﻿ 序列表

<110>  浙江迪福润丝生物科技有限公司

<120>  一种包含新型冠状病毒双抗原靶标序列组合的重组新城疫病毒载体及相应疫苗株和疫苗

<160>  56

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  227
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  1
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          
Ile Ser Arg Thr Pro Gly Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                75                  80  
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150               155                 160 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 
Pro Gly Lys 
225         

<210>  2
<211>  163
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  2
Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Asn Ser 
1               5                   10                  15      
Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu 
            20                  25                  30          
Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu 
        35                  40                  45              
His Ala Lys Lys Leu Ile Val Phe Leu Asn Glu Asn Asn Val Pro Val 
    50                  55                  60                  
Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr 
65                  70                75                  80  
Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser 
                85                  90                  95      
Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr 
            100                 105                 110         
Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val 
        115                 120                 125             
Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn 
    130                 135                 140                 
His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser 
145                 150               155                 160 
Arg Lys Ser 
            

<210>  3
<211>  27
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  3
Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
1               5                   10                  15      
Asp Gly Glu Trp Val Phe Leu Ser Thr Phe Leu 
            20                  25          

<210>  4
<211>  24
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  4
Ile Asn His Val Gly Gly Thr Gly Gly Ala Ile Met Ala Pro Val Ala 
1               5                   10                  15      
Val Thr Arg Gln Leu Val Gly Ser 
            20                  

<210>  5
<211>  16
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  5
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Ser Ser Ala Tyr Ser 
1               5                   10                  15      

<210>  6
<211>  19
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  6
Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      
Val Leu Ser 
            

<210>  7
<211>  24
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  7
Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      
Met Leu Val Ala Ser Cys Leu Gly 
            20                  

<210>  8
<211>  19
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  8
Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      
Pro Gly Pro 
            

<210>  9
<211>  22
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>9
catgttcgtg tttctggtgc tg 22

<210>10
<211>28
<212>DNA
<213>人工序列(Artificial Sequence)

<400>10
ttaaactcag gtgtagtgca gtttcacg 28

<210>11
<211>35
<212>DNA
<213>人工序列(Artificial Sequence)

<400>11
tgagtttaaa cttagaaaaa atacgggtag aattg 35

<210>12
<211>23
<212>DNA
<213>人工序列(Artificial Sequence)

<400>12
accaaacaaa gatttggtga atg 23

<210>13
<211>40
<212>DNA
<213>人工序列(Artificial Sequence)

<400>13
caattattct tgagtgtagt ctcgtcattc accaaatctt 40

<210>14
<211>18
<212>DNA
<213>人工序列(Artificial Sequence)

<400>14
agaaacacga acatggtg 18

<210>15
<211>41
<212>DNA
<213>人工序列(Artificial Sequence)

<400>15
ttagaaaaaa tacgggtaga agccaccatg aagcacctgt g 41

<210>16
<211>42
<212>DNA
<213>人工序列(Artificial Sequence)

<400>16
ccgtattttt tctaaatctt aaatgtagct agattaatta cg 42

<210>17
<211>39
<212>DNA
<213>人工序列(Artificial Sequence)

<400>17
cgggtagaag ccaccatgaa gcacctgtgg ttctttctg 39

<210>18
<211>37
<212>DNA
<213>人工序列(Artificial Sequence)

<400>18
ccgtattttt tctaattatt tacccggaga cagggag 37

<210>19
<211>48
<212>DNA
<213>人工序列(Artificial Sequence)

<400>19
ttagaaaaaa tacgggtaga attggagtgc cccaattgtg ccaagatg 48

<210>20
<211>57
<212>DNA
<213>人工序列(Artificial Sequence)

<400>20
ggtggcttct acccgtattt tttctaagtt taaactcagg tgtagtgcag tttcacg 57

<210>21
<211>38
<212>DNA
<213>人工序列(Artificial Sequence)

<400>21
cgggtagaag ccaccatgaa atgggtcacc tttatcag 38

<210>22
<211>35
<212>DNA
<213>人工序列(Artificial Sequence)

