                         SEQUENCE LISTING

<110>  Magellan Therapeutics Inc.
 
<120>  RECOMBINANT PROTEINS

<130>  50830-3032

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  2388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary recombinant protein of the invention with the following
       domain configuration: MBL-2 - L - MBL-2 - L -  MBL-2 -  MBL-2 - 
       MASP2 - MASP2

<400>  1

Met Ser Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu Ser Met Val Ala 
1               5                   10                  15      


Ala Ser Tyr Ser Glu Thr Val Thr Cys Glu Asp Ala Gln Lys Thr Cys 
            20                  25                  30          


Pro Ala Val Ile Ala Cys Ser Ser Pro Gly Ile Asn Gly Phe Pro Gly 
        35                  40                  45              


Lys Asp Gly Arg Asp Gly Thr Lys Gly Glu Lys Gly Glu Pro Gly Gln 
    50                  55                  60                  


Gly Leu Arg Gly Leu Gln Gly Pro Pro Gly Lys Leu Gly Pro Pro Gly 
65                  70                  75                  80  


Asn Pro Gly Pro Ser Gly Ser Pro Gly Pro Lys Gly Gln Lys Gly Asp 
                85                  90                  95      


Pro Gly Lys Ser Pro Asp Gly Asp Ser Ser Leu Ala Ala Ser Glu Arg 
            100                 105                 110         


Lys Ala Leu Gln Thr Glu Met Ala Arg Ile Lys Lys Trp Leu Thr Phe 
        115                 120                 125             


Ser Leu Gly Lys Gln Val Gly Asn Lys Phe Phe Leu Thr Asn Gly Glu 
    130                 135                 140                 


Ile Met Thr Phe Glu Lys Val Lys Ala Leu Cys Val Lys Phe Gln Ala 
145                 150                 155                 160 


Ser Val Ala Thr Pro Arg Asn Ala Ala Glu Asn Gly Ala Ile Gln Asn 
                165                 170                 175     


Leu Ile Lys Glu Glu Ala Phe Leu Gly Ile Thr Asp Glu Lys Thr Glu 
            180                 185                 190         


Gly Gln Phe Val Asp Leu Thr Gly Asn Arg Leu Thr Tyr Thr Asn Trp 
        195                 200                 205             


Asn Glu Gly Glu Pro Asn Asn Ala Gly Ser Asp Glu Asp Cys Val Leu 
    210                 215                 220                 


Leu Leu Lys Asn Gly Gln Trp Asn Asp Val Pro Cys Ser Thr Ser His 
225                 230                 235                 240 


Leu Ala Val Cys Glu Phe Pro Ile Gly Gly Gly Gly Gly Gly Gly Gly 
                245                 250                 255     


Gly Gly Gly Gly Met Ser Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu 
            260                 265                 270         


Ser Met Val Ala Ala Ser Tyr Ser Glu Thr Val Thr Cys Glu Asp Ala 
        275                 280                 285             


Gln Lys Thr Cys Pro Ala Val Ile Ala Cys Ser Ser Pro Gly Ile Asn 
    290                 295                 300                 


Gly Phe Pro Gly Lys Asp Gly Arg Asp Gly Thr Lys Gly Glu Lys Gly 
305                 310                 315                 320 


Glu Pro Gly Gln Gly Leu Arg Gly Leu Gln Gly Pro Pro Gly Lys Leu 
                325                 330                 335     


Gly Pro Pro Gly Asn Pro Gly Pro Ser Gly Ser Pro Gly Pro Lys Gly 
            340                 345                 350         


Gln Lys Gly Asp Pro Gly Lys Ser Pro Asp Gly Asp Ser Ser Leu Ala 
        355                 360                 365             


Ala Ser Glu Arg Lys Ala Leu Gln Thr Glu Met Ala Arg Ile Lys Lys 
    370                 375                 380                 


Trp Leu Thr Phe Ser Leu Gly Lys Gln Val Gly Asn Lys Phe Phe Leu 
385                 390                 395                 400 


Thr Asn Gly Glu Ile Met Thr Phe Glu Lys Val Lys Ala Leu Cys Val 
                405                 410                 415     


Lys Phe Gln Ala Ser Val Ala Thr Pro Arg Asn Ala Ala Glu Asn Gly 
            420                 425                 430         


Ala Ile Gln Asn Leu Ile Lys Glu Glu Ala Phe Leu Gly Ile Thr Asp 
        435                 440                 445             


Glu Lys Thr Glu Gly Gln Phe Val Asp Leu Thr Gly Asn Arg Leu Thr 
    450                 455                 460                 


Tyr Thr Asn Trp Asn Glu Gly Glu Pro Asn Asn Ala Gly Ser Asp Glu 
465                 470                 475                 480 


Asp Cys Val Leu Leu Leu Lys Asn Gly Gln Trp Asn Asp Val Pro Cys 
                485                 490                 495     


Ser Thr Ser His Leu Ala Val Cys Glu Phe Pro Ile Gly Gly Gly Gly 
            500                 505                 510         


Gly Gly Gly Gly Gly Gly Gly Gly Met Ser Leu Phe Pro Ser Leu Pro 
        515                 520                 525             


Leu Leu Leu Leu Ser Met Val Ala Ala Ser Tyr Ser Glu Thr Val Thr 
    530                 535                 540                 


Cys Glu Asp Ala Gln Lys Thr Cys Pro Ala Val Ile Ala Cys Ser Ser 
545                 550                 555                 560 


Pro Gly Ile Asn Gly Phe Pro Gly Lys Asp Gly Arg Asp Gly Thr Lys 
                565                 570                 575     


Gly Glu Lys Gly Glu Pro Gly Gln Gly Leu Arg Gly Leu Gln Gly Pro 
            580                 585                 590         


Pro Gly Lys Leu Gly Pro Pro Gly Asn Pro Gly Pro Ser Gly Ser Pro 
        595                 600                 605             


Gly Pro Lys Gly Gln Lys Gly Asp Pro Gly Lys Ser Pro Asp Gly Asp 
    610                 615                 620                 


Ser Ser Leu Ala Ala Ser Glu Arg Lys Ala Leu Gln Thr Glu Met Ala 
625                 630                 635                 640 


Arg Ile Lys Lys Trp Leu Thr Phe Ser Leu Gly Lys Gln Val Gly Asn 
                645                 650                 655     


Lys Phe Phe Leu Thr Asn Gly Glu Ile Met Thr Phe Glu Lys Val Lys 
            660                 665                 670         


Ala Leu Cys Val Lys Phe Gln Ala Ser Val Ala Thr Pro Arg Asn Ala 
        675                 680                 685             


Ala Glu Asn Gly Ala Ile Gln Asn Leu Ile Lys Glu Glu Ala Phe Leu 
    690                 695                 700                 


Gly Ile Thr Asp Glu Lys Thr Glu Gly Gln Phe Val Asp Leu Thr Gly 
705                 710                 715                 720 


Asn Arg Leu Thr Tyr Thr Asn Trp Asn Glu Gly Glu Pro Asn Asn Ala 
                725                 730                 735     


Gly Ser Asp Glu Asp Cys Val Leu Leu Leu Lys Asn Gly Gln Trp Asn 
            740                 745                 750         


Asp Val Pro Cys Ser Thr Ser His Leu Ala Val Cys Glu Phe Pro Ile 
        755                 760                 765             


Met Ser Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu Ser Met Val Ala 
    770                 775                 780                 


Ala Ser Tyr Ser Glu Thr Val Thr Cys Glu Asp Ala Gln Lys Thr Cys 
785                 790                 795                 800 


Pro Ala Val Ile Ala Cys Ser Ser Pro Gly Ile Asn Gly Phe Pro Gly 
                805                 810                 815     


Lys Asp Gly Arg Asp Gly Thr Lys Gly Glu Lys Gly Glu Pro Gly Gln 
            820                 825                 830         


Gly Leu Arg Gly Leu Gln Gly Pro Pro Gly Lys Leu Gly Pro Pro Gly 
        835                 840                 845             


Asn Pro Gly Pro Ser Gly Ser Pro Gly Pro Lys Gly Gln Lys Gly Asp 
    850                 855                 860                 


Pro Gly Lys Ser Pro Asp Gly Asp Ser Ser Leu Ala Ala Ser Glu Arg 
865                 870                 875                 880 


Lys Ala Leu Gln Thr Glu Met Ala Arg Ile Lys Lys Trp Leu Thr Phe 
                885                 890                 895     


Ser Leu Gly Lys Gln Val Gly Asn Lys Phe Phe Leu Thr Asn Gly Glu 
            900                 905                 910         


Ile Met Thr Phe Glu Lys Val Lys Ala Leu Cys Val Lys Phe Gln Ala 
        915                 920                 925             


Ser Val Ala Thr Pro Arg Asn Ala Ala Glu Asn Gly Ala Ile Gln Asn 
    930                 935                 940                 


Leu Ile Lys Glu Glu Ala Phe Leu Gly Ile Thr Asp Glu Lys Thr Glu 
945                 950                 955                 960 


Gly Gln Phe Val Asp Leu Thr Gly Asn Arg Leu Thr Tyr Thr Asn Trp 
                965                 970                 975     


Asn Glu Gly Glu Pro Asn Asn Ala Gly Ser Asp Glu Asp Cys Val Leu 
            980                 985                 990         


Leu Leu Lys Asn Gly Gln Trp Asn  Asp Val Pro Cys Ser  Thr Ser His 
        995                 1000                 1005             


Leu Ala  Val Cys Glu Phe Pro  Ile Met Arg Leu Leu  Thr Leu Leu 
    1010                 1015                 1020             


Gly Leu  Leu Cys Gly Ser Val  Ala Thr Pro Leu Gly  Pro Lys Trp 
    1025                 1030                 1035             


Pro Glu  Pro Val Phe Gly Arg  Leu Ala Ser Pro Gly  Phe Pro Gly 
    1040                 1045                 1050             


Glu Tyr  Ala Asn Asp Gln Glu  Arg Arg Trp Thr Leu  Thr Ala Pro 
    1055                 1060                 1065             


Pro Gly  Tyr Arg Leu Arg Leu  Tyr Phe Thr His Phe  Asp Leu Glu 
    1070                 1075                 1080             


Leu Ser  His Leu Cys Glu Tyr  Asp Phe Val Lys Leu  Ser Ser Gly 
    1085                 1090                 1095             


Ala Lys  Val Leu Ala Thr Leu  Cys Gly Gln Glu Ser  Thr Asp Thr 
    1100                 1105                 1110             


Glu Arg  Ala Pro Gly Lys Asp  Thr Phe Tyr Ser Leu  Gly Ser Ser 
    1115                 1120                 1125             


Leu Asp  Ile Thr Phe Arg Ser  Asp Tyr Ser Asn Glu  Lys Pro Phe 
    1130                 1135                 1140             


Thr Gly  Phe Glu Ala Phe Tyr  Ala Ala Glu Asp Ile  Asp Glu Cys 
    1145                 1150                 1155             


Gln Val  Ala Pro Gly Glu Ala  Pro Thr Cys Asp His  His Cys His 
    1160                 1165                 1170             


Asn His  Leu Gly Gly Phe Tyr  Cys Ser Cys Arg Ala  Gly Tyr Val 
    1175                 1180                 1185             


Leu His  Arg Asn Lys Arg Thr  Cys Ser Ala Leu Cys  Ser Gly Gln 
    1190                 1195                 1200             


Val Phe  Thr Gln Arg Ser Gly  Glu Leu Ser Ser Pro  Glu Tyr Pro 
    1205                 1210                 1215             


Arg Pro  Tyr Pro Lys Leu Ser  Ser Cys Thr Tyr Ser  Ile Ser Leu 
    1220                 1225                 1230             


Glu Glu  Gly Phe Ser Val Ile  Leu Asp Phe Val Glu  Ser Phe Asp 
    1235                 1240                 1245             


Val Glu  Thr His Pro Glu Thr  Leu Cys Pro Tyr Asp  Phe Leu Lys 
    1250                 1255                 1260             


Ile Gln  Thr Asp Arg Glu Glu  His Gly Pro Phe Cys  Gly Lys Thr 
    1265                 1270                 1275             


Leu Pro  His Arg Ile Glu Thr  Lys Ser Asn Thr Val  Thr Ile Thr 
    1280                 1285                 1290             


Phe Val  Thr Asp Glu Ser Gly  Asp His Thr Gly Trp  Lys Ile His 
    1295                 1300                 1305             


Tyr Thr  Ser Thr Ala Gln Pro  Cys Pro Tyr Pro Met  Ala Pro Pro 
    1310                 1315                 1320             


Asn Gly  His Val Ser Pro Val  Gln Ala Lys Tyr Ile  Leu Lys Asp 
    1325                 1330                 1335             


Ser Phe  Ser Ile Phe Cys Glu  Thr Gly Tyr Glu Leu  Leu Gln Gly 
    1340                 1345                 1350             


His Leu  Pro Leu Lys Ser Phe  Thr Ala Val Cys Gln  Lys Asp Gly 
    1355                 1360                 1365             


Ser Trp  Asp Arg Pro Met Pro  Ala Cys Ser Ile Val  Asp Cys Gly 
    1370                 1375                 1380             


Pro Pro  Asp Asp Leu Pro Ser  Gly Arg Val Glu Tyr  Ile Thr Gly 
    1385                 1390                 1395             


Pro Gly  Val Thr Thr Tyr Lys  Ala Val Ile Gln Tyr  Ser Cys Glu 
    1400                 1405                 1410             


Glu Thr  Phe Tyr Thr Met Lys  Val Asn Asp Gly Lys  Tyr Val Cys 
    1415                 1420                 1425             


Glu Ala  Asp Gly Phe Trp Thr  Ser Ser Lys Gly Glu  Lys Ser Leu 
    1430                 1435                 1440             


Pro Val  Cys Glu Pro Val Cys  Gly Leu Ser Ala Arg  Thr Thr Gly 
    1445                 1450                 1455             


Gly Arg  Ile Tyr Gly Gly Gln  Lys Ala Lys Pro Gly  Asp Phe Pro 
    1460                 1465                 1470             


Trp Gln  Val Leu Ile Leu Gly  Gly Thr Thr Ala Ala  Gly Ala Leu 
    1475                 1480                 1485             


Leu Tyr  Asp Asn Trp Val Leu  Thr Ala Ala His Ala  Val Tyr Glu 
    1490                 1495                 1500             


Gln Lys  His Asp Ala Ser Ala  Leu Asp Ile Arg Met  Gly Thr Leu 
    1505                 1510                 1515             


Lys Arg  Leu Ser Pro His Tyr  Thr Gln Ala Trp Ser  Glu Ala Val 
    1520                 1525                 1530             


Phe Ile  His Glu Gly Tyr Thr  His Asp Ala Gly Phe  Asp Asn Asp 
    1535                 1540                 1545             


Ile Ala  Leu Ile Lys Leu Asn  Asn Lys Val Val Ile  Asn Ser Asn 
    1550                 1555                 1560             


Ile Thr  Pro Ile Cys Leu Pro  Arg Lys Glu Ala Glu  Ser Phe Met 
    1565                 1570                 1575             


Arg Thr  Asp Asp Ile Gly Thr  Ala Ser Gly Trp Gly  Leu Thr Gln 
    1580                 1585                 1590             


Arg Gly  Phe Leu Ala Arg Asn  Leu Met Tyr Val Asp  Ile Pro Ile 
    1595                 1600                 1605             


Val Asp  His Gln Lys Cys Thr  Ala Ala Tyr Glu Lys  Pro Pro Tyr 
    1610                 1615                 1620             


Pro Arg  Gly Ser Val Thr Ala  Asn Met Leu Cys Ala  Gly Leu Glu 
    1625                 1630                 1635             


Ser Gly  Gly Lys Asp Ser Cys  Arg Gly Asp Ser Gly  Gly Ala Leu 
    1640                 1645                 1650             


Val Phe  Leu Asp Ser Glu Thr  Glu Arg Trp Phe Val  Gly Gly Ile 
    1655                 1660                 1665             


Val Ser  Trp Gly Ser Met Asn  Cys Gly Glu Ala Gly  Gln Tyr Gly 
    1670                 1675                 1680             


Val Tyr  Thr Lys Val Ile Asn  Tyr Ile Pro Trp Ile  Glu Asn Ile 
    1685                 1690                 1695             


Ile Ser  Asp Phe Met Arg Leu  Leu Thr Leu Leu Gly  Leu Leu Cys 
    1700                 1705                 1710             


Gly Ser  Val Ala Thr Pro Leu  Gly Pro Lys Trp Pro  Glu Pro Val 
    1715                 1720                 1725             


Phe Gly  Arg Leu Ala Ser Pro  Gly Phe Pro Gly Glu  Tyr Ala Asn 
    1730                 1735                 1740             


Asp Gln  Glu Arg Arg Trp Thr  Leu Thr Ala Pro Pro  Gly Tyr Arg 
    1745                 1750                 1755             


Leu Arg  Leu Tyr Phe Thr His  Phe Asp Leu Glu Leu  Ser His Leu 
    1760                 1765                 1770             


