                         SEQUENCE LISTING

<110>  AVALO THERAPEUTICS, INC.
 
<120>  METHODS AND TREATMENT FOR MULTIPLE MYELOMA INVOLVING ANTIBODIES 
       TO IL-18

<130>  01118-0050-00PCT

<160>  168   

<170>  PatentIn version 3.5

<210>  1
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 1 VH

<400>  1

Gln Val Gln Leu Gln Gln Ser Gly Pro Arg Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Gly Asp Thr Pro Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Pro Ala Tyr Asp Gly Asp Ala Arg Ala Asp Phe Phe 
            100                 105                 110         


Asp Val Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 1 HCDR1

<400>  2

Ser Gly Gly Tyr Tyr Trp Ser 
1               5           


<210>  3
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 1 HCDR2

<400>  3

Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  4
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 1 HCDR3

<400>  4

Thr Pro Ala Tyr Asp Gly Asp Ala Arg Ala Asp Phe Phe Asp Val 
1               5                   10                  15  


<210>  5
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 1 VL

<400>  5

Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 1 LCDR1

<400>  6

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 1 LCDR2

<400>  7

Lys Ala Ser Thr Leu Glu Ser 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 1 LCDR3

<400>  8

Gln Gln Ser Tyr Ser Thr Pro Trp Thr 
1               5                   


<210>  9
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 1_GL VH

<400>  9

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Gly Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Pro Ala Tyr Asp Gly Asp Ala Arg Ala Asp Phe Phe 
            100                 105                 110         


Asp Val Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 1_GL HCDR1

<400>  10

Ser Gly Gly Tyr Tyr Trp Ser 
1               5           


<210>  11
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 1_GL HCDR2

<400>  11

Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 1_GL HCDR3

<400>  12

Thr Pro Ala Tyr Asp Gly Asp Ala Arg Ala Asp Phe Phe Asp Val 
1               5                   10                  15  


<210>  13
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 1_GL VL

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 1_GL LCDR1

<400>  14

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 1_GL LCDR2

<400>  15

Lys Ala Ser Thr Leu Glu Ser 
1               5           


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 1_GL LCDR3

<400>  16

Gln Gln Ser Tyr Ser Thr Pro Trp Thr 
1               5                   


<210>  17
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 2 VH

<400>  17

Gln Val Gln Leu Gln Gln Ser Gly Pro Arg Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Gly Asp Thr Pro Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Pro Ala Tyr Asp Gly Asp Ala Arg Ala Asp Phe Phe 
            100                 105                 110         


Asp Val Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 2 HCDR1

<400>  18

Ser Gly Gly Tyr Tyr Trp Ser 
1               5           


<210>  19
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 2 HCDR2

<400>  19

Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 2 HCDR3

<400>  20

Thr Pro Ala Tyr Asp Gly Asp Ala Arg Ala Asp Phe Phe Asp Val 
1               5                   10                  15  


<210>  21
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 2 VL

<400>  21

Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asp Ile Ser Phe Pro Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 2 LCDR1

<400>  22

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 2 LCDR2

<400>  23

Lys Ala Ser Thr Leu Glu Ser 
1               5           


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 2 LCDR3

<400>  24

Gln Asp Ile Ser Phe Pro Pro Trp Thr 
1               5                   


<210>  25
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 3 VH

<400>  25

Gln Val Gln Leu Gln Gln Ser Gly Pro Arg Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Gly Asp Thr Pro Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Pro Ala Tyr Asp Gly Asp Ala Arg Ala Asp Phe Phe 
            100                 105                 110         


Asp Val Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  26
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 3 HCDR1

<400>  26

Ser Gly Gly Tyr Tyr Trp Ser 
1               5           


<210>  27
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 3 HCDR2

<400>  27

Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  28
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 3 HCDR3

<400>  28

Thr Pro Ala Tyr Asp Gly Asp Ala Arg Ala Asp Phe Phe Asp Val 
1               5                   10                  15  


<210>  29
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 3 VL

<400>  29

Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Leu Tyr Pro Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 3 LCDR1

<400>  30

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 3 LCDR2

<400>  31

Lys Ala Ser Thr Leu Glu Ser 
1               5           


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 3 LCDR3

<400>  32

Gln Gln Ser Leu Tyr Pro Pro Trp Thr 
1               5                   


<210>  33
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 4 VH

<400>  33

Gln Val Gln Leu Gln Gln Ser Gly Pro Arg Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Gly Asp Thr Pro Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Pro Ala Tyr Asp Gly Asp Ala Arg Ala Asp Phe Phe 
            100                 105                 110         


