                         SEQUENCE LISTING

<110>  INSTITUT PASTEUR
       THERAVECTYS
 
<120>  Boosting SARS-CoV-2 immunity with a lentiviral-based nasal 
       vaccine

<130>  B14699WO AD/DP/CG

<140>  PCT/XXXX
<141>  2022-01-17

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-Ancestral protein of SARS-CoV-2

<400>  1

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  2
<211>  3822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of the polynucleotide encoding S-Ancestral 
       protein of SARS-CoV-2

<400>  2
atgtttgttt ttcttgtttt attgccacta gtctctagtc agtgtgttaa tcttacaacc       60

agaactcaat taccccctgc atacactaat tctttcacac gtggtgttta ttaccctgac      120

aaagttttca gatcctcagt tttacattca actcaggact tgttcttacc tttcttttcc      180

aatgttactt ggttccatgc tatacatgtc tctgggacca atggtactaa gaggtttgat      240

aaccctgtcc taccatttaa tgatggtgtt tattttgctt ccactgagaa gtctaacata      300

ataagaggct ggatttttgg tactacttta gattcgaaga cccagtccct acttattgtt      360

aataacgcta ctaatgttgt tattaaagtc tgtgaatttc aattttgtaa tgatccattt      420

ttgggtgttt attaccacaa aaacaacaaa agttggatgg aaagtgagtt cagagtttat      480

tctagtgcga ataattgcac ttttgaatat gtctctcagc cttttcttat ggaccttgaa      540

ggaaaacagg gtaatttcaa aaatcttagg gaatttgtgt ttaagaatat tgatggttat      600

tttaaaatat attctaagca cacgcctatt aatttagtgc gtgatctccc tcagggtttt      660

tcggctttag aaccattggt agatttgcca ataggtatta acatcactag gtttcaaact      720

ttacttgctt tacatagaag ttatttgact cctggtgatt cttcttcagg ttggacagct      780

ggtgctgcag cttattatgt gggttatctt caacctagga cttttctatt aaaatataat      840

gaaaatggaa ccattacaga tgctgtagac tgtgcacttg accctctctc agaaacaaag      900

tgtacgttga aatccttcac tgtagaaaaa ggaatctatc aaacttctaa ctttagagtc      960

caaccaacag aatctattgt tagatttcct aatattacaa acttgtgccc ttttggtgaa     1020

gtttttaacg ccaccagatt tgcatctgtt tatgcttgga acaggaagag aatcagcaac     1080

tgtgttgctg attattctgt cctatataat tccgcatcat tttccacttt taagtgttat     1140

ggagtgtctc ctactaaatt aaatgatctc tgctttacta atgtctatgc agattcattt     1200

gtaattagag gtgatgaagt cagacaaatc gctccagggc aaactggaaa gattgctgat     1260

tataattata aattaccaga tgattttaca ggctgcgtta tagcttggaa ttctaacaat     1320

cttgattcta aggttggtgg taattataat tacctgtata gattgtttag gaagtctaat     1380

ctcaaacctt ttgagagaga tatttcaact gaaatctatc aggccggtag cacaccttgt     1440

aatggtgttg aaggttttaa ttgttacttt cctttacaat catatggttt ccaacccact     1500

aatggtgttg gttaccaacc atacagagta gtagtacttt cttttgaact tctacatgca     1560

ccagcaactg tttgtggacc taaaaagtct actaatttgg ttaaaaacaa atgtgtcaat     1620

ttcaacttca atggtttaac aggcacaggt gttcttactg agtctaacaa aaagtttctg     1680

cctttccaac aatttggcag agacattgct gacactactg atgctgtccg tgatccacag     1740

acacttgaga ttcttgacat tacaccatgt tcttttggtg gtgtcagtgt tataacacca     1800

ggaacaaata cttctaacca ggttgctgtt ctttatcagg atgttaactg cacagaagtc     1860

cctgttgcta ttcatgcaga tcaacttact cctacttggc gtgtttattc tacaggttct     1920

aatgtttttc aaacacgtgc aggctgttta ataggggctg aacatgtcaa caactcatat     1980

gagtgtgaca tacccattgg tgcaggtata tgcgctagtt atcagactca gactaattct     2040

cctcggcggg cacgtagtgt agctagtcaa tccatcattg cctacactat gtcacttggt     2100

gcagaaaatt cagttgctta ctctaataac tctattgcca tacccacaaa ttttactatt     2160

agtgttacca cagaaattct accagtgtct atgaccaaga catcagtaga ttgtacaatg     2220

tacatttgtg gtgattcaac tgaatgcagc aatcttttgt tgcaatatgg cagtttttgt     2280

acacaattaa accgtgcttt aactggaata gctgttgaac aagacaaaaa cacccaagaa     2340

gtttttgcac aagtcaaaca aatttacaaa acaccaccaa ttaaagattt tggtggtttt     2400

aatttttcac aaatattacc agatccatca aaaccaagca agaggtcatt tattgaagat     2460

ctacttttca acaaagtgac acttgcagat gctggcttca tcaaacaata tggtgattgc     2520

cttggtgata ttgctgctag agacctcatt tgtgcacaaa agtttaacgg ccttactgtt     2580

ttgccacctt tgctcacaga tgaaatgatt gctcaataca cttctgcact gttagcgggt     2640

acaatcactt ctggttggac ctttggtgca ggtgctgcat tacaaatacc atttgctatg     2700

caaatggctt ataggtttaa tggtattgga gttacacaga atgttctcta tgagaaccaa     2760

aaattgattg ccaaccaatt taatagtgct attggcaaaa ttcaagactc actttcttcc     2820

acagcaagtg cacttggaaa acttcaagat gtggtcaacc aaaatgcaca agctttaaac     2880

acgcttgtta aacaacttag ctccaatttt ggtgcaattt caagtgtttt aaatgatatc     2940

ctttcacgtc ttgacaaagt tgaggctgaa gtgcaaattg ataggttgat cacaggcaga     3000

cttcaaagtt tgcagacata tgtgactcaa caattaatta gagctgcaga aatcagagct     3060

tctgctaatc ttgctgctac taaaatgtca gagtgtgtac ttggacaatc aaaaagagtt     3120

gatttttgtg gaaagggcta tcatcttatg tccttccctc agtcagcacc tcatggtgta     3180

gtcttcttgc atgtgactta tgtccctgca caagaaaaga acttcacaac tgctcctgcc     3240

atttgtcatg atggaaaagc acactttcct cgtgaaggtg tctttgtttc aaatggcaca     3300

cactggtttg taacacaaag gaatttttat gaaccacaaa tcattactac agacaacaca     3360

tttgtgtctg gtaactgtga tgttgtaata ggaattgtca acaacacagt ttatgatcct     3420

ttgcaacctg aattagactc attcaaggag gagttagata aatattttaa gaatcataca     3480

tcaccagatg ttgatttagg tgacatctct ggcattaatg cttcagttgt aaacattcaa     3540

aaagaaattg accgcctcaa tgaggttgcc aagaatttaa atgaatctct catcgatctc     3600

caagaacttg gaaagtatga gcagtatata aaatggccat ggtacatttg gctaggtttt     3660

atagctggct tgattgccat agtaatggtg acaattatgc tttgctgtat gaccagttgc     3720

tgtagttgtc tcaagggctg ttgttcttgt ggatcctgct gcaaatttga tgaagacgac     3780

tctgagccag tgctcaaagg agtcaaatta cattacacat aa                        3822


<210>  3
<211>  3825
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of the polynucleotide encoding S-D614G-2P 
       protein of SARS-CoV-2

<400>  3
atgttcgtgt ttctggtgct gctgccactg gtgtccagtc agtgcgtgaa cctgaccaca       60

