                         SEQUENCE LISTING

<110>  GUANGZHOU RIBOBIO CO., LTD.
       ARGORNA PHARMACEUTICALS CO., LTD 
 
<120>  VACCINES AND COMPOSITIONS BASED ON SARS-COV-2 S PROTEIN

<130>  C21W0740

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  1271
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of recombinant S protein

<400>  1

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Arg Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Asp Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Gly Val Tyr Ser Ser 
145                 150                 155                 160 


Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp 
                165                 170                 175     


Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe 
            180                 185                 190         


Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile 
        195                 200                 205             


Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Val Leu Glu Pro Leu 
    210                 215                 220                 


Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu 
225                 230                 235                 240 


Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp 
                245                 250                 255     


Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr 
            260                 265                 270         


Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp 
        275                 280                 285             


Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe 
    290                 295                 300                 


Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro 
305                 310                 315                 320 


Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe 
                325                 330                 335     


Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn 
            340                 345                 350         


Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn 
        355                 360                 365             


Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys 
    370                 375                 380                 


Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile 
385                 390                 395                 400 


Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile 
                405                 410                 415     


Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile 
            420                 425                 430         


Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn 
        435                 440                 445             


Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg 
    450                 455                 460                 


Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Lys Pro Cys Asn Gly 
465                 470                 475                 480 


Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln 
                485                 490                 495     


Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser 
            500                 505                 510         


Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser 
        515                 520                 525             


Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu 
    530                 535                 540                 


Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe 
545                 550                 555                 560 


Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp 
                565                 570                 575     


Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly 
            580                 585                 590         


Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val 
        595                 600                 605             


Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala 
    610                 615                 620                 


Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val 
625                 630                 635                 640 


Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn 
                645                 650                 655     


Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr 
            660                 665                 670         


Gln Thr Gln Thr Asn Ser Arg Arg Arg Ala Arg Ser Val Ala Ser Gln 
        675                 680                 685             


Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala 
    690                 695                 700                 


Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val 
705                 710                 715                 720 


Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys 
                725                 730                 735     


Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu 
            740                 745                 750         


Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile 
        755                 760                 765             


Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys 
    770                 775                 780                 


Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe 
785                 790                 795                 800 


Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile 
                805                 810                 815     


Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile 
            820                 825                 830         


Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile 
        835                 840                 845             


Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr 
    850                 855                 860                 


Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile 
865                 870                 875                 880 


Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe 
                885                 890                 895     


Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn 
            900                 905                 910         


Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala 
        915                 920                 925             


Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly 
    930                 935                 940                 


Lys Leu Gln Asn Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu 
945                 950                 955                 960 


Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn 
                965                 970                 975     


Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp 
            980                 985                 990         


Arg Leu Ile Thr Gly Arg Leu Gln  Ser Leu Gln Thr Tyr  Val Thr Gln 
        995                 1000                 1005             


Gln Leu  Ile Arg Ala Ala Glu  Ile Arg Ala Ser Ala  Asn Leu Ala 
    1010                 1015                 1020             


Ala Thr  Lys Met Ser Glu Cys  Val Leu Gly Gln Ser  Lys Arg Val 
    1025                 1030                 1035             


Asp Phe  Cys Gly Lys Gly Tyr  His Leu Met Ser Phe  Pro Gln Ser 
    1040                 1045                 1050             


Ala Pro  His Gly Val Val Phe  Leu His Val Thr Tyr  Val Pro Ala 
    1055                 1060                 1065             


Gln Glu  Lys Asn Phe Thr Thr  Ala Pro Ala Ile Cys  His Asp Gly 
    1070                 1075                 1080             


Lys Ala  His Phe Pro Arg Glu  Gly Val Phe Val Ser  Asn Gly Thr 
    1085                 1090                 1095             


His Trp  Phe Val Thr Gln Arg  Asn Phe Tyr Glu Pro  Gln Ile Ile 
    1100                 1105                 1110             


Thr Thr  Asp Asn Thr Phe Val  Ser Gly Asn Cys Asp  Val Val Ile 
    1115                 1120                 1125             


Gly Ile  Val Asn Asn Thr Val  Tyr Asp Pro Leu Gln  Pro Glu Leu 
    1130                 1135                 1140             


Asp Ser  Phe Lys Glu Glu Leu  Asp Lys Tyr Phe Lys  Asn His Thr 
    1145                 1150                 1155             


Ser Pro  Asp Val Asp Leu Gly  Asp Ile Ser Gly Ile  Asn Ala Ser 
    1160                 1165                 1170             


Val Val  Asn Ile Gln Lys Glu  Ile Asp Arg Leu Asn  Glu Val Ala 
    1175                 1180                 1185             


Lys Asn  Leu Asn Glu Ser Leu  Ile Asp Leu Gln Glu  Leu Gly Lys 
    1190                 1195                 1200             


Tyr Glu  Gln Tyr Ile Lys Trp  Pro Trp Tyr Ile Trp  Leu Gly Phe 
    1205                 1210                 1215             


Ile Ala  Gly Leu Ile Ala Ile  Val Met Val Thr Ile  Met Leu Cys 
    1220                 1225                 1230             


Cys Met  Thr Ser Cys Cys Ser  Cys Leu Lys Gly Cys  Cys Ser Cys 
    1235                 1240                 1245             


Gly Ser  Cys Cys Lys Phe Asp  Glu Asp Asp Ser Glu  Pro Val Leu 
    1250                 1255                 1260             


Lys Gly  Val Lys Leu His Tyr  Thr 
    1265                 1270     


<210>  2
<211>  1271
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of recombinant S protein

<400>  2

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Arg Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Asp Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Gly Val Tyr Ser Ser 
145                 150                 155                 160 


Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp 
                165                 170                 175     


Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe 
            180                 185                 190         


Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile 
        195                 200                 205             


Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Val Leu Glu Pro Leu 
    210                 215                 220                 


Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu 
225                 230                 235                 240 


Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp 
                245                 250                 255     


Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr 
            260                 265                 270         


Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp 
        275                 280                 285             


Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe 
    290                 295                 300                 


Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro 
305                 310                 315                 320 


Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe 
                325                 330                 335     


Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn 
            340                 345                 350         


Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn 
        355                 360                 365             


Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys 
    370                 375                 380                 


Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile 
385                 390                 395                 400 


Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile 
                405                 410                 415     


Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile 
            420                 425                 430         


Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn 
        435                 440                 445             


Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg 
    450                 455                 460                 


Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Lys Pro Cys Asn Gly 
465                 470                 475                 480 


Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln 
                485                 490                 495     


Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser 
            500                 505                 510         


Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser 
        515                 520                 525             


Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu 
    530                 535                 540                 


Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe 
545                 550                 555                 560 


Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp 
                565                 570                 575     


Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly 
            580                 585                 590         


Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val 
        595                 600                 605             


Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala 
    610                 615                 620                 


Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val 
625                 630                 635                 640 


Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn 
                645                 650                 655     


Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr 
            660                 665                 670         


Gln Thr Gln Thr Asn Ser Arg Gly Gly Ser Gly Ser Val Ala Ser Gln 
        675                 680                 685             


Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala 
    690                 695                 700                 


Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val 
705                 710                 715                 720 


Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys 
                725                 730                 735     


Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu 
            740                 745                 750         


Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile 
        755                 760                 765             


Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys 
    770                 775                 780                 


Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe 
785                 790                 795                 800 


Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Ala Asn Ser Phe Ile 
                805                 810                 815     


Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile 
            820                 825                 830         


Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile 
        835                 840                 845             


Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr 
    850                 855                 860                 


Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile 
865                 870                 875                 880 


Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe 
                885                 890                 895     


Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn 
            900                 905                 910         


Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala 
        915                 920                 925             


Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly 
    930                 935                 940                 


Lys Leu Gln Asn Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu 
945                 950                 955                 960 


Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn 
                965                 970                 975     


Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp 
            980                 985                 990         


Arg Leu Ile Thr Gly Arg Leu Gln  Ser Leu Gln Thr Tyr  Val Thr Gln 
        995                 1000                 1005             


Gln Leu  Ile Arg Ala Ala Glu  Ile Arg Ala Ser Ala  Asn Leu Ala 
    1010                 1015                 1020             


Ala Thr  Lys Met Ser Glu Cys  Val Leu Gly Gln Ser  Lys Arg Val 
    1025                 1030                 1035             


Asp Phe  Cys Gly Lys Gly Tyr  His Leu Met Ser Phe  Pro Gln Ser 
    1040                 1045                 1050             


Ala Pro  His Gly Val Val Phe  Leu His Val Thr Tyr  Val Pro Ala 
    1055                 1060                 1065             


Gln Glu  Lys Asn Phe Thr Thr  Ala Pro Ala Ile Cys  His Asp Gly 
    1070                 1075                 1080             


Lys Ala  His Phe Pro Arg Glu  Gly Val Phe Val Ser  Asn Gly Thr 
    1085                 1090                 1095             


His Trp  Phe Val Thr Gln Arg  Asn Phe Tyr Glu Pro  Gln Ile Ile 
    1100                 1105                 1110             


Thr Thr  Asp Asn Thr Phe Val  Ser Gly Asn Cys Asp  Val Val Ile 
    1115                 1120                 1125             


Gly Ile  Val Asn Asn Thr Val  Tyr Asp Pro Leu Gln  Pro Glu Leu 
    1130                 1135                 1140             


Asp Ser  Phe Lys Glu Glu Leu  Asp Lys Tyr Phe Lys  Asn His Thr 
    1145                 1150                 1155             


Ser Pro  Asp Val Asp Leu Gly  Asp Ile Ser Gly Ile  Asn Ala Ser 
    1160                 1165                 1170             


Val Val  Asn Ile Gln Lys Glu  Ile Asp Arg Leu Asn  Glu Val Ala 
    1175                 1180                 1185             


Lys Asn  Leu Asn Glu Ser Leu  Ile Asp Leu Gln Glu  Leu Gly Lys 
    1190                 1195                 1200             


Tyr Glu  Gln Tyr Ile Lys Trp  Pro Trp Tyr Ile Trp  Leu Gly Phe 
    1205                 1210                 1215             


Ile Ala  Gly Leu Ile Ala Ile  Val Met Val Thr Ile  Met Leu Cys 
    1220                 1225                 1230             


Cys Met  Thr Ser Cys Cys Ser  Cys Leu Lys Gly Cys  Cys Ser Cys 
    1235                 1240                 1245             


Gly Ser  Cys Cys Lys Phe Asp  Glu Asp Asp Ser Glu  Pro Val Leu 
    1250                 1255                 1260             


Lys Gly  Val Lys Leu His Tyr  Thr 
    1265                 1270     


<210>  3
<211>  1271
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of recombinant S protein

<400>  3

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Arg Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Asp Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Gly Val Tyr Ser Ser 
145                 150                 155                 160 


Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp 
                165                 170                 175     


Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe 
            180                 185                 190         


Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile 
        195                 200                 205             


Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Val Leu Glu Pro Leu 
    210                 215                 220                 


Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu 
225                 230                 235                 240 


Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp 
                245                 250                 255     


Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr 
            260                 265                 270         


Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp 
        275                 280                 285             


Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe 
    290                 295                 300                 


Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro 
305                 310                 315                 320 


Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe 
                325                 330                 335     


Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn 
            340                 345                 350         


Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn 
        355                 360                 365             


Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys 
    370                 375                 380                 


Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile 
385                 390                 395                 400 


Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile 
                405                 410                 415     


Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile 
            420                 425                 430         


Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn 
        435                 440                 445             


Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg 
    450                 455                 460                 


Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Lys Pro Cys Asn Gly 
465                 470                 475                 480 


Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln 
                485                 490                 495     


Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser 
            500                 505                 510         


Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser 
        515                 520                 525             


Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu 
    530                 535                 540                 


Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe 
545                 550                 555                 560 


Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp 
                565                 570                 575     


Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly 
            580                 585                 590         


Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val 
        595                 600                 605             


Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala 
    610                 615                 620                 


Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val 
625                 630                 635                 640 


Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn 
                645                 650                 655     


Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr 
            660                 665                 670         


Gln Thr Gln Thr Asn Ser Arg Gly Gly Ser Gly Ser Val Ala Ser Gln 
        675                 680                 685             


Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala 
    690                 695                 700                 


Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val 
705                 710                 715                 720 


Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys 
                725                 730                 735     


Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu 
            740                 745                 750         


Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile 
        755                 760                 765             


Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys 
    770                 775                 780                 


Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe 
785                 790                 795                 800 


Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Ala Asn Ser Phe Ile 
                805                 810                 815     


Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile 
            820                 825                 830         


Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile 
        835                 840                 845             


Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr 
    850                 855                 860                 


Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile 
865                 870                 875                 880 


Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe 
                885                 890                 895     


Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn 
            900                 905                 910         


Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala 
        915                 920                 925             


Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly 
    930                 935                 940                 


Lys Leu Gln Asn Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu 
945                 950                 955                 960 


Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn 
                965                 970                 975     


Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp 
            980                 985                 990         


Arg Leu Ile Thr Gly Arg Leu Gln  Ser Leu Gln Thr Tyr  Val Thr Gln 
        995                 1000                 1005             


Gln Leu  Ile Arg Ala Ala Glu  Ile Arg Ala Ser Ala  Asn Leu Ala 
    1010                 1015                 1020             


Ala Thr  Lys Met Ser Glu Cys  Val Leu Gly Gln Ser  Lys Arg Val 
    1025                 1030                 1035             


Asp Phe  Cys Gly Lys Gly Tyr  His Leu Met Ser Phe  Pro Gln Ser 
    1040                 1045                 1050             


Ala Pro  His Gly Val Val Phe  Leu His Val Thr Tyr  Val Pro Ala 
    1055                 1060                 1065             


Gln Glu  Lys Asn Phe Thr Thr  Ala Pro Ala Ile Cys  His Asp Gly 
    1070                 1075                 1080             


Lys Ala  His Phe Pro Arg Glu  Gly Val Phe Val Ser  Asn Gly Thr 
    1085                 1090                 1095             


His Trp  Phe Val Thr Gln Arg  Asn Phe Tyr Glu Pro  Gln Ile Ile 
    1100                 1105                 1110             


Thr Thr  Asp Asn Thr Phe Val  Ser Gly Asn Cys Asp  Val Val Ile 
    1115                 1120                 1125             


Gly Ile  Val Asn Asn Thr Val  Tyr Asp Pro Leu Gln  Pro Glu Leu 
    1130                 1135                 1140             


Asp Ser  Phe Lys Glu Glu Leu  Asp Lys Tyr Phe Lys  Asn His Thr 
    1145                 1150                 1155             


Ser Pro  Asp Val Asp Leu Gly  Asp Ile Ser Gly Ile  Asn Ala Ser 
    1160                 1165                 1170             


Val Val  Asn Ile Gln Lys Glu  Ile Asp Arg Leu Asn  Glu Val Ala 
    1175                 1180                 1185             


Lys Asn  Leu Asn Glu Ser Leu  Ile Asp Leu Gln Glu  Leu Gly Lys 
    1190                 1195                 1200             


Tyr Glu  Gln Tyr Ile Lys Trp  Pro Trp Tyr Ile Trp  Leu Gly Phe 
    1205                 1210                 1215             


Ile Ala  Gly Leu Ile Ala Ile  Val Met Val Thr Ile  Met Leu Cys 
    1220                 1225                 1230             


Cys Met  Thr Ser Cys Cys Ser  Cys Leu Lys Gly Cys  Cys Ser Cys 
    1235                 1240                 1245             


Gly Ser  Cys Cys Lys Phe Asp  Glu Asp Asp Ser Glu  Pro Val Leu 
    1250                 1255                 1260             


Lys Gly  Val Lys Leu His Tyr  Thr 
    1265                 1270     


<210>  4
<211>  1229
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of recombinant S protein

<400>  4

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Cys Val Asn Leu Arg Thr Arg Thr Gln Leu Pro Pro 
            20                  25                  30          


Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val 
        35                  40                  45              


Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe 
    50                  55                  60                  


Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn 
65                  70                  75                  80  


Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val 
                85                  90                  95      


Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe 
            100                 105                 110         


Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn 
        115                 120                 125             


Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp 
    130                 135                 140                 


Pro Phe Leu Asp Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu 
145                 150                 155                 160 


Ser Gly Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser 
                165                 170                 175     


Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn 
            180                 185                 190         


Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr 
        195                 200                 205             


Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe 
    210                 215                 220                 


Ser Val Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr 
225                 230                 235                 240 


Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly 
                245                 250                 255     


Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly 
            260                 265                 270         


Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr 
        275                 280                 285             


Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys 
    290                 295                 300                 


Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser 
305                 310                 315                 320 


Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile 
                325                 330                 335     


Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala 
            340                 345                 350         


Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp 
        355                 360                 365             


Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr 
    370                 375                 380                 


Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr 
385                 390                 395                 400 


Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro 
                405                 410                 415     


Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
            420                 425                 430         


Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys 
        435                 440                 445             


Val Gly Gly Asn Tyr Asn Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn 
    450                 455                 460                 


Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly 
465                 470                 475                 480 


Ser Lys Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu 
                485                 490                 495     


Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr 
            500                 505                 510         


Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val 
        515                 520                 525             


Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn 
    530                 535                 540                 


Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn 
545                 550                 555                 560 


Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr 
                565                 570                 575     


Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr 
            580                 585                 590         


Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr 
        595                 600                 605             


Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val 
    610                 615                 620                 


Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr 
625                 630                 635                 640 


Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly 
                645                 650                 655     


Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala 
            660                 665                 670         


Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Gly Ser 
        675                 680                 685             


Gly Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly 
    690                 695                 700                 


Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr 
705                 710                 715                 720 


Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr 
                725                 730                 735     


Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu 
            740                 745                 750         


Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn 
        755                 760                 765             


Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu 
    770                 775                 780                 


Val Phe Ala Gln Val Lys Gln Pro Asp Pro Ser Lys Pro Ser Ala Asn 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asn Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1130                 1135                 1140             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1145                 1150                 1155             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1160                 1165                 1170             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1175                 1180                 1185             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Ser Ala  Ile Gly Gly 
    1190                 1195                 1200             


Tyr Ile  Pro Glu Ala Pro Arg  Asp Gly Gln Ala Tyr  Val Arg Lys 
    1205                 1210                 1215             


Asp Gly  Glu Trp Val Leu Leu  Ser Thr Phe Leu 
    1220                 1225                 


<210>  5
<211>  1230
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of recombinant S protein

<400>  5

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Cys Val Asn Leu Arg Thr Arg Thr Gln Leu Pro Pro 
            20                  25                  30          


Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val 
        35                  40                  45              


Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe 
    50                  55                  60                  


Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn 
65                  70                  75                  80  


Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val 
                85                  90                  95      


Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe 
            100                 105                 110         


Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn 
        115                 120                 125             


Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp 
    130                 135                 140                 


Pro Phe Leu Asp Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu 
145                 150                 155                 160 


Ser Gly Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser 
                165                 170                 175     


Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn 
            180                 185                 190         


Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr 
        195                 200                 205             


Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe 
    210                 215                 220                 


Ser Val Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr 
225                 230                 235                 240 


Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly 
                245                 250                 255     


Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly 
            260                 265                 270         


Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr 
        275                 280                 285             


Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys 
    290                 295                 300                 


Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser 
305                 310                 315                 320 


Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile 
                325                 330                 335     


Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala 
            340                 345                 350         


Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp 
        355                 360                 365             


Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr 
    370                 375                 380                 


Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr 
385                 390                 395                 400 


Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro 
                405                 410                 415     


Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
            420                 425                 430         


Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys 
        435                 440                 445             


Val Gly Gly Asn Tyr Asn Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn 
    450                 455                 460                 


Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly 
465                 470                 475                 480 


Ser Lys Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu 
                485                 490                 495     


Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr 
            500                 505                 510         


Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val 
        515                 520                 525             


Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn 
    530                 535                 540                 


Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn 
545                 550                 555                 560 


Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr 
                565                 570                 575     


Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr 
            580                 585                 590         


Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr 
        595                 600                 605             


Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val 
    610                 615                 620                 


Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr 
625                 630                 635                 640 


Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly 
                645                 650                 655     


Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala 
            660                 665                 670         


Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Gly Ser 
        675                 680                 685             


Gly Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly 
    690                 695                 700                 


Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr 
705                 710                 715                 720 


Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr 
                725                 730                 735     


Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu 
            740                 745                 750         


Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn 
        755                 760                 765             


Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu 
    770                 775                 780                 


Val Phe Ala Gln Val Lys Gln Pro Asp Pro Ser Lys Pro Ser Ala Asn 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asn Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Val Glu Ala Glu 
                965                 970                 975     


Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr 
            980                 985                 990         


Tyr Val Thr Gln Gln Leu Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala 
        995                 1000                 1005             


Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
    1010                 1015                 1020             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1025                 1030                 1035             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1040                 1045                 1050             


Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1055                 1060                 1065             


His Asp  Gly Lys Ala His Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1070                 1075                 1080             


Asn Gly  Thr His Trp Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro 
    1085                 1090                 1095             


Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1100                 1105                 1110             


Val Val  Ile Gly Ile Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1115                 1120                 1125             


Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu Asp Lys  Tyr Phe Lys 
    1130                 1135                 1140             


Asn His  Thr Ser Pro Asp Val  Asp Leu Gly Asp Ile  Ser Gly Ile 
    1145                 1150                 1155             


Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu Ile Asp  Arg Leu Asn 
    1160                 1165                 1170             


Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu Ile Asp  Leu Gln Glu 
    1175                 1180                 1185             


Leu Gly  Lys Tyr Glu Gln Tyr  Ile Lys Trp Pro Ser  Ala Ile Gly 
    1190                 1195                 1200             


Gly Tyr  Ile Pro Glu Ala Pro  Arg Asp Gly Gln Ala  Tyr Val Arg 
    1205                 1210                 1215             


Lys Asp  Gly Glu Trp Val Leu  Leu Ser Thr Phe Leu  
    1220                 1225                 1230 


<210>  6
<211>  802
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Original sequence

