﻿                         序列表

<110>  深圳先进技术研究院

<120>  一种基于共振能量转移的全遗传编码NAD+蛋白探针及其制备方法和应用

<160>  13

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  716
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  1
Met Val Ser Lys Gly Glu Ala Val Ile Lys Glu Phe Met Arg Phe Lys 
1               5                   10                  15      
Val His Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 
            20                  25                  30          
Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 
        35                  40                  45              
Val Thr Lys Gly Gly Pro Leu Pro Phe Ser Trp Asp Ile Leu Ser Pro 
    50                  55                  60                  
Gln Phe Met Tyr Gly Ser Arg Ala Phe Thr Lys His Pro Ala Asp Ile 
65                  70                  75                  80  
Pro Asp Tyr Tyr Lys Gln Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 
                85                  90                  95      
Val Met Asn Phe Glu Asp Gly Gly Ala Val Thr Val Thr Gln Asp Thr 
            100                 105                 110         
Ser Leu Glu Asp Gly Thr Leu Ile Tyr Lys Val Lys Leu Arg Gly Thr 
        115                 120                 125             
Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 
    130                 135                 140                 
Glu Ala Ser Thr Glu Arg Leu Tyr Pro Glu Asp Gly Val Leu Lys Gly 
145                 150                 155                 160 
Asp Ile Lys Met Ala Leu Arg Leu Lys Asp Gly Gly Arg Tyr Leu Ala 
                165                 170                 175     
Asp Phe Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Met Pro Gly 
            180                 185                 190         
Ala Tyr Asn Val Asp Arg Lys Leu Asp Ile Thr Ser His Asn Glu Asp 
        195                 200                 205             
Tyr Thr Val Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His Ser Thr 
    210                 215                 220                 
Leu Thr Leu Thr Ala Ala Thr Thr Arg Ala Gln Glu Leu Arg Lys Gln 
225                 230                 235                 240 
Leu Asn Gln Tyr Ser His Glu Tyr Tyr Val Lys Asp Gln Pro Ser Val 
                245                 250                 255     
Glu Asp Tyr Val Tyr Asp Arg Leu Tyr Lys Glu Leu Val Asp Ile Glu 
            260                 265                 270         
Thr Glu Phe Pro Asp Leu Ile Thr Pro Asp Ser Pro Thr Gln Asn Val 
        275                 280                 285             
Gly Gly Lys Val Leu Ser Gly Phe Glu Lys Ala Pro His Asp Ile Pro 
    290                 295                 300                 
Met Tyr Ser Leu Asn Asp Gly Phe Ser Lys Glu Asp Ile Phe Ala Phe 
305                 310                 315                 320 
Asp Glu Arg Val Arg Lys Ala Ile Gly Lys Pro Val Ala Tyr Cys Cys 
                325                 330                 335     
Glu Leu Leu Ile Asp Gly Leu Ala Ile Ser Leu Arg Tyr Glu Asn Gly 
            340                 345                 350         
Val Phe Val Arg Gly Ala Thr Arg Gly Asp Gly Thr Val Gly Glu Asn 
        355                 360                 365             
Ile Thr Glu Asn Leu Arg Thr Val Arg Ser Val Pro Met Asp Leu Thr 
    370                 375                 380                 
Glu Pro Ile Ser Val Glu Val Arg Gly Glu Cys Tyr Met Pro Lys Gln 
385                 390                 395                 400 
Ser Phe Val Ala Leu Asn Glu Glu Arg Glu Glu Asn Gly Gln Asp Ile 
                405                 410                 415     
Phe Ala Asn Pro Arg Asn Ala Ala Ala Gly Ser Leu Arg Gln Leu Asp 
            420                 425                 430         
Thr Lys Ile Val Ala Lys Arg Asn Leu Asn Thr Phe Leu Tyr Thr Val 
        435                 440                 445             
Ala Asp Phe Gly Pro Met Lys Ala Lys Thr Gln Phe Glu Ala Leu Glu 
    450                 455                 460                 
Glu Leu Ser Ala Ile Gly Phe Arg Thr Asn Pro Glu Arg Gln Leu Cys 
465                 470                 475                 480 
Gln Ser Ile Asp Glu Val Trp Ala Tyr Ile Glu Glu Tyr His Glu Lys 
                485                 490                 495     
Arg Ser Thr Leu Pro Tyr Glu Ile Asn Gly Ile Val Ile Lys Val Asn 
            500                 505                 510         
Glu Phe Ala Leu Gln Asp Glu Leu Gly Phe Thr Val Lys Ala Pro Arg 
        515                 520                 525             
Trp Ala Ile Ala Tyr Lys Phe Pro Gly Asp Gln Met Gly Gln Ile Glu 
    530                 535                 540                 
Lys Ile Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val 
545                 550                 555                 560 
Ile Leu His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met 
                565                 570                 575     
Ile Asp Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly 
            580                 585                 590         
Lys Lys Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile 
        595                 600                 605             
Asp Glu Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr 
    610                 615                 620                 
Ile Asn Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly 
625                 630                 635                 640 
Gly Thr Gly Gly Ser Gly Gly Thr Gly Gly Ser Met Val Phe Thr Leu 
                645                 650                 655     
Glu Asp Phe Val Gly Asp Trp Arg Gln Thr Ala Gly Tyr Asn Leu Asp 
            660                 665                 670         
Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu Phe Gln Asn Leu Gly 
        675                 680                 685             
Val Ser Val Thr Pro Ile Gln Arg Ile Val Leu Ser Gly Glu Asn Gly 
    690                 695                 700                 
Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr Glu 
705                 710                 715     