<400>22
ccgtattttt tctaatcatt tgccggggct cagag 35

<210>23
<211>37
<212>DNA
<213>人工序列(Artificial Sequence)

<400>23
ccgtattttt tctaattaca ggaaggtgct caggaac 37

<210>24
<211>59
<212>DNA
<213>人工序列(Artificial Sequence)

<400>24
ggtggcggct tctacccgta ttttttctaa gtttaaactc aggtgtagtg cagtttcac 59

<210>25
<211>35
<212>DNA
<213>人工序列(Artificial Sequence)

<400>25
gttttttgtg tcatgtcatt tgccggggct cagag 35

<210>26
<211>22
<212>DNA
<213>人工序列(Artificial Sequence)

<400>26
catgacacaa aaaactaatc tg 22

<210>27
<211>52
<212>DNA
<213>人工序列(Artificial Sequence)

<400>27
ggtggcttct acccgtattt tttctaaatg atctgggtga gtgggcggag cg 52

<210>28
<211>37
<212>DNA
<213>人工序列(Artificial Sequence)

<400>28
gttttttgtg tcatgtcagc tctttctgct cttggcg 37

<210>29
<211>38
<212>DNA
<213>人工序列(Artificial Sequence)

<400>29
gttttttgtg tcatgtcaag agcccacgag ctgtcttg 38

<210>30
<211>55
<212>DNA
<213>人工序列(Artificial Sequence)

<400>30
ggtggcggct tctacccgta ttttttctaa atgatctggg tgagtgggcg gagcg 55

<210>31
<211>40
<212>DNA
<213>人工序列(Artificial Sequence)

<400>31
gttttttgtg tcatgtcatt tgttcttcac gagattggtg 40

<210>32
<211>40
<212>DNA
<213>人工序列(Artificial Sequence)

<400>32
ccgtattttt tctaatcatt tgttcttcac gagattggtg 40

<210>33
<211>18
<212>DNA
<213>人工序列(Artificial Sequence)

<400>33
atgttcgtgt ttctggtg 18

<210>34
<211>23
<212>DNA
<213>人工序列(Artificial Sequence)

<400>34
tctggctctc cgagggctgt ttg 23

<210>35
<211>40
<212>DNA
<213>人工序列(Artificial Sequence)

<400>35
cctcggagag ccagatctgt ggccagccag agcatcattg 40

<210>36
<211>40
<212>DNA
<213>人工序列(Artificial Sequence)

<400>36
ctaagtttaa acttacagga aggtgctcag gaacacccac 40

<210>37
<211>35
<212>DNA
<213>人工序列(Artificial Sequence)

<400>37
taagtttaaa cttagaaaaa atacgggtag aattg 35

<210>38
<211>45
<212>DNA
<213>人工序列(Artificial Sequence)

<400>38
cagaaacacg aacatggtgg cggttctacc cgtatttttt ctaag 45

<210>39
<211>22
<212>DNA
<213>人工序列(Artificial Sequence)

<400>39
caccatgttc gtgtttctgg tg 22

<210>40
<211>33
<212>DNA
<213>人工序列(Artificial Sequence)

<400>40
tctggctctc cgtctgctgt tggtctgtgt ctg 33

<210>41
<211>36
<212>DNA
<213>人工序列(Artificial Sequence)

<400>41
agacggagag ccagatctgt ggccagccag agcatc 36

<210>42
<211>26
<212>DNA
<213>人工序列(Artificial Sequence)

<400>42
ttaaactcac atctttgtgg tggctc 26

<210>  43
<211>  273
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  43
Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      
Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          
Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              
Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  
Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                75                  80  
Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      
Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         
Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             
Gly Asn Tyr Asn Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 
Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Lys 
145                 150               155                 160 
Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     
Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         
Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             
Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
    210                 215                 220                 
Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
225                 230               235                 240 
Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
                245                 250                 255     
Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
            260                 265                 270         
Ser 

<210>44
<211>21
<212>DNA
<213>人工序列(Artificial Sequence)

<400>44
aaggtccaac tctccaagcg g 21

<210>45
<211>23
<212>DNA
<213>人工序列(Artificial Sequence)

