                         SEQUENCE LISTING

<110>  ڻѧоԺ
 
<120>  øBCH2X;

<130>  IEC210366PCT

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCH248

<400>  1

Met Asn Tyr Lys Glu Ile Leu Ser Gln Glu Gln Tyr Lys Ile Phe Asp 
1               5                   10                  15      


Ser Ile Ile Gln Asp Ile Gln Ile Asn His Asp Glu Gly Cys Phe Gly 
            20                  25                  30          


Glu Asn Ile Ile Met Ile Thr Gly Gln Ala Gly Thr Gly Lys Ser Phe 
        35                  40                  45              


Leu Ser Ala Ala Leu Ile Lys Tyr Leu Glu Asp Thr Lys Ile Ser Thr 
    50                  55                  60                  


Arg Pro Ile Lys Cys Thr Ala Leu Thr His Lys Ala Ala Ala Glu Leu 
65                  70                  75                  80  


Gln Lys Lys Leu Lys Glu Val Asn Ser Ser Leu Lys Thr Gly Thr Ile 
                85                  90                  95      


His Ser Tyr Leu Lys Ile Lys Ala Ser Ile Asn Tyr Gln Thr Gly Lys 
            100                 105                 110         


Glu Glu Phe Lys Val Glu Arg Asn Ala Lys Ile Val Pro Ser Ser Val 
        115                 120                 125             


Leu Phe Ile Asp Glu Cys Ser Met Ile Asp Ala Asp Leu Phe Lys Ile 
    130                 135                 140                 


Ile Arg Glu His Met Glu Leu Tyr Glu Thr Val Ile Met Ile Gly Asp 
145                 150                 155                 160 


Glu Tyr Gln Thr Pro Pro Val Asn Arg Gly Asp Phe Asn Leu Phe Thr 
                165                 170                 175     


His Pro Ser Ile Lys Thr His Lys Leu Glu Asn Ile Val Arg Gln Ala 
            180                 185                 190         


Ala Gly Asn Pro Ile Ile Gln Leu Ser Asn Glu Ile Val Gln Lys Ile 
        195                 200                 205             


Lys Thr Lys Asp Phe Asn Val Asn Phe Cys Asn Asp Leu Ile Leu Lys 
    210                 215                 220                 


Ser Ala Cys Glu Glu Ile Val Gln Cys Ser Pro Asn Glu Phe Ile Val 
225                 230                 235                 240 


Asn Tyr Ile Asn Tyr Thr Lys Asn Asp Val Asn Lys Pro Leu Lys Gly 
                245                 250                 255     


Ser Arg Phe Thr Gln Ala Leu Ile Thr Thr Phe Thr Asn Asp Arg Val 
            260                 265                 270         


Asn Lys Tyr Asn Thr Ile Ala Lys Thr Ile Tyr Lys Asn Thr Arg Asn 
        275                 280                 285             


Ile Asn Phe Ile Asp Gln Gly Asp Ile Val Val Thr Gln Glu Pro Ala 
    290                 295                 300                 


Phe Asn Gln Tyr Thr Lys Asp Ile Glu Leu Ser Gly Asn Ser Glu Phe 
305                 310                 315                 320 


Phe Val Gln Lys Leu Thr Lys Glu Thr Phe Glu Asp Ile Pro Cys Leu 
                325                 330                 335     


Ile Leu Glu Asn Asp Asp His Pro Tyr Phe Phe Leu Arg Val Ile Asp 
            340                 345                 350         


Glu His Asp Phe Leu Ala Leu Gln Met Tyr Asn Lys Lys Leu Gln Tyr 
        355                 360                 365             


Tyr Lys Asn Asn Ala Leu Leu Ala Ser Gly Lys Gln Lys Phe Lys Ala 
    370                 375                 380                 


Trp Gln Ala Phe Tyr Asn Phe Lys Arg Ser Phe Val Thr Ile Lys Gln 
385                 390                 395                 400 


Ile Phe Ala Cys Thr Thr His Lys Ala Gln Gly Thr Thr Val Asn Arg 
                405                 410                 415     


Ile Tyr Val Asp Met Asn Asn Met Pro Trp Glu Tyr Asp Ile Asp Leu 
            420                 425                 430         


Ala Tyr Arg Leu Thr Tyr Val Ala Cys Thr Arg Ser Thr Asp Lys Leu 
        435                 440                 445             