Cys Glu  Tyr Asp Phe Val Lys  Leu Ser Ser Gly Ala  Lys Val Leu 
    1775                 1780                 1785             


Ala Thr  Leu Cys Gly Gln Glu  Ser Thr Asp Thr Glu  Arg Ala Pro 
    1790                 1795                 1800             


Gly Lys  Asp Thr Phe Tyr Ser  Leu Gly Ser Ser Leu  Asp Ile Thr 
    1805                 1810                 1815             


Phe Arg  Ser Asp Tyr Ser Asn  Glu Lys Pro Phe Thr  Gly Phe Glu 
    1820                 1825                 1830             


Ala Phe  Tyr Ala Ala Glu Asp  Ile Asp Glu Cys Gln  Val Ala Pro 
    1835                 1840                 1845             


Gly Glu  Ala Pro Thr Cys Asp  His His Cys His Asn  His Leu Gly 
    1850                 1855                 1860             


Gly Phe  Tyr Cys Ser Cys Arg  Ala Gly Tyr Val Leu  His Arg Asn 
    1865                 1870                 1875             


Lys Arg  Thr Cys Ser Ala Leu  Cys Ser Gly Gln Val  Phe Thr Gln 
    1880                 1885                 1890             


Arg Ser  Gly Glu Leu Ser Ser  Pro Glu Tyr Pro Arg  Pro Tyr Pro 
    1895                 1900                 1905             


Lys Leu  Ser Ser Cys Thr Tyr  Ser Ile Ser Leu Glu  Glu Gly Phe 
    1910                 1915                 1920             


Ser Val  Ile Leu Asp Phe Val  Glu Ser Phe Asp Val  Glu Thr His 
    1925                 1930                 1935             


Pro Glu  Thr Leu Cys Pro Tyr  Asp Phe Leu Lys Ile  Gln Thr Asp 
    1940                 1945                 1950             


Arg Glu  Glu His Gly Pro Phe  Cys Gly Lys Thr Leu  Pro His Arg 
    1955                 1960                 1965             


Ile Glu  Thr Lys Ser Asn Thr  Val Thr Ile Thr Phe  Val Thr Asp 
    1970                 1975                 1980             


Glu Ser  Gly Asp His Thr Gly  Trp Lys Ile His Tyr  Thr Ser Thr 
    1985                 1990                 1995             


Ala Gln  Pro Cys Pro Tyr Pro  Met Ala Pro Pro Asn  Gly His Val 
    2000                 2005                 2010             


Ser Pro  Val Gln Ala Lys Tyr  Ile Leu Lys Asp Ser  Phe Ser Ile 
    2015                 2020                 2025             


Phe Cys  Glu Thr Gly Tyr Glu  Leu Leu Gln Gly His  Leu Pro Leu 
    2030                 2035                 2040             


Lys Ser  Phe Thr Ala Val Cys  Gln Lys Asp Gly Ser  Trp Asp Arg 
    2045                 2050                 2055             


Pro Met  Pro Ala Cys Ser Ile  Val Asp Cys Gly Pro  Pro Asp Asp 
    2060                 2065                 2070             


Leu Pro  Ser Gly Arg Val Glu  Tyr Ile Thr Gly Pro  Gly Val Thr 
    2075                 2080                 2085             


Thr Tyr  Lys Ala Val Ile Gln  Tyr Ser Cys Glu Glu  Thr Phe Tyr 
    2090                 2095                 2100             


Thr Met  Lys Val Asn Asp Gly  Lys Tyr Val Cys Glu  Ala Asp Gly 
    2105                 2110                 2115             


Phe Trp  Thr Ser Ser Lys Gly  Glu Lys Ser Leu Pro  Val Cys Glu 
    2120                 2125                 2130             


Pro Val  Cys Gly Leu Ser Ala  Arg Thr Thr Gly Gly  Arg Ile Tyr 
    2135                 2140                 2145             


Gly Gly  Gln Lys Ala Lys Pro  Gly Asp Phe Pro Trp  Gln Val Leu 
    2150                 2155                 2160             


Ile Leu  Gly Gly Thr Thr Ala  Ala Gly Ala Leu Leu  Tyr Asp Asn 
    2165                 2170                 2175             


Trp Val  Leu Thr Ala Ala His  Ala Val Tyr Glu Gln  Lys His Asp 
    2180                 2185                 2190             


Ala Ser  Ala Leu Asp Ile Arg  Met Gly Thr Leu Lys  Arg Leu Ser 
    2195                 2200                 2205             


Pro His  Tyr Thr Gln Ala Trp  Ser Glu Ala Val Phe  Ile His Glu 
    2210                 2215                 2220             


Gly Tyr  Thr His Asp Ala Gly  Phe Asp Asn Asp Ile  Ala Leu Ile 
    2225                 2230                 2235             


Lys Leu  Asn Asn Lys Val Val  Ile Asn Ser Asn Ile  Thr Pro Ile 
    2240                 2245                 2250             


Cys Leu  Pro Arg Lys Glu Ala  Glu Ser Phe Met Arg  Thr Asp Asp 
    2255                 2260                 2265             


Ile Gly  Thr Ala Ser Gly Trp  Gly Leu Thr Gln Arg  Gly Phe Leu 
    2270                 2275                 2280             


Ala Arg  Asn Leu Met Tyr Val  Asp Ile Pro Ile Val  Asp His Gln 
    2285                 2290                 2295             


Lys Cys  Thr Ala Ala Tyr Glu  Lys Pro Pro Tyr Pro  Arg Gly Ser 
    2300                 2305                 2310             


Val Thr  Ala Asn Met Leu Cys  Ala Gly Leu Glu Ser  Gly Gly Lys 
    2315                 2320                 2325             


Asp Ser  Cys Arg Gly Asp Ser  Gly Gly Ala Leu Val  Phe Leu Asp 
    2330                 2335                 2340             


Ser Glu  Thr Glu Arg Trp Phe  Val Gly Gly Ile Val  Ser Trp Gly 
    2345                 2350                 2355             


Ser Met  Asn Cys Gly Glu Ala  Gly Gln Tyr Gly Val  Tyr Thr Lys 
    2360                 2365                 2370             


Val Ile  Asn Tyr Ile Pro Trp  Ile Glu Asn Ile Ile  Ser Asp Phe 
    2375                 2380                 2385             


<210>  2
<211>  768
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary recombinant protein of the invention with the following
       domain configuration: MBL-2 - L - MBL-2 - L - MBL-2

<400>  2

Met Ser Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu Ser Met Val Ala 
1               5                   10                  15      


Ala Ser Tyr Ser Glu Thr Val Thr Cys Glu Asp Ala Gln Lys Thr Cys 
            20                  25                  30          


Pro Ala Val Ile Ala Cys Ser Ser Pro Gly Ile Asn Gly Phe Pro Gly 
        35                  40                  45              


Lys Asp Gly Arg Asp Gly Thr Lys Gly Glu Lys Gly Glu Pro Gly Gln 
    50                  55                  60                  


Gly Leu Arg Gly Leu Gln Gly Pro Pro Gly Lys Leu Gly Pro Pro Gly 
65                  70                  75                  80  


Asn Pro Gly Pro Ser Gly Ser Pro Gly Pro Lys Gly Gln Lys Gly Asp 
                85                  90                  95      


Pro Gly Lys Ser Pro Asp Gly Asp Ser Ser Leu Ala Ala Ser Glu Arg 
            100                 105                 110         


Lys Ala Leu Gln Thr Glu Met Ala Arg Ile Lys Lys Trp Leu Thr Phe 
        115                 120                 125             


Ser Leu Gly Lys Gln Val Gly Asn Lys Phe Phe Leu Thr Asn Gly Glu 
    130                 135                 140                 


Ile Met Thr Phe Glu Lys Val Lys Ala Leu Cys Val Lys Phe Gln Ala 
145                 150                 155                 160 


Ser Val Ala Thr Pro Arg Asn Ala Ala Glu Asn Gly Ala Ile Gln Asn 
                165                 170                 175     


Leu Ile Lys Glu Glu Ala Phe Leu Gly Ile Thr Asp Glu Lys Thr Glu 
            180                 185                 190         


Gly Gln Phe Val Asp Leu Thr Gly Asn Arg Leu Thr Tyr Thr Asn Trp 
        195                 200                 205             


Asn Glu Gly Glu Pro Asn Asn Ala Gly Ser Asp Glu Asp Cys Val Leu 
    210                 215                 220                 


Leu Leu Lys Asn Gly Gln Trp Asn Asp Val Pro Cys Ser Thr Ser His 
225                 230                 235                 240 


Leu Ala Val Cys Glu Phe Pro Ile Gly Gly Gly Gly Gly Gly Gly Gly 
                245                 250                 255     


Gly Gly Gly Gly Met Ser Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu 
            260                 265                 270         


Ser Met Val Ala Ala Ser Tyr Ser Glu Thr Val Thr Cys Glu Asp Ala 
        275                 280                 285             


Gln Lys Thr Cys Pro Ala Val Ile Ala Cys Ser Ser Pro Gly Ile Asn 
    290                 295                 300                 


Gly Phe Pro Gly Lys Asp Gly Arg Asp Gly Thr Lys Gly Glu Lys Gly 
305                 310                 315                 320 


Glu Pro Gly Gln Gly Leu Arg Gly Leu Gln Gly Pro Pro Gly Lys Leu 
                325                 330                 335     


Gly Pro Pro Gly Asn Pro Gly Pro Ser Gly Ser Pro Gly Pro Lys Gly 
            340                 345                 350         


Gln Lys Gly Asp Pro Gly Lys Ser Pro Asp Gly Asp Ser Ser Leu Ala 
        355                 360                 365             


Ala Ser Glu Arg Lys Ala Leu Gln Thr Glu Met Ala Arg Ile Lys Lys 
    370                 375                 380                 


Trp Leu Thr Phe Ser Leu Gly Lys Gln Val Gly Asn Lys Phe Phe Leu 
385                 390                 395                 400 


Thr Asn Gly Glu Ile Met Thr Phe Glu Lys Val Lys Ala Leu Cys Val 
                405                 410                 415     


Lys Phe Gln Ala Ser Val Ala Thr Pro Arg Asn Ala Ala Glu Asn Gly 
            420                 425                 430         


Ala Ile Gln Asn Leu Ile Lys Glu Glu Ala Phe Leu Gly Ile Thr Asp 
        435                 440                 445             


Glu Lys Thr Glu Gly Gln Phe Val Asp Leu Thr Gly Asn Arg Leu Thr 
    450                 455                 460                 


Tyr Thr Asn Trp Asn Glu Gly Glu Pro Asn Asn Ala Gly Ser Asp Glu 
465                 470                 475                 480 


Asp Cys Val Leu Leu Leu Lys Asn Gly Gln Trp Asn Asp Val Pro Cys 
                485                 490                 495     


Ser Thr Ser His Leu Ala Val Cys Glu Phe Pro Ile Gly Gly Gly Gly 
            500                 505                 510         


Gly Gly Gly Gly Gly Gly Gly Gly Met Ser Leu Phe Pro Ser Leu Pro 
        515                 520                 525             


Leu Leu Leu Leu Ser Met Val Ala Ala Ser Tyr Ser Glu Thr Val Thr 
    530                 535                 540                 


Cys Glu Asp Ala Gln Lys Thr Cys Pro Ala Val Ile Ala Cys Ser Ser 
545                 550                 555                 560 


Pro Gly Ile Asn Gly Phe Pro Gly Lys Asp Gly Arg Asp Gly Thr Lys 
                565                 570                 575     


Gly Glu Lys Gly Glu Pro Gly Gln Gly Leu Arg Gly Leu Gln Gly Pro 
            580                 585                 590         


Pro Gly Lys Leu Gly Pro Pro Gly Asn Pro Gly Pro Ser Gly Ser Pro 
        595                 600                 605             


Gly Pro Lys Gly Gln Lys Gly Asp Pro Gly Lys Ser Pro Asp Gly Asp 
    610                 615                 620                 


Ser Ser Leu Ala Ala Ser Glu Arg Lys Ala Leu Gln Thr Glu Met Ala 
625                 630                 635                 640 


Arg Ile Lys Lys Trp Leu Thr Phe Ser Leu Gly Lys Gln Val Gly Asn 
                645                 650                 655     


Lys Phe Phe Leu Thr Asn Gly Glu Ile Met Thr Phe Glu Lys Val Lys 
            660                 665                 670         


Ala Leu Cys Val Lys Phe Gln Ala Ser Val Ala Thr Pro Arg Asn Ala 
        675                 680                 685             


Ala Glu Asn Gly Ala Ile Gln Asn Leu Ile Lys Glu Glu Ala Phe Leu 
    690                 695                 700                 


Gly Ile Thr Asp Glu Lys Thr Glu Gly Gln Phe Val Asp Leu Thr Gly 
705                 710                 715                 720 


Asn Arg Leu Thr Tyr Thr Asn Trp Asn Glu Gly Glu Pro Asn Asn Ala 
                725                 730                 735     


Gly Ser Asp Glu Asp Cys Val Leu Leu Leu Lys Asn Gly Gln Trp Asn 
            740                 745                 750         


Asp Val Pro Cys Ser Thr Ser His Leu Ala Val Cys Glu Phe Pro Ile 
        755                 760                 765             


<210>  3
<211>  2164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary recombinant protein of the invention with the following
       domain configuration: MBL-2 - L - MBL-2 - L - MBL-2 - L - MASP-2 
       - L - MASP2

<400>  3

Met Ser Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu Ser Met Val Ala 
1               5                   10                  15      


Ala Ser Tyr Ser Glu Thr Val Thr Cys Glu Asp Ala Gln Lys Thr Cys 
            20                  25                  30          


Pro Ala Val Ile Ala Cys Ser Ser Pro Gly Ile Asn Gly Phe Pro Gly 
        35                  40                  45              


Lys Asp Gly Arg Asp Gly Thr Lys Gly Glu Lys Gly Glu Pro Gly Gln 
    50                  55                  60                  


Gly Leu Arg Gly Leu Gln Gly Pro Pro Gly Lys Leu Gly Pro Pro Gly 
65                  70                  75                  80  


Asn Pro Gly Pro Ser Gly Ser Pro Gly Pro Lys Gly Gln Lys Gly Asp 
                85                  90                  95      


Pro Gly Lys Ser Pro Asp Gly Asp Ser Ser Leu Ala Ala Ser Glu Arg 
            100                 105                 110         


Lys Ala Leu Gln Thr Glu Met Ala Arg Ile Lys Lys Trp Leu Thr Phe 
        115                 120                 125             


Ser Leu Gly Lys Gln Val Gly Asn Lys Phe Phe Leu Thr Asn Gly Glu 
    130                 135                 140                 


Ile Met Thr Phe Glu Lys Val Lys Ala Leu Cys Val Lys Phe Gln Ala 
145                 150                 155                 160 


Ser Val Ala Thr Pro Arg Asn Ala Ala Glu Asn Gly Ala Ile Gln Asn 
                165                 170                 175     


Leu Ile Lys Glu Glu Ala Phe Leu Gly Ile Thr Asp Glu Lys Thr Glu 
            180                 185                 190         


Gly Gln Phe Val Asp Leu Thr Gly Asn Arg Leu Thr Tyr Thr Asn Trp 
        195                 200                 205             


Asn Glu Gly Glu Pro Asn Asn Ala Gly Ser Asp Glu Asp Cys Val Leu 
    210                 215                 220                 


Leu Leu Lys Asn Gly Gln Trp Asn Asp Val Pro Cys Ser Thr Ser His 
225                 230                 235                 240 


Leu Ala Val Cys Glu Phe Pro Ile Gly Gly Gly Gly Gly Gly Gly Gly 
                245                 250                 255     


Gly Gly Gly Gly Met Ser Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu 
            260                 265                 270         


Ser Met Val Ala Ala Ser Tyr Ser Glu Thr Val Thr Cys Glu Asp Ala 
        275                 280                 285             


Gln Lys Thr Cys Pro Ala Val Ile Ala Cys Ser Ser Pro Gly Ile Asn 
    290                 295                 300                 


Gly Phe Pro Gly Lys Asp Gly Arg Asp Gly Thr Lys Gly Glu Lys Gly 
305                 310                 315                 320 


Glu Pro Gly Gln Gly Leu Arg Gly Leu Gln Gly Pro Pro Gly Lys Leu 
                325                 330                 335     


Gly Pro Pro Gly Asn Pro Gly Pro Ser Gly Ser Pro Gly Pro Lys Gly 
            340                 345                 350         


Gln Lys Gly Asp Pro Gly Lys Ser Pro Asp Gly Asp Ser Ser Leu Ala 
        355                 360                 365             


Ala Ser Glu Arg Lys Ala Leu Gln Thr Glu Met Ala Arg Ile Lys Lys 
    370                 375                 380                 


Trp Leu Thr Phe Ser Leu Gly Lys Gln Val Gly Asn Lys Phe Phe Leu 
385                 390                 395                 400 


