               SEQUENCE LISTING

<110> FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO)

<120> TELOMERASE REVERSE TRANSCRIPTASE THERAPY FOR KIDNEY FIBROSIS AND NON-HUMAN ANIMALS THEREOF

<130> 906 411

<160> 49

<170> BiSSAP 1.3.6

<210> 1
<211> 4018
<212> DNA
<213> Homo sapiens


<400> 1
caggcagcgc tgcgtcctgc tgcgcacgtg ggaagccctg gccccggcca cccccgcgat       60

gccgcgcgct ccccgctgcc gagccgtgcg ctccctgctg cgcagccact accgcgaggt      120

gctgccgctg gccacgttcg tgcggcgcct ggggccccag ggctggcggc tggtgcagcg      180

cggggacccg gcggctttcc gcgcgctggt ggcccagtgc ctggtgtgcg tgccctggga      240

cgcacggccg ccccccgccg ccccctcctt ccgccaggtg tcctgcctga aggagctggt      300

ggcccgagtg ctgcagaggc tgtgcgagcg cggcgcgaag aacgtgctgg ccttcggctt      360

cgcgctgctg gacggggccc gcgggggccc ccccgaggcc ttcaccacca gcgtgcgcag      420

ctacctgccc aacacggtga ccgacgcact gcgggggagc ggggcgtggg ggctgctgct      480

gcgccgcgtg ggcgacgacg tgctggttca cctgctggca cgctgcgcgc tctttgtgct      540

ggtggctccc agctgcgcct accaggtgtg cgggccgccg ctgtaccagc tcggcgctgc      600

cactcaggcc cggcccccgc cacacgctag tggaccccga aggcgtctgg gatgcgaacg      660

ggcctggaac catagcgtca gggaggccgg ggtccccctg ggcctgccag ccccgggtgc      720

gaggaggcgc gggggcagtg ccagccgaag tctgccgttg cccaagaggc ccaggcgtgg      780

cgctgcccct gagccggagc ggacgcccgt tgggcagggg tcctgggccc acccgggcag      840

gacgcgtgga ccgagtgacc gtggtttctg tgtggtgtca cctgccagac ccgccgaaga      900

agccacctct ttggagggtg cgctctctgg cacgcgccac tcccacccat ccgtgggccg      960

ccagcaccac gcgggccccc catccacatc gcggccacca cgtccctggg acacgccttg     1020

tcccccggtg tacgccgaga ccaagcactt cctctactcc tcaggcgaca aggagcagct     1080

gcggccctcc ttcctactca gctctctgag gcccagcctg actggcgctc ggaggctcgt     1140

ggagaccatc tttctgggtt ccaggccctg gatgccaggg actccccgca ggttgccccg     1200

cctgccccag cgctactggc aaatgcggcc cctgtttctg gagctgcttg ggaaccacgc     1260

gcagtgcccc tacggggtgc tcctcaagac gcactgcccg ctgcgagctg cggtcacccc     1320

agcagccggt gtctgtgccc gggagaagcc ccagggctct gtggcggccc ccgaggagga     1380

ggacacagac ccccgtcgcc tggtgcagct gctccgccag cacagcagcc cctggcaggt     1440

gtacggcttc gtgcgggcct gcctgcgccg gctggtgccc ccaggcctct ggggctccag     1500

gcacaacgaa cgccgcttcc tcaggaacac caagaagttc atctccctgg ggaagcatgc     1560

caagctctcg ctgcaggagc tgacgtggaa gatgagcgtg cgggactgcg cttggctgcg     1620

caggagccca ggggttggct gtgttccggc cgcagagcac cgtctgcgtg aggagatcct     1680

ggccaagttc ctgcactggc tgatgagtgt gtacgtcgtc gagctgctca ggtctttctt     1740

ttatgtcacg gagaccacgt ttcaaaagaa caggctcttt ttctaccgga agagtgtctg     1800

gagcaagttg caaagcattg gaatcagaca gcacttgaag agggtgcagc tgcgggagct     1860

gtcggaagca gaggtcaggc agcatcggga agccaggccc gccctgctga cgtccagact     1920

ccgcttcatc cccaagcctg acgggctgcg gccgattgtg aacatggact acgtcgtggg     1980

agccagaacg ttccgcagag aaaagagggc cgagcgtctc acctcgaggg tgaaggcact     2040

gttcagcgtg ctcaactacg agcgggcgcg gcgccccggc ctcctgggcg cctctgtgct     2100

gggcctggac gatatccaca gggcctggcg caccttcgtg ctgcgtgtgc gggcccagga     2160

cccgccgcct gagctgtact ttgtcaaggt ggatgtgacg ggcgcgtacg acaccatccc     2220

ccaggacagg ctcacggagg tcatcgccag catcatcaaa ccccagaaca cgtactgcgt     2280

gcgtcggtat gccgtggtcc agaaggccgc ccatgggcac gtccgcaagg ccttcaagag     2340

ccacgtctct accttgacag acctccagcc gtacatgcga cagttcgtgg ctcacctgca     2400

ggagaccagc ccgctgaggg atgccgtcgt catcgagcag agctcctccc tgaatgaggc     2460

cagcagtggc ctcttcgacg tcttcctacg cttcatgtgc caccacgccg tgcgcatcag     2520

gggcaagtcc tacgtccagt gccaggggat cccgcagggc tccatcctct ccacgctgct     2580

ctgcagcctg tgctacggcg acatggagaa caagctgttt gcggggattc ggcgggacgg     2640

gctgctcctg cgtttggtgg atgatttctt gttggtgaca cctcacctca cccacgcgaa     2700

aaccttcctc aggaccctgg tccgaggtgt ccctgagtat ggctgcgtgg tgaacttgcg     2760

gaagacagtg gtgaacttcc ctgtagaaga cgaggccctg ggtggcacgg cttttgttca     2820

gatgccggcc cacggcctat tcccctggtg cggcctgctg ctggataccc ggaccctgga     2880

ggtgcagagc gactactcca gctatgcccg gacctccatc agagccagtc tcaccttcaa     2940

ccgcggcttc aaggctggga ggaacatgcg tcgcaaactc tttggggtct tgcggctgaa     3000

gtgtcacagc ctgtttctgg atttgcaggt gaacagcctc cagacggtgt gcaccaacat     3060

ctacaagatc ctcctgctgc aggcgtacag gtttcacgca tgtgtgctgc agctcccatt     3120

tcatcagcaa gtttggaaga accccacatt tttcctgcgc gtcatctctg acacggcctc     3180

cctctgctac tccatcctga aagccaagaa cgcagggatg tcgctggggg ccaagggcgc     3240

cgccggccct ctgccctccg aggccgtgca gtggctgtgc caccaagcat tcctgctcaa     3300

gctgactcga caccgtgtca cctacgtgcc actcctgggg tcactcagga cagcccagac     3360

gcagctgagt cggaagctcc cggggacgac gctgactgcc ctggaggccg cagccaaccc     3420

ggcactgccc tcagacttca agaccatcct ggactgatgg ccacccgccc acagccaggc     3480

cgagagcaga caccagcagc cctgtcacgc cgggctctac gtcccaggga gggaggggcg     3540

