                         SEQUENCE LISTING

<110>  INSERM (Institut National de la Sant et de la Recherche 
       Mdicale)
       Universit de Paris
       Universit  Paris 13 Paris Nord
 
<120>  Biomimetic coating for endovascular stent

<130>  @E0136148

<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intermediate A

<400>  1

Gln His Gln Met Leu Phe Tyr His Cys Asp Asp Val Leu Phe Tyr Asn 
1               5                   10                  15      


Ile Ser Ser Met Lys 
            20      


<210>  2
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intermediate B

<400>  2

Gly Thr Tyr Lys Ser Thr Val Ile Val Asn Asn Lys Glu Lys Thr Thr 
1               5                   10                  15      


Ala Glu Tyr Gln 
            20  


<210>  3
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intermediate C

<400>  3

Pro Arg Val Thr Leu Asp Lys Lys Glu Ala Ile Gln Gly Gly Ile Val 
1               5                   10                  15      


Arg Val Asn Ser Ser Val Pro Glu Glu Lys 
            20                  25      


<210>  4
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Structure IA

<400>  4

His Gln Met Leu Phe Tyr Lys Asp Asp Val Leu Phe Tyr Asn Ile Ser 
1               5                   10                  15      


Ser 
    


<210>  5
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Structure IB

<400>  5

Tyr Lys Ser Thr Val Ile Val Asn Asn Lys Glu Lys Thr Thr Ala Glu 
1               5                   10                  15      


<210>  6
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Structure IC

<400>  6

Pro Arg Val Thr Leu Asp Lys Lys Glu Ala Ile Gln Gly Gly Ile Val 
1               5                   10                  15      


Arg Val Asn Ser Ser Val Pro Glu Glu Lys 
            20                  25      


<210>  7
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sub-structure IA

<400>  7

His Gln Met Leu Phe Tyr Lys Asp Asp Val Leu Phe Tyr Asn Ile Ser 
1               5                   10                  15      


Ser Cys 
        


<210>  8
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sub-structure IA

<400>  8

Ser His Gln Met Leu Phe Tyr Lys Asp Asp Val Leu Phe Tyr Asn Ile 
1               5                   10                  15      


Ser Ser Ser 
            


<210>  9
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sub-structure IA

<400>  9

Gln His Gln Met Leu Phe Tyr Lys Asp Asp Val Leu Phe Tyr Asn Ile 
1               5                   10                  15      


Ser Ser Met Lys 
            20  


<210>  10
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sub-structure IA

<400>  10

Cys His Gln Met Leu Phe Tyr Lys Asp Asp Val Leu Phe Tyr Asn Ile 
1               5                   10                  15      


Ser Ser Cys Lys 
            20  


<210>  11
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sub-structure IA

<400>  11

Tyr Lys Asp Asp Val Leu Phe Tyr Asn Ile Ser Ser Met Lys Ser Thr 
1               5                   10                  15      


<210>  12
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sub-structure IA

<400>  12

Pro Gln His Gln Met Leu Phe Tyr Lys Asp Asp Val Leu Phe Tyr Asn 
1               5                   10                  15      


Ile Ser Ser Met Lys 
            20      


<210>  13
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sub-structure IA

<400>  13

Phe Ala Asp Val Ser Thr Thr Ser His Val Lys Pro Gln His Gln Met 
1               5                   10                  15      


Leu Phe Tyr Lys Asp Asp Val Leu Phe Tyr Asn Ile Ser Ser Met Lys 
            20                  25                  30          


Ser Thr Glu Ser Tyr Phe Ile Pro Glu Val Arg Ile Tyr Asp Ser Gly 
        35                  40                  45              


Thr Tyr Lys 
    50      


<210>  14
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sub-structure IA

<400>  14

Pro Gln His Gln Met Leu Phe Tyr Lys Asp Asp Val Leu Phe Tyr Asn 
1               5                   10                  15      


Ile Ser Ser Met Lys Ser Thr Glu Ser Tyr Phe Ile Pro Glu Val Arg 
            20                  25                  30          


Ile Tyr Asp Ser Gly Thr Tyr Lys Ser Thr Val 
        35                  40              


<210>  15
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sub-structure IA

<400>  15

Tyr Lys Asp Asp Val Leu Phe Tyr Asn Ile Ser Ser Met Lys Ser Thr 
1               5                   10                  15      


Glu Ser Tyr Phe Ile Pro Glu Val Arg Ile Tyr Asp Ser Gly Thr Tyr 
            20                  25                  30          