<210>  2
<211>  224
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  2
Met Val Ser Lys Gly Glu Ala Val Ile Lys Glu Phe Met Arg Phe Lys 
1               5                   10                  15      
Val His Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 
            20                  25                  30          
Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 
        35                  40                  45              
Val Thr Lys Gly Gly Pro Leu Pro Phe Ser Trp Asp Ile Leu Ser Pro 
    50                  55                  60                  
Gln Phe Met Tyr Gly Ser Arg Ala Phe Thr Lys His Pro Ala Asp Ile 
65                  70                  75                  80  
Pro Asp Tyr Tyr Lys Gln Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 
                85                  90                  95      
Val Met Asn Phe Glu Asp Gly Gly Ala Val Thr Val Thr Gln Asp Thr 
            100                 105                 110         
Ser Leu Glu Asp Gly Thr Leu Ile Tyr Lys Val Lys Leu Arg Gly Thr 
        115                 120                 125             
Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 
    130                 135                 140                 
Glu Ala Ser Thr Glu Arg Leu Tyr Pro Glu Asp Gly Val Leu Lys Gly 
145                 150                 155                 160 
Asp Ile Lys Met Ala Leu Arg Leu Lys Asp Gly Gly Arg Tyr Leu Ala 
                165                 170                 175     
Asp Phe Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Met Pro Gly 
            180                 185                 190         
Ala Tyr Asn Val Asp Arg Lys Leu Asp Ile Thr Ser His Asn Glu Asp 
        195                 200                 205             
Tyr Thr Val Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His Ser Thr 
    210                 215                 220                 

