                         SEQUENCE LISTING

<110>  Brigham Young University
 
<120>  METASTASIS INHIBITING PROTEIN

<130>  82570-356302

<150>  63/177,703
<151>  2021-04-21

<150>  63/274,788
<151>  2021-11-02

<150>  63/296,322
<151>  2022-01-04

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  6933
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of plasmid pET28a CM19XA, followed by amino acid 
       sequence

of "CM19XA" used in this study. pET28a CM19XA

<400>  1
actatatccg gattggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg       60

tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg      120

ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg      180

ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt      240

agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt      300

tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta      360

tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa      420

atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg cttacaattt      480

aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca      540

ttcaaatatg tatccgctca tgaattaatt cttagaaaaa ctcatcgagc atcaaatgaa      600

actgcaattt attcatatca ggattatcaa taccatattt ttgaaaaagc cgtttctgta      660

atgaaggaga aaactcaccg aggcagttcc ataggatggc aagatcctgg tatcggtctg      720

cgattccgac tcgtccaaca tcaatacaac ctattaattt cccctcgtca aaaataaggt      780

tatcaagtga gaaatcacca tgagtgacga ctgaatccgg tgagaatggc aaaagtttat      840

gcatttcttt ccagacttgt tcaacaggcc agccattacg ctcgtcatca aaatcactcg      900

catcaaccaa accgttattc attcgtgatt gcgcctgagc gagacgaaat acgcgatcgc      960

tgttaaaagg acaattacaa acaggaatcg aatgcaaccg gcgcaggaac actgccagcg     1020

catcaacaat attttcacct gaatcaggat attcttctaa tacctggaat gctgttttcc     1080

cggggatcgc agtggtgagt aaccatgcat catcaggagt acggataaaa tgcttgatgg     1140

tcggaagagg cataaattcc gtcagccagt ttagtctgac catctcatct gtaacatcat     1200

tggcaacgct acctttgcca tgtttcagaa acaactctgg cgcatcgggc ttcccataca     1260

atcgatagat tgtcgcacct gattgcccga cattatcgcg agcccattta tacccatata     1320

aatcagcatc catgttggaa tttaatcgcg gcctagagca agacgtttcc cgttgaatat     1380

ggctcataac accccttgta ttactgttta tgtaagcaga cagttttatt gttcatgacc     1440

aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa     1500

ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca     1560

ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta     1620

actggcttca gcagagcgca gataccaaat actgtccttc tagtgtagcc gtagttaggc     1680

caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca     1740

gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta     1800

ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag     1860

cgaacgacct acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt     1920

cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc     1980

acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac     2040

ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac     2100

gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc     2160

tttcctgcgt tatcccctga ttctgtggat aaccgtatta ccgcctttga gtgagctgat     2220

accgctcgcc gcagccgaac gaccgagcgc agcgagtcag tgagcgagga agcggaagag     2280

cgcctgatgc ggtattttct ccttacgcat ctgtgcggta tttcacaccg caatggtgca     2340

ctctcagtac aatctgctct gatgccgcat agttaagcca gtatacactc cgctatcgct     2400

acgtgactgg gtcatggctg cgccccgaca cccgccaaca cccgctgacg cgccctgacg     2460

ggcttgtctg ctcccggcat ccgcttacag acaagctgtg accgtctccg ggagctgcat     2520

gtgtcagagg ttttcaccgt catcaccgaa acgcgcgagg cagctgcggt aaagctcatc     2580

agcgtggtcg tgaagcgatt cacagatgtc tgcctgttca tccgcgtcca gctcgttgag     2640

tttctccaga agcgttaatg tctggcttct gataaagcgg gccatgttaa gggcggtttt     2700

ttcctgtttg gtcactgatg cctccgtgta agggggattt ctgttcatgg gggtaatgat     2760

accgatgaaa cgagagagga tgctcacgat acgggttact gatgatgaac atgcccggtt     2820

actggaacgt tgtgagggta aacaactggc ggtatggatg cggcgggacc agagaaaaat     2880

cactcagggt caatgccagc gcttcgttaa tacagatgta ggtgttccac agggtagcca     2940

gcagcatcct gcgatgcaga tccggaacat aatggtgcag ggcgctgact tccgcgtttc     3000

cagactttac gaaacacgga aaccgaagac cattcatgtt gttgctcagg tcgcagacgt     3060

tttgcagcag cagtcgcttc acgttcgctc gcgtatcggt gattcattct gctaaccagt     3120

aaggcaaccc cgccagccta gccgggtcct caacgacagg agcacgatca tgcgcacccg     3180

tggggccgcc atgccggcga taatggcctg cttctcgccg aaacgtttgg tggcgggacc     3240

agtgacgaag gcttgagcga gggcgtgcaa gattccgaat accgcaagcg acaggccgat     3300

catcgtcgcg ctccagcgaa agcggtcctc gccgaaaatg acccagagcg ctgccggcac     3360