<400>45
gtcctcctta ctatcagtcc aca 23

<210>46
<211>20
<212>DNA
<213>人工序列(Artificial Sequence)

<400>46
caggtggcca agatactctg 20

<210>47
<211>19
<212>DNA
<213>人工序列(Artificial Sequence)

<400>47
cttggtagaa ggtctggag 19

<210>  48
<211>  553
<212>  PRT
<213>  新城疫病毒(Newcastle disease virus)

<400>  48
Met Gly Ser Arg Pro Ser Thr Lys Asn Pro Ala Pro Met Met Leu Thr 
1               5                   10                  15      
Ile Arg Val Ala Leu Val Leu Ser Cys Ile Cys Pro Ala Asn Ser Ile 
            20                  25                  30          
Asp Gly Arg Pro Leu Ala Ala Ala Gly Ile Val Val Thr Gly Asp Lys 
        35                  40                  45              
Ala Val Asn Ile Tyr Thr Ser Ser Gln Thr Gly Ser Ile Ile Val Lys 
    50                  55                  60                  
Leu Leu Pro Asn Leu Pro Lys Asp Lys Glu Ala Cys Ala Lys Ala Pro 
65                  70                 75                  80  
Leu Asp Ala Tyr Asn Arg Thr Leu Thr Thr Leu Leu Thr Pro Leu Gly 
                85                  90                  95      
Asp Ser Ile Arg Arg Ile Gln Glu Ser Val Thr Thr Ser Gly Gly Gly 
            100                 105                 110         
Arg Gln Gly Arg Leu Ile Gly Ala Ile Ile Gly Gly Val Ala Leu Gly 
        115                 120                 125             
Val Ala Thr Ala Ala Gln Ile Thr Ala Ala Ala Ala Leu Ile Gln Ala 
    130                 135                 140                 
Lys Gln Asn Ala Ala Asn Ile Leu Arg Leu Lys Glu Ser Ile Ala Ala 
145                 150               155                 160 
Thr Asn Glu Ala Val His Glu Val Thr Asp Gly Leu Ser Gln Leu Ala 
                165                 170                 175     
Val Ala Val Gly Lys Met Gln Gln Phe Val Asn Asp Gln Phe Asn Lys 
            180                 185                 190         
Thr Ala Gln Glu Leu Asp Cys Ile Lys Ile Ala Gln Gln Val Gly Val 
        195                 200                 205             
Glu Leu Asn Leu Tyr Leu Thr Glu Leu Thr Thr Val Phe Gly Pro Gln 
    210                 215                 220                 
Ile Thr Ser Pro Ala Leu Asn Lys Leu Thr Ile Gln Ala Leu Tyr Asn 
225                 230               235                 240 
Leu Ala Gly Gly Asn Met Asp Tyr Leu Leu Thr Lys Leu Gly Val Gly 
                245                 250                 255     
Asn Asn Gln Leu Ser Ser Leu Ile Gly Ser Gly Leu Ile Thr Gly Asn 
            260                 265                 270         
Pro Ile Leu Tyr Asp Ser Gln Thr Gln Leu Leu Gly Ile Gln Val Thr 
        275                 280                 285             
Leu Pro Ser Val Gly Asn Leu Asn Asn Met Arg Ala Thr Tyr Leu Glu 
    290                 295                 300                 
Thr Leu Ser Val Ser Thr Thr Arg Gly Phe Ala Ser Ala Leu Val Pro 
305                 310               315                 320 
Lys Val Val Thr Gln Val Gly Ser Val Ile Glu Glu Leu Asp Thr Ser 
                325                 330                 335     
Tyr Cys Ile Glu Thr Asp Leu Asp Leu Tyr Cys Thr Arg Ile Val Thr 
            340                 345                 350         
Phe Pro Met Ser Pro Gly Ile Tyr Ser Cys Leu Ser Gly Asn Thr Ser 
        355                 360                 365             
Ala Cys Met Tyr Ser Lys Thr Glu Gly Ala Leu Thr Thr Pro Tyr Met 
    370                 375                 380                 
Thr Ile Lys Gly Ser Val Ile Ala Asn Cys Lys Met Thr Thr Cys Arg 
385                 390              395                 400 
Cys Val Asn Pro Pro Gly Ile Ile Ser Gln Asn Tyr Gly Glu Ala Val 
                405                 410                 415     
Ser Leu Ile Asp Lys Gln Ser Cys Asn Val Leu Ser Leu Gly Gly Ile 
            420                 425                 430         
Thr Leu Arg Leu Ser Gly Glu Phe Asp Val Thr Tyr Gln Lys Asn Ile 
        435                 440                 445             
Ser Ile Gln Asp Ser Gln Val Ile Ile Thr Gly Asn Leu Asp Ile Ser 
    450                 455                 460                 
Thr Glu Leu Gly Asn Val Asn Asn Ser Ile Ser Asn Ala Leu Asn Lys 
465                 470               475                 480 
Leu Glu Glu Ser Asn Arg Lys Leu Asp Lys Val Asn Val Lys Leu Thr 
                485                 490                 495     
Ser Thr Ser Ala Leu Ile Thr Tyr Ile Val Leu Thr Ile Ile Ser Leu 
            500                 505                 510         
Val Phe Gly Ile Leu Ser Leu Ile Leu Ala Cys Tyr Leu Met Tyr Lys 
        515                 520                 525             
Gln Lys Ala Gln Gln Lys Thr Leu Leu Trp Leu Gly Asn Asn Thr Leu 
    530                 535                 540                 
Asp Gln Met Arg Ala Thr Thr Lys Met 
545                 550             

