                         SEQUENCE LISTING

<110>  ϺƼɷ޹˾
 
<120>  CD70׿弰;

<130>  219639

<160>  52    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  1

Gly Ser Ile Phe Ser Ile Asn Ala 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  2

Gly Ser Ile Phe Ser Met Asn Ala 
1               5               


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  3

Arg Ser Ile Phe Ser Ile Asn Ala 
1               5               


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  4

Gly Phe Thr Leu Asp Gly Tyr Ala 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  5

Gly Asn Ile Phe Ser Asn Asn Ala 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  6

Gly Arg Thr Ser Ser Thr Tyr Ala 
1               5               


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  7

Gly Phe Thr Leu Asp Tyr Tyr Ala 
1               5               


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  8

Cys Asp Arg Ile Thr Ser Gly Gly Ser Thr 
1               5                   10  


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  9

Ile Ser Ser Ser Asp Gly Ser Thr 
1               5               


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  10

Ile Thr Ser Asp Gly Ser Thr 
1               5           


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  11

Ile Gly Trp Ser Gly Gly Arg Thr 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  12

Ile Thr Trp Ser Gly Gly Arg Thr 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  13

Ile Ser Ser Ser Ser Asp Gly Ser 
1               5               


<210>  14
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  14

Asn Ala Gly Ala Gly Arg Ala Phe Pro Gly Asp Tyr 
1               5                   10          


<210>  15
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  15

Asn Ser Gly Ala Gly Arg Ala Phe Pro Gly Asp Tyr 
1               5                   10          


<210>  16
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  16

Thr Thr Asp Val Leu Thr Ser Cys Arg Ser Asp Arg Trp Leu Glu Val 
1               5                   10                  15      


<210>  17
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  17

Asn Ala Gly Ala Gly Arg Ala Phe Pro Gly Asp Tyr 
1               5                   10          


<210>  18
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  18

Ala Ala Asp Ser Glu Gln Ser Ser Ser Ser Glu Gly Gln Ala Tyr Gly 
1               5                   10                  15      


Tyr Glu Asp 
            


<210>  19
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  19

Ala Ala Asp Ser Glu Val Ser Ser Ser Ser Glu Gly Gln Tyr Gly Tyr 
1               5                   10                  15      


Glu Ser 
        


<210>  20
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  20

Cys Ser Thr Asp Val Leu Thr Ser Cys Arg Ser Asp Arg Tyr Leu Glu 
1               5                   10                  15      


Val 
    


<210>  21
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH

<400>  21

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Gly Ala Gly Arg Ala Phe Pro Gly Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  22
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH

<400>  22

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Met Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Gly Ser Thr Asn Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Gly Ala Gly Arg Ala Phe Pro Gly Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  23
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH

<400>  23

Glu Val Gln Val Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ile Phe Ser Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ser Gly Ala Gly Arg Ala Phe Pro Gly Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  24
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH

<400>  24

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Phe Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Gly Tyr 
            20                  25                  30          


Ala Val Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ile Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Thr Arg Asn Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Asp Val Leu Thr Ser Cys Arg Ser Asp Arg Trp Leu Glu Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  25
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH

<400>  25

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Phe Ser Asn Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Asp Gly Ser Thr Asn Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Leu Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Gly Ala Gly Arg Ala Phe Pro Gly Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  26
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH

<400>  26

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Ser Ser Thr Tyr 
            20                  25                  30          


Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ile Val 
        35                  40                  45              


Ala Val Ile Gly Trp Ser Gly Gly Arg Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ala Lys Asp Asn Ala Lys Asn Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Ser Glu Gln Ser Ser Ser Ser Glu Gly Gln Ala Tyr Gly 
            100                 105                 110         


Tyr Glu Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  27
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH

<400>  27

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Ser Ser Thr Tyr 
            20                  25                  30          


Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ile Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Arg Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ala Lys Asp Ser Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Ser Glu Val Ser Ser Ser Ser Glu Gly Gln Tyr Gly Tyr 
            100                 105                 110         


Glu Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  28
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH

<400>  28

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Val Asp Ser 
    50                  55                  60                  


Val Leu Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Glu Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ser Thr Asp Val Leu Thr Ser Cys Arg Ser Asp Arg Tyr Leu Glu 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Gly 
        115                 120                 


<210>  29
<211>  346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR

<400>  29

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Gly Ala Gly Arg Ala Phe Pro Gly Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
        115                 120                 125             