Asp Val Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 4 HCDR1

<400>  34

Ser Gly Gly Tyr Tyr Trp Ser 
1               5           


<210>  35
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 4 HCDR2

<400>  35

Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  36
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 4 HCDR3

<400>  36

Thr Pro Ala Tyr Asp Gly Asp Ala Arg Ala Asp Phe Phe Asp Val 
1               5                   10                  15  


<210>  37
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 4 VL

<400>  37

Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His His Pro Asn Trp 
                85                  90                  95      


Asp Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  38
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 4 LCDR1

<400>  38

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 4 LCDR2

<400>  39

Lys Ala Ser Thr Leu Glu Ser 
1               5           


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 4 LCDR3

<400>  40

Gln Gln Ser His His Pro Asn Trp Asp 
1               5                   


<210>  41
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 5 VH

<400>  41

Gln Val Gln Leu Gln Gln Ser Gly Pro Arg Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Gly Asp Thr Pro Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Pro Ala Tyr Asp Gly Asp Ala Arg Ala Asp Phe Phe 
            100                 105                 110         


Asp Val Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 5 HCDR1

<400>  42

Ser Gly Gly Tyr Tyr Trp Ser 
1               5           


<210>  43
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 5 HCDR2

<400>  43

Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  44
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 5 HCDR3

<400>  44

Thr Pro Ala Tyr Asp Gly Asp Ala Arg Ala Asp Phe Phe Asp Val 
1               5                   10                  15  


<210>  45
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 5 VL

<400>  45

Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Leu Ile Pro Gln Trp 
                85                  90                  95      


Asp Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  46
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 5 LCDR1

<400>  46

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  47
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 5 LCDR2

<400>  47

Lys Ala Ser Thr Leu Glu Ser 
1               5           


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 5 LCDR3

<400>  48

Gln Gln Ser Leu Ile Pro Gln Trp Asp 
1               5                   


<210>  49
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 6 VH

<400>  49

Gln Val Gln Leu Gln Gln Ser Gly Pro Arg Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Gly Asp Thr Pro Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Pro Ala Tyr Phe Gly Gln Asp Arg Thr Asp Phe Phe 
            100                 105                 110         


Asp Val Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 6 HCDR1

<400>  50

Ser Gly Gly Tyr Tyr Trp Ser 
1               5           


<210>  51
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 6 HCDR2

<400>  51

Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  52
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 6 HCDR3

<400>  52

Thr Pro Ala Tyr Phe Gly Gln Asp Arg Thr Asp Phe Phe Asp Val 
1               5                   10                  15  


<210>  53
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 6 VL

<400>  53

Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Asn Ile Ala Phe Pro Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  54
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 6 LCDR1

<400>  54

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  55
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 6 LCDR2

<400>  55

Lys Ala Ser Thr Leu Glu Ser 
1               5           


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 6 LCDR3

<400>  56

Ala Asn Ile Ala Phe Pro Pro Trp Thr 
1               5                   


<210>  57
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 6_GL VH

<400>  57

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Gly Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Pro Ala Tyr Phe Gly Gln Asp Arg Thr Asp Phe Phe 
            100                 105                 110         


Asp Val Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  58
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 6_GL HCDR1

<400>  58

Ser Gly Gly Tyr Tyr Trp Ser 
1               5           


<210>  59
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 6_GL HCDR2

<400>  59

Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  60
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 6_GL HCDR3

<400>  60

Thr Pro Ala Tyr Phe Gly Gln Asp Arg Thr Asp Phe Phe Asp Val 
1               5                   10                  15  


<210>  61
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 6_GL VL

<400>  61

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Ala Asn Ile Ala Phe Pro Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  62
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 6_GL LCDR1

<400>  62

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  63
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 6_GL LCDR2

<400>  63

Lys Ala Ser Thr Leu Glu Ser 
1               5           


<210>  64
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 6_GL

<400>  64

Ala Asn Ile Ala Phe Pro Pro Trp Thr 
1               5                   


<210>  65
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 7 VH

<400>  65

Gln Val Gln Leu Gln Gln Ser Gly Pro Arg Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Gly Asp Thr Pro Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Pro Ala Tyr Phe Gly Gln Asp Arg Thr Asp Phe Phe 
            100                 105                 110         


Asp Val Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  66
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 7 HCDR1

<400>  66

Ser Gly Gly Tyr Tyr Trp Ser 
1               5           


<210>  67
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 7 HCDR2

<400>  67

Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  68
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 7 HCDR3

