SEQUENCE LISTING

<110>  Linno Pharmaceuticals Inc.

<120>  VEGF-Binding Protein and Use Thereof

<130>  0231-PA-002

<160>  38

<170>  PatentIn version 3.5

<210>  1
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLN-6068(C2-11) CDR3

<400>  1

Arg Met Ser Arg Leu Leu Gly Met Ala Pro Leu Leu Pro Glu His Tyr 
1               5                   10                  15      


Asp Ser 
        


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLN-6068(C2-11) CDR2

<400>  2

Ala Ala Tyr Ala Gly Gly Gly Gly Thr Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLN-6068(C2-11) CDR1

<400>  3

Val Tyr Thr Ser Ser Thr Tyr Tyr Met Ala 
1               5                   10  


<210>  4
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLN-6043 (F6-1) CDR3

<400>  4

Lys Trp Pro Cys Thr Tyr Arg Arg Gly Gly Ser Ala Tyr Arg Pro Ala 
1               5                   10                  15      


Val Val 
        


<210>  5
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLN-6043 (F6-1) CDR2

<400>  5

Ser Ile Ser Ser Asp Asp Ser Thr Arg Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLN-6043 (F6-1) CDR1

<400>  6

Gly Phe Thr Ser Asp Asn Cys Ala Val His 
1               5                   10  


<210>  7
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLN-6062 (C8-9) CDR3

<400>  7

Thr Trp Ser Trp Tyr Ser Phe Thr Cys Pro Gly Asp Gln Asn Ala Tyr 
1               5                   10                  15      


Ile His 
        


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLN-6062 (C8-9) CDR2

<400>  8

Thr Leu Asn Arg Asn Ser Gly Arg Thr Ser Tyr Val Gly Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLN-6062 (C8-9) CDR1

<400>  9

Val Tyr Thr Ala Ser Cys Met Gly 
1               5               


<210>  10
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLN-6065 (D2-9) CDR3

<400>  10

Gly Trp Arg Gly Gly Ser Phe Trp Thr Pro Ser Lys Tyr Ser Tyr 
1               5                   10                  15  


<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLN-6065 (D2-9) CDR2

<400>  11

Ser Ile Ala Thr Asn Thr Gly Asn Asp Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLN-6065 (D2-9) CDR1

<400>  12

Arg Asp Ala Tyr Phe Asn Asn Tyr Met Ala 
1               5                   10  


<210>  13
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLN-6068(C2-11)

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Tyr Thr Ser Ser Thr Tyr 
            20                  25                  30          


Tyr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ala Tyr Ala Gly Gly Gly Gly Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Met Ser Arg Leu Leu Gly Met Ala Pro Leu Leu Pro Glu 
            100                 105                 110         


His Tyr Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  14
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLN-6043 (F6-1)

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Asp Asn Cys 
            20                  25                  30          


Ala Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Asp Asp Ser Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys Gln 
                85                  90                  95      


Thr Lys Trp Pro Cys Thr Tyr Arg Arg Gly Gly Ser Ala Tyr Arg Pro 
            100                 105                 110         


Ala Val Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  15
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLN-6062 (C8-9)

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Tyr Thr Ala Ser Cys Met 
            20                  25                  30          


Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val Ser Thr 
        35                  40                  45              


Leu Asn Arg Asn Ser Gly Arg Thr Ser Tyr Val Gly Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Lys Thr Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
                85                  90                  95      


Thr Trp Ser Trp Tyr Ser Phe Thr Cys Pro Gly Asp Gln Asn Ala Tyr 
            100                 105                 110         


Ile His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  16
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLN-6065 (D2-9)

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Asp Ala Tyr Phe Asn Asn 
            20                  25                  30          


Tyr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Ala Thr Asn Thr Gly Asn Asp Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ile Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Trp Arg Gly Gly Ser Phe Trp Thr Pro Ser Lys Tyr Ser 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  17
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SLN6071, bi-paratopic VHH-1)C2_F6

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Tyr Thr Ser Ser Thr Tyr 
            20                  25                  30          


Tyr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ala Tyr Ala Gly Gly Gly Gly Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Met Ser Arg Leu Leu Gly Met Ala Pro Leu Leu Pro Glu 
            100                 105                 110         


His Tyr Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    130                 135                 140                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Asp Asn Cys Ala Val 
                165                 170                 175     


His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            180                 185                 190         


Ile Ser Ser Asp Asp Ser Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg 
        195                 200                 205             


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr Leu Gln Met 
    210                 215                 220                 


Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys Gln Thr Lys 
225                 230                 235                 240 


Trp Pro Cys Thr Tyr Arg Arg Gly Gly Ser Ala Tyr Arg Pro Ala Val 
                245                 250                 255     


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265             


<210>  18
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SLN6075, , bi-paratopic VHH-2)C2_C8

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Tyr Thr Ser Ser Thr Tyr 
            20                  25                  30          


Tyr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ala Tyr Ala Gly Gly Gly Gly Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Met Ser Arg Leu Leu Gly Met Ala Pro Leu Leu Pro Glu 
            100                 105                 110         