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
    130                 135                 140                 


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
145                 150                 155                 160 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
                165                 170                 175     


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Phe Ser Val Val 
            180                 185                 190         


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
        195                 200                 205             


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
    210                 215                 220                 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
225                 230                 235                 240 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
                245                 250                 255     


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            260                 265                 270         


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
        275                 280                 285             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    290                 295                 300                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
305                 310                 315                 320 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                325                 330                 335     


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            340                 345     


<210>  30
<211>  346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR

<400>  30

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Met Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Gly Ser Thr Asn Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Gly Ala Gly Arg Ala Phe Pro Gly Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
        115                 120                 125             


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
    130                 135                 140                 


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
145                 150                 155                 160 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
                165                 170                 175     


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Phe Ser Val Val 
            180                 185                 190         


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
        195                 200                 205             


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
    210                 215                 220                 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
225                 230                 235                 240 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
                245                 250                 255     


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            260                 265                 270         


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
        275                 280                 285             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    290                 295                 300                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
305                 310                 315                 320 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                325                 330                 335     


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            340                 345     


<210>  31
<211>  346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR

<400>  31

Glu Val Gln Val Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ile Phe Ser Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ser Gly Ala Gly Arg Ala Phe Pro Gly Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
        115                 120                 125             


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
    130                 135                 140                 


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
145                 150                 155                 160 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
                165                 170                 175     


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Phe Ser Val Val 
            180                 185                 190         


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
        195                 200                 205             


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
    210                 215                 220                 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
225                 230                 235                 240 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
                245                 250                 255     


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            260                 265                 270         


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
        275                 280                 285             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    290                 295                 300                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
305                 310                 315                 320 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                325                 330                 335     


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            340                 345     


<210>  32
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Phe Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Gly Tyr 
            20                  25                  30          


Ala Val Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ile Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Thr Arg Asn Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Asp Val Leu Thr Ser Cys Arg Ser Asp Arg Trp Leu Glu Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala 
        115                 120                 125             


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
    130                 135                 140                 


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
145                 150                 155                 160 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
                165                 170                 175     


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
            180                 185                 190         


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
        195                 200                 205             


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
    210                 215                 220                 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
225                 230                 235                 240 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
                245                 250                 255     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            260                 265                 270         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        275                 280                 285             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    290                 295                 300                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
305                 310                 315                 320 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                325                 330                 335     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            340                 345                 350     


<210>  33
<211>  346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR

<400>  33

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Phe Ser Asn Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Asp Gly Ser Thr Asn Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Leu Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Gly Ala Gly Arg Ala Phe Pro Gly Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
        115                 120                 125             


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
    130                 135                 140                 


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
145                 150                 155                 160 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
                165                 170                 175     


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Phe Ser Val Val 
            180                 185                 190         


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
        195                 200                 205             


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
    210                 215                 220                 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
225                 230                 235                 240 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
                245                 250                 255     


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            260                 265                 270         


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
        275                 280                 285             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    290                 295                 300                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
305                 310                 315                 320 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                325                 330                 335     


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            340                 345     


<210>  34
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR

<400>  34

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Ser Ser Thr Tyr 
            20                  25                  30          


Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ile Val 
        35                  40                  45              


Ala Val Ile Gly Trp Ser Gly Gly Arg Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ala Lys Asp Asn Ala Lys Asn Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Ser Glu Gln Ser Ser Ser Ser Glu Gly Gln Ala Tyr Gly 
            100                 105                 110         


Tyr Glu Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
        115                 120                 125             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    130                 135                 140                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
145                 150                 155                 160 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                165                 170                 175     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            180                 185                 190         


Leu Tyr Cys Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu 
        195                 200                 205             


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
    210                 215                 220                 


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
225                 230                 235                 240 


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
                245                 250                 255     


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
            260                 265                 270         


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
        275                 280                 285             


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    290                 295                 300                 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
305                 310                 315                 320 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                325                 330                 335     


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            340                 345                 350         


Pro Arg 
        


<210>  35
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR

<400>  35

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Ser Ser Thr Tyr 
            20                  25                  30          


Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ile Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Arg Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ala Lys Asp Ser Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Ser Glu Val Ser Ser Ser Ser Glu Gly Gln Tyr Gly Tyr 
            100                 105                 110         


Glu Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
                165                 170                 175     