Thr Asn Gly Glu Ile Met Thr Phe Glu Lys Val Lys Ala Leu Cys Val 
                405                 410                 415     


Lys Phe Gln Ala Ser Val Ala Thr Pro Arg Asn Ala Ala Glu Asn Gly 
            420                 425                 430         


Ala Ile Gln Asn Leu Ile Lys Glu Glu Ala Phe Leu Gly Ile Thr Asp 
        435                 440                 445             


Glu Lys Thr Glu Gly Gln Phe Val Asp Leu Thr Gly Asn Arg Leu Thr 
    450                 455                 460                 


Tyr Thr Asn Trp Asn Glu Gly Glu Pro Asn Asn Ala Gly Ser Asp Glu 
465                 470                 475                 480 


Asp Cys Val Leu Leu Leu Lys Asn Gly Gln Trp Asn Asp Val Pro Cys 
                485                 490                 495     


Ser Thr Ser His Leu Ala Val Cys Glu Phe Pro Ile Gly Gly Gly Gly 
            500                 505                 510         


Gly Gly Gly Gly Gly Gly Gly Gly Met Ser Leu Phe Pro Ser Leu Pro 
        515                 520                 525             


Leu Leu Leu Leu Ser Met Val Ala Ala Ser Tyr Ser Glu Thr Val Thr 
    530                 535                 540                 


Cys Glu Asp Ala Gln Lys Thr Cys Pro Ala Val Ile Ala Cys Ser Ser 
545                 550                 555                 560 


Pro Gly Ile Asn Gly Phe Pro Gly Lys Asp Gly Arg Asp Gly Thr Lys 
                565                 570                 575     


Gly Glu Lys Gly Glu Pro Gly Gln Gly Leu Arg Gly Leu Gln Gly Pro 
            580                 585                 590         


Pro Gly Lys Leu Gly Pro Pro Gly Asn Pro Gly Pro Ser Gly Ser Pro 
        595                 600                 605             


Gly Pro Lys Gly Gln Lys Gly Asp Pro Gly Lys Ser Pro Asp Gly Asp 
    610                 615                 620                 


Ser Ser Leu Ala Ala Ser Glu Arg Lys Ala Leu Gln Thr Glu Met Ala 
625                 630                 635                 640 


Arg Ile Lys Lys Trp Leu Thr Phe Ser Leu Gly Lys Gln Val Gly Asn 
                645                 650                 655     


Lys Phe Phe Leu Thr Asn Gly Glu Ile Met Thr Phe Glu Lys Val Lys 
            660                 665                 670         


Ala Leu Cys Val Lys Phe Gln Ala Ser Val Ala Thr Pro Arg Asn Ala 
        675                 680                 685             


Ala Glu Asn Gly Ala Ile Gln Asn Leu Ile Lys Glu Glu Ala Phe Leu 
    690                 695                 700                 


Gly Ile Thr Asp Glu Lys Thr Glu Gly Gln Phe Val Asp Leu Thr Gly 
705                 710                 715                 720 


Asn Arg Leu Thr Tyr Thr Asn Trp Asn Glu Gly Glu Pro Asn Asn Ala 
                725                 730                 735     


Gly Ser Asp Glu Asp Cys Val Leu Leu Leu Lys Asn Gly Gln Trp Asn 
            740                 745                 750         


Asp Val Pro Cys Ser Thr Ser His Leu Ala Val Cys Glu Phe Pro Ile 
        755                 760                 765             


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Met Arg Leu Leu 
    770                 775                 780                 


Thr Leu Leu Gly Leu Leu Cys Gly Ser Val Ala Thr Pro Leu Gly Pro 
785                 790                 795                 800 


Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala Ser Pro Gly Phe Pro 
                805                 810                 815     


Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp Thr Leu Thr Ala Pro 
            820                 825                 830         


Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe Asp Leu Glu Leu 
        835                 840                 845             


Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu Ser Ser Gly Ala Lys 
    850                 855                 860                 


Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp Thr Glu Arg Ala 
865                 870                 875                 880 


Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser Ser Leu Asp Ile Thr 
                885                 890                 895     


Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr Gly Phe Glu Ala 
            900                 905                 910         


Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln Val Ala Pro Gly Glu 
        915                 920                 925             


Ala Pro Thr Cys Asp His His Cys His Asn His Leu Gly Gly Phe Tyr 
    930                 935                 940                 


Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg Asn Lys Arg Thr Cys 
945                 950                 955                 960 


Ser Ala Leu Cys Ser Gly Gln Val Phe Thr Gln Arg Ser Gly Glu Leu 
                965                 970                 975     


Ser Ser Pro Glu Tyr Pro Arg Pro Tyr Pro Lys Leu Ser Ser Cys Thr 
            980                 985                 990         


Tyr Ser Ile Ser Leu Glu Glu Gly  Phe Ser Val Ile Leu  Asp Phe Val 
        995                 1000                 1005             


Glu Ser  Phe Asp Val Glu Thr  His Pro Glu Thr Leu  Cys Pro Tyr 
    1010                 1015                 1020             


Asp Phe  Leu Lys Ile Gln Thr  Asp Arg Glu Glu His  Gly Pro Phe 
    1025                 1030                 1035             


Cys Gly  Lys Thr Leu Pro His  Arg Ile Glu Thr Lys  Ser Asn Thr 
    1040                 1045                 1050             


Val Thr  Ile Thr Phe Val Thr  Asp Glu Ser Gly Asp  His Thr Gly 
    1055                 1060                 1065             


Trp Lys  Ile His Tyr Thr Ser  Thr Ala Gln Pro Cys  Pro Tyr Pro 
    1070                 1075                 1080             


Met Ala  Pro Pro Asn Gly His  Val Ser Pro Val Gln  Ala Lys Tyr 
    1085                 1090                 1095             


Ile Leu  Lys Asp Ser Phe Ser  Ile Phe Cys Glu Thr  Gly Tyr Glu 
    1100                 1105                 1110             


Leu Leu  Gln Gly His Leu Pro  Leu Lys Ser Phe Thr  Ala Val Cys 
    1115                 1120                 1125             


Gln Lys  Asp Gly Ser Trp Asp  Arg Pro Met Pro Ala  Cys Ser Ile 
    1130                 1135                 1140             


Val Asp  Cys Gly Pro Pro Asp  Asp Leu Pro Ser Gly  Arg Val Glu 
    1145                 1150                 1155             


Tyr Ile  Thr Gly Pro Gly Val  Thr Thr Tyr Lys Ala  Val Ile Gln 
    1160                 1165                 1170             


Tyr Ser  Cys Glu Glu Thr Phe  Tyr Thr Met Lys Val  Asn Asp Gly 
    1175                 1180                 1185             


Lys Tyr  Val Cys Glu Ala Asp  Gly Phe Trp Thr Ser  Ser Lys Gly 
    1190                 1195                 1200             


Glu Lys  Ser Leu Pro Val Cys  Glu Pro Val Cys Gly  Leu Ser Ala 
    1205                 1210                 1215             


Arg Thr  Thr Gly Gly Arg Ile  Tyr Gly Gly Gln Lys  Ala Lys Pro 
    1220                 1225                 1230             


Gly Asp  Phe Pro Trp Gln Val  Leu Ile Leu Gly Gly  Thr Thr Ala 
    1235                 1240                 1245             


Ala Gly  Ala Leu Leu Tyr Asp  Asn Trp Val Leu Thr  Ala Ala His 
    1250                 1255                 1260             


Ala Val  Tyr Glu Gln Lys His  Asp Ala Ser Ala Leu  Asp Ile Arg 
    1265                 1270                 1275             


Met Gly  Thr Leu Lys Arg Leu  Ser Pro His Tyr Thr  Gln Ala Trp 
    1280                 1285                 1290             


Ser Glu  Ala Val Phe Ile His  Glu Gly Tyr Thr His  Asp Ala Gly 
    1295                 1300                 1305             


Phe Asp  Asn Asp Ile Ala Leu  Ile Lys Leu Asn Asn  Lys Val Val 
    1310                 1315                 1320             


Ile Asn  Ser Asn Ile Thr Pro  Ile Cys Leu Pro Arg  Lys Glu Ala 
    1325                 1330                 1335             


Glu Ser  Phe Met Arg Thr Asp  Asp Ile Gly Thr Ala  Ser Gly Trp 
    1340                 1345                 1350             


Gly Leu  Thr Gln Arg Gly Phe  Leu Ala Arg Asn Leu  Met Tyr Val 
    1355                 1360                 1365             


Asp Ile  Pro Ile Val Asp His  Gln Lys Cys Thr Ala  Ala Tyr Glu 
    1370                 1375                 1380             


Lys Pro  Pro Tyr Pro Arg Gly  Ser Val Thr Ala Asn  Met Leu Cys 
    1385                 1390                 1395             


Ala Gly  Leu Glu Ser Gly Gly  Lys Asp Ser Cys Arg  Gly Asp Ser 
    1400                 1405                 1410             


Gly Gly  Ala Leu Val Phe Leu  Asp Ser Glu Thr Glu  Arg Trp Phe 
    1415                 1420                 1425             


Val Gly  Gly Ile Val Ser Trp  Gly Ser Met Asn Cys  Gly Glu Ala 
    1430                 1435                 1440             


Gly Gln  Tyr Gly Val Tyr Thr  Lys Val Ile Asn Tyr  Ile Pro Trp 
    1445                 1450                 1455             


Ile Glu  Asn Ile Ile Ser Asp  Phe Gly Gly Gly Gly  Gly Gly Gly 
    1460                 1465                 1470             


Gly Gly  Gly Gly Gly Met Arg  Leu Leu Thr Leu Leu  Gly Leu Leu 
    1475                 1480                 1485             


Cys Gly  Ser Val Ala Thr Pro  Leu Gly Pro Lys Trp  Pro Glu Pro 
    1490                 1495                 1500             


Val Phe  Gly Arg Leu Ala Ser  Pro Gly Phe Pro Gly  Glu Tyr Ala 
    1505                 1510                 1515             


Asn Asp  Gln Glu Arg Arg Trp  Thr Leu Thr Ala Pro  Pro Gly Tyr 
    1520                 1525                 1530             


Arg Leu  Arg Leu Tyr Phe Thr  His Phe Asp Leu Glu  Leu Ser His 
    1535                 1540                 1545             


Leu Cys  Glu Tyr Asp Phe Val  Lys Leu Ser Ser Gly  Ala Lys Val 
    1550                 1555                 1560             


Leu Ala  Thr Leu Cys Gly Gln  Glu Ser Thr Asp Thr  Glu Arg Ala 
    1565                 1570                 1575             


Pro Gly  Lys Asp Thr Phe Tyr  Ser Leu Gly Ser Ser  Leu Asp Ile 
    1580                 1585                 1590             


Thr Phe  Arg Ser Asp Tyr Ser  Asn Glu Lys Pro Phe  Thr Gly Phe 
    1595                 1600                 1605             


Glu Ala  Phe Tyr Ala Ala Glu  Asp Ile Asp Glu Cys  Gln Val Ala 
    1610                 1615                 1620             


Pro Gly  Glu Ala Pro Thr Cys  Asp His His Cys His  Asn His Leu 
    1625                 1630                 1635             


Gly Gly  Phe Tyr Cys Ser Cys  Arg Ala Gly Tyr Val  Leu His Arg 
    1640                 1645                 1650             


Asn Lys  Arg Thr Cys Ser Ala  Leu Cys Ser Gly Gln  Val Phe Thr 
    1655                 1660                 1665             


Gln Arg  Ser Gly Glu Leu Ser  Ser Pro Glu Tyr Pro  Arg Pro Tyr 
    1670                 1675                 1680             


Pro Lys  Leu Ser Ser Cys Thr  Tyr Ser Ile Ser Leu  Glu Glu Gly 
    1685                 1690                 1695             


Phe Ser  Val Ile Leu Asp Phe  Val Glu Ser Phe Asp  Val Glu Thr 
    1700                 1705                 1710             


His Pro  Glu Thr Leu Cys Pro  Tyr Asp Phe Leu Lys  Ile Gln Thr 
    1715                 1720                 1725             


Asp Arg  Glu Glu His Gly Pro  Phe Cys Gly Lys Thr  Leu Pro His 
    1730                 1735                 1740             


Arg Ile  Glu Thr Lys Ser Asn  Thr Val Thr Ile Thr  Phe Val Thr 
    1745                 1750                 1755             


Asp Glu  Ser Gly Asp His Thr  Gly Trp Lys Ile His  Tyr Thr Ser 
    1760                 1765                 1770             


Thr Ala  Gln Pro Cys Pro Tyr  Pro Met Ala Pro Pro  Asn Gly His 
    1775                 1780                 1785             


Val Ser  Pro Val Gln Ala Lys  Tyr Ile Leu Lys Asp  Ser Phe Ser 
    1790                 1795                 1800             


Ile Phe  Cys Glu Thr Gly Tyr  Glu Leu Leu Gln Gly  His Leu Pro 
    1805                 1810                 1815             


Leu Lys  Ser Phe Thr Ala Val  Cys Gln Lys Asp Gly  Ser Trp Asp 
    1820                 1825                 1830             


Arg Pro  Met Pro Ala Cys Ser  Ile Val Asp Cys Gly  Pro Pro Asp 
    1835                 1840                 1845             


Asp Leu  Pro Ser Gly Arg Val  Glu Tyr Ile Thr Gly  Pro Gly Val 
    1850                 1855                 1860             


Thr Thr  Tyr Lys Ala Val Ile  Gln Tyr Ser Cys Glu  Glu Thr Phe 
    1865                 1870                 1875             


Tyr Thr  Met Lys Val Asn Asp  Gly Lys Tyr Val Cys  Glu Ala Asp 
    1880                 1885                 1890             


Gly Phe  Trp Thr Ser Ser Lys  Gly Glu Lys Ser Leu  Pro Val Cys 
    1895                 1900                 1905             


Glu Pro  Val Cys Gly Leu Ser  Ala Arg Thr Thr Gly  Gly Arg Ile 
    1910                 1915                 1920             


Tyr Gly  Gly Gln Lys Ala Lys  Pro Gly Asp Phe Pro  Trp Gln Val 
    1925                 1930                 1935             


Leu Ile  Leu Gly Gly Thr Thr  Ala Ala Gly Ala Leu  Leu Tyr Asp 
    1940                 1945                 1950             


Asn Trp  Val Leu Thr Ala Ala  His Ala Val Tyr Glu  Gln Lys His 
    1955                 1960                 1965             


Asp Ala  Ser Ala Leu Asp Ile  Arg Met Gly Thr Leu  Lys Arg Leu 
    1970                 1975                 1980             


Ser Pro  His Tyr Thr Gln Ala  Trp Ser Glu Ala Val  Phe Ile His 
    1985                 1990                 1995             


Glu Gly  Tyr Thr His Asp Ala  Gly Phe Asp Asn Asp  Ile Ala Leu 
    2000                 2005                 2010             


Ile Lys  Leu Asn Asn Lys Val  Val Ile Asn Ser Asn  Ile Thr Pro 
    2015                 2020                 2025             


Ile Cys  Leu Pro Arg Lys Glu  Ala Glu Ser Phe Met  Arg Thr Asp 
    2030                 2035                 2040             


Asp Ile  Gly Thr Ala Ser Gly  Trp Gly Leu Thr Gln  Arg Gly Phe 
    2045                 2050                 2055             


Leu Ala  Arg Asn Leu Met Tyr  Val Asp Ile Pro Ile  Val Asp His 
    2060                 2065                 2070             


Gln Lys  Cys Thr Ala Ala Tyr  Glu Lys Pro Pro Tyr  Pro Arg Gly 
    2075                 2080                 2085             


Ser Val  Thr Ala Asn Met Leu  Cys Ala Gly Leu Glu  Ser Gly Gly 
    2090                 2095                 2100             


Lys Asp  Ser Cys Arg Gly Asp  Ser Gly Gly Ala Leu  Val Phe Leu 
    2105                 2110                 2115             


Asp Ser  Glu Thr Glu Arg Trp  Phe Val Gly Gly Ile  Val Ser Trp 
    2120                 2125                 2130             


Gly Ser  Met Asn Cys Gly Glu  Ala Gly Gln Tyr Gly  Val Tyr Thr 
    2135                 2140                 2145             


Lys Val  Ile Asn Tyr Ile Pro  Trp Ile Glu Asn Ile  Ile Ser Asp 
    2150                 2155                 2160             


Phe 
    


<210>  4
<211>  1466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary recombinant protein of the invention with the following
       domain configuration: MBL-2 - L - MBL-2 - L - MBL-2 - L - MASP2

<400>  4

Met Ser Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu Ser Met Val Ala 
1               5                   10                  15      


Ala Ser Tyr Ser Glu Thr Val Thr Cys Glu Asp Ala Gln Lys Thr Cys 
            20                  25                  30          


Pro Ala Val Ile Ala Cys Ser Ser Pro Gly Ile Asn Gly Phe Pro Gly 
        35                  40                  45              


Lys Asp Gly Arg Asp Gly Thr Lys Gly Glu Lys Gly Glu Pro Gly Gln 
    50                  55                  60                  


