﻿                            SEQUENCE LISTING

<110> Shieh, Dar-Bin

<120> METHOD FOR MODULATING TUMOR MICROENVIRONMENT TOWARD ANTI-CANCER
      PHENOTYPE IN A SUBJECT IN NEED THEREOF USING NANO-MODULATOR AND 
      APPLICATIONS THEREOF 
      
<130> None

<160> 58



<210> 1
<211> 21
<212> DNA
<213> Artificial sequence

<220>
<223> forward primer of human β-actin mRNA

<400> 1
ggcggcacca ccatgtaccc t                                             21



<210> 2
<211> 21
<212> DNA
<213> Artificial sequence

<220>
<223> reverse primer of human β-actin mRNA

<400> 2
aggggccgga ctcgtcatac t                                             21



<210> 3
<211> 20
<212> DNA
<213> Artificial sequence

<220>
<223> forward primer of human SLC7A11 mRNA

<400> 3
atgcagtggc agtgaccttt                                               20



<210> 4
<211> 20
<212> DNA
<213> Artificial sequence

<220>
<223> reverse primer of human SLC7A11 mRNA

<400> 4
ggcaacaaag atcggaactg                                               20



<210> 5
<211> 23
<212> DNA
<213> Artificial sequence

<220>
<223> forward primer of human GPX4 mRNA

<400> 5
cagtgaggca agaccgaagt aaa                                           23



<210> 6
<211> 21
<212> DNA
<213> Artificial sequence

<220>
<223> reverse primer of human GPX4 mRNA

<400> 6
tgcttcccga actggttaca c                                             21



<210> 7
<211> 19
<212> DNA
<213> Artificial sequence

<220>
<223> forward primer of human NRF2 gene

<400> 7
acacggtcca cagctcatc                                                19



<210> 8
<211> 22
<212> DNA
<213> Artificial sequence

<220>
<223> reverse primer of human NRF2 gene

<400> 8
tgtcaatcaa atccatgtcc tg                                            22



<210> 9
<211> 24
<212> DNA
<213> Artificial sequence

<220>
<223> forward primer of human AKR1B1 mRNA

<400> 9
taccatgaga agggcctggt gaaa                                          24



<210> 10
<211> 24
<212> DNA
<213> Artificial sequence

<220>
<223> reverse primer of human AKR1B1 mRNA

<400> 10
tccagaatgt tggtgtcact ggga                                          24



<210> 11
<211> 20
<212> DNA
<213> Artificial sequence

<220>
<223> forward primer of human AKR1C1 mRNA

<400> 11
atttgccagc caggctagtg                                               20



<210> 12
<211> 20
<212> DNA
<213> Artificial sequence

<220>
<223> reverse primer of human AKR1C1 mRNA

<400> 12
atttgccagc caggctagtg                                               20



<210> 13
<211> 21
<212> DNA
<213> Artificial sequence

<220>
<223> forward primer of human AKR1C2 mRNA

<400> 13
aagtaaagct ctagaggccg t                                             21



<210> 14
<211> 23
<212> DNA
<213> Artificial sequence

<220>
<223> reverse primer of human AKR1C2 mRNA

<400> 14
gctcctcatt attgtaaaca tgt                                           23



<210> 15
<211> 21
<212> DNA
<213> Artificial sequence

<220>
<223> forward primer of human AKR1C3 mRNA

<400> 15
gggatcaacg agagacaaac g                                             21



<210> 16
<211> 21
<212> DNA
<213> Artificial sequence

<220>
<223> reverse primer of human AKR1C3 mRNA

<400> 16
aaaggactgg gtcctccaag a                                             21



<210> 17
<211> 21
<212> DNA
<213> Artificial sequence

<220>
<223> forward primer of human SLC40A1 mRNA

<400> 17
gcatgggtct tgctttcctt t                                             21



<210> 18
<211> 25
<212> DNA
<213> Artificial sequence

<220>
<223> reverse primer of human SLC40A1 mRNA

<400> 18
aaaatactga ggatggaacc actca                                         25



<210> 19
<211> 20
<212> DNA
<213> Artificial sequence

<220>
<223> forward primer of human Oct4 mRNA

