                         б


<110>  йѧԺо;йѧԺоϢģ
 
<120>  CPEƱٽԭλ񾭷˥ԼҩеӦ

<130>  GNPSQ22013

<150>CN202111352889.6
<151>2021-11-16

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  1431
<212>  DNA
<213>  ˹УArtificial Sequence

<400>  1
atggccgggc gagggggcag cgcgctgctg gctctgtgcg gggcactggc tgcctgcggg       60

tggctcctgg gcgccgaagc ccaggagccc ggggcgcccg cggcgggcat gaggcggcgc      120

cggcggctgc agcaagagga cggcatctcc ttcgagtacc accgctaccc cgagctgcgc      180

gaggcgctcg tgtccgtgtg gctgcagtgc accgccatca gcaggattta cacggtgggg      240

cgcagcttcg agggccggga gctcctggtc atcgagctgt ccgacaaccc tggcgtccat      300

gagcctggtg agcctgaatt taaatacatt gggaatatgc atgggaatga ggctgttgga      360

cgagaactgc tcattttctt ggcccagtac ctatgcaacg aataccagaa ggggaacgag      420

acaattgtca acctgatcca cagtacccgc attcacatca tgccttccct gaacccagat      480

ggctttgaga aggcagcgtc tcagcctggt gaactcaagg actggtttgt gggtcgaagc      540

aatgcccagg gaatagatct gaaccggaac tttccagacc tggataggat agtgtacgtg      600

aatgagaaag aaggtggtcc aaataatcat ctgttgaaaa atatgaagaa aattgtggat      660

caaaacacaa agcttgctcc tgagaccaag gctgtcattc attggattat ggatattcct      720

tttgtgcttt ctgccaatct ccatggagga gaccttgtgg ccaattatcc atatgatgag      780

acgcggagtg gtagtgctca cgaatacagc tcctccccag atgacgccat tttccaaagc      840

ttggcccggg catactcttc tttcaacccg gccatgtctg accccaatcg gccaccatgt      900

cgcaagaatg atgatgacag cagctttgta gatggaacca ccaacggtgg tgcttggtac      960

agcgtacctg gagggatgca agacttcaat taccttagca gcaactgttt tgagatcacc     1020

gtggagctta gctgtgagaa gttcccacct gaagagactc tgaagaccta ctgggaggat     1080

aacaaaaact ccctcattag ctaccttgag cagatacacc gaggagttaa aggatttgtc     1140

cgagaccttc aaggtaaccc aattgcgaat gccaccatct ccgtggaagg aatagaccac     1200

gatgttacat ccgcaaagga tggtgattac tggagattgc ttatacctgg aaactataaa     1260

cttacagcct cagctccagg ctatctggca ataacaaaga aagtggcagt tccttacagc     1320

cctgctgctg gggttgattt tgaactggag tcattttctg aaaggaaaga agaggagaag     1380

gaagaattga tggaatggtg gaaaatgatg tcagaaactt taaattttta a              1431


<210>  2
<211>  476
<212>  PRT
<213>  ˣHomo sapiens

<400>  2

Met Ala Gly Arg Gly Gly Ser Ala Leu Leu Ala Leu Cys Gly Ala Leu 
1               5                   10                  15      


Ala Ala Cys Gly Trp Leu Leu Gly Ala Glu Ala Gln Glu Pro Gly Ala 
            20                  25                  30          


Pro Ala Ala Gly Met Arg Arg Arg Arg Arg Leu Gln Gln Glu Asp Gly 
        35                  40                  45              


Ile Ser Phe Glu Tyr His Arg Tyr Pro Glu Leu Arg Glu Ala Leu Val 
    50                  55                  60                  


Ser Val Trp Leu Gln Cys Thr Ala Ile Ser Arg Ile Tyr Thr Val Gly 
65                  70                  75                  80  


Arg Ser Phe Glu Gly Arg Glu Leu Leu Val Ile Glu Leu Ser Asp Asn 
                85                  90                  95      


Pro Gly Val His Glu Pro Gly Glu Pro Glu Phe Lys Tyr Ile Gly Asn 
            100                 105                 110         


Met His Gly Asn Glu Ala Val Gly Arg Glu Leu Leu Ile Phe Leu Ala 
        115                 120                 125             


Gln Tyr Leu Cys Asn Glu Tyr Gln Lys Gly Asn Glu Thr Ile Val Asn 
    130                 135                 140                 


Leu Ile His Ser Thr Arg Ile His Ile Met Pro Ser Leu Asn Pro Asp 
145                 150                 155                 160 