ctgtcctacg agttgcatga taaagaagac agtcataagt gcggcgacga tagtcatgcc     3420

ccgcgcccac cggaaggagc tgactgggtt gaaggctctc aagggcatcg gtcgagatcc     3480

cggtgcctaa tgagtgagct aacttacatt aattgcgttg cgctcactgc ccgctttcca     3540

gtcgggaaac ctgtcgtgcc agctgcatta atgaatcggc caacgcgcgg ggagaggcgg     3600

tttgcgtatt gggcgccagg gtggtttttc ttttcaccag tgagacgggc aacagctgat     3660

tgcccttcac cgcctggccc tgagagagtt gcagcaagcg gtccacgctg gtttgcccca     3720

gcaggcgaaa atcctgtttg atggtggtta acggcgggat ataacatgag ctgtcttcgg     3780

tatcgtcgta tcccactacc gagatatccg caccaacgcg cagcccggac tcggtaatgg     3840

cgcgcattgc gcccagcgcc atctgatcgt tggcaaccag catcgcagtg ggaacgatgc     3900

cctcattcag catttgcatg gtttgttgaa aaccggacat ggcactccag tcgccttccc     3960

gttccgctat cggctgaatt tgattgcgag tgagatattt atgccagcca gccagacgca     4020

gacgcgccga gacagaactt aatgggcccg ctaacagcgc gatttgctgg tgacccaatg     4080

cgaccagatg ctccacgccc agtcgcgtac cgtcttcatg ggagaaaata atactgttga     4140

tgggtgtctg gtcagagaca tcaagaaata acgccggaac attagtgcag gcagcttcca     4200

cagcaatggc atcctggtca tccagcggat agttaatgat cagcccactg acgcgttgcg     4260

cgagaagatt gtgcaccgcc gctttacagg cttcgacgcc gcttcgttct accatcgaca     4320

ccaccacgct ggcacccagt tgatcggcgc gagatttaat cgccgcgaca atttgcgacg     4380

gcgcgtgcag ggccagactg gaggtggcaa cgccaatcag caacgactgt ttgcccgcca     4440

gttgttgtgc cacgcggttg ggaatgtaat tcagctccgc catcgccgct tccacttttt     4500

cccgcgtttt cgcagaaacg tggctggcct ggttcaccac gcgggaaacg gtctgataag     4560

agacaccggc atactctgcg acatcgtata acgttactgg tttcacattc accaccctga     4620

attgactctc ttccgggcgc tatcatgcca taccgcgaaa ggttttgcgc cattcgatgg     4680

tgtccgggat ctcgacgctc tcccttatgc gactcctgca ttaggaagca gcccagtagt     4740

aggttgaggc cgttgagcac cgccgccgca aggaatggtg catgcaagga gatggcgccc     4800

aacagtcccc cggccacggg gcctgccacc atacccacgc cgaaacaagc gctcatgagc     4860

ccgaagtggc gagcccgatc ttccccatcg gtgatgtcgg cgatataggc gccagcaacc     4920

gcacctgtgg cgccggtgat gccggccacg atgcgtccgg cgtagaggat cgagatctcg     4980

atcccgcgaa attaatacga ctcactatag gggaattgtg agcggataac aattcccctc     5040

tagaaataat tttgtttaac tttaagaagg agatatacca tgggcagcag ccatcatcat     5100

catcatcaca gcagcggcct ggtgccgcgc ggcagccata tggaaaacct gtatttccag     5160

gggcccgagg aacccctggt ggtgaaagtc gaggagggcg ataacgctgt cctgcaatgc     5220

cttaagggaa cgtctgacgg ccccacacaa caattaacat ggtctcgcga atcccccttg     5280

aagccctttt tgaaactgtc attaggcttg cccggtcttg ggatccacat gcgtccatta     5340

gcgatttggc ttttcatctt caatgtctcg caacaaatgg gcggtttcta cctttgtcaa     5400

cctggacccc ctagtgaaaa agcgtggcaa cccgggtgga ctgtcaatgt cgaaggatct     5460

ggcgagcttt tccgttggaa cgtaagtgac ttaggtggac tgggctgcgg tcttaaaaat     5520

cgctccagcg agggcccaag tagtccatct ggcaaactga tgtcgccaaa gctttatgtt     5580

tgggcaaaag atcgcccaga aatttgggaa ggtgagccgc cctgcttacc accccgtgat     5640

tctttgaacc aatcacttag ccaggactta actatggcac cagggagtac gctttggttg     5700

agttgcggcg ttcctcctga ttcagtctcc cgcggccctc tgtcttggac gcacgtccat     5760

ccaaagggcc cgaagtccct gttaagcctt gagttgaaag atgaccgccc tgctcgcgat     5820

atgtgggtca tggaaacggg gttgctttta ccgcgtgcca cagcgcaaga tgcgggaaaa     5880

tattactgcc accgcggaaa tttaacgatg tccttccatt tggagatcac cgcccgtccg     5940

gtattgtggc actggctgct gcgcacaggg ggctggaaag ggggatccgg tgggtctgga     6000

ggaagtggcg gaagtggtgg atctggcggt agttccgtga cggtccactc atctgagccg     6060

gaagttcgca ttcctgaaaa caaccccgta aaactgagtt gcgcctattc agggttttca     6120

tcacctcgcg tcgaatggaa attcgatcaa ggtgacacca ctcgcttagt gtgttataac     6180

aacaaaatca cggcgtcata cgaggatcgc gttactttct taccaacagg catcaccttt     6240

aaatctgtaa cacgcgagga tacaggaacc tatacttgta tggtttcgga ggagggtggg     6300

aattcgtacg gcgaggtaaa agtcaaattg attgtgttag tcccgccttc aaagcccacg     6360

gttaatattc cctcgtctgc tacaattggt aaccgcgccg ttcttacatg ctccgaacaa     6420

gatggtagtc cgccctccga atatacatgg ttcaaggacg gcatcgtaat gccaacaaat     6480

ccgaaaagta cacgcgcttt cagcaattcg tcatacgtct taaatcccac caccggcgaa     6540

ttggtcttcg atccactttc agcctctgac actggtgagt actcatgcga ggctcgtaat     6600

ggctatggta cgccaatgac aagtaacgct gtacgcatgg aggcggtcga acgcaacgtt     6660

ggagttgcct gtgagcagaa tcccatctac tgggcgcgct atgcggactg gttattcacg     6720

acacccttac tgctgttgga cttagccctt cttgttgacg ccgatgaggg aactgggtga     6780

tgactcgagc accaccacca ccaccactga gatccggctg ctaacaaagc ccgaaaggaa     6840

gctgagttgg ctgctgccac cgctgagcaa taactagcat aaccccttgg ggcctctaaa     6900

cgggtcttga ggggtttttt gctgaaagga gga                                  6933


<210>  2
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translation product of pET28a CM19XA