<400> 19
cgaaagagaa agcgaaccag                                               20



<210> 20
<211> 20
<212> DNA
<213> Artificial sequence

<220>
<223> reverse primer of human Oct4 mRNA

<400> 20
gccggttaca gaaccacact                                               20



<210> 21
<211> 18
<212> DNA
<213> Artificial sequence

<220>
<223> forward primer of human Sox2 mRNA

<400> 21
acaactcgga gatcagca                                                 18



<210> 22
<211> 20
<212> DNA
<213> Artificial sequence

<220>
<223> reverse primer of human Sox2 mRNA

<400> 22
gcagcgtgta cttatccttc                                               20



<210> 23
<211> 20
<212> DNA
<213> Artificial sequence

<220>
<223> forward primer of human Nanog mRNA

<400> 23
ctgtgatttg tgggcctgaa                                               20



<210> 24
<211> 23
<212> DNA
<213> Artificial sequence

<220>
<223> reverse primer of human Nanog mRNA

<400> 24
tcttcctttt ttgcgacact ctt                                           23



<210> 25
<211> 21
<212> DNA
<213> Artificial sequence

<220>
<223> forward primer of human Sonic hedgehog mRNA

<400> 25
cccaattaca accccgacat c                                             21



<210> 26
<211> 20
<212> DNA
<213> Artificial sequence

<220>
<223> reverse primer of human Sonic hedgehog mRNA

<400> 26
tcacccgcag tttcactcct                                               20



<210> 27
<211> 21
<212> DNA
<213> Artificial sequence

<220>
<223> forward primer of human TGFβ mRNA

<400> 27
aaagccagag tgcctgaaca a                                             21



<210> 28
<211> 24
<212> DNA
<213> Artificial sequence

<220>
<223> reverse primer of human TGFβ mRNA

<400> 28
aacagcatca gttacatcga agga                                          24



<210> 29
<211> 20
<212> DNA
<213> Artificial sequence

<220>
<223> forward primer of human VEGFA mRNA

<400> 29
tacctccacc atgccaagtg                                               20



<210> 30
<211> 21
<212> DNA
<213> Artificial sequence

<220>
<223> reverse primer of human VEGFA mRNA

<400> 30
tgcgctgata gacatccatg a                                             21



<210> 31
<211> 21
<212> DNA
<213> Artificial sequence

<220>
<223> forward primer of human AIFM2 mRNA

<400> 31
agggttcgcc aaaaagacat t                                             21



<210> 32
<211> 25
<212> DNA
<213> Artificial sequence

<220>
<223> reverse primer of human AIFM2 mRNA

<400> 32
caccatctgg ttcttcaggt ctatc                                         25



<210> 33
<211> 22
<212> DNA
<213> Artificial sequence

<220>
<223> forward primer of human NDUFF4 mRNA

<400> 33
taagagcatt cccaaaggca aa                                            22



<210> 34
<211> 25
<212> DNA
<213> Artificial sequence

<220>
<223> reverse primer of human NDUFF4 mRNA

<400> 34
cattattttc tcagcagtcc aggtt                                         25



<210> 35
<211> 20
<212> DNA
<213> Artificial sequence

<220>
<223> forward primer of human IDH1 mRNA

<400> 35
gtcgtcatgc ttatggggat                                               20



<210> 36
<211> 20
<212> DNA
<213> Artificial sequence

<220>
<223> reverse primer of human IDH1 mRNA

<400> 36
cttttgggtt ccgtcacttg                                               20



<210> 37
<211> 20
<212> DNA
<213> Artificial sequence

<220>
<223> forward primer of human ME1 mRNA

<400> 37
tcttcatgtt catgggcaaa                                               20



<210> 38
<211> 20
<212> DNA
<213> Artificial sequence

<220>
<223> reverse primer of human ME1 mRNA

<400> 38
ggattgcaca cctgattgtg                                               20



<210> 39
<211> 20
<212> DNA
<213> Artificial sequence

<220>
