                         SEQUENCE LISTING

<110>  TSINGHUA UNIVERSITY
 
<120>  chaperones as an autophagy receptors for clearances of protein 
       aggregates and/or aggregation-prone proteins

<130>  BI3212632P

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  1608
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1

<400>  1
atggcgtccc tttcccttgc acctgttaac atctttaagg caggagctga tgaagagaga       60

gcagagacag ctcgtctgac ttcttttatt ggtgccatcg ccattggaga cttggtaaag      120

agcaccttgg gacccaaagg catggacaaa attcttctaa gcagtggacg agatgcctct      180

cttatggtaa ccaatgatgg tgccactatt ctaaaaaaca ttggtgttga caatccagca      240

gctaaagttt tagttgatat gtcaagggtt caagatgatg aagttggtga tggcactacc      300

tctgttaccg ttttagcagc agaattatta agggaagcag aatctttaat tgcaaaaaag      360

attcatccac agaccatcat agcgggttgg agagaagcca cgaaggctgc aagagaggcg      420

ctgttgagtt ctgcagttga tcatggttcc gatgaagtta aattccgtca agatttaatg      480

aatattgcgg gcacaacatt atcctcaaaa cttcttactc atcacaaaga ccactttaca      540

aagttagctg tagaagcagt tctcagactg aaaggctctg gcaacctgga ggcaattcat      600

attatcaaga agctaggagg aagtttggca gattcctatt tagatgaagg cttcctgttg      660

gataaaaaaa ttggagtaaa tcaaccaaaa cgaattgaaa atgctaaaat tcttattgca      720

aatactggta tggatacaga caaaataaag atatttggtt cccgggtaag agttgactct      780

acagcaaagg ttgcagaaat agaacatgcg gaaaaggaaa aaatgaagga gaaagttgaa      840

cgtattctta agcatggaat aaattgcttt attaacaggc aattaattta taattatcct      900

gaacagctct ttggtgctgc tggtgtcatg gctattgagc atgcagattt tgcaggtgtg      960

gaacgcctag ctcttgtcac aggtggtgaa attgcctcta cctttgatca cccagaactg     1020

gtgaagcttg gaagttgcaa acttatcgag gaagtcatga ttggagaaga caaactcatt     1080

cacttttctg gggttgccct tggtgaggct tgtaccattg ttttgcgtgg tgccactcaa     1140

caaattttag atgaagcaga aagatcattg catgatgctc tttgtgttct tgcgcaaact     1200

gtaaaggact ctagaacagt ttatggagga ggctgttctg agatgttgat ggctcatgct     1260

gtgacacagc ttgccaatag aacaccaggc aaagaagctg ttgcaatgga gtcttatgct     1320

aaagcactga gaatgttgcc aaccatcata gctgacaatg caggctatga cagtgcagac     1380

ctggtggcac agctcagggc tgctcacagt gaaggcaata ccactgctgg attggatatg     1440

agggaaggca ccattggaga tatggctatc ctgggtataa cagaaagttt tcaagtgaag     1500

cgacaggttc ttctgagtgc agctgaagca gcagaggtga ttctgcgtgt ggacaacatc     1560

atcaaagcgg cacccaggaa acgtgtccct gatcaccacc cctgttaa                  1608


<210>  2
<211>  1596
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2

<400>  2
atggcggcgg tgaagaccct gaaccccaag gccgaggtgg cccgagcgca ggcggcgctg       60

gcggtcaaca tcagcgcagc gcggggtctg caggacgtgc taaggaccaa cctggggccc      120

aagggcacca tgaagatgct cgtttctggc gctggagaca tcaaacttac taaagacggc      180

aatgtgctgc ttcacgaaat gcaaattcaa cacccaacag cttccttaat agcaaaggta      240

gcaacagccc aggatgatat aactggtgat ggtacgactt ctaatgtcct aatcattgga      300

gagctgctga aacaggcgga tctctacatt tctgaaggcc ttcatcctag aataatcact      360

gaaggatttg aagctgcaaa ggaaaaggcc cttcagtttt tggaagaagt caaagtaagc      420

agagagatgg acagggaaac acttatagat gtggccagaa catctcttcg tactaaagtt      480

catgctgaac ttgcagatgt cttaacagag gctgtagtgg actccatttt ggccattaaa      540

aagcaagatg aacctattga tctcttcatg attgagatca tggagatgaa acataaatct      600

gaaactgata caagcttaat cagagggctt gttttggacc acggagcacg gcatcctgat      660

atgaagaaaa gggtggagga tgcatacatc ctcacttgta acgtgtcatt agagtatgag      720

aaaacagaag tgaattctgg ctttttttac aagagtgcag aagagagaga aaaactcgtg      780

aaagctgaaa gaaaattcat tgaagatagg gttaaaaaaa taatagaact gaaaaggaaa      840

gtctgtggcg attcagataa aggatttgtt gttattaatc aaaagggaat tgaccccttt      900

tccttagatg ctctttcaaa agaaggcata gttgctctgc gcagagctaa aaggagaaat      960

atggagaggc tgactcttgc ttgtggtggg gtagccctga attcttttga cgacctaagt     1020

cctgactgct tgggacatgc aggacttgta tatgagtata cattgggaga agagaagttt     1080

acctttattg agaaatgtaa caaccctcgt tctgtcacat tattgatcaa aggaccaaat     1140

aagcacacac tcactcagat caaagatgca gtgagggacg gcttgagggc tgtcaaaaat     1200

gctattgatg atggctgtgt ggttccaggt gctggtgccg tggaagtggc aatggcagaa     1260

gccctgatta aacataagcc cagtgtaaag ggcagggcac agcttggagt ccaagcattt     1320

gctgatgcat tgctcattat tcccaaggtt cttgctcaga actctggttt tgaccttcag     1380

gaaacattag ttaaaattca agcagaacat tcagaatcag gtcagcttgt gggtgtggac     1440

ctgaacacag gtgagccaat ggtggcagca gaagtaggcg tatgggataa ctattgtgta     1500

aagaaacagc ttcttcactc ctgcactgtg attgccacca acattctctt ggttgatgag     1560

atcatgcgag ctggaatgtc ttctctgaaa ggttga                               1596


<210>  3
<211>  1671
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3

<400>  3
atggaggggc ctttgtccgt gttcggtgac cgcagcactg gggaaacgat ccgctcccaa       60