<400>  68

Thr Pro Ala Tyr Phe Gly Gln Asp Arg Thr Asp Phe Phe Asp Val 
1               5                   10                  15  


<210>  69
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 7 VL

<400>  69

Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His His Pro Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  70
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 7 LCDR1

<400>  70

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  71
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 7 LCDR2

<400>  71

Lys Ala Ser Thr Leu Glu Ser 
1               5           


<210>  72
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 7 LCDR3

<400>  72

Gln Gln Ser His His Pro Pro Trp Thr 
1               5                   


<210>  73
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 7_GL VH

<400>  73

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Gly Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Pro Ala Tyr Phe Gly Gln Asp Arg Thr Asp Phe Phe 
            100                 105                 110         


Asp Val Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  74
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 7_GL HCDR1

<400>  74

Ser Gly Gly Tyr Tyr Trp Ser 
1               5           


<210>  75
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 7_GL HCDR2

<400>  75

Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  76
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 7_GL HCDR3

<400>  76

Thr Pro Ala Tyr Phe Gly Gln Asp Arg Thr Asp Phe Phe Asp Val 
1               5                   10                  15  


<210>  77
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 7_GL VL

<400>  77

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His His Pro Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  78
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 7_GL LCDR1

<400>  78

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  79
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 7_GL LCDR2

<400>  79

Lys Ala Ser Thr Leu Glu Ser 
1               5           


<210>  80
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 7_GL LCDR3

<400>  80

Gln Gln Ser His His Pro Pro Trp Thr 
1               5                   


<210>  81
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 8_GL VH

<400>  81

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ala Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Leu Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Gly Arg Val Thr Ile Ser Gly Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Pro Ala Tyr Phe Gly Gln Asp Arg Thr Asp Phe Phe 
            100                 105                 110         


Asp Val Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  82
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 8_GL HCDR1

<400>  82

Ala Gly Gly Tyr Tyr Trp Ser 
1               5           


<210>  83
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 8_GL HCDR2

<400>  83

Ser Leu Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Gly 
1               5                   10                  15      


<210>  84
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 8_GL HCDR3

<400>  84

Thr Pro Ala Tyr Phe Gly Gln Asp Arg Thr Asp Phe Phe Asp Val 
1               5                   10                  15  


<210>  85
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 8_GL VL

<400>  85

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His His Pro Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  86
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 8_GL LCDR1

<400>  86

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  87
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 8_GL LCDR2

<400>  87

Lys Ala Ser Thr Leu Glu Ser 
1               5           


<210>  88
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 8_GL LCDR3

<400>  88

Gln Gln Ser His His Pro Pro Trp Thr 
1               5                   


<210>  89
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 9 VH

<400>  89

Gln Val Gln Leu Gln Gln Ser Gly Pro Arg Leu Val Glu Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Asp 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Gly Asp Thr Pro Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Pro Ala Tyr Phe Gly Gln Asp Arg Thr Asp Phe Phe 
            100                 105                 110         


Asp Val Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  90
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 9 HCDR1

<400>  90

Ser Asp Gly Tyr Tyr Trp Ser 
1               5           


<210>  91
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 9 HCDR2

<400>  91

Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  92
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 9 HCDR3

<400>  92

Thr Pro Ala Tyr Phe Gly Gln Asp Arg Thr Asp Phe Phe Asp Val 
1               5                   10                  15  


<210>  93
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 9 VL

<400>  93

Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His His Pro Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  94
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 9 LCDR1

<400>  94

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  95
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 9 LCDR2

<400>  95

Lys Ala Ser Thr Leu Glu Ser 
1               5           


<210>  96
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 9 LCDR3

<400>  96

Gln Gln Ser His His Pro Pro Trp Thr 
1               5                   


<210>  97
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 10 VH

<400>  97

Gln Val Gln Leu Gln Gln Ser Gly Pro Arg Leu Val Glu Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Asp 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Arg Ser Arg Val Thr Ile Ser Gly Asp Thr Pro Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Pro Ala Tyr Phe Gly Gln Asp Arg Thr Asp Phe Phe 
            100                 105                 110         


Asp Val Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  98
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 10 HCDR1

<400>  98

Ser Asp Gly Tyr Tyr Trp Ser 
1               5           


<210>  99
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 10 HCDR2

<400>  99

Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Arg Ser 
1               5                   10                  15      


<210>  100
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 10 HCDR3

<400>  100

Thr Pro Ala Tyr Phe Gly Gln Asp Arg Thr Asp Phe Phe Asp Val 
1               5                   10                  15  