Lys Ser Thr Val 
        35      


<210>  16
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sub-structure IA

<400>  16

His Gln Met Leu Phe Tyr Lys Asp Asp Val Leu Phe Tyr Asn Ile Ser 
1               5                   10                  15      


Ser Met Lys Ser Thr Glu Ser Tyr Phe Ile Pro Glu Val Arg Ile Tyr 
            20                  25                  30          


Asp Ser Gly Thr Tyr Lys Ser Thr Val 
        35                  40      


<210>  17
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sub-structure IA

<400>  17

Leu Phe Tyr Lys Asp Asp Val Leu Phe Tyr Asn Ile Ser Ser Met Lys 
1               5                   10                  15      


Ser Thr Glu Ser Tyr Phe 
            20          


<210>  18
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sub-structure IA

<400>  18

Pro Gln His Gln Met Leu Phe Tyr Lys Asp Asp Val Leu Phe Tyr Asn 
1               5                   10                  15      


Ile Ser Ser Met Lys 
            20      


<210>  19
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sub-structure IB

<400>  19

Tyr Lys Ser Thr Val Ile Val Asn Asn Lys Glu Lys Thr Thr Ala Glu 
1               5                   10                  15      


<210>  20
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sub-structure IB

<400>  20

Asp Asp Val Leu Phe Tyr Asn Ile Ser Ser Met Lys 
1               5                   10          


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sub-structure IB

<400>  21

Gln His Gln Met Leu Phe Tyr 
1               5           


<210>  22
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sub-structure IB

<400>  22

Cys Tyr Lys Ser Thr Val Ile Val Asn Asn Lys Glu Lys Thr Thr Ala 
1               5                   10                  15      


Glu Tyr Cys 
            


<210>  23
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sub-structure IB


<220>
<221>  DISULFID
<222>  (1)..(19)

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Cys is homocysteine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Cys is homocysteine

<400>  23

Cys Tyr Lys Ser Thr Val Ile Val Asn Asn Lys Glu Lys Thr Thr Ala 
1               5                   10                  15      


Glu Tyr Cys 
            


<210>  24
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sub-strucure IB

<400>  24

Gly Thr Tyr Lys Ser Thr Val Ile Val Asn Asn Lys Glu Lys Thr Thr 
1               5                   10                  15      


Ala Glu Tyr Gln 
            20  


<210>  25
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sub-structure IC

<400>  25

Pro Arg Cys Thr Leu Asp Lys Lys Glu Ala Ile Gln Gly Gly Ile Val 
1               5                   10                  15      


Arg Val Asn Cys Ser Val Pro Glu Glu Lys 
            20                  25      


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  -

<400>  26

Arg Asp Gln Asn Phe Val Ile Leu Glu Phe Pro 
1               5                   10      


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spacer or linker

<400>  27

Gly Gly Ser Gly Gly Ser Gly Gly 
1               5               


<210>  28
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intermediate A


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  cysteine is homocysteine

<400>  28

Gln His Gln Met Leu Phe Tyr Cys Asp Asp Val Leu Phe Tyr Asn Ile 
1               5                   10                  15      


Ser Ser Met Lys 
            20  


<210>  29
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alternative SEQ. ID. no. 7


<220>
<221>  DISULFID
<222>  (1)..(19)

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D amino acid

<220>
<221>  BINDING
<222>  (19)..(19)
<223>  GGSGGSGG-K(N3)

<400>  29

Cys His Gln Met Leu Phe Tyr Lys Asp Asp Val Leu Phe Tyr Asn Ile 
1               5                   10                  15      


Ser Ser Cys 
            


<210>  30
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alternative SEQ. ID. 8


<220>
<221>  BINDING
<222>  (19)..(19)
<223>  GGSGGSGG

<220>
<221>  BINDING
<222>  (19)..(19)
<223>  GGSGGSGG-K(N3)

<400>  30

Ser His Gln Met Leu Phe Tyr Lys Asp Asp Val Leu Phe Tyr Asn Ile 
1               5                   10                  15      


Ser Ser Ser 
            


<210>  31
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alternative SEQ. ID no. 7


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-cysteine

<220>
<221>  DISULFID
<222>  (1)..(19)

<220>
<221>  BINDING
<222>  (1)..(1)
<223>  KKK

<220>
<221>  BINDING
<222>  (19)..(19)
<223>  (Ttds)2-K(N3)

<400>  31

Cys His Gln Met Leu Phe Tyr Lys Asp Asp Val Leu Phe Tyr Asn Ile 
1               5                   10                  15      