cgaacacagc tgccaccagc ctacaccaat agcttcaccc gcggagtgta ctaccccgac      120

aaggtgttcc gcagcagcgt gctgcatagc acccaggatc tgtttctgcc cttcttcagc      180

aacgtgacct ggttccacgc catccacgtg tccggcacca atggcaccaa gcgcttcgat      240

aatcccgtgc tgcccttcaa cgatggcgtg tactttgcca gcaccgagaa gtccaatatc      300

atccgcggct ggatcttcgg caccacactg gatagcaaga cccagagcct gctgatcgtg      360

aacaacgcca ccaacgtggt catcaaagtg tgcgagttcc agttctgcaa cgaccccttc      420

ctgggcgtct actaccacaa gaacaacaag agctggatgg aaagcgagtt ccgcgtgtac      480

agcagcgcca acaactgcac cttcgagtac gtgtcccagc cattcctgat ggacctggaa      540

ggcaagcagg gcaacttcaa gaacctgcgc gagttcgtgt tcaagaacat cgacggctac      600

ttcaaaatct acagcaagca caccccaatc aacctcgtgc gcgatctgcc acagggattc      660

agtgctctgg aacccctggt ggatctgccc atcggcatca acattacccg ctttcagaca      720

ctgctggccc tgcaccgcag ttacttgaca ccaggcgata gcagcagtgg atggacagct      780

ggtgccgccg cttactacgt tggatatctg cagccacgca cctttctgct gaagtacaac      840

gagaacggca ccatcaccga cgccgtggat tgtgctctcg atcccctgag cgagacaaag      900

tgcaccctga agtccttcac cgtcgagaag ggcatctacc agaccagcaa tttccgcgtg      960

cagcccaccg agagcatcgt gcgcttcccc aatatcacca atctgtgccc cttcggcgag     1020

gtgttcaatg ccacacgctt tgcctccgtg tacgcctgga atcgcaagcg cattagcaac     1080

tgcgtggccg actactccgt gctgtacaat agcgccagct tcagcacctt caagtgctac     1140

ggcgtgtcac ccaccaagct gaacgacctg tgcttcacca atgtgtacgc cgacagcttc     1200

gtgatccgcg gagatgaagt gcgacagatt gccccaggcc agaccggcaa gatcgccgac     1260

tacaattaca agctgcccga cgacttcacc ggctgcgtga tcgcctggaa cagcaacaac     1320

ctggattcca aagtcggcgg caactacaac tacctgtacc gcctgttccg caagagcaat     1380

ctgaagccct tcgagcgcga catcagcacc gaaatctacc aggccggaag caccccatgc     1440

aacggcgtgg aaggcttcaa ctgctacttc ccactgcagt cctacggatt tcagcccaca     1500

aatggcgtgg gctaccagcc atatcgagtg gtggtgctga gcttcgaact gctgcatgct     1560

ccagctaccg tgtgcggccc caagaagagt accaacctgg tcaagaacaa atgcgtgaac     1620

ttcaacttca acggcctgac cggaaccggc gtgctgaccg agagtaacaa gaagttcctg     1680

ccattccagc agtttggccg cgacattgcc gatacaaccg atgccgttcg cgatccccag     1740

accttggaga tcctggatat taccccatgc tccttcggcg gcgtgtccgt gattacacca     1800

ggcaccaata ccagcaacca ggtggccgtt ctgtaccagg gcgtgaattg cacagaggtg     1860

cccgtggcca ttcacgccga tcaattgaca ccaacatggc gcgtgtactc caccggcagc     1920

aatgtgtttc aaacccgcgc tggatgcctg attggagccg agcacgtgaa caatagctac     1980

gagtgcgata tccccatcgg agccggaatc tgcgcctcct atcagaccca gaccaatagt     2040

ccacgacgag cccgaagtgt ggccagccag agcatcattg cctataccat gagcctgggc     2100

gccgagaata gcgtggccta ctccaacaac agcattgcta tccccaccaa cttcaccatc     2160

agcgtgacca ccgagatcct gccagtgtcc atgaccaaga ccagcgtgga ctgcaccatg     2220

tacatctgcg gagatagcac cgagtgcagc aacctgctgc tgcagtacgg aagtttctgc     2280

acccagctga atcgcgccct gacaggcatt gccgtggaac aggataagaa cacccaagag     2340

gtgttcgccc aagtgaagca aatctacaag accccaccaa tcaaggattt cggcggcttc     2400

aatttcagcc agattctgcc cgatccaagc aagcccagca agcgcagctt catcgaggac     2460

ctgctgttca acaaagtgac actggccgac gccggattca tcaagcagta tggcgattgc     2520

ctgggcgata ttgccgcacg cgatctgatt tgcgcccaga agtttaacgg actgaccgtc     2580

ctgccaccac tgctgacaga tgagatgatc gcccagtaca caagtgccct gctggccgga     2640

accattacca gcggatggac atttggagcc ggtgccgctc tgcagattcc cttcgctatg     2700

cagatggcct accgcttcaa tggcattggc gtgacccaga atgtgctgta cgagaaccag     2760

aagctgatcg ccaaccagtt caacagcgcc atcggcaaga ttcaggacag cctgagtagt     2820

accgccagcg ctctgggaaa gctgcaggat gtggtcaacc agaacgctca ggccctgaac     2880

accctggtta agcagctgag cagcaacttc ggcgccatca gtagcgtgct gaacgatatc     2940

ctgagccgcc tggatccgcc ggaagccgag gtgcagatcg atcgcctgat taccggacgc     3000

ctgcagtccc tgcagaccta tgtgacacag cagctgatcc gagccgccga gattcgagct     3060

agtgctaatc tggccgccac caagatgagc gaatgtgtgc tgggacagag caagcgcgtg     3120

gacttttgcg gcaagggata ccacctgatg agcttcccac agagtgctcc acacggcgtg     3180

gtgtttctgc atgtgaccta cgtgcccgct caagagaaga atttcaccac cgctccagcc     3240

atctgccacg acggaaaggc ccattttcca cgcgagggcg tgttcgttag caacggcact     3300

cattggttcg tcacccagcg caacttctac gagccccaga tcatcaccac cgacaacacc     3360

ttcgtcagcg gcaactgcga cgtcgtgatc ggcattgtga acaacaccgt gtacgatcca     3420

ctgcagcccg agctggacag cttcaaagag gaactggaca agtactttaa gaaccacaca     3480

agccccgacg tggacctggg agacattagc ggaatcaacg ccagcgtggt caacatccag     3540

aaagagattg accgcctgaa cgaggtggcc aagaatctga acgagagcct gatcgacctg     3600

caagaactgg gcaaatacga gcagtacatt aagtggccct ggtacatctg gctgggcttc     3660

attgccggac tgattgccat cgtgatggtc accattatgc tgtgctgcat gaccagttgc     3720

tgcagctgcc tgaagggatg ctgcagttgc ggaagctgct gcaagttcga cgaggatgat     3780

agcgagccag tgctgaaggg cgtcaagctg cactacacct gataa                     3825


<210>  4
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-D614G-2P protein of SARS-CoV-2

<400>  4

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  5
<211>  3813
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of the polynucleotide encoding S-Alpha-2P 
       protein of SARS-CoV-2

<400>  5
atgttcgtgt ttctggtgct gctgccactg gtgtccagtc agtgcgtgaa cctgaccaca       60

cgaacacagc tgccaccagc ctacaccaat agcttcaccc gcggagtgta ctaccccgac      120

aaggtgttcc gcagcagcgt gctgcatagc acccaggatc tgtttctgcc cttcttcagc      180

aacgtgacct ggttccacgc catctccggc accaatggca ccaagcgctt cgataatccc      240

gtgctgccct tcaacgatgg cgtgtacttt gccagcaccg agaagtccaa tatcatccgc      300

ggctggatct tcggcaccac actggatagc aagacccaga gcctgctgat cgtgaacaac      360

gccaccaacg tggtcatcaa agtgtgcgag ttccagttct gcaacgaccc cttcctgggc      420

gtctaccaca agaacaacaa gagctggatg gaaagcgagt tccgcgtgta cagcagcgcc      480

aacaactgca ccttcgagta cgtgtcccag ccattcctga tggacctgga aggcaagcag      540

ggcaacttca agaacctgcg cgagttcgtg ttcaagaaca tcgacggcta cttcaaaatc      600

tacagcaagc acaccccaat caacctcgtg cgcgatctgc cacagggatt cagtgctctg      660

gaacccctgg tggatctgcc catcggcatc aacattaccc gctttcagac actgctggcc      720

ctgcaccgca gttacttgac accaggcgat agcagcagtg gatggacagc tggtgccgcc      780

gcttactacg ttggatatct gcagccacgc acctttctgc tgaagtacaa cgagaacggc      840

accatcaccg acgccgtgga ttgtgctctc gatcccctga gcgagacaaa gtgcaccctg      900

aagtccttca ccgtcgagaa gggcatctac cagaccagca atttccgcgt gcagcccacc      960

gagagcatcg tgcgcttccc caatatcacc aatctgtgcc ccttcggcga ggtgttcaat     1020

gccacacgct ttgcctccgt gtacgcctgg aatcgcaagc gcattagcaa ctgcgtggcc     1080

gactactccg tgctgtacaa tagcgccagc ttcagcacct tcaagtgcta cggcgtgtca     1140

cccaccaagc tgaacgacct gtgcttcacc aatgtgtacg ccgacagctt cgtgatccgc     1200

ggagatgaag tgcgacagat tgccccaggc cagaccggca agatcgccga ctacaattac     1260

aagctgcccg acgacttcac cggctgcgtg atcgcctgga acagcaacaa cctggattcc     1320

aaagtcggcg gcaactacaa ctacctgtac cgcctgttcc gcaagagcaa tctgaagccc     1380

ttcgagcgcg acatcagcac cgaaatctac caggccggaa gcaccccatg caacggcgtg     1440

gaaggcttca actgctactt cccactgcag tcctacggat ttcagcccac atatggcgtg     1500

ggctaccagc catatcgagt ggtggtgctg agcttcgaac tgctgcatgc tccagctacc     1560

gtgtgcggcc ccaagaagag taccaacctg gtcaagaaca aatgcgtgaa cttcaacttc     1620

aacggcctga ccggaaccgg cgtgctgacc gagagtaaca agaagttcct gccattccag     1680

cagtttggcc gcgacattga cgatacaacc gatgccgttc gcgatcccca gaccttggag     1740

atcctggata ttaccccatg ctccttcggc ggcgtgtccg tgattacacc aggcaccaat     1800

accagcaacc aggtggccgt tctgtaccag ggcgtgaatt gcacagaggt gcccgtggcc     1860

attcacgccg atcaattgac accaacatgg cgcgtgtact ccaccggcag caatgtgttt     1920

caaacccgcg ctggatgcct gattggagcc gagcacgtga acaatagcta cgagtgcgat     1980

atccccatcg gagccggaat ctgcgcctcc tatcagaccc agaccaatag tcaccgacga     2040

gcccgaagtg tggccagcca gagcatcatt gcctatacca tgagcctggg cgccgagaat     2100

agcgtggcct actccaacaa cagcattgct atccccatca acttcaccat cagcgtgacc     2160

accgagatcc tgccagtgtc catgaccaag accagcgtgg actgcaccat gtacatctgc     2220

ggagatagca ccgagtgcag caacctgctg ctgcagtacg gaagtttctg cacccagctg     2280

aatcgcgccc tgacaggcat tgccgtggaa caggataaga acacccaaga ggtgttcgcc     2340

caagtgaagc aaatctacaa gaccccacca atcaaggatt tcggcggctt caatttcagc     2400

cagattctgc ccgatccaag caagcccagc aagcgcagct tcatcgagga cctgctgttc     2460

aacaaagtga cactggccga cgccggattc atcaagcagt atggcgattg cctgggcgat     2520

attgccgcac gcgatctgat ttgcgcccag aagtttaacg gactgaccgt cctgccacca     2580

ctgctgacag atgagatgat cgcccagtac acaagtgccc tgctggccgg aaccattacc     2640

agcggatgga catttggagc cggtgccgct ctgcagattc ccttcgctat gcagatggcc     2700

taccgcttca atggcattgg cgtgacccag aatgtgctgt acgagaacca gaagctgatc     2760

gccaaccagt tcaacagcgc catcggcaag attcaggaca gcctgagtag taccgccagc     2820

gctctgggaa agctgcagga tgtggtcaac cagaacgctc aggccctgaa caccctggtt     2880

aagcagctga gcagcaactt cggcgccatc agtagcgtgc tgaacgatat cctggcccgc     2940

ctggatccgc cggaagccga ggtgcagatc gatcgcctga ttaccggacg cctgcagtcc     3000

ctgcagacct atgtgacaca gcagctgatc cgagccgccg agattcgagc tagtgctaat     3060

ctggccgcca ccaagatgag cgaatgtgtg ctgggacaga gcaagcgcgt ggacttttgc     3120

ggcaagggat accacctgat gagcttccca cagagtgctc cacacggcgt ggtgtttctg     3180

catgtgacct acgtgcccgc tcaagagaag aatttcacca ccgctccagc catctgccac     3240

gacggaaagg cccattttcc acgcgagggc gtgttcgtta gcaacggcac tcattggttc     3300

gtcacccagc gcaacttcta cgagccccag atcatcacca cccacaacac cttcgtcagc     3360

ggcaactgcg acgtcgtgat cggcattgtg aacaacaccg tgtacgatcc actgcagccc     3420

gagctggaca gcttcaaaga ggaactggac aagtacttta agaaccacac aagccccgac     3480

gtggacctgg gagacattag cggaatcaac gccagcgtgg tcaacatcca gaaagagatt     3540

gaccgcctga acgaggtggc caagaatctg aacgagagcc tgatcgacct gcaagaactg     3600

ggcaaatacg agcagtacat taagtggccc tggtacatct ggctgggctt cattgccgga     3660

ctgattgcca tcgtgatggt caccattatg ctgtgctgca tgaccagttg ctgcagctgc     3720

ctgaagggat gctgcagttg cggaagctgc tgcaagttcg acgaggatga tagcgagcca     3780

gtgctgaagg gcgtcaagct gcactacacc tga                                  3813


<210>  6
<211>  1270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-Alpha-2P protein of SARS-CoV-2

<400>  6

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro 
65                  70                  75                  80  


Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser 
                85                  90                  95      


Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr 
            100                 105                 110         


Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val 
        115                 120                 125             


Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr His Lys 
    130                 135                 140                 


Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala 
145                 150                 155                 160 


Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu 
                165                 170                 175     


Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys 
            180                 185                 190         


Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn 
        195                 200                 205             


Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val 
    210                 215                 220                 


Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
        355                 360                 365             


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
465                 470                 475                 480 


Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Asp Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Asn Ser His Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Ile Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Leu Ala Arg Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr His  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1250                 1255                 1260             


Gly Val  Lys Leu His Tyr Thr  
    1265                 1270 


<210>  7
<211>  3813
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of the polynucleotide encoding S-Beta protein
       of SARS-CoV-2

<400>  7
atgttcgtgt ttctggtgct gctgccactg gtgtccagtc agtgcgtgaa cttcaccaca       60