<210>  101
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 10 VL

<400>  101

Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gly Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His His Pro Pro Trp 
                85                  90                  95      


Thr Phe Ser Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  102
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 10 LCDR1

<400>  102

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  103
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 10 LCDR2

<400>  103

Lys Ala Ser Thr Leu Glu Ser 
1               5           


<210>  104
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 10 LCDR3

<400>  104

Gln Gln Ser His His Pro Pro Trp Thr 
1               5                   


<210>  105
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 11 VH

<400>  105

Gln Val Gln Leu Gln Gln Ser Gly Pro Arg Leu Val Glu Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ala Asp 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Leu Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Arg Gly Arg Val Thr Ile Ser Gly Asp Thr Pro Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Pro Ala Tyr Phe Gly Gln Asp Arg Thr Asp Phe Phe 
            100                 105                 110         


Asp Val Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  106
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 11 HCDR1

<400>  106

Ala Asp Gly Tyr Tyr Trp Ser 
1               5           


<210>  107
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 11 HCDR2

<400>  107

Ser Leu Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Arg Gly 
1               5                   10                  15      


<210>  108
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 11 HCDR3

<400>  108

Thr Pro Ala Tyr Phe Gly Gln Asp Arg Thr Asp Phe Phe Asp Val 
1               5                   10                  15  


<210>  109
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 11 VL

<400>  109

Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gly Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His His Pro Pro Trp 
                85                  90                  95      


Thr Phe Ser Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  110
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 11 LCDR1

<400>  110

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  111
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 11 LCDR2

<400>  111

Lys Ala Ser Thr Leu Glu Ser 
1               5           


<210>  112
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 11 LCDR3

<400>  112

Gln Gln Ser His His Pro Pro Trp Thr 
1               5                   


<210>  113
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 11_GL VH

<400>  113

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ala Asp 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Leu Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Arg Gly Arg Val Thr Ile Ser Gly Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Pro Ala Tyr Phe Gly Gln Asp Arg Thr Asp Phe Phe 
            100                 105                 110         


Asp Val Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  114
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 11_GL HCDR1

<400>  114

Ala Asp Gly Tyr Tyr Trp Ser 
1               5           


<210>  115
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 11_GL HCDR2

<400>  115

Ser Leu Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Arg Gly 
1               5                   10                  15      


<210>  116
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 11_GL HCDR3

<400>  116

Thr Pro Ala Tyr Phe Gly Gln Asp Arg Thr Asp Phe Phe Asp Val 
1               5                   10                  15  


<210>  117
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 11_GL VL

<400>  117

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His His Pro Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  118
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 11_GL LCDR1

<400>  118

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  119
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 11_GL LCDR2

<400>  119

Lys Ala Ser Thr Leu Glu Ser 
1               5           


<210>  120
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 11_GL LCDR3

<400>  120

Gln Gln Ser His His Pro Pro Trp Thr 
1               5                   


<210>  121
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 12_GL VH

<400>  121

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ala Asp 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Leu Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Gly Arg Val Thr Ile Ser Gly Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Pro Ala Tyr Phe Gly Gln Asp Arg Thr Asp Phe Phe 
            100                 105                 110         


Asp Val Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  122
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 12_GL HCDR1

<400>  122

Ala Asp Gly Tyr Tyr Trp Ser 
1               5           


<210>  123
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 12_GL HCDR2

<400>  123

Ser Leu Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Gly 
1               5                   10                  15      


<210>  124
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 12_GL HCDR3

<400>  124

Thr Pro Ala Tyr Phe Gly Gln Asp Arg Thr Asp Phe Phe Asp Val 
1               5                   10                  15  


<210>  125
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 12_GL VL

<400>  125

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His His Pro Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  126
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 12_GL LCDR1

<400>  126

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  127
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 12_GL LCDR2

<400>  127

Lys Ala Ser Thr Leu Glu Ser 
1               5           


<210>  128
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Antibody 12_GL LCDR3

<400>  128

Gln Gln Ser His His Pro Pro Trp Thr 
1               5                   


<210>  129
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR1

<400>  129

Gly Tyr Tyr Phe His 
1               5   


<210>  130
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR2

<400>  130

Arg Ile Asp Pro Glu Asp Asp Ser Thr Lys Tyr Ala Glu Arg Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  131
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HCDR3

<400>  131

Trp Arg Ile Tyr Arg Asp Ser Ser Gly Arg Pro Phe Tyr Val Met Asp 
1               5                   10                  15      


Ala 
    


<210>  132
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR1

<400>  132

Leu Ala Ser Glu Asp Ile Tyr Thr Tyr Leu Thr 
1               5                   10      