Gly Leu Arg Gly Leu Gln Gly Pro Pro Gly Lys Leu Gly Pro Pro Gly 
65                  70                  75                  80  


Asn Pro Gly Pro Ser Gly Ser Pro Gly Pro Lys Gly Gln Lys Gly Asp 
                85                  90                  95      


Pro Gly Lys Ser Pro Asp Gly Asp Ser Ser Leu Ala Ala Ser Glu Arg 
            100                 105                 110         


Lys Ala Leu Gln Thr Glu Met Ala Arg Ile Lys Lys Trp Leu Thr Phe 
        115                 120                 125             


Ser Leu Gly Lys Gln Val Gly Asn Lys Phe Phe Leu Thr Asn Gly Glu 
    130                 135                 140                 


Ile Met Thr Phe Glu Lys Val Lys Ala Leu Cys Val Lys Phe Gln Ala 
145                 150                 155                 160 


Ser Val Ala Thr Pro Arg Asn Ala Ala Glu Asn Gly Ala Ile Gln Asn 
                165                 170                 175     


Leu Ile Lys Glu Glu Ala Phe Leu Gly Ile Thr Asp Glu Lys Thr Glu 
            180                 185                 190         


Gly Gln Phe Val Asp Leu Thr Gly Asn Arg Leu Thr Tyr Thr Asn Trp 
        195                 200                 205             


Asn Glu Gly Glu Pro Asn Asn Ala Gly Ser Asp Glu Asp Cys Val Leu 
    210                 215                 220                 


Leu Leu Lys Asn Gly Gln Trp Asn Asp Val Pro Cys Ser Thr Ser His 
225                 230                 235                 240 


Leu Ala Val Cys Glu Phe Pro Ile Gly Gly Gly Gly Gly Gly Gly Gly 
                245                 250                 255     


Gly Gly Gly Gly Met Ser Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu 
            260                 265                 270         


Ser Met Val Ala Ala Ser Tyr Ser Glu Thr Val Thr Cys Glu Asp Ala 
        275                 280                 285             


Gln Lys Thr Cys Pro Ala Val Ile Ala Cys Ser Ser Pro Gly Ile Asn 
    290                 295                 300                 


Gly Phe Pro Gly Lys Asp Gly Arg Asp Gly Thr Lys Gly Glu Lys Gly 
305                 310                 315                 320 


Glu Pro Gly Gln Gly Leu Arg Gly Leu Gln Gly Pro Pro Gly Lys Leu 
                325                 330                 335     


Gly Pro Pro Gly Asn Pro Gly Pro Ser Gly Ser Pro Gly Pro Lys Gly 
            340                 345                 350         


Gln Lys Gly Asp Pro Gly Lys Ser Pro Asp Gly Asp Ser Ser Leu Ala 
        355                 360                 365             


Ala Ser Glu Arg Lys Ala Leu Gln Thr Glu Met Ala Arg Ile Lys Lys 
    370                 375                 380                 


Trp Leu Thr Phe Ser Leu Gly Lys Gln Val Gly Asn Lys Phe Phe Leu 
385                 390                 395                 400 


Thr Asn Gly Glu Ile Met Thr Phe Glu Lys Val Lys Ala Leu Cys Val 
                405                 410                 415     


Lys Phe Gln Ala Ser Val Ala Thr Pro Arg Asn Ala Ala Glu Asn Gly 
            420                 425                 430         


Ala Ile Gln Asn Leu Ile Lys Glu Glu Ala Phe Leu Gly Ile Thr Asp 
        435                 440                 445             


Glu Lys Thr Glu Gly Gln Phe Val Asp Leu Thr Gly Asn Arg Leu Thr 
    450                 455                 460                 


Tyr Thr Asn Trp Asn Glu Gly Glu Pro Asn Asn Ala Gly Ser Asp Glu 
465                 470                 475                 480 


Asp Cys Val Leu Leu Leu Lys Asn Gly Gln Trp Asn Asp Val Pro Cys 
                485                 490                 495     


Ser Thr Ser His Leu Ala Val Cys Glu Phe Pro Ile Gly Gly Gly Gly 
            500                 505                 510         


Gly Gly Gly Gly Gly Gly Gly Gly Met Ser Leu Phe Pro Ser Leu Pro 
        515                 520                 525             


Leu Leu Leu Leu Ser Met Val Ala Ala Ser Tyr Ser Glu Thr Val Thr 
    530                 535                 540                 


Cys Glu Asp Ala Gln Lys Thr Cys Pro Ala Val Ile Ala Cys Ser Ser 
545                 550                 555                 560 


Pro Gly Ile Asn Gly Phe Pro Gly Lys Asp Gly Arg Asp Gly Thr Lys 
                565                 570                 575     


Gly Glu Lys Gly Glu Pro Gly Gln Gly Leu Arg Gly Leu Gln Gly Pro 
            580                 585                 590         


Pro Gly Lys Leu Gly Pro Pro Gly Asn Pro Gly Pro Ser Gly Ser Pro 
        595                 600                 605             


Gly Pro Lys Gly Gln Lys Gly Asp Pro Gly Lys Ser Pro Asp Gly Asp 
    610                 615                 620                 


Ser Ser Leu Ala Ala Ser Glu Arg Lys Ala Leu Gln Thr Glu Met Ala 
625                 630                 635                 640 


Arg Ile Lys Lys Trp Leu Thr Phe Ser Leu Gly Lys Gln Val Gly Asn 
                645                 650                 655     


Lys Phe Phe Leu Thr Asn Gly Glu Ile Met Thr Phe Glu Lys Val Lys 
            660                 665                 670         


Ala Leu Cys Val Lys Phe Gln Ala Ser Val Ala Thr Pro Arg Asn Ala 
        675                 680                 685             


Ala Glu Asn Gly Ala Ile Gln Asn Leu Ile Lys Glu Glu Ala Phe Leu 
    690                 695                 700                 


Gly Ile Thr Asp Glu Lys Thr Glu Gly Gln Phe Val Asp Leu Thr Gly 
705                 710                 715                 720 


Asn Arg Leu Thr Tyr Thr Asn Trp Asn Glu Gly Glu Pro Asn Asn Ala 
                725                 730                 735     


Gly Ser Asp Glu Asp Cys Val Leu Leu Leu Lys Asn Gly Gln Trp Asn 
            740                 745                 750         


Asp Val Pro Cys Ser Thr Ser His Leu Ala Val Cys Glu Phe Pro Ile 
        755                 760                 765             


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Met Arg Leu Leu 
    770                 775                 780                 


Thr Leu Leu Gly Leu Leu Cys Gly Ser Val Ala Thr Pro Leu Gly Pro 
785                 790                 795                 800 


Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala Ser Pro Gly Phe Pro 
                805                 810                 815     


Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp Thr Leu Thr Ala Pro 
            820                 825                 830         


Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe Asp Leu Glu Leu 
        835                 840                 845             


Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu Ser Ser Gly Ala Lys 
    850                 855                 860                 


Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp Thr Glu Arg Ala 
865                 870                 875                 880 


Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser Ser Leu Asp Ile Thr 
                885                 890                 895     


Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr Gly Phe Glu Ala 
            900                 905                 910         


Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln Val Ala Pro Gly Glu 
        915                 920                 925             


Ala Pro Thr Cys Asp His His Cys His Asn His Leu Gly Gly Phe Tyr 
    930                 935                 940                 


Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg Asn Lys Arg Thr Cys 
945                 950                 955                 960 


Ser Ala Leu Cys Ser Gly Gln Val Phe Thr Gln Arg Ser Gly Glu Leu 
                965                 970                 975     


Ser Ser Pro Glu Tyr Pro Arg Pro Tyr Pro Lys Leu Ser Ser Cys Thr 
            980                 985                 990         


Tyr Ser Ile Ser Leu Glu Glu Gly  Phe Ser Val Ile Leu  Asp Phe Val 
        995                 1000                 1005             


Glu Ser  Phe Asp Val Glu Thr  His Pro Glu Thr Leu  Cys Pro Tyr 
    1010                 1015                 1020             


Asp Phe  Leu Lys Ile Gln Thr  Asp Arg Glu Glu His  Gly Pro Phe 
    1025                 1030                 1035             


Cys Gly  Lys Thr Leu Pro His  Arg Ile Glu Thr Lys  Ser Asn Thr 
    1040                 1045                 1050             


Val Thr  Ile Thr Phe Val Thr  Asp Glu Ser Gly Asp  His Thr Gly 
    1055                 1060                 1065             


Trp Lys  Ile His Tyr Thr Ser  Thr Ala Gln Pro Cys  Pro Tyr Pro 
    1070                 1075                 1080             


Met Ala  Pro Pro Asn Gly His  Val Ser Pro Val Gln  Ala Lys Tyr 
    1085                 1090                 1095             


Ile Leu  Lys Asp Ser Phe Ser  Ile Phe Cys Glu Thr  Gly Tyr Glu 
    1100                 1105                 1110             


Leu Leu  Gln Gly His Leu Pro  Leu Lys Ser Phe Thr  Ala Val Cys 
    1115                 1120                 1125             


Gln Lys  Asp Gly Ser Trp Asp  Arg Pro Met Pro Ala  Cys Ser Ile 
    1130                 1135                 1140             


Val Asp  Cys Gly Pro Pro Asp  Asp Leu Pro Ser Gly  Arg Val Glu 
    1145                 1150                 1155             


Tyr Ile  Thr Gly Pro Gly Val  Thr Thr Tyr Lys Ala  Val Ile Gln 
    1160                 1165                 1170             


Tyr Ser  Cys Glu Glu Thr Phe  Tyr Thr Met Lys Val  Asn Asp Gly 
    1175                 1180                 1185             


Lys Tyr  Val Cys Glu Ala Asp  Gly Phe Trp Thr Ser  Ser Lys Gly 
    1190                 1195                 1200             


Glu Lys  Ser Leu Pro Val Cys  Glu Pro Val Cys Gly  Leu Ser Ala 
    1205                 1210                 1215             


Arg Thr  Thr Gly Gly Arg Ile  Tyr Gly Gly Gln Lys  Ala Lys Pro 
    1220                 1225                 1230             


Gly Asp  Phe Pro Trp Gln Val  Leu Ile Leu Gly Gly  Thr Thr Ala 
    1235                 1240                 1245             


Ala Gly  Ala Leu Leu Tyr Asp  Asn Trp Val Leu Thr  Ala Ala His 
    1250                 1255                 1260             


Ala Val  Tyr Glu Gln Lys His  Asp Ala Ser Ala Leu  Asp Ile Arg 
    1265                 1270                 1275             


Met Gly  Thr Leu Lys Arg Leu  Ser Pro His Tyr Thr  Gln Ala Trp 
    1280                 1285                 1290             


Ser Glu  Ala Val Phe Ile His  Glu Gly Tyr Thr His  Asp Ala Gly 
    1295                 1300                 1305             


Phe Asp  Asn Asp Ile Ala Leu  Ile Lys Leu Asn Asn  Lys Val Val 
    1310                 1315                 1320             


Ile Asn  Ser Asn Ile Thr Pro  Ile Cys Leu Pro Arg  Lys Glu Ala 
    1325                 1330                 1335             


Glu Ser  Phe Met Arg Thr Asp  Asp Ile Gly Thr Ala  Ser Gly Trp 
    1340                 1345                 1350             


Gly Leu  Thr Gln Arg Gly Phe  Leu Ala Arg Asn Leu  Met Tyr Val 
    1355                 1360                 1365             


Asp Ile  Pro Ile Val Asp His  Gln Lys Cys Thr Ala  Ala Tyr Glu 
    1370                 1375                 1380             


Lys Pro  Pro Tyr Pro Arg Gly  Ser Val Thr Ala Asn  Met Leu Cys 
    1385                 1390                 1395             


Ala Gly  Leu Glu Ser Gly Gly  Lys Asp Ser Cys Arg  Gly Asp Ser 
    1400                 1405                 1410             


Gly Gly  Ala Leu Val Phe Leu  Asp Ser Glu Thr Glu  Arg Trp Phe 
    1415                 1420                 1425             


Val Gly  Gly Ile Val Ser Trp  Gly Ser Met Asn Cys  Gly Glu Ala 
    1430                 1435                 1440             


Gly Gln  Tyr Gly Val Tyr Thr  Lys Val Ile Asn Tyr  Ile Pro Trp 
    1445                 1450                 1455             


Ile Glu  Asn Ile Ile Ser Asp  Phe 
    1460                 1465     


<210>  5
<211>  2164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary recombinant protein of the invention with the following
       domain configuration MASP2 - L -  MBL-2 - L - MBL-2 - L -  MBL-2 
       - L - MASP2

<400>  5

Met Arg Leu Leu Thr Leu Leu Gly Leu Leu Cys Gly Ser Val Ala Thr 
1               5                   10                  15      


Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala Ser 
            20                  25                  30          


Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp Thr 
        35                  40                  45              


Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60                  


Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu Ser 
65                  70                  75                  80  


Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95      


Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser Ser 
            100                 105                 110         


Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125             


Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln Val 
    130                 135                 140                 


Ala Pro Gly Glu Ala Pro Thr Cys Asp His His Cys His Asn His Leu 
145                 150                 155                 160 


Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg Asn 
                165                 170                 175     


Lys Arg Thr Cys Ser Ala Leu Cys Ser Gly Gln Val Phe Thr Gln Arg 
            180                 185                 190         


Ser Gly Glu Leu Ser Ser Pro Glu Tyr Pro Arg Pro Tyr Pro Lys Leu 
        195                 200                 205             


Ser Ser Cys Thr Tyr Ser Ile Ser Leu Glu Glu Gly Phe Ser Val Ile 
    210                 215                 220                 


Leu Asp Phe Val Glu Ser Phe Asp Val Glu Thr His Pro Glu Thr Leu 
225                 230                 235                 240 


Cys Pro Tyr Asp Phe Leu Lys Ile Gln Thr Asp Arg Glu Glu His Gly 
                245                 250                 255     


Pro Phe Cys Gly Lys Thr Leu Pro His Arg Ile Glu Thr Lys Ser Asn 
            260                 265                 270         


Thr Val Thr Ile Thr Phe Val Thr Asp Glu Ser Gly Asp His Thr Gly 
        275                 280                 285             


Trp Lys Ile His Tyr Thr Ser Thr Ala Gln Pro Cys Pro Tyr Pro Met 
    290                 295                 300                 


Ala Pro Pro Asn Gly His Val Ser Pro Val Gln Ala Lys Tyr Ile Leu 
305                 310                 315                 320 


Lys Asp Ser Phe Ser Ile Phe Cys Glu Thr Gly Tyr Glu Leu Leu Gln 
                325                 330                 335     


Gly His Leu Pro Leu Lys Ser Phe Thr Ala Val Cys Gln Lys Asp Gly 
            340                 345                 350         


Ser Trp Asp Arg Pro Met Pro Ala Cys Ser Ile Val Asp Cys Gly Pro 
        355                 360                 365             


Pro Asp Asp Leu Pro Ser Gly Arg Val Glu Tyr Ile Thr Gly Pro Gly 
    370                 375                 380                 


Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr Ser Cys Glu Glu Thr Phe 
385                 390                 395                 400 


Tyr Thr Met Lys Val Asn Asp Gly Lys Tyr Val Cys Glu Ala Asp Gly 
                405                 410                 415     


Phe Trp Thr Ser Ser Lys Gly Glu Lys Ser Leu Pro Val Cys Glu Pro 
            420                 425                 430         


Val Cys Gly Leu Ser Ala Arg Thr Thr Gly Gly Arg Ile Tyr Gly Gly 
        435                 440                 445             


Gln Lys Ala Lys Pro Gly Asp Phe Pro Trp Gln Val Leu Ile Leu Gly 
    450                 455                 460                 


Gly Thr Thr Ala Ala Gly Ala Leu Leu Tyr Asp Asn Trp Val Leu Thr 
465                 470                 475                 480 


Ala Ala His Ala Val Tyr Glu Gln Lys His Asp Ala Ser Ala Leu Asp 
                485                 490                 495     


Ile Arg Met Gly Thr Leu Lys Arg Leu Ser Pro His Tyr Thr Gln Ala 
            500                 505                 510         


Trp Ser Glu Ala Val Phe Ile His Glu Gly Tyr Thr His Asp Ala Gly 
        515                 520                 525             


Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu Asn Asn Lys Val Val Ile 
    530                 535                 540                 


Asn Ser Asn Ile Thr Pro Ile Cys Leu Pro Arg Lys Glu Ala Glu Ser 
545                 550                 555                 560 


Phe Met Arg Thr Asp Asp Ile Gly Thr Ala Ser Gly Trp Gly Leu Thr 
                565                 570                 575     


Gln Arg Gly Phe Leu Ala Arg Asn Leu Met Tyr Val Asp Ile Pro Ile 
            580                 585                 590         


Val Asp His Gln Lys Cys Thr Ala Ala Tyr Glu Lys Pro Pro Tyr Pro 
        595                 600                 605             