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
            180                 185                 190         


Tyr Cys Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
        195                 200                 205             


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
    210                 215                 220                 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
225                 230                 235                 240 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
                245                 250                 255     


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            260                 265                 270         


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        275                 280                 285             


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    290                 295                 300                 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
305                 310                 315                 320 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                325                 330                 335     


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            340                 345                 350         


Arg 
    


<210>  36
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR

<400>  36

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Val Asp Ser 
    50                  55                  60                  


Val Leu Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Glu Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ser Thr Asp Val Leu Thr Ser Cys Arg Ser Asp Arg Tyr Leu Glu 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Gly Thr Thr Thr Pro 
        115                 120                 125             


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
    130                 135                 140                 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
145                 150                 155                 160 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
                165                 170                 175     


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
            180                 185                 190         


Cys Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
        195                 200                 205             


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
    210                 215                 220                 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
225                 230                 235                 240 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
                245                 250                 255     


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            260                 265                 270         


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        275                 280                 285             


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    290                 295                 300                 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
305                 310                 315                 320 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                325                 330                 335     


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            340                 345                 350         


<210>  37
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH

<400>  37

Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
1               5                   10                  15      


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210>  38
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 SP

<400>  38

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  39
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 hinge

<400>  39

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        35                  40                  45          


<210>  40
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 TM

<400>  40

Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
1               5                   10                  15      


Val Ile Thr Leu Tyr Cys 
            20          


<210>  41
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3zeta cytoplasmic domain

<400>  41

Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
1               5                   10                  15      


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            20                  25                  30          


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        35                  40                  45              


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    50                  55                  60                  


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
65                  70                  75                  80  


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                85                  90                  95      


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110     


<210>  42
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  41BB cytoplasmic domain

<400>  42

Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
1               5                   10                  15      


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
            20                  25                  30          


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
        35                  40                  45              


<210>  43
<211>  1038
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR

<400>  43
gaggtgcagc tggtggagtc tgggggaggc ttggtgcagg ctggggggtc tctgagactc       60

tcctgtgcag cctctggaag catcttcagt atcaatgcca tgggctggta ccgccaggct      120

ccagggaagc agcgcgagtt ggtcgcagct attactagtg gtggtagcac aaactatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaagaacac ggtgtatctg      240

caaatgaaca gcctgaaacc tgaggacaca gccgtctatt actgtaatgc aggagcgggg      300

cgggcctttc ccggggacta ctggggccag gggacccagg tcaccgtctc ctcaactaca      360

actccagcac ccagaccccc tacacctgct ccaactatcg caagtcagcc cctgtcactg      420

cgccctgaag cctgtcgccc tgctgccggg ggagctgtgc atactcgggg actggacttt      480

gcctgtgata tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca      540

ctggttatca ccctttactg caggttcagt gtcgtgaaga gaggccggaa gaagctgctg      600

tacatcttca agcagccttt catgaggccc gtgcagacta cccaggagga agatggatgc      660

agctgtagat tccctgaaga ggaggaagga ggctgtgagc tgagagtgaa gttctcccga      720

agcgcagatg ccccagccta tcagcaggga cagaatcagc tgtacaacga gctgaacctg      780

ggaagacggg aggaatacga tgtgctggac aaaaggcggg gcagagatcc tgagatgggc      840

ggcaaaccaa gacggaagaa cccccaggaa ggtctgtata atgagctgca gaaagacaag      900

atggctgagg cctactcaga aatcgggatg aagggcgaaa gaaggagagg aaaaggccac      960

gacggactgt accaggggct gagtacagca acaaaagaca cctatgacgc tctgcacatg     1020

caggctctgc caccaaga                                                   1038


<210>  44
<211>  1038
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR

<400>  44
caggtgcagc tcgtggagtc tgggggaggc ttggtgcagg ctggggggtc tctgagactc       60

tcctgtgcag cctctggaag catcttcagt atgaatgcca tgggctggta ccgccaggct      120

ccagggaagc agcgcgagtt ggtcgcagct attactagtg gtggtagcac aaactatgta      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaagaacac ggtgtatctg      240