<210>  133
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR2

<400>  133

Gly Ala Asn Lys Leu Gln Asp 
1               5           


<210>  134
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LCDR3

<400>  134

Leu Gln Gly Ser Lys Phe Pro Leu Thr 
1               5                   


<210>  135
<211>  193
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human IL-18

<400>  135

Met Ala Ala Glu Pro Val Glu Asp Asn Cys Ile Asn Phe Val Ala Met 
1               5                   10                  15      


Lys Phe Ile Asp Asn Thr Leu Tyr Phe Ile Ala Glu Asp Asp Glu Asn 
            20                  25                  30          


Leu Glu Ser Asp Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile 
        35                  40                  45              


Arg Asn Leu Asn Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro 
    50                  55                  60                  


Leu Phe Glu Asp Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg 
65                  70                  75                  80  


Thr Ile Phe Ile Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met 
                85                  90                  95      


Ala Val Thr Ile Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys 
            100                 105                 110         


Glu Asn Lys Ile Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile 
        115                 120                 125             


Lys Asp Thr Lys Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly 
    130                 135                 140                 


His Asp Asn Lys Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe 
145                 150                 155                 160 


Leu Ala Cys Glu Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys 
                165                 170                 175     


Glu Asp Glu Leu Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu 
            180                 185                 190         


Asp 
    


<210>  136
<211>  582
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human IL-18 (PN)

<400>  136
atggctgctg aaccagtaga agacaattgc atcaactttg tggcaatgaa atttattgac       60

aatacgcttt actttatagc tgaagatgat gaaaacctgg aatcagatta ctttggcaag      120

cttgaatcta aattatcagt cataagaaat ttgaatgacc aagttctctt cattgaccaa      180

ggaaatcggc ctctatttga agatatgact gattctgact gtagagataa tgcaccccgg      240

accatattta ttataagtat gtataaagat agccagccta gaggtatggc tgtaactatc      300

tctgtgaagt gtgagaaaat ttcaactctc tcctgtgaga acaaaattat ttcctttaag      360

gaaatgaatc ctcctgataa catcaaggat acaaaaagtg acatcatatt ctttcagaga      420

agtgtcccag gacatgataa taagatgcaa tttgaatctt catcatacga aggatacttt      480

ctagcttgtg aaaaagagag agaccttttt aaactcattt tgaaaaaaga ggatgaattg      540

ggggatagat ctataatgtt cactgttcaa aacgaagact ag                         582


<210>  137
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: H1 heavy chain

<400>  137

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Glu Ile Ser Thr Gly Tyr 
            20                  25                  30          


Tyr Phe His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Asp Asp Ser Thr Lys Tyr Ala Glu Arg Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Trp Arg Ile Tyr Arg Asp Ser Ser Gly Arg Pro Phe Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210>  138
<211>  1370
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: H1 heavy chain (PN)

<400>  138
aggtgcagct ggtgcagagc ggagccgagg tgaagaagcc tggcgccagc gtcaaggtgt       60

cctgtaaggt gtccggcgag atcagcaccg gctactactt ccactgggtg aggcaggccc      120

ctggcaaggg cctggagtgg atgggcagaa tcgaccccga ggacgacagc accaagtacg      180

ccgagcggtt caaggacagg gtgaccatga ccgaggacac cagcaccgat accgcctaca      240

tggagctgtc cagcctgaga agcgaggata ccgccgtgta ctactgtacc acctggcgga      300

tctacagaga cagcagcggc agacccttct acgtgatgga tgcctggggc cagggcacac      360

tagtgaccgt gtccagcgcc agcaccaagg gccccagcgt gttccccctg gcccccagca      420

gcaagagcac cagcggcggc acagccgccc tgggctgcct ggtgaaggac tacttccccg      480

aaccggtgac cgtgtcctgg aacagcggag ccctgaccag cggcgtgcac accttccccg      540

ccgtgctgca gagcagcggc ctgtacagcc tgagcagcgt ggtgaccgtg cccagcagca      600

gcctgggcac ccagacctac atctgtaacg tgaaccacaa gcccagcaac accaaggtgg      660

acaagaaggt ggagcccaag agctgtgaca agacccacac ctgccccccc tgccctgccc      720

ccgagctgct gggaggcccc agcgtgttcc tgttcccccc caagcctaag gacaccctga      780

tgatcagcag aacccccgag gtgacctgtg tggtggtgga tgtgagccac gaggaccctg      840

aggtgaagtt caactggtac gtggacggcg tggaggtgca caatgccaag accaagccca      900

gggaggagca gtacaacagc acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg      960