aacgttatgg ctgcagcttc gattgccaat attgtaaaaa gttctcttgg tccagttggc      120

ttggataaaa tgttggtgga tgatattggt gatgtaacca ttactaacga tggtgcaacc      180

atcctgaagt tactggaggt agaacatcct gcagctaaag ttctttgtga gctggctgat      240

ctgcaagaca aagaagttgg agatggaact acttcagtgg ttattattgc agcagaactc      300

ctaaaaaatg cagatgaatt agtcaaacag aaaattcatc ccacatcagt tattagtggc      360

tatcgacttg cttgcaagga agcagtgcgt tatatcaatg aaaacctaat tgttaacaca      420

gatgaactgg gaagagattg cctgattaat gctgctaaga catccatgtc ttccaaaatc      480

attggaataa atggtgattt ctttgctaac atggtagtag atgctgtact tgctattaaa      540

tacacagaca taagaggcca gccacgctat ccagtcaact ctgttaatat tttgaaagcc      600

catgggagaa gtcaaatgga gagtatgctc atcagtggct atgcactcaa ctgtgtggtg      660

ggatcccagg gcatgcccaa gagaatcgta aatgcaaaaa ttgcttgcct tgacttcagc      720

ctgcaaaaaa caaaaatgaa gcttggtgta caggtggtca ttacagaccc tgaaaaactg      780

gaccaaatta gacagagaga atcagatatc accaaggaga gaattcagaa gatcctggca      840

actggtgcca atgttattct aaccactggt ggaattgatg atatgtgtct gaagtatttt      900

gtggaggctg gtgctatggc agttagaaga gttttaaaaa gggaccttaa acgcattgcc      960

aaagcttctg gagcaactat tctgtcaacc ctggccaatt tggaaggtga agaaactttt     1020

gaagctgcaa tgttgggaca ggcagaagaa gtggtacagg agagaatttg tgatgatgag     1080

ctgatcttaa tcaaaaatac taaggctcgt acgtctgcat cgattatctt acgtggggca     1140

aatgatttca tgtgtgatga gatggagcgc tctttacatg atgcactttg tgtagtgaag     1200

agagttttgg agtcaaaatc tgtggttccc ggtgggggtg ctgtagaagc agccctttcc     1260

atataccttg aaaactatgc aaccagcatg gggtctcggg aacagcttgc gattgcagag     1320

tttgcaagat cacttcttgt tattcccaat acactagcag ttaatgctgc ccaggactcc     1380

acagatctgg ttgcaaaatt aagagctttt cataatgagg cccaggttaa cccagaacgt     1440

aaaaatctaa aatggattgg tcttgatttg agcaatggta aacctcgaga caacaaacaa     1500

gcaggggtgt ttgaaccaac catagttaaa gttaagagtt tgaaatttgc aacagaagct     1560

gcaatcacca ttcttcgaat tgatgatctt attaaattac atccagaaag taaagatgat     1620

aaacatggaa gttatgaaga tgctgttcac tctggagccc ttaatgattg a              1671


<210>  4
<211>  1638
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4

<400>  4
atgatgggcc atcgtccagt gctcgtgctc agccagaaca caaagcgtga atccggaaga       60

aaagttcaat ctggaaacat caatgctgcc aagactattg cagatatcat ccgaacatgt      120

ttgggaccca agtccatgat gaagatgctt ttggacccaa tgggaggcat tgtgatgacc      180

aatgatggca atgccattct tcgagagatt caagtccagc atccagcggc caagtccatg      240

atcgaaatta gccggaccca ggatgaagag gttggagatg ggaccacatc agtaattatt      300

cttgcagggg aaatgctgtc tgtagctgag cacttcctgg agcagcagat gcacccaaca      360

gtggtgatca gtgcttaccg caaggcattg gatgatatga tcagcaccct aaagaaaata      420

agtatcccag tcgacatcag tgacagtgat atgatgctga acatcatcaa cagctctatt      480

actaccaaag ccatcagtcg gtggtcatct ttggcttgca acattgccct ggatgctgtc      540

aagatggtac agtttgagga gaatggtcgg aaagagattg acataaaaaa atatgcaaga      600

gtggaaaaga tacctggagg catcattgaa gactcctgtg tcttgcgtgg agtcatgatt      660

aacaaggatg tgacccatcc acgtatgcgg cgctatatca agaaccctcg cattgtgctg      720

ctggattctt ctctggaata caagaaagga gaaagccaga ctgacattga gattacacga      780

gaggaggact tcacccgaat tctccagatg gaggaagagt acatccagca gctctgtgag      840

gacattatcc aactgaagcc cgatgtggtc atcactgaaa agggcatctc agatttagct      900

cagcactacc ttatgcgggc caatatcaca gccatccgca gagtccggaa gacagacaat      960

aatcgcattg ctagagcctg tggggcccgg atagtcagcc gaccagagga actgagagaa     1020

gatgatgttg gaacaggagc aggcctgttg gaaatcaaga aaattggaga tgaatacttt     1080

actttcatca ctgactgcaa agaccccaag gcctgcacca ttctcctccg gggggctagc     1140

aaagagattc tctcggaagt agaacgcaac ctccaggatg ccatgcaagt gtgtcgcaat     1200

gttctcctgg accctcagct ggtgccaggg ggtggggcct ccgagatggc tgtggcccat     1260

gccttgacag aaaaatccaa ggccatgact ggtgtggaac aatggccata cagggctgtt     1320

gcccaggccc tagaggtcat tcctcgtacc ctgatccaga actgtggggc cagcaccatc     1380

cgtctactta cctcccttcg ggccaagcac acccaggaga actgtgagac ctggggtgta     1440

aatggtgaga cgggtacttt ggtggacatg aaggaactgg gcatatggga gccattggct     1500

gtgaagctgc agacttataa gacagcagtg gagacggcag ttctgctact gcgaattgat     1560

gacatcgttt caggccacaa aaagaaaggc gatgaccaga gccggcaagg cggggctcct     1620

gatgctggcc aggagtga                                                   1638


<210>  5
<211>  2040
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5

<400>  5
atgataagtg ccagccgagc tgcagcagcc cgtctcgtgg gcgccgcagc ctcccggggc       60

