>    75
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
  1               5                  10


<210>    76
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-FR4


<400>    76
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
  1               5                  10


<210>    77
<211>    123
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH-chimeric


<400>    77
Glu Val Lys Val Asp Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Arg
  1               5                  10                  15 

Pro Met Lys Leu Ser Cys Val Val Ser Gly Ile Thr Phe Ser Asp Tyr
             20                  25                  30 

Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Gln Ile Arg Asn Lys Pro Tyr Asn Tyr Glu Thr Tyr Tyr Ser Asn
     50                  55                  60 

Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
 65                  70                  75                  80 

Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Met Gly Ile Tyr
                 85                  90                  95 

Tyr Cys Thr Trp Ala Met Ile Thr Ser Asp Gly Tyr Ala Met Asp Tyr
            100                 105                 110 

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
        115                 120            


<210>    78
<211>    123
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH1 (MP1-H349-V1)


<400>    78
Glu Val Lys Val Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Ile Thr Phe Ser Asp Tyr
             20                  25                  30 

Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Gly Gln Ile Arg Asn Lys Pro Tyr Asn Tyr Glu Thr Tyr Tyr Ser Gln
     50                  55                  60 

Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
 65                  70                  75                  80 

Ala Tyr Leu Gln Met Ser Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                 85                  90                  95 

Tyr Cys Thr Trp Ala Met Ile Thr Ser Asp Gly Tyr Ala Met Asp Tyr
            100                 105                 110 

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120            


<210>    79
<211>    123
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH2 (MP1-H349-V2)


<400>    79
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Ile Thr Phe Gly Asp Tyr
             20                  25                  30 

Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Gly Gln Ile Arg Ser Lys Pro Tyr Asn Tyr Glu Thr Tyr Tyr Ala Ala
     50                  55                  60 

Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
 65                  70                  75                  80 

Ala Tyr Leu Gln Met Ser Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                 85                  90                  95 

Tyr Cys Thr Trp Ala Met Ile Thr Ser Asp Gly Tyr Ala Met Asp Tyr
            100                 105                 110 

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120            


<210>    80
<211>    123
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH3 (MP1-H349-V3)


<400>    80
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
             20                  25                  30 

Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
     50                  55                  60 

Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
 65                  70                  75                  80 

Ala Tyr Leu Gln Met Ser Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                 85                  90                  95 

Tyr Cys Thr Trp Ala Met Ile Thr Ser Asp Gly Tyr Ala Phe Asp Tyr
            100                 105                 110 

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120            


<210>    81
<211>    123
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH4 (MP1-H37-V1)


<400>    81
Glu Val Lys Val Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser Asp Tyr
             20                  25                  30 

Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Gln Ile Arg Asn Lys Pro Tyr Asn Tyr Glu Thr Tyr Tyr Ser Asn
     50                  55                  60 

Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Ser Ser
 65                  70                  75                  80 

Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                 85                  90                  95 

Tyr Cys Thr Trp Ala Met Ile Thr Ser Asp Gly Tyr Ala Met Asp Tyr
            100                 105                 110 

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120            


<210>    82
<211>    123
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH5 (MP1-H37-V2)


<400>    82
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser Ser Tyr
             20                  25                  30 

Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Gln Ile Lys Gln Lys Pro Tyr Asn Tyr Glu Lys Tyr Tyr Val Gln
     50                  55                  60 

Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Ser Ser
 65                  70                  75                  80 

Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                 85                  90                  95 

Tyr Cys Ala Trp Ala Met Ile Thr Ser Asp Gly Tyr Ala Met Asp Tyr
            100                 105                 110 

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120            


<210>    83
<211>    123
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH6 (MP1-H37-V3)


<400>    83
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
             20                  25                  30 

Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Gln Ile Lys Gln Lys Pro Tyr Gly Gly Glu Lys Tyr Tyr Val Gln
     50                  55                  60 

Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Ser Ser
 65                  70                  75                  80 

Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                 85                  90                  95 

Tyr Cys Ala Trp Ala Met Ile Thr Ser Asp Gly Tyr Ala Phe Asp Tyr
            100                 105                 110 

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120            


<210>    84
<211>    123
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH7 (MP1-H333-V1)


<400>    84
Gln Val Lys Val Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser Asp Tyr
             20                  25                  30 

Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Gln Ile Arg Asn Lys Pro Tyr Asn Tyr Glu Thr Tyr Tyr Ser Asn
     50                  55                  60 

Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr
 65                  70                  75                  80 

Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                 85                  90                  95 

Tyr Cys Thr Trp Ala Met Ile Thr Ser Asp Gly Tyr Ala Met Asp Tyr
            100                 105                 110 

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120            


<210>    85
<211>    123
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH8 (MP1-H333-V2)