Ser Ser Cys 
            


<210>  32
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alternative SEQ. ID no. 9


<220>
<221>  BINDING
<222>  (20)..(20)
<223>  (Ttds)4-K(N3)

<400>  32

Gln His Gln Met Leu Phe Tyr Lys Asp Asp Val Leu Phe Tyr Asn Ile 
1               5                   10                  15      


Ser Ser Met Lys 
            20  


<210>  33
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alternative SEQ. ID no. 10


<220>
<221>  DISULFID
<222>  (1)..(19)

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  cysteine is homosysteine

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  cysteine is homosysteine

<220>
<221>  BINDING
<222>  (20)..(20)
<223>  (Ttds)4-K(N3)

<400>  33

Cys His Gln Met Leu Phe Tyr Lys Asp Asp Val Leu Phe Tyr Asn Ile 
1               5                   10                  15      


Ser Ser Cys Lys 
            20  


<210>  34
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alternative SEQ. ID no. 19


<220>
<221>  BINDING
<222>  (16)..(16)
<223>  (PEG)4-K(N3)

<400>  34

Tyr Lys Ser Thr Val Ile Val Asn Asn Lys Glu Lys Thr Thr Ala Glu 
1               5                   10                  15      


<210>  35
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Structure IC


<220>
<221>  BINDING
<222>  (1)..(1)
<223>  K(N3)-(PEG)4

<400>  35

Pro Arg Val Thr Leu Asp Lys Lys Glu Ala Ile Gln Gly Gly Ile Val 
1               5                   10                  15      


Arg Val Asn Ser Ser Val Pro Glu Glu Lys 
            20                  25      


<210>  36
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alternative Structure IC


<220>
<221>  BINDING
<222>  (1)..(1)
<223>  K(N3)-(Ttds)4

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  cysteine is homocysteine

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  cysteine is homocysteine

<400>  36

Pro Arg Cys Thr Leu Asp Lys Lys Glu Ala Ile Gln Gly Gly Ile Val 
1               5                   10                  15      


Arg Val Asn Cys Ser Val Pro Glu Glu Lys 
            20                  25      


<210>  37
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sub-structure IB


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  glycine is linked to acetamide which is a site for acetyl 
       thioether linkage to aspartic acid at postiion 35

<220>
<221>  NON_CONS
<222>  (20)..(21)

<220>
<221>  BINDING
<222>  (20)..(20)
<223>  -(Ttds)4-K(N3)-NH2

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  cysteine is homocysteine

<220>
<221>  THIOETH
<222>  (29)..(29)
<223>  acetyl thioether linkage to acetamido group linked to glycine in 
       position 1

<400>  37

Gly Thr Tyr Lys Ser Thr Val Ile Val Asn Asn Lys Glu Lys Thr Thr 
1               5                   10                  15      


Ala Glu Tyr Gln Gln His Gln Met Leu Phe Tyr Cys Asp Asp Val Leu 
            20                  25                  30          


Phe Tyr Asn Ile Ser Ser Met Lys 
        35                  40  


<210>  38
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  -


<220>
<221>  BINDING
<222>  (1)..(1)
<223>  K(N3)-(Ttds)4

<220>
<221>  NON_CONS
<222>  (26)..(27)

<220>
<221>  BINDING
<222>  (26)..(26)
<223>  -Ttds-K (CH2CO)-CONH2- wherein lysine is a site for acetyl 
       thioether linkage to aspartic acid at position 35

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  cysteine is homocysteine

<220>
<221>  THIOETH
<222>  (35)..(35)

<400>  38

Pro Arg Val Thr Leu Asp Lys Lys Glu Ala Ile Gln Gly Gly Ile Val 
1               5                   10                  15      


Arg Val Asn Ser Ser Val Pro Glu Glu Lys Gln His Gln Met Leu Phe 
            20                  25                  30          


Tyr Cys Asp Asp Val Leu Phe Tyr Asn Ile Ser Ser Met Lys 
        35                  40                  45      


<210>  39
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alternative  SEQ. ID no. 11


<220>
<221>  BINDING
<222>  (1)..(1)
<223>  K(N3)-GGSGGSGG

<400>  39

Tyr Lys Asp Asp Val Leu Phe Tyr Asn Ile Ser Ser Met Lys Ser Thr 
1               5                   10                  15      


<210>  40
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alternative SEQ. ID no. 11


<220>
<221>  BINDING
<222>  (16)..(16)
<223>  GGSGGSGG- K(N3)