gcccacaccc aggcccgcac cgctgggagt ctgaggcctg agtgagtgtt tggccgaggc     3600

ctgcatgtcc ggctgaaggc tgagtgtccg gctgaggcct gagcgagtgt ccagccaagg     3660

gctgagtgtc cagcacacct gccgtcttca cttccccaca ggctggcgct cggctccacc     3720

ccagggccag cttttcctca ccaggagccc ggcttccact ccccacatag gaatagtcca     3780

tccccagatt cgccattgtt cacccctcgc cctgccctcc tttgccttcc acccccacca     3840

tccaggtgga gaccctgaga aggaccctgg gagctctggg aatttggagt gaccaaaggt     3900

gtgccctgta cacaggcgag gaccctgcac ctggatgggg gtccctgtgg gtcaaattgg     3960

ggggaggtgc tgtgggagta aaatactgaa tatatgagtt tttcagtttt gaaaaaaa       4018


<210> 2
<211> 1132
<212> PRT
<213> Homo sapiens


<400> 2
Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser 
1               5                   10                  15      
His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly 
            20                  25                  30          
Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg 
        35                  40                  45              
Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro 
    50                  55                  60                  
Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu 
65                  70                  75                  80  
Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val 
                85                  90                  95      
Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro 
            100                 105                 110         
Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr 
        115                 120                 125             
Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val 
    130                 135                 140                 
Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val 
145                 150                 155                 160 
Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr 
                165                 170                 175     
Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly 
            180                 185                 190         
Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg 
        195                 200                 205             
Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg 
    210                 215                 220                 
Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg 
225                 230                 235                 240 
Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp 
                245                 250                 255     
Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val 
            260                 265                 270         
Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala 
        275                 280                 285             
Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His 
    290                 295                 300                 
Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro 
305                 310                 315                 320 
Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly 
                325                 330                 335     
Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro 
            340                 345                 350         
Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser 
        355                 360                 365             
Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln 
    370                 375                 380                 
Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His 
385                 390                 395                 400 
Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg 
                405                 410                 415     
Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln 
            420                 425                 430         
Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu 
        435                 440                 445             
Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe 
    450                 455                 460                 
Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser 
465                 470                 475                 480 
Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser 
                485                 490                 495     
Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met 
            500                 505                 510         
Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys 
        515                 520                 525             
Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe 
    530                 535                 540                 
Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe 
545                 550                 555                 560 
Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr 
                565                 570                 575     
Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His 
            580                 585                 590         
Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln 
        595                 600                 605             
His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 
    610                 615                 620                 
Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val 
625                 630                 635                 640 
Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser 
                645                 650                 655     
Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg 
            660                 665                 670         
Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg 
        675                 680                 685             
Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro 
    690                 695                 700                 
Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile 
705                 710                 715                 720 
Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro Gln 
                725                 730                 735     
Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala His 
            740                 745                 750         
Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr Asp 
        755                 760                 765             
Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr Ser 
    770                 775                 780                 
Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu 
785                 790                 795                 800 
Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His His 
                805                 810                 815     
Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile Pro 
            820                 825                 830         
Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp 
        835                 840                 845             
Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu Leu 
    850                 855                 860                 
Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr His Ala 
865                 870                 875                 880 
Lys Thr Phe Leu Arg Thr Leu Val Arg Gly Val Pro Glu Tyr Gly Cys 
                885                 890                 895     
Val Val Asn Leu Arg Lys Thr Val Val Asn Phe Pro Val Glu Asp Glu 
            900                 905                 910         
Ala Leu Gly Gly Thr Ala Phe Val Gln Met Pro Ala His Gly Leu Phe 
        915                 920                 925             
Pro Trp Cys Gly Leu Leu Leu Asp Thr Arg Thr Leu Glu Val Gln Ser 
    930                 935                 940                 
Asp Tyr Ser Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr Phe 
945                 950                 955                 960 
Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe Gly 
                965                 970                 975     
Val Leu Arg Leu Lys Cys His Ser Leu Phe Leu Asp Leu Gln Val Asn 
            980                 985                 990         
Ser Leu Gln Thr Val Cys Thr Asn Ile Tyr Lys Ile Leu Leu Leu Gln 
        995                 1000                1005            
Ala Tyr Arg Phe His Ala Cys Val Leu Gln Leu Pro Phe His Gln Gln 
    1010                1015                1020                
Val Trp Lys Asn Pro Thr Phe Phe Leu Arg Val Ile Ser Asp Thr Ala 
1025                1030                1035                1040
Ser Leu Cys Tyr Ser Ile Leu Lys Ala Lys Asn Ala Gly Met Ser Leu 
                1045                1050                1055    
Gly Ala Lys Gly Ala Ala Gly Pro Leu Pro Ser Glu Ala Val Gln Trp 
            1060                1065                1070        
Leu Cys His Gln Ala Phe Leu Leu Lys Leu Thr Arg His Arg Val Thr 
        1075                1080                1085            
Tyr Val Pro Leu Leu Gly Ser Leu Arg Thr Ala Gln Thr Gln Leu Ser 
    1090                1095                1100                
Arg Lys Leu Pro Gly Thr Thr Leu Thr Ala Leu Glu Ala Ala Ala Asn 
1105                1110                1115                1120
Pro Ala Leu Pro Ser Asp Phe Lys Thr Ile Leu Asp 
                1125                1130        

<210> 3
<211> 3982
<212> DNA
<213> Homo sapiens


<400> 3
caggcagcgc tgcgtcctgc tgcgcacgtg ggaagccctg gccccggcca cccccgcgat       60