attggctgaa cggcaaggag tacaagtgta aggtgtccaa caaggccctg cctgccccta     1020

tcgagaaaac catcagcaag gccaagggcc agcccagaga gccccaggtg tacaccctgc     1080

cccctagcag agatgagctg accaagaacc aggtgtccct gacctgcctg gtgaagggct     1140

tctaccccag cgacatcgcc gtggagtggg agagcaacgg ccagcccgag aacaactaca     1200

agaccacccc ccctgtgctg gacagcgatg gcagcttctt cctgtacagc aagctgaccg     1260

tggacaagag cagatggcag cagggcaacg tgttcagctg ctccgtgatg cacgaggccc     1320

tgcacaatca ctacacccag aagagcctga gcctgtcccc tggcaagtga                1370


<210>  139
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: H1 variable region

<400>  139

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Glu Ile Ser Thr Gly Tyr 
            20                  25                  30          


Tyr Phe His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Asp Asp Ser Thr Lys Tyr Ala Glu Arg Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Trp Arg Ile Tyr Arg Asp Ser Ser Gly Arg Pro Phe Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  140
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: H1 variable region (PN)

<400>  140
caggtgcagc tggtgcagag cggagccgag gtgaagaagc ctggcgccag cgtcaaggtg       60

tcctgtaagg tgtccggcga gatcagcacc ggctactact tccactgggt gaggcaggcc      120

cctggcaagg gcctggagtg gatgggcaga atcgaccccg aggacgacag caccaagtac      180

gccgagcggt tcaaggacag ggtgaccatg accgaggaca ccagcaccga taccgcctac      240

atggagctgt ccagcctgag aagcgaggat accgccgtgt actactgtac cacctggcgg      300

atctacagag acagcagcgg cagacccttc tacgtgatgg atgcctgggg ccagggcaca      360

ctagtgaccg tgtccagc                                                    378


<210>  141
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: L2 light chain

<400>  141

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Asp Ile Tyr Thr Tyr 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Asn Lys Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Gly Ser Lys Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  142
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: L2 light chain (PN)

<400>  142
gatatccaga tgacccagtc ccccagcagc gtgtccgcct ctgtgggcga tagagtgacc       60

atcacctgcc tggccagcga ggacatctac acctacctga cctggtatca gcagaagcct      120

ggcaaggccc ctaagctgct gatctacggc gccaacaagc tgcaggacgg cgtgcccagc      180

agattcagcg gcagcggctc cggcaccgac tacaccctga ccatcagcag cctgcagcct      240

gaggatttcg ccacctacta ctgcctgcag ggcagcaagt tccccctgac cttcggccag      300

ggcaccaagc tggagatcaa gcgtacggtg gccgccccca gcgtgttcat cttccccccc      360

agcgatgagc agctgaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac      420

ccccgggagg ccaaggtgca gtggaaggtg gacaatgccc tgcagagcgg caacagccag      480

gagagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gc                         642


<210>  143
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: L2 variable region

<400>  143

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Asp Ile Tyr Thr Tyr 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Asn Lys Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Gly Ser Lys Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  144
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: L2 variable region (PN)

<400>  144
gatatccaga tgacccagtc ccccagcagc gtgtccgcct ctgtgggcga tagagtgacc       60

atcacctgcc tggccagcga ggacatctac acctacctga cctggtatca gcagaagcct      120

ggcaaggccc ctaagctgct gatctacggc gccaacaagc tgcaggacgg cgtgcccagc      180

agattcagcg gcagcggctc cggcaccgac tacaccctga ccatcagcag cctgcagcct      240

gaggatttcg ccacctacta ctgcctgcag ggcagcaagt tccccctgac cttcggccag      300

ggcaccaagc tggagatcaa g                                                321


<210>  145
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: H2 heavy chain

<400>  145

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Glu Ile Ser Thr Gly Tyr 
            20                  25                  30          


Tyr Phe His Trp Val Arg Arg Arg Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Asp Asp Ser Thr Lys Tyr Ala Glu Arg Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Trp Arg Ile Tyr Arg Asp Ser Ser Gly Arg Pro Phe Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210>  146
<211>  1368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: H2 heavy chain (PN)