cctacggccg cccgccacca ggatagctgg aatggcctta gtcatgaggc ttttagactt      120

gtttcaaggc gggattatgc atcagaagca atcaagggag cagttgttgg tattgatttg      180

ggtactacca actcctgcgt ggcagttatg gaaggtaaac aagcaaaggt gctggagaat      240

gccgaaggtg ccagaaccac cccttcagtt gtggccttta cagcagatgg tgagcgactt      300

gttggaatgc cggccaagcg acaggctgtc accaacccaa acaatacatt ttatgctacc      360

aagcgtctca ttggccggcg atatgatgat cctgaagtac agaaagacat taaaaatgtt      420

ccctttaaaa ttgtccgtgc ctccaatggt gatgcctggg ttgaggctca tgggaaattg      480

tattctccga gtcagattgg agcatttgtg ttgatgaaga tgaaagagac tgcagaaaat      540

tacttggggc acacagcaaa aaatgctgtg atcacagtcc cagcttattt caatgactcg      600

cagagacagg ccactaaaga tgctggccag atatctggac tgaatgtgct tcgggtgatt      660

aatgagccca cagctgctgc tcttgcctat ggtctagaca aatcagaaga caaagtcatt      720

gctgtatatg atttaggtgg tggaactttt gatatttcta tcctggaaat tcagaaagga      780

gtatttgagg tgaaatccac aaatggggat accttcttag gtggggaaga ctttgaccag      840

gccttgctac ggcacattgt gaaggagttc aagagagaga caggggttga tttgactaaa      900

gacaacatgg cacttcagag ggtacgggaa gctgctgaaa aggctaaatg tgaactctcc      960

tcatctgtgc agactgacat caatttgccc tatcttacaa tggattcttc tggacccaag     1020

catttgaata tgaagttgac ccgtgctcaa tttgaaggga ttgtcactga tctaatcaga     1080

aggactatcg ctccatgcca aaaagctatg caagatgcag aagtcagcaa gagtgacata     1140

ggagaagtga ttcttgtggg tggcatgact aggatgccca aggttcagca gactgtacag     1200

gatctttttg gcagagcccc aagtaaagct gtcaatcctg atgaggctgt ggccattgga     1260

gctgccattc agggaggtgt gttggccggc gatgtcacgg atgtgctgct ccttgatgtc     1320

actcccctgt ctctgggtat tgaaactcta ggaggtgtct ttaccaaact tattaatagg     1380

aataccacta ttccaaccaa gaagagccag gtattctcta ctgccgctga tggtcaaacg     1440

caagtggaaa ttaaagtgtg tcagggtgaa agagagatgg ctggagacaa caaactcctt     1500

ggacagttta ctttgattgg aattccacca gcccctcgtg gagttcctca gattgaagtt     1560

acatttgaca ttgatgccaa tgggatagta catgtttctg ctaaagataa aggcacagga     1620

cgtgagcagc agattgtaat ccagtcttct ggtggattaa gcaaagatga tattgaaaat     1680

atggttaaaa atgcagagaa atatgctgaa gaagaccggc gaaagaagga acgagttgaa     1740

gcagttaata tggctgaagg aatcattcac gacacagaaa ccaagatgga agaattcaag     1800

gaccaattac ctgctgatga gtgcaacaag ctgaaagaag agatttccaa aatgagggag     1860

ctcctggcta gaaaagacag cgaaacagga gaaaatatta gacaggcagc atcctctctt     1920

cagcaggcat cattgaagct gttcgaaatg gcatacaaaa agatggcatc tgagcgagaa     1980

ggctctggaa gttctggcac tggggaacaa aaggaagatc aaaaggagga aaaacagtaa     2040


<210>  6
<211>  2175
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6

<400>  6
atgcctgagg aagtgcacca tggagaggag gaggtggaga cttttgcctt tcaggcagaa       60

attgcccaac tcatgtccct catcatcaat accttctatt ccaacaagga gattttcctt      120

cgggagttga tctctaatgc ttctgatgcc ttggacaaga ttcgctatga gagcctgaca      180

gacccttcga agttggacag tggtaaagag ctgaaaattg acatcatccc caaccctcag      240

gaacgtaccc tgactttggt agacacaggc attggcatga ccaaagctga tctcataaat      300

aatttgggaa ccattgccaa gtctggtact aaagcattca tggaggctct tcaggctggt      360

gcagacatct ccatgattgg gcagtttggt gttggctttt attctgccta cttggtggca      420

gagaaagtgg ttgtgatcac aaagcacaac gatgatgaac agtatgcttg ggagtcttct      480

gctggaggtt ccttcactgt gcgtgctgac catggtgagc ccattggcag gggtaccaaa      540

gtgatcctcc atcttaaaga agatcagaca gagtacctag aagagaggcg ggtcaaagaa      600

gtagtgaaga agcattctca gttcataggc tatcccatca ccctttattt ggagaaggaa      660

cgagagaagg aaattagtga tgatgaggca gaggaagaga aaggtgagaa agaagaggaa      720

gataaagatg atgaagaaaa acccaagatc gaagatgtgg gttcagatga ggaggatgac      780

agcggtaagg ataagaagaa gaaaactaag aagatcaaag agaaatacat tgatcaggaa      840

gaactaaaca agaccaagcc tatttggacc agaaaccctg atgacatcac ccaagaggag      900

tatggagaat tctacaagag cctcactaat gactgggaag accacttggc agtcaagcac      960

ttttctgtag aaggtcagtt ggaattcagg gcattgctat ttattcctcg tcgggctccc     1020

tttgaccttt ttgagaacaa gaagaaaaag aacaacatca aactctatgt ccgccgtgtg     1080

ttcatcatgg acagctgtga tgagttgata ccagagtatc tcaattttat ccgtggtgtg     1140

gttgactctg aggatctgcc cctgaacatc tcccgagaaa tgctccagca gagcaaaatc     1200

ttgaaagtca ttcgcaaaaa cattgttaag aagtgccttg agctcttctc tgagctggca     1260

gaagacaagg agaattacaa gaaattctat gaggcattct ctaaaaatct caagcttgga     1320

atccacgaag actccactaa ccgccgccgc ctgtctgagc tgctgcgcta tcatacctcc     1380

cagtctggag atgagatgac atctctgtca gagtatgttt ctcgcatgaa ggagacacag     1440

aagtccatct attacatcac tggtgagagc aaagagcagg tggccaactc agcttttgtg     1500

gagcgagtgc ggaaacgggg cttcgaggtg gtatatatga ccgagcccat tgacgagtac     1560

tgtgtgcagc agctcaagga atttgatggg aagagcctgg tctcagttac caaggagggt     1620

ctggagctgc ctgaggatga ggaggagaag aagaagatgg aagagagcaa ggcaaagttt     1680

gagaacctct gcaagctcat gaaagaaatc ttagataaga aggttgagaa ggtgacaatc     1740

tccaatagac ttgtgtcttc accttgctgc attgtgacca gcacctacgg ctggacagcc     1800

aatatggagc ggatcatgaa agcccaggca cttcgggaca actccaccat gggctatatg     1860

atggccaaaa agcacctgga gatcaaccct gaccacccca ttgtggagac gctgcggcag     1920

aaggctgagg ccgacaagaa tgataaggca gttaaggacc tggtggtgct gctgtttgaa     1980

accgccctgc tatcttctgg cttttccctt gaggatcccc agacccactc caaccgcatc     2040

tatcgcatga tcaagctagg tctaggtatt gatgaagatg aagtggcagc agaggaaccc     2100

aatgctgcag ttcctgatga gatcccccct ctcgagggcg atgaggatgc gtctcgcatg     2160

gaagaagtcg attag                                                      2175


<210>  7
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7

<400>  7

Met Ala Ser Leu Ser Leu Ala Pro Val Asn Ile Phe Lys Ala Gly Ala 
1               5                   10                  15      


Asp Glu Glu Arg Ala Glu Thr Ala Arg Leu Thr Ser Phe Ile Gly Ala 
            20                  25                  30          


Ile Ala Ile Gly Asp Leu Val Lys Ser Thr Leu Gly Pro Lys Gly Met 
        35                  40                  45              


Asp Lys Ile Leu Leu Ser Ser Gly Arg Asp Ala Ser Leu Met Val Thr 
    50                  55                  60                  


Asn Asp Gly Ala Thr Ile Leu Lys Asn Ile Gly Val Asp Asn Pro Ala 
65                  70                  75                  80  


Ala Lys Val Leu Val Asp Met Ser Arg Val Gln Asp Asp Glu Val Gly 
                85                  90                  95      


Asp Gly Thr Thr Ser Val Thr Val Leu Ala Ala Glu Leu Leu Arg Glu 
            100                 105                 110         


Ala Glu Ser Leu Ile Ala Lys Lys Ile His Pro Gln Thr Ile Ile Ala 
        115                 120                 125             


Gly Trp Arg Glu Ala Thr Lys Ala Ala Arg Glu Ala Leu Leu Ser Ser 
    130                 135                 140                 


Ala Val Asp His Gly Ser Asp Glu Val Lys Phe Arg Gln Asp Leu Met 
145                 150                 155                 160 


Asn Ile Ala Gly Thr Thr Leu Ser Ser Lys Leu Leu Thr His His Lys 
                165                 170                 175     


Asp His Phe Thr Lys Leu Ala Val Glu Ala Val Leu Arg Leu Lys Gly 
            180                 185                 190         


Ser Gly Asn Leu Glu Ala Ile His Ile Ile Lys Lys Leu Gly Gly Ser 
        195                 200                 205             


Leu Ala Asp Ser Tyr Leu Asp Glu Gly Phe Leu Leu Asp Lys Lys Ile 
    210                 215                 220                 


Gly Val Asn Gln Pro Lys Arg Ile Glu Asn Ala Lys Ile Leu Ile Ala 
225                 230                 235                 240 


Asn Thr Gly Met Asp Thr Asp Lys Ile Lys Ile Phe Gly Ser Arg Val 
                245                 250                 255     