gccgcgcgct ccccgctgcc gagccgtgcg ctccctgctg cgcagccact accgcgaggt      120

gctgccgctg gccacgttcg tgcggcgcct ggggccccag ggctggcggc tggtgcagcg      180

cggggacccg gcggctttcc gcgcgctggt ggcccagtgc ctggtgtgcg tgccctggga      240

cgcacggccg ccccccgccg ccccctcctt ccgccaggtg tcctgcctga aggagctggt      300

ggcccgagtg ctgcagaggc tgtgcgagcg cggcgcgaag aacgtgctgg ccttcggctt      360

cgcgctgctg gacggggccc gcgggggccc ccccgaggcc ttcaccacca gcgtgcgcag      420

ctacctgccc aacacggtga ccgacgcact gcgggggagc ggggcgtggg ggctgctgct      480

gcgccgcgtg ggcgacgacg tgctggttca cctgctggca cgctgcgcgc tctttgtgct      540

ggtggctccc agctgcgcct accaggtgtg cgggccgccg ctgtaccagc tcggcgctgc      600

cactcaggcc cggcccccgc cacacgctag tggaccccga aggcgtctgg gatgcgaacg      660

ggcctggaac catagcgtca gggaggccgg ggtccccctg ggcctgccag ccccgggtgc      720

gaggaggcgc gggggcagtg ccagccgaag tctgccgttg cccaagaggc ccaggcgtgg      780

cgctgcccct gagccggagc ggacgcccgt tgggcagggg tcctgggccc acccgggcag      840

gacgcgtgga ccgagtgacc gtggtttctg tgtggtgtca cctgccagac ccgccgaaga      900

agccacctct ttggagggtg cgctctctgg cacgcgccac tcccacccat ccgtgggccg      960

ccagcaccac gcgggccccc catccacatc gcggccacca cgtccctggg acacgccttg     1020

tcccccggtg tacgccgaga ccaagcactt cctctactcc tcaggcgaca aggagcagct     1080

gcggccctcc ttcctactca gctctctgag gcccagcctg actggcgctc ggaggctcgt     1140

ggagaccatc tttctgggtt ccaggccctg gatgccaggg actccccgca ggttgccccg     1200

cctgccccag cgctactggc aaatgcggcc cctgtttctg gagctgcttg ggaaccacgc     1260

gcagtgcccc tacggggtgc tcctcaagac gcactgcccg ctgcgagctg cggtcacccc     1320

agcagccggt gtctgtgccc gggagaagcc ccagggctct gtggcggccc ccgaggagga     1380

ggacacagac ccccgtcgcc tggtgcagct gctccgccag cacagcagcc cctggcaggt     1440

gtacggcttc gtgcgggcct gcctgcgccg gctggtgccc ccaggcctct ggggctccag     1500

gcacaacgaa cgccgcttcc tcaggaacac caagaagttc atctccctgg ggaagcatgc     1560

caagctctcg ctgcaggagc tgacgtggaa gatgagcgtg cgggactgcg cttggctgcg     1620

caggagccca ggggttggct gtgttccggc cgcagagcac cgtctgcgtg aggagatcct     1680

ggccaagttc ctgcactggc tgatgagtgt gtacgtcgtc gagctgctca ggtctttctt     1740

ttatgtcacg gagaccacgt ttcaaaagaa caggctcttt ttctaccgga agagtgtctg     1800

gagcaagttg caaagcattg gaatcagaca gcacttgaag agggtgcagc tgcgggagct     1860

gtcggaagca gaggtcaggc agcatcggga agccaggccc gccctgctga cgtccagact     1920

ccgcttcatc cccaagcctg acgggctgcg gccgattgtg aacatggact acgtcgtggg     1980

agccagaacg ttccgcagag aaaagagggc cgagcgtctc acctcgaggg tgaaggcact     2040

gttcagcgtg ctcaactacg agcgggcgcg gcgccccggc ctcctgggcg cctctgtgct     2100

gggcctggac gatatccaca gggcctggcg caccttcgtg ctgcgtgtgc gggcccagga     2160

cccgccgcct gagctgtact ttgtcaagga caggctcacg gaggtcatcg ccagcatcat     2220

caaaccccag aacacgtact gcgtgcgtcg gtatgccgtg gtccagaagg ccgcccatgg     2280

gcacgtccgc aaggccttca agagccacgt ctctaccttg acagacctcc agccgtacat     2340

gcgacagttc gtggctcacc tgcaggagac cagcccgctg agggatgccg tcgtcatcga     2400

gcagagctcc tccctgaatg aggccagcag tggcctcttc gacgtcttcc tacgcttcat     2460

gtgccaccac gccgtgcgca tcaggggcaa gtcctacgtc cagtgccagg ggatcccgca     2520

gggctccatc ctctccacgc tgctctgcag cctgtgctac ggcgacatgg agaacaagct     2580

gtttgcgggg attcggcggg acgggctgct cctgcgtttg gtggatgatt tcttgttggt     2640

gacacctcac ctcacccacg cgaaaacctt cctcaggacc ctggtccgag gtgtccctga     2700

gtatggctgc gtggtgaact tgcggaagac agtggtgaac ttccctgtag aagacgaggc     2760

cctgggtggc acggcttttg ttcagatgcc ggcccacggc ctattcccct ggtgcggcct     2820

gctgctggat acccggaccc tggaggtgca gagcgactac tccagctatg cccggacctc     2880

catcagagcc agtctcacct tcaaccgcgg cttcaaggct gggaggaaca tgcgtcgcaa     2940

actctttggg gtcttgcggc tgaagtgtca cagcctgttt ctggatttgc aggtgaacag     3000

cctccagacg gtgtgcacca acatctacaa gatcctcctg ctgcaggcgt acaggtttca     3060

cgcatgtgtg ctgcagctcc catttcatca gcaagtttgg aagaacccca catttttcct     3120

gcgcgtcatc tctgacacgg cctccctctg ctactccatc ctgaaagcca agaacgcagg     3180

gatgtcgctg ggggccaagg gcgccgccgg ccctctgccc tccgaggccg tgcagtggct     3240

gtgccaccaa gcattcctgc tcaagctgac tcgacaccgt gtcacctacg tgccactcct     3300

ggggtcactc aggacagccc agacgcagct gagtcggaag ctcccgggga cgacgctgac     3360

tgccctggag gccgcagcca acccggcact gccctcagac ttcaagacca tcctggactg     3420

atggccaccc gcccacagcc aggccgagag cagacaccag cagccctgtc acgccgggct     3480

ctacgtccca gggagggagg ggcggcccac acccaggccc gcaccgctgg gagtctgagg     3540

cctgagtgag tgtttggccg aggcctgcat gtccggctga aggctgagtg tccggctgag     3600

gcctgagcga gtgtccagcc aagggctgag tgtccagcac acctgccgtc ttcacttccc     3660

cacaggctgg cgctcggctc caccccaggg ccagcttttc ctcaccagga gcccggcttc     3720