<400>  2

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Glu Asn Leu Tyr Phe Gln Gly Pro Glu Glu Pro 
            20                  25                  30          


Leu Val Val Lys Val Glu Glu Gly Asp Asn Ala Val Leu Gln Cys Leu 
        35                  40                  45              


Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu Thr Trp Ser Arg Glu 
    50                  55                  60                  


Ser Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu Gly Leu Pro Gly Leu 
65                  70                  75                  80  


Gly Ile His Met Arg Pro Leu Ala Ile Trp Leu Phe Ile Phe Asn Val 
                85                  90                  95      


Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln Pro Gly Pro Pro Ser 
            100                 105                 110         


Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn Val Glu Gly Ser Gly 
        115                 120                 125             


Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly Gly Leu Gly Cys Gly 
    130                 135                 140                 


Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro Ser Gly Lys Leu 
145                 150                 155                 160 


Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp Arg Pro Glu Ile Trp 
                165                 170                 175     


Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp Ser Leu Asn Gln Ser 
            180                 185                 190         


Leu Ser Gln Asp Leu Thr Met Ala Pro Gly Ser Thr Leu Trp Leu Ser 
        195                 200                 205             


Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly Pro Leu Ser Trp Thr 
    210                 215                 220                 


His Val His Pro Lys Gly Pro Lys Ser Leu Leu Ser Leu Glu Leu Lys 
225                 230                 235                 240 


Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met Glu Thr Gly Leu Leu 
                245                 250                 255     


Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys Tyr Tyr Cys His Arg 
            260                 265                 270         


Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile Thr Ala Arg Pro Val 
        275                 280                 285             


Leu Trp His Trp Leu Leu Arg Thr Gly Gly Trp Lys Gly Gly Ser Gly 
    290                 295                 300                 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Ser Val 
305                 310                 315                 320 


Thr Val His Ser Ser Glu Pro Glu Val Arg Ile Pro Glu Asn Asn Pro 
                325                 330                 335     


Val Lys Leu Ser Cys Ala Tyr Ser Gly Phe Ser Ser Pro Arg Val Glu 
            340                 345                 350         


Trp Lys Phe Asp Gln Gly Asp Thr Thr Arg Leu Val Cys Tyr Asn Asn 
        355                 360                 365             


Lys Ile Thr Ala Ser Tyr Glu Asp Arg Val Thr Phe Leu Pro Thr Gly 
    370                 375                 380                 


Ile Thr Phe Lys Ser Val Thr Arg Glu Asp Thr Gly Thr Tyr Thr Cys 
385                 390                 395                 400 


Met Val Ser Glu Glu Gly Gly Asn Ser Tyr Gly Glu Val Lys Val Lys 
                405                 410                 415     


Leu Ile Val Leu Val Pro Pro Ser Lys Pro Thr Val Asn Ile Pro Ser 
            420                 425                 430         


Ser Ala Thr Ile Gly Asn Arg Ala Val Leu Thr Cys Ser Glu Gln Asp 
        435                 440                 445             


Gly Ser Pro Pro Ser Glu Tyr Thr Trp Phe Lys Asp Gly Ile Val Met 
    450                 455                 460                 


Pro Thr Asn Pro Lys Ser Thr Arg Ala Phe Ser Asn Ser Ser Tyr Val 
465                 470                 475                 480 


Leu Asn Pro Thr Thr Gly Glu Leu Val Phe Asp Pro Leu Ser Ala Ser 
                485                 490                 495     


Asp Thr Gly Glu Tyr Ser Cys Glu Ala Arg Asn Gly Tyr Gly Thr Pro 
            500                 505                 510         


Met Thr Ser Asn Ala Val Arg Met Glu Ala Val Glu Arg Asn Val Gly 
        515                 520                 525             


Val Ala Cys Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Asp Trp 
    530                 535                 540                 


Leu Phe Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp 
545                 550                 555                 560 


Ala Asp Glu Gly Thr Gly 
                565     


<210>  3
<211>  1641
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CM19XA: CD19-JAM A-pHLIP