Arg Val Asp Ser Thr Ala Lys Val Ala Glu Ile Glu His Ala Glu Lys 
            260                 265                 270         


Glu Lys Met Lys Glu Lys Val Glu Arg Ile Leu Lys His Gly Ile Asn 
        275                 280                 285             


Cys Phe Ile Asn Arg Gln Leu Ile Tyr Asn Tyr Pro Glu Gln Leu Phe 
    290                 295                 300                 


Gly Ala Ala Gly Val Met Ala Ile Glu His Ala Asp Phe Ala Gly Val 
305                 310                 315                 320 


Glu Arg Leu Ala Leu Val Thr Gly Gly Glu Ile Ala Ser Thr Phe Asp 
                325                 330                 335     


His Pro Glu Leu Val Lys Leu Gly Ser Cys Lys Leu Ile Glu Glu Val 
            340                 345                 350         


Met Ile Gly Glu Asp Lys Leu Ile His Phe Ser Gly Val Ala Leu Gly 
        355                 360                 365             


Glu Ala Cys Thr Ile Val Leu Arg Gly Ala Thr Gln Gln Ile Leu Asp 
    370                 375                 380                 


Glu Ala Glu Arg Ser Leu His Asp Ala Leu Cys Val Leu Ala Gln Thr 
385                 390                 395                 400 


Val Lys Asp Ser Arg Thr Val Tyr Gly Gly Gly Cys Ser Glu Met Leu 
                405                 410                 415     


Met Ala His Ala Val Thr Gln Leu Ala Asn Arg Thr Pro Gly Lys Glu 
            420                 425                 430         


Ala Val Ala Met Glu Ser Tyr Ala Lys Ala Leu Arg Met Leu Pro Thr 
        435                 440                 445             


Ile Ile Ala Asp Asn Ala Gly Tyr Asp Ser Ala Asp Leu Val Ala Gln 
    450                 455                 460                 


Leu Arg Ala Ala His Ser Glu Gly Asn Thr Thr Ala Gly Leu Asp Met 
465                 470                 475                 480 


Arg Glu Gly Thr Ile Gly Asp Met Ala Ile Leu Gly Ile Thr Glu Ser 
                485                 490                 495     


Phe Gln Val Lys Arg Gln Val Leu Leu Ser Ala Ala Glu Ala Ala Glu 
            500                 505                 510         


Val Ile Leu Arg Val Asp Asn Ile Ile Lys Ala Ala Pro Arg Lys Arg 
        515                 520                 525             


Val Pro Asp His His Pro Cys 
    530                 535 


<210>  8
<211>  531
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8

<400>  8

Met Ala Ala Val Lys Thr Leu Asn Pro Lys Ala Glu Val Ala Arg Ala 
1               5                   10                  15      


Gln Ala Ala Leu Ala Val Asn Ile Ser Ala Ala Arg Gly Leu Gln Asp 
            20                  25                  30          


Val Leu Arg Thr Asn Leu Gly Pro Lys Gly Thr Met Lys Met Leu Val 
        35                  40                  45              


Ser Gly Ala Gly Asp Ile Lys Leu Thr Lys Asp Gly Asn Val Leu Leu 
    50                  55                  60                  


His Glu Met Gln Ile Gln His Pro Thr Ala Ser Leu Ile Ala Lys Val 
65                  70                  75                  80  


Ala Thr Ala Gln Asp Asp Ile Thr Gly Asp Gly Thr Thr Ser Asn Val 
                85                  90                  95      


Leu Ile Ile Gly Glu Leu Leu Lys Gln Ala Asp Leu Tyr Ile Ser Glu 
            100                 105                 110         


Gly Leu His Pro Arg Ile Ile Thr Glu Gly Phe Glu Ala Ala Lys Glu 
        115                 120                 125             


Lys Ala Leu Gln Phe Leu Glu Glu Val Lys Val Ser Arg Glu Met Asp 
    130                 135                 140                 


Arg Glu Thr Leu Ile Asp Val Ala Arg Thr Ser Leu Arg Thr Lys Val 
145                 150                 155                 160 


His Ala Glu Leu Ala Asp Val Leu Thr Glu Ala Val Val Asp Ser Ile 
                165                 170                 175     


Leu Ala Ile Lys Lys Gln Asp Glu Pro Ile Asp Leu Phe Met Ile Glu 
            180                 185                 190         


Ile Met Glu Met Lys His Lys Ser Glu Thr Asp Thr Ser Leu Ile Arg 
        195                 200                 205             


Gly Leu Val Leu Asp His Gly Ala Arg His Pro Asp Met Lys Lys Arg 
    210                 215                 220                 


Val Glu Asp Ala Tyr Ile Leu Thr Cys Asn Val Ser Leu Glu Tyr Glu 
225                 230                 235                 240 


Lys Thr Glu Val Asn Ser Gly Phe Phe Tyr Lys Ser Ala Glu Glu Arg 
                245                 250                 255     


Glu Lys Leu Val Lys Ala Glu Arg Lys Phe Ile Glu Asp Arg Val Lys 
            260                 265                 270         


Lys Ile Ile Glu Leu Lys Arg Lys Val Cys Gly Asp Ser Asp Lys Gly 
        275                 280                 285             


Phe Val Val Ile Asn Gln Lys Gly Ile Asp Pro Phe Ser Leu Asp Ala 
    290                 295                 300                 


Leu Ser Lys Glu Gly Ile Val Ala Leu Arg Arg Ala Lys Arg Arg Asn 
305                 310                 315                 320 


Met Glu Arg Leu Thr Leu Ala Cys Gly Gly Val Ala Leu Asn Ser Phe 
                325                 330                 335     


Asp Asp Leu Ser Pro Asp Cys Leu Gly His Ala Gly Leu Val Tyr Glu 
            340                 345                 350         


Tyr Thr Leu Gly Glu Glu Lys Phe Thr Phe Ile Glu Lys Cys Asn Asn 
        355                 360                 365             


Pro Arg Ser Val Thr Leu Leu Ile Lys Gly Pro Asn Lys His Thr Leu 
    370                 375                 380                 


Thr Gln Ile Lys Asp Ala Val Arg Asp Gly Leu Arg Ala Val Lys Asn 
385                 390                 395                 400 


Ala Ile Asp Asp Gly Cys Val Val Pro Gly Ala Gly Ala Val Glu Val 
                405                 410                 415     


Ala Met Ala Glu Ala Leu Ile Lys His Lys Pro Ser Val Lys Gly Arg 
            420                 425                 430         


Ala Gln Leu Gly Val Gln Ala Phe Ala Asp Ala Leu Leu Ile Ile Pro 
        435                 440                 445             


Lys Val Leu Ala Gln Asn Ser Gly Phe Asp Leu Gln Glu Thr Leu Val 
    450                 455                 460                 


Lys Ile Gln Ala Glu His Ser Glu Ser Gly Gln Leu Val Gly Val Asp 
465                 470                 475                 480 


Leu Asn Thr Gly Glu Pro Met Val Ala Ala Glu Val Gly Val Trp Asp 
                485                 490                 495     


Asn Tyr Cys Val Lys Lys Gln Leu Leu His Ser Cys Thr Val Ile Ala 
            500                 505                 510         


Thr Asn Ile Leu Leu Val Asp Glu Ile Met Arg Ala Gly Met Ser Ser 
        515                 520                 525             


Leu Lys Gly 
    530     


<210>  9
<211>  556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9

<400>  9

Met Glu Gly Pro Leu Ser Val Phe Gly Asp Arg Ser Thr Gly Glu Thr 
1               5                   10                  15      


