                         SEQUENCE LISTING

<110>  Zhejiang Shimai Pharmaceutical Co, Ltd
 
<120>  ANTIBODIES AGAINST MESOTHELIN AND USES THEREOF

<130>  C21W0953

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M10 mAb LCDR1

<400>  1

Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala Phe 
1               5                   10      


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M10 mAb LCDR2

<400>  2

Lys Asp Ser Glu Arg Pro Ser 
1               5           


<210>  3
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M10 mAb LCDR3

<400>  3

Gln Ser Ala Asp Ser Ser Ala Thr Ser Val Ile 
1               5                   10      


<210>  4
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M10 mAb VL

<400>  4

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala 
            20                  25                  30          


Phe Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Ala Thr Ser 
                85                  90                  95      


Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  5
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M10 mAb Light chain

<400>  5

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala 
            20                  25                  30          


Phe Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Ala Thr Ser 
                85                  90                  95      


Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Lys Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M10 mAb HCDR1

<400>  6

Asp Tyr Ala Met His 
1               5   


<210>  7
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M10 mAb HCDR2

<400>  7

Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  8
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M10 mAb HCDR3

<400>  8

Asp Ser Gly Ser Ser Gly Trp Tyr Gly Tyr Phe Gln His 
1               5                   10              


<210>  9
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M10 mAb VH

<400>  9

Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu 
1               5                   10                  15      


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Ala Met 
            20                  25                  30          


His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly 
        35                  40                  45              


Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Asp Ser Gly Ser Ser Gly Trp Tyr Gly Tyr Phe Gln His Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  10
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M10 Fab Heavy chain

<400>  10

Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu 
1               5                   10                  15      


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Ala Met 
            20                  25                  30          


His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly 
        35                  40                  45              


Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Asp Ser Gly Ser Ser Gly Trp Tyr Gly Tyr Phe Gln His Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Gly 
    210                 215                 220                 


Gln Ala Gly His His His His His His Gly Asp Tyr Lys Asp Asp Asp 
225                 230                 235                 240 


Asp Lys Gly 
            


<210>  11
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M10 mAb Heavy chain

<400>  11

Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu 
1               5                   10                  15      


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Ala Met 
            20                  25                  30          


His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly 
        35                  40                  45              


Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Asp Ser Gly Ser Ser Gly Trp Tyr Gly Tyr Phe Gln His Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  12
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M10 HBiTE CD3 LCDR1

<400>  12

Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M10 HBiTE CD3 LCDR2

<400>  13

Gly Ala Asn Lys Arg Ala Pro 
1               5           


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M10 HBiTE CD3 LCDR3

<400>  14

Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210>  15
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M10 HBiTE CD3 VL

<400>  15

Glu Ile Val Val Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Thr Gly Ala Val Thr Thr 
            20                  25                  30          


Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        35                  40                  45              


Gly Leu Ile Gly Gly Ala Asn Lys Arg Ala Pro Gly Val Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Leu Ser Gly Asp Glu Ala Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Ala Leu Trp Tyr Ser 
                85                  90                  95      


Asn Leu Trp Val Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110 


<210>  16
<211>  561
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M10 HBiTE Light chain

<400>  16

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala 
            20                  25                  30          


Phe Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Ala Thr Ser 
                85                  90                  95      


Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Val Thr 
        115                 120                 125             


Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu 
    130                 135                 140                 


Ser Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
145                 150                 155                 160 


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
                165                 170                 175     


Ala Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
            180                 185                 190         


Ser Gly Asp Glu Ala Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp 
        195                 200                 205             


Phe Ala Val Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Leu Trp Val Phe 
    210                 215                 220                 


Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 
225                 230                 235                 240 


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
                245                 250                 255     


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
            260                 265                 270         


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
        275                 280                 285             


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
    290                 295                 300                 


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
305                 310                 315                 320 


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
                325                 330                 335     