caaatgaaca gcctgaaacc tgaggacaca gccgtctatt actgtaatgc aggagcgggg      300

cgggcctttc ccggggacta ctggggccag gggacccagg tcaccgtctc ctcaactaca      360

actccagcac ccagaccccc tacacctgct ccaactatcg caagtcagcc cctgtcactg      420

cgccctgaag cctgtcgccc tgctgccggg ggagctgtgc atactcgggg actggacttt      480

gcctgtgata tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca      540

ctggttatca ccctttactg caggttcagt gtcgtgaaga gaggccggaa gaagctgctg      600

tacatcttca agcagccttt catgaggccc gtgcagacta cccaggagga agatggatgc      660

agctgtagat tccctgaaga ggaggaagga ggctgtgagc tgagagtgaa gttctcccga      720

agcgcagatg ccccagccta tcagcaggga cagaatcagc tgtacaacga gctgaacctg      780

ggaagacggg aggaatacga tgtgctggac aaaaggcggg gcagagatcc tgagatgggc      840

ggcaaaccaa gacggaagaa cccccaggaa ggtctgtata atgagctgca gaaagacaag      900

atggctgagg cctactcaga aatcgggatg aagggcgaaa gaaggagagg aaaaggccac      960

gacggactgt accaggggct gagtacagca acaaaagaca cctatgacgc tctgcacatg     1020

caggctctgc caccaaga                                                   1038


<210>  45
<211>  1038
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR

<400>  45
gaggtgcagg tcgtggagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctcgaag catcttcagt atcaatgcca tgggctggta ccgccaggct      120

ccagggaaac agcgcgagtt ggtcgcagct attactagtg gtggtagcac aaactatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaagaacac ggtgtatctg      240

caaatgaaca gcctgaaacc tgaggacaca gccgtctatt actgtaattc aggagcgggg      300

cgggcctttc ccggggacta ctggggccag gggaccctgg tcaccgtctc ctcaactaca      360

actccagcac ccagaccccc tacacctgct ccaactatcg caagtcagcc cctgtcactg      420

cgccctgaag cctgtcgccc tgctgccggg ggagctgtgc atactcgggg actggacttt      480

gcctgtgata tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca      540

ctggttatca ccctttactg caggttcagt gtcgtgaaga gaggccggaa gaagctgctg      600

tacatcttca agcagccttt catgaggccc gtgcagacta cccaggagga agatggatgc      660

agctgtagat tccctgaaga ggaggaagga ggctgtgagc tgagagtgaa gttctcccga      720

agcgcagatg ccccagccta tcagcaggga cagaatcagc tgtacaacga gctgaacctg      780

ggaagacggg aggaatacga tgtgctggac aaaaggcggg gcagagatcc tgagatgggc      840

ggcaaaccaa gacggaagaa cccccaggaa ggtctgtata atgagctgca gaaagacaag      900

atggctgagg cctactcaga aatcgggatg aagggcgaaa gaaggagagg aaaaggccac      960

gacggactgt accaggggct gagtacagca acaaaagaca cctatgacgc tctgcacatg     1020

caggctctgc caccaaga                                                   1038


<210>  46
<211>  1053
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR

<400>  46
gaggtgcagc tcgtggagtc tgggggaggc tttgtgcagc cgggggggtc tctgagactc       60