<400>  146
caggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg tttccggaga aataagtact ggatactatt tccactgggt gcgacgaagg      120

cctggaaaag ggcttgagtg gatgggaagg attgatcctg aggatgatag tactaaatat      180

gctgagaggt tcaaagacag agtcaccatg accgaggaca catctacaga cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtac cacatggcgg      300

atataccgag atagttctgg ccgccccttc tatgttatgg atgcctgggg ccaagggaca      360

ctagtcacag tctcctcagc ctccaccaag ggcccatcgg tcttccccct ggcaccctcc      420

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      480

gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      540

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      600

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      660

gacaagaaag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      720

cctgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      780

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      840

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      900

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag      960

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc     1020

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1080

cccccatccc gggatgagct gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1140

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1200

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc     1260

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1320

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaa                  1368


<210>  147
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: H2 variable region

<400>  147

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Glu Ile Ser Thr Gly Tyr 
            20                  25                  30          


Tyr Phe His Trp Val Arg Arg Arg Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Asp Asp Ser Thr Lys Tyr Ala Glu Arg Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Trp Arg Ile Tyr Arg Asp Ser Ser Gly Arg Pro Phe Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  148
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: H2 variable region (PN)

<400>  148
caggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg tttccggaga aataagtact ggatactatt tccactgggt gcgacgaagg      120

cctggaaaag ggcttgagtg gatgggaagg attgatcctg aggatgatag tactaaatat      180

gctgagaggt tcaaagacag agtcaccatg accgaggaca catctacaga cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtac cacatggcgg      300

atataccgag atagttctgg ccgccccttc tatgttatgg atgcctgggg ccaagggaca      360

ctagtcacag tctcctca                                                    378


<210>  149
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: H3 heavy chain

<400>  149

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Glu Ile Ser Thr Gly Tyr 
            20                  25                  30          


Tyr Phe His Phe Val Arg Arg Arg Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Asp Asp Ser Thr Lys Tyr Ala Glu Arg Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Thr Thr Trp Arg Ile Tyr Arg Asp Ser Ser Gly Arg Pro Phe Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210>  150
<211>  1368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: H3 heavy chain (PN)

<400>  150
caggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg tttccggaga aataagtact ggatactatt tccactttgt gcgacgaagg      120

cctggaaaag ggcttgagtg gatgggaagg attgatcctg aggatgatag tactaaatat      180

gctgagaggt tcaaagacag agtcaccatg accgcagaca catctacaga cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccactt atttttgtac cacatggcgg      300

atataccgag atagttctgg ccgccccttc tatgttatgg atgcctgggg ccaagggaca      360

ctagtcacag tctcctcagc ctccaccaag ggcccatcgg tcttccccct ggcaccctcc      420

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      480

gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      540

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      600

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      660

gacaagaaag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      720

cctgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      780

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      840

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      900

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag      960

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc     1020

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1080

cccccatccc gggatgagct gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1140

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1200

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc     1260

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1320

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaa                  1368


<210>  151
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: H3 variable region

<400>  151

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Glu Ile Ser Thr Gly Tyr 
            20                  25                  30          


Tyr Phe His Phe Val Arg Arg Arg Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Asp Asp Ser Thr Lys Tyr Ala Glu Arg Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Thr Thr Trp Arg Ile Tyr Arg Asp Ser Ser Gly Arg Pro Phe Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  152
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: H3 variable region (PN)

<400>  152
caggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg tttccggaga aataagtact ggatactatt tccactttgt gcgacgaagg      120

cctggaaaag ggcttgagtg gatgggaagg attgatcctg aggatgatag tactaaatat      180

gctgagaggt tcaaagacag agtcaccatg accgcagaca catctacaga cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccactt atttttgtac cacatggcgg      300

atataccgag atagttctgg ccgccccttc tatgttatgg atgcctgggg ccaagggaca      360

ctagtcacag tctcctca                                                    378


<210>  153
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: L1 light chain

<400>  153

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Asp Ile Tyr Thr Tyr 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Asn Lys Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Gly Ser Lys Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  154
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: L1 light chain (PN)

<400>  154
gacatccaga tgacccagtc tccatcttct gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc tggcaagtga ggacatatac acttatttaa catggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatggt gcaaataagt tgcaagatgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ctatcagcag cctgcagcct      240

gaagattttg caacttacta ttgtctacag ggttccaagt ttccgctcac gtttggccag      300

gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gacaacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  155
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: L1 variable region

<400>  155

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Asp Ile Tyr Thr Tyr 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Asn Lys Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Gly Ser Lys Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  156
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: L1 variable region (PN)