<210>  49
<211>  38
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  49
agaagtgccg ccaccatgaa atgggtcacc tttatcag                     38

<210>  50
<211>  35
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  50
ctaagtttaa actcaagagc ccacgagctg tcttg                        35

<210>  51
<211>  57
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  51
ggtggcggca cttctacccg tattttttct aagtttaaac atcttaaatg tagctag           57

<210>  52
<211>  38
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  52
ggtagaaccg ccaccatgaa atgggtcacc tttatcag                     38

<210>  53
<211>  34
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  53
ctaagtttaa actcacagga aggtgctcag gaac                             34

<210>  54
<211>  54
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  54
ggtggcggtt ctacccgtat tttttctaag tttaaacatc ttaaatgtag ctag              54

<210>  55
<211>  288
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  55
Val Asn Leu Arg Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      
Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          
Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              
Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  
Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                75                  80  
Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      
Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         
Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Asp Val 
        115                 120                 125             
Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Gly Val Tyr Ser 
    130                 135                 140                 
Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met 
145                 150               155                 160 
Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val 
                165                 170                 175     
Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro 
            180                 185                 190         
Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro 
        195                 200                 205             
Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu 
    210                 215                 220                 
Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly 
225                 230               235                 240 
Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg 
                245                 250                 255     
Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val 
            260                 265                 270         
Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser 
        275                 280                 285             