<400>  6
agtactcata tatactttag attgatttaa aacttcattt ttaatttaaa aggatctagg       60

tgaagatcct ttttgataat ctcatgacca aaatccctta acgtgagttt tcgttccact      120

gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg agatcctttt tttctgcgcg      180

taatctgctg cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt ttgccggatc      240

aagagctacc aactcttttt ccgaaggtaa ctggcttcag cagagcgcag ataccaaata      300

ctgttcttct agtgtagccg tagttaggcc accacttcaa gaactctgta gcaccgccta      360

catacctcgc tctgctaatc ctgttaccag tggctgctgc cagtggcgat aagtcgtgtc      420

ttaccgggtt ggactcaaga cgatagttac cggataaggc gcagcggtcg ggctgaacgg      480

ggggttcgtg cacacagccc agcttggagc gaacgaccta caccgaactg agatacctac      540

agcgtgagct atgagaaagc gccacgcttc ccgaagggag aaaggcggac aggtatccgg      600

taagcggcag ggtcggaaca ggagagcgca cgagggagct tccaggggga aacgcctggt      660

atctttatag tcctgtcggg tttcgccacc tctgacttga gcgtcgattt ttgtgatgct      720

cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc ggccttttta cggtccctgg      780

ccttttgctg gccttttgct ca                                               802


<210>  7
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  T7 promoter

<400>  7
taatacgact cactataatg                                                   20


<210>  8
<211>  62
<212>  DNA
<213>  Artificial sequence

<220>
<223>  5'UTR

<400>  8
gtcccgcagt cggcgtccag cggctctgct tgttcgtgtg tgtgtcgttg caggccttat       60

tc                                                                      62


<210>  9
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  kozak sequence

<400>  9
agatctaccg gtggtaccgc cacc                                              24


<210>  10
<211>  89
<212>  DNA
<213>  Artificial sequence

<220>
<223>  3'UTR

<400>  10
agccaacacc ctgtctaaaa aacataaatt tctttaatca ttttgcctct tttctctgtg       60

cttcaattaa taaaaaatgg aaagaacct                                         89


<210>  11
<211>  3816
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA sequence of RBMRNA-Delta 1 vaccine

<400>  11
atgttcgtgt tcctggtgct gctgcctctg gtgagcagcc agtgcgtgaa tctgagaacc       60

agaacccagc tgcctcctgc ctacaccaat agcttcacca gaggagttta ttatcccgat      120

aaggtgttca gaagtagtgt attacatagt acccaggacc tgttcctacc tttcttcagt      180

aacgtgacct ggttccacgc catccacgtg agcggcacca atggcaccaa gagattcgac      240

aatcctgtgc tgcctttcaa tgacggcgtg tacttcgcca gcaccgagaa gagcaatatc      300

atcagaggct ggatcttcgg caccaccttg gattccaaga ctcagagcct gctgattgta      360

aacaacgcta caaatgtggt gatcaaggtg tgcgagttcc agttctgcaa tgaccctttc      420

ctggacgttt attatcataa gaacaacaag agctggatgg agagcggagt atattcgtcg      480

gctaataatt gcaccttcga gtacgtgagc cagcctttcc tgatggacct ggagggcaag      540

cagggcaatt tcaagaatct gagagagttc gtgttcaaga atatcgacgg ctacttcaag      600

atctacagca agcacacacc cattaatctg gtgagagacc tgcctcaggg cttcagcgtc      660

ctggagcctc tggtggacct gcctatcggc atcaatatca ccagattcca gaccctgctg      720

gccctgcaca gatcatatct tacaccaggc gattcgtcaa gcggttggac cgctggagct      780

gcggcatatt acgtgggcta cctgcagcct agaaccttcc tgctgaagta caatgagaat      840

ggtacgataa ccgacgcagt tgattgtgcc ctggaccctc tgagcgagac caagtgcacc      900

ctgaagagct tcaccgtgga gaagggcatc taccagacca gcaatttcag agtgcagcct      960

accgagagca tcgtgagatt ccctaatatc accaatctgt gccctttcgg cgaggtgttc     1020

aatgccacca gattcgccag cgtgtacgca tggaaccgca agcggataag caattgcgtg     1080

gccgactaca gcgtgctgta caatagcgcc agcttcagca ccttcaaatg ttatggtgtt     1140

tcgccaacaa agctgaatga cctgtgcttc accaatgtgt acgccgacag cttcgtgatc     1200

agaggcgacg aggtgagaca gatcgcgcca gggcagaccg gcaagatcgc cgactacaat     1260

tacaagctgc ctgacgactt caccggctgc gtgatcgcgt ggaactctaa caacctggac     1320

tcgaaagttg gaggcaatta caattaccgc tacagactgt tcagaaagag caatctgaag     1380

cctttcgaga gagacatcag caccgagatc taccaggccg gcagcaagcc gtgtaatggc     1440

gtggagggct tcaattgcta cttccctctg cagagctacg gcttccagcc taccaatggc     1500

gtgggctacc agccttacag agtggtggtg ctgagcttcg agctgctgca cgctcccgct     1560

accgtgtgcg gccctaagaa gagcaccaat ctggtgaaga ataagtgcgt gaatttcaat     1620

ttcaatggtc taactggaac gggcgtgctg accgagagca ataagaagtt tcttcccttt     1680

caacaattcg gcagagacat cgccgacacc acagatgctg taagagaccc tcagaccctg     1740

gagatcctgg acatcactcc gtgtagcttc ggcggcgtga gcgtgatcac accgggcacc     1800

aataccagca atcaggtggc cgtgctgtac cagggcgtga attgcaccga ggtgcctgtg     1860

gccatccacg ccgaccagct gactcccact tggagggtat attccacggg aagcaatgtg     1920

ttccagacca gagccggctg cctgatcggc gccgagcacg tgaataatag ctacgagtgc     1980

gacatcccta tcggcgccgg catctgcgcc agctaccaga cccagaccaa tagccgcggc     2040

ggcagcggca gcgtggccag ccagagcatc atcgcctaca ccatgagcct gggcgccgag     2100

aatagcgtgg cctacagcaa taatagcatc gccatcccta ccaatttcac catcagcgtg     2160

accaccgaaa tattaccagt ctccatgacc aagaccagcg tggactgcac catgtacatc     2220

tgcggcgaca gcaccgagtg cagcaatctg ctgctgcagt acggcagctt ctgcacccag     2280

ctgaatagag ccctgaccgg catcgccgtg gagcaggaca agaataccca ggaggtgttc     2340

gcccaggtga agcagatcta caagactccg ccgatcaagg acttcggcgg cttcaatttc     2400

agccaaatac tcccagatcc aagcaagcct agcgccaaca gcttcatcga ggacctgctg     2460

ttcaataagg tgaccctggc cgacgccggc ttcatcaagc agtacggcga ctgcctaggt     2520

gatattgcgg caagagacct gatctgcgcc cagaagttta acggtttgac agtactacct     2580

cctctgctga ccgacgagat gatagcacaa tatacgtcgg cattgctcgc tggcacgatc     2640

acatcgggct ggactttcgg cgccggagca gcgttgcaaa tccctttcgc catgcagatg     2700

gcctacagat tcaatggcat cggcgtgacc cagaatgtgc tgtacgagaa tcagaagctg     2760

atcgccaatc agttcaatag cgccatcggc aagatccagg acagcctgag cagcaccgcc     2820

agcgccctgg gcaagctgca gaacgtggtg aatcagaatg cccaggccct gaataccctg     2880

gtgaagcagc tgagcagcaa tttcggcgcc atcagtagtg tactcaacga catcctgagc     2940

agactggacc caccagaggc cgaggtgcaa attgatcgtc ttattactgg cagactgcag     3000

agcctgcaga cctacgtgac ccagcagctg atcagagccg ccgagatcag agccagcgcc     3060

aatctggccg ccaccaagat gagcgagtgc gtgctgggcc agagcaagag agtggacttc     3120

tgcggcaagg gctaccacct gatgagcttc cctcagagcg ctccacatgg cgtggtgttc     3180

ctgcacgtga cctacgtgcc tgcccaggag aagaatttca ccaccgcacc cgcaatctgc     3240

cacgacggca aggcccactt ccctagagag ggcgtgttcg tgagcaatgg cacccactgg     3300

ttcgtgaccc agagaaattt ctacgagcct cagatcatca ccaccgacaa taccttcgtg     3360

agcggcaatt gcgacgtggt gatcgggata gtcaataata ctgtctacga ccctctgcag     3420

cctgagctgg acagcttcaa ggaggagctg gacaagtact tcaagaatca caccagccct     3480

gacgtggacc tcggtgatat ttcgggaatc aatgccagcg tggtgaatat ccagaaggaa     3540

attgatcggc tcaacgaagt ggccaagaat ctgaatgaga gcctgatcga cctgcaggag     3600

ctgggcaagt acgagcagta catcaagtgg ccttggtaca tctggctggg cttcatcgcc     3660

ggcctgatcg ccatcgtgat ggtgaccatc atgctgtgct gcatgacctc ctgttgttcc     3720

tgtttgaaag ggtgttgttc gtgtgggtcc tgctgcaagt tcgacgagga cgacagcgag     3780

cctgtgctga agggcgtgaa gctgcactac acctaa                               3816


<210>  12
<211>  3690
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA sequence of RBMRNA-Delta 2 vaccine

<400>  12
atggactgga tctggagaat cctgttcctg gtgggggctg ccactggcgc ccatagccag       60

tgcgtgaatc tgagaaccag aacccagctg cctcctgcct acaccaatag cttcaccaga      120

ggagtttatt atcccgataa ggtgttcaga agtagtgtat tacatagtac ccaggacctg      180

ttcctacctt tcttcagtaa cgtgacctgg ttccacgcca tccacgtgag cggcaccaat      240

ggcaccaaga gattcgacaa tcctgtgctg cctttcaatg acggcgtgta cttcgccagc      300

accgagaaga gcaatatcat cagaggctgg atcttcggca ccaccttgga ttccaagact      360

cagagcctgc tgattgtaaa caacgctaca aatgtggtga tcaaggtgtg cgagttccag      420

ttctgcaatg accctttcct ggacgtttat tatcataaga acaacaagag ctggatggag      480

agcggagtat attcgtcggc taataattgc accttcgagt acgtgagcca gcctttcctg      540

atggacctgg agggcaagca gggcaatttc aagaatctga gagagttcgt gttcaagaat      600

atcgacggct acttcaagat ctacagcaag cacacaccca ttaatctggt gagagacctg      660

cctcagggct tcagcgtcct ggagcctctg gtggacctgc ctatcggcat caatatcacc      720

agattccaga ccctgctggc cctgcacaga tcatatctta caccaggcga ttcgtcaagc      780

ggttggaccg ctggagctgc ggcatattac gtgggctacc tgcagcctag aaccttcctg      840

ctgaagtaca atgagaatgg tacgataacc gacgcagttg attgtgccct ggaccctctg      900

agcgagacca agtgcaccct gaagagcttc accgtggaga agggcatcta ccagaccagc      960

aatttcagag tgcagcctac cgagagcatc gtgagattcc ctaatatcac caatctgtgc     1020

cctttcggcg aggtgttcaa tgccaccaga ttcgccagcg tgtacgcatg gaaccgcaag     1080

cggataagca attgcgtggc cgactacagc gtgctgtaca atagcgccag cttcagcacc     1140

ttcaaatgtt atggtgtttc gccaacaaag ctgaatgacc tgtgcttcac caatgtgtac     1200

gccgacagct tcgtgatcag aggcgacgag gtgagacaga tcgcgccagg gcagaccggc     1260

aagatcgccg actacaatta caagctgcct gacgacttca ccggctgcgt gatcgcgtgg     1320

aactctaaca acctggactc gaaagttgga ggcaattaca attaccgcta cagactgttc     1380

agaaagagca atctgaagcc tttcgagaga gacatcagca ccgagatcta ccaggccggc     1440

agcaagccgt gtaatggcgt ggagggcttc aattgctact tccctctgca gagctacggc     1500

ttccagccta ccaatggcgt gggctaccag ccttacagag tggtggtgct gagcttcgag     1560

ctgctgcacg ctcccgctac cgtgtgcggc cctaagaaga gcaccaatct ggtgaagaat     1620

aagtgcgtga atttcaattt caatggtcta actggaacgg gcgtgctgac cgagagcaat     1680

aagaagtttc ttccctttca acaattcggc agagacatcg ccgacaccac agatgctgta     1740

agagaccctc agaccctgga gatcctggac atcactccgt gtagcttcgg cggcgtgagc     1800

gtgatcacac cgggcaccaa taccagcaat caggtggccg tgctgtacca gggcgtgaat     1860

tgcaccgagg tgcctgtggc catccacgcc gaccagctga ctcccacttg gagggtatat     1920

tccacgggaa gcaatgtgtt ccagaccaga gccggctgcc tgatcggcgc cgagcacgtg     1980

aataatagct acgagtgcga catccctatc ggcgccggca tctgcgccag ctaccagacc     2040

cagaccaata gccctcgggg cagcggcagc gtggccagcc agagcatcat cgcctacacc     2100

atgagcctgg gcgccgagaa tagcgtggcc tacagcaata atagcatcgc catccctacc     2160

aatttcacca tcagcgtgac caccgaaata ttaccagtct ccatgaccaa gaccagcgtg     2220

gactgcacca tgtacatctg cggcgacagc accgagtgca gcaatctgct gctgcagtac     2280

ggcagcttct gcacccagct gaatagagcc ctgaccggca tcgccgtgga gcaggacaag     2340

aatacccagg aggtgttcgc ccaggtgaag cagccagatc caagcaagcc tagcgccaac     2400

agcttcatcg aggacctgct gttcaataag gtgaccctgg ccgacgccgg cttcatcaag     2460

cagtacggcg actgcctagg tgatattgcg gcaagagacc tgatctgcgc ccagaagttt     2520

aacggtttga cagtactacc tcctctgctg accgacgaga tgatagcaca atatacgtcg     2580

gcattgctcg ctggcacgat cacatcgggc tggactttcg gcgccggagc agcgttgcaa     2640

atccctttcg ccatgcagat ggcctacaga ttcaatggca tcggcgtgac ccagaatgtg     2700

ctgtacgaga atcagaagct gatcgccaat cagttcaata gcgccatcgg caagatccag     2760

gacagcctga gcagcaccgc cagcgccctg ggcaagctgc agaacgtggt gaatcagaat     2820

gcccaggccc tgaataccct ggtgaagcag ctgagcagca atttcggcgc catcagtagt     2880

gtactcaacg acatcctgag cagactggac ccgccggagg ccgaggtgca aattgatcgt     2940

cttattactg gcagactgca gagcctgcag acctacgtga cccagcagct gatcagagcc     3000

gccgagatca gagccagcgc caatctggcc gccaccaaga tgagcgagtg cgtgctgggc     3060

cagagcaaga gagtggactt ctgcggcaag ggctaccacc tgatgagctt ccctcagagc     3120

gctccacatg gcgtggtgtt cctgcacgtg acctacgtgc ctgcccagga gaagaatttc     3180

accaccgcac ccgcaatctg ccacgacggc aaggcccact tccctagaga gggcgtgttc     3240

gtgagcaatg gcacccactg gttcgtgacc cagagaaatt tctacgagcc tcagatcatc     3300

accaccgaca ataccttcgt gagcggcaat tgcgacgtgg tgatcgggat agtcaataat     3360

actgtctacg accctctgca gcctgagctg gacagcttca aggaggagct ggacaagtac     3420

ttcaagaatc acaccagccc tgacgtggac ctcggtgata tttcgggaat caatgccagc     3480

gtggtgaata tccagaagga aattgatcgg ctcaacgaag tggccaagaa tctgaatgag     3540

agcctgatcg acctgcagga gctgggcaag tacgagcagt acatcaagtg gcctagcgcc     3600

atcggcggct acatccccga ggcccccagg gacggccagg cctacgtgag gaaggacggc     3660

gagtgggtgc tgctgagcac cttcctgtga                                      3690


<210>  13
<211>  3816
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA sequence of RBMRNA-Delta 3 vaccine

<400>  13
atgttcgtgt tcctggtgct gctgcccctg gtgagcagcc agtgcgtgaa cctgagaacc       60

cggacccagc tgccaccagc ctacaccaac agcttcaccc ggggcgtcta ctaccccgac      120

aaggtgttcc ggagcagcgt cctgcacagc acccaggacc tgttcctgcc cttcttcagc      180

aacgtgacct ggttccacgc catccacgtg agcggcacca acggcaccaa gcggttcgac      240

aaccccgtgc tgcccttcaa cgacggcgtg tacttcgcca gcaccgagaa gagcaacatc      300

atccggggct ggatcttcgg caccaccctg gacagcaaga cccagagcct gctgatcgtg      360

aataacgcca ccaacgtggt gatcaaggtg tgcgagttcc agttctgcaa cgaccccttc      420

ctggacgtgt actaccacaa gaacaacaag agctggatgg agagcggagt gtacagcagc      480

gccaacaact gcaccttcga gtacgtgagc cagcccttcc tgatggacct ggagggcaag      540

cagggcaact tcaagaacct gcgggagttc gtgttcaaga acatcgacgg ctacttcaag      600

atctacagca agcacacccc aatcaacctg gtgcgggatc tgccccaggg cttctcagtc      660

ctggagcccc tggtggacct gcccatcggc atcaacatca cccggttcca gaccctgctg      720

gccctgcacc ggagctacct gaccccaggc gacagcagca gcgggtggac agcaggcgcg      780

gctgcttact acgtgggcta cctgcagccc cggaccttcc tgctgaagta caacgagaac      840

ggcaccatca ccgacgccgt ggactgcgcc ctggaccctc tgagcgagac caagtgcacc      900

ctgaagagct tcaccgtgga gaagggcatc taccagacca gcaacttccg ggtgcagccc      960

accgagagca tcgtgcggtt ccccaacatc accaacctgt gccccttcgg cgaggtgttc     1020

aacgccaccc ggttcgccag cgtgtacgcc tggaaccgga agcggatcag caactgcgtg     1080

gccgactaca gcgtgctgta caacagcgcc agcttcagca ccttcaagtg ctacggcgtg     1140

agccccacca agctgaacga cctgtgcttc accaacgtgt acgccgacag cttcgtgatc     1200

cgtggcgacg aggtgcggca gatcgcaccc ggccagacag gcaagatcgc cgactacaac     1260

tacaagctgc ccgacgactt caccggctgc gtgatcgcct ggaacagcaa caacctcgac     1320

agcaaggtgg gcggcaacta caactaccgc taccggctgt tccggaagag caacctgaag     1380

cccttcgagc gggacatcag caccgagatc taccaagccg gctccaagcc ttgcaacggc     1440

gtggagggct tcaactgcta cttccctctg cagagctacg gcttccagcc caccaacggc     1500

gtgggctacc agccctaccg ggtggtggtg ctgagcttcg agctgctgca cgccccagcc     1560

accgtgtgtg gccccaagaa gagcaccaac ctggtgaaga acaagtgcgt gaacttcaac     1620

ttcaacggcc ttaccggcac cggcgtgctg accgagagca acaagaaatt cctgcccttt     1680

cagcagttcg gccgggacat cgccgacacc accgacgctg tgcgggatcc ccagaccctg     1740

gagatcctgg acatcacccc ttgcagcttc ggcggcgtga gcgtgatcac cccaggcacc     1800

aacaccagca accaggtggc cgtgctgtac cagggcgtga actgcaccga ggtgcccgtg     1860

gccatccacg ccgaccagct gacacccacc tggcgggtct acagcaccgg cagcaacgtg     1920

ttccagaccc gggccggttg cctgatcggc gccgagcacg tgaacaacag ctacgagtgc     1980

gacatcccca tcggcgccgg catctgtgcc agctaccaga cccagaccaa ttcacgcggc     2040

ggcagcggca gcgtggccag ccagagcatc atcgcctaca ccatgagcct gggcgccgag     2100

aacagcgtgg cctacagcaa caacagcatc gccatcccca ccaacttcac catcagcgtg     2160

accaccgaga ttctgcccgt gagcatgacc aagaccagcg tggactgcac catgtacatc     2220

tgcggcgaca gcaccgagtg cagcaacctg ctgctgcagt acggcagctt ctgcacccag     2280

ctgaaccggg ccctgaccgg catcgccgtg gagcaggaca agaacaccca ggaggtgttc     2340

gcccaggtga agcagatcta caagacccct cccatcaagg acttcggcgg cttcaacttc     2400

agccagatcc tgcccgaccc cagcaagccc agcgccaaca gcttcatcga ggacctgctg     2460

ttcaacaagg tgaccctagc cgacgccggc ttcatcaagc agtacggcga ctgcctcggc     2520

gacatagccg cccgggacct gatctgcgcc cagaagttca acggcctgac cgtgctgcct     2580

cccctgctga ccgacgagat gatcgcccag tacaccagcg ccctgttagc cggaaccatc     2640

accagcggct ggactttcgg cgctggagcc gctctgcaga tccccttcgc catgcagatg     2700

gcctaccggt tcaacggcat cggcgtgacc cagaacgtgc tgtacgagaa ccagaagctg     2760

atcgccaacc agttcaacag cgccatcggc aagatccagg acagcctgag cagcaccgct     2820

agcgccctgg gcaagctgca gaacgtggtg aaccagaacg cccaggccct gaacaccctg     2880

gtgaagcagc tgagcagcaa cttcggcgcc atcagcagcg tgctgaacga catcctgagc     2940

cggctggacc ctcccgaggc cgaggtgcag atcgaccggc tgatcactgg ccggctgcag     3000

agcctgcaga cctacgtgac ccagcagctg atccgggccg ccgagattcg ggccagcgcc     3060

aacctggccg ccaccaagat gagcgagtgc gtgctgggcc agagcaagcg ggtggacttc     3120

tgcggcaagg gctaccacct gatgagcttt ccccagagcg caccccacgg agtggtgttc     3180

ctgcacgtga cctacgtgcc cgcccaggag aagaacttca ccaccgcccc agccatctgc     3240

cacgacggca aggcccactt tccccgggag ggcgtgttcg tgagcaacgg cacccactgg     3300

ttcgtgaccc agcggaactt ctacgagccc cagatcatca ccaccgacaa caccttcgtg     3360

agcggcaact gcgacgtggt gatcggcatc gtgaacaaca ccgtgtacga tcccctgcag     3420

cccgagctgg acagcttcaa ggaggagctg gacaagtact tcaagaatca caccagcccc     3480

gacgtggacc tgggcgacat cagcggcatc aacgccagcg tggtgaacat ccagaaggag     3540

atcgatcggc tgaacgaggt ggccaagaac ctgaacgaga gcctgatcga cctgcaggag     3600

ctgggcaagt acgagcagta catcaagtgg ccctggtaca tctggctggg cttcatcgcc     3660

ggcctgatcg ccatcgtgat ggtgaccatc atgctgtgct gcatgaccag ctgctgcagc     3720

tgcctgaagg gctgttgcag ctgcggcagc tgctgcaagt tcgacgagga cgacagcgag     3780

cccgtgctga agggcgtgaa gctgcactac acctga                               3816


<210>  14
<211>  4130
<212>  RNA
<213>  Artificial sequence

<220>
<223>  mRNA sequence of RBMRNA-Delta 1 vaccine

<400>  14
augagacaag cuugucccgc agucggcguc cagcggcucu gcuuguucgu gugugugucg       60