Ile Val Thr Leu 
    450         


<210>  2
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCH256

<400>  2

Met Ile Asp Thr Thr Leu Asn Asn Glu Gln Gly Lys Ile Ala Lys Gln 
1               5                   10                  15      


Ile Ile Asp Asn Ile His Tyr Asp Ile Ser Gln Gly Gly Phe Asp Asn 
            20                  25                  30          


Asn Thr Tyr Leu Ile Thr Gly Arg Ala Gly Thr Gly Lys Ser Tyr Leu 
        35                  40                  45              


Ala Gly Ser Ile Ile Asp Tyr Phe Gln Lys Asn Asn Phe Lys Ile Gln 
    50                  55                  60                  


Cys Thr Ala Leu Thr His Lys Ala Leu Lys Glu Ile Arg Asp Lys Leu 
65                  70                  75                  80  


Leu Ala Gln Gly Ile Asn Met Asp Asp Leu Asn Gly Ile Ser Thr Val 
                85                  90                  95      


His Ser Tyr Phe Gly Ile Lys Pro Val Ile Asn Thr Lys Thr Gly Glu 
            100                 105                 110         


Glu Glu Phe Ser Val Asn Gln Phe Lys Lys Pro Arg Lys Cys Asp Ile 
        115                 120                 125             


Leu Phe Ile Asp Glu Val Ser Met Met Asp Leu Ser Leu Tyr Lys Leu 
    130                 135                 140                 


Val Lys Ser Gln Gln His Leu Tyr Lys Thr Thr Val Leu Ile Gly Asp 
145                 150                 155                 160 


Glu Tyr Gln Ile Ser Pro Val Asn Lys His Asp Lys Thr Ile Phe Asp 
                165                 170                 175     


Phe Lys Ser Ile Lys Lys Tyr Glu Leu Asn Asn Ile Val Arg Gln Ala 
            180                 185                 190         


Glu Gly Asn Lys Ile Ile Glu Leu Ala Ser Glu Ile Val Gln Lys Ile 
        195                 200                 205             


Lys Asn Lys Asp Tyr Lys Asp Lys Ser Phe Cys Ile Lys Lys Val Lys 
    210                 215                 220                 


Glu Tyr Ser Lys Val Ser Asp Asn Ile Asp Ile Val Phe Asn Ser Asn 
225                 230                 235                 240 


Asp Phe Ile Lys Lys Tyr Trp Glu Phe Thr Asn Glu Asp Ala Gln Lys 
                245                 250                 255     


Pro Tyr Phe Lys Ser Lys Phe Ser Gln Ala Leu Ile Thr Thr Phe Thr 
            260                 265                 270         


Asn Lys Val Val Asp Asn Tyr Asn Tyr Ile Ala Lys Cys Ile Met Lys 
        275                 280                 285             


Gln Thr Arg Glu Ile Asn Tyr Ile Asp Val Gly Asp Val Ile Val Leu 
    290                 295                 300                 


Gln Ser Pro Ala Phe Asp Pro Tyr Leu Pro Asp Asp Ile Ile Leu Asn 
305                 310                 315                 320 


Asn Asn Ser Glu Val Ile Ile Asn Ser Ile Glu Glu Glu Ser Tyr Glu 
                325                 330                 335     


Gly Ile Pro Ile Tyr Glu Val Thr Val Glu Asp Asn Leu Met Leu Arg 
            340                 345                 350         


Ile Ile Lys Pro Glu Ser Thr Asp Ile Tyr Leu Lys Glu Leu Gln Lys 
        355                 360                 365             


Tyr Arg Gln Ala Ala Leu Ser Asn Gly Lys Phe Trp Lys Lys Phe Tyr 
    370                 375                 380                 


Glu Phe Lys Asn Lys Phe Val Glu Ile Lys Gln Ala Tyr Ala Cys Thr 
385                 390                 395                 400 


Cys His Lys Ala Gln Gly Ser Thr Tyr Glu Arg Val Tyr Val Asp Phe 
                405                 410                 415     


Lys Asp Leu Pro Trp Thr Thr Asp Thr Asp Leu Ala Phe Arg Leu Ala 
            420                 425                 430         


Tyr Val Gly Leu Thr Arg Ala Ser Asp Lys Val Ile Val Ser Thr Phe 
        435                 440                 445             