Arg Gly Ser Val Thr Ala Asn Met Leu Cys Ala Gly Leu Glu Ser Gly 
    610                 615                 620                 


Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly Ala Leu Val Phe Leu 
625                 630                 635                 640 


Asp Ser Glu Thr Glu Arg Trp Phe Val Gly Gly Ile Val Ser Trp Gly 
                645                 650                 655     


Ser Met Asn Cys Gly Glu Ala Gly Gln Tyr Gly Val Tyr Thr Lys Val 
            660                 665                 670         


Ile Asn Tyr Ile Pro Trp Ile Glu Asn Ile Ile Ser Asp Phe Gly Gly 
        675                 680                 685             


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Met Ser Leu Phe Pro Ser 
    690                 695                 700                 


Leu Pro Leu Leu Leu Leu Ser Met Val Ala Ala Ser Tyr Ser Glu Thr 
705                 710                 715                 720 


Val Thr Cys Glu Asp Ala Gln Lys Thr Cys Pro Ala Val Ile Ala Cys 
                725                 730                 735     


Ser Ser Pro Gly Ile Asn Gly Phe Pro Gly Lys Asp Gly Arg Asp Gly 
            740                 745                 750         


Thr Lys Gly Glu Lys Gly Glu Pro Gly Gln Gly Leu Arg Gly Leu Gln 
        755                 760                 765             


Gly Pro Pro Gly Lys Leu Gly Pro Pro Gly Asn Pro Gly Pro Ser Gly 
    770                 775                 780                 


Ser Pro Gly Pro Lys Gly Gln Lys Gly Asp Pro Gly Lys Ser Pro Asp 
785                 790                 795                 800 


Gly Asp Ser Ser Leu Ala Ala Ser Glu Arg Lys Ala Leu Gln Thr Glu 
                805                 810                 815     


Met Ala Arg Ile Lys Lys Trp Leu Thr Phe Ser Leu Gly Lys Gln Val 
            820                 825                 830         


Gly Asn Lys Phe Phe Leu Thr Asn Gly Glu Ile Met Thr Phe Glu Lys 
        835                 840                 845             


Val Lys Ala Leu Cys Val Lys Phe Gln Ala Ser Val Ala Thr Pro Arg 
    850                 855                 860                 


Asn Ala Ala Glu Asn Gly Ala Ile Gln Asn Leu Ile Lys Glu Glu Ala 
865                 870                 875                 880 


Phe Leu Gly Ile Thr Asp Glu Lys Thr Glu Gly Gln Phe Val Asp Leu 
                885                 890                 895     


Thr Gly Asn Arg Leu Thr Tyr Thr Asn Trp Asn Glu Gly Glu Pro Asn 
            900                 905                 910         


Asn Ala Gly Ser Asp Glu Asp Cys Val Leu Leu Leu Lys Asn Gly Gln 
        915                 920                 925             


Trp Asn Asp Val Pro Cys Ser Thr Ser His Leu Ala Val Cys Glu Phe 
    930                 935                 940                 


Pro Ile Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Met Ser 
945                 950                 955                 960 


Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu Ser Met Val Ala Ala Ser 
                965                 970                 975     


Tyr Ser Glu Thr Val Thr Cys Glu Asp Ala Gln Lys Thr Cys Pro Ala 
            980                 985                 990         


Val Ile Ala Cys Ser Ser Pro Gly  Ile Asn Gly Phe Pro  Gly Lys Asp 
        995                 1000                 1005             


Gly Arg  Asp Gly Thr Lys Gly  Glu Lys Gly Glu Pro  Gly Gln Gly 
    1010                 1015                 1020             


Leu Arg  Gly Leu Gln Gly Pro  Pro Gly Lys Leu Gly  Pro Pro Gly 
    1025                 1030                 1035             


Asn Pro  Gly Pro Ser Gly Ser  Pro Gly Pro Lys Gly  Gln Lys Gly 
    1040                 1045                 1050             


Asp Pro  Gly Lys Ser Pro Asp  Gly Asp Ser Ser Leu  Ala Ala Ser 
    1055                 1060                 1065             


Glu Arg  Lys Ala Leu Gln Thr  Glu Met Ala Arg Ile  Lys Lys Trp 
    1070                 1075                 1080             


Leu Thr  Phe Ser Leu Gly Lys  Gln Val Gly Asn Lys  Phe Phe Leu 
    1085                 1090                 1095             


Thr Asn  Gly Glu Ile Met Thr  Phe Glu Lys Val Lys  Ala Leu Cys 
    1100                 1105                 1110             


Val Lys  Phe Gln Ala Ser Val  Ala Thr Pro Arg Asn  Ala Ala Glu 
    1115                 1120                 1125             


Asn Gly  Ala Ile Gln Asn Leu  Ile Lys Glu Glu Ala  Phe Leu Gly 
    1130                 1135                 1140             


Ile Thr  Asp Glu Lys Thr Glu  Gly Gln Phe Val Asp  Leu Thr Gly 
    1145                 1150                 1155             


Asn Arg  Leu Thr Tyr Thr Asn  Trp Asn Glu Gly Glu  Pro Asn Asn 
    1160                 1165                 1170             


Ala Gly  Ser Asp Glu Asp Cys  Val Leu Leu Leu Lys  Asn Gly Gln 
    1175                 1180                 1185             


Trp Asn  Asp Val Pro Cys Ser  Thr Ser His Leu Ala  Val Cys Glu 
    1190                 1195                 1200             


Phe Pro  Ile Gly Gly Gly Gly  Gly Gly Gly Gly Gly  Gly Gly Gly 
    1205                 1210                 1215             


Met Ser  Leu Phe Pro Ser Leu  Pro Leu Leu Leu Leu  Ser Met Val 
    1220                 1225                 1230             


Ala Ala  Ser Tyr Ser Glu Thr  Val Thr Cys Glu Asp  Ala Gln Lys 
    1235                 1240                 1245             


Thr Cys  Pro Ala Val Ile Ala  Cys Ser Ser Pro Gly  Ile Asn Gly 
    1250                 1255                 1260             


Phe Pro  Gly Lys Asp Gly Arg  Asp Gly Thr Lys Gly  Glu Lys Gly 
    1265                 1270                 1275             


Glu Pro  Gly Gln Gly Leu Arg  Gly Leu Gln Gly Pro  Pro Gly Lys 
    1280                 1285                 1290             


Leu Gly  Pro Pro Gly Asn Pro  Gly Pro Ser Gly Ser  Pro Gly Pro 
    1295                 1300                 1305             


Lys Gly  Gln Lys Gly Asp Pro  Gly Lys Ser Pro Asp  Gly Asp Ser 
    1310                 1315                 1320             


Ser Leu  Ala Ala Ser Glu Arg  Lys Ala Leu Gln Thr  Glu Met Ala 
    1325                 1330                 1335             


Arg Ile  Lys Lys Trp Leu Thr  Phe Ser Leu Gly Lys  Gln Val Gly 
    1340                 1345                 1350             


Asn Lys  Phe Phe Leu Thr Asn  Gly Glu Ile Met Thr  Phe Glu Lys 
    1355                 1360                 1365             


Val Lys  Ala Leu Cys Val Lys  Phe Gln Ala Ser Val  Ala Thr Pro 
    1370                 1375                 1380             


Arg Asn  Ala Ala Glu Asn Gly  Ala Ile Gln Asn Leu  Ile Lys Glu 
    1385                 1390                 1395             


Glu Ala  Phe Leu Gly Ile Thr  Asp Glu Lys Thr Glu  Gly Gln Phe 
    1400                 1405                 1410             


Val Asp  Leu Thr Gly Asn Arg  Leu Thr Tyr Thr Asn  Trp Asn Glu 
    1415                 1420                 1425             


Gly Glu  Pro Asn Asn Ala Gly  Ser Asp Glu Asp Cys  Val Leu Leu 
    1430                 1435                 1440             


Leu Lys  Asn Gly Gln Trp Asn  Asp Val Pro Cys Ser  Thr Ser His 
    1445                 1450                 1455             


Leu Ala  Val Cys Glu Phe Pro  Ile Gly Gly Gly Gly  Gly Gly Gly 
    1460                 1465                 1470             


Gly Gly  Gly Gly Gly Met Arg  Leu Leu Thr Leu Leu  Gly Leu Leu 
    1475                 1480                 1485             


Cys Gly  Ser Val Ala Thr Pro  Leu Gly Pro Lys Trp  Pro Glu Pro 
    1490                 1495                 1500             


Val Phe  Gly Arg Leu Ala Ser  Pro Gly Phe Pro Gly  Glu Tyr Ala 
    1505                 1510                 1515             


Asn Asp  Gln Glu Arg Arg Trp  Thr Leu Thr Ala Pro  Pro Gly Tyr 
    1520                 1525                 1530             


Arg Leu  Arg Leu Tyr Phe Thr  His Phe Asp Leu Glu  Leu Ser His 
    1535                 1540                 1545             


Leu Cys  Glu Tyr Asp Phe Val  Lys Leu Ser Ser Gly  Ala Lys Val 
    1550                 1555                 1560             


Leu Ala  Thr Leu Cys Gly Gln  Glu Ser Thr Asp Thr  Glu Arg Ala 
    1565                 1570                 1575             


Pro Gly  Lys Asp Thr Phe Tyr  Ser Leu Gly Ser Ser  Leu Asp Ile 
    1580                 1585                 1590             


Thr Phe  Arg Ser Asp Tyr Ser  Asn Glu Lys Pro Phe  Thr Gly Phe 
    1595                 1600                 1605             


Glu Ala  Phe Tyr Ala Ala Glu  Asp Ile Asp Glu Cys  Gln Val Ala 
    1610                 1615                 1620             


Pro Gly  Glu Ala Pro Thr Cys  Asp His His Cys His  Asn His Leu 
    1625                 1630                 1635             


Gly Gly  Phe Tyr Cys Ser Cys  Arg Ala Gly Tyr Val  Leu His Arg 
    1640                 1645                 1650             


Asn Lys  Arg Thr Cys Ser Ala  Leu Cys Ser Gly Gln  Val Phe Thr 
    1655                 1660                 1665             


Gln Arg  Ser Gly Glu Leu Ser  Ser Pro Glu Tyr Pro  Arg Pro Tyr 
    1670                 1675                 1680             


Pro Lys  Leu Ser Ser Cys Thr  Tyr Ser Ile Ser Leu  Glu Glu Gly 
    1685                 1690                 1695             


Phe Ser  Val Ile Leu Asp Phe  Val Glu Ser Phe Asp  Val Glu Thr 
    1700                 1705                 1710             


His Pro  Glu Thr Leu Cys Pro  Tyr Asp Phe Leu Lys  Ile Gln Thr 
    1715                 1720                 1725             


Asp Arg  Glu Glu His Gly Pro  Phe Cys Gly Lys Thr  Leu Pro His 
    1730                 1735                 1740             


Arg Ile  Glu Thr Lys Ser Asn  Thr Val Thr Ile Thr  Phe Val Thr 
    1745                 1750                 1755             


Asp Glu  Ser Gly Asp His Thr  Gly Trp Lys Ile His  Tyr Thr Ser 
    1760                 1765                 1770             


Thr Ala  Gln Pro Cys Pro Tyr  Pro Met Ala Pro Pro  Asn Gly His 
    1775                 1780                 1785             


Val Ser  Pro Val Gln Ala Lys  Tyr Ile Leu Lys Asp  Ser Phe Ser 
    1790                 1795                 1800             


Ile Phe  Cys Glu Thr Gly Tyr  Glu Leu Leu Gln Gly  His Leu Pro 
    1805                 1810                 1815             


Leu Lys  Ser Phe Thr Ala Val  Cys Gln Lys Asp Gly  Ser Trp Asp 
    1820                 1825                 1830             


Arg Pro  Met Pro Ala Cys Ser  Ile Val Asp Cys Gly  Pro Pro Asp 
    1835                 1840                 1845             


Asp Leu  Pro Ser Gly Arg Val  Glu Tyr Ile Thr Gly  Pro Gly Val 
    1850                 1855                 1860             


Thr Thr  Tyr Lys Ala Val Ile  Gln Tyr Ser Cys Glu  Glu Thr Phe 
    1865                 1870                 1875             


Tyr Thr  Met Lys Val Asn Asp  Gly Lys Tyr Val Cys  Glu Ala Asp 
    1880                 1885                 1890             


Gly Phe  Trp Thr Ser Ser Lys  Gly Glu Lys Ser Leu  Pro Val Cys 
    1895                 1900                 1905             


Glu Pro  Val Cys Gly Leu Ser  Ala Arg Thr Thr Gly  Gly Arg Ile 
    1910                 1915                 1920             


Tyr Gly  Gly Gln Lys Ala Lys  Pro Gly Asp Phe Pro  Trp Gln Val 
    1925                 1930                 1935             


Leu Ile  Leu Gly Gly Thr Thr  Ala Ala Gly Ala Leu  Leu Tyr Asp 
    1940                 1945                 1950             


Asn Trp  Val Leu Thr Ala Ala  His Ala Val Tyr Glu  Gln Lys His 
    1955                 1960                 1965             


Asp Ala  Ser Ala Leu Asp Ile  Arg Met Gly Thr Leu  Lys Arg Leu 
    1970                 1975                 1980             


Ser Pro  His Tyr Thr Gln Ala  Trp Ser Glu Ala Val  Phe Ile His 
    1985                 1990                 1995             


Glu Gly  Tyr Thr His Asp Ala  Gly Phe Asp Asn Asp  Ile Ala Leu 
    2000                 2005                 2010             


Ile Lys  Leu Asn Asn Lys Val  Val Ile Asn Ser Asn  Ile Thr Pro 
    2015                 2020                 2025             


Ile Cys  Leu Pro Arg Lys Glu  Ala Glu Ser Phe Met  Arg Thr Asp 
    2030                 2035                 2040             


Asp Ile  Gly Thr Ala Ser Gly  Trp Gly Leu Thr Gln  Arg Gly Phe 
    2045                 2050                 2055             


Leu Ala  Arg Asn Leu Met Tyr  Val Asp Ile Pro Ile  Val Asp His 
    2060                 2065                 2070             


Gln Lys  Cys Thr Ala Ala Tyr  Glu Lys Pro Pro Tyr  Pro Arg Gly 
    2075                 2080                 2085             


Ser Val  Thr Ala Asn Met Leu  Cys Ala Gly Leu Glu  Ser Gly Gly 
    2090                 2095                 2100             


Lys Asp  Ser Cys Arg Gly Asp  Ser Gly Gly Ala Leu  Val Phe Leu 
    2105                 2110                 2115             


Asp Ser  Glu Thr Glu Arg Trp  Phe Val Gly Gly Ile  Val Ser Trp 
    2120                 2125                 2130             


Gly Ser  Met Asn Cys Gly Glu  Ala Gly Gln Tyr Gly  Val Tyr Thr 
    2135                 2140                 2145             


Lys Val  Ile Asn Tyr Ile Pro  Trp Ile Glu Asn Ile  Ile Ser Asp 
    2150                 2155                 2160             


Phe 
    


<210>  6
<211>  992
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary recombinant protein of the invention with the following
       domain configuration MBL-2 - MBL-2 - MBL2 - MBL-2

<400>  6

Met Ser Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu Ser Met Val Ala 
1               5                   10                  15      


Ala Ser Tyr Ser Glu Thr Val Thr Cys Glu Asp Ala Gln Lys Thr Cys 
            20                  25                  30          


Pro Ala Val Ile Ala Cys Ser Ser Pro Gly Ile Asn Gly Phe Pro Gly 
        35                  40                  45              


Lys Asp Gly Arg Asp Gly Thr Lys Gly Glu Lys Gly Glu Pro Gly Gln 
    50                  55                  60                  


Gly Leu Arg Gly Leu Gln Gly Pro Pro Gly Lys Leu Gly Pro Pro Gly 
65                  70                  75                  80  


Asn Pro Gly Pro Ser Gly Ser Pro Gly Pro Lys Gly Gln Lys Gly Asp 
                85                  90                  95      


Pro Gly Lys Ser Pro Asp Gly Asp Ser Ser Leu Ala Ala Ser Glu Arg 
            100                 105                 110         


Lys Ala Leu Gln Thr Glu Met Ala Arg Ile Lys Lys Trp Leu Thr Phe 
        115                 120                 125             


Ser Leu Gly Lys Gln Val Gly Asn Lys Phe Phe Leu Thr Asn Gly Glu 
    130                 135                 140                 


Ile Met Thr Phe Glu Lys Val Lys Ala Leu Cys Val Lys Phe Gln Ala 
145                 150                 155                 160 


Ser Val Ala Thr Pro Arg Asn Ala Ala Glu Asn Gly Ala Ile Gln Asn 
                165                 170                 175     


Leu Ile Lys Glu Glu Ala Phe Leu Gly Ile Thr Asp Glu Lys Thr Glu 
            180                 185                 190         


Gly Gln Phe Val Asp Leu Thr Gly Asn Arg Leu Thr Tyr Thr Asn Trp 
        195                 200                 205             