cactccccac ataggaatag tccatcccca gattcgccat tgttcacccc tcgccctgcc     3780

ctcctttgcc ttccaccccc accatccagg tggagaccct gagaaggacc ctgggagctc     3840

tgggaatttg gagtgaccaa aggtgtgccc tgtacacagg cgaggaccct gcacctggat     3900

gggggtccct gtgggtcaaa ttggggggag gtgctgtggg agtaaaatac tgaatatatg     3960

agtttttcag ttttgaaaaa aa                                              3982


<210> 4
<211> 1120
<212> PRT
<213> Homo sapiens


<400> 4
Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser 
1               5                   10                  15      
His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly 
            20                  25                  30          
Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg 
        35                  40                  45              
Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro 
    50                  55                  60                  
Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu 
65                  70                  75                  80  
Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val 
                85                  90                  95      
Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro 
            100                 105                 110         
Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr 
        115                 120                 125             
Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val 
    130                 135                 140                 
Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val 
145                 150                 155                 160 
Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr 
                165                 170                 175     
Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly 
            180                 185                 190         
Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg 
        195                 200                 205             
Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg 
    210                 215                 220                 
Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg 
225                 230                 235                 240 
Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp 
                245                 250                 255     
Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val 
            260                 265                 270         
Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala 
        275                 280                 285             
Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His 
    290                 295                 300                 
Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro 
305                 310                 315                 320 
Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly 
                325                 330                 335     
Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro 
            340                 345                 350         
Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser 
        355                 360                 365             
Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln 
    370                 375                 380                 
Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His 
385                 390                 395                 400 
Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg 
                405                 410                 415     
Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln 
            420                 425                 430         
Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu 
        435                 440                 445             
Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe 
    450                 455                 460                 
Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser 
465                 470                 475                 480 
Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser 
                485                 490                 495     
Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met 
            500                 505                 510         
Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys 
        515                 520                 525             
Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe 
    530                 535                 540                 
Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe 