cgaacacagc tgccaccagc ctacaccaat agcttcaccc gcggagtgta ctaccccgac      120

aaggtgttcc gcagcagcgt gctgcatagc acccaggatc tgtttctgcc cttcttcagc      180

aacgtgacct ggttccacgc catccacgtg tccggcacca atggcaccaa gcgcttcgct      240

aatcccgtgc tgcccttcaa cgatggcgtg tactttgcca gcaccgagaa gtccaatatc      300

atccgcggct ggatcttcgg caccacactg gatagcaaga cccagagcct gctgatcgtg      360

aacaacgcca ccaacgtggt catcaaagtg tgcgagttcc agttctgcaa cgaccccttc      420

ctgggcgtct actaccacaa gaacaacaag agctggatgg aaagcgagtt ccgcgtgtac      480

agcagcgcca acaactgcac cttcgagtac gtgtcccagc cattcctgat ggacctggaa      540

ggcaagcagg gcaacttcaa gaacctgcgc gagttcgtgt tcaagaacat cgacggctac      600

ttcaaaatct acagcaagca caccccaatc aacctcgtgc gcggcctgcc acagggattc      660

agtgctctgg aacccctggt ggatctgccc atcggcatca acattacccg ctttcagaca      720

ctgcaccgca gttacttgac accaggcgat agcagcagtg gatggacagc tggtgccgcc      780

gcttactacg ttggatatct gcagccacgc acctttctgc tgaagtacaa cgagaacggc      840

accatcaccg acgccgtgga ttgtgctctc gatcccctga gcgagacaaa gtgcaccctg      900

aagtccttca ccgtcgagaa gggcatctac cagaccagca atttccgcgt gcagcccacc      960

gagagcatcg tgcgcttccc caatatcacc aatctgtgcc ccttcggcga ggtgttcaat     1020

gccacacgct ttgcctccgt gtacgcctgg aatcgcaagc gcattagcaa ctgcgtggcc     1080

gactactccg tgctgtacaa tagcgccagc ttcagcacct tcaagtgcta cggcgtgtca     1140

cccaccaagc tgaacgacct gtgcttcacc aatgtgtacg ccgacagctt cgtgatccgc     1200

ggagatgaag tgcgacagat tgccccaggc cagaccggca acatcgccga ctacaattac     1260

aagctgcccg acgacttcac cggctgcgtg atcgcctgga acagcaacaa cctggattcc     1320

aaagtcggcg gcaactacaa ctacctgtac cgcctgttcc gcaagagcaa tctgaagccc     1380

ttcgagcgcg acatcagcac cgaaatctac caggccggaa gcaccccatg caacggcgtg     1440

aaaggcttca actgctactt cccactgcag tcctacggat ttcagcccac atatggcgtg     1500

ggctaccagc catatcgagt ggtggtgctg agcttcgaac tgctgcatgc tccagctacc     1560

gtgtgcggcc ccaagaagag taccaacctg gtcaagaaca aatgcgtgaa cttcaacttc     1620

aacggcctga ccggaaccgg cgtgctgacc gagagtaaca agaagttcct gccattccag     1680

cagtttggcc gcgacattgc cgatacaacc gatgccgttc gcgatcccca gaccttggag     1740

atcctggata ttaccccatg ctccttcggc ggcgtgtccg tgattacacc aggcaccaat     1800

accagcaacc aggtggccgt tctgtaccag ggcgtgaatt gcacagaggt gcccgtggcc     1860

attcacgccg atcaattgac accaacatgg cgcgtgtact ccaccggcag caatgtgttt     1920

caaacccgcg ctggatgcct gattggagcc gagcacgtga acaatagcta cgagtgcgat     1980

atccccatcg gagccggaat ctgcgcctcc tatcagaccc agaccaatag tccacgacga     2040

gcccgaagtg tggccagcca gagcatcatt gcctatacca tgagcctggg cgtggagaat     2100

agcgtggcct actccaacaa cagcattgct atccccacca acttcaccat cagcgtgacc     2160

accgagatcc tgccagtgtc catgaccaag accagcgtgg actgcaccat gtacatctgc     2220

ggagatagca ccgagtgcag caacctgctg ctgcagtacg gaagtttctg cacccagctg     2280

aatcgcgccc tgacaggcat tgccgtggaa caggataaga acacccaaga ggtgttcgcc     2340

caagtgaagc aaatctacaa gaccccacca atcaaggatt tcggcggctt caatttcagc     2400

cagattctgc ccgatccaag caagcccagc aagcgcagct tcatcgagga cctgctgttc     2460

aacaaagtga cactggccga cgccggattc atcaagcagt atggcgattg cctgggcgat     2520

attgccgcac gcgatctgat ttgcgcccag aagtttaacg gactgaccgt cctgccacca     2580

ctgctgacag atgagatgat cgcccagtac acaagtgccc tgctggccgg aaccattacc     2640

agcggatgga catttggagc cggtgccgct ctgcagattc ccttcgctat gcagatggcc     2700

taccgcttca atggcattgg cgtgacccag aatgtgctgt acgagaacca gaagctgatc     2760

gccaaccagt tcaacagcgc catcggcaag attcaggaca gcctgagtag taccgccagc     2820

gctctgggaa agctgcagga tgtggtcaac cagaacgctc aggccctgaa caccctggtt     2880

aagcagctga gcagcaactt cggcgccatc agtagcgtgc tgaacgatat cctgagccgc     2940

ctggataagg tggaagccga ggtgcagatc gatcgcctga ttaccggacg cctgcagtcc     3000

ctgcagacct atgtgacaca gcagctgatc cgagccgccg agattcgagc tagtgctaat     3060

ctggccgcca ccaagatgag cgaatgtgtg ctgggacaga gcaagcgcgt ggacttttgc     3120

ggcaagggat accacctgat gagcttccca cagagtgctc cacacggcgt ggtgtttctg     3180

catgtgacct acgtgcccgc tcaagagaag aatttcacca ccgctccagc catctgccac     3240

gacggaaagg cccattttcc acgcgagggc gtgttcgtta gcaacggcac tcattggttc     3300

gtcacccagc gcaacttcta cgagccccag atcatcacca ccgacaacac cttcgtcagc     3360

ggcaactgcg acgtcgtgat cggcattgtg aacaacaccg tgtacgatcc actgcagccc     3420

gagctggaca gcttcaaaga ggaactggac aagtacttta agaaccacac aagccccgac     3480

gtggacctgg gagacattag cggaatcaac gccagcgtgg tcaacatcca gaaagagatt     3540

gaccgcctga acgaggtggc caagaatctg aacgagagcc tgatcgacct gcaagaactg     3600

ggcaaatacg agcagtacat taagtggccc tggtacatct ggctgggctt cattgccgga     3660

ctgattgcca tcgtgatggt caccattatg ctgtgctgca tgaccagttg ctgcagctgc     3720

ctgaagggat gctgcagttg cggaagctgc tgcaagttcg acgaggatga tagcgagcca     3780

gtgctgaagg gcgtcaagct gcactacacc tga                                  3813


<210>  8
<211>  1270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-Beta protein of SARS-CoV-2

<400>  8

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Ala 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
        355                 360                 365             


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
465                 470                 475                 480 


Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1250                 1255                 1260             


Gly Val  Lys Leu His Tyr Thr  
    1265                 1270 


<210>  9
<211>  3813
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of the polynucleotide encoding S-Beta-2P 
       protein of SARS-CoV-2

<400>  9
atgttcgtgt ttctggtgct gctgccactg gtgtccagtc agtgcgtgaa cttcaccaca       60

cgaacacagc tgccaccagc ctacaccaat agcttcaccc gcggagtgta ctaccccgac      120

aaggtgttcc gcagcagcgt gctgcatagc acccaggatc tgtttctgcc cttcttcagc      180

aacgtgacct ggttccacgc catccacgtg tccggcacca atggcaccaa gcgcttcgct      240

aatcccgtgc tgcccttcaa cgatggcgtg tactttgcca gcaccgagaa gtccaatatc      300

atccgcggct ggatcttcgg caccacactg gatagcaaga cccagagcct gctgatcgtg      360

aacaacgcca ccaacgtggt catcaaagtg tgcgagttcc agttctgcaa cgaccccttc      420

ctgggcgtct actaccacaa gaacaacaag agctggatgg aaagcgagtt ccgcgtgtac      480

agcagcgcca acaactgcac cttcgagtac gtgtcccagc cattcctgat ggacctggaa      540

ggcaagcagg gcaacttcaa gaacctgcgc gagttcgtgt tcaagaacat cgacggctac      600

ttcaaaatct acagcaagca caccccaatc aacctcgtgc gcggcctgcc acagggattc      660

agtgctctgg aacccctggt ggatctgccc atcggcatca acattacccg ctttcagaca      720

ctgcaccgca gttacttgac accaggcgat agcagcagtg gatggacagc tggtgccgcc      780

gcttactacg ttggatatct gcagccacgc acctttctgc tgaagtacaa cgagaacggc      840

accatcaccg acgccgtgga ttgtgctctc gatcccctga gcgagacaaa gtgcaccctg      900

aagtccttca ccgtcgagaa gggcatctac cagaccagca atttccgcgt gcagcccacc      960

gagagcatcg tgcgcttccc caatatcacc aatctgtgcc ccttcggcga ggtgttcaat     1020

gccacacgct ttgcctccgt gtacgcctgg aatcgcaagc gcattagcaa ctgcgtggcc     1080

gactactccg tgctgtacaa tagcgccagc ttcagcacct tcaagtgcta cggcgtgtca     1140

cccaccaagc tgaacgacct gtgcttcacc aatgtgtacg ccgacagctt cgtgatccgc     1200

ggagatgaag tgcgacagat tgccccaggc cagaccggca acatcgccga ctacaattac     1260

aagctgcccg acgacttcac cggctgcgtg atcgcctgga acagcaacaa cctggattcc     1320

aaagtcggcg gcaactacaa ctacctgtac cgcctgttcc gcaagagcaa tctgaagccc     1380

ttcgagcgcg acatcagcac cgaaatctac caggccggaa gcaccccatg caacggcgtg     1440

aaaggcttca actgctactt cccactgcag tcctacggat ttcagcccac atatggcgtg     1500

ggctaccagc catatcgagt ggtggtgctg agcttcgaac tgctgcatgc tccagctacc     1560

gtgtgcggcc ccaagaagag taccaacctg gtcaagaaca aatgcgtgaa cttcaacttc     1620

aacggcctga ccggaaccgg cgtgctgacc gagagtaaca agaagttcct gccattccag     1680

cagtttggcc gcgacattgc cgatacaacc gatgccgttc gcgatcccca gaccttggag     1740

atcctggata ttaccccatg ctccttcggc ggcgtgtccg tgattacacc aggcaccaat     1800

accagcaacc aggtggccgt tctgtaccag ggcgtgaatt gcacagaggt gcccgtggcc     1860

attcacgccg atcaattgac accaacatgg cgcgtgtact ccaccggcag caatgtgttt     1920

caaacccgcg ctggatgcct gattggagcc gagcacgtga acaatagcta cgagtgcgat     1980

atccccatcg gagccggaat ctgcgcctcc tatcagaccc agaccaatag tccacgacga     2040

gcccgaagtg tggccagcca gagcatcatt gcctatacca tgagcctggg cgtggagaat     2100

agcgtggcct actccaacaa cagcattgct atccccacca acttcaccat cagcgtgacc     2160

accgagatcc tgccagtgtc catgaccaag accagcgtgg actgcaccat gtacatctgc     2220

ggagatagca ccgagtgcag caacctgctg ctgcagtacg gaagtttctg cacccagctg     2280

aatcgcgccc tgacaggcat tgccgtggaa caggataaga acacccaaga ggtgttcgcc     2340

caagtgaagc aaatctacaa gaccccacca atcaaggatt tcggcggctt caatttcagc     2400

cagattctgc ccgatccaag caagcccagc aagcgcagct tcatcgagga cctgctgttc     2460

aacaaagtga cactggccga cgccggattc atcaagcagt atggcgattg cctgggcgat     2520

attgccgcac gcgatctgat ttgcgcccag aagtttaacg gactgaccgt cctgccacca     2580

ctgctgacag atgagatgat cgcccagtac acaagtgccc tgctggccgg aaccattacc     2640

agcggatgga catttggagc cggtgccgct ctgcagattc ccttcgctat gcagatggcc     2700

taccgcttca atggcattgg cgtgacccag aatgtgctgt acgagaacca gaagctgatc     2760

gccaaccagt tcaacagcgc catcggcaag attcaggaca gcctgagtag taccgccagc     2820

gctctgggaa agctgcagga tgtggtcaac cagaacgctc aggccctgaa caccctggtt     2880

aagcagctga gcagcaactt cggcgccatc agtagcgtgc tgaacgatat cctgagccgc     2940

ctggatccgc cggaagccga ggtgcagatc gatcgcctga ttaccggacg cctgcagtcc     3000

ctgcagacct atgtgacaca gcagctgatc cgagccgccg agattcgagc tagtgctaat     3060

ctggccgcca ccaagatgag cgaatgtgtg ctgggacaga gcaagcgcgt ggacttttgc     3120

ggcaagggat accacctgat gagcttccca cagagtgctc cacacggcgt ggtgtttctg     3180

catgtgacct acgtgcccgc tcaagagaag aatttcacca ccgctccagc catctgccac     3240

gacggaaagg cccattttcc acgcgagggc gtgttcgtta gcaacggcac tcattggttc     3300

gtcacccagc gcaacttcta cgagccccag atcatcacca ccgacaacac cttcgtcagc     3360

ggcaactgcg acgtcgtgat cggcattgtg aacaacaccg tgtacgatcc actgcagccc     3420

gagctggaca gcttcaaaga ggaactggac aagtacttta agaaccacac aagccccgac     3480

gtggacctgg gagacattag cggaatcaac gccagcgtgg tcaacatcca gaaagagatt     3540

gaccgcctga acgaggtggc caagaatctg aacgagagcc tgatcgacct gcaagaactg     3600

ggcaaatacg agcagtacat taagtggccc tggtacatct ggctgggctt cattgccgga     3660

ctgattgcca tcgtgatggt caccattatg ctgtgctgca tgaccagttg ctgcagctgc     3720

ctgaagggat gctgcagttg cggaagctgc tgcaagttcg acgaggatga tagcgagcca     3780

gtgctgaagg gcgtcaagct gcactacacc tga                                  3813


<210>  10
<211>  1270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-Beta-2P protein of SARS-CoV-2

