﻿                         SEQUENCE LISTING

<110>  Shanghai Nigene Biological Science and Technology Co., Ltd.
 
<120>  TIGIT ANTIBODIES AND USES THEREOF

<130>  OP212229

<160>  83    

<170>  PatentIn version 3.3

<210>  1
<211>  735
<212>  DNA
<213>  Homo sapiens

<400>  1
atgcgctggt gtctcctcct gatctgggcc caggggctga ggcaggctcc cctcgcctca     60

ggaatgatga caggcacaat agaaacaacg gggaacattt ctgcagagaa aggtggctct    120

atcatcttac aatgtcacct ctcctccacc acggcacaag tgacccaggt caactgggag    180

cagcaggacc agcttctggc catttgtaat gctgacttgg ggtggcacat ctccccatcc    240

ttcaaggatc gagtggcccc aggtcccggc ctgggcctca ccctccagtc gctgaccgtg    300

aacgatacag gggagtactt ctgcatctat cacacctacc ctgatgggac gtacactggg    360

agaatcttcc tggaggtcct agaaagctca gtggctgagc acggtgccag gttccagatt    420

ccattgcttg gagccatggc cgcgacgctg gtggtcatct gcacagcagt catcgtggtg    480

gtcgcgttga ctagaaagaa gaaagccctc agaatccatt ctgtggaagg tgacctcagg    540

agaaaatcag ctggacagga ggaatggagc cccagtgctc cctcaccccc aggaagctgt    600

gtccaggcag aagctgcacc tgctgggctc tgtggagagc agcggggaga ggactgtgcc    660

gagctgcatg actacttcaa tgtcctgagt tacagaagcc tgggtaactg cagcttcttc    720

acagagactg gttag                                                     735


<210>  2
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu Lys 
1               5                   10                  15      


Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser Thr Thr Ala Gln 
            20                  25                  30          


Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile Cys 
        35                  40                  45              


Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp Arg Val 
    50                  55                  60                  


Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr Val Asn 
65                  70                  75                  80  


Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly Thr 
                85                  90                  95      


Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val Ala Glu 
            100                 105                 110         


His Gly Ala Arg Phe Gln Ile Pro 
        115                 120 


<210>  3
<211>  738
<212>  DNA
<213>  Macaca fascicularis

<400>  3
atgcggtggt gtctcttcct gatctgggcc caggggctga ggcaggctcc cctcgcctca     60

ggaatgatga caggcacaat agaaacaacg gggaacattt ctgcaaagaa aggtggctct    120

gttatcttac aatgtcacct ctcctccacc atggcacaag tgacccaggt caactgggag    180

cagcatgacc attcgcttct ggccattcgt aatgctgagt tggggtggca catctaccca    240

gccttcaagg atcgagtggc cccgggtcct ggcctgggcc tcaccctcca gtcgctgacc    300

atgaatgata caggggagta cttctgcacc tatcacacct accctgatgg gacttacaga    360

gggagaatct tcctggaggt cctagaaagc tcagtggctg agcacagtgc caggttccag    420

attccattgc ttggagccat ggccatgatg ctggtggtca tctgcatagc agtcatcgtg    480

gtggtcgtgt tggctagaaa gaagaaatcc ctcagaatcc attctgtgga aagtggcctc    540

cagagaaaat caactggaca ggaagaacag attcccagtg ctccctcacc cccaggaagc    600

tgtgtccagg cagaagctgc acctgctggg ctctgtggag agcagcaggg agatgactgt    660

gccgagctgc atgactactt caatgtcctg agttacagaa gcctggggag ctgcagcttc    720

ttcacagaga ctgggtag                                                  738


<210>  4
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH1B2-8C VL

<400>  4

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  5
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH1B2-8C VH

<400>  5

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Glu Gly Val Leu Arg Tyr Phe Asp Trp Leu Ser 
            100                 105                 110         


Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125             


<210>  6
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4A042-H3 VL

<400>  6

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Phe Gly 
            20                  25                  30          


Phe Asn Asn Lys Ile Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Glu Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  7
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4A042-H3 VH

<400>  7

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Phe Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Met Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Glu Arg Ala Leu Tyr Asp Ile Leu Ala Gly Ser 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  8
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4A042-H7 VL

<400>  8

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Phe Gly 
            20                  25                  30          


Phe Asn Asn Lys Ile Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Glu Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  9
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4A042-H7 VH

<400>  9

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Val Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Met Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Glu Arg Ala Leu Tyr Asp Ile Leu Ala Gly Ser 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  10
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4B030a VL

<400>  10

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Thr Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  11
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4B030a VH

<400>  11

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Glu Arg Gly Thr Tyr Tyr Asp Ile Leu Thr Gly 
            100                 105                 110         


Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  12
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4B037a VL

<400>  12

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Gly Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  13
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4B037a VH

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Ser Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Val Thr Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Leu Pro Thr Tyr Arg Tyr Tyr Ala Leu Asp Gly Trp Gly 
            100                 105                 110         