545                 550                 555                 560 
Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr 
                565                 570                 575     
Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His 
            580                 585                 590         
Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln 
        595                 600                 605             
His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 
    610                 615                 620                 
Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val 
625                 630                 635                 640 
Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser 
                645                 650                 655     
Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg 
            660                 665                 670         
Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg 
        675                 680                 685             
Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro 
    690                 695                 700                 
Glu Leu Tyr Phe Val Lys Asp Arg Leu Thr Glu Val Ile Ala Ser Ile 
705                 710                 715                 720 
Ile Lys Pro Gln Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln 
                725                 730                 735     
Lys Ala Ala His Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser 
            740                 745                 750         
Thr Leu Thr Asp Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu 
        755                 760                 765             
Gln Glu Thr Ser Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser 
    770                 775                 780                 
Ser Leu Asn Glu Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe 
785                 790                 795                 800 
Met Cys His His Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys 
                805                 810                 815     
Gln Gly Ile Pro Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu 
            820                 825                 830         
Cys Tyr Gly Asp Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp 
        835                 840                 845             
Gly Leu Leu Leu Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His 
    850                 855                 860                 
Leu Thr His Ala Lys Thr Phe Leu Arg Thr Leu Val Arg Gly Val Pro 
865                 870                 875                 880 
Glu Tyr Gly Cys Val Val Asn Leu Arg Lys Thr Val Val Asn Phe Pro 
                885                 890                 895     
Val Glu Asp Glu Ala Leu Gly Gly Thr Ala Phe Val Gln Met Pro Ala 
            900                 905                 910         
His Gly Leu Phe Pro Trp Cys Gly Leu Leu Leu Asp Thr Arg Thr Leu 
        915                 920                 925             
Glu Val Gln Ser Asp Tyr Ser Ser Tyr Ala Arg Thr Ser Ile Arg Ala 
    930                 935                 940                 
Ser Leu Thr Phe Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg 
945                 950                 955                 960 
Lys Leu Phe Gly Val Leu Arg Leu Lys Cys His Ser Leu Phe Leu Asp 
                965                 970                 975     
Leu Gln Val Asn Ser Leu Gln Thr Val Cys Thr Asn Ile Tyr Lys Ile 
            980                 985                 990         
Leu Leu Leu Gln Ala Tyr Arg Phe His Ala Cys Val Leu Gln Leu Pro 
        995                 1000                1005            
Phe His Gln Gln Val Trp Lys Asn Pro Thr Phe Phe Leu Arg Val Ile 
    1010                1015                1020                
Ser Asp Thr Ala Ser Leu Cys Tyr Ser Ile Leu Lys Ala Lys Asn Ala 
1025                1030                1035                1040
Gly Met Ser Leu Gly Ala Lys Gly Ala Ala Gly Pro Leu Pro Ser Glu 
                1045                1050                1055    
Ala Val Gln Trp Leu Cys His Gln Ala Phe Leu Leu Lys Leu Thr Arg 
            1060                1065                1070        
His Arg Val Thr Tyr Val Pro Leu Leu Gly Ser Leu Arg Thr Ala Gln 
        1075                1080                1085            
Thr Gln Leu Ser Arg Lys Leu Pro Gly Thr Thr Leu Thr Ala Leu Glu 
    1090                1095                1100                
Ala Ala Ala Asn Pro Ala Leu Pro Ser Asp Phe Lys Thr Ile Leu Asp 
1105                1110                1115                1120