uugcaggccu uauucagauc uaccgguggu accgccacca uguucguguu ccuggugcug      120

cugccucugg ugagcagcca gugcgugaau cugagaacca gaacccagcu gccuccugcc      180

uacaccaaua gcuucaccag aggaguuuau uaucccgaua agguguucag aaguagugua      240

uuacauagua cccaggaccu guuccuaccu uucuucagua acgugaccug guuccacgcc      300

auccacguga gcggcaccaa uggcaccaag agauucgaca auccugugcu gccuuucaau      360

gacggcgugu acuucgccag caccgagaag agcaauauca ucagaggcug gaucuucggc      420

accaccuugg auuccaagac ucagagccug cugauuguaa acaacgcuac aaauguggug      480

aucaaggugu gcgaguucca guucugcaau gacccuuucc uggacguuua uuaucauaag      540

aacaacaaga gcuggaugga gagcggagua uauucgucgg cuaauaauug caccuucgag      600

uacgugagcc agccuuuccu gauggaccug gagggcaagc agggcaauuu caagaaucug      660

agagaguucg uguucaagaa uaucgacggc uacuucaaga ucuacagcaa gcacacaccc      720

auuaaucugg ugagagaccu gccucagggc uucagcgucc uggagccucu gguggaccug      780

ccuaucggca ucaauaucac cagauuccag acccugcugg cccugcacag aucauaucuu      840

acaccaggcg auucgucaag cgguuggacc gcuggagcug cggcauauua cgugggcuac      900

cugcagccua gaaccuuccu gcugaaguac aaugagaaug guacgauaac cgacgcaguu      960

gauugugccc uggacccucu gagcgagacc aagugcaccc ugaagagcuu caccguggag     1020

aagggcaucu accagaccag caauuucaga gugcagccua ccgagagcau cgugagauuc     1080

ccuaauauca ccaaucugug cccuuucggc gagguguuca augccaccag auucgccagc     1140

guguacgcau ggaaccgcaa gcggauaagc aauugcgugg ccgacuacag cgugcuguac     1200

aauagcgcca gcuucagcac cuucaaaugu uaugguguuu cgccaacaaa gcugaaugac     1260

cugugcuuca ccaaugugua cgccgacagc uucgugauca gaggcgacga ggugagacag     1320

aucgcgccag ggcagaccgg caagaucgcc gacuacaauu acaagcugcc ugacgacuuc     1380

accggcugcg ugaucgcgug gaacucuaac aaccuggacu cgaaaguugg aggcaauuac     1440

aauuaccgcu acagacuguu cagaaagagc aaucugaagc cuuucgagag agacaucagc     1500

accgagaucu accaggccgg cagcaagccg uguaauggcg uggagggcuu caauugcuac     1560

uucccucugc agagcuacgg cuuccagccu accaauggcg ugggcuacca gccuuacaga     1620

gugguggugc ugagcuucga gcugcugcac gcucccgcua ccgugugcgg cccuaagaag     1680

agcaccaauc uggugaagaa uaagugcgug aauuucaauu ucaauggucu aacuggaacg     1740

ggcgugcuga ccgagagcaa uaagaaguuu cuucccuuuc aacaauucgg cagagacauc     1800

gccgacacca cagaugcugu aagagacccu cagacccugg agauccugga caucacuccg     1860

uguagcuucg gcggcgugag cgugaucaca ccgggcacca auaccagcaa ucagguggcc     1920

gugcuguacc agggcgugaa uugcaccgag gugccugugg ccauccacgc cgaccagcug     1980

acucccacuu ggaggguaua uuccacggga agcaaugugu uccagaccag agccggcugc     2040

cugaucggcg ccgagcacgu gaauaauagc uacgagugcg acaucccuau cggcgccggc     2100

aucugcgcca gcuaccagac ccagaccaau agccgcggcg gcagcggcag cguggccagc     2160

cagagcauca ucgccuacac caugagccug ggcgccgaga auagcguggc cuacagcaau     2220

aauagcaucg ccaucccuac caauuucacc aucagcguga ccaccgaaau auuaccaguc     2280

uccaugacca agaccagcgu ggacugcacc auguacaucu gcggcgacag caccgagugc     2340

agcaaucugc ugcugcagua cggcagcuuc ugcacccagc ugaauagagc ccugaccggc     2400

aucgccgugg agcaggacaa gaauacccag gagguguucg cccaggugaa gcagaucuac     2460

aagacuccgc cgaucaagga cuucggcggc uucaauuuca gccaaauacu cccagaucca     2520

agcaagccua gcgccaacag cuucaucgag gaccugcugu ucaauaaggu gacccuggcc     2580

gacgccggcu ucaucaagca guacggcgac ugccuaggug auauugcggc aagagaccug     2640

aucugcgccc agaaguuuaa cgguuugaca guacuaccuc cucugcugac cgacgagaug     2700

auagcacaau auacgucggc auugcucgcu ggcacgauca caucgggcug gacuuucggc     2760

gccggagcag cguugcaaau cccuuucgcc augcagaugg ccuacagauu caauggcauc     2820

ggcgugaccc agaaugugcu guacgagaau cagaagcuga ucgccaauca guucaauagc     2880

gccaucggca agauccagga cagccugagc agcaccgcca gcgcccuggg caagcugcag     2940

aacgugguga aucagaaugc ccaggcccug aauacccugg ugaagcagcu gagcagcaau     3000

uucggcgcca ucaguagugu acucaacgac auccugagca gacuggaccc accagaggcc     3060

gaggugcaaa uugaucgucu uauuacuggc agacugcaga gccugcagac cuacgugacc     3120

cagcagcuga ucagagccgc cgagaucaga gccagcgcca aucuggccgc caccaagaug     3180

agcgagugcg ugcugggcca gagcaagaga guggacuucu gcggcaaggg cuaccaccug     3240

augagcuucc cucagagcgc uccacauggc gugguguucc ugcacgugac cuacgugccu     3300

gcccaggaga agaauuucac caccgcaccc gcaaucugcc acgacggcaa ggcccacuuc     3360

ccuagagagg gcguguucgu gagcaauggc acccacuggu ucgugaccca gagaaauuuc     3420

uacgagccuc agaucaucac caccgacaau accuucguga gcggcaauug cgacguggug     3480

aucgggauag ucaauaauac ugucuacgac ccucugcagc cugagcugga cagcuucaag     3540

gaggagcugg acaaguacuu caagaaucac accagcccug acguggaccu cggugauauu     3600

ucgggaauca augccagcgu ggugaauauc cagaaggaaa uugaucggcu caacgaagug     3660

gccaagaauc ugaaugagag ccugaucgac cugcaggagc ugggcaagua cgagcaguac     3720

aucaaguggc cuugguacau cuggcugggc uucaucgccg gccugaucgc caucgugaug     3780

gugaccauca ugcugugcug caugaccucc uguuguuccu guuugaaagg guguuguucg     3840

uguggguccu gcugcaaguu cgacgaggac gacagcgagc cugugcugaa gggcgugaag     3900

cugcacuaca ccuaacucga gacuaguagc caacacccug ucuaaaaaac auaaauuucu     3960

uuaaucauuu ugccucuuuu cucugugcuu caauuaauaa aaaauggaaa gaaccuaaaa     4020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                4130


<210>  15
<211>  4004
<212>  RNA
<213>  Artificial sequence

<220>
<223>  mRNA sequence of RBMRNA-Delta 2 vaccine

<400>  15
augagacaag cuugucccgc agucggcguc cagcggcucu gcuuguucgu gugugugucg       60

uugcaggccu uauucagauc uaccgguggu accgccacca uggacuggau cuggagaauc      120

cuguuccugg ugggggcugc cacuggcgcc cauagccagu gcgugaaucu gagaaccaga      180

acccagcugc cuccugccua caccaauagc uucaccagag gaguuuauua ucccgauaag      240

guguucagaa guaguguauu acauaguacc caggaccugu uccuaccuuu cuucaguaac      300

gugaccuggu uccacgccau ccacgugagc ggcaccaaug gcaccaagag auucgacaau      360

ccugugcugc cuuucaauga cggcguguac uucgccagca ccgagaagag caauaucauc      420

agaggcugga ucuucggcac caccuuggau uccaagacuc agagccugcu gauuguaaac      480

aacgcuacaa auguggugau caaggugugc gaguuccagu ucugcaauga cccuuuccug      540

gacguuuauu aucauaagaa caacaagagc uggauggaga gcggaguaua uucgucggcu      600

aauaauugca ccuucgagua cgugagccag ccuuuccuga uggaccugga gggcaagcag      660

ggcaauuuca agaaucugag agaguucgug uucaagaaua ucgacggcua cuucaagauc      720

uacagcaagc acacacccau uaaucuggug agagaccugc cucagggcuu cagcguccug      780

gagccucugg uggaccugcc uaucggcauc aauaucacca gauuccagac ccugcuggcc      840

cugcacagau cauaucuuac accaggcgau ucgucaagcg guuggaccgc uggagcugcg      900

gcauauuacg ugggcuaccu gcagccuaga accuuccugc ugaaguacaa ugagaauggu      960

acgauaaccg acgcaguuga uugugcccug gacccucuga gcgagaccaa gugcacccug     1020

aagagcuuca ccguggagaa gggcaucuac cagaccagca auuucagagu gcagccuacc     1080

gagagcaucg ugagauuccc uaauaucacc aaucugugcc cuuucggcga gguguucaau     1140

gccaccagau ucgccagcgu guacgcaugg aaccgcaagc ggauaagcaa uugcguggcc     1200

gacuacagcg ugcuguacaa uagcgccagc uucagcaccu ucaaauguua ugguguuucg     1260

ccaacaaagc ugaaugaccu gugcuucacc aauguguacg ccgacagcuu cgugaucaga     1320

ggcgacgagg ugagacagau cgcgccaggg cagaccggca agaucgccga cuacaauuac     1380

aagcugccug acgacuucac cggcugcgug aucgcgugga acucuaacaa ccuggacucg     1440

aaaguuggag gcaauuacaa uuaccgcuac agacuguuca gaaagagcaa ucugaagccu     1500

uucgagagag acaucagcac cgagaucuac caggccggca gcaagccgug uaauggcgug     1560

gagggcuuca auugcuacuu cccucugcag agcuacggcu uccagccuac caauggcgug     1620

ggcuaccagc cuuacagagu gguggugcug agcuucgagc ugcugcacgc ucccgcuacc     1680

gugugcggcc cuaagaagag caccaaucug gugaagaaua agugcgugaa uuucaauuuc     1740

aauggucuaa cuggaacggg cgugcugacc gagagcaaua agaaguuucu ucccuuucaa     1800

caauucggca gagacaucgc cgacaccaca gaugcuguaa gagacccuca gacccuggag     1860

auccuggaca ucacuccgug uagcuucggc ggcgugagcg ugaucacacc gggcaccaau     1920

accagcaauc agguggccgu gcuguaccag ggcgugaauu gcaccgaggu gccuguggcc     1980

auccacgccg accagcugac ucccacuugg aggguauauu ccacgggaag caauguguuc     2040

cagaccagag ccggcugccu gaucggcgcc gagcacguga auaauagcua cgagugcgac     2100

aucccuaucg gcgccggcau cugcgccagc uaccagaccc agaccaauag cccucggggc     2160

agcggcagcg uggccagcca gagcaucauc gccuacacca ugagccuggg cgccgagaau     2220

agcguggccu acagcaauaa uagcaucgcc aucccuacca auuucaccau cagcgugacc     2280

accgaaauau uaccagucuc caugaccaag accagcgugg acugcaccau guacaucugc     2340

ggcgacagca ccgagugcag caaucugcug cugcaguacg gcagcuucug cacccagcug     2400

aauagagccc ugaccggcau cgccguggag caggacaaga auacccagga gguguucgcc     2460

caggugaagc agccagaucc aagcaagccu agcgccaaca gcuucaucga ggaccugcug     2520

uucaauaagg ugacccuggc cgacgccggc uucaucaagc aguacggcga cugccuaggu     2580

gauauugcgg caagagaccu gaucugcgcc cagaaguuua acgguuugac aguacuaccu     2640

ccucugcuga ccgacgagau gauagcacaa uauacgucgg cauugcucgc uggcacgauc     2700

acaucgggcu ggacuuucgg cgccggagca gcguugcaaa ucccuuucgc caugcagaug     2760

gccuacagau ucaauggcau cggcgugacc cagaaugugc uguacgagaa ucagaagcug     2820

aucgccaauc aguucaauag cgccaucggc aagauccagg acagccugag cagcaccgcc     2880

agcgcccugg gcaagcugca gaacguggug aaucagaaug cccaggcccu gaauacccug     2940

gugaagcagc ugagcagcaa uuucggcgcc aucaguagug uacucaacga cauccugagc     3000

agacuggacc cgccggaggc cgaggugcaa auugaucguc uuauuacugg cagacugcag     3060

agccugcaga ccuacgugac ccagcagcug aucagagccg ccgagaucag agccagcgcc     3120

aaucuggccg ccaccaagau gagcgagugc gugcugggcc agagcaagag aguggacuuc     3180

ugcggcaagg gcuaccaccu gaugagcuuc ccucagagcg cuccacaugg cgugguguuc     3240

cugcacguga ccuacgugcc ugcccaggag aagaauuuca ccaccgcacc cgcaaucugc     3300

cacgacggca aggcccacuu cccuagagag ggcguguucg ugagcaaugg cacccacugg     3360

uucgugaccc agagaaauuu cuacgagccu cagaucauca ccaccgacaa uaccuucgug     3420

agcggcaauu gcgacguggu gaucgggaua gucaauaaua cugucuacga cccucugcag     3480

ccugagcugg acagcuucaa ggaggagcug gacaaguacu ucaagaauca caccagcccu     3540

gacguggacc ucggugauau uucgggaauc aaugccagcg uggugaauau ccagaaggaa     3600

auugaucggc ucaacgaagu ggccaagaau cugaaugaga gccugaucga ccugcaggag     3660

cugggcaagu acgagcagua caucaagugg ccuagcgcca ucggcggcua cauccccgag     3720

gcccccaggg acggccaggc cuacgugagg aaggacggcg agugggugcu gcugagcacc     3780

uuccugugac ucgagacuag uagccaacac ccugucuaaa aaacauaaau uucuuuaauc     3840

auuuugccuc uuuucucugu gcuucaauua auaaaaaaug gaaagaaccu aaaaaaaaaa     3900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                      4004


<210>  16
<211>  4130
<212>  RNA
<213>  Artificial sequence

<220>
<223>  mRNA sequence of RBMRNA-Delta 3 vaccine

<400>  16
augagacaag cuugucccgc agucggcguc cagcggcucu gcuuguucgu gugugugucg       60

uugcaggccu uauucagauc uaccgguggu accgccacca uguucguguu ccuggugcug      120

cugccccugg ugagcagcca gugcgugaac cugagaaccc ggacccagcu gccaccagcc      180

uacaccaaca gcuucacccg gggcgucuac uaccccgaca agguguuccg gagcagcguc      240

cugcacagca cccaggaccu guuccugccc uucuucagca acgugaccug guuccacgcc      300

auccacguga gcggcaccaa cggcaccaag cgguucgaca accccgugcu gcccuucaac      360

gacggcgugu acuucgccag caccgagaag agcaacauca uccggggcug gaucuucggc      420

accacccugg acagcaagac ccagagccug cugaucguga auaacgccac caacguggug      480

aucaaggugu gcgaguucca guucugcaac gaccccuucc uggacgugua cuaccacaag      540

aacaacaaga gcuggaugga gagcggagug uacagcagcg ccaacaacug caccuucgag      600

uacgugagcc agcccuuccu gauggaccug gagggcaagc agggcaacuu caagaaccug      660

cgggaguucg uguucaagaa caucgacggc uacuucaaga ucuacagcaa gcacacccca      720

aucaaccugg ugcgggaucu gccccagggc uucucagucc uggagccccu gguggaccug      780

cccaucggca ucaacaucac ccgguuccag acccugcugg cccugcaccg gagcuaccug      840

accccaggcg acagcagcag cggguggaca gcaggcgcgg cugcuuacua cgugggcuac      900

cugcagcccc ggaccuuccu gcugaaguac aacgagaacg gcaccaucac cgacgccgug      960

gacugcgccc uggacccucu gagcgagacc aagugcaccc ugaagagcuu caccguggag     1020

aagggcaucu accagaccag caacuuccgg gugcagccca ccgagagcau cgugcgguuc     1080

cccaacauca ccaaccugug ccccuucggc gagguguuca acgccacccg guucgccagc     1140

guguacgccu ggaaccggaa gcggaucagc aacugcgugg ccgacuacag cgugcuguac     1200

aacagcgcca gcuucagcac cuucaagugc uacggcguga gccccaccaa gcugaacgac     1260

cugugcuuca ccaacgugua cgccgacagc uucgugaucc guggcgacga ggugcggcag     1320

aucgcacccg gccagacagg caagaucgcc gacuacaacu acaagcugcc cgacgacuuc     1380

accggcugcg ugaucgccug gaacagcaac aaccucgaca gcaagguggg cggcaacuac     1440

aacuaccgcu accggcuguu ccggaagagc aaccugaagc ccuucgagcg ggacaucagc     1500

accgagaucu accaagccgg cuccaagccu ugcaacggcg uggagggcuu caacugcuac     1560

uucccucugc agagcuacgg cuuccagccc accaacggcg ugggcuacca gcccuaccgg     1620

gugguggugc ugagcuucga gcugcugcac gccccagcca ccgugugugg ccccaagaag     1680

agcaccaacc uggugaagaa caagugcgug aacuucaacu ucaacggccu uaccggcacc     1740

ggcgugcuga ccgagagcaa caagaaauuc cugcccuuuc agcaguucgg ccgggacauc     1800

gccgacacca ccgacgcugu gcgggauccc cagacccugg agauccugga caucaccccu     1860

ugcagcuucg gcggcgugag cgugaucacc ccaggcacca acaccagcaa ccagguggcc     1920

gugcuguacc agggcgugaa cugcaccgag gugcccgugg ccauccacgc cgaccagcug     1980

acacccaccu ggcgggucua cagcaccggc agcaacgugu uccagacccg ggccgguugc     2040

cugaucggcg ccgagcacgu gaacaacagc uacgagugcg acauccccau cggcgccggc     2100

aucugugcca gcuaccagac ccagaccaau ucacgcggcg gcagcggcag cguggccagc     2160

cagagcauca ucgccuacac caugagccug ggcgccgaga acagcguggc cuacagcaac     2220

aacagcaucg ccauccccac caacuucacc aucagcguga ccaccgagau ucugcccgug     2280

agcaugacca agaccagcgu ggacugcacc auguacaucu gcggcgacag caccgagugc     2340

agcaaccugc ugcugcagua cggcagcuuc ugcacccagc ugaaccgggc ccugaccggc     2400

aucgccgugg agcaggacaa gaacacccag gagguguucg cccaggugaa gcagaucuac     2460

aagaccccuc ccaucaagga cuucggcggc uucaacuuca gccagauccu gcccgacccc     2520

agcaagccca gcgccaacag cuucaucgag gaccugcugu ucaacaaggu gacccuagcc     2580

gacgccggcu ucaucaagca guacggcgac ugccucggcg acauagccgc ccgggaccug     2640

aucugcgccc agaaguucaa cggccugacc gugcugccuc cccugcugac cgacgagaug     2700

aucgcccagu acaccagcgc ccuguuagcc ggaaccauca ccagcggcug gacuuucggc     2760

gcuggagccg cucugcagau ccccuucgcc augcagaugg ccuaccgguu caacggcauc     2820

ggcgugaccc agaacgugcu guacgagaac cagaagcuga ucgccaacca guucaacagc     2880

gccaucggca agauccagga cagccugagc agcaccgcua gcgcccuggg caagcugcag     2940

aacgugguga accagaacgc ccaggcccug aacacccugg ugaagcagcu gagcagcaac     3000

uucggcgcca ucagcagcgu gcugaacgac auccugagcc ggcuggaccc ucccgaggcc     3060

gaggugcaga ucgaccggcu gaucacuggc cggcugcaga gccugcagac cuacgugacc     3120

cagcagcuga uccgggccgc cgagauucgg gccagcgcca accuggccgc caccaagaug     3180

agcgagugcg ugcugggcca gagcaagcgg guggacuucu gcggcaaggg cuaccaccug     3240

augagcuuuc cccagagcgc accccacgga gugguguucc ugcacgugac cuacgugccc     3300

gcccaggaga agaacuucac caccgcccca gccaucugcc acgacggcaa ggcccacuuu     3360

ccccgggagg gcguguucgu gagcaacggc acccacuggu ucgugaccca gcggaacuuc     3420

uacgagcccc agaucaucac caccgacaac accuucguga gcggcaacug cgacguggug     3480

aucggcaucg ugaacaacac cguguacgau ccccugcagc ccgagcugga cagcuucaag     3540

gaggagcugg acaaguacuu caagaaucac accagccccg acguggaccu gggcgacauc     3600

agcggcauca acgccagcgu ggugaacauc cagaaggaga ucgaucggcu gaacgaggug     3660

gccaagaacc ugaacgagag ccugaucgac cugcaggagc ugggcaagua cgagcaguac     3720

aucaaguggc ccugguacau cuggcugggc uucaucgccg gccugaucgc caucgugaug     3780

gugaccauca ugcugugcug caugaccagc ugcugcagcu gccugaaggg cuguugcagc     3840

ugcggcagcu gcugcaaguu cgacgaggac gacagcgagc ccgugcugaa gggcgugaag     3900

cugcacuaca ccugacucga gacuaguagc caacacccug ucuaaaaaac auaaauuucu     3960

uuaaucauuu ugccucuuuu cucugugcuu caauuaauaa aaaauggaaa gaaccuaaaa     4020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                4130