Gln Gly Thr Ala Val Thr Val Ser Ser 
        115                 120     


<210>  14
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4B056a VL

<400>  14

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Lys Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  15
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4B056a VH

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Ile Gly Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gly Gly Asp Tyr His Tyr Tyr Gly Met Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  16
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4A057 VL

<400>  16

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Phe Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Asn 
            20                  25                  30          


Tyr Leu Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Arg Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Asn 
            100                 105             


<210>  17
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4A057 VH

<400>  17

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Leu Thr Ser His 
            20                  25                  30          


Ala Leu Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Val Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Ser Ser Pro Pro Arg Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  18
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4A063 VL

<400>  18

Asp Ile Met Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Lys Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Leu Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  19
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4A063 VH

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Asn Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Ile Ser Ile Gly Ser Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gly Gly Asp His Tyr Tyr Tyr Gly Met Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  20
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH1B2-8C VL CDR1

<400>  20

Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr 
1               5                   10          


<210>  21
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH1B2-8C VL CDR2

<400>  21

Trp Ala Ser 
1           


<210>  22
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH1B2-8C VL CDR3

<400>  22

Gln Gln Tyr Tyr Ser Thr Pro Trp Thr 
1               5                   


<210>  23
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH1B2-8C VH CDR1

<400>  23

Gly Asp Ser Val Ser Ser Asn Ser Ala Ala 
1               5                   10  


<210>  24
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH1B2-8C VH CDR2

<400>  24

Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn 
1               5                   


<210>  25
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH1B2-8C VH CDR3

<400>  25

Ala Arg Glu Gly Val Leu Arg Tyr Phe Asp Trp Leu Ser Gly Ala Phe 
1               5                   10                  15      


Asp Ile 
        


<210>  26
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4A042-H3 VL CDR1

<400>  26

Gln Ser Val Leu Phe Gly Phe Asn Asn Lys Ile Tyr 
1               5                   10          


<210>  27
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4A042-H3 VL CDR2

<400>  27

Trp Ala Ser 
1           


<210>  28
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4A042-H3 VL CDR3

<400>  28

Gln Gln Tyr Tyr Ser Phe Pro Tyr Thr 
1               5                   


<210>  29
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4A042-H3 VH CDR1

<400>  29

Gly Asp Ser Val Ser Ser Asn Ser Ala Ala 
1               5                   10  


<210>  30
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4A042-H3 VH CDR2

<400>  30

Thr Tyr Phe Arg Ser Lys Trp Tyr Asn 
1               5                   


<210>  31
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4A042-H3 VH CDR3

<400>  31

Ala Arg Glu Arg Ala Leu Tyr Asp Ile Leu Ala Gly Ser Phe Asp Tyr 
1               5                   10                  15      


<210>  32
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4A042-H7 VL CDR1

<400>  32

Gln Ser Val Leu Phe Gly Phe Asn Asn Lys Ile Tyr 
1               5                   10          


<210>  33
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4A042-H7 VL CDR2

<400>  33

Trp Ala Ser 
1           


<210>  34
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4A042-H7 VL CDR3

<400>  34

Gln Gln Tyr Tyr Ser Phe Pro Tyr Thr 
1               5                   


<210>  35
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4A042-H7 VH CDR1

<400>  35

Gly Asp Ser Val Ser Ser Asn Ser Ala Val 
1               5                   10  


<210>  36
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4A042-H7 VH CDR2

<400>  36

Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn 
1               5                   


<210>  37
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4A042-H7 VH CDR3

<400>  37

Ala Arg Glu Arg Ala Leu Tyr Asp Ile Leu Ala Gly Ser Phe Asp Tyr 
1               5                   10                  15      


<210>  38
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4B030a VL CDR1

<400>  38

Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr 
1               5                   10          


<210>  39
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4B030a VL CDR2

<400>  39

Trp Ala Ser 
1           


<210>  40
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4B030a VL CDR3

<400>  40

Gln Gln His Tyr Ser Phe Pro Tyr Thr 
1               5                   


<210>  41
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4B030a VH CDR1

<400>  41

Gly Asp Ser Val Ser Ser Asn Ser Ala Ala 
1               5                   10  


<210>  42
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4B030a VH CDR2

<400>  42

Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn 
1               5                   


<210>  43
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4B030a VH CDR3

<400>  43

Ala Arg Glu Arg Gly Thr Tyr Tyr Asp Ile Leu Thr Gly Asp Phe Asp 
1               5                   10                  15      


Tyr 
    


<210>  44
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4B037a VL CDR1

<400>  44

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  45
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4B037a VL CDR2

<400>  45

Leu Gly Ser 
1           


<210>  46
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4B037a VL CDR3

<400>  46

Met Gln Ala Leu Gln Thr Pro Leu Thr 
1               5                   


<210>  47
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4B037a VH CDR1

<400>  47

Gly Phe Ser Phe Asp Asp Tyr Ala 
1               5               


<210>  48
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4B037a VH CDR2

<400>  48

Ile Ser Trp Asn Ser Val Thr Ile 
1               5               


<210>  49
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4B037a VH CDR3

<400>  49

Ala Lys Glu Leu Pro Thr Tyr Arg Tyr Tyr Ala Leu Asp Gly 
1               5                   10                  