Asn Glu Gly Glu Pro Asn Asn Ala Gly Ser Asp Glu Asp Cys Val Leu 
    210                 215                 220                 


Leu Leu Lys Asn Gly Gln Trp Asn Asp Val Pro Cys Ser Thr Ser His 
225                 230                 235                 240 


Leu Ala Val Cys Glu Phe Pro Ile Met Ser Leu Phe Pro Ser Leu Pro 
                245                 250                 255     


Leu Leu Leu Leu Ser Met Val Ala Ala Ser Tyr Ser Glu Thr Val Thr 
            260                 265                 270         


Cys Glu Asp Ala Gln Lys Thr Cys Pro Ala Val Ile Ala Cys Ser Ser 
        275                 280                 285             


Pro Gly Ile Asn Gly Phe Pro Gly Lys Asp Gly Arg Asp Gly Thr Lys 
    290                 295                 300                 


Gly Glu Lys Gly Glu Pro Gly Gln Gly Leu Arg Gly Leu Gln Gly Pro 
305                 310                 315                 320 


Pro Gly Lys Leu Gly Pro Pro Gly Asn Pro Gly Pro Ser Gly Ser Pro 
                325                 330                 335     


Gly Pro Lys Gly Gln Lys Gly Asp Pro Gly Lys Ser Pro Asp Gly Asp 
            340                 345                 350         


Ser Ser Leu Ala Ala Ser Glu Arg Lys Ala Leu Gln Thr Glu Met Ala 
        355                 360                 365             


Arg Ile Lys Lys Trp Leu Thr Phe Ser Leu Gly Lys Gln Val Gly Asn 
    370                 375                 380                 


Lys Phe Phe Leu Thr Asn Gly Glu Ile Met Thr Phe Glu Lys Val Lys 
385                 390                 395                 400 


Ala Leu Cys Val Lys Phe Gln Ala Ser Val Ala Thr Pro Arg Asn Ala 
                405                 410                 415     


Ala Glu Asn Gly Ala Ile Gln Asn Leu Ile Lys Glu Glu Ala Phe Leu 
            420                 425                 430         


Gly Ile Thr Asp Glu Lys Thr Glu Gly Gln Phe Val Asp Leu Thr Gly 
        435                 440                 445             


Asn Arg Leu Thr Tyr Thr Asn Trp Asn Glu Gly Glu Pro Asn Asn Ala 
    450                 455                 460                 


Gly Ser Asp Glu Asp Cys Val Leu Leu Leu Lys Asn Gly Gln Trp Asn 
465                 470                 475                 480 


Asp Val Pro Cys Ser Thr Ser His Leu Ala Val Cys Glu Phe Pro Ile 
                485                 490                 495     


Met Ser Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu Ser Met Val Ala 
            500                 505                 510         


Ala Ser Tyr Ser Glu Thr Val Thr Cys Glu Asp Ala Gln Lys Thr Cys 
        515                 520                 525             


Pro Ala Val Ile Ala Cys Ser Ser Pro Gly Ile Asn Gly Phe Pro Gly 
    530                 535                 540                 


Lys Asp Gly Arg Asp Gly Thr Lys Gly Glu Lys Gly Glu Pro Gly Gln 
545                 550                 555                 560 


Gly Leu Arg Gly Leu Gln Gly Pro Pro Gly Lys Leu Gly Pro Pro Gly 
                565                 570                 575     


Asn Pro Gly Pro Ser Gly Ser Pro Gly Pro Lys Gly Gln Lys Gly Asp 
            580                 585                 590         


Pro Gly Lys Ser Pro Asp Gly Asp Ser Ser Leu Ala Ala Ser Glu Arg 
        595                 600                 605             


Lys Ala Leu Gln Thr Glu Met Ala Arg Ile Lys Lys Trp Leu Thr Phe 
    610                 615                 620                 


Ser Leu Gly Lys Gln Val Gly Asn Lys Phe Phe Leu Thr Asn Gly Glu 
625                 630                 635                 640 


Ile Met Thr Phe Glu Lys Val Lys Ala Leu Cys Val Lys Phe Gln Ala 
                645                 650                 655     


Ser Val Ala Thr Pro Arg Asn Ala Ala Glu Asn Gly Ala Ile Gln Asn 
            660                 665                 670         


Leu Ile Lys Glu Glu Ala Phe Leu Gly Ile Thr Asp Glu Lys Thr Glu 
        675                 680                 685             


Gly Gln Phe Val Asp Leu Thr Gly Asn Arg Leu Thr Tyr Thr Asn Trp 
    690                 695                 700                 


Asn Glu Gly Glu Pro Asn Asn Ala Gly Ser Asp Glu Asp Cys Val Leu 
705                 710                 715                 720 


Leu Leu Lys Asn Gly Gln Trp Asn Asp Val Pro Cys Ser Thr Ser His 
                725                 730                 735     


Leu Ala Val Cys Glu Phe Pro Ile Met Ser Leu Phe Pro Ser Leu Pro 
            740                 745                 750         


Leu Leu Leu Leu Ser Met Val Ala Ala Ser Tyr Ser Glu Thr Val Thr 
        755                 760                 765             


Cys Glu Asp Ala Gln Lys Thr Cys Pro Ala Val Ile Ala Cys Ser Ser 
    770                 775                 780                 


Pro Gly Ile Asn Gly Phe Pro Gly Lys Asp Gly Arg Asp Gly Thr Lys 
785                 790                 795                 800 


Gly Glu Lys Gly Glu Pro Gly Gln Gly Leu Arg Gly Leu Gln Gly Pro 
                805                 810                 815     


Pro Gly Lys Leu Gly Pro Pro Gly Asn Pro Gly Pro Ser Gly Ser Pro 
            820                 825                 830         


Gly Pro Lys Gly Gln Lys Gly Asp Pro Gly Lys Ser Pro Asp Gly Asp 
        835                 840                 845             


Ser Ser Leu Ala Ala Ser Glu Arg Lys Ala Leu Gln Thr Glu Met Ala 
    850                 855                 860                 


Arg Ile Lys Lys Trp Leu Thr Phe Ser Leu Gly Lys Gln Val Gly Asn 
865                 870                 875                 880 


Lys Phe Phe Leu Thr Asn Gly Glu Ile Met Thr Phe Glu Lys Val Lys 
                885                 890                 895     


Ala Leu Cys Val Lys Phe Gln Ala Ser Val Ala Thr Pro Arg Asn Ala 
            900                 905                 910         


Ala Glu Asn Gly Ala Ile Gln Asn Leu Ile Lys Glu Glu Ala Phe Leu 
        915                 920                 925             


Gly Ile Thr Asp Glu Lys Thr Glu Gly Gln Phe Val Asp Leu Thr Gly 
    930                 935                 940                 


Asn Arg Leu Thr Tyr Thr Asn Trp Asn Glu Gly Glu Pro Asn Asn Ala 
945                 950                 955                 960 


Gly Ser Asp Glu Asp Cys Val Leu Leu Leu Lys Asn Gly Gln Trp Asn 
                965                 970                 975     


Asp Val Pro Cys Ser Thr Ser His Leu Ala Val Cys Glu Phe Pro Ile 
            980                 985                 990         


<210>  7
<211>  744
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary recombinant protein of the invention with the following
       domain configuration: MBL-2 - MBL-2 - MBL-2

<400>  7

Met Ser Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu Ser Met Val Ala 
1               5                   10                  15      


Ala Ser Tyr Ser Glu Thr Val Thr Cys Glu Asp Ala Gln Lys Thr Cys 
            20                  25                  30          


Pro Ala Val Ile Ala Cys Ser Ser Pro Gly Ile Asn Gly Phe Pro Gly 
        35                  40                  45              


Lys Asp Gly Arg Asp Gly Thr Lys Gly Glu Lys Gly Glu Pro Gly Gln 
    50                  55                  60                  


Gly Leu Arg Gly Leu Gln Gly Pro Pro Gly Lys Leu Gly Pro Pro Gly 
65                  70                  75                  80  


Asn Pro Gly Pro Ser Gly Ser Pro Gly Pro Lys Gly Gln Lys Gly Asp 
                85                  90                  95      


Pro Gly Lys Ser Pro Asp Gly Asp Ser Ser Leu Ala Ala Ser Glu Arg 
            100                 105                 110         


Lys Ala Leu Gln Thr Glu Met Ala Arg Ile Lys Lys Trp Leu Thr Phe 
        115                 120                 125             


Ser Leu Gly Lys Gln Val Gly Asn Lys Phe Phe Leu Thr Asn Gly Glu 
    130                 135                 140                 


Ile Met Thr Phe Glu Lys Val Lys Ala Leu Cys Val Lys Phe Gln Ala 
145                 150                 155                 160 


Ser Val Ala Thr Pro Arg Asn Ala Ala Glu Asn Gly Ala Ile Gln Asn 
                165                 170                 175     


Leu Ile Lys Glu Glu Ala Phe Leu Gly Ile Thr Asp Glu Lys Thr Glu 
            180                 185                 190         


Gly Gln Phe Val Asp Leu Thr Gly Asn Arg Leu Thr Tyr Thr Asn Trp 
        195                 200                 205             


Asn Glu Gly Glu Pro Asn Asn Ala Gly Ser Asp Glu Asp Cys Val Leu 
    210                 215                 220                 


Leu Leu Lys Asn Gly Gln Trp Asn Asp Val Pro Cys Ser Thr Ser His 
225                 230                 235                 240 


Leu Ala Val Cys Glu Phe Pro Ile Met Ser Leu Phe Pro Ser Leu Pro 
                245                 250                 255     


Leu Leu Leu Leu Ser Met Val Ala Ala Ser Tyr Ser Glu Thr Val Thr 
            260                 265                 270         


Cys Glu Asp Ala Gln Lys Thr Cys Pro Ala Val Ile Ala Cys Ser Ser 
        275                 280                 285             


Pro Gly Ile Asn Gly Phe Pro Gly Lys Asp Gly Arg Asp Gly Thr Lys 
    290                 295                 300                 


Gly Glu Lys Gly Glu Pro Gly Gln Gly Leu Arg Gly Leu Gln Gly Pro 
305                 310                 315                 320 


Pro Gly Lys Leu Gly Pro Pro Gly Asn Pro Gly Pro Ser Gly Ser Pro 
                325                 330                 335     


Gly Pro Lys Gly Gln Lys Gly Asp Pro Gly Lys Ser Pro Asp Gly Asp 
            340                 345                 350         


Ser Ser Leu Ala Ala Ser Glu Arg Lys Ala Leu Gln Thr Glu Met Ala 
        355                 360                 365             


Arg Ile Lys Lys Trp Leu Thr Phe Ser Leu Gly Lys Gln Val Gly Asn 
    370                 375                 380                 


Lys Phe Phe Leu Thr Asn Gly Glu Ile Met Thr Phe Glu Lys Val Lys 
385                 390                 395                 400 


Ala Leu Cys Val Lys Phe Gln Ala Ser Val Ala Thr Pro Arg Asn Ala 
                405                 410                 415     


Ala Glu Asn Gly Ala Ile Gln Asn Leu Ile Lys Glu Glu Ala Phe Leu 
            420                 425                 430         


Gly Ile Thr Asp Glu Lys Thr Glu Gly Gln Phe Val Asp Leu Thr Gly 
        435                 440                 445             


Asn Arg Leu Thr Tyr Thr Asn Trp Asn Glu Gly Glu Pro Asn Asn Ala 
    450                 455                 460                 


Gly Ser Asp Glu Asp Cys Val Leu Leu Leu Lys Asn Gly Gln Trp Asn 
465                 470                 475                 480 


Asp Val Pro Cys Ser Thr Ser His Leu Ala Val Cys Glu Phe Pro Ile 
                485                 490                 495     


Met Ser Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu Ser Met Val Ala 
            500                 505                 510         


Ala Ser Tyr Ser Glu Thr Val Thr Cys Glu Asp Ala Gln Lys Thr Cys 
        515                 520                 525             


Pro Ala Val Ile Ala Cys Ser Ser Pro Gly Ile Asn Gly Phe Pro Gly 
    530                 535                 540                 


Lys Asp Gly Arg Asp Gly Thr Lys Gly Glu Lys Gly Glu Pro Gly Gln 
545                 550                 555                 560 


Gly Leu Arg Gly Leu Gln Gly Pro Pro Gly Lys Leu Gly Pro Pro Gly 
                565                 570                 575     


Asn Pro Gly Pro Ser Gly Ser Pro Gly Pro Lys Gly Gln Lys Gly Asp 
            580                 585                 590         


Pro Gly Lys Ser Pro Asp Gly Asp Ser Ser Leu Ala Ala Ser Glu Arg 
        595                 600                 605             


Lys Ala Leu Gln Thr Glu Met Ala Arg Ile Lys Lys Trp Leu Thr Phe 
    610                 615                 620                 


Ser Leu Gly Lys Gln Val Gly Asn Lys Phe Phe Leu Thr Asn Gly Glu 
625                 630                 635                 640 


Ile Met Thr Phe Glu Lys Val Lys Ala Leu Cys Val Lys Phe Gln Ala 
                645                 650                 655     


Ser Val Ala Thr Pro Arg Asn Ala Ala Glu Asn Gly Ala Ile Gln Asn 
            660                 665                 670         


Leu Ile Lys Glu Glu Ala Phe Leu Gly Ile Thr Asp Glu Lys Thr Glu 
        675                 680                 685             


Gly Gln Phe Val Asp Leu Thr Gly Asn Arg Leu Thr Tyr Thr Asn Trp 
    690                 695                 700                 


Asn Glu Gly Glu Pro Asn Asn Ala Gly Ser Asp Glu Asp Cys Val Leu 
705                 710                 715                 720 


Leu Leu Lys Asn Gly Gln Trp Asn Asp Val Pro Cys Ser Thr Ser His 
                725                 730                 735     


Leu Ala Val Cys Glu Phe Pro Ile 
            740                 


<210>  8
<211>  1028
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary recombinant protein of the invention with the following
       domain configuration: MBL-2 - L - MBL-2 - L - MBL-2 - L - MBL-2

<400>  8

Met Ser Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu Ser Met Val Ala 
1               5                   10                  15      


Ala Ser Tyr Ser Glu Thr Val Thr Cys Glu Asp Ala Gln Lys Thr Cys 
            20                  25                  30          


Pro Ala Val Ile Ala Cys Ser Ser Pro Gly Ile Asn Gly Phe Pro Gly 
        35                  40                  45              


Lys Asp Gly Arg Asp Gly Thr Lys Gly Glu Lys Gly Glu Pro Gly Gln 
    50                  55                  60                  


Gly Leu Arg Gly Leu Gln Gly Pro Pro Gly Lys Leu Gly Pro Pro Gly 
65                  70                  75                  80  


Asn Pro Gly Pro Ser Gly Ser Pro Gly Pro Lys Gly Gln Lys Gly Asp 
                85                  90                  95      


Pro Gly Lys Ser Pro Asp Gly Asp Ser Ser Leu Ala Ala Ser Glu Arg 
            100                 105                 110         


Lys Ala Leu Gln Thr Glu Met Ala Arg Ile Lys Lys Trp Leu Thr Phe 
        115                 120                 125             


Ser Leu Gly Lys Gln Val Gly Asn Lys Phe Phe Leu Thr Asn Gly Glu 
    130                 135                 140                 


Ile Met Thr Phe Glu Lys Val Lys Ala Leu Cys Val Lys Phe Gln Ala 
145                 150                 155                 160 


Ser Val Ala Thr Pro Arg Asn Ala Ala Glu Asn Gly Ala Ile Gln Asn 
                165                 170                 175     


Leu Ile Lys Glu Glu Ala Phe Leu Gly Ile Thr Asp Glu Lys Thr Glu 
            180                 185                 190         


Gly Gln Phe Val Asp Leu Thr Gly Asn Arg Leu Thr Tyr Thr Asn Trp 
        195                 200                 205             


Asn Glu Gly Glu Pro Asn Asn Ala Gly Ser Asp Glu Asp Cys Val Leu 
    210                 215                 220                 


Leu Leu Lys Asn Gly Gln Trp Asn Asp Val Pro Cys Ser Thr Ser His 
225                 230                 235                 240 


Leu Ala Val Cys Glu Phe Pro Ile Gly Gly Gly Gly Gly Gly Gly Gly 
                245                 250                 255     


Gly Gly Gly Gly Met Ser Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu 
            260                 265                 270         


Ser Met Val Ala Ala Ser Tyr Ser Glu Thr Val Thr Cys Glu Asp Ala 
        275                 280                 285             


Gln Lys Thr Cys Pro Ala Val Ile Ala Cys Ser Ser Pro Gly Ile Asn 
    290                 295                 300                 


Gly Phe Pro Gly Lys Asp Gly Arg Asp Gly Thr Lys Gly Glu Lys Gly 
305                 310                 315                 320 


Glu Pro Gly Gln Gly Leu Arg Gly Leu Gln Gly Pro Pro Gly Lys Leu 
                325                 330                 335     