<210>  17
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  signal sequence

<400>  17

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser 
            


<210>  18
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of trimer domain

<400>  18

Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
1               5                   10                  15      


Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
            20                  25          


<210>  19
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker sequence

<400>  19

Ser Ala Ile Gly 
1               


<210>  20
<211>  1270
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of recombinant S protein

<400>  20

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Val Ile Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro 
65                  70                  75                  80  


Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Ile Glu Lys Ser 
                85                  90                  95      


Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr 
            100                 105                 110         


Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val 
        115                 120                 125             


Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Asp His Lys Asn Asn 
    130                 135                 140                 


Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn 
145                 150                 155                 160 


Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly 
                165                 170                 175     


Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile 
            180                 185                 190         


Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Ile Val Arg 
        195                 200                 205             


Glu Pro Glu Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val 
    210                 215                 220                 


Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Asp 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Leu 
        355                 360                 365             


Ala Pro Phe Phe Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Lys Leu Asp Ser Lys Val Ser Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Asn Lys Pro Cys Asn Gly Val 
465                 470                 475                 480 


Ala Gly Phe Asn Cys Tyr Phe Pro Leu Arg Ser Tyr Ser Phe Arg Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly His Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Lys 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu Tyr Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Lys Ser His Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Lys Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Tyr Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Lys Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn His Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Lys Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Phe Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1250                 1255                 1260             


Gly Val  Lys Leu His Tyr Thr  
    1265                 1270 


<210>  21
<211>  1270
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of recombinant S protein

<400>  21

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Val Ile Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro 
65                  70                  75                  80  


Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Ile Glu Lys Ser 
                85                  90                  95      


Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr 
            100                 105                 110         


Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val 
        115                 120                 125             


Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Asp His Lys Asn Asn 
    130                 135                 140                 


Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn 
145                 150                 155                 160 


Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly 
                165                 170                 175     


Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile 
            180                 185                 190         


Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Ile Val Arg 
        195                 200                 205             


Glu Pro Glu Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val 
    210                 215                 220                 


Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Asp 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Leu 
        355                 360                 365             


Ala Pro Phe Phe Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Lys Leu Asp Ser Lys Val Ser Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Asn Lys Pro Cys Asn Gly Val 
465                 470                 475                 480 


Ala Gly Phe Asn Cys Tyr Phe Pro Leu Arg Ser Tyr Ser Phe Arg Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly His Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Lys 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu Tyr Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Lys Ser His Gly Gly Ser Gly Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Lys Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Tyr Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Ala Asn Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Lys Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn His Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Lys Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Phe Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1250                 1255                 1260             


Gly Val  Lys Leu His Tyr Thr  
    1265                 1270 


<210>  22
<211>  1270
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of recombinant S protein

<400>  22

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Val Ile Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro 
65                  70                  75                  80  


Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Ile Glu Lys Ser 
                85                  90                  95      


Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr 
            100                 105                 110         


Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val 
        115                 120                 125             


Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Asp His Lys Asn Asn 
    130                 135                 140                 


Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn 
145                 150                 155                 160 


Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly 
                165                 170                 175     


Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile 
            180                 185                 190         


Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Ile Val Arg 
        195                 200                 205             


Glu Pro Glu Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val 
    210                 215                 220                 


Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Asp 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Leu 
        355                 360                 365             


Ala Pro Phe Phe Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Lys Leu Asp Ser Lys Val Ser Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Asn Lys Pro Cys Asn Gly Val 
465                 470                 475                 480 


Ala Gly Phe Asn Cys Tyr Phe Pro Leu Arg Ser Tyr Ser Phe Arg Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly His Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Lys 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu Tyr Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Lys Ser His Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Lys Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Tyr Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Lys Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn His Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Lys Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Phe Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1250                 1255                 1260             


Gly Val  Lys Leu His Tyr Thr  
    1265                 1270 


<210>  23
<211>  1270
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of recombinant S protein

<400>  23

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Val Ile Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro 
65                  70                  75                  80  


Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Ile Glu Lys Ser 
                85                  90                  95      


Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr 
            100                 105                 110         


Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val 
        115                 120                 125             


Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Asp His Lys Asn Asn 
    130                 135                 140                 


Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn 
145                 150                 155                 160 


Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly 
                165                 170                 175     


Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile 
            180                 185                 190         


Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Ile Val Arg 
        195                 200                 205             


Glu Pro Glu Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val 
    210                 215                 220                 


Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Asp 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Leu 
        355                 360                 365             


Ala Pro Phe Phe Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Lys Leu Asp Ser Lys Val Ser Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Asn Lys Pro Cys Asn Gly Val 
465                 470                 475                 480 


Ala Gly Phe Asn Cys Tyr Phe Pro Leu Arg Ser Tyr Ser Phe Arg Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly His Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Lys 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu Tyr Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Lys Ser His Gly Gly Ser Gly Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Lys Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Tyr Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Lys Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn His Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Lys Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Phe Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1250                 1255                 1260             


Gly Val  Lys Leu His Tyr Thr  
    1265                 1270 


<210>  24
<211>  1270
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of recombinant S protein

<400>  24

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Val Ile Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro 
65                  70                  75                  80  


Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Ile Glu Lys Ser 
                85                  90                  95      


Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr 
            100                 105                 110         


Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val 
        115                 120                 125             


Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Asp His Lys Asn Asn 
    130                 135                 140                 


Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn 
145                 150                 155                 160 


Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly 
                165                 170                 175     


Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile 
            180                 185                 190         


Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Ile Val Arg 
        195                 200                 205             


Glu Pro Glu Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val 
    210                 215                 220                 


Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Asp 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Leu 
        355                 360                 365             


Ala Pro Phe Phe Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Lys Leu Asp Ser Lys Val Ser Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Asn Lys Pro Cys Asn Gly Val 
465                 470                 475                 480 


Ala Gly Phe Asn Cys Tyr Phe Pro Leu Arg Ser Tyr Ser Phe Arg Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly His Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Lys 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu Tyr Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Lys Ser His Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Lys Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Tyr Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Ala Asn Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Lys Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn His Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Lys Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Phe Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1250                 1255                 1260             


Gly Val  Lys Leu His Tyr Thr  
    1265                 1270 


<210>  25
<211>  1270
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of recombinant S protein

<400>  25

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Val Ile Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro 
65                  70                  75                  80  


Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Ile Glu Lys Ser 
                85                  90                  95      


Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr 
            100                 105                 110         


Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val 
        115                 120                 125             


Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Asp His Lys Asn Asn 
    130                 135                 140                 


Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn 
145                 150                 155                 160 


Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly 
                165                 170                 175     


Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile 
            180                 185                 190         


Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Ile Val Arg 
        195                 200                 205             


Glu Pro Glu Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val 
    210                 215                 220                 


Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Asp 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Leu 
        355                 360                 365             


Ala Pro Phe Phe Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Lys Leu Asp Ser Lys Val Ser Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Asn Lys Pro Cys Asn Gly Val 
465                 470                 475                 480 


Ala Gly Phe Asn Cys Tyr Phe Pro Leu Arg Ser Tyr Ser Phe Arg Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly His Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Lys 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu Tyr Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Lys Ser His Gly Gly Ser Gly Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Lys Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Tyr Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Ala Asn Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Lys Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn His Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Lys Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Phe Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1250                 1255                 1260             


Gly Val  Lys Leu His Tyr Thr  
    1265                 1270 


<210>  26
<211>  3813
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA sequence of RBMRNA-Omicron vaccine

<400>  26
atgttcgtgt tcctggtgct gctgcctctg gtgagcagcc agtgcgtgaa tctgaccacc       60

agaacccagc tgcctcctgc ctacaccaat agcttcacca gaggagttta ttatcccgat      120

aaggtgttca gaagtagtgt attacatagt acccaggacc tgttcctacc tttcttcagt      180

aacgtgacct ggttccacgt catcagcggc accaatggca ccaagagatt cgacaatcct      240

gtgctgcctt tcaatgacgg cgtgtacttc gccagcatcg agaagagcaa tatcatcaga      300

ggctggatct tcggcaccac cttggattcc aagactcaga gcctgctgat tgtaaacaac      360

gctacaaatg tggtgatcaa ggtgtgcgag ttccagttct gcaatgaccc tttcctggac      420

cataagaaca acaagagctg gatggagagc gagttccgcg tatattcgtc ggctaataat      480

tgcaccttcg agtacgtgag ccagcctttc ctgatggacc tggagggcaa gcagggcaat      540

ttcaagaatc tgagagagtt cgtgttcaag aatatcgacg gctacttcaa gatctacagc      600

aagcacacac ccattatcgt gagagagccg gaggacctgc ctcagggctt cagcgccctg      660

gagcctctgg tggacctgcc tatcggcatc aatatcacca gattccagac cctgctggcc      720

ctgcacagat catatcttac accaggcgat tcgtcaagcg gttggaccgc tggagctgcg      780

gcatattacg tgggctacct gcagcctaga accttcctgc tgaagtacaa tgagaatggt      840

acgataaccg acgcagttga ttgtgccctg gaccctctga gcgagaccaa gtgcaccctg      900

aagagcttca ccgtggagaa gggcatctac cagaccagca atttcagagt gcagcctacc      960

gagagcatcg tgagattccc taatatcacc aatctgtgcc ctttcgacga ggtgttcaat     1020

gccaccagat tcgccagcgt gtacgcatgg aaccgcaagc ggataagcaa ttgcgtggcc     1080

gactacagcg tgctgtacaa tctggcccca ttcttcacct tcaaatgtta tggtgtttcg     1140

ccaacaaagc tgaatgacct gtgcttcacc aatgtgtacg ccgacagctt cgtgatcaga     1200

ggcgacgagg tgagacagat cgcgccaggg cagaccggca acatcgccga ctacaattac     1260

aagctgcctg acgacttcac cggctgcgtg atcgcgtgga actctaacaa gctggactcg     1320

aaagtttcag gcaattacaa ttacctgtac agactgttca gaaagagcaa tctgaagcct     1380

ttcgagagag acatcagcac cgagatctac caggccggca acaagccgtg taatggcgtg     1440

gcgggcttca attgctactt ccctctgcgc agctacagct tccggcctac ctacggcgtg     1500

ggccaccagc cttacagagt ggtggtgctg agcttcgagc tgctgcacgc tcccgctacc     1560

gtgtgcggcc ctaagaagag caccaatctg gtgaagaata agtgcgtgaa tttcaatttc     1620

aatggtctaa agggaacggg cgtgctgacc gagagcaata agaagtttct tccctttcaa     1680

caattcggca gagacatcgc cgacaccaca gatgctgtaa gagaccctca gaccctggag     1740

atcctggaca tcactccgtg tagcttcggc ggcgtgagcg tgatcacacc gggcaccaat     1800

accagcaatc aggtggccgt gctgtaccag ggcgtgaatt gcaccgaggt gcctgtggcc     1860

atccacgccg accagctgac tcccacttgg agggtatatt ccacgggaag caatgtgttc     1920

cagaccagag ccggctgcct gatcggcgcc gagtacgtga ataatagcta cgagtgcgac     1980

atccctatcg gcgccggcat ctgcgccagc taccagaccc agaccaagag ccacggcggc     2040

agcggcagcg tggccagcca gagcatcatc gcctacacca tgagcctggg cgccgagaat     2100

agcgtggcct acagcaataa tagcatcgcc atccctacca atttcaccat cagcgtgacc     2160

accgaaatat taccagtctc catgaccaag accagcgtgg actgcaccat gtacatctgc     2220

ggcgacagca ccgagtgcag caatctgctg ctgcagtacg gcagcttctg cacccagctg     2280

aagagagccc tgaccggcat cgccgtggag caggacaaga atacccagga ggtgttcgcc     2340

caggtgaagc agatctacaa gactccgccg atcaagtact tcggcggctt caatttcagc     2400

caaatactcc cagatccaag caagcctagc gccaacagct tcatcgagga cctgctgttc     2460

aataaggtga ccctggccga cgccggcttc atcaagcagt acggcgactg cctaggtgat     2520

attgcggcaa gagacctgat ctgcgcccag aagtttaagg gtttgacagt actacctcct     2580

ctgctgaccg acgagatgat agcacaatat acgtcggcat tgctcgctgg cacgatcaca     2640

tcgggctgga ctttcggcgc cggagcagcg ttgcaaatcc ctttcgccat gcagatggcc     2700

tacagattca atggcatcgg cgtgacccag aatgtgctgt acgagaatca gaagctgatc     2760

gccaatcagt tcaatagcgc catcggcaag atccaggaca gcctgagcag caccgccagc     2820

gccctgggca agctgcagga cgtggtgaat cacaatgccc aggccctgaa taccctggtg     2880

aagcagctga gcagcaagtt cggcgccatc agtagtgtac tcaacgacat cttcagcaga     2940

ctggacccac cagaggccga ggtgcaaatt gatcgtctta ttactggcag actgcagagc     3000

ctgcagacct acgtgaccca gcagctgatc agagccgccg agatcagagc cagcgccaat     3060

ctggccgcca ccaagatgag cgagtgcgtg ctgggccaga gcaagagagt ggacttctgc     3120

ggcaagggct accacctgat gagcttccct cagagcgctc cacatggcgt ggtgttcctg     3180

cacgtgacct acgtgcctgc ccaggagaag aatttcacca ccgcacccgc aatctgccac     3240

gacggcaagg cccacttccc tagagagggc gtgttcgtga gcaatggcac ccactggttc     3300

gtgacccaga gaaatttcta cgagcctcag atcatcacca ccgacaatac cttcgtgagc     3360

ggcaattgcg acgtggtgat cgggatagtc aataatactg tctacgaccc tctgcagcct     3420

gagctggaca gcttcaagga ggagctggac aagtacttca agaatcacac cagccctgac     3480

gtggacctcg gtgatatttc gggaatcaat gccagcgtgg tgaatatcca gaaggaaatt     3540

gatcggctca acgaagtggc caagaatctg aatgagagcc tgatcgacct gcaggagctg     3600

ggcaagtacg agcagtacat caagtggcct tggtacatct ggctgggctt catcgccggc     3660

ctgatcgcca tcgtgatggt gaccatcatg ctgtgctgca tgacctcctg ttgttcctgt     3720

ttgaaagggt gttgttcgtg tgggtcctgc tgcaagttcg acgaggacga cagcgagcct     3780

gtgctgaagg gcgtgaagct gcactacacc taa                                  3813


<210>  27
<211>  4127
<212>  RNA
<213>  Artificial sequence

<220>
<223>  mRNA sequence of RBMRNA-Omicron vaccine

<400>  27
augagacaag cuugucccgc agucggcguc cagcggcucu gcuuguucgu gugugugucg       60

uugcaggccu uauucagauc uaccgguggu accgccacca uguucguguu ccuggugcug      120

cugccucugg ugagcagcca gugcgugaau cugaccacca gaacccagcu gccuccugcc      180

uacaccaaua gcuucaccag aggaguuuau uaucccgaua agguguucag aaguagugua      240

uuacauagua cccaggaccu guuccuaccu uucuucagua acgugaccug guuccacguc      300

aucagcggca ccaauggcac caagagauuc gacaauccug ugcugccuuu caaugacggc      360

guguacuucg ccagcaucga gaagagcaau aucaucagag gcuggaucuu cggcaccacc      420

uuggauucca agacucagag ccugcugauu guaaacaacg cuacaaaugu ggugaucaag      480

gugugcgagu uccaguucug caaugacccu uuccuggacc auaagaacaa caagagcugg      540

auggagagcg aguuccgcgu auauucgucg gcuaauaauu gcaccuucga guacgugagc      600

cagccuuucc ugauggaccu ggagggcaag cagggcaauu ucaagaaucu gagagaguuc      660

guguucaaga auaucgacgg cuacuucaag aucuacagca agcacacacc cauuaucgug      720

agagagccgg aggaccugcc ucagggcuuc agcgcccugg agccucuggu ggaccugccu      780

aucggcauca auaucaccag auuccagacc cugcuggccc ugcacagauc auaucuuaca      840

ccaggcgauu cgucaagcgg uuggaccgcu ggagcugcgg cauauuacgu gggcuaccug      900

cagccuagaa ccuuccugcu gaaguacaau gagaauggua cgauaaccga cgcaguugau      960

ugugcccugg acccucugag cgagaccaag ugcacccuga agagcuucac cguggagaag     1020

ggcaucuacc agaccagcaa uuucagagug cagccuaccg agagcaucgu gagauucccu     1080

aauaucacca aucugugccc uuucgacgag guguucaaug ccaccagauu cgccagcgug     1140

uacgcaugga accgcaagcg gauaagcaau ugcguggccg acuacagcgu gcuguacaau     1200

cuggccccau ucuucaccuu caaauguuau gguguuucgc caacaaagcu gaaugaccug     1260

ugcuucacca auguguacgc cgacagcuuc gugaucagag gcgacgaggu gagacagauc     1320

gcgccagggc agaccggcaa caucgccgac uacaauuaca agcugccuga cgacuucacc     1380

ggcugcguga ucgcguggaa cucuaacaag cuggacucga aaguuucagg caauuacaau     1440

uaccuguaca gacuguucag aaagagcaau cugaagccuu ucgagagaga caucagcacc     1500

gagaucuacc aggccggcaa caagccgugu aauggcgugg cgggcuucaa uugcuacuuc     1560

ccucugcgca gcuacagcuu ccggccuacc uacggcgugg gccaccagcc uuacagagug     1620

guggugcuga gcuucgagcu gcugcacgcu cccgcuaccg ugugcggccc uaagaagagc     1680

accaaucugg ugaagaauaa gugcgugaau uucaauuuca auggucuaaa gggaacgggc     1740

gugcugaccg agagcaauaa gaaguuucuu cccuuucaac aauucggcag agacaucgcc     1800

gacaccacag augcuguaag agacccucag acccuggaga uccuggacau cacuccgugu     1860

agcuucggcg gcgugagcgu gaucacaccg ggcaccaaua ccagcaauca gguggccgug     1920

cuguaccagg gcgugaauug caccgaggug ccuguggcca uccacgccga ccagcugacu     1980

cccacuugga ggguauauuc cacgggaagc aauguguucc agaccagagc cggcugccug     2040

aucggcgccg aguacgugaa uaauagcuac gagugcgaca ucccuaucgg cgccggcauc     2100

ugcgccagcu accagaccca gaccaagagc cacggcggca gcggcagcgu ggccagccag     2160

agcaucaucg ccuacaccau gagccugggc gccgagaaua gcguggccua cagcaauaau     2220

agcaucgcca ucccuaccaa uuucaccauc agcgugacca ccgaaauauu accagucucc     2280

augaccaaga ccagcgugga cugcaccaug uacaucugcg gcgacagcac cgagugcagc     2340

aaucugcugc ugcaguacgg cagcuucugc acccagcuga agagagcccu gaccggcauc     2400

gccguggagc aggacaagaa uacccaggag guguucgccc aggugaagca gaucuacaag     2460

acuccgccga ucaaguacuu cggcggcuuc aauuucagcc aaauacuccc agauccaagc     2520

aagccuagcg ccaacagcuu caucgaggac cugcuguuca auaaggugac ccuggccgac     2580

gccggcuuca ucaagcagua cggcgacugc cuaggugaua uugcggcaag agaccugauc     2640

ugcgcccaga aguuuaaggg uuugacagua cuaccuccuc ugcugaccga cgagaugaua     2700

gcacaauaua cgucggcauu gcucgcuggc acgaucacau cgggcuggac uuucggcgcc     2760

ggagcagcgu ugcaaauccc uuucgccaug cagauggccu acagauucaa uggcaucggc     2820

gugacccaga augugcugua cgagaaucag aagcugaucg ccaaucaguu caauagcgcc     2880

aucggcaaga uccaggacag ccugagcagc accgccagcg cccugggcaa gcugcaggac     2940

guggugaauc acaaugccca ggcccugaau acccugguga agcagcugag cagcaaguuc     3000

ggcgccauca guaguguacu caacgacauc uucagcagac uggacccacc agaggccgag     3060

gugcaaauug aucgucuuau uacuggcaga cugcagagcc ugcagaccua cgugacccag     3120

cagcugauca gagccgccga gaucagagcc agcgccaauc uggccgccac caagaugagc     3180

gagugcgugc ugggccagag caagagagug gacuucugcg gcaagggcua ccaccugaug     3240

agcuucccuc agagcgcucc acauggcgug guguuccugc acgugaccua cgugccugcc     3300

caggagaaga auuucaccac cgcacccgca aucugccacg acggcaaggc ccacuucccu     3360

agagagggcg uguucgugag caauggcacc cacugguucg ugacccagag aaauuucuac     3420

gagccucaga ucaucaccac cgacaauacc uucgugagcg gcaauugcga cguggugauc     3480

gggauaguca auaauacugu cuacgacccu cugcagccug agcuggacag cuucaaggag     3540

gagcuggaca aguacuucaa gaaucacacc agcccugacg uggaccucgg ugauauuucg     3600

ggaaucaaug ccagcguggu gaauauccag aaggaaauug aucggcucaa cgaaguggcc     3660

aagaaucuga augagagccu gaucgaccug caggagcugg gcaaguacga gcaguacauc     3720

aaguggccuu gguacaucug gcugggcuuc aucgccggcc ugaucgccau cgugauggug     3780

accaucaugc ugugcugcau gaccuccugu uguuccuguu ugaaagggug uuguucgugu     3840

ggguccugcu gcaaguucga cgaggacgac agcgagccug ugcugaaggg cgugaagcug     3900

cacuacaccu aacucgagac uaguagccaa cacccugucu aaaaaacaua aauuucuuua     3960

aucauuuugc cucuuuucuc ugugcuucaa uuaauaaaaa auggaaagaa ccuaaaaaaa     4020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                   4127