<210>  50
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4B056a VL CDR1

<400>  50

Gln Ser Leu Leu His Ser Asn Gly Tyr Lys Tyr 
1               5                   10      


<210>  51
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4B056a VL CDR2

<400>  51

Leu Gly Ser 
1           


<210>  52
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4B056a VL CDR3

<400>  52

Met Gln Ala Leu Gln Thr Pro Leu Thr 
1               5                   


<210>  53
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4B056a VH CDR1

<400>  53

Gly Phe Thr Phe Asp Asp Tyr Ala 
1               5               


<210>  54
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4B056a VH CDR2

<400>  54

Ile Ser Trp Asn Gly Ile Gly Ile 
1               5               


<210>  55
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4B056a VH CDR3

<400>  55

Ala Lys Asp Gly Gly Asp Tyr His Tyr Tyr Gly Met Asp Val 
1               5                   10                  


<210>  56
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4A057 VL CDR1

<400>  56

Gln Ser Val Ser Arg Asn Tyr 
1               5           


<210>  57
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4A057 VL CDR2

<400>  57

Gly Ala Ser 
1           


<210>  58
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4A057 VL CDR3

<400>  58

Gln Gln Tyr Gly Ser Ser Pro Phe Thr 
1               5                   


<210>  59
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4A057 VH CDR1

<400>  59

Gly Tyr Thr Leu Thr Ser His Ala 
1               5               


<210>  60
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4A057 VH CDR2

<400>  60

Ile Asn Thr Asn Thr Gly Asn Pro 
1               5               


<210>  61
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4A057 VH CDR3

<400>  61

Ala Arg Gly Tyr Ser Ser Pro Pro Arg Met Asp Val 
1               5                   10          


<210>  62
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4A063 VL CDR1

<400>  62

Gln Ser Leu Leu His Ser Asn Gly Tyr Lys Tyr 
1               5                   10      


<210>  63
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4A063 VL CDR2

<400>  63

Leu Gly Ser 
1           


<210>  64
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4A063 VL CDR3

<400>  64

Met Gln Ala Leu Gln Thr Pro Leu Thr 
1               5                   


<210>  65
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4A063 VH CDR1

<400>  65

Gly Phe Asn Phe Asp Asp Tyr Gly 
1               5               


<210>  66
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4A063 VL CDR2

<400>  66

Ile Ser Trp Asn Ser Ile Ser Ile 
1               5               


<210>  67
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4A063 VL CDR3

<400>  67

Ala Lys Asp Gly Gly Asp His Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  


<210>  68
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4D035a VL

<400>  68

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Met Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Arg 
            100                 105                 110         


<210>  69
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4D035a VH

<400>  69

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Phe 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Ile Gly Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Phe Cys 
                85                  90                  95      


Ala Lys Asp Lys Gly Leu Arg Arg Tyr Tyr Gly Met Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Ile Thr Val Ile Val Ser Ser 
        115                 120     


<210>  70
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4E061a VL

<400>  70

Glu Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Arg Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Asn Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  71
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4E061a VH

<400>  71

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Ile Gly Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Ile 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ile Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Lys Gly Leu Arg Arg Tyr Tyr Gly Met Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  72
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4D035a VL CDR1

<400>  72

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  73
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4D035a VL CDR2

<400>  73

Leu Gly Ser 
1           


<210>  74
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4D035a VL CDR3

<400>  74

Met Gln Ala Leu Gln Thr Pro Pro Thr 
1               5                   


<210>  75
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4D035a VH CDR1

<400>  75

Gly Phe Thr Phe Asp Asp Phe Ala 
1               5               


<210>  76
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4D035a VL CDR2

<400>  76

Ile Ser Trp Asn Gly Ile Gly Ile 
1               5               


<210>  77
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4D035a VL CDR3

<400>  77

Ala Lys Asp Lys Gly Leu Arg Arg Tyr Tyr Gly Met Asp Val 
1               5                   10                  


<210>  78
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4E061a VL CDR1

<400>  78

Arg Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  79
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4E061a VL CDR2

<400>  79

Leu Gly Ser 
1           


<210>  80
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4E061a VL CDR3

<400>  80

Met Gln Ala Leu Gln Thr Pro Pro Thr 
1               5                   


<210>  81
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4E061a VH CDR1

<400>  81

Gly Phe Thr Phe Asp Asp Tyr Ala 
1               5               


<210>  82
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4E061a VH CDR2

<400>  82

Ile Ser Trp Asn Gly Ile Gly Ile 
1               5               


<210>  83
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody JHH4E061a VH CDR3

<400>  83

Ala Lys Asp Lys Gly Leu Arg Arg Tyr Tyr Gly Met Asp Val 
1               5                   10                  