<210> 5
<211> 3426
<212> DNA
<213> Mus musculus


<400> 5
gtgggaggcc catcccggcc ttgagcacaa tgacccgcgc tcctcgttgc cccgcggtgc       60

gctctctgct gcgcagccga taccgggagg tgtggccgct ggcaaccttt gtgcggcgcc      120

tggggcccga gggcaggcgg cttgtgcaac ccggggaccc gaagatctac cgcactttgg      180

ttgcccaatg cctagtgtgc atgcactggg gctcacagcc tccacctgcc gacctttcct      240

tccaccaggt gtcatccctg aaagagctgg tggccagggt tgtgcagaga ctctgcgagc      300

gcaacgagag aaacgtgctg gcttttggct ttgagctgct taacgaggcc agaggcgggc      360

ctcccatggc cttcactagt agcgtgcgta gctacttgcc caacactgtt attgagaccc      420

tgcgtgtcag tggtgcatgg atgctactgt tgagccgagt gggcgacgac ctgctggtct      480

acctgctggc acactgtgct ctttatcttc tggtgccccc cagctgtgcc taccaggtgt      540

gtgggtctcc cctgtaccaa atttgtgcca ccacggatat ctggccctct gtgtccgcta      600

gttacaggcc cacccgaccc gtgggcagga atttcactaa ccttaggttc ttacaacaga      660

tcaagagcag tagtcgccag gaagcaccga aacccctggc cttgccatct cgaggtacaa      720

agaggcatct gagtctcacc agtacaagtg tgccttcagc taagaaggcc agatgctatc      780

ctgtcccgag agtggaggag ggaccccaca ggcaggtgct accaacccca tcaggcaaat      840

catgggtgcc aagtcctgct cggtcccccg aggtgcctac tgcagagaaa gatttgtctt      900

ctaaaggaaa ggtgtctgac ctgagtctct ctgggtcggt gtgctgtaaa cacaagccca      960

gctccacatc tctgctgtca ccaccccgcc aaaatgcctt tcagctcagg ccatttattg     1020

agaccagaca tttcctttac tccaggggag atggccaaga gcgtctaaac ccctcattcc     1080

tactcagcaa cctccagcct aacttgactg gggccaggag actggtggag atcatctttc     1140

tgggctcaag gcctaggaca tcaggaccac tctgcaggac acaccgtcta tcgcgtcgat     1200

actggcagat gcggcccctg ttccaacagc tgctggtgaa ccatgcagag tgccaatatg     1260

tcagactcct caggtcacat tgcaggtttc gaacagcaaa ccaacaggtg acagatgcct     1320

tgaacaccag cccaccgcac ctcatggatt tgctccgcct gcacagcagt ccctggcagg     1380

tatatggttt tcttcgggcc tgtctctgca aggtggtgtc tgctagtctc tggggtacca     1440

ggcacaatga gcgccgcttc tttaagaact taaagaagtt catctcgttg gggaaatacg     1500

gcaagctatc actgcaggaa ctgatgtgga agatgaaagt agaggattgc cactggctcc     1560

gcagcagccc ggggaaggac cgtgtccccg ctgcagagca ccgtctgagg gagaggatcc     1620

tggctacgtt cctgttctgg ctgatggaca catacgtggt acagctgctt aggtcattct     1680

tttacatcac agagagcaca ttccagaaga acaggctctt cttctaccgt aagagtgtgt     1740

ggagcaagct gcagagcatt ggagtcaggc aacaccttga gagagtgcgg ctacgggagc     1800

tgtcacaaga ggaggtcagg catcaccagg acacctggct agccatgccc atctgcagac     1860

tgcgcttcat ccccaagccc aacggcctgc ggcccattgt gaacatgagt tatagcatgg     1920

gtaccagagc tttgggcaga aggaagcagg cccagcattt cacccagcgt ctcaagactc     1980

tcttcagcat gctcaactat gagcggacaa aacatcctca ccttatgggg tcttctgtac     2040

tgggtatgaa tgacatctac aggacctggc gggcctttgt gctgcgtgtg cgtgctctgg     2100

accagacacc caggatgtac tttgttaagg cagatgtgac cggggcctat gatgccatcc     2160

cccagggtaa gctggtggag gttgttgcca atatgatcag gcactcggag agcacgtact     2220

gtatccgcca gtatgcagtg gtccggagag atagccaagg ccaagtccac aagtccttta     2280

ggagacaggt caccaccctc tctgacctcc agccatacat gggccagttc cttaagcatc     2340

tgcaggattc agatgccagt gcactgagga actccgttgt catcgagcag agcatctcta     2400

tgaatgagag cagcagcagc ctgtttgact tcttcctgca cttcctgcgt cacagtgtcg     2460

taaagattgg tgacaggtgc tatacgcagt gccagggcat cccccagggc tccagcctat     2520

ccaccctgct ctgcagtctg tgtttcggag acatggagaa caagctgttt gctgaggtgc     2580

agcgggatgg gttgctttta cgttttgttg atgactttct gttggtgacg cctcacttgg     2640

accaagcaaa aaccttcctc agcaccctgg tccatggcgt tcctgagtat gggtgcatga     2700

taaacttgca gaagacagtg gtgaacttcc ctgtggagcc tggtaccctg ggtggtgcag     2760

ctccatacca gctgcctgct cactgcctgt ttccctggtg tggcttgctg ctggacactc     2820

agactttgga ggtgttctgt gactactcag gttatgccca gacctcaatt aagacgagcc     2880

tcaccttcca gagtgtcttc aaagctggga agaccatgcg gaacaagctc ctgtcggtct     2940

tgcggttgaa gtgtcacggt ctatttctag acttgcaggt gaacagcctc cagacagtct     3000

gcatcaatat atacaagatc ttcctgcttc aggcctacag gttccatgca tgtgtgattc     3060

agcttccctt tgaccagcgt gttaggaaga acctcacatt ctttctgggc atcatctcca     3120

gccaagcatc ctgctgctat gctatcctga aggtcaagaa tccaggaatg acactaaagg     3180

cctctggctc ctttcctcct gaagccgcac attggctctg ctaccaggcc ttcctgctca     3240

agctggctgc tcattctgtc atctacaaat gtctcctggg acctctgagg acagcccaaa     3300

aactgctgtg ccggaagctc ccagaggcga caatgaccat ccttaaagct gcagctgacc     3360

cagccctaag cacagacttt cagaccattt tggactaacc ctgtctcctt ccgctagatg     3420

aacatg                                                                3426


<210> 6
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Acta2 F

<400> 6
atcaccaact gggacgacat                                                20


<210> 7
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Acta2 R

<400> 7
agtgtcggat gctcttcagg                                                20


<210> 8
<211> 22
<212> DNA
<213> Artificial Sequence


<220> 
<223> Vim F

<400> 8
catgatgctt tgggtaaaat gg                                             22


<210> 9
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Vim R

<400> 9
agtgggtgtc aaccagagga                                                20


<210> 10
<211> 22
<212> DNA
<213> Artificial Sequence


<220> 
<223> Col1a1 F

<400> 10
tggaatcatg gtatttggaa ca                                             22


<210> 11
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Col1a1 R

<400> 11
tagtcgtatg ctgccttggg                                                20


<210> 12
<211> 19
<212> DNA
<213> Artificial Sequence


<220> 
<223> Col1a2 F

<400> 12
cagggcctga tggaaacaa                                                 19


<210> 13
<211> 19
<212> DNA
<213> Artificial Sequence


<220> 
<223> Col1a2 R

<400> 13