Gly Phe Glu Lys Ala Ala Ser Gln Pro Gly Glu Leu Lys Asp Trp Phe 
                165                 170                 175     


Val Gly Arg Ser Asn Ala Gln Gly Ile Asp Leu Asn Arg Asn Phe Pro 
            180                 185                 190         


Asp Leu Asp Arg Ile Val Tyr Val Asn Glu Lys Glu Gly Gly Pro Asn 
        195                 200                 205             


Asn His Leu Leu Lys Asn Met Lys Lys Ile Val Asp Gln Asn Thr Lys 
    210                 215                 220                 


Leu Ala Pro Glu Thr Lys Ala Val Ile His Trp Ile Met Asp Ile Pro 
225                 230                 235                 240 


Phe Val Leu Ser Ala Asn Leu His Gly Gly Asp Leu Val Ala Asn Tyr 
                245                 250                 255     


Pro Tyr Asp Glu Thr Arg Ser Gly Ser Ala His Glu Tyr Ser Ser Ser 
            260                 265                 270         


Pro Asp Asp Ala Ile Phe Gln Ser Leu Ala Arg Ala Tyr Ser Ser Phe 
        275                 280                 285             


Asn Pro Ala Met Ser Asp Pro Asn Arg Pro Pro Cys Arg Lys Asn Asp 
    290                 295                 300                 


Asp Asp Ser Ser Phe Val Asp Gly Thr Thr Asn Gly Gly Ala Trp Tyr 
305                 310                 315                 320 


Ser Val Pro Gly Gly Met Gln Asp Phe Asn Tyr Leu Ser Ser Asn Cys 
                325                 330                 335     


Phe Glu Ile Thr Val Glu Leu Ser Cys Glu Lys Phe Pro Pro Glu Glu 
            340                 345                 350         


Thr Leu Lys Thr Tyr Trp Glu Asp Asn Lys Asn Ser Leu Ile Ser Tyr 
        355                 360                 365             


Leu Glu Gln Ile His Arg Gly Val Lys Gly Phe Val Arg Asp Leu Gln 
    370                 375                 380                 


Gly Asn Pro Ile Ala Asn Ala Thr Ile Ser Val Glu Gly Ile Asp His 
385                 390                 395                 400 


Asp Val Thr Ser Ala Lys Asp Gly Asp Tyr Trp Arg Leu Leu Ile Pro 
                405                 410                 415     


Gly Asn Tyr Lys Leu Thr Ala Ser Ala Pro Gly Tyr Leu Ala Ile Thr 
            420                 425                 430         


Lys Lys Val Ala Val Pro Tyr Ser Pro Ala Ala Gly Val Asp Phe Glu 
        435                 440                 445             


Leu Glu Ser Phe Ser Glu Arg Lys Glu Glu Glu Lys Glu Glu Leu Met 
    450                 455                 460                 


Glu Trp Trp Lys Met Met Ser Glu Thr Leu Asn Phe 
465                 470                 475     


<210>  3
<211>  53
<212>  DNA
<213>  ˹УArtificial Sequence

<400>  3
gcctcgaggt ttaaactacg ggatccgcca ccatggacga gaagaccacc ggc              53


<210>  4
<211>  51
<212>  DNA
<213>  ˹УArtificial Sequence

<400>  4
gaattggcca ctagtcccgg gaattcttaa aaatttaaag tttctgacat c                51


<210>  5
<211>  476
<212>  PRT
<213>  ˹УArtificial Sequence

<400>  5

Met Ala Gly Arg Gly Gly Ser Ala Leu Leu Ala Leu Cys Gly Ala Leu 
1               5                   10                  15      


Ala Ala Cys Gly Trp Leu Leu Gly Ala Glu Ala Gln Glu Pro Gly Ala 
            20                  25                  30          


Pro Ala Ala Gly Met Arg Arg Arg Arg Arg Leu Gln Gln Glu Asp Gly 
        35                  40                  45              


Ile Ser Phe Glu Tyr His Arg Tyr Pro Glu Leu Arg Glu Ala Leu Val 
    50                  55                  60                  


Ser Val Trp Leu Gln Cys Thr Ala Ile Ser Arg Ile Tyr Thr Val Gly 
65                  70                  75                  80  


Arg Ser Phe Glu Gly Arg Glu Leu Leu Val Ile Glu Leu Ser Asp Asn 
                85                  90                  95      


Pro Gly Val His Glu Pro Gly Glu Pro Glu Phe Lys Tyr Ile Gly Asn 
            100                 105                 110         


Met His Gly Asn Glu Ala Val Gly Arg Glu Leu Leu Ile Phe Leu Ala 
        115                 120                 125             