<210>  3
<211>  312
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  3
Leu Thr Leu Thr Ala Ala Thr Thr Arg Ala Gln Glu Leu Arg Lys Gln 
1               5                   10                  15      
Leu Asn Gln Tyr Ser His Glu Tyr Tyr Val Lys Asp Gln Pro Ser Val 
            20                  25                  30          
Glu Asp Tyr Val Tyr Asp Arg Leu Tyr Lys Glu Leu Val Asp Ile Glu 
        35                  40                  45              
Thr Glu Phe Pro Asp Leu Ile Thr Pro Asp Ser Pro Thr Gln Asn Val 
    50                  55                  60                  
Gly Gly Lys Val Leu Ser Gly Phe Glu Lys Ala Pro His Asp Ile Pro 
65                  70                  75                  80  
Met Tyr Ser Leu Asn Asp Gly Phe Ser Lys Glu Asp Ile Phe Ala Phe 
                85                  90                  95      
Asp Glu Arg Val Arg Lys Ala Ile Gly Lys Pro Val Ala Tyr Cys Cys 
            100                 105                 110         
Glu Leu Leu Ile Asp Gly Leu Ala Ile Ser Leu Arg Tyr Glu Asn Gly 
        115                 120                 125             
Val Phe Val Arg Gly Ala Thr Arg Gly Asp Gly Thr Val Gly Glu Asn 
    130                 135                 140                 
Ile Thr Glu Asn Leu Arg Thr Val Arg Ser Val Pro Met Asp Leu Thr 
145                 150                 155                 160 
Glu Pro Ile Ser Val Glu Val Arg Gly Glu Cys Tyr Met Pro Lys Gln 
                165                 170                 175     
Ser Phe Val Ala Leu Asn Glu Glu Arg Glu Glu Asn Gly Gln Asp Ile 
            180                 185                 190         
Phe Ala Asn Pro Arg Asn Ala Ala Ala Gly Ser Leu Arg Gln Leu Asp 
        195                 200                 205             
Thr Lys Ile Val Ala Lys Arg Asn Leu Asn Thr Phe Leu Tyr Thr Val 
    210                 215                 220                 
Ala Asp Phe Gly Pro Met Lys Ala Lys Thr Gln Phe Glu Ala Leu Glu 
225                 230                 235                 240 
Glu Leu Ser Ala Ile Gly Phe Arg Thr Asn Pro Glu Arg Gln Leu Cys 
                245                 250                 255     
Gln Ser Ile Asp Glu Val Trp Ala Tyr Ile Glu Glu Tyr His Glu Lys 
            260                 265                 270         
Arg Ser Thr Leu Pro Tyr Glu Ile Asn Gly Ile Val Ile Lys Val Asn 
        275                 280                 285             
Glu Phe Ala Leu Gln Asp Glu Leu Gly Phe Thr Val Lys Ala Pro Arg 
    290                 295                 300                 
Trp Ala Ile Ala Tyr Lys Phe Pro 
305                 310         

<210>  4
<211>  180
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  4
Gly Asp Gln Met Gly Gln Ile Glu Lys Ile Phe Lys Val Val Tyr Pro 
1               5                   10                  15      
Val Asp Asp His His Phe Lys Val Ile Leu His Tyr Gly Thr Leu Val 
            20                  25                  30          
Ile Asp Gly Val Thr Pro Asn Met Ile Asp Tyr Phe Gly Arg Pro Tyr 
        35                  40                  45              
Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr Val Thr Gly Thr 
    50                  55                  60                  
Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile Asn Pro Asp 
65                  70                  75                  80  
Gly Ser Leu Leu Phe Arg Val Thr Ile Asn Gly Val Thr Gly Trp Arg 
                85                  90                  95      
Leu Cys Glu Arg Ile Leu Ala Gly Gly Thr Gly Gly Ser Gly Gly Thr 
            100                 105                 110         
Gly Gly Ser Met Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg 
        115                 120                 125             
Gln Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val 
    130                 135                 140                 
Ser Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg 
145                 150                 155                 160 
Ile Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile 
                165                 170                 175     
Ile Pro Tyr Glu 
            180 