<210>  28
<211>  6800
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA sequence of plasmid template of RBMRNA-Omicron vaccine

<400>  28
tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga gaaagcgcca       60

cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag      120

agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc      180

gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga      240

aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca      300

tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag      360

ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg      420

aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct      480

ggcacgacag gtttcccgac tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt      540

agctcactca ttaggcaccc caggctttac actttatgct tccggctcgt atgttgtgtg      600

gaattgtgag cggataacaa tttcacacag gaaacagcta tgaccatgat tacgccaagc      660

tctaatacga ctcactataa tgagacaagc ttgtcccgca gtcggcgtcc agcggctctg      720

cttgttcgtg tgtgtgtcgt tgcaggcctt attcagatct accggtggta ccgccaccat      780

gttcgtgttc ctggtgctgc tgcctctggt gagcagccag tgcgtgaatc tgaccaccag      840

aacccagctg cctcctgcct acaccaatag cttcaccaga ggagtttatt atcccgataa      900

ggtgttcaga agtagtgtat tacatagtac ccaggacctg ttcctacctt tcttcagtaa      960

cgtgacctgg ttccacgtca tcagcggcac caatggcacc aagagattcg acaatcctgt     1020

gctgcctttc aatgacggcg tgtacttcgc cagcatcgag aagagcaata tcatcagagg     1080

ctggatcttc ggcaccacct tggattccaa gactcagagc ctgctgattg taaacaacgc     1140

tacaaatgtg gtgatcaagg tgtgcgagtt ccagttctgc aatgaccctt tcctggacca     1200

taagaacaac aagagctgga tggagagcga gttccgcgta tattcgtcgg ctaataattg     1260

caccttcgag tacgtgagcc agcctttcct gatggacctg gagggcaagc agggcaattt     1320

caagaatctg agagagttcg tgttcaagaa tatcgacggc tacttcaaga tctacagcaa     1380

gcacacaccc attatcgtga gagagccgga ggacctgcct cagggcttca gcgccctgga     1440

gcctctggtg gacctgccta tcggcatcaa tatcaccaga ttccagaccc tgctggccct     1500

gcacagatca tatcttacac caggcgattc gtcaagcggt tggaccgctg gagctgcggc     1560

atattacgtg ggctacctgc agcctagaac cttcctgctg aagtacaatg agaatggtac     1620

gataaccgac gcagttgatt gtgccctgga ccctctgagc gagaccaagt gcaccctgaa     1680

gagcttcacc gtggagaagg gcatctacca gaccagcaat ttcagagtgc agcctaccga     1740

gagcatcgtg agattcccta atatcaccaa tctgtgccct ttcgacgagg tgttcaatgc     1800

caccagattc gccagcgtgt acgcatggaa ccgcaagcgg ataagcaatt gcgtggccga     1860

ctacagcgtg ctgtacaatc tggccccatt cttcaccttc aaatgttatg gtgtttcgcc     1920

aacaaagctg aatgacctgt gcttcaccaa tgtgtacgcc gacagcttcg tgatcagagg     1980

cgacgaggtg agacagatcg cgccagggca gaccggcaac atcgccgact acaattacaa     2040

gctgcctgac gacttcaccg gctgcgtgat cgcgtggaac tctaacaagc tggactcgaa     2100

agtttcaggc aattacaatt acctgtacag actgttcaga aagagcaatc tgaagccttt     2160

cgagagagac atcagcaccg agatctacca ggccggcaac aagccgtgta atggcgtggc     2220

gggcttcaat tgctacttcc ctctgcgcag ctacagcttc cggcctacct acggcgtggg     2280

ccaccagcct tacagagtgg tggtgctgag cttcgagctg ctgcacgctc ccgctaccgt     2340

gtgcggccct aagaagagca ccaatctggt gaagaataag tgcgtgaatt tcaatttcaa     2400

tggtctaaag ggaacgggcg tgctgaccga gagcaataag aagtttcttc cctttcaaca     2460

attcggcaga gacatcgccg acaccacaga tgctgtaaga gaccctcaga ccctggagat     2520

cctggacatc actccgtgta gcttcggcgg cgtgagcgtg atcacaccgg gcaccaatac     2580

cagcaatcag gtggccgtgc tgtaccaggg cgtgaattgc accgaggtgc ctgtggccat     2640

ccacgccgac cagctgactc ccacttggag ggtatattcc acgggaagca atgtgttcca     2700

gaccagagcc ggctgcctga tcggcgccga gtacgtgaat aatagctacg agtgcgacat     2760

ccctatcggc gccggcatct gcgccagcta ccagacccag accaagagcc acggcggcag     2820

cggcagcgtg gccagccaga gcatcatcgc ctacaccatg agcctgggcg ccgagaatag     2880

cgtggcctac agcaataata gcatcgccat ccctaccaat ttcaccatca gcgtgaccac     2940

cgaaatatta ccagtctcca tgaccaagac cagcgtggac tgcaccatgt acatctgcgg     3000

cgacagcacc gagtgcagca atctgctgct gcagtacggc agcttctgca cccagctgaa     3060

gagagccctg accggcatcg ccgtggagca ggacaagaat acccaggagg tgttcgccca     3120

ggtgaagcag atctacaaga ctccgccgat caagtacttc ggcggcttca atttcagcca     3180

aatactccca gatccaagca agcctagcgc caacagcttc atcgaggacc tgctgttcaa     3240

taaggtgacc ctggccgacg ccggcttcat caagcagtac ggcgactgcc taggtgatat     3300

tgcggcaaga gacctgatct gcgcccagaa gtttaagggt ttgacagtac tacctcctct     3360

gctgaccgac gagatgatag cacaatatac gtcggcattg ctcgctggca cgatcacatc     3420

gggctggact ttcggcgccg gagcagcgtt gcaaatccct ttcgccatgc agatggccta     3480

cagattcaat ggcatcggcg tgacccagaa tgtgctgtac gagaatcaga agctgatcgc     3540

caatcagttc aatagcgcca tcggcaagat ccaggacagc ctgagcagca ccgccagcgc     3600

cctgggcaag ctgcaggacg tggtgaatca caatgcccag gccctgaata ccctggtgaa     3660

gcagctgagc agcaagttcg gcgccatcag tagtgtactc aacgacatct tcagcagact     3720

ggacccacca gaggccgagg tgcaaattga tcgtcttatt actggcagac tgcagagcct     3780

gcagacctac gtgacccagc agctgatcag agccgccgag atcagagcca gcgccaatct     3840

ggccgccacc aagatgagcg agtgcgtgct gggccagagc aagagagtgg acttctgcgg     3900

caagggctac cacctgatga gcttccctca gagcgctcca catggcgtgg tgttcctgca     3960

cgtgacctac gtgcctgccc aggagaagaa tttcaccacc gcacccgcaa tctgccacga     4020

cggcaaggcc cacttcccta gagagggcgt gttcgtgagc aatggcaccc actggttcgt     4080

gacccagaga aatttctacg agcctcagat catcaccacc gacaatacct tcgtgagcgg     4140

caattgcgac gtggtgatcg ggatagtcaa taatactgtc tacgaccctc tgcagcctga     4200

gctggacagc ttcaaggagg agctggacaa gtacttcaag aatcacacca gccctgacgt     4260

ggacctcggt gatatttcgg gaatcaatgc cagcgtggtg aatatccaga aggaaattga     4320

tcggctcaac gaagtggcca agaatctgaa tgagagcctg atcgacctgc aggagctggg     4380

caagtacgag cagtacatca agtggccttg gtacatctgg ctgggcttca tcgccggcct     4440

gatcgccatc gtgatggtga ccatcatgct gtgctgcatg acctcctgtt gttcctgttt     4500

gaaagggtgt tgttcgtgtg ggtcctgctg caagttcgac gaggacgaca gcgagcctgt     4560

gctgaagggc gtgaagctgc actacaccta actcgagact agtagccaac accctgtcta     4620

aaaaacataa atttctttaa tcattttgcc tcttttctct gtgcttcaat taataaaaaa     4680

tggaaagaac ctaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4740

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4800

aaaaaaggat cctctagact gcaggagctc gatatcgaat tcgtattcta tagtgtcacc     4860

taaatccaat tcactggccg tcgttttaca acgtcgtgac tgggaaaacc ctggcgttac     4920

ccaacttaat cgccttgcag cacatccccc tttcgccagc tggcgtaata gcgaagaggc     4980

ccgcaccgat cgcccttccc aacagttgcg cagcctgaat ggcgaatggc gcctgatgcg     5040

gtattttctc cttacgcatc tgtgcggtat ttcacaccgc atatggggca ctctcagtac     5100

aatctgctct gatgccgcat agttaagcca gccccgacac ccgccaacac ccgctgacgc     5160

gccctgacgg gcttgtctgc tcccggcatc cgcttacaga caagctgtga ccgtctccgg     5220

gagctgcatg tgtcagaggt tttcaccgtc atcaccgaaa cgcgcgagac gaaagggcct     5280

cgtgatacgc ctatttttat aggttaatgt catgataata atggtttctt agacgtcagg     5340

tggcactttt cggggaaatg tgcgcggaac ccctatttgt ttatttttct aaatacattc     5400

aaatatgtat ccgctcatga gacaataacc ctgataaatg cttcaataat attgaaaaag     5460

gaagagtatg agccatattc aacgggaaac gtcttgctct aggccgcgat taaattccaa     5520

catggatgct gatttatatg ggtataaatg ggctcgcgat aatgtcgggc aatcaggtgc     5580

gacaatctat cgattgtatg ggaagcccga tgcgccagag ttgtttctga aacatggcaa     5640

aggtagcgtt gccaatgatg ttacagatga gatggtcaga ctaaactggc tgacggaatt     5700

tatgcctctt ccgaccatca agcattttat ccgtactcct gatgatgcat ggttactcac     5760

cactgcgatc cccgggaaaa cagcattcca ggtattagaa gaatatcctg attcaggtga     5820

aaatattgtt gatgcgctgg cagtgttcct gcgccggttg cattcgattc ctgtttgtaa     5880

ttgtcctttt aacagcgatc gcgtatttcg tctcgctcag gcgcaatcac gaatgaataa     5940

cggtttggtt gatgcgagtg attttgatga cgagcgtaat ggctggcctg ttgaacaagt     6000

ctggaaagaa atgcataaac ttttgccatt ctcaccggat tcagtcgtca ctcatggtga     6060

tttctcactt gataacctta tttttgacga ggggaaatta ataggttgta ttgatgttgg     6120

acgagtcgga atcgcagacc gataccagga tcttgccatc ctatggaact gcctcggtga     6180

gttttctcct tcattacaga aacggctttt tcaaaaatat ggtattgata atcctgatat     6240

gaataaattg cagtttcatt tgatgctcga tgagtttttc taactgtcag accaagttta     6300

ctcatatata ctttagattg atttaaaact tcatttttaa tttaaaagga tctaggtgaa     6360

gatccttttt gataatctca tgaccaaaat cccttaacgt gagttttcgt tccactgagc     6420

gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat     6480

ctgctgcttg caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga     6540

gctaccaact ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt     6600

tcttctagtg tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata     6660

cctcgctctg ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac     6720

cgggttggac tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg     6780

ttcgtgcaca cagcccagct                                                 6800


<210>  29
<211>  1273
<212>  PRT
<213>  Unknown

<220>
<223>  Amino acid sequence of SARS-CoV-2 wild type S protein

<400>  29

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  30
<211>  1250
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of recombinant S protein

<400>  30

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro 
            20                  25                  30          


Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val 
        35                  40                  45              


Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe 
    50                  55                  60                  


Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn 
65                  70                  75                  80  


Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val 
                85                  90                  95      


Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe 
            100                 105                 110         


Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn 
        115                 120                 125             


Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp 
    130                 135                 140                 


Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu 
145                 150                 155                 160 


Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr 
                165                 170                 175     


Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe 
            180                 185                 190         


Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys 
        195                 200                 205             


Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln 
    210                 215                 220                 


Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn 
225                 230                 235                 240 


Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr 
                245                 250                 255     


Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr 
            260                 265                 270         


Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn 
        275                 280                 285             


Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu 
    290                 295                 300                 


Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln 
305                 310                 315                 320 


Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro 
                325                 330                 335     


Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
            340                 345                 350         


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
        355                 360                 365             


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
    370                 375                 380                 


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
385                 390                 395                 400 


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
                405                 410                 415     


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
            420                 425                 430         


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
        435                 440                 445             


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
    450                 455                 460                 


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
465                 470                 475                 480 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
                485                 490                 495     


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
            500                 505                 510         


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
        515                 520                 525             


Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys 
    530                 535                 540                 


Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu 
545                 550                 555                 560 


Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala 
                565                 570                 575     


Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp 
            580                 585                 590         


Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr 
        595                 600                 605             


Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr 
    610                 615                 620                 


Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg 
625                 630                 635                 640 


Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu 
                645                 650                 655     


Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile 
            660                 665                 670         


Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly 
        675                 680                 685             


Gly Ser Gly Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser 
    690                 695                 700                 


Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile 
705                 710                 715                 720 


Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser 
                725                 730                 735     


Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser 
            740                 745                 750         


Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln 
        755                 760                 765             


Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr 
    770                 775                 780                 


Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile 
785                 790                 795                 800 


Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser 
                805                 810                 815     


Lys Pro Ser Ala Asn Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val 
            820                 825                 830         


Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly 
        835                 840                 845             


Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu 
    850                 855                 860                 


Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr 
865                 870                 875                 880 


Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala 
                885                 890                 895     


Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe 
            900                 905                 910         


Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu 
        915                 920                 925             


Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu 
    930                 935                 940                 


Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln 
945                 950                 955                 960 


Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe 
                965                 970                 975     


Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro 
            980                 985                 990         


Pro Glu Ala Glu Val Gln Ile Asp  Arg Leu Ile Thr Gly  Arg Leu Gln 
        995                 1000                 1005             


Ser Leu  Gln Thr Tyr Val Thr  Gln Gln Leu Ile Arg  Ala Ala Glu 
    1010                 1015                 1020             


Ile Arg  Ala Ser Ala Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys 
    1025                 1030                 1035             


Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr 
    1040                 1045                 1050             


His Leu  Met Ser Phe Pro Gln  Ser Ala Pro His Gly  Val Val Phe 
    1055                 1060                 1065             


Leu His  Val Thr Tyr Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr 
    1070                 1075                 1080             


Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala His Phe  Pro Arg Glu 
    1085                 1090                 1095             


Gly Val  Phe Val Ser Asn Gly  Thr His Trp Phe Val  Thr Gln Arg 
    1100                 1105                 1110             


Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val 
    1115                 1120                 1125             


Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile Val Asn  Asn Thr Val 
    1130                 1135                 1140             


Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu 
    1145                 1150                 1155             


Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro Asp Val  Asp Leu Gly 
    1160                 1165                 1170             


Asp Ile  Ser Gly Ile Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu 
    1175                 1180                 1185             


Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu 
    1190                 1195                 1200             


Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu Gln Tyr  Ile Lys Trp 
    1205                 1210                 1215             


Pro Ser  Ala Ile Gly Gly Tyr  Ile Pro Glu Ala Pro  Arg Asp Gly 
    1220                 1225                 1230             


Gln Ala  Tyr Val Arg Lys Asp  Gly Glu Trp Val Leu  Leu Ser Thr 
    1235                 1240                 1245             


Phe Leu  
    1250 


<210>  31
<211>  1231
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of recombinant S protein

<400>  31

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro 
            20                  25                  30          


Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val 
        35                  40                  45              


Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe 
    50                  55                  60                  


Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn 
65                  70                  75                  80  


Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val 
                85                  90                  95      


Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe 
            100                 105                 110         


Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn 
        115                 120                 125             


Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp 
    130                 135                 140                 


Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu 
145                 150                 155                 160 


Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr 
                165                 170                 175     


Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe 
            180                 185                 190         


Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys 
        195                 200                 205             


Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln 
    210                 215                 220                 


Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn 
225                 230                 235                 240 


Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr 
                245                 250                 255     


Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr 
            260                 265                 270         


Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn 
        275                 280                 285             


Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu 
    290                 295                 300                 


Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln 
305                 310                 315                 320 


Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro 
                325                 330                 335     


Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
            340                 345                 350         


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
        355                 360                 365             


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
    370                 375                 380                 


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
385                 390                 395                 400 


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
                405                 410                 415     


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
            420                 425                 430         


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
        435                 440                 445             


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
    450                 455                 460                 


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
465                 470                 475                 480 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
                485                 490                 495     


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
            500                 505                 510         


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
        515                 520                 525             


Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys 
    530                 535                 540                 


Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu 
545                 550                 555                 560 


Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala 
                565                 570                 575     


Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp 
            580                 585                 590         


Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr 
        595                 600                 605             


Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr 
    610                 615                 620                 


Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg 
625                 630                 635                 640 


Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu 
                645                 650                 655     


Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile 
            660                 665                 670         


Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly 
        675                 680                 685             


Gly Ser Gly Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser 
    690                 695                 700                 


Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile 
705                 710                 715                 720 


Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser 
                725                 730                 735     


Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser 
            740                 745                 750         


Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln 
        755                 760                 765             


Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr 
    770                 775                 780                 


Gln Glu Val Phe Ala Gln Val Lys Gln Pro Asp Pro Ser Lys Pro Ser 
785                 790                 795                 800 


Ala Asn Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala 
                805                 810                 815     


Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala 
            820                 825                 830         


Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu 
        835                 840                 845             


Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu 
    850                 855                 860                 


Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala 
865                 870                 875                 880 


Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile 
                885                 890                 895     


Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn 
            900                 905                 910         


Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr 
        915                 920                 925             


Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln 
    930                 935                 940                 


Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile 
945                 950                 955                 960 


Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala 
                965                 970                 975     


Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln 
            980                 985                 990         


Thr Tyr Val Thr Gln Gln Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser 
        995                 1000                 1005             


Ala Asn  Leu Ala Ala Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln 
    1010                 1015                 1020             


Ser Lys  Arg Val Asp Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser 
    1025                 1030                 1035             


Phe Pro  Gln Ser Ala Pro His  Gly Val Val Phe Leu  His Val Thr 
    1040                 1045                 1050             


Tyr Val  Pro Ala Gln Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile 
    1055                 1060                 1065             


Cys His  Asp Gly Lys Ala His  Phe Pro Arg Glu Gly  Val Phe Val 
    1070                 1075                 1080             


Ser Asn  Gly Thr His Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu 
    1085                 1090                 1095             


Pro Gln  Ile Ile Thr Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys 
    1100                 1105                 1110             


Asp Val  Val Ile Gly Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu 
    1115                 1120                 1125             


Gln Pro  Glu Leu Asp Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe 
    1130                 1135                 1140             


Lys Asn  His Thr Ser Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly 
    1145                 1150                 1155             


Ile Asn  Ala Ser Val Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu 
    1160                 1165                 1170             


Asn Glu  Val Ala Lys Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln 
    1175                 1180                 1185             


Glu Leu  Gly Lys Tyr Glu Gln  Tyr Ile Lys Trp Pro  Ser Ala Ile 
    1190                 1195                 1200             


Gly Gly  Tyr Ile Pro Glu Ala  Pro Arg Asp Gly Gln  Ala Tyr Val 
    1205                 1210                 1215             


Arg Lys  Asp Gly Glu Trp Val  Leu Leu Ser Thr Phe  Leu 
    1220                 1225                 1230     


<210>  32
<211>  1274
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of recombinant S protein

<400>  32

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro 
            20                  25                  30          


Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val 
        35                  40                  45              


Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe 
    50                  55                  60                  


Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn 
65                  70                  75                  80  


Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val 
                85                  90                  95      


Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe 
            100                 105                 110         


Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn 
        115                 120                 125             


Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp 
    130                 135                 140                 


Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu 
145                 150                 155                 160 


Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr 
                165                 170                 175     


Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe 
            180                 185                 190         


Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys 
        195                 200                 205             


Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln 
    210                 215                 220                 


Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn 
225                 230                 235                 240 


Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr 
                245                 250                 255     


Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr 
            260                 265                 270         


Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn 
        275                 280                 285             


Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu 
    290                 295                 300                 


Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln 
305                 310                 315                 320 


Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro 
                325                 330                 335     


Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
            340                 345                 350         


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
        355                 360                 365             


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
    370                 375                 380                 


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
385                 390                 395                 400 


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
                405                 410                 415     


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
            420                 425                 430         


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
        435                 440                 445             


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
    450                 455                 460                 


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
465                 470                 475                 480 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
                485                 490                 495     


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
            500                 505                 510         


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
        515                 520                 525             


Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys 
    530                 535                 540                 


Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu 
545                 550                 555                 560 


Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala 
                565                 570                 575     


Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp 
            580                 585                 590         


Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr 
        595                 600                 605             


Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr 
    610                 615                 620                 


Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg 
625                 630                 635                 640 


Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu 
                645                 650                 655     


Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile 
            660                 665                 670         


Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly 
        675                 680                 685             


Gly Ser Gly Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser 
    690                 695                 700                 


Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile 
705                 710                 715                 720 


Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser 
                725                 730                 735     


Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser 
            740                 745                 750         


Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln 
        755                 760                 765             


Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr 
    770                 775                 780                 


Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile 
785                 790                 795                 800 


Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser 
                805                 810                 815     


Lys Pro Ser Ala Asn Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val 
            820                 825                 830         


Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly 
        835                 840                 845             


Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu 
    850                 855                 860                 


Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr 
865                 870                 875                 880 


Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala 
                885                 890                 895     


Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe 
            900                 905                 910         


Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu 
        915                 920                 925             


Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu 
    930                 935                 940                 


Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln 
945                 950                 955                 960 


Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe 
                965                 970                 975     


Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro 
            980                 985                 990         


Pro Glu Ala Glu Val Gln Ile Asp  Arg Leu Ile Thr Gly  Arg Leu Gln 
        995                 1000                 1005             


Ser Leu  Gln Thr Tyr Val Thr  Gln Gln Leu Ile Arg  Ala Ala Glu 
    1010                 1015                 1020             


Ile Arg  Ala Ser Ala Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys 
    1025                 1030                 1035             


Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr 
    1040                 1045                 1050             


His Leu  Met Ser Phe Pro Gln  Ser Ala Pro His Gly  Val Val Phe 
    1055                 1060                 1065             


Leu His  Val Thr Tyr Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr 
    1070                 1075                 1080             


Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala His Phe  Pro Arg Glu 
    1085                 1090                 1095             


Gly Val  Phe Val Ser Asn Gly  Thr His Trp Phe Val  Thr Gln Arg 
    1100                 1105                 1110             


Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val 
    1115                 1120                 1125             


Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile Val Asn  Asn Thr Val 
    1130                 1135                 1140             


Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu 
    1145                 1150                 1155             


Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro Asp Val  Asp Leu Gly 
    1160                 1165                 1170             


Asp Ile  Ser Gly Ile Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu 
    1175                 1180                 1185             


Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu 
    1190                 1195                 1200             


Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu Gln Tyr  Ile Lys Trp 
    1205                 1210                 1215             


Pro Trp  Tyr Ile Trp Leu Gly  Phe Ile Ala Gly Leu  Ile Ala Ile 
    1220                 1225                 1230             


Val Met  Val Thr Ile Met Leu  Cys Cys Met Ser Ala  Ile Gly Gly 
    1235                 1240                 1245             


Tyr Ile  Pro Glu Ala Pro Arg  Asp Gly Gln Ala Tyr  Val Arg Lys 
    1250                 1255                 1260             


Asp Gly  Glu Trp Val Leu Leu  Ser Thr Phe Leu 
    1265                 1270                 


<210>  33
<211>  1255
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of recombinant S protein

<400>  33

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro 
            20                  25                  30          


Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val 
        35                  40                  45              


Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe 
    50                  55                  60                  


Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn 
65                  70                  75                  80  


Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val 
                85                  90                  95      


Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe 
            100                 105                 110         


Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn 
        115                 120                 125             


Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp 
    130                 135                 140                 


Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu 
145                 150                 155                 160 


Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr 
                165                 170                 175     


Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe 
            180                 185                 190         


Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys 
        195                 200                 205             


Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln 
    210                 215                 220                 


Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn 
225                 230                 235                 240 


Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr 
                245                 250                 255     


Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr 
            260                 265                 270         


Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn 
        275                 280                 285             


Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu 
    290                 295                 300                 


Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln 
305                 310                 315                 320 


Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro 
                325                 330                 335     


Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
            340                 345                 350         


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
        355                 360                 365             


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
    370                 375                 380                 


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
385                 390                 395                 400 


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
                405                 410                 415     


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
            420                 425                 430         


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
        435                 440                 445             


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
    450                 455                 460                 


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
465                 470                 475                 480 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
                485                 490                 495     


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
            500                 505                 510         


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
        515                 520                 525             


Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys 
    530                 535                 540                 


Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu 
545                 550                 555                 560 


Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala 
                565                 570                 575     


Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp 
            580                 585                 590         


Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr 
        595                 600                 605             


Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr 
    610                 615                 620                 


Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg 
625                 630                 635                 640 


Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu 
                645                 650                 655     


Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile 
            660                 665                 670         


Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly 
        675                 680                 685             


Gly Ser Gly Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser 
    690                 695                 700                 


Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile 
705                 710                 715                 720 


Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser 
                725                 730                 735     


Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser 
            740                 745                 750         


Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln 
        755                 760                 765             


Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr 
    770                 775                 780                 


Gln Glu Val Phe Ala Gln Val Lys Gln Pro Asp Pro Ser Lys Pro Ser 
785                 790                 795                 800 


Ala Asn Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala 
                805                 810                 815     


Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala 
            820                 825                 830         


Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu 
        835                 840                 845             


Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu 
    850                 855                 860                 


Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala 
865                 870                 875                 880 


Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile 
                885                 890                 895     


Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn 
            900                 905                 910         


Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr 
        915                 920                 925             


Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln 
    930                 935                 940                 


Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile 
945                 950                 955                 960 


Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala 
                965                 970                 975     


Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln 
            980                 985                 990         


Thr Tyr Val Thr Gln Gln Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser 
        995                 1000                 1005             


Ala Asn  Leu Ala Ala Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln 
    1010                 1015                 1020             


Ser Lys  Arg Val Asp Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser 
    1025                 1030                 1035             


Phe Pro  Gln Ser Ala Pro His  Gly Val Val Phe Leu  His Val Thr 
    1040                 1045                 1050             


Tyr Val  Pro Ala Gln Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile 
    1055                 1060                 1065             


Cys His  Asp Gly Lys Ala His  Phe Pro Arg Glu Gly  Val Phe Val 
    1070                 1075                 1080             


Ser Asn  Gly Thr His Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu 
    1085                 1090                 1095             


Pro Gln  Ile Ile Thr Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys 
    1100                 1105                 1110             


Asp Val  Val Ile Gly Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu 
    1115                 1120                 1125             


Gln Pro  Glu Leu Asp Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe 
    1130                 1135                 1140             


Lys Asn  His Thr Ser Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly 
    1145                 1150                 1155             


Ile Asn  Ala Ser Val Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu 
    1160                 1165                 1170             


Asn Glu  Val Ala Lys Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln 
    1175                 1180                 1185             


Glu Leu  Gly Lys Tyr Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile 
    1190                 1195                 1200             


Trp Leu  Gly Phe Ile Ala Gly  Leu Ile Ala Ile Val  Met Val Thr 
    1205                 1210                 1215             


Ile Met  Leu Cys Cys Met Ser  Ala Ile Gly Gly Tyr  Ile Pro Glu 
    1220                 1225                 1230             


Ala Pro  Arg Asp Gly Gln Ala  Tyr Val Arg Lys Asp  Gly Glu Trp 
    1235                 1240                 1245             


Val Leu  Leu Ser Thr Phe Leu  
    1250                 1255 


<210>  34
<211>  4085
<212>  RNA
<213>  Artificial sequence

<220>
<223>  mRNA sequence of recombinant S protein

<400>  34
aggagacaag cuugucccgc agucggcguc cagcggcucu gcuuguucgu gugugugucg       60

uugcaggccu uauucagauc uaccgguggu accgccacca uggacuggau cuggagaauc      120

cuguuccugg ugggggcugc cacuggcgcc cauagccagu gcgugaaucu gaccaccaga      180

acccagcugc cuccugccua caccaauagc uucaccagag gaguuuauua ucccgauaag      240

guguucagaa guaguguauu acauaguacc caggaccugu uccuaccuuu cuucaguaac      300

gugaccuggu uccacgccau ccacgugagc ggcaccaaug gcaccaagag auucgacaau      360

ccugugcugc cuuucaauga cggcguguac uucgccagca ccgagaagag caauaucauc      420

agaggcugga ucuucggcac caccuuggau uccaagacuc agagccugcu gauuguaaac      480

aacgcuacaa auguggugau caaggugugc gaguuccagu ucugcaauga cccuuuccug      540

gguguuuauu aucauaagaa caacaagagc uggauggaga gcgaguuccg cguauauucg      600

ucggcuaaua auugcaccuu cgaguacgug agccagccuu uccugaugga ccuggagggc      660

aagcagggca auuucaagaa ucugagagag uucguguuca agaauaucga cggcuacuuc      720

aagaucuaca gcaagcacac acccauuaau cuggugagag accugccuca gggcuucagc      780

gcccuggagc cucuggugga ccugccuauc ggcaucaaua ucaccagauu ccagacccug      840

cuggcccugc acagaucaua ucuuacacca ggcgauucgu caagcgguug gaccgcugga      900

gcugcggcau auuacguggg cuaccugcag ccuagaaccu uccugcugaa guacaaugag      960

aaugguacga uaaccgacgc aguugauugu gcccuggacc cucugagcga gaccaagugc     1020

acccugaaga gcuucaccgu ggagaagggc aucuaccaga ccagcaauuu cagagugcag     1080

ccuaccgaga gcaucgugag auucccuaau aucaccaauc ugugcccuuu cggcgaggug     1140

uucaaugcca ccagauucgc cagcguguac gcauggaacc gcaagcggau aagcaauugc     1200

guggccgacu acagcgugcu guacaauagc gccagcuuca gcaccuucaa auguuauggu     1260

guuucgccaa caaagcugaa ugaccugugc uucaccaaug uguacgccga cagcuucgug     1320

aucagaggcg acgaggugag acagaucgcg ccagggcaga ccggcaagau cgccgacuac     1380

aauuacaagc ugccugacga cuucaccggc ugcgugaucg cguggaacuc uaacaaccug     1440

gacucgaaag uuggaggcaa uuacaauuac cuguacagac uguucagaaa gagcaaucug     1500

aagccuuucg agagagacau cagcaccgag aucuaccagg ccggcagcac accguguaau     1560

ggcguggagg gcuucaauug cuacuucccu cugcagagcu acggcuucca gccuaccaau     1620

ggcgugggcu accagccuua cagaguggug gugcugagcu ucgagcugcu gcacgcuccc     1680

gcuaccgugu gcggcccuaa gaagagcacc aaucugguga agaauaagug cgugaauuuc     1740

aauuucaaug gucuaacugg aacgggcgug cugaccgaga gcaauaagaa guuucuuccc     1800

uuucaacaau ucggcagaga caucgccgac accacagaug cuguaagaga cccucagacc     1860

cuggagaucc uggacaucac uccguguagc uucggcggcg ugagcgugau cacaccgggc     1920

accaauacca gcaaucaggu ggccgugcug uaccaggacg ugaauugcac cgaggugccu     1980

guggccaucc acgccgacca gcugacuccc acuuggaggg uauauuccac gggaagcaau     2040

guguuccaga ccagagccgg cugccugauc ggcgccgagc acgugaauaa uagcuacgag     2100

ugcgacaucc cuaucggcgc cggcaucugc gccagcuacc agacccagac caauagcccu     2160

ggcggcagcg gcagcguggc cagccagagc aucaucgccu acaccaugag ccugggcgcc     2220

gagaauagcg uggccuacag caauaauagc aucgccaucc cuaccaauuu caccaucagc     2280

gugaccaccg aaauauuacc agucuccaug accaagacca gcguggacug caccauguac     2340

aucugcggcg acagcaccga gugcagcaau cugcugcugc aguacggcag cuucugcacc     2400

cagcugaaua gagcccugac cggcaucgcc guggagcagg acaagaauac ccaggaggug     2460

uucgcccagg ugaagcagau cuacaagacu ccgccgauca aggacuucgg cggcuucaau     2520

uucagccaaa uacucccaga uccaagcaag ccuagcgcca acagcuucau cgaggaccug     2580

cuguucaaua aggugacccu ggccgacgcc ggcuucauca agcaguacgg cgacugccua     2640

ggugauauug cggcaagaga ccugaucugc gcccagaagu uuaacgguuu gacaguacua     2700

ccuccucugc ugaccgacga gaugauagca caauauacgu cggcauugcu cgcuggcacg     2760

aucacaucgg gcuggacuuu cggcgccgga gcagcguugc aaaucccuuu cgccaugcag     2820

auggccuaca gauucaaugg caucggcgug acccagaaug ugcuguacga gaaucagaag     2880

cugaucgcca aucaguucaa uagcgccauc ggcaagaucc aggacagccu gagcagcacc     2940

gccagcgccc ugggcaagcu gcaggacgug gugaaucaga augcccaggc ccugaauacc     3000

cuggugaagc agcugagcag caauuucggc gccaucagua guguacucaa cgacauccug     3060

agcagacugg acccgccgga ggccgaggug caaauugauc gucuuauuac uggcagacug     3120

cagagccugc agaccuacgu gacccagcag cugaucagag ccgccgagau cagagccagc     3180

gccaaucugg ccgccaccaa gaugagcgag ugcgugcugg gccagagcaa gagaguggac     3240

uucugcggca agggcuacca ccugaugagc uucccucaga gcgcuccaca uggcguggug     3300

uuccugcacg ugaccuacgu gccugcccag gagaagaauu ucaccaccgc acccgcaauc     3360

ugccacgacg gcaaggccca cuucccuaga gagggcgugu ucgugagcaa uggcacccac     3420

ugguucguga cccagagaaa uuucuacgag ccucagauca ucaccaccga caauaccuuc     3480

gugagcggca auugcgacgu ggugaucggg auagucaaua auacugucua cgacccucug     3540

cagccugagc uggacagcuu caaggaggag cuggacaagu acuucaagaa ucacaccagc     3600

ccugacgugg accucgguga uauuucggga aucaaugcca gcguggugaa uauccagaag     3660

gaaauugauc ggcucaacga aguggccaag aaucugaaug agagccugau cgaccugcag     3720

gagcugggca aguacgagca guacaucaag uggccuagcg ccaucggcgg cuacaucccc     3780

gaggccccca gggacggcca ggccuacgug aggaaggacg gcgagugggu gcugcugagc     3840

accuuccugu gacucgagac uaguagccaa cacccugucu aaaaaacaua aauuucuuua     3900

aucauuuugc cucuuuucuc ugugcuucaa uuaauaaaaa auggaaagaa ccuggauccg     3960

ucgacaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4080

aaaaa                                                                 4085


<210>  35
<211>  3973
<212>  RNA
<213>  Artificial sequence

<220>
<223>  mRNA sequence of recombinant S protein

<400>  35
gucccgcagu cggcguccag cggcucugcu uguucgugug ugugucguug caggccuuau       60

ucgccaccau ggacuggauc uggagaaucc uguuccuggu gggggcugcc acuggcgccc      120

auagccagug cgugaaucug accaccagaa cccagcugcc uccugccuac accaauagcu      180

ucaccagagg aguuuauuau cccgauaagg uguucagaag uaguguauua cauaguaccc      240

aggaccuguu ccuaccuuuc uucaguaacg ugaccugguu ccacgccauc cacgugagcg      300

gcaccaaugg caccaagaga uucgacaauc cugugcugcc uuucaaugac ggcguguacu      360

ucgccagcac cgagaagagc aauaucauca gaggcuggau cuucggcacc accuuggauu      420

ccaagacuca gagccugcug auuguaaaca acgcuacaaa uguggugauc aaggugugcg      480

aguuccaguu cugcaaugac ccuuuccugg guguuuauua ucauaagaac aacaagagcu      540

ggauggagag cgaguuccgc guauauucgu cggcuaauaa uugcaccuuc gaguacguga      600

gccagccuuu ccugauggac cuggagggca agcagggcaa uuucaagaau cugagagagu      660

ucguguucaa gaauaucgac ggcuacuuca agaucuacag caagcacaca cccauuaauc      720

uggugagaga ccugccucag ggcuucagcg cccuggagcc ucugguggac cugccuaucg      780

gcaucaauau caccagauuc cagacccugc uggcccugca cagaucauau cuuacaccag      840

gcgauucguc aagcgguugg accgcuggag cugcggcaua uuacgugggc uaccugcagc      900

cuagaaccuu ccugcugaag uacaaugaga augguacgau aaccgacgca guugauugug      960

cccuggaccc ucugagcgag accaagugca cccugaagag cuucaccgug gagaagggca     1020

ucuaccagac cagcaauuuc agagugcagc cuaccgagag caucgugaga uucccuaaua     1080

ucaccaaucu gugcccuuuc ggcgaggugu ucaaugccac cagauucgcc agcguguacg     1140

cauggaaccg caagcggaua agcaauugcg uggccgacua cagcgugcug uacaauagcg     1200

ccagcuucag caccuucaaa uguuauggug uuucgccaac aaagcugaau gaccugugcu     1260

ucaccaaugu guacgccgac agcuucguga ucagaggcga cgaggugaga cagaucgcgc     1320

cagggcagac cggcaagauc gccgacuaca auuacaagcu gccugacgac uucaccggcu     1380

gcgugaucgc guggaacucu aacaaccugg acucgaaagu uggaggcaau uacaauuacc     1440

uguacagacu guucagaaag agcaaucuga agccuuucga gagagacauc agcaccgaga     1500

ucuaccaggc cggcagcaca ccguguaaug gcguggaggg cuucaauugc uacuucccuc     1560

ugcagagcua cggcuuccag ccuaccaaug gcgugggcua ccagccuuac agaguggugg     1620

ugcugagcuu cgagcugcug cacgcucccg cuaccgugug cggcccuaag aagagcacca     1680

aucuggugaa gaauaagugc gugaauuuca auuucaaugg ucuaacugga acgggcgugc     1740

ugaccgagag caauaagaag uuucuucccu uucaacaauu cggcagagac aucgccgaca     1800

ccacagaugc uguaagagac ccucagaccc uggagauccu ggacaucacu ccguguagcu     1860

ucggcggcgu gagcgugauc acaccgggca ccaauaccag caaucaggug gccgugcugu     1920

accaggacgu gaauugcacc gaggugccug uggccaucca cgccgaccag cugacuccca     1980

cuuggagggu auauuccacg ggaagcaaug uguuccagac cagagccggc ugccugaucg     2040

gcgccgagca cgugaauaau agcuacgagu gcgacauccc uaucggcgcc ggcaucugcg     2100

ccagcuacca gacccagacc aauagcccug gcggcagcgg cagcguggcc agccagagca     2160

ucaucgccua caccaugagc cugggcgccg agaauagcgu ggccuacagc aauaauagca     2220

ucgccauccc uaccaauuuc accaucagcg ugaccaccga aauauuacca gucuccauga     2280

ccaagaccag cguggacugc accauguaca ucugcggcga cagcaccgag ugcagcaauc     2340

ugcugcugca guacggcagc uucugcaccc agcugaauag agcccugacc ggcaucgccg     2400

uggagcagga caagaauacc caggaggugu ucgcccaggu gaagcagcca gauccaagca     2460

agccuagcgc caacagcuuc aucgaggacc ugcuguucaa uaaggugacc cuggccgacg     2520

ccggcuucau caagcaguac ggcgacugcc uaggugauau ugcggcaaga gaccugaucu     2580

gcgcccagaa guuuaacggu uugacaguac uaccuccucu gcugaccgac gagaugauag     2640

cacaauauac gucggcauug cucgcuggca cgaucacauc gggcuggacu uucggcgccg     2700

gagcagcguu gcaaaucccu uucgccaugc agauggccua cagauucaau ggcaucggcg     2760

ugacccagaa ugugcuguac gagaaucaga agcugaucgc caaucaguuc aauagcgcca     2820

ucggcaagau ccaggacagc cugagcagca ccgccagcgc ccugggcaag cugcaggacg     2880

uggugaauca gaaugcccag gcccugaaua cccuggugaa gcagcugagc agcaauuucg     2940

gcgccaucag uaguguacuc aacgacaucc ugagcagacu ggacccgccg gaggccgagg     3000

ugcaaauuga ucgucuuauu acuggcagac ugcagagccu gcagaccuac gugacccagc     3060

agcugaucag agccgccgag aucagagcca gcgccaaucu ggccgccacc aagaugagcg     3120

agugcgugcu gggccagagc aagagagugg acuucugcgg caagggcuac caccugauga     3180

gcuucccuca gagcgcucca cauggcgugg uguuccugca cgugaccuac gugccugccc     3240

aggagaagaa uuucaccacc gcacccgcaa ucugccacga cggcaaggcc cacuucccua     3300

gagagggcgu guucgugagc aauggcaccc acugguucgu gacccagaga aauuucuacg     3360

agccucagau caucaccacc gacaauaccu ucgugagcgg caauugcgac guggugaucg     3420

ggauagucaa uaauacuguc uacgacccuc ugcagccuga gcuggacagc uucaaggagg     3480

agcuggacaa guacuucaag aaucacacca gcccugacgu ggaccucggu gauauuucgg     3540

gaaucaaugc cagcguggug aauauccaga aggaaauuga ucggcucaac gaaguggcca     3600

agaaucugaa ugagagccug aucgaccugc aggagcuggg caaguacgag caguacauca     3660

aguggccuag cgccaucggc ggcuacaucc ccgaggcccc cagggacggc caggccuacg     3720

ugaggaagga cggcgagugg gugcugcuga gcaccuuccu gugaagccaa cacccugucu     3780

aaaaaacaua aauuucuuua aucauuuugc cucuuuucuc ugugcuucaa uuaauaaaaa     3840

auggaaagaa ccuaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3960

aaaaaaaaaa aaa                                                        3973


<210>  36
<211>  4157
<212>  RNA
<213>  Artificial sequence

<220>
<223>  mRNA sequence of recombinant S protein

<400>  36
aggagacaag cuugucccgc agucggcguc cagcggcucu gcuuguucgu gugugugucg       60