Gln Tyr Leu Cys Asn Glu Tyr Gln Lys Gly Asn Glu Thr Ile Val Asn 
    130                 135                 140                 


Leu Ile His Ser Thr Arg Ile His Ile Met Pro Ser Leu Asn Pro Asp 
145                 150                 155                 160 


Gly Phe Glu Lys Ala Ala Ser Gln Pro Gly Glu Leu Lys Asp Trp Phe 
                165                 170                 175     


Val Gly Arg Ser Asn Ala Gln Gly Ile Asp Leu Asn Arg Asn Phe Pro 
            180                 185                 190         


Asp Leu Asp Arg Ile Val Tyr Val Asn Glu Lys Glu Gly Gly Pro Asn 
        195                 200                 205             


Asn His Leu Leu Lys Asn Met Lys Lys Ile Val Asp Gln Asn Thr Lys 
    210                 215                 220                 


Leu Ala Pro Glu Thr Lys Ala Val Ile His Trp Ile Met Asp Ile Pro 
225                 230                 235                 240 


Phe Val Leu Ser Ala Asn Leu His Gly Gly Asp Leu Val Ala Asn Tyr 
                245                 250                 255     


Pro Tyr Asp Glu Thr Arg Ser Gly Ser Ala His Glu Tyr Ser Ser Ser 
            260                 265                 270         


Pro Asp Asp Ala Ile Phe Gln Ser Leu Ala Arg Ala Tyr Ser Ser Phe 
        275                 280                 285             


Asn Pro Ala Met Ser Asp Pro Asn Arg Pro Pro Cys Arg Lys Asn Asp 
    290                 295                 300                 


Asp Asp Ser Ser Phe Val Asp Gly Thr Thr Asn Gly Gly Ala Trp Tyr 
305                 310                 315                 320 


Ser Val Pro Gly Gly Met Gln Asp Phe Asn Tyr Leu Ser Ser Asn Cys 
                325                 330                 335     


Phe Glu Ile Thr Val Gln Leu Ser Cys Glu Lys Phe Pro Pro Glu Glu 
            340                 345                 350         


Thr Leu Lys Thr Tyr Trp Glu Asp Asn Lys Asn Ser Leu Ile Ser Tyr 
        355                 360                 365             


Leu Glu Gln Ile His Arg Gly Val Lys Gly Phe Val Arg Asp Leu Gln 
    370                 375                 380                 


Gly Asn Pro Ile Ala Asn Ala Thr Ile Ser Val Glu Gly Ile Asp His 
385                 390                 395                 400 


Asp Val Thr Ser Ala Lys Asp Gly Asp Tyr Trp Arg Leu Leu Ile Pro 
                405                 410                 415     


Gly Asn Tyr Lys Leu Thr Ala Ser Ala Pro Gly Tyr Leu Ala Ile Thr 
            420                 425                 430         


Lys Lys Val Ala Val Pro Tyr Ser Pro Ala Ala Gly Val Asp Phe Glu 
        435                 440                 445             


Leu Glu Ser Phe Ser Glu Arg Lys Glu Glu Glu Lys Glu Glu Leu Met 
    450                 455                 460                 


Glu Trp Trp Lys Met Met Ser Glu Thr Leu Asn Phe 
465                 470                 475     


<210>  6
<211>  58
<212>  DNA
<213>  ˹УArtificial Sequence

<400>  6
ccggggatta ctggcgattg cttgcctcga ggcaagcaat cgccagtaat cctttttg         58


<210>  7
<211>  58
<212>  DNA
<213>  ˹УArtificial Sequence

<400>  7
ccggggttgt gtgcagttga tatttctcga gaaatatcaa ctgcacacaa cctttttg         58


<210>  8
<211>  57
<212>  DNA
<213>  ˹УArtificial Sequence

<400>  8
ccggttctcc gaacgtgtca cgttctcgag aacgtgacac gttcggagaa ttttttg          57


<210>  9
<211>  21
<212>  RNA
<213>  ˹УArtificial Sequence

<400>  9
aacccucuug cccucuccua g                                                 21


<210>  10
<211>  21
<212>  RNA
<213>  ˹УArtificial Sequence

<400>  10
aggagagggc aagaggguuu u                                                 21


<210>  11
<211>  20
<212>  RNA
<213>  ˹УArtificial Sequence

<400>  11
uugggagggu ccuggggagg                                                   20


<210>  12
<211>  20
<212>  RNA
<213>  ˹УArtificial Sequence

<400>  12
uccccaggac ccucccaauu                                                   20