<210>  5
<211>  716
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  5
Met Val Ser Lys Gly Glu Ala Val Ile Lys Glu Phe Met Arg Phe Lys 
1               5                   10                  15      
Val His Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 
            20                  25                  30          
Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 
        35                  40                  45              
Val Thr Lys Gly Gly Pro Leu Pro Phe Ser Trp Asp Ile Leu Ser Pro 
    50                  55                  60                  
Gln Phe Met Tyr Gly Ser Arg Ala Phe Thr Lys His Pro Ala Asp Ile 
65                  70                  75                  80  
Pro Asp Tyr Tyr Lys Gln Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 
                85                  90                  95      
Val Met Asn Phe Glu Asp Gly Gly Ala Val Thr Val Thr Gln Asp Thr 
            100                 105                 110         
Ser Leu Glu Asp Gly Thr Leu Ile Tyr Lys Val Lys Leu Arg Gly Thr 
        115                 120                 125             
Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 
    130                 135                 140                 
Glu Ala Ser Thr Glu Arg Leu Tyr Pro Glu Asp Gly Val Leu Lys Gly 
145                 150                 155                 160 
Asp Ile Lys Met Ala Leu Arg Leu Lys Asp Gly Gly Arg Tyr Leu Ala 
                165                 170                 175     
Asp Phe Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Met Pro Gly 
            180                 185                 190         
Ala Tyr Asn Val Asp Arg Lys Leu Asp Ile Thr Ser His Asn Glu Asp 
        195                 200                 205             
Tyr Thr Val Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His Ser Thr 
    210                 215                 220                 
Leu Thr Leu Thr Ala Ala Thr Thr Arg Ala Gln Glu Leu Arg Lys Gln 
225                 230                 235                 240 
Leu Asn Gln Tyr Ser His Glu Tyr Tyr Val Lys Asp Gln Pro Ser Val 
                245                 250                 255     
Glu Asp Tyr Val Tyr Asp Arg Leu Tyr Lys Glu Leu Val Asp Ile Glu 
            260                 265                 270         
Thr Glu Phe Pro Asp Leu Ile Thr Pro Asp Ser Pro Thr Gln Asn Val 
        275                 280                 285             
Gly Gly Lys Val Leu Ser Gly Phe Glu Lys Ala Pro His Asp Ile Pro 
    290                 295                 300                 
Met Tyr Ser Leu Asn Asp Gly Phe Ser Lys Glu Asp Ile Phe Ala Phe 
305                 310                 315                 320 
Asp Glu Arg Val Arg Lys Ala Ile Gly Lys Pro Val Ala Tyr Cys Cys 
                325                 330                 335     
Glu Leu Leu Ile Asp Gly Leu Ala Ile Ser Leu Arg Tyr Glu Asn Gly 
            340                 345                 350         
Val Phe Val Arg Gly Ala Thr Arg Gly Asp Gly Thr Val Gly Glu Asn 
        355                 360                 365             
Ile Thr Glu Asn Leu Arg Thr Val Arg Ser Val Pro Met Pro Leu Thr 
    370                 375                 380                 
Glu Pro Ile Ser Val Glu Val Arg Gly Glu Cys Tyr Met Pro Lys Gln 
385                 390                 395                 400 
Ser Phe Val Ala Leu Asn Glu Glu Arg Glu Glu Asn Gly Gln Asp Ile 
                405                 410                 415     
Phe Ala Asn Pro Arg Asn Ala Ala Ala Gly Ser Leu Arg Gln Leu Asp 
            420                 425                 430         
Thr Lys Ile Val Ala Lys Arg Asn Leu Asn Thr Phe Leu Tyr Thr Val 
        435                 440                 445             
Ala Asp Phe Gly Pro Met Lys Ala Lys Thr Gln Phe Glu Ala Leu Glu 
    450                 455                 460                 
Glu Leu Ser Ala Ile Gly Phe Arg Thr Asn Pro Glu Arg Gln Leu Cys 
465                 470                 475                 480 
Gln Ser Ile Asp Glu Val Trp Ala Tyr Ile Glu Glu Tyr His Glu Lys 
                485                 490                 495     
Arg Ser Thr Leu Pro Tyr Glu Ile Asn Gly Ile Val Ile Lys Val Asn 
            500                 505                 510         
Glu Phe Ala Leu Gln Asp Glu Leu Gly Phe Thr Val Lys Ala Pro Arg 
        515                 520                 525             
Trp Ala Ile Ala Tyr Lys Phe Pro Gly Asp Gln Met Gly Gln Ile Glu 
    530                 535                 540                 
Lys Ile Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val 
545                 550                 555                 560 
Ile Leu His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met 
                565                 570                 575     
Ile Asp Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly 
            580                 585                 590         
Lys Lys Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile 
        595                 600                 605             
Asp Glu Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr 
    610                 615                 620                 
Ile Asn Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly 
625                 630                 635                 640 
Gly Thr Gly Gly Ser Gly Gly Thr Gly Gly Ser Met Val Phe Thr Leu 
                645                 650                 655     
Glu Asp Phe Val Gly Asp Trp Arg Gln Thr Ala Gly Tyr Asn Leu Asp 
            660                 665                 670         
Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu Phe Gln Asn Leu Gly 
        675                 680                 685             
Val Ser Val Thr Pro Ile Gln Arg Ile Val Leu Ser Gly Glu Asn Gly 
    690                 695                 700                 
Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr Glu 
705                 710                 715     