<400>  10

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Ala 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
        355                 360                 365             


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
465                 470                 475                 480 


Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1250                 1255                 1260             


Gly Val  Lys Leu His Tyr Thr  
    1265                 1270 


<210>  11
<211>  3822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of the polynucleotide encoding S-Gamma-2P 
       protein of SARS-CoV-2

<400>  11
atgttcgtgt ttctggtgct gctgccactg gtgtccagtc agtgcgtgaa cttcaccaac       60

cgaacacagc tgccatccgc ctacaccaat agcttcaccc gcggagtgta ctaccccgac      120

aaggtgttcc gcagcagcgt gctgcatagc acccaggatc tgtttctgcc cttcttcagc      180

aacgtgacct ggttccacgc catccacgtg tccggcacca atggcaccaa gcgcttcgat      240

aatcccgtgc tgcccttcaa cgatggcgtg tactttgcca gcaccgagaa gtccaatatc      300

atccgcggct ggatcttcgg caccacactg gatagcaaga cccagagcct gctgatcgtg      360

aacaacgcca ccaacgtggt catcaaagtg tgcgagttcc agttctgcaa ctaccccttc      420

ctgggcgtct actaccacaa gaacaacaag agctggatgg aaagcgagtt ccgcgtgtac      480

agcagcgcca acaactgcac cttcgagtac gtgtcccagc cattcctgat ggacctggaa      540

ggcaagcagg gcaacttcaa gaacctgtcc gagttcgtgt tcaagaacat cgacggctac      600

ttcaaaatct acagcaagca caccccaatc aacctcgtgc gcgatctgcc acagggattc      660

agtgctctgg aacccctggt ggatctgccc atcggcatca acattacccg ctttcagaca      720

ctgctggccc tgcaccgcag ttacttgaca ccaggcgata gcagcagtgg atggacagct      780

ggtgccgccg cttactacgt tggatatctg cagccacgca cctttctgct gaagtacaac      840

gagaacggca ccatcaccga cgccgtggat tgtgctctcg atcccctgag cgagacaaag      900

tgcaccctga agtccttcac cgtcgagaag ggcatctacc agaccagcaa tttccgcgtg      960

cagcccaccg agagcatcgt gcgcttcccc aatatcacca atctgtgccc cttcggcgag     1020

gtgttcaatg ccacacgctt tgcctccgtg tacgcctgga atcgcaagcg cattagcaac     1080

tgcgtggccg actactccgt gctgtacaat agcgccagct tcagcacctt caagtgctac     1140

ggcgtgtcac ccaccaagct gaacgacctg tgcttcacca atgtgtacgc cgacagcttc     1200

gtgatccgcg gagatgaagt gcgacagatt gccccaggcc agaccggcac catcgccgac     1260

tacaattaca agctgcccga cgacttcacc ggctgcgtga tcgcctggaa cagcaacaac     1320

ctggattcca aagtcggcgg caactacaac tacctgtacc gcctgttccg caagagcaat     1380

ctgaagccct tcgagcgcga catcagcacc gaaatctacc aggccggaag caccccatgc     1440

aacggcgtga aaggcttcaa ctgctacttc ccactgcagt cctacggatt tcagcccaca     1500

tatggcgtgg gctaccagcc atatcgagtg gtggtgctga gcttcgaact gctgcatgct     1560

ccagctaccg tgtgcggccc caagaagagt accaacctgg tcaagaacaa atgcgtgaac     1620

ttcaacttca acggcctgac cggaaccggc gtgctgaccg agagtaacaa gaagttcctg     1680

ccattccagc agtttggccg cgacattgcc gatacaaccg atgccgttcg cgatccccag     1740

accttggaga tcctggatat taccccatgc tccttcggcg gcgtgtccgt gattacacca     1800

ggcaccaata ccagcaacca ggtggccgtt ctgtaccagg gcgtgaattg cacagaggtg     1860

cccgtggcca ttcacgccga tcaattgaca ccaacatggc gcgtgtactc caccggcagc     1920

aatgtgtttc aaacccgcgc tggatgcctg attggagccg agtacgtgaa caatagctac     1980

gagtgcgata tccccatcgg agccggaatc tgcgcctcct atcagaccca gaccaatagt     2040

ccacgacgag cccgaagtgt ggccagccag agcatcattg cctataccat gagcctgggc     2100

gccgagaata gcgtggccta ctccaacaac agcattgcta tccccaccaa cttcaccatc     2160

agcgtgacca ccgagatcct gccagtgtcc atgaccaaga ccagcgtgga ctgcaccatg     2220

tacatctgcg gagatagcac cgagtgcagc aacctgctgc tgcagtacgg aagtttctgc     2280

acccagctga atcgcgccct gacaggcatt gccgtggaac aggataagaa cacccaagag     2340

gtgttcgccc aagtgaagca aatctacaag accccaccaa tcaaggattt cggcggcttc     2400

aatttcagcc agattctgcc cgatccaagc aagcccagca agcgcagctt catcgaggac     2460

ctgctgttca acaaagtgac actggccgac gccggattca tcaagcagta tggcgattgc     2520

ctgggcgata ttgccgcacg cgatctgatt tgcgcccaga agtttaacgg actgaccgtc     2580

ctgccaccac tgctgacaga tgagatgatc gcccagtaca caagtgccct gctggccgga     2640

accattacca gcggatggac atttggagcc ggtgccgctc tgcagattcc cttcgctatg     2700

cagatggcct accgcttcaa tggcattggc gtgacccaga atgtgctgta cgagaaccag     2760

aagctgatcg ccaaccagtt caacagcgcc atcggcaaga ttcaggacag cctgagtagt     2820

accgccagcg ctctgggaaa gctgcaggat gtggtcaacc agaacgctca ggccctgaac     2880

accctggtta agcagctgag cagcaacttc ggcgccatca gtagcgtgct gaacgatatc     2940

ctgagccgcc tggatccgcc ggaagccgag gtgcagatcg atcgcctgat taccggacgc     3000

ctgcagtccc tgcagaccta tgtgacacag cagctgatcc gagccgccga gattcgagct     3060

agtgctaatc tggccgccat caagatgagc gaatgtgtgc tgggacagag caagcgcgtg     3120

gacttttgcg gcaagggata ccacctgatg agcttcccac agagtgctcc acacggcgtg     3180

gtgtttctgc atgtgaccta cgtgcccgct caagagaaga atttcaccac cgctccagcc     3240

atctgccacg acggaaaggc ccattttcca cgcgagggcg tgttcgttag caacggcact     3300

cattggttcg tcacccagcg caacttctac gagccccaga tcatcaccac cgacaacacc     3360

ttcgtcagcg gcaactgcga cgtcgtgatc ggcattgtga acaacaccgt gtacgatcca     3420

ctgcagcccg agctggacag cttcaaagag gaactggaca agtactttaa gaaccacaca     3480

agccccgacg tggacctggg agacattagc ggaatcaacg ccagcgtggt caacatccag     3540

aaagagattg accgcctgaa cgaggtggcc aagaatctga acgagagcct gatcgacctg     3600

caagaactgg gcaaatacga gcagtacatt aagtggccct ggtacatctg gctgggcttc     3660

attgccggac tgattgccat cgtgatggtc accattatgc tgtgctgcat gaccagttgc     3720

tgcagctgcc tgaagggatg ctgcagttgc ggaagctgct gcaagttcga cgaggatgat     3780

agcgagccag tgctgaaggg cgtcaagctg cactacacct ga                        3822


<210>  12
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-Gamma-2P protein of SARS-CoV-2

<400>  12

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Phe Thr Asn Arg Thr Gln Leu Pro Ser Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Tyr Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Ser Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Thr Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu Tyr Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Ile Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  13
<211>  3816
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of the polynucleotide encoding S-Delta-2P 
       protein of SARS-CoV-2

<400>  13
atgttcgtgt ttctggtgct gctgccactg gtgtccagtc agtgcgtgaa cctgaggaca       60