<400>  3
gaaaacctgt atttccaggg gcccgaggaa cccctggtgg tgaaagtcga ggagggcgat       60

aacgctgtcc tgcaatgcct taagggaacg tctgacggcc ccacacaaca attaacatgg      120

tctcgcgaat cccccttgaa gccctttttg aaactgtcat taggcttgcc cggtcttggg      180

atccacatgc gtccattagc gatttggctt ttcatcttca atgtctcgca acaaatgggc      240

ggtttctacc tttgtcaacc tggaccccct agtgaaaaag cgtggcaacc cgggtggact      300

gtcaatgtcg aaggatctgg cgagcttttc cgttggaacg taagtgactt aggtggactg      360

ggctgcggtc ttaaaaatcg ctccagcgag ggcccaagta gtccatctgg caaactgatg      420

tcgccaaagc tttatgtttg ggcaaaagat cgcccagaaa tttgggaagg tgagccgccc      480

tgcttaccac cccgtgattc tttgaaccaa tcacttagcc aggacttaac tatggcacca      540

gggagtacgc tttggttgag ttgcggcgtt cctcctgatt cagtctcccg cggccctctg      600

tcttggacgc acgtccatcc aaagggcccg aagtccctgt taagccttga gttgaaagat      660

gaccgccctg ctcgcgatat gtgggtcatg gaaacggggt tgcttttacc gcgtgccaca      720

gcgcaagatg cgggaaaata ttactgccac cgcggaaatt taacgatgtc cttccatttg      780

gagatcaccg cccgtccggt attgtggcac tggctgctgc gcacaggggg ctggaaaggg      840

ggatccggtg ggtctggagg aagtggcgga agtggtggat ctggcggtag ttccgtgacg      900

gtccactcat ctgagccgga agttcgcatt cctgaaaaca accccgtaaa actgagttgc      960

gcctattcag ggttttcatc acctcgcgtc gaatggaaat tcgatcaagg tgacaccact     1020

cgcttagtgt gttataacaa caaaatcacg gcgtcatacg aggatcgcgt tactttctta     1080

ccaacaggca tcacctttaa atctgtaaca cgcgaggata caggaaccta tacttgtatg     1140

gtttcggagg agggtgggaa ttcgtacggc gaggtaaaag tcaaattgat tgtgttagtc     1200

ccgccttcaa agcccacggt taatattccc tcgtctgcta caattggtaa ccgcgccgtt     1260

cttacatgct ccgaacaaga tggtagtccg ccctccgaat atacatggtt caaggacggc     1320

atcgtaatgc caacaaatcc gaaaagtaca cgcgctttca gcaattcgtc atacgtctta     1380

aatcccacca ccggcgaatt ggtcttcgat ccactttcag cctctgacac tggtgagtac     1440

tcatgcgagg ctcgtaatgg ctatggtacg ccaatgacaa gtaacgctgt acgcatggag     1500

gcggtcgaac gcaacgttgg agttgcctgt gagcagaatc ccatctactg ggcgcgctat     1560

gcggactggt tattcacgac acccttactg ctgttggact tagcccttct tgttgacgcc     1620

gatgagggaa ctgggtgatg a                                               1641


<210>  4
<211>  545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of CD19-JAM A-pHLIP

<400>  4

Glu Asn Leu Tyr Phe Gln Gly Pro Glu Glu Pro Leu Val Val Lys Val 
1               5                   10                  15      


Glu Glu Gly Asp Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp 
            20                  25                  30          


Gly Pro Thr Gln Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro 
        35                  40                  45              


Phe Leu Lys Leu Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg 
    50                  55                  60                  


Pro Leu Ala Ile Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly 
65                  70                  75                  80  


Gly Phe Tyr Leu Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln 
                85                  90                  95      


Pro Gly Trp Thr Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp 
            100                 105                 110         


Asn Val Ser Asp Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser 
        115                 120                 125             


Ser Glu Gly Pro Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu 
    130                 135                 140                 


Tyr Val Trp Ala Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro 
145                 150                 155                 160 


Cys Leu Pro Pro Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu 
                165                 170                 175     


Thr Met Ala Pro Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro 
            180                 185                 190         


Asp Ser Val Ser Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys 
        195                 200                 205             


Gly Pro Lys Ser Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala 
    210                 215                 220                 


Arg Asp Met Trp Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr 
225                 230                 235                 240 


Ala Gln Asp Ala Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met 
                245                 250                 255     


Ser Phe His Leu Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu 
            260                 265                 270         


Leu Arg Thr Gly Gly Trp Lys Gly Gly Ser Gly Gly Ser Gly Gly Ser 
        275                 280                 285             


Gly Gly Ser Gly Gly Ser Gly Gly Ser Ser Val Thr Val His Ser Ser 
    290                 295                 300                 


Glu Pro Glu Val Arg Ile Pro Glu Asn Asn Pro Val Lys Leu Ser Cys 
305                 310                 315                 320 


Ala Tyr Ser Gly Phe Ser Ser Pro Arg Val Glu Trp Lys Phe Asp Gln 
                325                 330                 335     


Gly Asp Thr Thr Arg Leu Val Cys Tyr Asn Asn Lys Ile Thr Ala Ser 
            340                 345                 350         


Tyr Glu Asp Arg Val Thr Phe Leu Pro Thr Gly Ile Thr Phe Lys Ser 
        355                 360                 365             


Val Thr Arg Glu Asp Thr Gly Thr Tyr Thr Cys Met Val Ser Glu Glu 
    370                 375                 380                 


Gly Gly Asn Ser Tyr Gly Glu Val Lys Val Lys Leu Ile Val Leu Val 
385                 390                 395                 400 


Pro Pro Ser Lys Pro Thr Val Asn Ile Pro Ser Ser Ala Thr Ile Gly 
                405                 410                 415     


Asn Arg Ala Val Leu Thr Cys Ser Glu Gln Asp Gly Ser Pro Pro Ser 
            420                 425                 430         


Glu Tyr Thr Trp Phe Lys Asp Gly Ile Val Met Pro Thr Asn Pro Lys 
        435                 440                 445             


Ser Thr Arg Ala Phe Ser Asn Ser Ser Tyr Val Leu Asn Pro Thr Thr 
    450                 455                 460                 