<210>  3
<211>  434
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCH272

<400>  3

Met Leu Glu Lys Gln Gln Leu Glu Ile Phe Glu Asn Val Ile Arg Asn 
1               5                   10                  15      


Ile Asn Tyr Ile Leu Asp Pro Ala Thr Phe Glu Phe Gly Trp Glu His 
            20                  25                  30          


Ser Val Val Ser Ile Ser Gly Ala Ala Gly Thr Gly Lys Thr Phe Leu 
        35                  40                  45              


Leu Ala Glu Ile Ile Lys Ser Leu Gln Asn Lys Tyr Lys Ile Ala Ile 
    50                  55                  60                  


Thr Thr Pro Thr His Gln Ser Leu Gly Val Leu Thr Asp Lys Val Ile 
65                  70                  75                  80  


Ser Cys Gly Ala Asp Asp Leu Lys Leu Asn Phe Ser Thr Ile His Ser 
                85                  90                  95      


Phe Leu Asn Leu Lys Leu Gln Ile Asp Tyr Ala Thr Gly Asn Gln Thr 
            100                 105                 110         


Phe Val Ala Asp Asn Phe Lys Lys Asp Thr Lys Lys Tyr Asp Ile Leu 
        115                 120                 125             


Val Leu Asp Glu Ser Ser Met Ile Ser Glu Glu Met Phe Asn Asn Ile 
    130                 135                 140                 


Lys Leu Ile Ile Gly Arg Arg Val Lys Ala Val Leu Phe Val Gly Asp 
145                 150                 155                 160 


Phe Tyr Gln Leu Glu Pro Val Asp Gly Glu Pro Asn Lys Ile Thr Asp 
                165                 170                 175     


Ile Lys Trp Ser Tyr Glu Leu Thr Asp Ile Gln Arg Gln Val Ala Asp 
            180                 185                 190         


Ser Glu Ile Ile Lys Glu Ala Thr Tyr Phe Arg Asp Ser Ile Lys Asn 
        195                 200                 205             


Lys Gln Phe Lys Pro Leu Ser Asp Leu Phe Gly Arg Glu Ser Thr Asp 
    210                 215                 220                 


Asp Val Lys Ile Phe Ala Ser Lys Asp Glu Phe Leu Ser Glu Tyr Tyr 
225                 230                 235                 240 


Ser Asp Asp Lys Ile Lys Met Val Thr Ala Phe Thr Asn Asn Ser Val 
                245                 250                 255     


Asp Ser Tyr Asn Lys Met Ile Arg Asn Lys Val Tyr Gly Glu Asn Ile 
            260                 265                 270         


Gly Asn Tyr Ile Val Gly Glu Lys Leu Ile Phe Gln Asp Asn Leu Tyr 
        275                 280                 285             


Glu Asp Asp Val Cys Ile His Leu Asn Gly Asp Ile Ile Thr Ile Lys 
    290                 295                 300                 


Asp Ile Glu Leu Lys Tyr Asp Asn Lys Ile Met Ser Trp Tyr Trp Asp 
305                 310                 315                 320 


Val Lys Ser Thr Lys Pro Ser Lys Phe Lys Ile Ile Asp Glu Gly Ser 
                325                 330                 335     


Met Asn Asn Phe Asn Phe Tyr Leu Asp Glu Tyr Lys Ser Leu Ala Ile 
            340                 345                 350         


Gln Thr Gln Asp Tyr Lys Glu Lys Arg Lys Leu Trp Lys Lys Tyr Tyr 
        355                 360                 365             


Asp Leu Lys Gly Lys Tyr Ala Asn Val Lys Tyr Ala Phe Ala Gly Thr 
    370                 375                 380                 


Val His Lys Met Gln Gly Thr Thr Val His Ser Ile Tyr Phe Asp Leu 
385                 390                 395                 400 


Arg Glu Leu Val Gly Phe Asp Tyr Gly His Asn Arg Glu Ser Leu Tyr 
                405                 410                 415     


Arg Leu Ile Tyr Val Ala Ile Thr Arg Pro Ser Asp Lys Leu Val Ile 
            420                 425                 430         


Leu Ile 
        


<210>  4
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  øDda

<400>  4

Met Thr Phe Asp Asp Leu Thr Glu Gly Gln Lys Asn Ala Phe Asn Ile 
1               5                   10                  15      