<400>  156
gacatccaga tgacccagtc tccatcttct gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc tggcaagtga ggacatatac acttatttaa catggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatggt gcaaataagt tgcaagatgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ctatcagcag cctgcagcct      240

gaagattttg caacttacta ttgtctacag ggttccaagt ttccgctcac gtttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  157
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: L3 light chain

<400>  157

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Asp Ile Tyr Thr Tyr 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Asn Lys Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Glu Gly Asp Tyr Tyr Cys Leu Gln Gly Ser Lys Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  158
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: L3 light chain (PN)

<400>  158
gacatccaga tgacccagtc tccatcttct gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc tggcaagtga ggacatatac acttatttaa catggtatca gcagaaacca      120

gggaaagccc ctcaactcct gatctatggt gcaaataagt tgcaagatgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat tatactctca ctatcagcag cctgcagcct      240

gaagatgaag gggattacta ttgtctacag ggttccaagt ttccgctcac gtttggccag      300

gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gacaacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                      645


<210>  159
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: L3 variable region

<400>  159

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Asp Ile Tyr Thr Tyr 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Asn Lys Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Glu Gly Asp Tyr Tyr Cys Leu Gln Gly Ser Lys Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  160
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: L3 variable region (PN)

<400>  160
gacatccaga tgacccagtc tccatcttct gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc tggcaagtga ggacatatac acttatttaa catggtatca gcagaaacca      120

gggaaagccc ctcaactcct gatctatggt gcaaataagt tgcaagatgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat tatactctca ctatcagcag cctgcagcct      240

gaagatgaag gggattacta ttgtctacag ggttccaagt ttccgctcac gtttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  161
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 2c10 rat-human IgG1 chimera

<400>  161

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Val Ser Gly Glu Ile Ser Thr Gly Tyr 
            20                  25                  30          


Tyr Phe His Phe Val Arg Arg Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Asp Asp Ser Thr Lys Tyr Ala Glu Arg Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Leu Thr Ala Gln Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Asn Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Thr Thr Trp Arg Ile Tyr Arg Asp Ser Ser Gly Arg Pro Phe Tyr Val 
            100                 105                 110         


Met Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210>  162
<211>  1368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 2c10 rat-human IgG1 chimera (PN)

<400>  162
gaggtccagc tacagcagtc tggggctgag cttgtgagac ctgggacctc tgtgaagtta       60

tcttgcaaag tttctggcga aataagtaca ggatactatt tccactttgt gaggcgaagg      120

cctggacagg gtctggaatg gataggaagg attgatcctg aggatgatag tactaaatat      180

gctgagaggt tcaaagacag ggcgacgctc actgcacaaa catcctccaa cacagcctac      240

ctgaacctca gcagcctgac ctctgaggac actgcaactt atttttgtac cacatggcgg      300

atataccgag atagttctgg ccgccccttc tatgttatgg atgcctgggg tcaaggaaca      360

ctagtcacag tctcctcagc ctccaccaag ggcccatcgg tcttccccct ggcaccctcc      420

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      480

gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      540

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      600

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      660

gacaagaaag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      720

cctgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      780

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      840

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      900

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag      960

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc     1020

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1080

cccccatccc gggatgagct gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1140

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1200

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc     1260

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1320

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaa                  1368


<210>  163
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 2c10 rat-human CKappa chimera

<400>  163

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Thr Val Ser Ile Glu Cys Leu Ala Ser Glu Asp Ile Tyr Thr Tyr 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Asn Lys Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Ser Gly Ile Gln Pro 
65                  70                  75                  80  


Glu Asp Glu Gly Asp Tyr Phe Cys Leu Gln Gly Ser Lys Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  164
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 2c10 rat-human CKappa chimera (PN)

<400>  164
gacattcaaa tgacccagtc tccagcttcc ctgtctgcat ctctgggaga aactgtctcc       60

atcgaatgtc tggcaagtga ggacatatac acttatttaa catggtatca gcagaaacca      120

gggaaatctc ctcaactcct gatctatggt gcaaataagt tgcaagatgg ggtcccatca      180

cggttcagtg gcagtggatc tggcacacag tattctctca agatcagcgg catacaacct      240

gaagatgaag gggattattt ctgtctacag ggttccaagt ttccgctcac gttcggttct      300

gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gacaacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  165
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Heavy chain acceptor framework

<400>  165

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr 
        


<210>  166
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Light chain acceptor framework

<400>  166

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro 
                85                  90                  95  


<210>  167
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: JH6 amino acid sequence added to SEQ ID NO: 37

<400>  167

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  168
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Jkappa 2 amino acid sequence added to SEQ ID NO: 38

<400>  168

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