<210>  56
<211>  1271
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  56
Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      
Asn Leu Arg Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          
Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              
His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  
Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70              75                  80  
Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      
Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         
Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             
Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Asp Val Tyr 
    130                 135                 140                 
Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Gly Val Tyr Ser Ser 
145                 150             155                 160 
Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp 
                165                 170                 175     
Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe 
            180                 185                 190         
Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile 
        195                 200                 205             
Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu 
    210                 215                 220                 
Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu 
225                 230             235                 240 
Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp 
                245                 250                 255     
Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr 
            260                 265                 270         
Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp 
        275                 280                 285             
Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe 
    290                 295                 300                 
Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro 
305                 310            315                 320 
Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe 
                325                 330                 335     
Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn 
            340                 345                 350         
Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn 
        355                 360                 365             
Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys 
    370                 375                 380                 
Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile 
385                 390             395                 400 
Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile 
                405                 410                 415     
Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile 
            420                 425                 430         
Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn 
        435                 440                 445             
Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg 
    450                 455                 460                 
Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Lys Pro Cys Asn Gly 
465                 470            475                 480 
Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln 
                485                 490                 495     
Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser 
            500                 505                 510         
Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser 
        515                 520                 525             
Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu 
    530                 535                 540                 
Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe 
545                 550             555                 560 
Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp 
                565                 570                 575     
Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly 
            580                 585                 590         
Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val 
        595                 600                 605             
Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala 
    610                 615                 620                 
Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val 
625                 630              635                 640 
Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn 
                645                 650                 655     
Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr 
            660                 665                 670         
Gln Thr Gln Thr Asn Ser Arg Arg Arg Ala Arg Ser Val Ala Ser Gln 
        675                 680                 685             
Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala 
    690                 695                 700                 
Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val 
705                 710               715                 720 
Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys 
                725                 730                 735     
Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu 
            740                 745                 750         
Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile 
        755                 760                 765             
Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys 
    770                 775                 780                 
Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe 
785                 790            795                 800 
Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile 
                805                 810                 815     
Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile 
            820                 825                 830         
Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile 
        835                 840                 845             
Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr 
    850                 855                 860                 
Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile 
865                 870         875                 880 
Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe 
                885                 890                 895     
Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn 
            900                 905                 910         
Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala 
        915                 920                 925             
Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly 
    930                 935                 940                 
Lys Leu Gln Asn Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu 
945                 950          955                 960 
Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn 
                965                 970                 975     
Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp 
            980                 985                 990         
Arg Leu Ile Thr Gly Arg Leu Gln  Ser Leu Gln Thr Tyr  Val Thr Gln 
        995                 1000                 1005             
Gln Leu  Ile Arg Ala Ala Glu  Ile Arg Ala Ser Ala  Asn Leu Ala Ala 
    1010                 1015                 1020                 
Thr  Lys Met Ser Glu Cys  Val Leu Gly Gln Ser  Lys Arg Val Asp Phe  
1025                 1030           1035                 1040 
Cys Gly Lys Gly Tyr  His Leu Met Ser Phe  Pro Gln Ser Ala Pro  His 
                1045            1050                 1055     
Gly Val Val Phe  Leu His Val Thr Tyr  Val Pro Ala Gln Glu  Lys Asn 
            1060                 1065                 1070         
Phe Thr Thr  Ala Pro Ala Ile Cys  His Asp Gly Lys Ala  His Phe Pro 
        1075                 1080                 1085             
Arg Glu  Gly Val Phe Val Ser  Asn Gly Thr His Trp  Phe Val Thr Gln 
    1090                 1095                 1100                 
Arg  Asn Phe Tyr Glu Pro  Gln Ile Ile Thr Thr  Asp Asn Thr Phe Val  
1105                 1110            1115                 1120 
Ser Gly Asn Cys Asp  Val Val Ile Gly Ile  Val Asn Asn Thr Val  Tyr 
                1125            1130                 1135     
Asp Pro Leu Gln  Pro Glu Leu Asp Ser  Phe Lys Glu Glu Leu  Asp Lys 
            1140                 1145                 1150         
Tyr Phe Lys  Asn His Thr Ser Pro  Asp Val Asp Leu Gly  Asp Ile Ser 
        1155                 1160                 1165             
Gly Ile  Asn Ala Ser Val Val  Asn Ile Gln Lys Glu  Ile Asp Arg Leu 
    1170                 1175                 1180                 
Asn  Glu Val Ala Lys Asn  Leu Asn Glu Ser Leu  Ile Asp Leu Gln Glu  
1185                 1190           1195                 1200 
Leu Gly Lys Tyr Glu  Gln Tyr Ile Lys Trp  Pro Trp Tyr Ile Trp  Leu 
                1205                1210                 1215     
Gly Phe Ile Ala  Gly Leu Ile Ala Ile  Val Met Val Thr Ile  Met Leu 
            1220                 1225                 1230         
Cys Cys Met  Thr Ser Cys Cys Ser  Cys Leu Lys Gly Cys  Cys Ser Cys 
        1235                 1240                 1245             
Gly Ser  Cys Cys Lys Phe Asp  Glu Asp Asp Ser Glu  Pro Val Leu Lys 
    1250                 1255                 1260                 
Gly  Val Lys Leu His Tyr  Thr 
1265                 1270     