His Tyr Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    130                 135                 140                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Ala Ala Ser Val Tyr Thr Ala Ser Cys Met Gly Trp 
                165                 170                 175     


Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val Ser Thr Leu Asn 
            180                 185                 190         


Arg Asn Ser Gly Arg Thr Ser Tyr Val Gly Ser Val Lys Gly Arg Phe 
        195                 200                 205             


Thr Ile Ser Gln Asp Asn Ser Lys Lys Thr Leu Tyr Leu Gln Met Asn 
    210                 215                 220                 


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Thr Trp 
225                 230                 235                 240 


Ser Trp Tyr Ser Phe Thr Cys Pro Gly Asp Gln Asn Ala Tyr Ile His 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265         


<210>  19
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SLN6079, bi-paratopic VHH-3)C2_D2

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Tyr Thr Ser Ser Thr Tyr 
            20                  25                  30          


Tyr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ala Tyr Ala Gly Gly Gly Gly Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Met Ser Arg Leu Leu Gly Met Ala Pro Leu Leu Pro Glu 
            100                 105                 110         


His Tyr Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    130                 135                 140                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Ala Ala Ser Arg Asp Ala Tyr Phe Asn Asn Tyr Met 
                165                 170                 175     


Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val Ser Ser 
            180                 185                 190         


Ile Ala Thr Asn Thr Gly Asn Asp Tyr Tyr Ala Asp Ser Val Lys Gly 
        195                 200                 205             


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ile Tyr Leu Gln 
    210                 215                 220                 


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
225                 230                 235                 240 


Gly Trp Arg Gly Gly Ser Phe Trp Thr Pro Ser Lys Tyr Ser Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265     


<210>  20
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc region

<400>  20

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  21
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SLN6073, C2_D2-Fc fusion)

<400>  21

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Tyr Thr Ser Ser Thr Tyr 
            20                  25                  30          


Tyr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ala Tyr Ala Gly Gly Gly Gly Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Met Ser Arg Leu Leu Gly Met Ala Pro Leu Leu Pro Glu 
            100                 105                 110         


His Tyr Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    130                 135                 140                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Ala Ala Ser Arg Asp Ala Tyr Phe Asn Asn Tyr Met 
                165                 170                 175     


Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val Ser Ser 
            180                 185                 190         


Ile Ala Thr Asn Thr Gly Asn Asp Tyr Tyr Ala Asp Ser Val Lys Gly 
        195                 200                 205             


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ile Tyr Leu Gln 
    210                 215                 220                 


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
225                 230                 235                 240 


Gly Trp Arg Gly Gly Ser Phe Trp Thr Pro Ser Lys Tyr Ser Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Ser Lys Tyr Gly Pro 
            260                 265                 270         


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
        275                 280                 285             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    290                 295                 300                 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
305                 310                 315                 320 


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                325                 330                 335     


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
            340                 345                 350         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        355                 360                 365             


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
    370                 375                 380                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
385                 390                 395                 400 


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                405                 410                 415     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            420                 425                 430         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        435                 440                 445             


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
    450                 455                 460                 


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
465                 470                 475                 480 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
                485                 490                 495 


<210>  22
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFH

<400>  22

Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      


Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          


Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys 
        35                  40                  45              


Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  


Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  


Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      


Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         


Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             


Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 


Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 


Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     


Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         


Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             


Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 


Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 


Leu Pro Ser Cys Glu Glu Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro 
                245                 250                 255     


Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro 
            260                 265                 270         


Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly 
        275                 280                 285             


Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys 
    290                 295                 300                 


Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn 
305                 310                 315                 320 


Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly 
                325                 330                 335     


Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg 
            340                 345                 350         


Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro 
        355                 360                 365             


Thr Cys Ala Lys Arg 
    370             


<210>  23
<211>  873
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SLN6074, C2_D2-Fc-CFH fusion)

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Tyr Thr Ser Ser Thr Tyr 
            20                  25                  30          


Tyr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ala Tyr Ala Gly Gly Gly Gly Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Met Ser Arg Leu Leu Gly Met Ala Pro Leu Leu Pro Glu 
            100                 105                 110         


His Tyr Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    130                 135                 140                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Ala Ala Ser Arg Asp Ala Tyr Phe Asn Asn Tyr Met 
                165                 170                 175     


Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val Ser Ser 
            180                 185                 190         


Ile Ala Thr Asn Thr Gly Asn Asp Tyr Tyr Ala Asp Ser Val Lys Gly 
        195                 200                 205             


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ile Tyr Leu Gln 
    210                 215                 220                 


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
225                 230                 235                 240 


Gly Trp Arg Gly Gly Ser Phe Trp Thr Pro Ser Lys Tyr Ser Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Ser Lys Tyr Gly Pro 
            260                 265                 270         


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
        275                 280                 285             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    290                 295                 300                 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
305                 310                 315                 320 


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                325                 330                 335     


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
            340                 345                 350         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        355                 360                 365             


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
    370                 375                 380                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
385                 390                 395                 400 


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                405                 410                 415     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            420                 425                 430         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        435                 440                 445             


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
    450                 455                 460                 