cgaacacagc tgccaccagc ctacaccaat agcttcaccc gcggagtgta ctaccccgac      120

aaggtgttcc gcagcagcgt gctgcatagc acccaggatc tgtttctgcc cttcttcagc      180

aacgtgacct ggttccacgc catccacgtg tccggcacca atggcaccaa gcgcttcgat      240

aatcccgtgc tgcccttcaa cgatggcgtg tactttgcca gcaccgagaa gtccaatatc      300

atccgcggct ggatcttcgg caccacactg gatagcaaga cccagagcct gctgatcgtg      360

aacaacgcca ccaacgtggt catcaaagtg tgcgagttcc agttctgcaa cgaccccttc      420

ctggacgtct actaccacaa gaacaacaag agctggatgg aaagcggcgt gtacagcagc      480

gccaacaact gcaccttcga gtacgtgtcc cagccattcc tgatggacct ggaaggcaag      540

cagggcaact tcaagaacct gcgcgagttc gtgttcaaga acatcgacgg ctacttcaaa      600

atctacagca agcacacccc aatcaacctc gtgcgcgatc tgccacaggg attcagtgct      660

ctggaacccc tggtggatct gcccatcggc atcaacatta cccgctttca gacactgctg      720

gccctgcacc gcagttactt gacaccaggc gatagcagca gtggatggac agctggtgcc      780

gccgcttact acgttggata tctgcagcca cgcacctttc tgctgaagta caacgagaac      840

ggcaccatca ccgacgccgt ggattgtgct ctcgatcccc tgagcgagac aaagtgcacc      900

ctgaagtcct tcaccgtcga gaagggcatc taccagacca gcaatttccg cgtgcagccc      960

accgagagca tcgtgcgctt ccccaatatc accaatctgt gccccttcgg cgaggtgttc     1020

aatgccacac gctttgcctc cgtgtacgcc tggaatcgca agcgcattag caactgcgtg     1080

gccgactact ccgtgctgta caatagcgcc agcttcagca ccttcaagtg ctacggcgtg     1140

tcacccacca agctgaacga cctgtgcttc accaatgtgt acgccgacag cttcgtgatc     1200

cgcggagatg aagtgcgaca gattgcccca ggccagaccg gcaagatcgc cgactacaat     1260

tacaagctgc ccgacgactt caccggctgc gtgatcgcct ggaacagcaa caacctggat     1320

tccaaagtcg gcggcaacta caactacaga taccgcctgt tccgcaagag caatctgaag     1380

cccttcgagc gcgacatcag caccgaaatc taccaggccg gaagcaagcc atgcaacggc     1440

gtggaaggct tcaactgcta cttcccactg cagtcctacg gatttcagcc cacaaatggc     1500

gtgggctacc agccatatcg agtggtggtg ctgagcttcg aactgctgca tgctccagct     1560

accgtgtgcg gccccaagaa gagtaccaac ctggtcaaga acaaatgcgt gaacttcaac     1620

ttcaacggcc tgaccggaac cggcgtgctg accgagagta acaagaagtt cctgccattc     1680

cagcagtttg gccgcgacat tgccgataca accgatgccg ttcgcgatcc ccagaccttg     1740

gagatcctgg atattacccc atgctccttc ggcggcgtgt ccgtgattac accaggcacc     1800

aataccagca accaggtggc cgttctgtac cagggcgtga attgcacaga ggtgcccgtg     1860

gccattcacg ccgatcaatt gacaccaaca tggcgcgtgt actccaccgg cagcaatgtg     1920

tttcaaaccc gcgctggatg cctgattgga gccgagcacg tgaacaatag ctacgagtgc     1980

gatatcccca tcggagccgg aatctgcgcc tcctatcaga cccagaccaa tagtagacga     2040

cgagcccgaa gtgtggccag ccagagcatc attgcctata ccatgagcct gggcgccgag     2100

aatagcgtgg cctactccaa caacagcatt gctatcccca ccaacttcac catcagcgtg     2160

accaccgaga tcctgccagt gtccatgacc aagaccagcg tggactgcac catgtacatc     2220

tgcggagata gcaccgagtg cagcaacctg ctgctgcagt acggaagttt ctgcacccag     2280

ctgaatcgcg ccctgacagg cattgccgtg gaacaggata agaacaccca agaggtgttc     2340

gcccaagtga agcaaatcta caagacccca ccaatcaagg atttcggcgg cttcaatttc     2400

agccagattc tgcccgatcc aagcaagccc agcaagcgca gcttcatcga ggacctgctg     2460

ttcaacaaag tgacactggc cgacgccgga ttcatcaagc agtatggcga ttgcctgggc     2520

gatattgccg cacgcgatct gatttgcgcc cagaagttta acggactgac cgtcctgcca     2580

ccactgctga cagatgagat gatcgcccag tacacaagtg ccctgctggc cggaaccatt     2640

accagcggat ggacatttgg agccggtgcc gctctgcaga ttcccttcgc tatgcagatg     2700

gcctaccgct tcaatggcat tggcgtgacc cagaatgtgc tgtacgagaa ccagaagctg     2760

atcgccaacc agttcaacag cgccatcggc aagattcagg acagcctgag tagtaccgcc     2820

agcgctctgg gaaagctgca gaacgtggtc aaccagaacg ctcaggccct gaacaccctg     2880

gttaagcagc tgagcagcaa cttcggcgcc atcagtagcg tgctgaacga tatcctgagc     2940

cgcctggatc cgccggaagc cgaggtgcag atcgatcgcc tgattaccgg acgcctgcag     3000

tccctgcaga cctatgtgac acagcagctg atccgagccg ccgagattcg agctagtgct     3060

aatctggccg ccaccaagat gagcgaatgt gtgctgggac agagcaagcg cgtggacttt     3120

tgcggcaagg gataccacct gatgagcttc ccacagagtg ctccacacgg cgtggtgttt     3180

ctgcatgtga cctacgtgcc cgctcaagag aagaatttca ccaccgctcc agccatctgc     3240

cacgacggaa aggcccattt tccacgcgag ggcgtgttcg ttagcaacgg cactcattgg     3300

ttcgtcaccc agcgcaactt ctacgagccc cagatcatca ccaccgacaa caccttcgtc     3360

agcggcaact gcgacgtcgt gatcggcatt gtgaacaaca ccgtgtacga tccactgcag     3420

cccgagctgg acagcttcaa agaggaactg gacaagtact ttaagaacca cacaagcccc     3480

gacgtggacc tgggagacat tagcggaatc aacgccagcg tggtcaacat ccagaaagag     3540

attgaccgcc tgaacgaggt ggccaagaat ctgaacgaga gcctgatcga cctgcaagaa     3600

ctgggcaaat acgagcagta cattaagtgg ccctggtaca tctggctggg cttcattgcc     3660

ggactgattg ccatcgtgat ggtcaccatt atgctgtgct gcatgaccag ttgctgcagc     3720

tgcctgaagg gatgctgcag ttgcggaagc tgctgcaagt tcgacgagga tgatagcgag     3780

ccagtgctga agggcgtcaa gctgcactac acctga                               3816


<210>  14
<211>  1271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-Delta-2P protein of SARS-CoV-2

<400>  14

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Arg Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Asp Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Gly Val Tyr Ser Ser 
145                 150                 155                 160 


Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp 
                165                 170                 175     


Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe 
            180                 185                 190         


Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile 
        195                 200                 205             


Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu 
    210                 215                 220                 


Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu 
225                 230                 235                 240 


Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp 
                245                 250                 255     


Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr 
            260                 265                 270         


Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp 
        275                 280                 285             


Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe 
    290                 295                 300                 


Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro 
305                 310                 315                 320 


Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe 
                325                 330                 335     


Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn 
            340                 345                 350         


Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn 
        355                 360                 365             


Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys 
    370                 375                 380                 


Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile 
385                 390                 395                 400 


Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile 
                405                 410                 415     


Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile 
            420                 425                 430         


Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn 
        435                 440                 445             


Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg 
    450                 455                 460                 


Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Lys Pro Cys Asn Gly 
465                 470                 475                 480 


Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln 
                485                 490                 495     


Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser 
            500                 505                 510         


Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser 
        515                 520                 525             


Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu 
    530                 535                 540                 


Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe 
545                 550                 555                 560 


Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp 
                565                 570                 575     


Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly 
            580                 585                 590         


Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val 
        595                 600                 605             


Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala 
    610                 615                 620                 


Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val 
625                 630                 635                 640 


Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn 
                645                 650                 655     


Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr 
            660                 665                 670         


Gln Thr Gln Thr Asn Ser Arg Arg Arg Ala Arg Ser Val Ala Ser Gln 
        675                 680                 685             


Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala 
    690                 695                 700                 


Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val 
705                 710                 715                 720 


Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys 
                725                 730                 735     


Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu 
            740                 745                 750         


Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile 
        755                 760                 765             


Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys 
    770                 775                 780                 


Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe 
785                 790                 795                 800 


Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile 
                805                 810                 815     


Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile 
            820                 825                 830         


Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile 
        835                 840                 845             


Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr 
    850                 855                 860                 


Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile 
865                 870                 875                 880 


Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe 
                885                 890                 895     


Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn 
            900                 905                 910         


Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala 
        915                 920                 925             


Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly 
    930                 935                 940                 


Lys Leu Gln Asn Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu 
945                 950                 955                 960 


Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn 
                965                 970                 975     


Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp 
            980                 985                 990         


Arg Leu Ile Thr Gly Arg Leu Gln  Ser Leu Gln Thr Tyr  Val Thr Gln 
        995                 1000                 1005             


Gln Leu  Ile Arg Ala Ala Glu  Ile Arg Ala Ser Ala  Asn Leu Ala 
    1010                 1015                 1020             


Ala Thr  Lys Met Ser Glu Cys  Val Leu Gly Gln Ser  Lys Arg Val 
    1025                 1030                 1035             


Asp Phe  Cys Gly Lys Gly Tyr  His Leu Met Ser Phe  Pro Gln Ser 
    1040                 1045                 1050             


Ala Pro  His Gly Val Val Phe  Leu His Val Thr Tyr  Val Pro Ala 
    1055                 1060                 1065             


Gln Glu  Lys Asn Phe Thr Thr  Ala Pro Ala Ile Cys  His Asp Gly 
    1070                 1075                 1080             


Lys Ala  His Phe Pro Arg Glu  Gly Val Phe Val Ser  Asn Gly Thr 
    1085                 1090                 1095             


His Trp  Phe Val Thr Gln Arg  Asn Phe Tyr Glu Pro  Gln Ile Ile 
    1100                 1105                 1110             


Thr Thr  Asp Asn Thr Phe Val  Ser Gly Asn Cys Asp  Val Val Ile 
    1115                 1120                 1125             


Gly Ile  Val Asn Asn Thr Val  Tyr Asp Pro Leu Gln  Pro Glu Leu 
    1130                 1135                 1140             


Asp Ser  Phe Lys Glu Glu Leu  Asp Lys Tyr Phe Lys  Asn His Thr 
    1145                 1150                 1155             


Ser Pro  Asp Val Asp Leu Gly  Asp Ile Ser Gly Ile  Asn Ala Ser 
    1160                 1165                 1170             


Val Val  Asn Ile Gln Lys Glu  Ile Asp Arg Leu Asn  Glu Val Ala 
    1175                 1180                 1185             


Lys Asn  Leu Asn Glu Ser Leu  Ile Asp Leu Gln Glu  Leu Gly Lys 
    1190                 1195                 1200             


Tyr Glu  Gln Tyr Ile Lys Trp  Pro Trp Tyr Ile Trp  Leu Gly Phe 
    1205                 1210                 1215             


Ile Ala  Gly Leu Ile Ala Ile  Val Met Val Thr Ile  Met Leu Cys 
    1220                 1225                 1230             


Cys Met  Thr Ser Cys Cys Ser  Cys Leu Lys Gly Cys  Cys Ser Cys 
    1235                 1240                 1245             


Gly Ser  Cys Cys Lys Phe Asp  Glu Asp Asp Ser Glu  Pro Val Leu 
    1250                 1255                 1260             


Lys Gly  Val Lys Leu His Tyr  Thr 
    1265                 1270     


<210>  15
<211>  3813
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of the polynucleotide encoding S-Omicron 
       protein of SARS-CoV-2

<400>  15
atgttcgtgt ttctggtgct gctgcctctg gtgtccagcc agtgtgtgaa cctgaccacc       60