Val Met Lys Ala Ile Lys Glu Lys Lys His His Val Thr Ile Asn Gly 
            20                  25                  30          


Pro Ala Gly Thr Gly Lys Thr Thr Leu Thr Lys Phe Ile Ile Glu Ala 
        35                  40                  45              


Leu Ile Ser Thr Gly Gly Thr Gly Ile Ile Leu Ala Ala Pro Thr His 
    50                  55                  60                  


Ala Ala Lys Lys Ile Leu Ser Lys Leu Ser Gly Lys Glu Ala Ser Thr 
65                  70                  75                  80  


Ile His Ser Ile Leu Lys Ile Asn Pro Val Thr Tyr Glu Glu Asn Val 
                85                  90                  95      


Leu Phe Glu Gln Lys Glu Val Pro Asp Leu Ala Lys Cys Arg Val Leu 
            100                 105                 110         


Ile Cys Asp Glu Val Ser Met Tyr Asp Arg Lys Leu Phe Lys Ile Leu 
        115                 120                 125             


Leu Ser Thr Ile Pro Pro Trp Cys Thr Ile Ile Gly Ile Gly Asp Asn 
    130                 135                 140                 


Lys Gln Ile Arg Pro Val Glu Pro Gly Glu Asn Thr Ala Tyr Ile Ser 
145                 150                 155                 160 


Pro Phe Phe Thr His Lys Asp Phe Tyr Gln Cys Glu Leu Thr Glu Val 
                165                 170                 175     


Lys Arg Ser Asn Ala Pro Ile Ile Asp Val Ala Thr Asp Val Arg Asn 
            180                 185                 190         


Gly Lys Trp Asn Tyr Asp Lys Val Val Asp Gly His Gly Val Arg Gly 
        195                 200                 205             


Phe Thr Gly Asp Thr Ala Leu Arg Asp Phe Met Val Asn Tyr Phe Ser 
    210                 215                 220                 


Ile Val Lys Ser Leu Asp Asp Leu Phe Glu Asn Arg Val Met Ala Phe 
225                 230                 235                 240 


Thr Asn Lys Ser Val Asp Lys Leu Asn Ser Ile Ile Arg Lys Lys Ile 
                245                 250                 255     


Phe Glu Thr Asp Lys Asp Phe Ile Val Gly Glu Ile Ile Val Met Gln 
            260                 265                 270         


Glu Pro Leu Phe Lys Thr Tyr Lys Ile Asp Gly Lys Pro Val Ser Glu 
        275                 280                 285             


Ile Ile Phe Asn Asn Gly Gln Leu Val Arg Ile Ile Glu Ala Glu Tyr 
    290                 295                 300                 


Thr Ser Thr Phe Val Lys Ala Arg Gly Val Pro Gly Glu Tyr Leu Ile 
305                 310                 315                 320 


Arg His Trp Asp Leu Thr Val Glu Thr Tyr Gly Asp Asp Glu Tyr Tyr 
                325                 330                 335     


Arg Glu Lys Ile Lys Ile Ile Ser Ser Asp Glu Glu Leu Tyr Lys Phe 
            340                 345                 350         


Asn Leu Phe Leu Ala Lys Thr Ala Glu Thr Tyr Lys Asn Trp Asn Lys 
        355                 360                 365             


Gly Gly Lys Ala Pro Trp Ser Asp Phe Trp Asp Ala Lys Ser Gln Phe 
    370                 375                 380                 


Ser Lys Val Lys Ala Leu Pro Ala Ser Thr Phe His Lys Ala Gln Gly 
385                 390                 395                 400 


Met Ser Val Asp Arg Ala Phe Ile Tyr Thr Pro Cys Ile His Tyr Ala 
                405                 410                 415     


Asp Val Glu Leu Ala Gln Gln Leu Leu Tyr Val Gly Val Thr Arg Gly 
            420                 425                 430         