uugcaggccu uauucagauc uaccgguggu accgccacca uggacuggau cuggagaauc      120

cuguuccugg ugggggcugc cacuggcgcc cauagccagu gcgugaaucu gaccaccaga      180

acccagcugc cuccugccua caccaauagc uucaccagag gaguuuauua ucccgauaag      240

guguucagaa guaguguauu acauaguacc caggaccugu uccuaccuuu cuucaguaac      300

gugaccuggu uccacgccau ccacgugagc ggcaccaaug gcaccaagag auucgacaau      360

ccugugcugc cuuucaauga cggcguguac uucgccagca ccgagaagag caauaucauc      420

agaggcugga ucuucggcac caccuuggau uccaagacuc agagccugcu gauuguaaac      480

aacgcuacaa auguggugau caaggugugc gaguuccagu ucugcaauga cccuuuccug      540

gguguuuauu aucauaagaa caacaagagc uggauggaga gcgaguuccg cguauauucg      600

ucggcuaaua auugcaccuu cgaguacgug agccagccuu uccugaugga ccuggagggc      660

aagcagggca auuucaagaa ucugagagag uucguguuca agaauaucga cggcuacuuc      720

aagaucuaca gcaagcacac acccauuaau cuggugagag accugccuca gggcuucagc      780

gcccuggagc cucuggugga ccugccuauc ggcaucaaua ucaccagauu ccagacccug      840

cuggcccugc acagaucaua ucuuacacca ggcgauucgu caagcgguug gaccgcugga      900

gcugcggcau auuacguggg cuaccugcag ccuagaaccu uccugcugaa guacaaugag      960

aaugguacga uaaccgacgc aguugauugu gcccuggacc cucugagcga gaccaagugc     1020

acccugaaga gcuucaccgu ggagaagggc aucuaccaga ccagcaauuu cagagugcag     1080

ccuaccgaga gcaucgugag auucccuaau aucaccaauc ugugcccuuu cggcgaggug     1140

uucaaugcca ccagauucgc cagcguguac gcauggaacc gcaagcggau aagcaauugc     1200

guggccgacu acagcgugcu guacaauagc gccagcuuca gcaccuucaa auguuauggu     1260

guuucgccaa caaagcugaa ugaccugugc uucaccaaug uguacgccga cagcuucgug     1320

aucagaggcg acgaggugag acagaucgcg ccagggcaga ccggcaagau cgccgacuac     1380

aauuacaagc ugccugacga cuucaccggc ugcgugaucg cguggaacuc uaacaaccug     1440

gacucgaaag uuggaggcaa uuacaauuac cuguacagac uguucagaaa gagcaaucug     1500

aagccuuucg agagagacau cagcaccgag aucuaccagg ccggcagcac accguguaau     1560

ggcguggagg gcuucaauug cuacuucccu cugcagagcu acggcuucca gccuaccaau     1620

ggcgugggcu accagccuua cagaguggug gugcugagcu ucgagcugcu gcacgcuccc     1680

gcuaccgugu gcggcccuaa gaagagcacc aaucugguga agaauaagug cgugaauuuc     1740

aauuucaaug gucuaacugg aacgggcgug cugaccgaga gcaauaagaa guuucuuccc     1800

uuucaacaau ucggcagaga caucgccgac accacagaug cuguaagaga cccucagacc     1860

cuggagaucc uggacaucac uccguguagc uucggcggcg ugagcgugau cacaccgggc     1920

accaauacca gcaaucaggu ggccgugcug uaccaggacg ugaauugcac cgaggugccu     1980

guggccaucc acgccgacca gcugacuccc acuuggaggg uauauuccac gggaagcaau     2040

guguuccaga ccagagccgg cugccugauc ggcgccgagc acgugaauaa uagcuacgag     2100

ugcgacaucc cuaucggcgc cggcaucugc gccagcuacc agacccagac caauagcccu     2160

ggcggcagcg gcagcguggc cagccagagc aucaucgccu acaccaugag ccugggcgcc     2220

gagaauagcg uggccuacag caauaauagc aucgccaucc cuaccaauuu caccaucagc     2280

gugaccaccg aaauauuacc agucuccaug accaagacca gcguggacug caccauguac     2340

aucugcggcg acagcaccga gugcagcaau cugcugcugc aguacggcag cuucugcacc     2400

cagcugaaua gagcccugac cggcaucgcc guggagcagg acaagaauac ccaggaggug     2460

uucgcccagg ugaagcagau cuacaagacu ccgccgauca aggacuucgg cggcuucaau     2520

uucagccaaa uacucccaga uccaagcaag ccuagcgcca acagcuucau cgaggaccug     2580

cuguucaaua aggugacccu ggccgacgcc ggcuucauca agcaguacgg cgacugccua     2640

ggugauauug cggcaagaga ccugaucugc gcccagaagu uuaacgguuu gacaguacua     2700

ccuccucugc ugaccgacga gaugauagca caauauacgu cggcauugcu cgcuggcacg     2760

aucacaucgg gcuggacuuu cggcgccgga gcagcguugc aaaucccuuu cgccaugcag     2820

auggccuaca gauucaaugg caucggcgug acccagaaug ugcuguacga gaaucagaag     2880

cugaucgcca aucaguucaa uagcgccauc ggcaagaucc aggacagccu gagcagcacc     2940

gccagcgccc ugggcaagcu gcaggacgug gugaaucaga augcccaggc ccugaauacc     3000

cuggugaagc agcugagcag caauuucggc gccaucagua guguacucaa cgacauccug     3060

agcagacugg acccgccgga ggccgaggug caaauugauc gucuuauuac uggcagacug     3120

cagagccugc agaccuacgu gacccagcag cugaucagag ccgccgagau cagagccagc     3180

gccaaucugg ccgccaccaa gaugagcgag ugcgugcugg gccagagcaa gagaguggac     3240

uucugcggca agggcuacca ccugaugagc uucccucaga gcgcuccaca uggcguggug     3300

uuccugcacg ugaccuacgu gccugcccag gagaagaauu ucaccaccgc acccgcaauc     3360

ugccacgacg gcaaggccca cuucccuaga gagggcgugu ucgugagcaa uggcacccac     3420

ugguucguga cccagagaaa uuucuacgag ccucagauca ucaccaccga caauaccuuc     3480

gugagcggca auugcgacgu ggugaucggg auagucaaua auacugucua cgacccucug     3540

cagccugagc uggacagcuu caaggaggag cuggacaagu acuucaagaa ucacaccagc     3600

ccugacgugg accucgguga uauuucggga aucaaugcca gcguggugaa uauccagaag     3660

gaaauugauc ggcucaacga aguggccaag aaucugaaug agagccugau cgaccugcag     3720

gagcugggca aguacgagca guacaucaag uggccuuggu acaucuggcu gggcuucauc     3780

gccggccuga ucgccaucgu gauggugacc aucaugcugu gcugcaugag cgccaucggc     3840

ggcuacaucc ccgaggcccc cagggacggc caggccuacg ugaggaagga cggcgagugg     3900

gugcugcuga gcaccuuccu gugacucgag acuaguagcc aacacccugu cuaaaaaaca     3960

uaaauuucuu uaaucauuuu gccucuuuuc ucugugcuuc aauuaauaaa aaauggaaag     4020

aaccuggauc cgucgacaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4140

aaaaaaaaaa aaaaaaa                                                    4157


<210>  37
<211>  4100
<212>  RNA
<213>  Artificial sequence

<220>
<223>  mRNA sequence of recombinant S protein

<400>  37
aggagacaag cuugucccgc agucggcguc cagcggcucu gcuuguucgu gugugugucg       60

uugcaggccu uauucagauc uaccgguggu accgccacca uggacuggau cuggagaauc      120

cuguuccugg ugggggcugc cacuggcgcc cauagccagu gcgugaaucu gaccaccaga      180

acccagcugc cuccugccua caccaauagc uucaccagag gaguuuauua ucccgauaag      240

guguucagaa guaguguauu acauaguacc caggaccugu uccuaccuuu cuucaguaac      300

gugaccuggu uccacgccau ccacgugagc ggcaccaaug gcaccaagag auucgacaau      360

ccugugcugc cuuucaauga cggcguguac uucgccagca ccgagaagag caauaucauc      420

agaggcugga ucuucggcac caccuuggau uccaagacuc agagccugcu gauuguaaac      480

aacgcuacaa auguggugau caaggugugc gaguuccagu ucugcaauga cccuuuccug      540

gguguuuauu aucauaagaa caacaagagc uggauggaga gcgaguuccg cguauauucg      600

ucggcuaaua auugcaccuu cgaguacgug agccagccuu uccugaugga ccuggagggc      660

aagcagggca auuucaagaa ucugagagag uucguguuca agaauaucga cggcuacuuc      720

aagaucuaca gcaagcacac acccauuaau cuggugagag accugccuca gggcuucagc      780

gcccuggagc cucuggugga ccugccuauc ggcaucaaua ucaccagauu ccagacccug      840

cuggcccugc acagaucaua ucuuacacca ggcgauucgu caagcgguug gaccgcugga      900

gcugcggcau auuacguggg cuaccugcag ccuagaaccu uccugcugaa guacaaugag      960

aaugguacga uaaccgacgc aguugauugu gcccuggacc cucugagcga gaccaagugc     1020

acccugaaga gcuucaccgu ggagaagggc aucuaccaga ccagcaauuu cagagugcag     1080

ccuaccgaga gcaucgugag auucccuaau aucaccaauc ugugcccuuu cggcgaggug     1140

uucaaugcca ccagauucgc cagcguguac gcauggaacc gcaagcggau aagcaauugc     1200

guggccgacu acagcgugcu guacaauagc gccagcuuca gcaccuucaa auguuauggu     1260

guuucgccaa caaagcugaa ugaccugugc uucaccaaug uguacgccga cagcuucgug     1320

aucagaggcg acgaggugag acagaucgcg ccagggcaga ccggcaagau cgccgacuac     1380

aauuacaagc ugccugacga cuucaccggc ugcgugaucg cguggaacuc uaacaaccug     1440

gacucgaaag uuggaggcaa uuacaauuac cuguacagac uguucagaaa gagcaaucug     1500

aagccuuucg agagagacau cagcaccgag aucuaccagg ccggcagcac accguguaau     1560

ggcguggagg gcuucaauug cuacuucccu cugcagagcu acggcuucca gccuaccaau     1620

ggcgugggcu accagccuua cagaguggug gugcugagcu ucgagcugcu gcacgcuccc     1680

gcuaccgugu gcggcccuaa gaagagcacc aaucugguga agaauaagug cgugaauuuc     1740

aauuucaaug gucuaacugg aacgggcgug cugaccgaga gcaauaagaa guuucuuccc     1800

uuucaacaau ucggcagaga caucgccgac accacagaug cuguaagaga cccucagacc     1860

cuggagaucc uggacaucac uccguguagc uucggcggcg ugagcgugau cacaccgggc     1920

accaauacca gcaaucaggu ggccgugcug uaccaggacg ugaauugcac cgaggugccu     1980

guggccaucc acgccgacca gcugacuccc acuuggaggg uauauuccac gggaagcaau     2040

guguuccaga ccagagccgg cugccugauc ggcgccgagc acgugaauaa uagcuacgag     2100

ugcgacaucc cuaucggcgc cggcaucugc gccagcuacc agacccagac caauagcccu     2160

ggcggcagcg gcagcguggc cagccagagc aucaucgccu acaccaugag ccugggcgcc     2220

gagaauagcg uggccuacag caauaauagc aucgccaucc cuaccaauuu caccaucagc     2280

gugaccaccg aaauauuacc agucuccaug accaagacca gcguggacug caccauguac     2340

aucugcggcg acagcaccga gugcagcaau cugcugcugc aguacggcag cuucugcacc     2400

cagcugaaua gagcccugac cggcaucgcc guggagcagg acaagaauac ccaggaggug     2460

uucgcccagg ugaagcagcc agauccaagc aagccuagcg ccaacagcuu caucgaggac     2520

cugcuguuca auaaggugac ccuggccgac gccggcuuca ucaagcagua cggcgacugc     2580

cuaggugaua uugcggcaag agaccugauc ugcgcccaga aguuuaacgg uuugacagua     2640

cuaccuccuc ugcugaccga cgagaugaua gcacaauaua cgucggcauu gcucgcuggc     2700

acgaucacau cgggcuggac uuucggcgcc ggagcagcgu ugcaaauccc uuucgccaug     2760

cagauggccu acagauucaa uggcaucggc gugacccaga augugcugua cgagaaucag     2820

aagcugaucg ccaaucaguu caauagcgcc aucggcaaga uccaggacag ccugagcagc     2880

accgccagcg cccugggcaa gcugcaggac guggugaauc agaaugccca ggcccugaau     2940

acccugguga agcagcugag cagcaauuuc ggcgccauca guaguguacu caacgacauc     3000

cugagcagac uggacccgcc ggaggccgag gugcaaauug aucgucuuau uacuggcaga     3060

cugcagagcc ugcagaccua cgugacccag cagcugauca gagccgccga gaucagagcc     3120

agcgccaauc uggccgccac caagaugagc gagugcgugc ugggccagag caagagagug     3180

gacuucugcg gcaagggcua ccaccugaug agcuucccuc agagcgcucc acauggcgug     3240

guguuccugc acgugaccua cgugccugcc caggagaaga auuucaccac cgcacccgca     3300

aucugccacg acggcaaggc ccacuucccu agagagggcg uguucgugag caauggcacc     3360

cacugguucg ugacccagag aaauuucuac gagccucaga ucaucaccac cgacaauacc     3420

uucgugagcg gcaauugcga cguggugauc gggauaguca auaauacugu cuacgacccu     3480

cugcagccug agcuggacag cuucaaggag gagcuggaca aguacuucaa gaaucacacc     3540

agcccugacg uggaccucgg ugauauuucg ggaaucaaug ccagcguggu gaauauccag     3600

aaggaaauug aucggcucaa cgaaguggcc aagaaucuga augagagccu gaucgaccug     3660

caggagcugg gcaaguacga gcaguacauc aaguggccuu gguacaucug gcugggcuuc     3720

aucgccggcc ugaucgccau cgugauggug accaucaugc ugugcugcau gagcgccauc     3780

ggcggcuaca uccccgaggc ccccagggac ggccaggccu acgugaggaa ggacggcgag     3840

ugggugcugc ugagcaccuu ccugugacuc gagacuagua gccaacaccc ugucuaaaaa     3900

acauaaauuu cuuuaaucau uuugccucuu uucucugugc uucaauuaau aaaaaaugga     3960

aagaaccugg auccgucgac aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4080

aaaaaaaaaa aaaaaaaaaa                                                 4100


<210>  38
<211>  1266
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of recombinant S protein

<400>  38

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Val Ile Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Asn Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
                245                 250                 255     


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
            260                 265                 270         


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
        275                 280                 285             


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
    290                 295                 300                 


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
305                 310                 315                 320 


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
                325                 330                 335     


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
            340                 345                 350         


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
        355                 360                 365             


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
    370                 375                 380                 


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
385                 390                 395                 400 


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
                405                 410                 415     


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
            420                 425                 430         


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Gln Tyr Arg Leu 
        435                 440                 445             


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
    450                 455                 460                 


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
465                 470                 475                 480 


Cys Tyr Ser Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
                485                 490                 495     


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
            500                 505                 510         


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
        515                 520                 525             


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
    530                 535                 540                 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
545                 550                 555                 560 


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
                565                 570                 575     


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
            580                 585                 590         


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val 
        595                 600                 605             


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
    610                 615                 620                 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
625                 630                 635                 640 


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
                645                 650                 655     


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
            660                 665                 670         


Ser Pro Gly Gly Ser Gly Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr 
        675                 680                 685             


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser 
    690                 695                 700                 


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
705                 710                 715                 720 


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
                725                 730                 735     


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
            740                 745                 750         


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
        755                 760                 765             


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
    770                 775                 780                 


Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
785                 790                 795                 800 


Asp Pro Ser Lys Pro Ser Ala Asn Ser Phe Ile Glu Asp Leu Leu Phe 
                805                 810                 815     


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
            820                 825                 830         


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
        835                 840                 845             


Asn Gly Leu Asn Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
    850                 855                 860                 


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr 
865                 870                 875                 880 


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
                885                 890                 895     


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
            900                 905                 910         


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
        915                 920                 925             


Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val 
    930                 935                 940                 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
945                 950                 955                 960 


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
                965                 970                 975     


Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly 
            980                 985                 990         


Arg Leu Gln Ser Leu Gln Thr Tyr  Val Thr Gln Gln Leu  Ile Arg Ala 
        995                 1000                 1005             


Ala Glu  Ile Arg Ala Ser Ala  Asn Leu Ala Ala Thr  Lys Met Ser 
    1010                 1015                 1020             


Glu Cys  Val Leu Gly Gln Ser  Lys Arg Val Asp Phe  Cys Gly Lys 
    1025                 1030                 1035             


Gly Tyr  His Leu Met Ser Phe  Pro Gln Ser Ala Pro  His Gly Val 
    1040                 1045                 1050             


Val Phe  Leu His Val Thr Tyr  Val Pro Ala Gln Glu  Lys Asn Phe 
    1055                 1060                 1065             


Thr Thr  Ala Pro Ala Ile Cys  His Asp Gly Lys Ala  His Phe Pro 
    1070                 1075                 1080             


Arg Glu  Gly Val Phe Val Ser  Asn Gly Thr His Trp  Phe Val Thr 
    1085                 1090                 1095             


Gln Arg  Asn Phe Tyr Glu Pro  Gln Ile Ile Thr Thr  Asp Asn Thr 
    1100                 1105                 1110             


Phe Val  Ser Gly Asn Cys Asp  Val Val Ile Gly Ile  Val Asn Asn 
    1115                 1120                 1125             


Thr Val  Tyr Asp Pro Leu Gln  Pro Glu Leu Asp Ser  Phe Lys Glu 
    1130                 1135                 1140             


Glu Leu  Asp Lys Tyr Phe Lys  Asn His Thr Ser Pro  Asp Val Asp 
    1145                 1150                 1155             


Leu Gly  Asp Ile Ser Gly Ile  Asn Ala Ser Val Val  Asn Ile Gln 
    1160                 1165                 1170             


Lys Glu  Ile Asp Arg Leu Asn  Glu Val Ala Lys Asn  Leu Asn Glu 
    1175                 1180                 1185             


Ser Leu  Ile Asp Leu Gln Glu  Leu Gly Lys Tyr Glu  Gln Tyr Ile 
    1190                 1195                 1200             


Lys Trp  Pro Trp Tyr Ile Trp  Leu Gly Phe Ile Ala  Gly Leu Ile 
    1205                 1210                 1215             


Ala Ile  Val Met Val Thr Ile  Met Leu Cys Cys Met  Thr Ser Cys 
    1220                 1225                 1230             


Cys Ser  Cys Leu Lys Gly Cys  Cys Ser Cys Gly Ser  Cys Cys Lys 
    1235                 1240                 1245             


Phe Asp  Glu Asp Asp Ser Glu  Pro Val Leu Lys Gly  Val Lys Leu 
    1250                 1255                 1260             


His Tyr  Thr 
    1265     


<210>  39
<211>  1266
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of recombinant S protein

<400>  39

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Val Ile Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Asn Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
                245                 250                 255     


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
            260                 265                 270         


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
        275                 280                 285             


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
    290                 295                 300                 


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
305                 310                 315                 320 


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
                325                 330                 335     


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
            340                 345                 350         


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
        355                 360                 365             


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
    370                 375                 380                 


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
385                 390                 395                 400 


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
                405                 410                 415     


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
            420                 425                 430         


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Gln Tyr Arg Leu 
        435                 440                 445             


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
    450                 455                 460                 


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
465                 470                 475                 480 


Cys Tyr Ser Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
                485                 490                 495     


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
            500                 505                 510         


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
        515                 520                 525             


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
    530                 535                 540                 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
545                 550                 555                 560 


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
                565                 570                 575     


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
            580                 585                 590         


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val 
        595                 600                 605             


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
    610                 615                 620                 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
625                 630                 635                 640 


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
                645                 650                 655     


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
            660                 665                 670         


Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr 
        675                 680                 685             


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser 
    690                 695                 700                 


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
705                 710                 715                 720 


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
                725                 730                 735     


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
            740                 745                 750         


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
        755                 760                 765             


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
    770                 775                 780                 


Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
785                 790                 795                 800 


Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe 
                805                 810                 815     


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
            820                 825                 830         


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
        835                 840                 845             


Asn Gly Leu Asn Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
    850                 855                 860                 


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr 
865                 870                 875                 880 


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
                885                 890                 895     


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
            900                 905                 910         


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
        915                 920                 925             


Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val 
    930                 935                 940                 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
945                 950                 955                 960 


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
                965                 970                 975     


Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly 
            980                 985                 990         


Arg Leu Gln Ser Leu Gln Thr Tyr  Val Thr Gln Gln Leu  Ile Arg Ala 
        995                 1000                 1005             


Ala Glu  Ile Arg Ala Ser Ala  Asn Leu Ala Ala Thr  Lys Met Ser 
    1010                 1015                 1020             


Glu Cys  Val Leu Gly Gln Ser  Lys Arg Val Asp Phe  Cys Gly Lys 
    1025                 1030                 1035             


Gly Tyr  His Leu Met Ser Phe  Pro Gln Ser Ala Pro  His Gly Val 
    1040                 1045                 1050             


Val Phe  Leu His Val Thr Tyr  Val Pro Ala Gln Glu  Lys Asn Phe 
    1055                 1060                 1065             


Thr Thr  Ala Pro Ala Ile Cys  His Asp Gly Lys Ala  His Phe Pro 
    1070                 1075                 1080             


Arg Glu  Gly Val Phe Val Ser  Asn Gly Thr His Trp  Phe Val Thr 
    1085                 1090                 1095             


Gln Arg  Asn Phe Tyr Glu Pro  Gln Ile Ile Thr Thr  Asp Asn Thr 
    1100                 1105                 1110             


Phe Val  Ser Gly Asn Cys Asp  Val Val Ile Gly Ile  Val Asn Asn 
    1115                 1120                 1125             


Thr Val  Tyr Asp Pro Leu Gln  Pro Glu Leu Asp Ser  Phe Lys Glu 
    1130                 1135                 1140             


Glu Leu  Asp Lys Tyr Phe Lys  Asn His Thr Ser Pro  Asp Val Asp 
    1145                 1150                 1155             