tcctgtgcag cctctggatt cactttggat ggctatgccg tagcctggtt ccgccaggcc      120

ccagggaaag agcgcgaggg ggtctcatgt attagtagta gtgatggtag cacatactat      180

atagactccg tacagggccg attcaccatc acaagaaaca atgccaagaa cacggtgtat      240

ctgcaaatga acagcctgaa acctgaggac acggccgttt attactgtac gacagatgtc      300

cttacgagct gccggagcga caggtggctc gaagtttggg gccagggcac cctggtcact      360

gtctcctcaa ctacaactcc agcacccaga ccccctacac ctgctccaac tatcgcaagt      420

cagcccctgt cactgcgccc tgaagcctgt cgccctgctg ccgggggagc tgtgcatact      480

cggggactgg actttgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      540

gtccttctcc tgtcactggt tatcaccctt tactgcaggt tcagtgtcgt gaagagaggc      600

cggaagaagc tgctgtacat cttcaagcag cctttcatga ggcccgtgca gactacccag      660

gaggaagatg gatgcagctg tagattccct gaagaggagg aaggaggctg tgagctgaga      720

gtgaagttct cccgaagcgc agatgcccca gcctatcagc agggacagaa tcagctgtac      780

aacgagctga acctgggaag acgggaggaa tacgatgtgc tggacaaaag gcggggcaga      840

gatcctgaga tgggcggcaa accaagacgg aagaaccccc aggaaggtct gtataatgag      900

ctgcagaaag acaagatggc tgaggcctac tcagaaatcg ggatgaaggg cgaaagaagg      960

agaggaaaag gccacgacgg actgtaccag gggctgagta cagcaacaaa agacacctat     1020

gacgctctgc acatgcaggc tctgccacca aga                                  1053


<210>  47
<211>  1038
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR

<400>  47
caagtgcagc tggtggagac tgggggaggc ttggtgcagg ctggggggtc tctgagactc       60

tcctgtgcag cctctggaaa catcttcagt aacaatgcca tgggctggta ccgccaggct      120

ccagggaagc agcgcgagtt ggtcgcagct attactagtg atggtagcac aaactatgta      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaagaacac ggtgcttctg      240

caaatgaaca gcctgaaacc tgaggacaca gccgtctatt actgtaatgc aggagcgggg      300

cgggcctttc ccggggacta ctggggccag gggaccctgg tcactgtctc ctcaactaca      360

actccagcac ccagaccccc tacacctgct ccaactatcg caagtcagcc cctgtcactg      420

cgccctgaag cctgtcgccc tgctgccggg ggagctgtgc atactcgggg actggacttt      480

gcctgtgata tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca      540

ctggttatca ccctttactg caggttcagt gtcgtgaaga gaggccggaa gaagctgctg      600

tacatcttca agcagccttt catgaggccc gtgcagacta cccaggagga agatggatgc      660

agctgtagat tccctgaaga ggaggaagga ggctgtgagc tgagagtgaa gttctcccga      720

agcgcagatg ccccagccta tcagcaggga cagaatcagc tgtacaacga gctgaacctg      780

ggaagacggg aggaatacga tgtgctggac aaaaggcggg gcagagatcc tgagatgggc      840

ggcaaaccaa gacggaagaa cccccaggaa ggtctgtata atgagctgca gaaagacaag      900

atggctgagg cctactcaga aatcgggatg aagggcgaaa gaaggagagg aaaaggccac      960

gacggactgt accaggggct gagtacagca acaaaagaca cctatgacgc tctgcacatg     1020

caggctctgc caccaaga                                                   1038


<210>  48
<211>  1062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR

<400>  48
cagttgcagc tcgtggagtc tgggggagga ttggtgcagg ctgggggctc tctaagactc       60

tcctgtgcag tttctggacg cacctcaagt acttatgcca tggcctggtt ccgccaggct      120

ccaggcaagg agcgtgagat tgtagcagtt attggatgga gtggtggtag gacggcctat      180

gcagactccg tgaagggccg attcactatc gccaaagaca acgccaagaa cacggtgtct      240

ctgcaaatga acagtctgaa acctgaggac acgggcgttt attactgtgc agcagattct      300

gaacaaagta gctcgtccga aggccaggcg tatggctatg aggactgggg ccaggggacc      360

ctggtcactg tctcctcaac tacaactcca gcacccagac cccctacacc tgctccaact      420

atcgcaagtc agcccctgtc actgcgccct gaagcctgtc gccctgctgc cgggggagct      480

gtgcatactc ggggactgga ctttgcctgt gatatctaca tctgggcgcc cttggccggg      540

acttgtgggg tccttctcct gtcactggtt atcacccttt actgcaggtt cagtgtcgtg      600

aagagaggcc ggaagaagct gctgtacatc ttcaagcagc ctttcatgag gcccgtgcag      660

actacccagg aggaagatgg atgcagctgt agattccctg aagaggagga aggaggctgt      720

gagctgagag tgaagttctc ccgaagcgca gatgccccag cctatcagca gggacagaat      780

cagctgtaca acgagctgaa cctgggaaga cgggaggaat acgatgtgct ggacaaaagg      840

cggggcagag atcctgagat gggcggcaaa ccaagacgga agaaccccca ggaaggtctg      900

tataatgagc tgcagaaaga caagatggct gaggcctact cagaaatcgg gatgaagggc      960

gaaagaagga gaggaaaagg ccacgacgga ctgtaccagg ggctgagtac agcaacaaaa     1020

gacacctatg acgctctgca catgcaggct ctgccaccaa ga                        1062


<210>  49
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR

<400>  49
cagttgcagc tcgtggagtc tgggggaggc ttggtgcagc ctggggggtc cctgagactc       60