Ile Arg Ser Gln Asn Val Met Ala Ala Ala Ser Ile Ala Asn Ile Val 
            20                  25                  30          


Lys Ser Ser Leu Gly Pro Val Gly Leu Asp Lys Met Leu Val Asp Asp 
        35                  40                  45              


Ile Gly Asp Val Thr Ile Thr Asn Asp Gly Ala Thr Ile Leu Lys Leu 
    50                  55                  60                  


Leu Glu Val Glu His Pro Ala Ala Lys Val Leu Cys Glu Leu Ala Asp 
65                  70                  75                  80  


Leu Gln Asp Lys Glu Val Gly Asp Gly Thr Thr Ser Val Val Ile Ile 
                85                  90                  95      


Ala Ala Glu Leu Leu Lys Asn Ala Asp Glu Leu Val Lys Gln Lys Ile 
            100                 105                 110         


His Pro Thr Ser Val Ile Ser Gly Tyr Arg Leu Ala Cys Lys Glu Ala 
        115                 120                 125             


Val Arg Tyr Ile Asn Glu Asn Leu Ile Val Asn Thr Asp Glu Leu Gly 
    130                 135                 140                 


Arg Asp Cys Leu Ile Asn Ala Ala Lys Thr Ser Met Ser Ser Lys Ile 
145                 150                 155                 160 


Ile Gly Ile Asn Gly Asp Phe Phe Ala Asn Met Val Val Asp Ala Val 
                165                 170                 175     


Leu Ala Ile Lys Tyr Thr Asp Ile Arg Gly Gln Pro Arg Tyr Pro Val 
            180                 185                 190         


Asn Ser Val Asn Ile Leu Lys Ala His Gly Arg Ser Gln Met Glu Ser 
        195                 200                 205             


Met Leu Ile Ser Gly Tyr Ala Leu Asn Cys Val Val Gly Ser Gln Gly 
    210                 215                 220                 


Met Pro Lys Arg Ile Val Asn Ala Lys Ile Ala Cys Leu Asp Phe Ser 
225                 230                 235                 240 


Leu Gln Lys Thr Lys Met Lys Leu Gly Val Gln Val Val Ile Thr Asp 
                245                 250                 255     


Pro Glu Lys Leu Asp Gln Ile Arg Gln Arg Glu Ser Asp Ile Thr Lys 
            260                 265                 270         


Glu Arg Ile Gln Lys Ile Leu Ala Thr Gly Ala Asn Val Ile Leu Thr 
        275                 280                 285             


Thr Gly Gly Ile Asp Asp Met Cys Leu Lys Tyr Phe Val Glu Ala Gly 
    290                 295                 300                 


Ala Met Ala Val Arg Arg Val Leu Lys Arg Asp Leu Lys Arg Ile Ala 
305                 310                 315                 320 


Lys Ala Ser Gly Ala Thr Ile Leu Ser Thr Leu Ala Asn Leu Glu Gly 
                325                 330                 335     


Glu Glu Thr Phe Glu Ala Ala Met Leu Gly Gln Ala Glu Glu Val Val 
            340                 345                 350         


Gln Glu Arg Ile Cys Asp Asp Glu Leu Ile Leu Ile Lys Asn Thr Lys 
        355                 360                 365             


Ala Arg Thr Ser Ala Ser Ile Ile Leu Arg Gly Ala Asn Asp Phe Met 
    370                 375                 380                 


Cys Asp Glu Met Glu Arg Ser Leu His Asp Ala Leu Cys Val Val Lys 
385                 390                 395                 400 


Arg Val Leu Glu Ser Lys Ser Val Val Pro Gly Gly Gly Ala Val Glu 
                405                 410                 415     


Ala Ala Leu Ser Ile Tyr Leu Glu Asn Tyr Ala Thr Ser Met Gly Ser 
            420                 425                 430         


Arg Glu Gln Leu Ala Ile Ala Glu Phe Ala Arg Ser Leu Leu Val Ile 
        435                 440                 445             


Pro Asn Thr Leu Ala Val Asn Ala Ala Gln Asp Ser Thr Asp Leu Val 
    450                 455                 460                 


Ala Lys Leu Arg Ala Phe His Asn Glu Ala Gln Val Asn Pro Glu Arg 
465                 470                 475                 480 


Lys Asn Leu Lys Trp Ile Gly Leu Asp Leu Ser Asn Gly Lys Pro Arg 
                485                 490                 495     


Asp Asn Lys Gln Ala Gly Val Phe Glu Pro Thr Ile Val Lys Val Lys 
            500                 505                 510         


Ser Leu Lys Phe Ala Thr Glu Ala Ala Ile Thr Ile Leu Arg Ile Asp 
        515                 520                 525             


Asp Leu Ile Lys Leu His Pro Glu Ser Lys Asp Asp Lys His Gly Ser 
    530                 535                 540                 


Tyr Glu Asp Ala Val His Ser Gly Ala Leu Asn Asp 
545                 550                 555     


<210>  10
<211>  545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10

<400>  10

Met Met Gly His Arg Pro Val Leu Val Leu Ser Gln Asn Thr Lys Arg 
1               5                   10                  15      


Glu Ser Gly Arg Lys Val Gln Ser Gly Asn Ile Asn Ala Ala Lys Thr 
            20                  25                  30          


Ile Ala Asp Ile Ile Arg Thr Cys Leu Gly Pro Lys Ser Met Met Lys 
        35                  40                  45              


Met Leu Leu Asp Pro Met Gly Gly Ile Val Met Thr Asn Asp Gly Asn 
    50                  55                  60                  


Ala Ile Leu Arg Glu Ile Gln Val Gln His Pro Ala Ala Lys Ser Met 
65                  70                  75                  80  


Ile Glu Ile Ser Arg Thr Gln Asp Glu Glu Val Gly Asp Gly Thr Thr 
                85                  90                  95      


Ser Val Ile Ile Leu Ala Gly Glu Met Leu Ser Val Ala Glu His Phe 
            100                 105                 110         


Leu Glu Gln Gln Met His Pro Thr Val Val Ile Ser Ala Tyr Arg Lys 
        115                 120                 125             


Ala Leu Asp Asp Met Ile Ser Thr Leu Lys Lys Ile Ser Ile Pro Val 
    130                 135                 140                 


Asp Ile Ser Asp Ser Asp Met Met Leu Asn Ile Ile Asn Ser Ser Ile 
145                 150                 155                 160 


Thr Thr Lys Ala Ile Ser Arg Trp Ser Ser Leu Ala Cys Asn Ile Ala 
                165                 170                 175     


Leu Asp Ala Val Lys Met Val Gln Phe Glu Glu Asn Gly Arg Lys Glu 
            180                 185                 190         


Ile Asp Ile Lys Lys Tyr Ala Arg Val Glu Lys Ile Pro Gly Gly Ile 
        195                 200                 205             


Ile Glu Asp Ser Cys Val Leu Arg Gly Val Met Ile Asn Lys Asp Val 
    210                 215                 220                 


Thr His Pro Arg Met Arg Arg Tyr Ile Lys Asn Pro Arg Ile Val Leu 
225                 230                 235                 240 


Leu Asp Ser Ser Leu Glu Tyr Lys Lys Gly Glu Ser Gln Thr Asp Ile 
                245                 250                 255     


Glu Ile Thr Arg Glu Glu Asp Phe Thr Arg Ile Leu Gln Met Glu Glu 
            260                 265                 270         


Glu Tyr Ile Gln Gln Leu Cys Glu Asp Ile Ile Gln Leu Lys Pro Asp 
        275                 280                 285             