Gly Glu Leu Val Phe Asp Pro Leu Ser Ala Ser Asp Thr Gly Glu Tyr 
465                 470                 475                 480 


Ser Cys Glu Ala Arg Asn Gly Tyr Gly Thr Pro Met Thr Ser Asn Ala 
                485                 490                 495     


Val Arg Met Glu Ala Val Glu Arg Asn Val Gly Val Ala Cys Glu Gln 
            500                 505                 510         


Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Asp Trp Leu Phe Thr Thr Pro 
        515                 520                 525             


Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Ala Asp Glu Gly Thr 
    530                 535                 540                 


Gly 
545 


<210>  5
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CM19XB: CD19-JAM B-pHLIP

<400>  5
gaaaacctgt atttccaggg gccagaagaa ccgttagtag tgaaagtaga ggaaggtgat       60

aacgctgttc tgcaatgtct taagggtaca tccgatgggc ccactcagca gttaacttgg      120

agtcgtgagt caccccttaa gccctttttg aagctttccc ttggcttacc tggactggga      180

atccacatgc gccctttggc aatctggctg tttattttta acgtctcaca gcaaatgggg      240

ggattctatt tgtgccaacc tgggcccccg agtgagaaag cgtggcaacc aggttggacc      300

gtgaacgttg aaggttcagg tgagttattc cgctggaacg tgtccgacct tggaggctta      360

ggttgtggct taaagaaccg ttcatcagag gggccctcca gccccagtgg taagctgatg      420

agtccaaagc tgtacgtgtg ggctaaagat cgtcccgaaa tctgggaagg ggaaccaccg      480

tgtctgcctc ctcgtgacag tttaaaccag tcgctgtcac aggaccttac catggcccct      540

gggtccacct tatggctgag ttgcggcgtt ccaccggatt cggtttcacg cggccctctg      600

agttggactc acgtccaccc taaggggccg aaaagcttgt tatcgttgga gctgaaagac      660

gaccgcccgg ctcgtgatat gtgggtaatg gagacaggat tacttttgcc tcgcgcaact      720

gcacaagatg cgggtaagta ttactgccac cgtgggaact tgaccatgag cttccacttg      780

gagattaccg cacgcccggt tttatggcac tggttgttac gtaccggtgg ctggaagggt      840

ggatcgggcg gctctggggg gagcggcgga tcaggaggta gcgggggtag tttctccgcg      900

ccgaaagatc agcaagtagt cactgccgta gaatatcagg aggcgattct ggcgtgtaaa      960

acgcctaaaa agaccgtctc gtcacgtctt gagtggaaga aactgggacg ttctgtttcc     1020

tttgtttact atcaacagac gttgcagggt gatttcaaaa atcgtgctga gatgattgat     1080

ttcaacatcc gtattaagaa cgtcactcgc tctgatgcag ggaaataccg ttgcgaagta     1140

agcgcacctt cggaacaggg ccagaattta gaggaagata cggtgacctt ggaggtgttg     1200

gtagctccgg cagtcccgtc ctgcgaagta ccgagttctg ccctgtcggg gactgttgta     1260

gagcttcgtt gccaagacaa ggaagggaat cctgctccgg aatacacctg gttcaaggat     1320

ggcatccgtc ttctggaaaa cccgcgcctt ggtagccaaa gcacaaactc ctcctacacc     1380

atgaatacta agactggtac gctgcagttc aataccgtga gcaagctgga caccggcgaa     1440

tattcttgtg aggcacgcaa cagcgtcggg tatcgtcgtt gccccggtaa acgcatgcaa     1500

gtagatgact tgaacatttc cgcatgcgag cagaatccca tctactgggc gcgttacgcc     1560

gattggttgt tcacgacgcc gttgctgtta cttgatcttg cgttactggt ggatgcagat     1620

gaaggaacag ggtga                                                      1635


<210>  6
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of CD19-JAM B-pHLIP

<400>  6

Glu Asn Leu Tyr Phe Gln Gly Pro Glu Glu Pro Leu Val Val Lys Val 
1               5                   10                  15      


Glu Glu Gly Asp Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp 
            20                  25                  30          


Gly Pro Thr Gln Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro 
        35                  40                  45              


Phe Leu Lys Leu Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg 
    50                  55                  60                  


Pro Leu Ala Ile Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly 
65                  70                  75                  80  


Gly Phe Tyr Leu Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln 
                85                  90                  95      


Pro Gly Trp Thr Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp 
            100                 105                 110         


Asn Val Ser Asp Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser 
        115                 120                 125             


Ser Glu Gly Pro Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu 
    130                 135                 140                 


Tyr Val Trp Ala Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro 
145                 150                 155                 160 


Cys Leu Pro Pro Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu 
                165                 170                 175     


Thr Met Ala Pro Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro 
            180                 185                 190         


Asp Ser Val Ser Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys 
        195                 200                 205             


Gly Pro Lys Ser Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala 
    210                 215                 220                 


Arg Asp Met Trp Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr 
225                 230                 235                 240 


Ala Gln Asp Ala Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met 
                245                 250                 255     


Ser Phe His Leu Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu 
            260                 265                 270         


Leu Arg Thr Gly Gly Trp Lys Gly Gly Ser Gly Gly Ser Gly Gly Ser 
        275                 280                 285             


Gly Gly Ser Gly Gly Ser Gly Gly Ser Phe Ser Ala Pro Lys Asp Gln 
    290                 295                 300                 


Gln Val Val Thr Ala Val Glu Tyr Gln Glu Ala Ile Leu Ala Cys Lys 
305                 310                 315                 320 