Gly Pro Pro Gly Asn Pro Gly Pro Ser Gly Ser Pro Gly Pro Lys Gly 
            340                 345                 350         


Gln Lys Gly Asp Pro Gly Lys Ser Pro Asp Gly Asp Ser Ser Leu Ala 
        355                 360                 365             


Ala Ser Glu Arg Lys Ala Leu Gln Thr Glu Met Ala Arg Ile Lys Lys 
    370                 375                 380                 


Trp Leu Thr Phe Ser Leu Gly Lys Gln Val Gly Asn Lys Phe Phe Leu 
385                 390                 395                 400 


Thr Asn Gly Glu Ile Met Thr Phe Glu Lys Val Lys Ala Leu Cys Val 
                405                 410                 415     


Lys Phe Gln Ala Ser Val Ala Thr Pro Arg Asn Ala Ala Glu Asn Gly 
            420                 425                 430         


Ala Ile Gln Asn Leu Ile Lys Glu Glu Ala Phe Leu Gly Ile Thr Asp 
        435                 440                 445             


Glu Lys Thr Glu Gly Gln Phe Val Asp Leu Thr Gly Asn Arg Leu Thr 
    450                 455                 460                 


Tyr Thr Asn Trp Asn Glu Gly Glu Pro Asn Asn Ala Gly Ser Asp Glu 
465                 470                 475                 480 


Asp Cys Val Leu Leu Leu Lys Asn Gly Gln Trp Asn Asp Val Pro Cys 
                485                 490                 495     


Ser Thr Ser His Leu Ala Val Cys Glu Phe Pro Ile Gly Gly Gly Gly 
            500                 505                 510         


Gly Gly Gly Gly Gly Gly Gly Gly Met Ser Leu Phe Pro Ser Leu Pro 
        515                 520                 525             


Leu Leu Leu Leu Ser Met Val Ala Ala Ser Tyr Ser Glu Thr Val Thr 
    530                 535                 540                 


Cys Glu Asp Ala Gln Lys Thr Cys Pro Ala Val Ile Ala Cys Ser Ser 
545                 550                 555                 560 


Pro Gly Ile Asn Gly Phe Pro Gly Lys Asp Gly Arg Asp Gly Thr Lys 
                565                 570                 575     


Gly Glu Lys Gly Glu Pro Gly Gln Gly Leu Arg Gly Leu Gln Gly Pro 
            580                 585                 590         


Pro Gly Lys Leu Gly Pro Pro Gly Asn Pro Gly Pro Ser Gly Ser Pro 
        595                 600                 605             


Gly Pro Lys Gly Gln Lys Gly Asp Pro Gly Lys Ser Pro Asp Gly Asp 
    610                 615                 620                 


Ser Ser Leu Ala Ala Ser Glu Arg Lys Ala Leu Gln Thr Glu Met Ala 
625                 630                 635                 640 


Arg Ile Lys Lys Trp Leu Thr Phe Ser Leu Gly Lys Gln Val Gly Asn 
                645                 650                 655     


Lys Phe Phe Leu Thr Asn Gly Glu Ile Met Thr Phe Glu Lys Val Lys 
            660                 665                 670         


Ala Leu Cys Val Lys Phe Gln Ala Ser Val Ala Thr Pro Arg Asn Ala 
        675                 680                 685             


Ala Glu Asn Gly Ala Ile Gln Asn Leu Ile Lys Glu Glu Ala Phe Leu 
    690                 695                 700                 


Gly Ile Thr Asp Glu Lys Thr Glu Gly Gln Phe Val Asp Leu Thr Gly 
705                 710                 715                 720 


Asn Arg Leu Thr Tyr Thr Asn Trp Asn Glu Gly Glu Pro Asn Asn Ala 
                725                 730                 735     


Gly Ser Asp Glu Asp Cys Val Leu Leu Leu Lys Asn Gly Gln Trp Asn 
            740                 745                 750         


Asp Val Pro Cys Ser Thr Ser His Leu Ala Val Cys Glu Phe Pro Ile 
        755                 760                 765             


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Met Ser Leu Phe 
    770                 775                 780                 


Pro Ser Leu Pro Leu Leu Leu Leu Ser Met Val Ala Ala Ser Tyr Ser 
785                 790                 795                 800 


Glu Thr Val Thr Cys Glu Asp Ala Gln Lys Thr Cys Pro Ala Val Ile 
                805                 810                 815     


Ala Cys Ser Ser Pro Gly Ile Asn Gly Phe Pro Gly Lys Asp Gly Arg 
            820                 825                 830         


Asp Gly Thr Lys Gly Glu Lys Gly Glu Pro Gly Gln Gly Leu Arg Gly 
        835                 840                 845             


Leu Gln Gly Pro Pro Gly Lys Leu Gly Pro Pro Gly Asn Pro Gly Pro 
    850                 855                 860                 


Ser Gly Ser Pro Gly Pro Lys Gly Gln Lys Gly Asp Pro Gly Lys Ser 
865                 870                 875                 880 


Pro Asp Gly Asp Ser Ser Leu Ala Ala Ser Glu Arg Lys Ala Leu Gln 
                885                 890                 895     


Thr Glu Met Ala Arg Ile Lys Lys Trp Leu Thr Phe Ser Leu Gly Lys 
            900                 905                 910         


Gln Val Gly Asn Lys Phe Phe Leu Thr Asn Gly Glu Ile Met Thr Phe 
        915                 920                 925             


Glu Lys Val Lys Ala Leu Cys Val Lys Phe Gln Ala Ser Val Ala Thr 
    930                 935                 940                 


Pro Arg Asn Ala Ala Glu Asn Gly Ala Ile Gln Asn Leu Ile Lys Glu 
945                 950                 955                 960 


Glu Ala Phe Leu Gly Ile Thr Asp Glu Lys Thr Glu Gly Gln Phe Val 
                965                 970                 975     


Asp Leu Thr Gly Asn Arg Leu Thr Tyr Thr Asn Trp Asn Glu Gly Glu 
            980                 985                 990         


Pro Asn Asn Ala Gly Ser Asp Glu  Asp Cys Val Leu Leu  Leu Lys Asn 
        995                 1000                 1005             


Gly Gln  Trp Asn Asp Val Pro  Cys Ser Thr Ser His  Leu Ala Val 
    1010                 1015                 1020             


Cys Glu  Phe Pro Ile 
    1025             


<210>  9
<211>  10497
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  minicircle DNA encoding recombinant protein MBL-2 - L - MBL-2 - L -  
       MBL-2 - MBL-2 - MASP2 - MASP2

<400>  9
gccagggcgt gcccttgggc tccccgggcg cgactagtga attgatacta gtaaggatct       60

gcgatcgctc cggtgcccgt cagtgggcag agcgcacatc gcccacagtc cccgagaagt      120

tggggggagg ggtcggcaat tgaacgggtg cctagagaag gtggcgcggg gtaaactggg      180

aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg tgggggagaa ccgtatataa      240

gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt tgccgccaga acacagctga      300