Arg Gly Glu Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            340                 345                 350         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        355                 360                 365             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    370                 375                 380                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
385                 390                 395                 400 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                405                 410                 415     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            420                 425                 430         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        435                 440                 445             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    450                 455                 460                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Leu 
465                 470                 475                 480 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                485                 490                 495     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            500                 505                 510         


Asp Ser Asp Gly Ser Phe Phe Leu His Ser Lys Leu Thr Val Asp Lys 
        515                 520                 525             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    530                 535                 540                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
545                 550                 555                 560 


Lys 
    


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M10 HBiTE CD3 HCDR1

<400>  17

Gly Phe Thr Phe Asn Thr Tyr 
1               5           


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M10 HBiTE CD3 HCDR2

<400>  18

Arg Ser Lys Tyr Asn Asn Tyr Ala 
1               5               


<210>  19
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M10 HBiTE CD3 HCDR3

<400>  19

His Gly Asn Phe Gly Ser Ser Tyr Val Ser Tyr Phe Ala Tyr 
1               5                   10                  


<210>  20
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M10 HBiTE CD3 VH

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg His Gly Asn Phe Gly Ser Ser Tyr Val Ser Tyr Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  21
<211>  582
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M10 HBiTE Heavy chain

<400>  21

Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu 
1               5                   10                  15      


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Ala Met 
            20                  25                  30          


His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly 
        35                  40                  45              


Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Asp Ser Gly Ser Ser Gly Trp Tyr Gly Tyr Phe Gln His Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    130                 135                 140                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
145                 150                 155                 160 


Thr Phe Asn Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala 
            180                 185                 190         


Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
        195                 200                 205             


Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
    210                 215                 220                 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg His Gly Asn Phe Gly Ser Ser 
225                 230                 235                 240 


Tyr Val Ser Tyr Phe Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
                245                 250                 255     


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
            260                 265                 270         


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
        275                 280                 285             


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
    290                 295                 300                 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
305                 310                 315                 320 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
                325                 330                 335     


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
            340                 345                 350         


Asp Lys Lys Val Glu Pro Lys Ser Cys Pro Pro Cys Pro Ala Pro Glu 
        355                 360                 365             


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    370                 375                 380                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
385                 390                 395                 400 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                405                 410                 415     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            420                 425                 430         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        435                 440                 445             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    450                 455                 460                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
465                 470                 475                 480 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                485                 490                 495     


Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            500                 505                 510         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        515                 520                 525             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu His Ser Lys 
    530                 535                 540                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
545                 550                 555                 560 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                565                 570                 575     


Ser Leu Ser Pro Gly Lys 
            580         


<210>  22
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M10 HBiTE light chain linker

<400>  22
ggggsggggs ggggs                                                        15


<210>  23
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M10 HBiTE heavy chain linker

<400>  23
gssggggsgg ggs                                                          13


<210>  24
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  24
gtgtaagctt accatgggtg tgcccactca ggtcctgggg t                           41


<210>  25
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  25
cttacagatg ccagatgttc ctatgtgctg actcag                                 36


<210>  26
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  26
cggaattctt atgaacattc tgtaggggcc ac                                     32


<210>  27
<211>  85
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  27
tgttctagag ccaccatgga atggagctgg gtctttctct tcttcctgtc agtaactaca       60

ggtgtccact cccagctggt ggaga                                             85


<210>  28
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  28
atgtgtgagt tttgtcacaa gatttgggct caact                                  35


<210>  29
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  29
gacaaaactc acacatgccc accgt                                             25


<210>  30
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  30
ctgagtcgac ttatttaccc ggggacaggg aga                                    33


<210>  31
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  31
actacaggtg tccactcctc ctatgtgctg actcagc                                37


<210>  32
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  32
gtaggatcct aggacggtca gcttggtc                                          28


<210>  33
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  33
gtgttctaga gccgccacca tggaatggag ctgggtcttt c                           41


<210>  34
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  34
ggcttacaga tgccagatgt cagctggtgg agaccgg                                37


<210>  35
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  35
gatagagctc cctccacctg aggagacggt gacc                                   34