agaacacagc tgcctccagc ctacaccaac agctttacca gaggcgtgta ctaccccgac      120

aaggtgttca gatccagcgt gctgcactct acccaggacc tgttcctgcc tttcttcagc      180

aacgtgacct ggttccacgt gatcagcggc accaatggca ccaagagatt cgacaacccc      240

gtgctgccct tcaacgacgg ggtgtacttt gccagcatcg agaagtccaa catcatccgc      300

ggctggatct tcggcaccac actggatagc aagacccaga gcctgctgat cgtgaacaac      360

gccaccaacg tggtcatcaa agtgtgcgag ttccagttct gcaacgaccc attcctggac      420

cacaagaaca acaagagctg gatggaaagc gagttccggg tgtacagcag cgccaacaac      480

tgcaccttcg agtacgtgtc ccagcctttc ctgatggacc tggaaggcaa gcagggcaac      540

ttcaagaacc tgcgcgagtt cgtgttcaag aacatcgacg gctacttcaa gatctacagc      600

aagcacaccc ctatcatcgt gcgcgagcct gaggatctgc ctcagggctt ttctgccctg      660

gaacctctgg tggatctgcc catcggcatc aacatcaccc ggtttcagac actgctggcc      720

ctgcacagaa gctacctgac acctggcgat agcagcagcg gatggacagc tggtgccgcc      780

gcttactatg tgggctacct gcagcctaga accttcctgc tgaagtacaa cgagaacggc      840

accatcaccg acgccgtgga ttgtgctctt gatcccctga gcgagacaaa gtgcaccctg      900

aagtccttca ccgtggaaaa gggcatctac cagaccagca acttccgggt gcagcccacc      960

gaatccatcg tgcggttccc caatatcacc aatctgtgcc ccttcgatga ggtgttcaat     1020

gccaccagat tcgccagcgt gtacgcctgg aaccggaaga gaatcagcaa ctgcgtggcc     1080

gactactccg tgctgtacaa tctggcccca ttcttcacct tcaagtgcta cggcgtgtcc     1140

cctaccaagc tgaacgacct gtgcttcacc aatgtgtacg ccgacagctt cgtgatccgg     1200

ggagatgaag tgcggcagat tgcccctgga cagaccggca atatcgccga ctacaactac     1260

aagctgcccg acgacttcac cggctgtgtg atcgcctgga atagcaacaa gctggacagc     1320

aaggtgtccg gcaactacaa ttacctgtac cggctgttcc ggaagtccaa tctgaagccc     1380

ttcgagcggg acatcagcac cgagatctat caggccggca acaagccctg taatggcgtg     1440

gccggcttca actgctactt cccactgcgg agctacagct tcagacccac atacggcgtt     1500

ggccaccagc cttacagagt ggtggtgctg tccttcgagc tgctgcatgc tcctgccaca     1560

gtgtgcggcc ctaagaaaag caccaacctc gtgaagaaca aatgcgtgaa cttcaacttc     1620

aacggcctga aaggcaccgg cgtgctgacc gagagcaaca agaagttcct gccattccag     1680

cagttcggcc gggacattgc cgataccaca gatgctgtca gagatcccca gacactggaa     1740

atcctggaca tcaccccttg cagcttcggc ggagtgtctg tgatcacccc tggcaccaac     1800

accagcaatc aggtggcagt gctgtaccag ggcgtgaact gtacagaggt gccagtggcc     1860

attcacgccg atcagctgac ccctacttgg cgggtgtact ccacaggcag caatgtgttc     1920

cagaccagag ccggctgtct gattggcgcc gagtatgtga acaacagcta cgagtgcgac     1980

atccccatcg gagccggcat ctgtgccagc taccagacac agaccaagag ccacagacgg     2040

gctagaagcg tggccagcca gagcatcatt gcctacacaa tgtctctggg cgccgagaac     2100

agcgtggcct acagcaacaa ctctatcgct atccccacca acttcaccat cagcgtgacc     2160

accgagattc tgcccgtgtc catgaccaag accagcgtgg actgcaccat gtacatctgc     2220

ggcgattcca ccgagtgctc caacctgctg ctgcagtacg gcagcttctg cacccagctg     2280

aagagagccc tgacagggat tgccgtggaa caggacaaga acacccaaga ggtgttcgcc     2340

caagtgaagc agatctacaa gacccctcct atcaagtact tcggcgggtt caacttctcc     2400

cagatcctgc cagatcctag caagcccagc aagcggagct tcatcgagga cctgctgttc     2460

aacaaagtga cactggccga cgccggcttt atcaagcagt atggcgattg cctgggcgac     2520

attgcagcca gggatctgat ttgcgcccag aagttcaagg gcctgacagt gctgcctcct     2580

ctgctgacag atgagatgat cgcccagtac acaagcgccc tgctggccgg cacaatcacc     2640

tctggatgga catttggagc cggcgctgcc ctgcagatcc catttgctat gcagatggcc     2700

taccggttca acggcatcgg agtgacccag aatgtgctgt acgagaacca gaagctgatc     2760

gccaaccagt tcaacagcgc catcggcaag atccaggaca gcctgagcag cacagcctct     2820

gctctgggca agctgcagga cgtggtcaac cataatgccc aggcactgaa caccctggtc     2880

aagcagctgt cctccaagtt cggcgccatc tctagcgtgc tgaatgacat cttctccagg     2940

ctggacaagg tggaagccga ggtgcagatc gacagactga tcaccggaag gctgcagtcc     3000

ctgcagacct acgttaccca gcagctgatt agagccgccg agatcagagc cagcgccaat     3060

ctggctgcca caaagatgag cgagtgtgtg ctgggccaga gcaagagagt ggacttttgc     3120

ggcaagggct accacctgat gagcttccct cagtctgctc ctcacggcgt ggtgtttctg     3180

cacgtgacat acgtgcccgc tcaagagaag aatttcacca ccgctccagc catctgccac     3240

gacggcaaag cccactttcc tagagaaggc gtgttcgtgt ccaacggcac ccattggttc     3300

gtgacccagc ggaacttcta cgagccccag atcatcacca ccgacaacac cttcgtgtct     3360

ggcaactgcg acgtcgtgat cggcattgtg aacaataccg tgtacgaccc tctgcagccc     3420

gagctggact ccttcaaaga ggaactggat aagtacttta agaaccacac aagccccgac     3480

gtggacctgg gcgatatcag cggaatcaat gccagcgtcg tgaacatcca gaaagagatc     3540

gaccggctga acgaggtggc caagaatctg aacgagagcc tgatcgacct gcaagaactg     3600

gggaagtacg agcagtacat caagtggcct tggtacatct ggctgggctt tatcgccgga     3660

ctgattgcca tcgtgatggt cacaatcatg ctgtgctgta tgaccagctg ctgtagctgc     3720

ctgaagggct gttgtagctg tggctcctgc tgcaagttcg acgaggacga ttctgagccc     3780

gtgctgaaag gcgtgaagct gcactacaca tga                                  3813


<210>  16
<211>  1270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-Omicron protein of SARS-CoV-2

<400>  16

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Val Ile Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro 
65                  70                  75                  80  


Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Ile Glu Lys Ser 
                85                  90                  95      


Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr 
            100                 105                 110         


Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val 
        115                 120                 125             


Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Asp His Lys Asn Asn 
    130                 135                 140                 


Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn 
145                 150                 155                 160 


Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly 
                165                 170                 175     


Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile 
            180                 185                 190         


Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Ile Val Arg 
        195                 200                 205             


Glu Pro Glu Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val 
    210                 215                 220                 


Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Asp 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Leu 
        355                 360                 365             


Ala Pro Phe Phe Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Lys Leu Asp Ser Lys Val Ser Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Asn Lys Pro Cys Asn Gly Val 
465                 470                 475                 480 


Ala Gly Phe Asn Cys Tyr Phe Pro Leu Arg Ser Tyr Ser Phe Arg Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly His Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Lys 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu Tyr Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Lys Ser His Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Lys Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Tyr Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Lys Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn His Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Lys Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Phe Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1250                 1255                 1260             


Gly Val  Lys Leu His Tyr Thr  
    1265                 1270 


<210>  17
<211>  3813
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of the polynucleotide encoding S-Omicron-2P 
       protein of SARS-CoV-2

<400>  17
atgttcgtgt ttctggtgct gctgcctctg gtgtccagcc agtgtgtgaa cctgaccacc       60

agaacacagc tgcctccagc ctacaccaac agctttacca gaggcgtgta ctaccccgac      120

aaggtgttca gatccagcgt gctgcactct acccaggacc tgttcctgcc tttcttcagc      180

aacgtgacct ggttccacgt gatcagcggc accaatggca ccaagagatt cgacaacccc      240

gtgctgccct tcaacgacgg ggtgtacttt gccagcatcg agaagtccaa catcatccgc      300

ggctggatct tcggcaccac actggatagc aagacccaga gcctgctgat cgtgaacaac      360

gccaccaacg tggtcatcaa agtgtgcgag ttccagttct gcaacgaccc attcctggac      420

cacaagaaca acaagagctg gatggaaagc gagttccggg tgtacagcag cgccaacaac      480

tgcaccttcg agtacgtgtc ccagcctttc ctgatggacc tggaaggcaa gcagggcaac      540

ttcaagaacc tgcgcgagtt cgtgttcaag aacatcgacg gctacttcaa gatctacagc      600

aagcacaccc ctatcatcgt gcgcgagcct gaggatctgc ctcagggctt ttctgccctg      660

gaacctctgg tggatctgcc catcggcatc aacatcaccc ggtttcagac actgctggcc      720

ctgcacagaa gctacctgac acctggcgat agcagcagcg gatggacagc tggtgccgcc      780

gcttactatg tgggctacct gcagcctaga accttcctgc tgaagtacaa cgagaacggc      840

accatcaccg acgccgtgga ttgtgctctt gatcccctga gcgagacaaa gtgcaccctg      900

aagtccttca ccgtggaaaa gggcatctac cagaccagca acttccgggt gcagcccacc      960

gaatccatcg tgcggttccc caatatcacc aatctgtgcc ccttcgatga ggtgttcaat     1020

gccaccagat tcgccagcgt gtacgcctgg aaccggaaga gaatcagcaa ctgcgtggcc     1080

gactactccg tgctgtacaa tctggcccca ttcttcacct tcaagtgcta cggcgtgtcc     1140

cctaccaagc tgaacgacct gtgcttcacc aatgtgtacg ccgacagctt cgtgatccgg     1200

ggagatgaag tgcggcagat tgcccctgga cagaccggca atatcgccga ctacaactac     1260

aagctgcccg acgacttcac cggctgtgtg atcgcctgga atagcaacaa gctggacagc     1320

aaggtgtccg gcaactacaa ttacctgtac cggctgttcc ggaagtccaa tctgaagccc     1380

ttcgagcggg acatcagcac cgagatctat caggccggca acaagccctg taatggcgtg     1440

gccggcttca actgctactt cccactgcgg agctacagct tcagacccac atacggcgtt     1500

ggccaccagc cttacagagt ggtggtgctg tccttcgagc tgctgcatgc tcctgccaca     1560

gtgtgcggcc ctaagaaaag caccaacctc gtgaagaaca aatgcgtgaa cttcaacttc     1620

aacggcctga aaggcaccgg cgtgctgacc gagagcaaca agaagttcct gccattccag     1680

cagttcggcc gggacattgc cgataccaca gatgctgtca gagatcccca gacactggaa     1740

atcctggaca tcaccccttg cagcttcggc ggagtgtctg tgatcacccc tggcaccaac     1800

accagcaatc aggtggcagt gctgtaccag ggcgtgaact gtacagaggt gccagtggcc     1860

attcacgccg atcagctgac ccctacttgg cgggtgtact ccacaggcag caatgtgttc     1920

cagaccagag ccggctgtct gattggcgcc gagtatgtga acaacagcta cgagtgcgac     1980

atccccatcg gagccggcat ctgtgccagc taccagacac agaccaagag ccacagacgg     2040

gctagaagcg tggccagcca gagcatcatt gcctacacaa tgtctctggg cgccgagaac     2100

agcgtggcct acagcaacaa ctctatcgct atccccacca acttcaccat cagcgtgacc     2160

accgagattc tgcccgtgtc catgaccaag accagcgtgg actgcaccat gtacatctgc     2220

ggcgattcca ccgagtgctc caacctgctg ctgcagtacg gcagcttctg cacccagctg     2280

aagagagccc tgacagggat tgccgtggaa caggacaaga acacccaaga ggtgttcgcc     2340

caagtgaagc agatctacaa gacccctcct atcaagtact tcggcgggtt caacttctcc     2400

cagatcctgc cagatcctag caagcccagc aagcggagct tcatcgagga cctgctgttc     2460

aacaaagtga cactggccga cgccggcttt atcaagcagt atggcgattg cctgggcgac     2520

attgcagcca gggatctgat ttgcgcccag aagttcaagg gcctgacagt gctgcctcct     2580

ctgctgacag atgagatgat cgcccagtac acaagcgccc tgctggccgg cacaatcacc     2640

tctggatgga catttggagc cggcgctgcc ctgcagatcc catttgctat gcagatggcc     2700

taccggttca acggcatcgg agtgacccag aatgtgctgt acgagaacca gaagctgatc     2760

gccaaccagt tcaacagcgc catcggcaag atccaggaca gcctgagcag cacagcctct     2820

gctctgggca agctgcagga cgtggtcaac cataatgccc aggcactgaa caccctggtc     2880

aagcagctgt cctccaagtt cggcgccatc tctagcgtgc tgaatgacat cttctccagg     2940

ctggacccgc cggaagccga ggtgcagatc gacagactga tcaccggaag gctgcagtcc     3000

ctgcagacct acgttaccca gcagctgatt agagccgccg agatcagagc cagcgccaat     3060

ctggctgcca caaagatgag cgagtgtgtg ctgggccaga gcaagagagt ggacttttgc     3120

ggcaagggct accacctgat gagcttccct cagtctgctc ctcacggcgt ggtgtttctg     3180

cacgtgacat acgtgcccgc tcaagagaag aatttcacca ccgctccagc catctgccac     3240

gacggcaaag cccactttcc tagagaaggc gtgttcgtgt ccaacggcac ccattggttc     3300

gtgacccagc ggaacttcta cgagccccag atcatcacca ccgacaacac cttcgtgtct     3360

ggcaactgcg acgtcgtgat cggcattgtg aacaataccg tgtacgaccc tctgcagccc     3420

gagctggact ccttcaaaga ggaactggat aagtacttta agaaccacac aagccccgac     3480

gtggacctgg gcgatatcag cggaatcaat gccagcgtcg tgaacatcca gaaagagatc     3540

gaccggctga acgaggtggc caagaatctg aacgagagcc tgatcgacct gcaagaactg     3600

gggaagtacg agcagtacat caagtggcct tggtacatct ggctgggctt tatcgccgga     3660

ctgattgcca tcgtgatggt cacaatcatg ctgtgctgta tgaccagctg ctgtagctgc     3720

ctgaagggct gttgtagctg tggctcctgc tgcaagttcg acgaggacga ttctgagccc     3780

gtgctgaaag gcgtgaagct gcactacaca tga                                  3813


<210>  18
<211>  1270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-Omicron-2P protein of SARS-CoV-2

<400>  18

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Val Ile Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro 
65                  70                  75                  80  


Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Ile Glu Lys Ser 
                85                  90                  95      


Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr 
            100                 105                 110         


Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val 
        115                 120                 125             


Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Asp His Lys Asn Asn 
    130                 135                 140                 


Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn 
145                 150                 155                 160 


Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly 
                165                 170                 175     


Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile 
            180                 185                 190         


Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Ile Val Arg 
        195                 200                 205             


Glu Pro Glu Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val 
    210                 215                 220                 


Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Asp 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Leu 
        355                 360                 365             


Ala Pro Phe Phe Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Lys Leu Asp Ser Lys Val Ser Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Asn Lys Pro Cys Asn Gly Val 
465                 470                 475                 480 