Val Val Ile Thr Glu Lys Gly Ile Ser Asp Leu Ala Gln His Tyr Leu 
    290                 295                 300                 


Met Arg Ala Asn Ile Thr Ala Ile Arg Arg Val Arg Lys Thr Asp Asn 
305                 310                 315                 320 


Asn Arg Ile Ala Arg Ala Cys Gly Ala Arg Ile Val Ser Arg Pro Glu 
                325                 330                 335     


Glu Leu Arg Glu Asp Asp Val Gly Thr Gly Ala Gly Leu Leu Glu Ile 
            340                 345                 350         


Lys Lys Ile Gly Asp Glu Tyr Phe Thr Phe Ile Thr Asp Cys Lys Asp 
        355                 360                 365             


Pro Lys Ala Cys Thr Ile Leu Leu Arg Gly Ala Ser Lys Glu Ile Leu 
    370                 375                 380                 


Ser Glu Val Glu Arg Asn Leu Gln Asp Ala Met Gln Val Cys Arg Asn 
385                 390                 395                 400 


Val Leu Leu Asp Pro Gln Leu Val Pro Gly Gly Gly Ala Ser Glu Met 
                405                 410                 415     


Ala Val Ala His Ala Leu Thr Glu Lys Ser Lys Ala Met Thr Gly Val 
            420                 425                 430         


Glu Gln Trp Pro Tyr Arg Ala Val Ala Gln Ala Leu Glu Val Ile Pro 
        435                 440                 445             


Arg Thr Leu Ile Gln Asn Cys Gly Ala Ser Thr Ile Arg Leu Leu Thr 
    450                 455                 460                 


Ser Leu Arg Ala Lys His Thr Gln Glu Asn Cys Glu Thr Trp Gly Val 
465                 470                 475                 480 


Asn Gly Glu Thr Gly Thr Leu Val Asp Met Lys Glu Leu Gly Ile Trp 
                485                 490                 495     


Glu Pro Leu Ala Val Lys Leu Gln Thr Tyr Lys Thr Ala Val Glu Thr 
            500                 505                 510         


Ala Val Leu Leu Leu Arg Ile Asp Asp Ile Val Ser Gly His Lys Lys 
        515                 520                 525             


Lys Gly Asp Asp Gln Ser Arg Gln Gly Gly Ala Pro Asp Ala Gly Gln 
    530                 535                 540                 


Glu 
545 


<210>  11
<211>  679
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11

<400>  11

Met Ile Ser Ala Ser Arg Ala Ala Ala Ala Arg Leu Val Gly Ala Ala 
1               5                   10                  15      


Ala Ser Arg Gly Pro Thr Ala Ala Arg His Gln Asp Ser Trp Asn Gly 
            20                  25                  30          


Leu Ser His Glu Ala Phe Arg Leu Val Ser Arg Arg Asp Tyr Ala Ser 
        35                  40                  45              


Glu Ala Ile Lys Gly Ala Val Val Gly Ile Asp Leu Gly Thr Thr Asn 
    50                  55                  60                  


Ser Cys Val Ala Val Met Glu Gly Lys Gln Ala Lys Val Leu Glu Asn 
65                  70                  75                  80  


Ala Glu Gly Ala Arg Thr Thr Pro Ser Val Val Ala Phe Thr Ala Asp 
                85                  90                  95      


Gly Glu Arg Leu Val Gly Met Pro Ala Lys Arg Gln Ala Val Thr Asn 
            100                 105                 110         


Pro Asn Asn Thr Phe Tyr Ala Thr Lys Arg Leu Ile Gly Arg Arg Tyr 
        115                 120                 125             


Asp Asp Pro Glu Val Gln Lys Asp Ile Lys Asn Val Pro Phe Lys Ile 
    130                 135                 140                 


Val Arg Ala Ser Asn Gly Asp Ala Trp Val Glu Ala His Gly Lys Leu 
145                 150                 155                 160 


Tyr Ser Pro Ser Gln Ile Gly Ala Phe Val Leu Met Lys Met Lys Glu 
                165                 170                 175     


Thr Ala Glu Asn Tyr Leu Gly His Thr Ala Lys Asn Ala Val Ile Thr 
            180                 185                 190         


Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp Ala 
        195                 200                 205             


Gly Gln Ile Ser Gly Leu Asn Val Leu Arg Val Ile Asn Glu Pro Thr 
    210                 215                 220                 


Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Ser Glu Asp Lys Val Ile 
225                 230                 235                 240 


Ala Val Tyr Asp Leu Gly Gly Gly Thr Phe Asp Ile Ser Ile Leu Glu 
                245                 250                 255     


Ile Gln Lys Gly Val Phe Glu Val Lys Ser Thr Asn Gly Asp Thr Phe 
            260                 265                 270         


Leu Gly Gly Glu Asp Phe Asp Gln Ala Leu Leu Arg His Ile Val Lys 
        275                 280                 285             


Glu Phe Lys Arg Glu Thr Gly Val Asp Leu Thr Lys Asp Asn Met Ala 
    290                 295                 300                 


Leu Gln Arg Val Arg Glu Ala Ala Glu Lys Ala Lys Cys Glu Leu Ser 
305                 310                 315                 320 


Ser Ser Val Gln Thr Asp Ile Asn Leu Pro Tyr Leu Thr Met Asp Ser 
                325                 330                 335     


Ser Gly Pro Lys His Leu Asn Met Lys Leu Thr Arg Ala Gln Phe Glu 
            340                 345                 350         


Gly Ile Val Thr Asp Leu Ile Arg Arg Thr Ile Ala Pro Cys Gln Lys 
        355                 360                 365             


Ala Met Gln Asp Ala Glu Val Ser Lys Ser Asp Ile Gly Glu Val Ile 
    370                 375                 380                 


Leu Val Gly Gly Met Thr Arg Met Pro Lys Val Gln Gln Thr Val Gln 
385                 390                 395                 400 


Asp Leu Phe Gly Arg Ala Pro Ser Lys Ala Val Asn Pro Asp Glu Ala 
                405                 410                 415     


Val Ala Ile Gly Ala Ala Ile Gln Gly Gly Val Leu Ala Gly Asp Val 
            420                 425                 430         


Thr Asp Val Leu Leu Leu Asp Val Thr Pro Leu Ser Leu Gly Ile Glu 
        435                 440                 445             


Thr Leu Gly Gly Val Phe Thr Lys Leu Ile Asn Arg Asn Thr Thr Ile 
    450                 455                 460                 


Pro Thr Lys Lys Ser Gln Val Phe Ser Thr Ala Ala Asp Gly Gln Thr 
465                 470                 475                 480 


Gln Val Glu Ile Lys Val Cys Gln Gly Glu Arg Glu Met Ala Gly Asp 
                485                 490                 495     


Asn Lys Leu Leu Gly Gln Phe Thr Leu Ile Gly Ile Pro Pro Ala Pro 
            500                 505                 510         


Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly 
        515                 520                 525             


Ile Val His Val Ser Ala Lys Asp Lys Gly Thr Gly Arg Glu Gln Gln 
    530                 535                 540                 


Ile Val Ile Gln Ser Ser Gly Gly Leu Ser Lys Asp Asp Ile Glu Asn 
545                 550                 555                 560 


Met Val Lys Asn Ala Glu Lys Tyr Ala Glu Glu Asp Arg Arg Lys Lys 
                565                 570                 575     


Glu Arg Val Glu Ala Val Asn Met Ala Glu Gly Ile Ile His Asp Thr 
            580                 585                 590         