Arg Tyr Asp Val Phe Tyr Val 
        435                 


<210>  5
<211>  2710
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ŀ

<400>  5
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt cgagctcggt acctcgcgaa      420

tgcatctaga tatcggatcc cgggcccgtc gactgcagag gcctgcatgc aagcttggcg      480

taatcatggt catagctgtt tcctgtgtga aattgttatc cgctcacaat tccacacaac      540

atacgagccg gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca      600

ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat      660

taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc ttccgcttcc      720

tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc agctcactca      780

aaggcggtaa tacggttatc cacagaatca ggggataacg caggaaagaa catgtgagca      840

aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg      900

ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg      960

acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt     1020

ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt     1080

tctcatagct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc     1140

tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt     1200

gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt     1260

agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc     1320

tacactagaa gaacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa     1380

agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt     1440

tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct     1500

acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta     1560

tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa     1620

agtatatatg agtaaacttg gtctgacagt taccaatgct taatcagtga ggcacctatc     1680

tcagcgatct gtctatttcg ttcatccata gttgcctgac tccccgtcgt gtagataact     1740

acgatacggg agggcttacc atctggcccc agtgctgcaa tgataccgcg agacccacgc     1800

tcaccggctc cagatttatc agcaataaac cagccagccg gaagggccga gcgcagaagt     1860

ggtcctgcaa ctttatccgc ctccatccag tctattaatt gttgccggga agctagagta     1920

agtagttcgc cagttaatag tttgcgcaac gttgttgcca ttgctacagg catcgtggtg     1980

tcacgctcgt cgtttggtat ggcttcattc agctccggtt cccaacgatc aaggcgagtt     2040

acatgatccc ccatgttgtg caaaaaagcg gttagctcct tcggtcctcc gatcgttgtc     2100

agaagtaagt tggccgcagt gttatcactc atggttatgg cagcactgca taattctctt     2160

actgtcatgc catccgtaag atgcttttct gtgactggtg agtactcaac caagtcattc     2220

tgagaatagt gtatgcggcg accgagttgc tcttgcccgg cgtcaatacg ggataatacc     2280

gcgccacata gcagaacttt aaaagtgctc atcattggaa aacgttcttc ggggcgaaaa     2340

ctctcaagga tcttaccgct gttgagatcc agttcgatgt aacccactcg tgcacccaac     2400

tgatcttcag catcttttac tttcaccagc gtttctgggt gagcaaaaac aggaaggcaa     2460

aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt gaatactcat actcttcctt     2520

tttcaatatt attgaagcat ttatcagggt tattgtctca tgagcggata catatttgaa     2580

tgtatttaga aaaataaaca aataggggtt ccgcgcacat ttccccgaaa agtgccacct     2640

gacgtctaag aaaccattat tatcatgaca ttaacctata aaaataggcg tatcacgagg     2700

ccctttcgtc                                                            2710


<210>  6
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MspA

<400>  6

Gly Leu Asp Asn Glu Leu Ser Leu Val Asp Gly Gln Asp Arg Thr Leu 
1               5                   10                  15      


Thr Val Gln Gln Trp Asp Thr Phe Leu Asn Gly Val Phe Pro Leu Asp 
            20                  25                  30          


Arg Asn Arg Leu Thr Arg Glu Trp Phe His Ser Gly Arg Ala Lys Tyr 
        35                  40                  45              


Ile Val Ala Gly Pro Gly Ala Asp Glu Phe Glu Gly Thr Leu Glu Leu 
    50                  55                  60                  


Gly Tyr Gln Ile Gly Phe Pro Trp Ser Leu Gly Val Gly Ile Asn Phe 
65                  70                  75                  80  


Ser Tyr Thr Thr Pro Asn Ile Leu Ile Asp Asp Gly Asp Ile Thr Arg 
                85                  90                  95      


Pro Pro Phe Gly Leu Asn Ser Val Ile Thr Pro Asn Leu Phe Pro Gly 
            100                 105                 110         


Val Ser Ile Ser Ala Asp Leu Gly Asn Gly Pro Gly Ile Gln Glu Val 
        115                 120                 125             


Ala Thr Phe Ser Val Asp Val Ser Gly Ala Glu Gly Gly Val Ala Val 
    130                 135                 140                 


Ser Asn Ala His Gly Thr Val Thr Gly Ala Ala Gly Gly Val Leu Leu 
145                 150                 155                 160 


Arg Pro Phe Ala Arg Leu Ile Ala Ser Thr Gly Asp Ser Val Thr Thr 
                165                 170                 175     


Tyr Gly Glu Pro Trp Asn Met Asn 
            180                 