Ala Gly Phe Asn Cys Tyr Phe Pro Leu Arg Ser Tyr Ser Phe Arg Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly His Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Lys 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu Tyr Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Lys Ser His Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Lys Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Tyr Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Lys Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn His Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Lys Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Phe Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1250                 1255                 1260             


Gly Val  Lys Leu His Tyr Thr  
    1265                 1270 


<210>  19
<211>  3825
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of the polynucleotide encoding S-2P protein 
       of SARS-CoV-2

<400>  19
atgttcgtgt ttctggtgct gctgccactg gtgtccagtc agtgcgtgaa cctgaccaca       60

cgaacacagc tgccaccagc ctacaccaat agcttcaccc gcggagtgta ctaccccgac      120

aaggtgttcc gcagcagcgt gctgcatagc acccaggatc tgtttctgcc cttcttcagc      180

aacgtgacct ggttccacgc catccacgtg tccggcacca atggcaccaa gcgcttcgat      240

aatcccgtgc tgcccttcaa cgatggcgtg tactttgcca gcaccgagaa gtccaatatc      300

atccgcggct ggatcttcgg caccacactg gatagcaaga cccagagcct gctgatcgtg      360

aacaacgcca ccaacgtggt catcaaagtg tgcgagttcc agttctgcaa cgaccccttc      420

ctgggcgtct actaccacaa gaacaacaag agctggatgg aaagcgagtt ccgcgtgtac      480

agcagcgcca acaactgcac cttcgagtac gtgtcccagc cattcctgat ggacctggaa      540

ggcaagcagg gcaacttcaa gaacctgcgc gagttcgtgt tcaagaacat cgacggctac      600

ttcaaaatct acagcaagca caccccaatc aacctcgtgc gcgatctgcc acagggattc      660

agtgctctgg aacccctggt ggatctgccc atcggcatca acattacccg ctttcagaca      720

ctgctggccc tgcaccgcag ttacttgaca ccaggcgata gcagcagtgg atggacagct      780

ggtgccgccg cttactacgt tggatatctg cagccacgca cctttctgct gaagtacaac      840

gagaacggca ccatcaccga cgccgtggat tgtgctctcg atcccctgag cgagacaaag      900

tgcaccctga agtccttcac cgtcgagaag ggcatctacc agaccagcaa tttccgcgtg      960

cagcccaccg agagcatcgt gcgcttcccc aatatcacca atctgtgccc cttcggcgag     1020

gtgttcaatg ccacacgctt tgcctccgtg tacgcctgga atcgcaagcg cattagcaac     1080

tgcgtggccg actactccgt gctgtacaat agcgccagct tcagcacctt caagtgctac     1140

ggcgtgtcac ccaccaagct gaacgacctg tgcttcacca atgtgtacgc cgacagcttc     1200

gtgatccgcg gagatgaagt gcgacagatt gccccaggcc agaccggcaa gatcgccgac     1260

tacaattaca agctgcccga cgacttcacc ggctgcgtga tcgcctggaa cagcaacaac     1320

ctggattcca aagtcggcgg caactacaac tacctgtacc gcctgttccg caagagcaat     1380

ctgaagccct tcgagcgcga catcagcacc gaaatctacc aggccggaag caccccatgc     1440

aacggcgtgg aaggcttcaa ctgctacttc ccactgcagt cctacggatt tcagcccaca     1500

aatggcgtgg gctaccagcc atatcgagtg gtggtgctga gcttcgaact gctgcatgct     1560

ccagctaccg tgtgcggccc caagaagagt accaacctgg tcaagaacaa atgcgtgaac     1620

ttcaacttca acggcctgac cggaaccggc gtgctgaccg agagtaacaa gaagttcctg     1680

ccattccagc agtttggccg cgacattgcc gatacaaccg atgccgttcg cgatccccag     1740

accttggaga tcctggatat taccccatgc tccttcggcg gcgtgtccgt gattacacca     1800

ggcaccaata ccagcaacca ggtggccgtt ctgtaccagg atgtgaattg cacagaggtg     1860

cccgtggcca ttcacgccga tcaattgaca ccaacatggc gcgtgtactc caccggcagc     1920

aatgtgtttc aaacccgcgc tggatgcctg attggagccg agcacgtgaa caatagctac     1980

gagtgcgata tccccatcgg agccggaatc tgcgcctcct atcagaccca gaccaatagt     2040

ccacgacgag cccgaagtgt ggccagccag agcatcattg cctataccat gagcctgggc     2100

gccgagaata gcgtggccta ctccaacaac agcattgcta tccccaccaa cttcaccatc     2160

agcgtgacca ccgagatcct gccagtgtcc atgaccaaga ccagcgtgga ctgcaccatg     2220

tacatctgcg gagatagcac cgagtgcagc aacctgctgc tgcagtacgg aagtttctgc     2280

acccagctga atcgcgccct gacaggcatt gccgtggaac aggataagaa cacccaagag     2340

gtgttcgccc aagtgaagca aatctacaag accccaccaa tcaaggattt cggcggcttc     2400

aatttcagcc agattctgcc cgatccaagc aagcccagca agcgcagctt catcgaggac     2460

ctgctgttca acaaagtgac actggccgac gccggattca tcaagcagta tggcgattgc     2520

ctgggcgata ttgccgcacg cgatctgatt tgcgcccaga agtttaacgg actgaccgtc     2580

ctgccaccac tgctgacaga tgagatgatc gcccagtaca caagtgccct gctggccgga     2640

accattacca gcggatggac atttggagcc ggtgccgctc tgcagattcc cttcgctatg     2700

cagatggcct accgcttcaa tggcattggc gtgacccaga atgtgctgta cgagaaccag     2760

aagctgatcg ccaaccagtt caacagcgcc atcggcaaga ttcaggacag cctgagtagt     2820

accgccagcg ctctgggaaa gctgcaggat gtggtcaacc agaacgctca ggccctgaac     2880

accctggtta agcagctgag cagcaacttc ggcgccatca gtagcgtgct gaacgatatc     2940

ctgagccgcc tggatccacc agaagccgag gtgcagatcg atcgcctgat taccggacgc     3000

ctgcagtccc tgcagaccta tgtgacacag cagctgatcc gagccgccga gattcgagct     3060

agtgctaatc tggccgccac caagatgagc gaatgtgtgc tgggacagag caagcgcgtg     3120

gacttttgcg gcaagggata ccacctgatg agcttcccac agagtgctcc acacggcgtg     3180

gtgtttctgc atgtgaccta cgtgcccgct caagagaaga atttcaccac cgctccagcc     3240

atctgccacg acggaaaggc ccattttcca cgcgagggcg tgttcgttag caacggcact     3300

cattggttcg tcacccagcg caacttctac gagccccaga tcatcaccac cgacaacacc     3360

ttcgtcagcg gcaactgcga cgtcgtgatc ggcattgtga acaacaccgt gtacgatcca     3420

ctgcagcccg agctggacag cttcaaagag gaactggaca agtactttaa gaaccacaca     3480

agccccgacg tggacctggg agacattagc ggaatcaacg ccagcgtggt caacatccag     3540

aaagagattg accgcctgaa cgaggtggcc aagaatctga acgagagcct gatcgacctg     3600

caagaactgg gcaaatacga gcagtacatt aagtggccct ggtacatctg gctgggcttc     3660

attgccggac tgattgccat cgtgatggtc accattatgc tgtgctgcat gaccagttgc     3720

tgcagctgcc tgaagggatg ctgcagttgc ggaagctgct gcaagttcga cgaggatgat     3780

agcgagccag tgctgaaggg cgtcaagctg cactacacct gataa                     3825


<210>  20
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   S-2P protein of SARS-CoV-2

<400>  20

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  21
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  21

Arg Arg Ala Arg 
1               


<210>  22
<211>  10096
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of pFlap-ieCMV-S-B351-2P-WPREm

<400>  22
ggcgttggga gctttttgca aaagcctagg cctccaaaaa agcctcctca ctacttctgg       60

aatagctcag aggcagaggc ggcctcggcc tctgcataaa taaaaaaaat tagtcagcca      120

tggggcggag aatgggcgga actgggcgga gttaggggcg ggatgggcgg agttaggggc      180

gggactatgg ttgctgacta attgagatgc ccgacattga ttattgacta gttggaaggg      240

ctaattcact cccaaagaag acaagatatc cttgatctgt ggatctacca cacacaaggc      300

tacttccctg attagcagaa ctacacacca gggccagggg tcagatatcc actgaccttt      360

ggatggtgct acaagctagt accagttgag ccagataagg tagaagaggc caataaagga      420

gagaacacca gcttgttaca ccctgtgagc ctgcatggga tggatgaccc ggagagagaa      480

gtgttagagt ggaggtttga cagccgccta gcatttcatc acgtggcccg agagctgcat      540

ccggagtact tcaagaactg ctgatatcga gcttgctaca agggactttc cgctggggac      600

tttccaggga ggcgtggcct gggcgggact ggggagtggc gagccctcag atcctgcata      660

taagcagctg ctttttgcct gtactgggtc tctctggtta gaccagatct gagcctggga      720

gctctctggc taactaggga acccactgct taagcctcaa taaagcttgc cttgagtgct      780

tcaagtagtg tgtgcccgtc tgttgtgtga ctctggtaac tagagatccc tcagaccctt      840

ttagtcagtg tggaaaatct ctagcagtgg cgcccgaaca gggacttgaa agcgaaaggg      900

aaaccagagg agctctctcg acgcaggact cggcttgctg aagcgcgcac ggcaagaggc      960

gaggggcggc gactggtgag tacgccaaaa attttgacta gcggaggcta gaaggagaga     1020

gatgggtgcg agagcgtcag tattaagcgg gggagaatta gatcgcgatg ggaaaaaatt     1080

cggttaaggc cagggggaaa gaaaaaatat aaattaaaac atatagtatg ggcaagcagg     1140

gagctagaac gattcgcagt taatcctggc ctgttagaaa catcagaagg ctgtagacaa     1200

atactgggac agctacaacc atcccttcag acaggatcag aagaacttag atcattatat     1260

aatacagtag caaccctcta ttgtgtgcat caaaggatag agataaaaga caccaaggaa     1320

gctttagaca agatagagga agagcaaaac aaaagtaaga ccaccgcaca gcaagcggcc     1380

gctgatcttc agacctggag gaggagatat gagggacaat tggagaagtg aattatataa     1440

atataaagta gtaaaaattg aaccattagg agtagcaccc accaaggcaa agagaagagt     1500

ggtgcagaga gaaaaaagag cagtgggaat aggagctttg ttccttgggt tcttgggagc     1560

agcaggaagc actatgggcg cagcgtcaat gacgctgacg gtacaggcca gacaattatt     1620

gtctggtata gtgcagcagc agaacaattt gctgagggct attgaggcgc aacagcatct     1680

gttgcaactc acagtctggg gcatcaagca gctccaggca agaatcctgg ctgtggaaag     1740

atacctaaag gatcaacagc tcctggggat ttggggttgc tctggaaaac tcatttgcac     1800

cactgctgtg ccttggaatg ctagttggag taataaatct ctggaacaga tttggaatca     1860

cacgacctgg atggagtggg acagagaaat taacaattac acaagcttaa tacactcctt     1920

aattgaagaa tcgcaaaacc agcaagaaaa gaatgaacaa gaattattgg aattagataa     1980

atgggcaagt ttgtggaatt ggtttaacat aacaaattgg ctgtggtata taaaattatt     2040

cataatgata gtaggaggct tggtaggttt aagaatagtt tttgctgtac tttctatagt     2100

gaatagagtt aggcagggat attcaccatt atcgtttcag acccacctcc caaccccgag     2160

gggacccgac aggcccgaag gaatagaaga agaaggtgga gagagagaca gagacagatc     2220

cattcgatta gtgaacggat ctcgacggta tcgccgaatt cacaaatggc agtattcatc     2280

cacaatttta aaagaaaagg ggggattggg gggtacagtg caggggaaag aatagtagac     2340

ataatagcaa cagacataca aactaaagaa ttacaaaaac aaattacaaa aattcaaaat     2400

tttcgggttt attacaggga cagcagagat ccactttggc tgatacgcgt ggagttccgc     2460

gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg     2520

acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa     2580

tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca     2640

agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac     2700

atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc     2760

atggtgatgc ggttttggca gtacatcaat gggcgtggat agcggtttga ctcacgggga     2820

tttccaagtc tccaccccat tgacgtcaat gggagtttgt tttggcacca aaatcaacgg     2880

gactttccaa aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg taggcgtgta     2940