Thr Pro Lys Lys Thr Val Ser Ser Arg Leu Glu Trp Lys Lys Leu Gly 
                325                 330                 335     


Arg Ser Val Ser Phe Val Tyr Tyr Gln Gln Thr Leu Gln Gly Asp Phe 
            340                 345                 350         


Lys Asn Arg Ala Glu Met Ile Asp Phe Asn Ile Arg Ile Lys Asn Val 
        355                 360                 365             


Thr Arg Ser Asp Ala Gly Lys Tyr Arg Cys Glu Val Ser Ala Pro Ser 
    370                 375                 380                 


Glu Gln Gly Gln Asn Leu Glu Glu Asp Thr Val Thr Leu Glu Val Leu 
385                 390                 395                 400 


Val Ala Pro Ala Val Pro Ser Cys Glu Val Pro Ser Ser Ala Leu Ser 
                405                 410                 415     


Gly Thr Val Val Glu Leu Arg Cys Gln Asp Lys Glu Gly Asn Pro Ala 
            420                 425                 430         


Pro Glu Tyr Thr Trp Phe Lys Asp Gly Ile Arg Leu Leu Glu Asn Pro 
        435                 440                 445             


Arg Leu Gly Ser Gln Ser Thr Asn Ser Ser Tyr Thr Met Asn Thr Lys 
    450                 455                 460                 


Thr Gly Thr Leu Gln Phe Asn Thr Val Ser Lys Leu Asp Thr Gly Glu 
465                 470                 475                 480 


Tyr Ser Cys Glu Ala Arg Asn Ser Val Gly Tyr Arg Arg Cys Pro Gly 
                485                 490                 495     


Lys Arg Met Gln Val Asp Asp Leu Asn Ile Ser Ala Cys Glu Gln Asn 
            500                 505                 510         


Pro Ile Tyr Trp Ala Arg Tyr Ala Asp Trp Leu Phe Thr Thr Pro Leu 
        515                 520                 525             


Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Ala Asp Glu Gly Thr Gly 
    530                 535                 540                 


<210>  7
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CM19XC: CD19-JAM C-pHLIP

<400>  7
gaaaacctgt atttccaggg gcccgaagaa ccccttgtag ttaaagtaga agagggtgac       60

aatgccgttc ttcagtgttt aaaaggcaca tcagacgggc ccacacagca gttgacatgg      120

agccgtgaat cccccttgaa gccattttta aagctgtcct tagggttacc ggggttaggt      180

atccacatgc gcccccttgc tatctggctt tttatcttta acgtatctca gcagatgggg      240

ggcttctacc tttgccagcc gggtccccct tcagagaaag cctggcagcc gggctggaca      300

gtcaatgtgg aaggcagcgg cgagttgttt cgctggaatg tctcagatct tgggggcttg      360

gggtgtggcc ttaaaaatcg ctcttcggag ggaccctcaa gcccgagtgg aaaacttatg      420

tcgcctaagc tttacgtatg ggctaaggac cgccctgaga tttgggaggg agaaccccct      480

tgtttacctc cccgtgattc gttgaaccaa tctttatccc aggatttaac tatggcgcca      540

ggatcaactt tatggctgag ctgcggggtg ccccctgact cagtgtcccg cgggccttta      600

agttggacgc atgtgcaccc taaggggcca aaatcgctgc tgagtttgga gcttaaggat      660

gatcgcccag cgcgtgatat gtgggtaatg gaaactgggt tgctgttgcc ccgtgcgacc      720

gctcaggatg ccgggaagta ttattgtcac cgcggcaacc ttaccatgtc atttcatttg      780

gaaatcaccg cccgcccagt tttgtggcat tggcttttgc gcactggcgg gtggaaaggc      840

ggttcaggag gcagcggcgg tagcggtggt agcggaggtt caggcgggtc ggtaaatctg      900

aaatcatcga atcgcactcc tgtagttcaa gagtttgaga gcgttgagtt aagctgcatt      960

attacggata gtcagacatc agatcctcgt atcgagtgga aaaagattca ggacgagcaa     1020

actacttacg tcttcttcga caacaaaatt cagggcgact tggctggccg cgcagagatt     1080

ctgggcaaaa ctagccttaa gatctggaac gtcacgcgcc gtgacagtgc attgtaccgc     1140

tgtgaagtgg tggcccgtaa cgaccgcaag gagatcgatg agattgttat tgaattgaca     1200

gttcaggtga agccagtaac cccagtgtgc cgtgtcccaa aggccgtacc ggttggtaaa     1260

atggcaactt tgcattgcca ggagtcagaa ggtcatccgc gcccacacta ttcgtggtat     1320

cgtaatgacg tacccttacc cactgattca cgcgctaatc ctcgcttccg caactcaagt     1380

ttccacttaa attccgaaac tggtacatta gtattcaccg ctgtccacaa ggacgactcg     1440

ggtcaatatt actgtattgc atctaatgac gccggatctg cacgttgcga agagcaggag     1500

atggaagtct acgatttaaa tgcttgtgaa caaaatccaa tttattgggc gcgctatgcc     1560

gattggttgt ttacaacgcc gttactgtta ttggatttag ctttacttgt agacgccgat     1620

gagggaacag gatga                                                      1635


<210>  8
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of CD19-JAM C-pHLIP

<400>  8

Glu Asn Leu Tyr Phe Gln Gly Pro Glu Glu Pro Leu Val Val Lys Val 
1               5                   10                  15      


Glu Glu Gly Asp Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp 
            20                  25                  30          


Gly Pro Thr Gln Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro 
        35                  40                  45              