agcttcgagg ggctcgcatc tctccttcac gcgcccgccg ccctacctga ggccgccatc      360

cacgccggtt gagtcgcgtt ctgccgcctc ccgcctgtgg tgcctcctga actgcgtccg      420

ccgtctaggt aagtttaaag ctcaggtcga gaccgggcct ttgtccggcg ctcccttgga      480

gcctacctag actcagccgg ctctccacgc tttgcctgac cctgcttgct caactctacg      540

tctttgtttc gttttctgtt ctgcgccgtt acagatccaa gctgtgaccg gcgcctactc      600

tagagctagc gaattcgcca ccatgtccct gttcccatct ctgccactgc tgctgctgag      660

catggtggca gccagctact ccgagaccgt gacatgcgag gacgcacaga agacctgccc      720

tgccgtgatc gcctgtagct cccctggcat caacggcttt ccaggcaagg acggccggga      780

tggcacaaag ggagagaagg gagagccagg acagggactg agaggcctgc agggaccacc      840

tggcaagctg ggaccaccag gaaatccagg accatctggc agccctggac caaagggaca      900

gaagggcgat cccggcaagt cccctgacgg cgattctagc ctggcagcat ctgagaggaa      960

ggccctgcag accgagatgg ccagaatcaa gaagtggctg acattcagcc tgggcaagca     1020

agtgggcaac aagttctttc tgaccaatgg cgagatcatg acattcgaga aggtgaaggc     1080

cctgtgcgtg aagtttcagg catccgtggc aaccccaagg aacgcagccg agaatggcgc     1140

catccagaac ctgatcaagg aggaggcctt cctgggcatc accgacgaga agacagaggg     1200

ccagtttgtg gatctgacag gcaatagact gacctacaca aactggaatg agggcgagcc     1260

taacaatgcc ggcagcgacg aggattgcgt gctgctgctg aagaacggcc agtggaatga     1320

cgtgccatgc tccacctctc acctggccgt gtgcgagttc cccatcggag gcggcggcgg     1380

cggcggaggc gggggcggcg gcatgagcct gtttccttcc ctgcctctgc tgctgctgtc     1440

catggtggcc gccagctatt ccgagaccgt gacatgtgag gatgcacaga agacctgccc     1500

agccgtgatc gcatgttcct ctccaggcat caacggcttc cctggcaagg acggcaggga     1560

tggcacaaag ggcgagaagg gagagcctgg acagggactg aggggactgc agggccctcc     1620

aggcaagctg ggaccacctg gaaatccagg accttctggc agcccaggcc ctaagggaca     1680

gaagggcgac ccaggcaaga gcccagacgg cgatagctcc ctggcagcat ccgaaagaaa     1740

ggccctgcag actgaaatgg cccgcatcaa gaagtggctg accttcagct taggcaagca     1800

agtcggaaac aagttctttc tgactaacgg agaaattatg acattcgaga aagtcaaggc     1860

cctgtgcgtg aaattccagg ccagcgtcgc cactcctaga aatgccgctg aaaacggagc     1920

tattcagaac ctgatcaagg aagaagcctt cctgggaatt actgatgaaa aaaccgaagg     1980

acagttcgtc gatctgacag gcaatcgcct gacttatacc aattggaacg aaggagaacc     2040

aaataacgct ggcagcgatg aagactgcgt gctgctgctg aagaatggac agtggaacga     2100

cgtgccttgt tccacctctc acctggccgt gtgcgagttc ccgattggcg ggggcggggg     2160

cggcggcggc gggggaggag gcatgtctct gtttcccagt ctgcccctgc tgctgctgtc     2220

tatggtggcc gcttcctata gcgaaactgt cacatgtgag gatgcccaga aaacttgccc     2280

agccgtgatc gcctgttcta gcccaggcat caacggattc ccaggcaagg acggaaggga     2340

tggaaccaaa ggcgaaaaag gcgaacctgg ccagggcctg agaggcctgc agggcccacc     2400

cggcaagctg ggccctccag gaaatcctgg accatctggc agcccaggac ccaaaggaca     2460

gaagggcgac cctggcaagt ctccagacgg cgattcctct ctggcagcaa gcgaacgcaa     2520

ggccctgcag actgagatgg ctagaatcaa gaagtggctg accttcagcc ttggcaagca     2580

agtcgggaac aagttctttc tgacaaacgg agaaatcatg acattcgaga aagttaaggc     2640

cctgtgcgtg aagttccagg ccagcgtcgc tactcctaga aatgccgcag aaaacggagc     2700

tatacaaaac ctgatcaagg aagaggcctt cctgggaatt acagatgaaa aaaccgaagg     2760

gcagttcgtg gatctgaccg gaaacaggct gacttatacc aactggaacg aaggagaacc     2820

caataacgct ggcagcgacg aagactgcgt gctgctgctg aagaacggtc agtggaatga     2880

cgtgccctgc tccacctctc acctggccgt gtgcgagttc cctatcatgt ccctgtttcc     2940

tagcttacct ttattactgc tgagcatggt cgccgcttcc tacagcgaaa ctgtgacctg     3000

tgaggatgcc cagaagactt gtcccgccgt gatcgcttgc tccagcccag gcatcaacgg     3060

gtttcctggc aaggatggaa gagacggaac aaagggcgag aagggcgaac ctggccaggg     3120

gctgagggga ctgcaggggc ctcccggcaa gctgggcccc cctggcaacc ccggcccttc     3180

cggcagcccc ggccccaaag gccagaaggg cgaccccggc aagagcccag atggcgattc     3240

ctccctggcc gcctccgaaa ggaaggccct gcaaactgaa atggctcgca tcaagaagtg     3300

gctgacattc agcttaggca agcaagtagg taacaagttc tttctgacga acggagagat     3360

tatgacattc gagaaggtca aggccctgtg cgtgaagttt caagccagcg tcgccacccc     3420

aaggaacgca gcagaaaacg gagctatcca aaacctgatc aaggaggaag ccttcctggg     3480

aatcactgat gaaaaaaccg agggacagtt cgtggatctg actggcaatc gcctgactta     3540

caccaattgg aacgagggcg agcccaataa cgcaggcagc gatgaagatt gcgtgctgct     3600

gctgaagaac ggacagtgga atgacgtgcc ttgctccacc tctcacctgg ccgtgtgcga     3660

gttcccaatc atgaggctgc tgaccctgct gggactgctg tgcggctctg tggcaacacc     3720

tctgggacca aagtggccag agcccgtgtt cggcagactg gcaagcccag gatttcctgg     3780

agagtacgcc aacgatcagg agcggagatg gaccctgaca gcacctccag gatacaggct     3840

gagactgtat ttcacccact ttgacctgga gctgagccac ctgtgcgagt acgattttgt     3900

gaagctgtcc tctggagcaa aggtgctggc caccctgtgc ggacaggagt ctaccgacac     3960

agagcgggcc ccaggcaagg ataccttcta tagcctgggc agctccctgg acatcacctt     4020

ccggagcgat tacagcaacg agaagccctt caccggcttt gaggccttct atgccgccga     4080

ggacatcgat gagtgccagg tggcaccagg agaggcacca acatgcgacc accactgtca     4140

caaccacctg ggcggcttct actgctcttg tagggccggc tatgtgctgc accggaataa     4200

gagaacctgc agcgccctgt gctccggaca ggtgtttaca cagcggagcg gagagctgtc     4260

tagcccagag tacccaagac cctatcctaa gctgtcctct tgtacctaca gcatctccct     4320

ggaggagggc ttctccgtga tcctggactt cgtggagtct tttgatgtgg agacccaccc     4380

cgagacactg tgcccttatg acttcctgaa gatccagacc gatcgggagg agcacggccc     4440

cttttgtggc aagaccctgc ctcacagaat cgagacaaag tctaacaccg tgacaatcac     4500

ctttgtgacc gacgagagcg gcgatcacac aggctggaag atccactaca catccaccgc     4560

ccagccatgc ccctatccta tggcaccacc taatggacac gtgagcccag tgcaggccaa     4620

gtacatcctg aaggactctt ttagcatctt ctgcgagacc ggctatgagc tgctgcaggg     4680

ccacctgcct ctgaagtcct tcacagccgt gtgccagaag gacggcagct gggataggcc     4740

aatgccagca tgctccatcg tggattgtgg cccacccgac gatctgcctt ccggcagagt     4800

ggagtacatc accggcccag gcgtgaccac atacaaggcc gtgatccagt attcttgcga     4860

ggagaccttc tacacaatga aggtgaacga cggcaagtac gtgtgcgagg ccgatggctt     4920

ttggaccagc tccaagggag agaagagcct gcccgtgtgc gagcccgtgt gcggactgtc     4980

cgcccggacc acaggcggca gaatctatgg aggacagaag gcaaagccag gcgacttccc     5040

ttggcaggtg ctgatcctgg gaggaaccac agcagcaggc gccctgctgt acgataactg     5100

ggtgctgacc gcagcacacg ccgtgtatga gcagaagcac gacgccagcg ccctggatat     5160

ccggatgggc accctgaaga gactgagccc ccactacaca caggcctggt ccgaggccgt     5220

gttcatccac gagggctata cccacgacgc cggctttgac aatgatatcg ccctgatcaa     5280

gctgaacaat aaggtggtca tcaactccaa tatcacacca atctgcctgc cccggaagga     5340

ggccgagtct ttcatgagaa ccgacgatat cggcacagca agcggatggg gactgaccca     5400

gaggggcttt ctggcacgca acctgatgta cgtggacatc cctatcgtgg atcaccagaa     5460

gtgtaccgcc gcctacgaga agcctccata tccacggggc tctgtgacag ccaatatgct     5520

gtgcgcagga ctggagtccg gaggcaagga ctcttgtagg ggcgatagcg gaggcgccct     5580

ggtgttcctg gacagcgaga ccgagagatg gtttgtgggc ggcatcgtgt cctggggctc     5640

tatgaactgc ggagaggcag gacagtacgg cgtgtataca aaagtgatca actacatccc     5700

ctggatcgag aatatcatca gcgacttcat gagactgctg accctgctgg gcctgctgtg     5760

cggctccgtg gcaacaccac tgggaccaaa gtggcctgag ccagtgttcg gccgcctggc     5820

aagccctgga tttccaggcg agtatgccaa tgatcaggag aggcgctgga cactgaccgc     5880

accacctgga tacaggctga ggctgtactt cacccacttc gacctggagc tgtctcacct     5940

gtgcgaatat gactttgtga agctgtctag cggcgccaaa gtcctggcca ccctgtgcgg     6000

ccaggagtcc acagacaccg agagggcccc tggcaaggac accttctatt ctctgggctc     6060

ctctctggac atcacatttc gcagcgatta ctctaatgaa aaacccttca ccggcttcga     6120

ggccttttat gctgctgaag atattgacga gtgccaggtg gcacctggcg aagcccctac     6180

ctgtgatcat cattgccata atcacctggg aggcttctac tgctcctgta gagctggata     6240

tgtgctgcac aggaataaga ggacttgtag cgccctgtgc agtggccagg tgtttacaca     6300

gaggtctgga gagctgagct ccccagagta cccaaggcct tatccaaagc tgtctagctg     6360

tacctactcc atctctctgg aggagggctt ctctgtgatc ctggattttg tggagagctt     6420

tgatgtggaa actcacccag agacactgtg cccctacgac ttcctgaaaa tccagaccga     6480

tagggaggag cacggcccat tctgcggcaa gaccctgccc caccgcattg aaacaaagtc     6540

taacacagtg accatcacat ttgtgactga tgaatccggc gatcataccg gatggaaaat     6600

ccactacacc tccacagccc agccctgccc ttatccaatg gccccaccca atggccacgt     6660

gtcccctgtc caggctaaat acatcctgaa ggacagcttc tccatctttt gcgaaactgg     6720

atacgaactg ctgcagggac acctgcccct gaagtctttc acagccgtgt gccaaaagga     6780

cggctcttgg gataggccca tgcctgcctg cagcatcgtg gattgtggac ctccagacga     6840

tctgccaagc ggaagggtgg agtacatcac cggacctgga gtcactacct ataaagccgt     6900

gatccagtat tcctgtgaag agaccttcta caccatgaaa gtcaatgatg gcaagtacgt     6960

gtgcgaagct gacggctttt ggacctcctc taagggagag aagtctctgc ccgtgtgcga     7020

acccgtgtgc ggactgtctg ccagaactac cggaggcaga atctatggcg gccagaaggc     7080

caagccaggc gacttcccat ggcaggtcct gatcctgggc ggcactaccg ccgccggcgc     7140

cctgctgtat gacaattggg tcctgactgc cgcccatgcc gtgtatgaac agaaacatga     7200

tgctagcgcc ctggacatca ggatgggcac cctgaagcgc ctgtccccac attatacaca     7260

ggcctggtct gaagccgtgt tcatccatga aggatacact catgatgctg gattcgataa     7320

cgacatcgcc ctgatcaagc tgaacaataa ggtggtcatc aacagcaata tcacacctat     7380

ctgcctgcca aggaaggagg ccgagagctt catgcgcact gatgatatcg gcacagcatc     7440

tggctggggc ctgactcaga gaggctttct ggccagaaac ctgatgtatg tggacatccc     7500

cattgtcgac catcagaaat gcactgctgc ctacgagaag cccccttatc ctagaggcag     7560

cgtcaccgct aacatgctgt gcgccggcct ggaaagcggc ggcaaggatt cctgcagagg     7620

cgattccggc ggcgccctgg tgttcctgga ttccgagacc gagcggtggt tcgtcggcgg     7680

catcgtgtct tggggcagca tgaattgtgg cgaagccggc cagtatggcg tgtataccaa     7740

agtgatcaac tatattcctt ggattgagaa tatcatcagc gatttctgag gatccgcggc     7800

cgcgcccctc tccctccccc ccccctaacg ttactggccg aagccgcttg gaataaggcc     7860

ggtgtgcgtt tgtctatatg ttattttcca ccatattgcc gtcttttggc aatgtgaggg     7920

cccggaaacc tggccctgtc ttcttgacga gcattcctag gggtctttcc cctctcgcca     7980

aaggaatgca aggtctgttg aatgtcgtga aggaagcagt tcctctggaa gcttcttgaa     8040

gacaaacaac gtctgtagcg accctttgca ggcagcggaa ccccccacct ggcgacaggt     8100

gcctctgcgg ccaaaagcca cgtgtataag atacacctgc aaaggcggca caaccccagt     8160

gccacgttgt gagttggata gttgtggaaa gagtcaaatg gctctcctca agcgtattca     8220

acaaggggct gaaggatgcc cagaaggtac cccattgtat gggatctgat ctggggcctc     8280

ggtgcacatg ctttacatgt gtttagtcga ggttaaaaaa acgtctaggc cccccgaacc     8340

acggggacgt ggttttcctt tgaaaaacac gataatacct ccggaatgga gagcgacgag     8400

agcggcctgc ccgccatgga gatcgagtgc cgcatcaccg gcaccctgaa cggcgtggag     8460

ttcgagctgg tgggcggcgg agagggcacc cccaagcagg gccgcatgac caacaagatg     8520

aagagcacca aaggcgccct gaccttcagc ccctacctgc tgagccacgt gatgggctac     8580

ggcttctacc acttcggcac ctaccccagc ggctacgaga accccttcct gcacgccatc     8640

aacaacggcg gctacaccaa cacccgcatc gagaagtacg aggacggcgg cgtgctgcac     8700

gtgagcttca gctaccgcta cgaggccggc cgcgtgatcg gcgacttcaa ggtggtgggc     8760

accggcttcc ccgaggacag cgtgatcttc accgacaaga tcatccgcag caacgccacc     8820

gtggagcacc tgcaccccat gggcgataac gtgctggtgg gcagcttcgc ccgcaccttc     8880

agcctgcgcg acggcggcta ctacagcttc gtggtggaca gccacatgca cttcaagagc     8940

gccatccacc ccagcatcct gcagaacggg ggccccatgt tcgccttccg ccgcgtggag     9000

gagctgcaca gcaacaccga gctgggcatc gtggagtacc agcacgcctt caagaccccc     9060

atcgccttcg ccagatcccg cgctcagtcg tccaattctg ccgtggacgg caccgccgga     9120

cccggctcca ccggatctcg ctagagctga atctaagtcg acaatcaacc tctggattac     9180

aaaatttgtg aaagattgac tggtattctt aactatgttg ctccttttac gctatgtgga     9240

tacgctgctt taatgccttt gtatcatgct attgcttccc gtatggcttt cattttctcc     9300

tccttgtata aatcctggtt gctgtctctt tatgaggagt tgtggcccgt tgtcaggcaa     9360

cgtggcgtgg tgtgcactgt gtttgctgac gcaaccccca ctggttgggg cattgccacc     9420

acctgtcagc tcctttccgg gactttcgct ttccccctcc ctattgccac ggcggaactc     9480

atcgccgcct gccttgcccg ctgctggaca ggggctcggc tgttgggcac tgacaattcc     9540

gtggtgttgt cggggaaatc atcgtccttt ccttggctgc tcgcctgtgt tgccacctgg     9600

attctgcgcg ggacgtcctt ctgctacgtc ccttcggccc tcaatccagc ggaccttcct     9660

tcccgcggcc tgctgccggc tctgcggcct cttccgcgtc ttcgccttcg ccctcagacg     9720

agtcggatct ccctttgggc cgcctccccg cctggtacct ttaagaccaa tgacttacaa     9780

ggcagctgta gatcttagcc actttttaaa agaaaagggg ggactggaag ggctaattca     9840

ctcccaacga agataagatc tgctttttgc ttgtactggg tctctctggt tagaccagat     9900

ctgagcctgg gagctctctg gctaactagg gaacccactg cttaagcctc aataaagctt     9960

gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt gactctggta actagagatc    10020

cctcagaccc ttttagtcag tgtggaaaat ctctagcagt agtagttcat gtcatcttat    10080

tattcagtat ttataacttg caaagaaatg aatatcagag agtgagagga acttgtttat    10140

tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt    10200

tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg    10260

gctctagcta tcccgcccct aactccgccc atcccgcccc taactccgcc cagttccgcc    10320

cattctccgc cccatggctg actaattttt tttatttatg cagaggccga ggccgcctcg    10380

gcctctgagc tattccagaa gtagtgagga ggcttttttg gaggcctaga cttttgcaga    10440

tcgacccatg ggggcccgcc ccaactgggg taacctttga gttctctcag ttggggg       10497


<210>  10
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu Ser Met Val Ala 
1               5                   10                  15      


Ala Ser Tyr Ser Glu Thr Val Thr Cys Glu Asp Ala Gln Lys Thr Cys 
            20                  25                  30          


Pro Ala Val Ile Ala Cys Ser Ser Pro Gly Ile Asn Gly Phe Pro Gly 
        35                  40                  45              


Lys Asp Gly Arg Asp Gly Thr Lys Gly Glu Lys Gly Glu Pro Gly Gln 
    50                  55                  60                  


Gly Leu Arg Gly Leu Gln Gly Pro Pro Gly Lys Leu Gly Pro Pro Gly 
65                  70                  75                  80  


Asn Pro Gly Pro Ser Gly Ser Pro Gly Pro Lys Gly Gln Lys Gly Asp 
                85                  90                  95      


Pro Gly Lys Ser Pro Asp Gly Asp Ser Ser Leu Ala Ala Ser Glu Arg 
            100                 105                 110         


Lys Ala Leu Gln Thr Glu Met Ala Arg Ile Lys Lys Trp Leu Thr Phe 
        115                 120                 125             


Ser Leu Gly Lys Gln Val Gly Asn Lys Phe Phe Leu Thr Asn Gly Glu 
    130                 135                 140                 


Ile Met Thr Phe Glu Lys Val Lys Ala Leu Cys Val Lys Phe Gln Ala 
145                 150                 155                 160 


Ser Val Ala Thr Pro Arg Asn Ala Ala Glu Asn Gly Ala Ile Gln Asn 
                165                 170                 175     


Leu Ile Lys Glu Glu Ala Phe Leu Gly Ile Thr Asp Glu Lys Thr Glu 
            180                 185                 190         


Gly Gln Phe Val Asp Leu Thr Gly Asn Arg Leu Thr Tyr Thr Asn Trp 
        195                 200                 205             


Asn Glu Gly Glu Pro Asn Asn Ala Gly Ser Asp Glu Asp Cys Val Leu 
    210                 215                 220                 


Leu Leu Lys Asn Gly Gln Trp Asn Asp Val Pro Cys Ser Thr Ser His 
225                 230                 235                 240 


Leu Ala Val Cys Glu Phe Pro Ile 
                245             


<210>  11
<211>  686
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Arg Leu Leu Thr Leu Leu Gly Leu Leu Cys Gly Ser Val Ala Thr 
1               5                   10                  15      


Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala Ser 
            20                  25                  30          


Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp Thr 
        35                  40                  45              


Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60                  


Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu Ser 
65                  70                  75                  80  


Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95      


Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser Ser 
            100                 105                 110         


Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125             


Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln Val 
    130                 135                 140                 


Ala Pro Gly Glu Ala Pro Thr Cys Asp His His Cys His Asn His Leu 
145                 150                 155                 160 


Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg Asn 
                165                 170                 175     


Lys Arg Thr Cys Ser Ala Leu Cys Ser Gly Gln Val Phe Thr Gln Arg 
            180                 185                 190         


Ser Gly Glu Leu Ser Ser Pro Glu Tyr Pro Arg Pro Tyr Pro Lys Leu 
        195                 200                 205             


Ser Ser Cys Thr Tyr Ser Ile Ser Leu Glu Glu Gly Phe Ser Val Ile 
    210                 215                 220                 


Leu Asp Phe Val Glu Ser Phe Asp Val Glu Thr His Pro Glu Thr Leu 
225                 230                 235                 240 


Cys Pro Tyr Asp Phe Leu Lys Ile Gln Thr Asp Arg Glu Glu His Gly 
                245                 250                 255     


Pro Phe Cys Gly Lys Thr Leu Pro His Arg Ile Glu Thr Lys Ser Asn 
            260                 265                 270         


Thr Val Thr Ile Thr Phe Val Thr Asp Glu Ser Gly Asp His Thr Gly 
        275                 280                 285             


Trp Lys Ile His Tyr Thr Ser Thr Ala Gln Pro Cys Pro Tyr Pro Met 
    290                 295                 300                 


Ala Pro Pro Asn Gly His Val Ser Pro Val Gln Ala Lys Tyr Ile Leu 
305                 310                 315                 320 


Lys Asp Ser Phe Ser Ile Phe Cys Glu Thr Gly Tyr Glu Leu Leu Gln 
                325                 330                 335     


Gly His Leu Pro Leu Lys Ser Phe Thr Ala Val Cys Gln Lys Asp Gly 
            340                 345                 350         


Ser Trp Asp Arg Pro Met Pro Ala Cys Ser Ile Val Asp Cys Gly Pro 
        355                 360                 365             


Pro Asp Asp Leu Pro Ser Gly Arg Val Glu Tyr Ile Thr Gly Pro Gly 
    370                 375                 380                 


Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr Ser Cys Glu Glu Thr Phe 
385                 390                 395                 400 


Tyr Thr Met Lys Val Asn Asp Gly Lys Tyr Val Cys Glu Ala Asp Gly 
                405                 410                 415     


Phe Trp Thr Ser Ser Lys Gly Glu Lys Ser Leu Pro Val Cys Glu Pro 
            420                 425                 430         


Val Cys Gly Leu Ser Ala Arg Thr Thr Gly Gly Arg Ile Tyr Gly Gly 
        435                 440                 445             


Gln Lys Ala Lys Pro Gly Asp Phe Pro Trp Gln Val Leu Ile Leu Gly 
    450                 455                 460                 


Gly Thr Thr Ala Ala Gly Ala Leu Leu Tyr Asp Asn Trp Val Leu Thr 
465                 470                 475                 480 


Ala Ala His Ala Val Tyr Glu Gln Lys His Asp Ala Ser Ala Leu Asp 
                485                 490                 495     


Ile Arg Met Gly Thr Leu Lys Arg Leu Ser Pro His Tyr Thr Gln Ala 
            500                 505                 510         


Trp Ser Glu Ala Val Phe Ile His Glu Gly Tyr Thr His Asp Ala Gly 
        515                 520                 525             


Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu Asn Asn Lys Val Val Ile 
    530                 535                 540                 


Asn Ser Asn Ile Thr Pro Ile Cys Leu Pro Arg Lys Glu Ala Glu Ser 
545                 550                 555                 560 


Phe Met Arg Thr Asp Asp Ile Gly Thr Ala Ser Gly Trp Gly Leu Thr 
                565                 570                 575     


Gln Arg Gly Phe Leu Ala Arg Asn Leu Met Tyr Val Asp Ile Pro Ile 
            580                 585                 590         


Val Asp His Gln Lys Cys Thr Ala Ala Tyr Glu Lys Pro Pro Tyr Pro 
        595                 600                 605             


Arg Gly Ser Val Thr Ala Asn Met Leu Cys Ala Gly Leu Glu Ser Gly 
    610                 615                 620                 


Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly Ala Leu Val Phe Leu 
625                 630                 635                 640 


Asp Ser Glu Thr Glu Arg Trp Phe Val Gly Gly Ile Val Ser Trp Gly 
                645                 650                 655     


Ser Met Asn Cys Gly Glu Ala Gly Gln Tyr Gly Val Tyr Thr Lys Val 
            660                 665                 670         


Ile Asn Tyr Ile Pro Trp Ile Glu Asn Ile Ile Ser Asp Phe 
        675                 680                 685    


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MBL2-Internal qPCR primer

<400>  12
ccctgtttcc atcactccct c                                                 21


<210>  13
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MBL2- Internal qPCR primer

<400>  13
gcaggtcttt tgggcatcc                                                    19


<210>  14
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MBL2- Internal qPCR primer

<400>  14
tagtagcctg gctgcctcag aa                                                22


<210>  15
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MBL2- Internal qPCR primer

<400>  15
caccattggt caggaagaac ttg                                               23


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MASP2 - Internal qPCR primer

<400>  16
tccaggggag tatgccaatg a                                                 21


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MASP2 - Internal qPCR primer

<400>  17
tccaggtcga agtgggtgaa                                                   20


<210>  18
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MASP2- Internal qPCR primer

<400>  18
ctggcaagga cactttctac tc                                                22


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MASP2 - Internal qPCR primer

<400>  19
tgaacggctt ctcgttggag                                                   20


<210>  20
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MBL2-Cross-liner primer

<400>  20
caggcaatag actgacctac ac                                                22


<210>  21
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MBL2-Cross-liner primer

<400>  21
gaagaacggc cagtggaat                                                    19


<210>  22
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MBL2-Cross-liner primer

<400>  22
aggcaatcgc ctgacttata c                                                 21


<210>  23
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MBL2-Cross-liner primer

<400>  23
gaagaatgga cagtggaacg a                                                 21


<210>  24
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAPDH primer

<400>  24
gtctcctctg acttcaacag cg                                                22


<210>  25
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAPDH primer

<400>  25
gtctcctctg acttcaacag cg                                                22