<400>  40

Tyr Lys Asp Asp Val Leu Phe Tyr Asn Ile Ser Ser Met Lys Ser Thr 
1               5                   10                  15      


<210>  41
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alternative SEQ. ID no. 12


<220>
<221>  BINDING
<222>  (21)..(21)
<223>  GGSGGSGG-K(N3) linked to the amino tail of lysin

<400>  41

Pro Gln His Gln Met Leu Phe Tyr Lys Asp Asp Val Leu Phe Tyr Asn 
1               5                   10                  15      


Ile Ser Ser Met Lys Ser Thr Glu Ser Tyr Phe Ile 
            20                  25              


<210>  42
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alternative SEQ. ID No. 13


<220>
<221>  BINDING
<222>  (1)..(1)
<223>  K(N3)-GGSGGSGG

<400>  42

Phe Ala Asp Val Ser Thr Thr Ser His Val Lys Pro Gln His Gln Met 
1               5                   10                  15      


Leu Phe Tyr Lys Asp Asp Val Leu Phe Tyr Asn Ile Ser Ser Met Lys 
            20                  25                  30          


Ser Thr Glu Ser Tyr Phe Ile Pro Glu Val Arg Ile Tyr Asp Ser Gly 
        35                  40                  45              


Thr Tyr Lys 
    50      


<210>  43
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alternative SEQ. ID no. 14


<220>
<221>  BINDING
<222>  (1)..(1)
<223>  K(N3)-GGSGGSGG

<400>  43

Pro Gln His Gln Met Leu Phe Tyr Lys Asp Asp Val Leu Phe Tyr Asn 
1               5                   10                  15      


Ile Ser Ser Met Lys Ser Thr Glu Ser Tyr Phe Ile Pro Glu Val Arg 
            20                  25                  30          


Ile Tyr Asp Ser Gly Thr Tyr Lys Ser Thr Val 
        35                  40              


<210>  44
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alternative SEQ. ID no. 15


<220>
<221>  BINDING
<222>  (1)..(1)
<223>  K(N3)-GGSGGSGG-

<400>  44

Tyr Lys Asp Asp Val Leu Phe Tyr Asn Ile Ser Ser Met Lys Ser Thr 
1               5                   10                  15      


Glu Ser Tyr Phe Ile Pro Glu Val Arg Ile Tyr Asp Ser Gly Thr Tyr 
            20                  25                  30          


Lys Ser Thr Val 
        35      


<210>  45
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alternative SEQ. ID no. 16


<220>
<221>  BINDING
<222>  (1)..(1)
<223>  K(N3)-GGSGGSGG

<400>  45

His Gln Met Leu Phe Tyr Lys Asp Asp Val Leu Phe Tyr Asn Ile Ser 
1               5                   10                  15      


Ser Met Lys Ser Thr Glu Ser Tyr Phe Ile Pro Glu Val Arg Ile Tyr 
            20                  25                  30          


Asp Ser Gly Thr Tyr Lys Ser Thr Val 
        35                  40      


<210>  46
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alternative SEQ. ID no. 17


<220>
<221>  BINDING
<222>  (22)..(22)
<223>  GGSGGSGG-K(N3)

<400>  46

Leu Phe Tyr Lys Asp Asp Val Leu Phe Tyr Asn Ile Ser Ser Met Lys 
1               5                   10                  15      


Ser Thr Glu Ser Tyr Phe 
            20          


<210>  47
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alternative SEQ. ID no. 17


<220>
<221>  BINDING
<222>  (22)..(22)
<223>  Ttds-Ttds-K(N3)

<400>  47

Leu Phe Tyr Lys Asp Asp Val Leu Phe Tyr Asn Ile Ser Ser Met Lys 
1               5                   10                  15      


Ser Thr Glu Ser Tyr Phe 
            20          


<210>  48
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alternative SEQ. ID no. 18


<220>
<221>  BINDING
<222>  (21)..(21)
<223>  GGSGGSGG-K(N3) linked to the amino tail of lysin

<400>  48

Pro Gln His Gln Met Leu Phe Tyr Lys Asp Asp Val Leu Phe Tyr Asn 
1               5                   10                  15      


Ile Ser Ser Met Lys Ser Thr Glu Ser Tyr Phe Ile Lys Lys 
            20                  25                  30  


<210>  49
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alternative SEQ. ID no. 26


<220>
<221>  BINDING
<222>  (11)..(11)
<223>  PEG4-K(N3)-

<400>  49

Arg Asp Gln Asn Phe Val Ile Leu Glu Phe Pro 
1               5                   10      