Phe Leu Lys Leu Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg 
    50                  55                  60                  


Pro Leu Ala Ile Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly 
65                  70                  75                  80  


Gly Phe Tyr Leu Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln 
                85                  90                  95      


Pro Gly Trp Thr Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp 
            100                 105                 110         


Asn Val Ser Asp Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser 
        115                 120                 125             


Ser Glu Gly Pro Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu 
    130                 135                 140                 


Tyr Val Trp Ala Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro 
145                 150                 155                 160 


Cys Leu Pro Pro Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu 
                165                 170                 175     


Thr Met Ala Pro Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro 
            180                 185                 190         


Asp Ser Val Ser Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys 
        195                 200                 205             


Gly Pro Lys Ser Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala 
    210                 215                 220                 


Arg Asp Met Trp Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr 
225                 230                 235                 240 


Ala Gln Asp Ala Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met 
                245                 250                 255     


Ser Phe His Leu Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu 
            260                 265                 270         


Leu Arg Thr Gly Gly Trp Lys Gly Gly Ser Gly Gly Ser Gly Gly Ser 
        275                 280                 285             


Gly Gly Ser Gly Gly Ser Gly Gly Ser Val Asn Leu Lys Ser Ser Asn 
    290                 295                 300                 


Arg Thr Pro Val Val Gln Glu Phe Glu Ser Val Glu Leu Ser Cys Ile 
305                 310                 315                 320 


Ile Thr Asp Ser Gln Thr Ser Asp Pro Arg Ile Glu Trp Lys Lys Ile 
                325                 330                 335     


Gln Asp Glu Gln Thr Thr Tyr Val Phe Phe Asp Asn Lys Ile Gln Gly 
            340                 345                 350         


Asp Leu Ala Gly Arg Ala Glu Ile Leu Gly Lys Thr Ser Leu Lys Ile 
        355                 360                 365             


Trp Asn Val Thr Arg Arg Asp Ser Ala Leu Tyr Arg Cys Glu Val Val 
    370                 375                 380                 


Ala Arg Asn Asp Arg Lys Glu Ile Asp Glu Ile Val Ile Glu Leu Thr 
385                 390                 395                 400 


Val Gln Val Lys Pro Val Thr Pro Val Cys Arg Val Pro Lys Ala Val 
                405                 410                 415     


Pro Val Gly Lys Met Ala Thr Leu His Cys Gln Glu Ser Glu Gly His 
            420                 425                 430         


Pro Arg Pro His Tyr Ser Trp Tyr Arg Asn Asp Val Pro Leu Pro Thr 
        435                 440                 445             


Asp Ser Arg Ala Asn Pro Arg Phe Arg Asn Ser Ser Phe His Leu Asn 
    450                 455                 460                 


Ser Glu Thr Gly Thr Leu Val Phe Thr Ala Val His Lys Asp Asp Ser 
465                 470                 475                 480 


Gly Gln Tyr Tyr Cys Ile Ala Ser Asn Asp Ala Gly Ser Ala Arg Cys 
                485                 490                 495     


Glu Glu Gln Glu Met Glu Val Tyr Asp Leu Asn Ala Cys Glu Gln Asn 
            500                 505                 510         


Pro Ile Tyr Trp Ala Arg Tyr Ala Asp Trp Leu Phe Thr Thr Pro Leu 
        515                 520                 525             


Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Ala Asp Glu Gly Thr Gly 
    530                 535                 540                 


<210>  9
<211>  1803
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CM19X4: CD19-JAM4-pHLIP

<400>  9
gaaaacctgt atttccaggg gccagaggaa ccattagtgg ttaaggtaga ggaaggcgat       60