<400>    85
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser Ser Tyr
             20                  25                  30 

Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Gln Ile Arg Asn Lys Pro Tyr Asn Tyr Glu Lys Tyr Tyr Ala Gln
     50                  55                  60 

Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr
 65                  70                  75                  80 

Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                 85                  90                  95 

Tyr Cys Ala Trp Ala Met Ile Thr Ser Asp Gly Tyr Ala Met Asp Tyr
            100                 105                 110 

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120            


<210>    86
<211>    123
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VH9 (MP1-H333-V3)


<400>    86
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
             20                  25                  30 

Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Val Ile Arg Tyr Lys Pro Tyr Gly Ser Glu Lys Tyr Tyr Ala Gln
     50                  55                  60 

Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr
 65                  70                  75                  80 

Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                 85                  90                  95 

Tyr Cys Ala Trp Ala Met Ile Thr Ser Asp Gly Tyr Ala Phe Asp Tyr
            100                 105                 110 

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120            


<210>    87
<211>    113
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL-chimeric


<400>    87
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly
  1               5                  10                  15 

Glu Lys Val Thr Leu Ile Cys Lys Ser Ser Gln Ser Leu Leu Leu Ser
             20                  25                  30 

Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
         35                  40                  45 

Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
     50                  55                  60 

Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
 65                  70                  75                  80 

Ile Asn Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln
                 85                  90                  95 

Cys Phe Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
            100                 105                 110 

Lys
   


<210>    88
<211>    113
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL1 (MP1-L41-V1)


<400>    88
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
  1               5                  10                  15 

Glu Arg Ala Thr Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Leu Ser
             20                  25                  30 

Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
         35                  40                  45 

Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
     50                  55                  60 

Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr
 65                  70                  75                  80 

Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
                 85                  90                  95 

Cys Phe Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile
            100                 105                 110 

Lys
   


<210>    89
<211>    113
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL2 (MP1-L41-V2)


<400>    89
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
  1               5                  10                  15 

Glu Arg Ala Thr Ile Ser Cys Lys Ser Ser Gln Ser Val Leu Leu Ser
             20                  25                  30 

Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
         35                  40                  45 

Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
     50                  55                  60 

Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr
 65                  70                  75                  80 

Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
                 85                  90                  95 

Ser Phe Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile
            100                 105                 110 

Lys
   


<210>    90
<211>    113
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL3 (MP1-L41-V3)


<400>    90
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
  1               5                  10                  15 

Glu Arg Ala Thr Ile Ser Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
             20                  25                  30 

Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
         35                  40                  45 

Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
     50                  55                  60 

Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr
 65                  70                  75                  80 

Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
                 85                  90                  95 

Ser Phe Ser Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile
            100                 105                 110 

Lys
   


<210>    91
<211>    113
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL4 (MP1-L320-V1)


<400>    91
Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
  1               5                  10                  15 

Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln Ser Leu Leu Leu Ser
             20                  25                  30 

Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
         35                  40                  45 

Ala Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Ile
     50                  55                  60 

Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
 65                  70                  75                  80 

Ile Ser Arg Val Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln
                 85                  90                  95 

Cys Phe Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile
            100                 105                 110 

Lys
   


<210>    92
<211>    113
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL5 (MP1-L320-V2)


<400>    92
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
  1               5                  10                  15 

Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Leu Leu Ser
             20                  25                  30 

Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
         35                  40                  45 

Ala Pro Arg Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Thr Gly Ile
     50                  55                  60 

Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
 65                  70                  75                  80 

Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln
                 85                  90                  95 

Ser Phe Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile
            100                 105                 110 

Lys
   


<210>    93
<211>    113
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL6 (MP1-L320-V3)


<400>    93
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
  1               5                  10                  15 

Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Leu Leu Ser
             20                  25                  30 

Ser Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
         35                  40                  45 

Ala Pro Arg Leu Leu Ile Tyr Trp Ala Ser Ser Arg Ala Thr Gly Ile
     50                  55                  60 

Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
 65                  70                  75                  80 

Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln
                 85                  90                  95 

Ser Phe Ser Ser Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile
            100                 105                 110 

Lys
   


<210>    94
<211>    113
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL7 (MP1-L228-V1)


<400>    94
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
  1               5                  10                  15 

Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Leu Ser
             20                  25                  30 

Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Leu Gln Lys Pro Gly Gln
         35                  40                  45 

Ser Pro Gln Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
     50                  55                  60 

Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys
 65                  70                  75                  80 

Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln
                 85                  90                  95 

Cys Phe Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile
            100                 105                 110 

Lys
   


<210>    95
<211>    113
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL8 (MP1-L228-V2)


<400>    95
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
  1               5                  10                  15 

Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Leu Ser
             20                  25                  30 

Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Leu Gln Lys Pro Gly Gln
         35                  40                  45 