acccctctct cctggaagc                                                 19


<210> 14
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Col3a1 F

<400> 14
ataatgggga acgtggtcct                                                20


<210> 15
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Col3a1 R

<400> 15
tgaccatctg atccagggtt                                                20


<210> 16
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> Col4a1 F

<400> 16
gtctggcttc tgctgctctt c                                              21


<210> 17
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Col4a1 R

<400> 17
tcacattttc cacagccaga                                                20


<210> 18
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Fn1 F

<400> 18
cctgggagaa gtttgtgcat                                                20


<210> 19
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> Fn1 R

<400> 19
acttggacag gtccagttgt g                                              21


<210> 20
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Emr1 F

<400> 20
gcaccatctt gctggagact                                                20


<210> 21
<211> 22
<212> DNA
<213> Artificial Sequence


<220> 
<223> Emr1 R

<400> 21
ttcattgatg actttgcttt cg                                             22


<210> 22
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Tgfb1 F

<400> 22
ggagagccct ggataccaac                                                20


<210> 23
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Tgfb1 R

<400> 23
atccacttcc aacccaggtc                                                20


<210> 24
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Snai1 F

<400> 24
accctgctgg tatctctccc                                                20


<210> 25
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Snai1 R

<400> 25
tcttcacatc cgagtgggtt                                                20


<210> 26
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Snai2 F

<400> 26
ggctgcttca aggacacatt                                                20


<210> 27
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Snai2 R

<400> 27
gtgccctcag gtttgatctg                                                20


<210> 28
<211> 19
<212> DNA
<213> Artificial Sequence


<220> 
<223> Zeb1 F

<400> 28
ccaagaactg ctggcaaga                                                 19


<210> 29
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Zeb1 R

<400> 29
ttcggatcat ggttttgctc                                                20


<210> 30
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Zeb2 F

<400> 30
aaacaagcca atcccaggag                                                20


<210> 31
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Zeb2 R

<400> 31
gagggtttgc aaggctatca                                                20


<210> 32
<211> 18
<212> DNA
<213> Artificial Sequence


<220> 
<223> Twist F

<400> 32
cacgctgccc tcggacaa                                                  18


<210> 33
<211> 18
<212> DNA
<213> Artificial Sequence


<220> 
<223> Twist R

<400> 33
gggacgcgga catggacc                                                  18


<210> 34
<211> 22
<212> DNA
<213> Artificial Sequence


<220> 
<223> Kim-1 F

<400> 34
ctctacctcc actcctccaa ca                                             22


<210> 35
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> Kim-1 R

<400> 35
ctcctgagga tgtcacagtg c                                              21


<210> 36
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> NGAL F

<400> 36
caatgtcacc tccatcctgg                                                20


<210> 37
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> NGAL R

<400> 37
cctggagctt ggaacaaatg                                                20


<210> 38
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> Smad3 F

<400> 38
tgaacaccaa gtgcattacc a                                              21


<210> 39
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Smad3 R

<400> 39
aggcggcagt agataacgtg                                                20


<210> 40
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> Cdh1 F

<400> 40
gcagaactgt ccctgtccca g                                              21


<210> 41
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> Cdh1 R

<400> 41
gaacagcacg tacacagccc t                                              21


<210> 42
<211> 22
<212> DNA
<213> Artificial Sequence


<220> 
<223> Loxl2 F

<400> 42
cctacaaccc caaagcctat aa                                             22


<210> 43
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> Loxl2 R

<400> 43
cgtgcagttc atagaaaact tcc                                            23


<210> 44
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> GAPDH F

<400> 44
aggtcggtgt gaacggattt g                                              21


<210> 45
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> GAPDH R

<400> 45
tgtagaccat gtagttgagg tca                                            23


<210> 46
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Trf1 F

<400> 46
tggaaaatga gaaagcgagg                                                20


<210> 47
<211> 22
<212> DNA
<213> Artificial Sequence


<220> 
<223> Trf1 R

<400> 47
tttctgtaga ctgctggcca tt                                             22


<210> 48
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> mTERT F

<400> 48
ggtgacagat gccttgaaca c                                              21


<210> 49
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> mTERT R

<400> 49
gatcctctcc ctcagacggt                                                20