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
465                 470                 475                 480 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly 
                485                 490                 495     


Gly Gly Gly Ser Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr 
            500                 505                 510         


Glu Ile Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr 
        515                 520                 525             


Gln Ala Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val 
    530                 535                 540                 


Ile Met Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg 
545                 550                 555                 560 


Lys Cys Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly 
                565                 570                 575     


Thr Phe Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala 
            580                 585                 590         


Val Tyr Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr 
        595                 600                 605             


Arg Glu Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu 
    610                 615                 620                 


Val Val Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val 
625                 630                 635                 640 


Ser Ser Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val 
                645                 650                 655     


Arg Phe Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met 
            660                 665                 670         


His Cys Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val 
        675                 680                 685             


Glu Ile Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser 
    690                 695                 700                 


Gln Lys Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn 
705                 710                 715                 720 


Met Gly Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser 
                725                 730                 735     


Gly Trp Arg Pro Leu Pro Ser Cys Glu Glu Ser Thr Gly Lys Cys Gly 
            740                 745                 750         


Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser 
        755                 760                 765             


Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr 
    770                 775                 780                 


Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser 
785                 790                 795                 800 


Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met 
                805                 810                 815     


Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr 
            820                 825                 830         


Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr Arg 
        835                 840                 845             


Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys 
    850                 855                 860                 


Leu Glu Tyr Pro Thr Cys Ala Lys Arg 
865                 870             


<210>  24
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLN-6068(C2-11) /SLN-6062(C8-9) /SLN-6065(D2-9) FR1

<400>  24

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  25
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLN-6068(C2-11) FR2

<400>  25

Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val Ala 
1               5                   10                  


<210>  26
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLN-6068(C2-11) FR3

<400>  26

Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  27
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLN-6068(C2-11) /SLN-6062(C8-9) /SLN-6065(D2-9) /SLN6043(F6-1) FR4

<400>  27

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  28
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLN-6043 (F6-1) FR1

<400>  28

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  29
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLN-6043 (F6-1) FR2

<400>  29

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  30
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLN-6043 (F6-1) FR3

<400>  30

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys Gln Thr 
            20                  25                  30          


<210>  31
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLN-6062 (C8-9) FR2

<400>  31

Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val Ser 
1               5                   10                  


<210>  32
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLN-6062 (C8-9) FR3

<400>  32

Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Lys Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  33
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLN-6065 (D2-9) FR2

<400>  33

Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val Ser 
1               5                   10                  


<210>  34
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLN-6065 (D2-9) FR3

<400>  34

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ile Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  35
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLN-6068(C2-11) FR1; SLN-6062 (C8-9) FR1; SLN-6065 (D2-9) FR1; SLN-6043 (F6-1) FR1

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = Leu or Val

<400>  35

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Xaa Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  36
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLN-6068(C2-11) FR2; SLN-6043 (F6-1) FR2; SLN-6062 (C8-9) FR2; SLN-6065 (D2-9) FR2

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = Phe or Val

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = Leu or Arg

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = Gly, Leu or Trp

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = Ala or Ser

<400>  36

Trp Xaa Arg Gln Ala Pro Gly Lys Gly Xaa Glu Xaa Val Xaa 
1               5                   10                  


<210>  37
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLN-6068(C2-11) FR3; SLN-6043 (F6-1) FR3; SLN-6062 (C8-9) FR3; SLN-6065 (D2-9) FR3

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = Gln or Arg

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = Lys or Asn

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = Ser or Thr

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = Ile or Leu

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa = Ala or Thr

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa = Leu or Val

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa = Ala or Gln

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa = Ala or Thr

<400>  37

Arg Phe Thr Ile Ser Xaa Asp Asn Ser Lys Xaa Xaa Xaa Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Xaa Glu Asp Thr Ala Xaa Tyr Tyr Cys Xaa Xaa 
            20                  25                  30          

<210>  38
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLN-6066

<400>  38

Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu Ile Ile His 
1               5                   10                  15      


Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val Thr Ser Pro 
            20                  25                  30          


Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr Leu Ile Pro 
        35                  40                  45              


Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe Ile Ile Ser 
    50                  55                  60                  


Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu Ala Thr Val 
65                  70                  75                  80  


Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg Gln Thr Asn 
                85                  90                  95      


Thr Ile Ile Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser 
            100                 105                 110         


Val Gly Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn 
        115                 120                 125             


Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His 
    130                 135                 140                 


Lys Lys Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met 
145                 150                 155                 160 


Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp 
                165                 170                 175     


Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys 
            180                 185                 190         


Asn Ser Thr Phe Val Arg Val His Glu Lys Asp Lys Thr His Thr Cys 
        195                 200                 205             


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
    210                 215                 220                 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
225                 230                 235                 240 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
                245                 250                 255     


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
            260                 265                 270         


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
        275                 280                 285             


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
    290                 295                 300                 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
305                 310                 315                 320 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
                325                 330                 335     


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
            340                 345                 350         


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
        355                 360                 365             


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
    370                 375                 380                 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
385                 390                 395                 400 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
                405                 410                 415     


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            420                 425                 