Glu Thr Lys Met Glu Glu Phe Lys Asp Gln Leu Pro Ala Asp Glu Cys 
        595                 600                 605             


Asn Lys Leu Lys Glu Glu Ile Ser Lys Met Arg Glu Leu Leu Ala Arg 
    610                 615                 620                 


Lys Asp Ser Glu Thr Gly Glu Asn Ile Arg Gln Ala Ala Ser Ser Leu 
625                 630                 635                 640 


Gln Gln Ala Ser Leu Lys Leu Phe Glu Met Ala Tyr Lys Lys Met Ala 
                645                 650                 655     


Ser Glu Arg Glu Gly Ser Gly Ser Ser Gly Thr Gly Glu Gln Lys Glu 
            660                 665                 670         


Asp Gln Lys Glu Glu Lys Gln 
        675                 


<210>  12
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12

<400>  12

Met Pro Glu Glu Val His His Gly Glu Glu Glu Val Glu Thr Phe Ala 
1               5                   10                  15      


Phe Gln Ala Glu Ile Ala Gln Leu Met Ser Leu Ile Ile Asn Thr Phe 
            20                  25                  30          


Tyr Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser 
        35                  40                  45              


Asp Ala Leu Asp Lys Ile Arg Tyr Glu Ser Leu Thr Asp Pro Ser Lys 
    50                  55                  60                  


Leu Asp Ser Gly Lys Glu Leu Lys Ile Asp Ile Ile Pro Asn Pro Gln 
65                  70                  75                  80  


Glu Arg Thr Leu Thr Leu Val Asp Thr Gly Ile Gly Met Thr Lys Ala 
                85                  90                  95      


Asp Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Lys Ala 
            100                 105                 110         


Phe Met Glu Ala Leu Gln Ala Gly Ala Asp Ile Ser Met Ile Gly Gln 
        115                 120                 125             


Phe Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val Ala Glu Lys Val Val 
    130                 135                 140                 


Val Ile Thr Lys His Asn Asp Asp Glu Gln Tyr Ala Trp Glu Ser Ser 
145                 150                 155                 160 


Ala Gly Gly Ser Phe Thr Val Arg Ala Asp His Gly Glu Pro Ile Gly 
                165                 170                 175     


Arg Gly Thr Lys Val Ile Leu His Leu Lys Glu Asp Gln Thr Glu Tyr 
            180                 185                 190         


Leu Glu Glu Arg Arg Val Lys Glu Val Val Lys Lys His Ser Gln Phe 
        195                 200                 205             


Ile Gly Tyr Pro Ile Thr Leu Tyr Leu Glu Lys Glu Arg Glu Lys Glu 
    210                 215                 220                 


Ile Ser Asp Asp Glu Ala Glu Glu Glu Lys Gly Glu Lys Glu Glu Glu 
225                 230                 235                 240 


Asp Lys Asp Asp Glu Glu Lys Pro Lys Ile Glu Asp Val Gly Ser Asp 
                245                 250                 255     


Glu Glu Asp Asp Ser Gly Lys Asp Lys Lys Lys Lys Thr Lys Lys Ile 
            260                 265                 270         


Lys Glu Lys Tyr Ile Asp Gln Glu Glu Leu Asn Lys Thr Lys Pro Ile 
        275                 280                 285             


Trp Thr Arg Asn Pro Asp Asp Ile Thr Gln Glu Glu Tyr Gly Glu Phe 
    290                 295                 300                 


Tyr Lys Ser Leu Thr Asn Asp Trp Glu Asp His Leu Ala Val Lys His 
305                 310                 315                 320 


Phe Ser Val Glu Gly Gln Leu Glu Phe Arg Ala Leu Leu Phe Ile Pro 
                325                 330                 335     


Arg Arg Ala Pro Phe Asp Leu Phe Glu Asn Lys Lys Lys Lys Asn Asn 
            340                 345                 350         


Ile Lys Leu Tyr Val Arg Arg Val Phe Ile Met Asp Ser Cys Asp Glu 
        355                 360                 365             


Leu Ile Pro Glu Tyr Leu Asn Phe Ile Arg Gly Val Val Asp Ser Glu 
    370                 375                 380                 


Asp Leu Pro Leu Asn Ile Ser Arg Glu Met Leu Gln Gln Ser Lys Ile 
385                 390                 395                 400 


Leu Lys Val Ile Arg Lys Asn Ile Val Lys Lys Cys Leu Glu Leu Phe 
                405                 410                 415     


Ser Glu Leu Ala Glu Asp Lys Glu Asn Tyr Lys Lys Phe Tyr Glu Ala 
            420                 425                 430         


Phe Ser Lys Asn Leu Lys Leu Gly Ile His Glu Asp Ser Thr Asn Arg 
        435                 440                 445             


Arg Arg Leu Ser Glu Leu Leu Arg Tyr His Thr Ser Gln Ser Gly Asp 
    450                 455                 460                 


Glu Met Thr Ser Leu Ser Glu Tyr Val Ser Arg Met Lys Glu Thr Gln 
465                 470                 475                 480 


Lys Ser Ile Tyr Tyr Ile Thr Gly Glu Ser Lys Glu Gln Val Ala Asn 
                485                 490                 495     


Ser Ala Phe Val Glu Arg Val Arg Lys Arg Gly Phe Glu Val Val Tyr 
            500                 505                 510         


Met Thr Glu Pro Ile Asp Glu Tyr Cys Val Gln Gln Leu Lys Glu Phe 
        515                 520                 525             


Asp Gly Lys Ser Leu Val Ser Val Thr Lys Glu Gly Leu Glu Leu Pro 
    530                 535                 540                 


Glu Asp Glu Glu Glu Lys Lys Lys Met Glu Glu Ser Lys Ala Lys Phe 
545                 550                 555                 560 


Glu Asn Leu Cys Lys Leu Met Lys Glu Ile Leu Asp Lys Lys Val Glu 
                565                 570                 575     


Lys Val Thr Ile Ser Asn Arg Leu Val Ser Ser Pro Cys Cys Ile Val 
            580                 585                 590         


Thr Ser Thr Tyr Gly Trp Thr Ala Asn Met Glu Arg Ile Met Lys Ala 
        595                 600                 605             


Gln Ala Leu Arg Asp Asn Ser Thr Met Gly Tyr Met Met Ala Lys Lys 
    610                 615                 620                 


His Leu Glu Ile Asn Pro Asp His Pro Ile Val Glu Thr Leu Arg Gln 
625                 630                 635                 640 


Lys Ala Glu Ala Asp Lys Asn Asp Lys Ala Val Lys Asp Leu Val Val 
                645                 650                 655     


Leu Leu Phe Glu Thr Ala Leu Leu Ser Ser Gly Phe Ser Leu Glu Asp 
            660                 665                 670         


Pro Gln Thr His Ser Asn Arg Ile Tyr Arg Met Ile Lys Leu Gly Leu 
        675                 680                 685             


Gly Ile Asp Glu Asp Glu Val Ala Ala Glu Glu Pro Asn Ala Ala Val 
    690                 695                 700                 


Pro Asp Glu Ile Pro Pro Leu Glu Gly Asp Glu Asp Ala Ser Arg Met 
705                 710                 715                 720 


Glu Glu Val Asp 
                


<210>  13
<211>  334
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13

<400>  13

Met Gly Phe Leu Leu Asp Lys Lys Ile Gly Val Asn Gln Pro Lys Arg 
1               5                   10                  15      


Ile Glu Asn Ala Lys Ile Leu Ile Ala Asn Thr Gly Met Asp Thr Asp 
            20                  25                  30          