<223> forward primer of human 6PGD mRNA

<400> 39
gtcagtggtg gagaggaagg                                               20



<210> 40
<211> 20
<212> DNA
<213> Artificial sequence

<220>
<223> reverse primer of human 6PGD mRNA

<400> 40
gccttggaag atggtcttga                                               20



<210> 41
<211> 22
<212> DNA
<213> Artificial sequence

<220>
<223> forward primer of human TNFα mRNA

<400> 41
cccagggacc tctctctaat ca                                            22



<210> 42
<211> 19
<212> DNA
<213> Artificial sequence

<220>
<223> reverse primer of human TNFα mRNA

<400> 42
agctgcccct cagcttgag                                                19



<210> 43
<211> 22
<212> DNA
<213> Artificial sequence

<220>
<223> forward primer of human DC-SIGN mRNA

<400> 43
gcagtcttcc agaagtaacc gc                                            22



<210> 44
<211> 23
<212> DNA
<213> Artificial sequence

<220>
<223> reverse primer of human DC-SIGN mRNA

<400> 44
gctctcctct gttccaatac tgc                                           23



<210> 45
<211> 20
<212> DNA
<213> Artificial sequence

<220>
<223> forward primer of human PD-L1 mRNA

<400> 45
gccagaaaag cctcattcgt                                               20



<210> 46
<211> 22
<212> DNA
<213> Artificial sequence

<220>
<223> reverse primer of human PD-L1 mRNA

<400> 46
tgaatctcga aacctccagg aa                                            22



<210> 47
<211> 20
<212> DNA
<213> Artificial sequence

<220>
<223> forward primer of mouse β-actin mRNA

<400> 47
ggctcttttc cagccttcct                                               20



<210> 48
<211> 24
<212> DNA
<213> Artificial sequence

<220>
<223> reverse primer of mouse β-actin mRNA

<400> 48
gtctttacgg atgtcaacgt caca                                            24



<210> 49
<211> 21
<212> DNA
<213> Artificial sequence

<220>
<223> forward primer of mouse iNOS mRNA

<400> 49
tgacgctcgg aactgtagca c                                             21



<210> 50
<211> 19
<212> DNA
<213> Artificial sequence

<220>
<223> reverse primer of mouse iNOS mRNA

<400> 50
tgatggccga cctgatgtt                                                19



<210> 51
<211> 20
<212> DNA
<213> Artificial sequence

<220>
<223> forward primer of mouse Arg1 mRNA

<400> 51
catgggcaac ctgtgtcctt                                               20



<210> 52
<211> 22
<212> DNA
<213> Artificial sequence

<220>
<223> reverse primer of mouse Arg1 mRNA

<400> 52
cgatgtcttt ggcagatatg ca                                            22



<210> 53
<211> 21
<212> DNA
<213> Artificial sequence

<220>
<223> forward primer of human SLC7A11 promoter-ChIP

<400> 53
ttactacttc tggattggct a                                             21



<210> 54
<211> 20
<212> DNA
<213> Artificial sequence

<220>
<223> reverse primer of human SLC7A11 promoter-ChIP

<400> 54
cttgtattta agcgcctgcc                                               20



<210> 55
<211> 21
<212> DNA
<213> Artificial sequence

<220>
<223> forward primer of human AKR1C1 promoter-ChIP

<400> 55
gaatccacca tcttgttgaa a                                             21



<210> 56
<211> 20
<212> DNA
<213> Artificial sequence

<220>
<223> reverse primer of human AKR1C1 promoter-ChIP

<400> 56
acaacttgca gtgccctgat                                               20



<210> 57
<211> 21
<212> DNA
<213> Artificial sequence

<220>
<223> forward primer of human AIFM2 promoter-ChIP

<400> 57
agatggctta tctttcgctg a                                             21



<210> 58
<211> 21
<212> DNA
<213> Artificial sequence

<220>
<223> reverse primer of human AIFM2 promoter-ChIP

<400> 58
tctccaagga tgagaaagag g                                             21