aatgcagtct tacagtgtct taaaggaact tcagacggcc cgacccaaca gctgacttgg      120

tctcgtgaaa gcccgttaaa acccttcctt aagctgagcc tgggtttgcc tggtttagga      180

attcacatgc gtccccttgc gatctggctg tttattttta atgtgtctca gcaaatgggc      240

gggttttact tgtgtcagcc agggccccca tcggagaagg cttggcaacc cggctggacc      300

gtgaacgtcg agggtagtgg ggaacttttc cgctggaacg tttccgattt aggcggtctt      360

ggctgcggcc ttaagaatcg ttcttcggaa gggccgagtt ccccgtctgg aaagctgatg      420

tcacctaagt tatatgtttg ggccaaggat cgtccagaga tttgggaggg cgagcccccc      480

tgtctgccgc cacgtgacag cctgaaccag agtttgagcc aggatcttac gatggcccct      540

gggtcgactc tttggttatc gtgcggggtt ccacccgact cggtttcacg cggcccctta      600

tcgtggaccc acgtacatcc aaaggggccg aaatcgttat tgagcttgga attaaaagat      660

gaccgtcctg ctcgcgacat gtgggtaatg gagaccgggc tgctgttacc gcgtgcgact      720

gctcaagatg ctggcaaata ctattgccac cgtggaaact tgactatgag ctttcacctg      780

gaaatcacag ctcgccccgt tttatggcac tggttgttac gcacgggcgg ttggaagggg      840

ggctcaggag gtagcggcgg gtcaggtgga tcgggaggtt ccggcgggag tatgggacag      900

aaagaacgtt caacagccga tacactgcca gatttggagg agtggaagag cgcagctggc      960

cttcgttggt ggcagacagc cgttgtggat ggttctgggt cagggaatga ggtgattgag     1020

ggaccgcaga atgcacgtgt attgaagggt tcccaggctc gctttaactg caccgtgagc     1080

cagggctgga agctgattat gtgggcactg agcgacatgg tggttctttc agttcgccca     1140

atggagccta tcatcacgaa tgaccgcttc actagtcagc gctatgacca agggggaaac     1200

ttcactagcg agatgatcat ccacaatgtc gagccctctg atagcggaaa tatccgttgt     1260

tcactgcaga attcgcgtct tcacgggtct gcgtacctta ccgtccaggt catgggagag     1320

ttatttatcc caagcgtaaa tttggtggta gctgagaatg agccctgtga ggtgacttgt     1380

ctgccctctc attggacccg cttgcccgac atttcatggg aattaggctt gttggtctca     1440

cactcgtctt attactttgt accggaaccc tctgatttgc aatcagcagt ctcaattctg     1500

gctctgactc ctcaatcaaa cggtacgctt acgtgtgttg cgacatggaa aagtctgaaa     1560

gcgcgtaaat ccgcgacagt caatcttact gttattcgct gtccacaaga cacgggtgga     1620

gggattaata tcccaggagt attgtcctct ttaccgtcgc tggggttcag tcttccgaca     1680

tgggggaagg catgcgaaca aaatccaatt tattgggcgc gttatgctga ttggttattt     1740

acaaccccac tgttactgct tgatttggca ctgcttgttg acgctgacga gggcaccggc     1800

tga                                                                   1803


<210>  10
<211>  600
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of CD19-JAM4-pHLIP

<400>  10

Glu Asn Leu Tyr Phe Gln Gly Pro Glu Glu Pro Leu Val Val Lys Val 
1               5                   10                  15      


Glu Glu Gly Asp Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp 
            20                  25                  30          


Gly Pro Thr Gln Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro 
        35                  40                  45              


Phe Leu Lys Leu Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg 
    50                  55                  60                  


Pro Leu Ala Ile Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly 
65                  70                  75                  80  


Gly Phe Tyr Leu Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln 
                85                  90                  95      


Pro Gly Trp Thr Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp 
            100                 105                 110         


Asn Val Ser Asp Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser 
        115                 120                 125             


Ser Glu Gly Pro Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu 
    130                 135                 140                 


Tyr Val Trp Ala Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro 
145                 150                 155                 160 


Cys Leu Pro Pro Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu 
                165                 170                 175     


Thr Met Ala Pro Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro 
            180                 185                 190         


Asp Ser Val Ser Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys 
        195                 200                 205             


Gly Pro Lys Ser Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala 
    210                 215                 220                 


Arg Asp Met Trp Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr 
225                 230                 235                 240 


Ala Gln Asp Ala Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met 
                245                 250                 255     


Ser Phe His Leu Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu 
            260                 265                 270         


Leu Arg Thr Gly Gly Trp Lys Gly Gly Ser Gly Gly Ser Gly Gly Ser 
        275                 280                 285             


Gly Gly Ser Gly Gly Ser Gly Gly Ser Met Gly Gln Lys Glu Arg Ser 
    290                 295                 300                 


Thr Ala Asp Thr Leu Pro Asp Leu Glu Glu Trp Lys Ser Ala Ala Gly 
305                 310                 315                 320 


Leu Arg Trp Trp Gln Thr Ala Val Val Asp Gly Ser Gly Ser Gly Asn 
                325                 330                 335     


Glu Val Ile Glu Gly Pro Gln Asn Ala Arg Val Leu Lys Gly Ser Gln 
            340                 345                 350         


Ala Arg Phe Asn Cys Thr Val Ser Gln Gly Trp Lys Leu Ile Met Trp 
        355                 360                 365             


Ala Leu Ser Asp Met Val Val Leu Ser Val Arg Pro Met Glu Pro Ile 
    370                 375                 380                 


Ile Thr Asn Asp Arg Phe Thr Ser Gln Arg Tyr Asp Gln Gly Gly Asn 
385                 390                 395                 400 


Phe Thr Ser Glu Met Ile Ile His Asn Val Glu Pro Ser Asp Ser Gly 
                405                 410                 415     


Asn Ile Arg Cys Ser Leu Gln Asn Ser Arg Leu His Gly Ser Ala Tyr 
            420                 425                 430         


Leu Thr Val Gln Val Met Gly Glu Leu Phe Ile Pro Ser Val Asn Leu 
        435                 440                 445             


Val Val Ala Glu Asn Glu Pro Cys Glu Val Thr Cys Leu Pro Ser His 
    450                 455                 460                 


Trp Thr Arg Leu Pro Asp Ile Ser Trp Glu Leu Gly Leu Leu Val Ser 
465                 470                 475                 480 


His Ser Ser Tyr Tyr Phe Val Pro Glu Pro Ser Asp Leu Gln Ser Ala 
                485                 490                 495     


Val Ser Ile Leu Ala Leu Thr Pro Gln Ser Asn Gly Thr Leu Thr Cys 
            500                 505                 510         


Val Ala Thr Trp Lys Ser Leu Lys Ala Arg Lys Ser Ala Thr Val Asn 
        515                 520                 525             


Leu Thr Val Ile Arg Cys Pro Gln Asp Thr Gly Gly Gly Ile Asn Ile 
    530                 535                 540                 


Pro Gly Val Leu Ser Ser Leu Pro Ser Leu Gly Phe Ser Leu Pro Thr 
545                 550                 555                 560 


Trp Gly Lys Ala Cys Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala 
                565                 570                 575     


Asp Trp Leu Phe Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu 
            580                 585                 590         


Val Asp Ala Asp Glu Gly Thr Gly 
        595                 600 