cggtgggagg tctatataag cagagctcgt ttagtgaacc gtcagatcgc ctggagacgc     3000

catccacgct gttttgacct ccatagaaga caccgcgatc ggatccacaa gtttgtacaa     3060

aaaagcaggc tgccaccatg ttcgtgtttc tggtgctgct gccactggtg tccagtcagt     3120

gcgtgaactt caccacacga acacagctgc caccagccta caccaatagc ttcacccgcg     3180

gagtgtacta ccccgacaag gtgttccgca gcagcgtgct gcatagcacc caggatctgt     3240

ttctgccctt cttcagcaac gtgacctggt tccacgccat ccacgtgtcc ggcaccaatg     3300

gcaccaagcg cttcgctaat cccgtgctgc ccttcaacga tggcgtgtac tttgccagca     3360

ccgagaagtc caatatcatc cgcggctgga tcttcggcac cacactggat agcaagaccc     3420

agagcctgct gatcgtgaac aacgccacca acgtggtcat caaagtgtgc gagttccagt     3480

tctgcaacga ccccttcctg ggcgtctact accacaagaa caacaagagc tggatggaaa     3540

gcgagttccg cgtgtacagc agcgccaaca actgcacctt cgagtacgtg tcccagccat     3600

tcctgatgga cctggaaggc aagcagggca acttcaagaa cctgcgcgag ttcgtgttca     3660

agaacatcga cggctacttc aaaatctaca gcaagcacac cccaatcaac ctcgtgcgcg     3720

gcctgccaca gggattcagt gctctggaac ccctggtgga tctgcccatc ggcatcaaca     3780

ttacccgctt tcagacactg caccgcagtt acttgacacc aggcgatagc agcagtggat     3840

ggacagctgg tgccgccgct tactacgttg gatatctgca gccacgcacc tttctgctga     3900

agtacaacga gaacggcacc atcaccgacg ccgtggattg tgctctcgat cccctgagcg     3960

agacaaagtg caccctgaag tccttcaccg tcgagaaggg catctaccag accagcaatt     4020

tccgcgtgca gcccaccgag agcatcgtgc gcttccccaa tatcaccaat ctgtgcccct     4080

tcggcgaggt gttcaatgcc acacgctttg cctccgtgta cgcctggaat cgcaagcgca     4140

ttagcaactg cgtggccgac tactccgtgc tgtacaatag cgccagcttc agcaccttca     4200

agtgctacgg cgtgtcaccc accaagctga acgacctgtg cttcaccaat gtgtacgccg     4260

acagcttcgt gatccgcgga gatgaagtgc gacagattgc cccaggccag accggcaaca     4320

tcgccgacta caattacaag ctgcccgacg acttcaccgg ctgcgtgatc gcctggaaca     4380

gcaacaacct ggattccaaa gtcggcggca actacaacta cctgtaccgc ctgttccgca     4440

agagcaatct gaagcccttc gagcgcgaca tcagcaccga aatctaccag gccggaagca     4500

ccccatgcaa cggcgtgaaa ggcttcaact gctacttccc actgcagtcc tacggatttc     4560

agcccacata tggcgtgggc taccagccat atcgagtggt ggtgctgagc ttcgaactgc     4620

tgcatgctcc agctaccgtg tgcggcccca agaagagtac caacctggtc aagaacaaat     4680

gcgtgaactt caacttcaac ggcctgaccg gaaccggcgt gctgaccgag agtaacaaga     4740

agttcctgcc attccagcag tttggccgcg acattgccga tacaaccgat gccgttcgcg     4800

atccccagac cttggagatc ctggatatta ccccatgctc cttcggcggc gtgtccgtga     4860

ttacaccagg caccaatacc agcaaccagg tggccgttct gtaccagggc gtgaattgca     4920

cagaggtgcc cgtggccatt cacgccgatc aattgacacc aacatggcgc gtgtactcca     4980

ccggcagcaa tgtgtttcaa acccgcgctg gatgcctgat tggagccgag cacgtgaaca     5040

atagctacga gtgcgatatc cccatcggag ccggaatctg cgcctcctat cagacccaga     5100

ccaatagtcc acgacgagcc cgaagtgtgg ccagccagag catcattgcc tataccatga     5160

gcctgggcgt ggagaatagc gtggcctact ccaacaacag cattgctatc cccaccaact     5220

tcaccatcag cgtgaccacc gagatcctgc cagtgtccat gaccaagacc agcgtggact     5280

gcaccatgta catctgcgga gatagcaccg agtgcagcaa cctgctgctg cagtacggaa     5340

gtttctgcac ccagctgaat cgcgccctga caggcattgc cgtggaacag gataagaaca     5400

cccaagaggt gttcgcccaa gtgaagcaaa tctacaagac cccaccaatc aaggatttcg     5460

gcggcttcaa tttcagccag attctgcccg atccaagcaa gcccagcaag cgcagcttca     5520

tcgaggacct gctgttcaac aaagtgacac tggccgacgc cggattcatc aagcagtatg     5580

gcgattgcct gggcgatatt gccgcacgcg atctgatttg cgcccagaag tttaacggac     5640

tgaccgtcct gccaccactg ctgacagatg agatgatcgc ccagtacaca agtgccctgc     5700

tggccggaac cattaccagc ggatggacat ttggagccgg tgccgctctg cagattccct     5760

tcgctatgca gatggcctac cgcttcaatg gcattggcgt gacccagaat gtgctgtacg     5820

agaaccagaa gctgatcgcc aaccagttca acagcgccat cggcaagatt caggacagcc     5880

tgagtagtac cgccagcgct ctgggaaagc tgcaggatgt ggtcaaccag aacgctcagg     5940

ccctgaacac cctggttaag cagctgagca gcaacttcgg cgccatcagt agcgtgctga     6000

acgatatcct gagccgcctg gatccgccgg aagccgaggt gcagatcgat cgcctgatta     6060

ccggacgcct gcagtccctg cagacctatg tgacacagca gctgatccga gccgccgaga     6120

ttcgagctag tgctaatctg gccgccacca agatgagcga atgtgtgctg ggacagagca     6180

agcgcgtgga cttttgcggc aagggatacc acctgatgag cttcccacag agtgctccac     6240

acggcgtggt gtttctgcat gtgacctacg tgcccgctca agagaagaat ttcaccaccg     6300

ctccagccat ctgccacgac ggaaaggccc attttccacg cgagggcgtg ttcgttagca     6360

acggcactca ttggttcgtc acccagcgca acttctacga gccccagatc atcaccaccg     6420

acaacacctt cgtcagcggc aactgcgacg tcgtgatcgg cattgtgaac aacaccgtgt     6480

acgatccact gcagcccgag ctggacagct tcaaagagga actggacaag tactttaaga     6540

accacacaag ccccgacgtg gacctgggag acattagcgg aatcaacgcc agcgtggtca     6600

acatccagaa agagattgac cgcctgaacg aggtggccaa gaatctgaac gagagcctga     6660

tcgacctgca agaactgggc aaatacgagc agtacattaa gtggccctgg tacatctggc     6720

tgggcttcat tgccggactg attgccatcg tgatggtcac cattatgctg tgctgcatga     6780

ccagttgctg cagctgcctg aagggatgct gcagttgcgg aagctgctgc aagttcgacg     6840

aggatgatag cgagccagtg ctgaagggcg tcaagctgca ctacacctga tagtaaaccc     6900

agctttcttg tacaaagtgg tctcgagttc ccgataatca acctctggat tacaaaattt     6960

gtgaaagatt gactggtatt cttaactatg ttgctccttt tacgctatgt ggatacgctg     7020

ctttaatgcc tttgtatcat gctattgctt cccgtatggc tttcattttc tcctccttgt     7080

ataaatcctg gttgctgtct ctttatgagg agttgtggcc cgttgtcagg caacgtggcg     7140

tggtgtgcac tgtgtttgct gacgcaaccc ccactggttg gggcattgcc accacctgtc     7200

agctcctttc cgggactttc gctttccccc tccctattgc cacggcggaa ctcatcgccg     7260

cctgccttgc ccgctgctgg acaggggctc ggctgttggg cactgacaat tccgtggtgt     7320

tgtcggggaa gctgacgtcc tttccgcggc tgctcgcctg tgttgccacc tggattctgc     7380

gcgggacgtc cttctgctac gtcccttcgg ccctcaatcc agcggacctt ccttcccgcg     7440

gcctgctgcc ggctctgcgg cctcttccgc gtcttcgcct tcgccctcag acgagtcgga     7500

tctccctttg ggccgcctcc ccgcggtacc tttaagacca atgacttaca aggcagctgt     7560

agatcttagc cactttttaa aagaaaaggg gggactggaa gggctaattc actcccaacg     7620

aagacaaaat cgtcgagaga tgctgcatat aagcagctgc tttttgcttg tactgggtct     7680

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt     7740

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac     7800

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagttct     7860

agagggcccg tttaaacccg ctgatcagcc tcgactgtgc cttctagttg ccagccatct     7920

gttgtttgcc cctcccccgt gccttccttg accctggaag gtgccactcc cactgtcctt     7980

tcctaataaa atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc tattctgggg     8040

ggtggggtgg ggcaggacag caagggggag gattgggaag acaatagcag gcatgctggg     8100

gatgcggtgg gctctatggc ttctactggg cggttttatg gacagcaagc gaaccggaat     8160

tgccagctgg ggcgccctct ggtaaggttg ggaagccctg caaagtaaac tggatggctt     8220

tcttgccgcc aaggatctga tggcgcaggg gatcaagctc tgatcaagag acaggatgag     8280

gatcgtttcg catgattgaa caagatggat tgcacgcagg ttctccggcc gcttgggtgg     8340

agaggctatt cggctatgac tgggcacaac agacaatcgg ctgctctgat gccgccgtgt     8400

tccggctgtc agcgcagggg cgcccggttc tttttgtcaa gaccgacctg tccggtgccc     8460

tgaatgaact gcaagacgag gcagcgcggc tatcgtggct ggccacgacg ggcgttcctt     8520

gcgcagctgt gctcgacgtt gtcactgaag cgggaaggga ctggctgcta ttgggcgaag     8580

tgccggggca ggatctcctg tcatctcacc ttgctcctgc cgagaaagta tccatcatgg     8640

ctgatgcaat gcggcggctg catacgcttg atccggctac ctgcccattc gaccaccaag     8700

cgaaacatcg catcgagcga gcacgtactc ggatggaagc cggtcttgtc gatcaggatg     8760

atctggacga agagcatcag gggctcgcgc cagccgaact gttcgccagg ctcaaggcga     8820

gcatgcccga cggcgaggat ctcgtcgtga cccatggcga tgcctgcttg ccgaatatca     8880

tggtggaaaa tggccgcttt tctggattca tcgactgtgg ccggctgggt gtggcggacc     8940

gctatcagga catagcgttg gctacccgtg atattgctga agagcttggc ggcgaatggg     9000

ctgaccgctt cctcgtgctt tacggtatcg ccgctcccga ttcgcagcgc atcgccttct     9060

atcgccttct tgacgagttc ttctgaatta ttaacgctta caatttcctg atgcggtatt     9120

ttctccttac gcatctgtgc ggtatttcac accgcatcag gtggcacttt tcggggaaat     9180

gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg     9240

agacaataac cctgataaat gcttcaataa tagcacgtgc taaaacttca tttttaattt     9300

aaaaggatct aggtgaagat cctttttgat aatctcatga ccaaaatccc ttaacgtgag     9360

ttttcgttcc actgagcgtc agaccccgta gaaaagatca aaggatcttc ttgagatcct     9420

ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt     9480

tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt cagcagagcg     9540

cagataccaa atactgttct tctagtgtag ccgtagttag gccaccactt caagaactct     9600

gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc tgccagtggc     9660

gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa ggcgcagcgg     9720

tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac ctacaccgaa     9780

ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg     9840

gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga gcttccaggg     9900

ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact tgagcgtcga     9960

tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa cgcggccttt    10020

ttacggttcc tggccttttg ctggcctttt gctcacatgt tcttgctgct tcgcgatgta    10080

cgggccagat atacgc                                                    10096