Lys Ile Lys Ile Phe Gly Ser Arg Val Arg Val Asp Ser Thr Ala Lys 
        35                  40                  45              


Val Ala Glu Ile Glu His Ala Glu Lys Glu Lys Met Lys Glu Lys Val 
    50                  55                  60                  


Glu Arg Ile Leu Lys His Gly Ile Asn Cys Phe Ile Asn Arg Gln Leu 
65                  70                  75                  80  


Ile Tyr Asn Tyr Pro Glu Gln Leu Phe Gly Ala Ala Gly Val Met Ala 
                85                  90                  95      


Ile Glu His Ala Asp Phe Ala Gly Val Glu Arg Leu Ala Leu Val Thr 
            100                 105                 110         


Gly Gly Glu Ile Ala Ser Thr Phe Asp His Pro Glu Leu Val Lys Leu 
        115                 120                 125             


Gly Ser Cys Lys Leu Ile Glu Glu Val Met Ile Gly Glu Asp Lys Leu 
    130                 135                 140                 


Ile His Phe Ser Gly Val Ala Leu Gly Gly Lys Pro Ile Pro Asn Pro 
145                 150                 155                 160 


Leu Leu Gly Leu Asp Ser Thr Glu Ala Cys Thr Ile Val Leu Arg Gly 
                165                 170                 175     


Ala Thr Gln Gln Ile Leu Asp Glu Ala Glu Arg Ser Leu His Asp Ala 
            180                 185                 190         


Leu Cys Val Leu Ala Gln Thr Val Lys Asp Ser Arg Thr Val Tyr Gly 
        195                 200                 205             


Gly Gly Cys Ser Glu Met Leu Met Ala His Ala Val Thr Gln Leu Ala 
    210                 215                 220                 


Asn Arg Thr Pro Gly Lys Glu Ala Val Ala Met Glu Ser Tyr Ala Lys 
225                 230                 235                 240 


Ala Leu Arg Met Leu Pro Thr Ile Ile Ala Asp Asn Ala Gly Tyr Asp 
                245                 250                 255     


Ser Ala Asp Leu Val Ala Gln Leu Arg Ala Ala His Ser Glu Gly Asn 
            260                 265                 270         


Thr Thr Ala Gly Leu Asp Met Arg Glu Gly Thr Ile Gly Asp Met Ala 
        275                 280                 285             


Ile Leu Gly Ile Thr Glu Ser Phe Gln Val Lys Arg Gln Val Leu Leu 
    290                 295                 300                 


Ser Ala Ala Glu Ala Ala Glu Val Ile Leu Arg Val Asp Asn Ile Ile 
305                 310                 315                 320 


Lys Ala Ala Pro Arg Lys Arg Val Pro Asp His His Pro Cys 
                325                 330                 


<210>  14
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14

<400>  14

Met Gly Phe Leu Leu Asp Lys Lys Ile Gly Val Asn Gln Pro Lys Arg 
1               5                   10                  15      


Ile Glu Asn Ala Lys Ile Leu Ile Ala Asn Thr Gly Met Asp Thr Asp 
            20                  25                  30          


Lys Ile Lys Ile Phe Gly Ser Arg Val Arg Val Asp Ser Thr Ala Lys 
        35                  40                  45              


Val Ala Glu Ile Glu His Ala Glu Lys Glu Lys Met Lys Glu Lys Val 
    50                  55                  60                  


Glu Arg Ile Leu Lys His Gly Ile Asn Cys Phe Ile Asn Arg Gln Leu 
65                  70                  75                  80  


Ile Tyr Asn Tyr Pro Glu Gln Leu Phe Gly Ala Ala Gly Val Met Ala 
                85                  90                  95      


Ile Glu His Ala Asp Phe Ala Gly Val Glu Arg Leu Ala Leu Val Thr 
            100                 105                 110         


Gly Gly Glu Ile Ala Ser Thr Phe Asp His Pro Glu Leu Val Lys Leu 
        115                 120                 125             


Gly Ser Cys Lys Leu Ile Glu Glu Val Met Ile Gly Glu Asp Lys Leu 
    130                 135                 140                 


Ile His Phe Ser Gly Val Ala Leu Gly Gly Ser Gly Gly Ile Leu Gly 
145                 150                 155                 160 


Ile Thr Glu Ser Phe Gln Val Lys Arg Gln Val Leu Leu Ser Ala Ala 
                165                 170                 175     


Glu Ala Ala Glu Val Ile Leu Arg Val Asp Asn 
            180                 185         


<210>  15
<211>  1005
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  15

<400>  15
atgggcttcc tgttggataa aaaaattgga gtaaatcaac caaaacgaat tgaaaatgct       60

aaaattctta ttgcaaatac tggtatggat acagacaaaa taaagatatt tggttcccgg      120

gtaagagttg actctacagc aaaggttgca gaaatagaac atgcggaaaa ggaaaaaatg      180

aaggagaaag ttgaacgtat tcttaagcat ggaataaatt gctttattaa caggcaatta      240

atttataatt atcctgaaca gctctttggt gctgctggtg tcatggctat tgagcatgca      300

gattttgcag gtgtggaacg cctagctctt gtcacaggtg gtgaaattgc ctctaccttt      360

gatcacccag aactggtgaa gcttggaagt tgcaaactta tcgaggaagt catgattgga      420

gaagacaaac tcattcactt ttctggggtt gcccttggtg gtaagcctat ccctaaccct      480

ctcctcggtc tcgattctac ggaggcttgt accattgttt tgcgtggtgc cactcaacaa      540

attttagatg aagcagaaag atcattgcat gatgctcttt gtgttcttgc gcaaactgta      600

aaggactcta gaacagttta tggaggaggc tgttctgaga tgttgatggc tcatgctgtg      660

acacagcttg ccaatagaac accaggcaaa gaagctgttg caatggagtc ttatgctaaa      720

gcactgagaa tgttgccaac catcatagct gacaatgcag gctatgacag tgcagacctg      780

gtggcacagc tcagggctgc tcacagtgaa ggcaatacca ctgctggatt ggatatgagg      840

gaaggcacca ttggagatat ggctatcctg ggtataacag aaagttttca agtgaagcga      900

caggttcttc tgagtgcagc tgaagcagca gaggtgattc tgcgtgtgga caacatcatc      960

aaagcggcac ccaggaaacg tgtccctgat caccacccct gttag                     1005


<210>  16
<211>  564
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  16

<400>  16
atgggcttcc tgttggataa aaaaattgga gtaaatcaac caaaacgaat tgaaaatgct       60

aaaattctta ttgcaaatac tggtatggat acagacaaaa taaagatatt tggttcccgg      120

gtaagagttg actctacagc aaaggttgca gaaatagaac atgcggaaaa ggaaaaaatg      180

aaggagaaag ttgaacgtat tcttaagcat ggaataaatt gctttattaa caggcaatta      240

atttataatt atcctgaaca gctctttggt gctgctggtg tcatggctat tgagcatgca      300

gattttgcag gtgtggaacg cctagctctt gtcacaggtg gtgaaattgc ctctaccttt      360

gatcacccag aactggtgaa gcttggaagt tgcaaactta tcgaggaagt catgattgga      420

gaagacaaac tcattcactt ttctggggtt gcccttggtg gaagtggtgg aatcctgggt      480

ataacagaaa gttttcaagt gaagcgacag gttcttctga gtgcagctga agcagcagag      540

gtgattctgc gtgtggacaa ctga                                             564


<210>  17
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17

<400>  17

Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