tcctgtgcag tttctggacg cacctcaagt acttatgcca tggcctggtt ccgccaggct      120

ccaggcaagg agcgtgagat tgtagcagtt attacatgga gtggtggtag gacggcctat      180

gcagactccg tgaagggccg attcactatc gccaaagaca gcgccaagaa cacggtgtat      240

ctgcaaatga acagcctgaa acctgaggat acggccgttt attactgtgc agcagattct      300

gaagtaagca gctcgtccga aggccagtat ggctatgagt cctggggcca ggggacccag      360

gtcaccgtct cctcaactac aactccagca cccagacccc ctacacctgc tccaactatc      420

gcaagtcagc ccctgtcact gcgccctgaa gcctgtcgcc ctgctgccgg gggagctgtg      480

catactcggg gactggactt tgcctgtgat atctacatct gggcgccctt ggccgggact      540

tgtggggtcc ttctcctgtc actggttatc accctttact gcaggttcag tgtcgtgaag      600

agaggccgga agaagctgct gtacatcttc aagcagcctt tcatgaggcc cgtgcagact      660

acccaggagg aagatggatg cagctgtaga ttccctgaag aggaggaagg aggctgtgag      720

ctgagagtga agttctcccg aagcgcagat gccccagcct atcagcaggg acagaatcag      780

ctgtacaacg agctgaacct gggaagacgg gaggaatacg atgtgctgga caaaaggcgg      840

ggcagagatc ctgagatggg cggcaaacca agacggaaga acccccagga aggtctgtat      900

aatgagctgc agaaagacaa gatggctgag gcctactcag aaatcgggat gaagggcgaa      960

agaaggagag gaaaaggcca cgacggactg taccaggggc tgagtacagc aacaaaagac     1020

acctatgacg ctctgcacat gcaggctctg ccaccaaga                            1059


<210>  50
<211>  1056
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR

<400>  50
caggtgcagc tggtggagtc tgggggaggc ttggtgcagc cgggggggtc tctgagactc       60

tcctgtgcag cctctggatt cactttggat tattatgccg taggctggtt ccgccaggcc      120

ccagggaagg agcgcgaggg ggtctcatgt attagtagta gtagtgatgg tagcacatac      180

tatgtagact ccgtgctggg ccgattcacc atctccagaa acaatgccga gaacacggtg      240

tatctgcaaa tgaacagcct gaaacctgag gacacggccg tttattactg ttcgacagat      300

gtccttacga gctgccggag cgacaggtat ctcgaagttt ggggccaggg caccctggtc      360

actgtctcag gcactacaac tccagcaccc agacccccta cacctgctcc aactatcgca      420

agtcagcccc tgtcactgcg ccctgaagcc tgtcgccctg ctgccggggg agctgtgcat      480

actcggggac tggactttgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt      540

ggggtccttc tcctgtcact ggttatcacc ctttactgca ggttcagtgt cgtgaagaga      600

ggccggaaga agctgctgta catcttcaag cagcctttca tgaggcccgt gcagactacc      660

caggaggaag atggatgcag ctgtagattc cctgaagagg aggaaggagg ctgtgagctg      720

agagtgaagt tctcccgaag cgcagatgcc ccagcctatc agcagggaca gaatcagctg      780

tacaacgagc tgaacctggg aagacgggag gaatacgatg tgctggacaa aaggcggggc      840

agagatcctg agatgggcgg caaaccaaga cggaagaacc cccaggaagg tctgtataat      900

gagctgcaga aagacaagat ggctgaggcc tactcagaaa tcgggatgaa gggcgaaaga      960

aggagaggaa aaggccacga cggactgtac caggggctga gtacagcaac aaaagacacc     1020

tatgacgctc tgcacatgca ggctctgcca ccaaga                               1056


<210>  51
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1Fc

<400>  51

Glu Leu Lys Thr Pro Gln Pro Gln Ser Gln Pro Glu Cys Arg Cys Pro 
1               5                   10                  15      


Lys Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Ile Phe 
            20                  25                  30          