Leu Gly  Asp Ile Ser Gly Ile  Asn Ala Ser Val Val  Asn Ile Gln 
    1160                 1165                 1170             


Lys Glu  Ile Asp Arg Leu Asn  Glu Val Ala Lys Asn  Leu Asn Glu 
    1175                 1180                 1185             


Ser Leu  Ile Asp Leu Gln Glu  Leu Gly Lys Tyr Glu  Gln Tyr Ile 
    1190                 1195                 1200             


Lys Trp  Pro Trp Tyr Ile Trp  Leu Gly Phe Ile Ala  Gly Leu Ile 
    1205                 1210                 1215             


Ala Ile  Val Met Val Thr Ile  Met Leu Cys Cys Met  Thr Ser Cys 
    1220                 1225                 1230             


Cys Ser  Cys Leu Lys Gly Cys  Cys Ser Cys Gly Ser  Cys Cys Lys 
    1235                 1240                 1245             


Phe Asp  Glu Asp Asp Ser Glu  Pro Val Leu Lys Gly  Val Lys Leu 
    1250                 1255                 1260             


His Tyr  Thr 
    1265     


<210>  40
<211>  1266
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of recombinant S protein

<400>  40

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Val Ile Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Asn Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
                245                 250                 255     


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
            260                 265                 270         


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
        275                 280                 285             


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
    290                 295                 300                 


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
305                 310                 315                 320 


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
                325                 330                 335     


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
            340                 345                 350         


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
        355                 360                 365             


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
    370                 375                 380                 


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
385                 390                 395                 400 


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
                405                 410                 415     


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
            420                 425                 430         


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Gln Tyr Arg Leu 
        435                 440                 445             


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
    450                 455                 460                 


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
465                 470                 475                 480 


Cys Tyr Ser Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
                485                 490                 495     


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
            500                 505                 510         


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
        515                 520                 525             


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
    530                 535                 540                 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
545                 550                 555                 560 


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
                565                 570                 575     


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
            580                 585                 590         


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val 
        595                 600                 605             


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
    610                 615                 620                 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
625                 630                 635                 640 


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
                645                 650                 655     


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
            660                 665                 670         


Ser Pro Gly Gly Ser Gly Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr 
        675                 680                 685             


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser 
    690                 695                 700                 


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
705                 710                 715                 720 


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
                725                 730                 735     


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
            740                 745                 750         


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
        755                 760                 765             


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
    770                 775                 780                 


Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
785                 790                 795                 800 


Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe 
                805                 810                 815     


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
            820                 825                 830         


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
        835                 840                 845             


Asn Gly Leu Asn Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
    850                 855                 860                 


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr 
865                 870                 875                 880 


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
                885                 890                 895     


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
            900                 905                 910         


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
        915                 920                 925             


Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val 
    930                 935                 940                 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
945                 950                 955                 960 


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
                965                 970                 975     


Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly 
            980                 985                 990         


Arg Leu Gln Ser Leu Gln Thr Tyr  Val Thr Gln Gln Leu  Ile Arg Ala 
        995                 1000                 1005             


Ala Glu  Ile Arg Ala Ser Ala  Asn Leu Ala Ala Thr  Lys Met Ser 
    1010                 1015                 1020             


Glu Cys  Val Leu Gly Gln Ser  Lys Arg Val Asp Phe  Cys Gly Lys 
    1025                 1030                 1035             


Gly Tyr  His Leu Met Ser Phe  Pro Gln Ser Ala Pro  His Gly Val 
    1040                 1045                 1050             


Val Phe  Leu His Val Thr Tyr  Val Pro Ala Gln Glu  Lys Asn Phe 
    1055                 1060                 1065             


Thr Thr  Ala Pro Ala Ile Cys  His Asp Gly Lys Ala  His Phe Pro 
    1070                 1075                 1080             


Arg Glu  Gly Val Phe Val Ser  Asn Gly Thr His Trp  Phe Val Thr 
    1085                 1090                 1095             


Gln Arg  Asn Phe Tyr Glu Pro  Gln Ile Ile Thr Thr  Asp Asn Thr 
    1100                 1105                 1110             


Phe Val  Ser Gly Asn Cys Asp  Val Val Ile Gly Ile  Val Asn Asn 
    1115                 1120                 1125             


Thr Val  Tyr Asp Pro Leu Gln  Pro Glu Leu Asp Ser  Phe Lys Glu 
    1130                 1135                 1140             


Glu Leu  Asp Lys Tyr Phe Lys  Asn His Thr Ser Pro  Asp Val Asp 
    1145                 1150                 1155             


Leu Gly  Asp Ile Ser Gly Ile  Asn Ala Ser Val Val  Asn Ile Gln 
    1160                 1165                 1170             


Lys Glu  Ile Asp Arg Leu Asn  Glu Val Ala Lys Asn  Leu Asn Glu 
    1175                 1180                 1185             


Ser Leu  Ile Asp Leu Gln Glu  Leu Gly Lys Tyr Glu  Gln Tyr Ile 
    1190                 1195                 1200             


Lys Trp  Pro Trp Tyr Ile Trp  Leu Gly Phe Ile Ala  Gly Leu Ile 
    1205                 1210                 1215             


Ala Ile  Val Met Val Thr Ile  Met Leu Cys Cys Met  Thr Ser Cys 
    1220                 1225                 1230             


Cys Ser  Cys Leu Lys Gly Cys  Cys Ser Cys Gly Ser  Cys Cys Lys 
    1235                 1240                 1245             


Phe Asp  Glu Asp Asp Ser Glu  Pro Val Leu Lys Gly  Val Lys Leu 
    1250                 1255                 1260             


His Tyr  Thr 
    1265     


<210>  41
<211>  1266
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of recombinant S protein

<400>  41

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Val Ile Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Asn Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
                245                 250                 255     


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
            260                 265                 270         


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
        275                 280                 285             


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
    290                 295                 300                 


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
305                 310                 315                 320 


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
                325                 330                 335     


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
            340                 345                 350         


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
        355                 360                 365             


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
    370                 375                 380                 


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
385                 390                 395                 400 


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
                405                 410                 415     


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
            420                 425                 430         


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Gln Tyr Arg Leu 
        435                 440                 445             


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
    450                 455                 460                 


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
465                 470                 475                 480 


Cys Tyr Ser Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
                485                 490                 495     


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
            500                 505                 510         


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
        515                 520                 525             


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
    530                 535                 540                 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
545                 550                 555                 560 


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
                565                 570                 575     


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
            580                 585                 590         


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val 
        595                 600                 605             


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
    610                 615                 620                 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
625                 630                 635                 640 


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
                645                 650                 655     


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
            660                 665                 670         


Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr 
        675                 680                 685             


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser 
    690                 695                 700                 


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
705                 710                 715                 720 


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
                725                 730                 735     


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
            740                 745                 750         


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
        755                 760                 765             


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
    770                 775                 780                 


Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
785                 790                 795                 800 


Asp Pro Ser Lys Pro Ser Ala Asn Ser Phe Ile Glu Asp Leu Leu Phe 
                805                 810                 815     


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
            820                 825                 830         


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
        835                 840                 845             


Asn Gly Leu Asn Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
    850                 855                 860                 


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr 
865                 870                 875                 880 


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
                885                 890                 895     


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
            900                 905                 910         


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
        915                 920                 925             


Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val 
    930                 935                 940                 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
945                 950                 955                 960 


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
                965                 970                 975     


Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly 
            980                 985                 990         


Arg Leu Gln Ser Leu Gln Thr Tyr  Val Thr Gln Gln Leu  Ile Arg Ala 
        995                 1000                 1005             


Ala Glu  Ile Arg Ala Ser Ala  Asn Leu Ala Ala Thr  Lys Met Ser 
    1010                 1015                 1020             


Glu Cys  Val Leu Gly Gln Ser  Lys Arg Val Asp Phe  Cys Gly Lys 
    1025                 1030                 1035             


Gly Tyr  His Leu Met Ser Phe  Pro Gln Ser Ala Pro  His Gly Val 
    1040                 1045                 1050             


Val Phe  Leu His Val Thr Tyr  Val Pro Ala Gln Glu  Lys Asn Phe 
    1055                 1060                 1065             


Thr Thr  Ala Pro Ala Ile Cys  His Asp Gly Lys Ala  His Phe Pro 
    1070                 1075                 1080             


Arg Glu  Gly Val Phe Val Ser  Asn Gly Thr His Trp  Phe Val Thr 
    1085                 1090                 1095             


Gln Arg  Asn Phe Tyr Glu Pro  Gln Ile Ile Thr Thr  Asp Asn Thr 
    1100                 1105                 1110             


Phe Val  Ser Gly Asn Cys Asp  Val Val Ile Gly Ile  Val Asn Asn 
    1115                 1120                 1125             


Thr Val  Tyr Asp Pro Leu Gln  Pro Glu Leu Asp Ser  Phe Lys Glu 
    1130                 1135                 1140             


Glu Leu  Asp Lys Tyr Phe Lys  Asn His Thr Ser Pro  Asp Val Asp 
    1145                 1150                 1155             


Leu Gly  Asp Ile Ser Gly Ile  Asn Ala Ser Val Val  Asn Ile Gln 
    1160                 1165                 1170             


Lys Glu  Ile Asp Arg Leu Asn  Glu Val Ala Lys Asn  Leu Asn Glu 
    1175                 1180                 1185             


Ser Leu  Ile Asp Leu Gln Glu  Leu Gly Lys Tyr Glu  Gln Tyr Ile 
    1190                 1195                 1200             


Lys Trp  Pro Trp Tyr Ile Trp  Leu Gly Phe Ile Ala  Gly Leu Ile 
    1205                 1210                 1215             


Ala Ile  Val Met Val Thr Ile  Met Leu Cys Cys Met  Thr Ser Cys 
    1220                 1225                 1230             


Cys Ser  Cys Leu Lys Gly Cys  Cys Ser Cys Gly Ser  Cys Cys Lys 
    1235                 1240                 1245             


Phe Asp  Glu Asp Asp Ser Glu  Pro Val Leu Lys Gly  Val Lys Leu 
    1250                 1255                 1260             


His Tyr  Thr 
    1265     


<210>  42
<211>  1266
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of recombinant S protein

<400>  42

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Val Ile Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Asn Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
                245                 250                 255     


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
            260                 265                 270         


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
        275                 280                 285             


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
    290                 295                 300                 


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
305                 310                 315                 320 


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
                325                 330                 335     


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
            340                 345                 350         


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
        355                 360                 365             


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
    370                 375                 380                 


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
385                 390                 395                 400 


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
                405                 410                 415     


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
            420                 425                 430         


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Gln Tyr Arg Leu 
        435                 440                 445             


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
    450                 455                 460                 


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
465                 470                 475                 480 


Cys Tyr Ser Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
                485                 490                 495     


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
            500                 505                 510         


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
        515                 520                 525             


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
    530                 535                 540                 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
545                 550                 555                 560 


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
                565                 570                 575     


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
            580                 585                 590         


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val 
        595                 600                 605             


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
    610                 615                 620                 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
625                 630                 635                 640 


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
                645                 650                 655     


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
            660                 665                 670         


Ser Pro Gly Gly Ser Gly Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr 
        675                 680                 685             


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser 
    690                 695                 700                 


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
705                 710                 715                 720 


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
                725                 730                 735     


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
            740                 745                 750         


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
        755                 760                 765             


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
    770                 775                 780                 


Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
785                 790                 795                 800 


Asp Pro Ser Lys Pro Ser Ala Asn Ser Phe Ile Glu Asp Leu Leu Phe 
                805                 810                 815     


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
            820                 825                 830         


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
        835                 840                 845             


Asn Gly Leu Asn Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
    850                 855                 860                 


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr 
865                 870                 875                 880 


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
                885                 890                 895     


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
            900                 905                 910         


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
        915                 920                 925             


Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val 
    930                 935                 940                 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
945                 950                 955                 960 


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
                965                 970                 975     


Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly 
            980                 985                 990         


Arg Leu Gln Ser Leu Gln Thr Tyr  Val Thr Gln Gln Leu  Ile Arg Ala 
        995                 1000                 1005             


Ala Glu  Ile Arg Ala Ser Ala  Asn Leu Ala Ala Thr  Lys Met Ser 
    1010                 1015                 1020             


Glu Cys  Val Leu Gly Gln Ser  Lys Arg Val Asp Phe  Cys Gly Lys 
    1025                 1030                 1035             


Gly Tyr  His Leu Met Ser Phe  Pro Gln Ser Ala Pro  His Gly Val 
    1040                 1045                 1050             


Val Phe  Leu His Val Thr Tyr  Val Pro Ala Gln Glu  Lys Asn Phe 
    1055                 1060                 1065             


Thr Thr  Ala Pro Ala Ile Cys  His Asp Gly Lys Ala  His Phe Pro 
    1070                 1075                 1080             


Arg Glu  Gly Val Phe Val Ser  Asn Gly Thr His Trp  Phe Val Thr 
    1085                 1090                 1095             


Gln Arg  Asn Phe Tyr Glu Pro  Gln Ile Ile Thr Thr  Asp Asn Thr 
    1100                 1105                 1110             


Phe Val  Ser Gly Asn Cys Asp  Val Val Ile Gly Ile  Val Asn Asn 
    1115                 1120                 1125             


Thr Val  Tyr Asp Pro Leu Gln  Pro Glu Leu Asp Ser  Phe Lys Glu 
    1130                 1135                 1140             


Glu Leu  Asp Lys Tyr Phe Lys  Asn His Thr Ser Pro  Asp Val Asp 
    1145                 1150                 1155             


Leu Gly  Asp Ile Ser Gly Ile  Asn Ala Ser Val Val  Asn Ile Gln 
    1160                 1165                 1170             


Lys Glu  Ile Asp Arg Leu Asn  Glu Val Ala Lys Asn  Leu Asn Glu 
    1175                 1180                 1185             


Ser Leu  Ile Asp Leu Gln Glu  Leu Gly Lys Tyr Glu  Gln Tyr Ile 
    1190                 1195                 1200             


Lys Trp  Pro Trp Tyr Ile Trp  Leu Gly Phe Ile Ala  Gly Leu Ile 
    1205                 1210                 1215             


Ala Ile  Val Met Val Thr Ile  Met Leu Cys Cys Met  Thr Ser Cys 
    1220                 1225                 1230             


Cys Ser  Cys Leu Lys Gly Cys  Cys Ser Cys Gly Ser  Cys Cys Lys 
    1235                 1240                 1245             


Phe Asp  Glu Asp Asp Ser Glu  Pro Val Leu Lys Gly  Val Lys Leu 
    1250                 1255                 1260             


His Tyr  Thr 
    1265     


<210>  43
<211>  4115
<212>  RNA
<213>  Artificial sequence

<220>
<223>  mRNA sequence of RBMRNA-Lambda vaccine

<400>  43
augagacaag cuugucccgc agucggcguc cagcggcucu gcuuguucgu gugugugucg       60

uugcaggccu uauucagauc uaccgguggu accgccacca uguucguguu ccuggugcug      120

cugccucugg ugagcagcca gugcgugaau cugaccacca gaacccagcu gccuccugcc      180

uacaccaaua gcuucaccag aggaguuuau uaucccgaua agguguucag aaguagugua      240

uuacauagua cccaggaccu guuccuaccu uucuucagua acgugaccug guuccacgcc      300

auccacguga gcggcaccaa ugucaucaag agauucgaca auccugugcu gccuuucaau      360

gacggcgugu acuucgccag caccgagaag agcaauauca ucagaggcug gaucuucggc      420

accaccuugg auuccaagac ucagagccug cugauuguaa acaacgcuac aaauguggug      480

aucaaggugu gcgaguucca guucugcaau gacccuuucc uggguguuua uuaucauaag      540

aacaacaaga gcuggaugga gagcgaguuc cgcguauauu cgucggcuaa uaauugcacc      600

uucgaguacg ugagccagcc uuuccugaug gaccuggagg gcaagcaggg caauuucaag      660

aaucugagag aguucguguu caagaauauc gacggcuacu ucaagaucua cagcaagcac      720

acacccauua aucuggugag agaccugccu cagggcuuca gcgcccugga gccucuggug      780

gaccugccua ucggcaucaa uaucaccaga uuccagaccc ugcuggcccu gcacaacucg      840

ucaagcgguu ggaccgcugg agcugcggca uauuacgugg gcuaccugca gccuagaacc      900

uuccugcuga aguacaauga gaaugguacg auaaccgacg caguugauug ugcccuggac      960

ccucugagcg agaccaagug cacccugaag agcuucaccg uggagaaggg caucuaccag     1020

accagcaauu ucagagugca gccuaccgag agcaucguga gauucccuaa uaucaccaau     1080

cugugcccuu ucggcgaggu guucaaugcc accagauucg ccagcgugua cgcauggaac     1140

cgcaagcgga uaagcaauug cguggccgac uacagcgugc uguacaauag cgccagcuuc     1200

agcaccuuca aauguuaugg uguuucgcca acaaagcuga augaccugug cuucaccaau     1260

guguacgccg acagcuucgu gaucagaggc gacgagguga gacagaucgc gccagggcag     1320

accggcaaga ucgccgacua caauuacaag cugccugacg acuucaccgg cugcgugauc     1380

gcguggaacu cuaacaaccu ggacucgaaa guuggaggca auuacaauua ccaguacaga     1440

cuguucagaa agagcaaucu gaagccuuuc gagagagaca ucagcaccga gaucuaccag     1500

gccggcagca caccguguaa uggcguggag ggcuucaauu gcuacucccc ucugcagagc     1560

uacggcuucc agccuaccaa uggcgugggc uaccagccuu acagaguggu ggugcugagc     1620

uucgagcugc ugcacgcucc cgcuaccgug ugcggcccua agaagagcac caaucuggug     1680

aagaauaagu gcgugaauuu caauuucaau ggucuaacug gaacgggcgu gcugaccgag     1740

agcaauaaga aguuucuucc cuuucaacaa uucggcagag acaucgccga caccacagau     1800

gcuguaagag acccucagac ccuggagauc cuggacauca cuccguguag cuucggcggc     1860

gugagcguga ucacaccggg caccaauacc agcaaucagg uggccgugcu guaccagggc     1920

gugaauugca ccgaggugcc uguggccauc cacgccgacc agcugacucc cacuuggagg     1980

guauauucca cgggaagcaa uguguuccag accagagccg gcugccugau cggcgccgag     2040

cacgugaaua auagcuacga gugcgacauc ccuaucggcg ccggcaucug cgccagcuac     2100

cagacccaga ccaauagccc uggcggcagc ggcagcgugg ccagccagag caucaucgcc     2160

uacaccauga gccugggcgc cgagaauagc guggccuaca gcaauaauag caucgccauc     2220

ccuaccaauu ucaccaucag cgugaccacc gaaauauuac cagucuccau gaccaagacc     2280

agcguggacu gcaccaugua caucugcggc gacagcaccg agugcagcaa ucugcugcug     2340

caguacggca gcuucugcac ccagcugaau agagcccuga ccggcaucgc cguggagcag     2400

gacaagaaua cccaggaggu guucgcccag gugaagcaga ucuacaagac uccgccgauc     2460

aaggacuucg gcggcuucaa uuucagccaa auacucccag auccaagcaa gccuagcgcc     2520

aacagcuuca ucgaggaccu gcuguucaau aaggugaccc uggccgacgc cggcuucauc     2580

aagcaguacg gcgacugccu aggugauauu gcggcaagag accugaucug cgcccagaag     2640

uuuaacgguu ugaacguacu accuccucug cugaccgacg agaugauagc acaauauacg     2700

ucggcauugc ucgcuggcac gaucacaucg ggcuggacuu ucggcgccgg agcagcguug     2760

caaaucccuu ucgccaugca gauggccuac agauucaaug gcaucggcgu gacccagaau     2820

gugcuguacg agaaucagaa gcugaucgcc aaucaguuca auagcgccau cggcaagauc     2880

caggacagcc ugagcagcac cgccagcgcc cugggcaagc ugcaggacgu ggugaaucag     2940

aaugcccagg cccugaauac ccuggugaag cagcugagca gcaauuucgg cgccaucagu     3000

aguguacuca acgacauccu gagcagacug gacccaccag aggccgaggu gcaaauugau     3060

cgucuuauua cuggcagacu gcagagccug cagaccuacg ugacccagca gcugaucaga     3120

gccgccgaga ucagagccag cgccaaucug gccgccacca agaugagcga gugcgugcug     3180

ggccagagca agagagugga cuucugcggc aagggcuacc accugaugag cuucccucag     3240

agcgcuccac auggcguggu guuccugcac gugaccuacg ugccugccca ggagaagaau     3300

uucaccaccg cacccgcaau cugccacgac ggcaaggccc acuucccuag agagggcgug     3360

uucgugagca auggcaccca cugguucgug acccagagaa auuucuacga gccucagauc     3420

aucaccaccg acaauaccuu cgugagcggc aauugcgacg uggugaucgg gauagucaau     3480

aauacugucu acgacccucu gcagccugag cuggacagcu ucaaggagga gcuggacaag     3540

uacuucaaga aucacaccag cccugacgug gaccucggug auauuucggg aaucaaugcc     3600

agcgugguga auauccagaa ggaaauugau cggcucaacg aaguggccaa gaaucugaau     3660

gagagccuga ucgaccugca ggagcugggc aaguacgagc aguacaucaa guggccuugg     3720

uacaucuggc ugggcuucau cgccggccug aucgccaucg ugauggugac caucaugcug     3780

ugcugcauga ccuccuguug uuccuguuug aaaggguguu guucgugugg guccugcugc     3840

aaguucgacg aggacgacag cgagccugug cugaagggcg ugaagcugca cuacaccuaa     3900

cucgagacua guagccaaca cccugucuaa aaaacauaaa uuucuuuaau cauuuugccu     3960

cuuuucucug ugcuucaauu aauaaaaaau ggaaagaacc uaaaaaaaaa aaaaaaaaaa     4020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                                4115