Ser Pro Gln Leu Leu Ile Tyr Trp Gly Ser Thr Arg Glu Ser Gly Val
     50                  55                  60 

Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys
 65                  70                  75                  80 

Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln
                 85                  90                  95 

Ser Phe Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile
            100                 105                 110 

Lys
   


<210>    96
<211>    113
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL9 (MP1-L228-V3)


<400>    96
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
  1               5                  10                  15 

Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser
             20                  25                  30 

Ser Asn Gly Tyr Asn Tyr Leu Ala Trp Tyr Leu Gln Lys Pro Gly Gln
         35                  40                  45 

Ser Pro Gln Leu Leu Ile Tyr Trp Gly Ser Thr Arg Ala Ser Gly Val
     50                  55                  60 

Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys
 65                  70                  75                  80 

Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln
                 85                  90                  95 

Ser Phe Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile
            100                 105                 110 

Lys
   


<210>    97
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_OKT3 VH-CDR1


<400>    97
Gly Tyr Thr Phe Thr Arg Tyr Thr
  1               5            


<210>    98
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_OKT3 VH-CDR2


<400>    98
Ile Asn Pro Ser Arg Gly Tyr Thr
  1               5            


<210>    99
<211>    12
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_OKT3 VH-CDR3


<400>    99
Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr
  1               5                  10        


<210>    100
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_OKT3 VL-CDR1


<400>    100
Ala Ser Ser Ser Val Ser Tyr
  1               5        


<210>    101
<211>    3
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_OKT3 VL-CDR2


<400>    101
Asp Thr Ser
  1        


<210>    102
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_OKT3 VL-CDR3


<400>    102
Gln Gln Trp Ser Ser Asn Pro Phe Thr
  1               5                


<210>    103
<211>    119
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_OKT3 VH


<400>    103
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
             20                  25                  30 

Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Val
     50                  55                  60 

Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Phe
 65                  70                  75                  80 

Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys
                 85                  90                  95 

Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp Gly Gln Gly
            100                 105                 110 

Thr Pro Val Thr Val Ser Ser
        115                


<210>    104
<211>    106
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_OKT3 VL


<400>    104
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
             20                  25                  30 

Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr
         35                  40                  45 

Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
     50                  55                  60 

Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu
 65                  70                  75                  80 

Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr
                 85                  90                  95 

Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr
            100                 105    


<210>    105
<211>    107
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_OKT3 VL


<400>    105
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
             20                  25                  30 

Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr
         35                  40                  45 

Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
     50                  55                  60 

Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu
 65                  70                  75                  80 

Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr
                 85                  90                  95 

Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr Arg
            100                 105        


<210>    106
<211>    246
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_OKT3 scFv


<400>    106
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
             20                  25                  30 

Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile
         35                  40                  45 

Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Val
     50                  55                  60 

Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Phe
 65                  70                  75                  80 

Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys
                 85                  90                  95 

Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp Gly Gln Gly
            100                 105                 110 

Thr Pro Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly
        115                 120                 125 

Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Asp Ile Gln Met Thr
    130                 135                 140 

Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile
145                 150                 155                 160 

Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln
                165                 170                 175 

Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu
            180                 185                 190 

Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
        195                 200                 205 

Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr
    210                 215                 220 

Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Gln Cys Thr
225                 230                 235                 240 

Lys Leu Gln Ile Thr Arg
                245    


<210>    107
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_MUC1 antigen band


<400>    107
Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys
  1               5                  10    


<210>    108
<211>    255
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_MUC1 isoform 2 (P15941-2) aa 895~1264


<400>    108
Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala
  1               5                  10                  15 

Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly
             20                  25                  30 

Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro
         35                  40                  45 

Pro Ala His Gly Val Thr Ser Ala Pro Asp Asn Arg Pro Ala Leu Gly
     50                  55                  60 

Ser Thr Ala Pro Pro Val His Asn Val Thr Ser Ala Ser Gly Ser Ala
 65                  70                  75                  80 

Ser Gly Ser Ala Ser Thr Leu Val His Asn Gly Thr Ser Ala Arg Ala
                 85                  90                  95 

Thr Thr Thr Pro Ala Ser Lys Ser Thr Pro Phe Ser Ile Pro Ser His
            100                 105                 110 

His Ser Asp Thr Pro Thr Thr Leu Ala Ser His Ser Thr Lys Thr Asp
        115                 120                 125 

Ala Ser Ser Thr His His Ser Ser Val Pro Pro Leu Thr Ser Ser Asn
    130                 135                 140 

His Ser Thr Ser Pro Gln Leu Ser Thr Gly Val Ser Phe Phe Phe Leu
145                 150                 155                 160 

Ser Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro
                165                 170                 175 

Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe
            180                 185                 190 

Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys
        195                 200                 205 

Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu
    210                 215                 220 

Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys
225                 230                 235                 240 

Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser
                245                 250                 255


<210>    109
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_MUC1 epitope


<400>    109
Pro Ala His Gly Val Thr Ser
  1               5        


<210>    110
<211>    220
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL4 light chain


<400>    110
Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
  1               5                  10                  15 

Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln Ser Leu Leu Leu Ser
             20                  25                  30 

Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
         35                  40                  45 

Ala Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Ile
     50                  55                  60 

Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
 65                  70                  75                  80 

Ile Ser Arg Val Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln
                 85                  90                  95 

Cys Phe Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile
            100                 105                 110 

Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp
        115                 120                 125 

Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
    130                 135                 140 

Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu
145                 150                 155                 160 

Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp
                165                 170                 175 

Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr
            180                 185                 190 

Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
        195                 200                 205 

Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215                 220


<210>    111
<211>    220
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_VL5 light chain


<400>    111
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
  1               5                  10                  15 

Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Leu Leu Ser
             20                  25                  30 

Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
         35                  40                  45 

Ala Pro Arg Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Thr Gly Ile
     50                  55                  60 

Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
 65                  70                  75                  80 

Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln
                 85                  90                  95 

Ser Phe Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile
            100                 105                 110 

Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp
        115                 120                 125 

Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
    130                 135                 140 

Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu
145                 150                 155                 160 

Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp
                165                 170                 175 

Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr
            180                 185                 190 

Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
        195                 200                 205 

Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215                 220


<210>    112
<211>    255
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_LCC version humanized MP1 Light chain #4-OKT3scFv


<400>    112
Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
  1               5                  10                  15 

Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln Ser Leu Leu Leu Ser
             20                  25                  30 

Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
         35                  40                  45 

Ala Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Ile
     50                  55                  60 

Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
 65                  70                  75                  80 

Ile Ser Arg Val Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln
                 85                  90                  95 

Cys Phe Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile
            100                 105                 110 

Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp
        115                 120                 125 

Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
    130                 135                 140 

Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu
145                 150                 155                 160 

Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp
                165                 170                 175 

Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr
            180                 185                 190 

Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
        195                 200                 205 

Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Ser
    210                 215                 220 

Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly
225                 230                 235                 240 

Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys
                245                 250                 255


<210>    113
<211>    255
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_LCC version humanized MP1 Light chain #5-OKT3scFv


<400>    113
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
  1               5                  10                  15 

Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Leu Leu Ser
             20                  25                  30 

Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
         35                  40                  45 

Ala Pro Arg Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Thr Gly Ile
     50                  55                  60 

Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
 65                  70                  75                  80 

Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln
                 85                  90                  95 

Ser Phe Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile
            100                 105                 110 

Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp
        115                 120                 125 

Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
    130                 135                 140 

Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu
145                 150                 155                 160 

Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp
                165                 170                 175 

Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr
            180                 185                 190 

Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
        195                 200                 205 

Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Ser
    210                 215                 220 

Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly
225                 230                 235                 240 

Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys
                245                 250                 255


<210>    114
<211>    255
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_LCN version humanized MP1 Light chain #4-OKT3scFv


<400>    114
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
             20                  25                  30 

Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile
         35                  40                  45 

Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Val
     50                  55                  60 

Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Phe
 65                  70                  75                  80 

Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys
                 85                  90                  95 

Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp Gly Gln Gly
            100                 105                 110 

Thr Pro Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly
        115                 120                 125 

Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Asp Ile Gln Met Thr
    130                 135                 140 

Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile
145                 150                 155                 160 

Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln
                165                 170                 175 

Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu
            180                 185                 190 

Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
        195                 200                 205 

Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr
    210                 215                 220 

Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Gln Cys Thr
225                 230                 235                 240 

Lys Leu Gln Ile Thr Arg Gly Gly Gly Ser Gly Gly Gly Ser Gly
                245                 250                 255


<210>    115
<211>    255
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    synthetic_LCN version humanized MP1 Light chain #5-OKT3scFv


<400>    115
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
             20                  25                  30 

Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile
         35                  40                  45 

Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Val
     50                  55                  60 

Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Phe
 65                  70                  75                  80 

Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys
                 85                  90                  95 

Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp Gly Gln Gly
            100                 105                 110 

Thr Pro Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly
        115                 120                 125 

Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Asp Ile Gln Met Thr
    130                 135                 140 

Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile
145                 150                 155                 160 

Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln
                165                 170                 175 

Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu
            180                 185                 190 

Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
        195                 200                 205 

Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr
    210                 215                 220 

Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Gln Cys Thr
225                 230                 235                 240 

Lys Leu Gln Ile Thr Arg Gly Gly Gly Ser Gly Gly Gly Ser Gly
                245                 250                 255