Pro Pro Lys Pro Lys Asp Val Leu Ser Ile Ser Gly Arg Pro Glu Val 
        35                  40                  45              


Thr Cys Val Val Val Asp Val Gly Gln Glu Asp Pro Glu Val Ser Phe 
    50                  55                  60                  


Asn Trp Tyr Ile Asp Gly Ala Glu Val Arg Thr Ala Asn Thr Lys Pro 
65                  70                  75                  80  


Lys Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro 
                85                  90                  95      


Ile Arg His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Lys Val 
            100                 105                 110         


Asn Asn Lys Ala Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Ala 
        115                 120                 125             


Lys Gly Gln Thr Arg Glu Pro Gln Val Tyr Ala Leu Ala Pro His Arg 
    130                 135                 140                 


Glu Glu Leu Ala Lys Asp Thr Val Ser Val Thr Cys Leu Val Lys Asp 
145                 150                 155                 160 


Phe Tyr Pro Val Asp Ile Asn Ile Glu Trp Gln Arg Asn Gly Gln Pro 
                165                 170                 175     


Glu Ser Glu Gly Thr Tyr Ala Thr Thr Pro Pro Gln Leu Asp Asn Asp 
            180                 185                 190         


Gly Thr Tyr Phe Leu Tyr Ser Lys Leu Ser Val Gly Lys Asn Thr Trp 
        195                 200                 205             


Gln Arg Gly Glu Thr Phe Thr Cys Val Val Met His Glu Ala Leu Pro 
    210                 215                 220                 


Asn His Tyr Thr Gln Lys Ser Ile Thr Gln Ser Ser Gly Lys 
225                 230                 235             


<210>  52
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ARGXBBz

<400>  52
gttgtgaccc aggagccttc cctgacagtg tctccaggag ggacggtcac gctcacctgc       60

ggcctcaaat ctgggtctgt cacttccgat aacttcccca cttggtacca gcagacacca      120

ggccaggctc cccgattgct tatctacaac acaaacaccc gtcactctgg cgtccccgac      180

cgcttctccg gatccatcct gggcaacaaa gccgccctca ccatcacggg ggcccaggcc      240

gacgacgagg ccgaatattt ctgtgctctg ttcataagta atcctagtgt tgagttcggc      300

ggagggaccc aactgaccgt cctaggtggc agcaccagcg gctccggcaa gcctggatct      360

ggcgagggca gcaccaaggg cgaggtgcag ctcgtggagt ctgggggagg cttggtgcag      420

cctggggggt ctctgagact ctcctgtgca gcctctggat tcaccttcag tgtctactac      480

atgaactggg tccgccaggc tccagggaag gggctcgagt gggtctcaga tattaataat      540

gaaggtggta ctacatacta tgcagactcc gtgaagggcc gattcaccat ctccagagac      600

aactctaaga acagcctgta tctgcaaatg aacagcctgc gcgccgagga cacggccgtg      660

tactactgcg cgagagatgc cggatatagc aaccatgtac ccatctttga ttcttggggc      720

cagggcacta caactccagc acccagaccc cctacacctg ctccaactat cgcaagtcag      780

cccctgtcac tgcgccctga agcctgtcgc cctgctgccg ggggagctgt gcatactcgg      840

ggactggact ttgcctgtga tatctacatc tgggcgccct tggccgggac ttgtggggtc      900

cttctcctgt cactggttat caccctttac tgcaggttca gtgtcgtgaa gagaggccgg      960

aagaagctgc tgtacatctt caagcagcct ttcatgaggc ccgtgcagac tacccaggag     1020

gaagatggat gcagctgtag attccctgaa gaggaggaag gaggctgtga gctgagagtg     1080

aagttctccc gaagcgcaga tgccccagcc tatcagcagg gacagaatca gctgtacaac     1140

gagctgaacc tgggaagacg ggaggaatac gatgtgctgg acaaaaggcg gggcagagat     1200

cctgagatgg gcggcaaacc aagacggaag aacccccagg aaggtctgta taatgagctg     1260

cagaaagaca agatggctga ggcctactca gaaatcggga tgaagggcga aagaaggaga     1320

ggaaaaggcc acgacggact gtaccagggg ctgagtacag caacaaaaga cacctatgac     1380

gctctgcaca tgcaggctct gccaccaaga                                      1410