<210>  6
<211>  296
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  6
Leu Asn Gln Tyr Ser His Glu Tyr Tyr Val Lys Asp Gln Pro Ser Val 
1               5                   10                  15      
Glu Asp Tyr Val Tyr Asp Arg Leu Tyr Lys Glu Leu Val Asp Ile Glu 
            20                  25                  30          
Thr Glu Phe Pro Asp Leu Ile Thr Pro Asp Ser Pro Thr Gln Asn Val 
        35                  40                  45              
Gly Gly Lys Val Leu Ser Gly Phe Glu Lys Ala Pro His Asp Ile Pro 
    50                  55                  60                  
Met Tyr Ser Leu Asn Asp Gly Phe Ser Lys Glu Asp Ile Phe Ala Phe 
65                  70                  75                  80  
Asp Glu Arg Val Arg Lys Ala Ile Gly Lys Pro Val Ala Tyr Cys Cys 
                85                  90                  95      
Glu Leu Leu Ile Asp Gly Leu Ala Ile Ser Leu Arg Tyr Glu Asn Gly 
            100                 105                 110         
Val Phe Val Arg Gly Ala Thr Arg Gly Asp Gly Thr Val Gly Glu Asn 
        115                 120                 125             
Ile Thr Glu Asn Leu Arg Thr Val Arg Ser Val Pro Met Pro Leu Thr 
    130                 135                 140                 
Glu Pro Ile Ser Val Glu Val Arg Gly Glu Cys Tyr Met Pro Lys Gln 
145                 150                 155                 160 
Ser Phe Val Ala Leu Asn Glu Glu Arg Glu Glu Asn Gly Gln Asp Ile 
                165                 170                 175     
Phe Ala Asn Pro Arg Asn Ala Ala Ala Gly Ser Leu Arg Gln Leu Asp 
            180                 185                 190         
Thr Lys Ile Val Ala Lys Arg Asn Leu Asn Thr Phe Leu Tyr Thr Val 
        195                 200                 205             
Ala Asp Phe Gly Pro Met Lys Ala Lys Thr Gln Phe Glu Ala Leu Glu 
    210                 215                 220                 
Glu Leu Ser Ala Ile Gly Phe Arg Thr Asn Pro Glu Arg Gln Leu Cys 
225                 230                 235                 240 
Gln Ser Ile Asp Glu Val Trp Ala Tyr Ile Glu Glu Tyr His Glu Lys 
                245                 250                 255     
Arg Ser Thr Leu Pro Tyr Glu Ile Asn Gly Ile Val Ile Lys Val Asn 
            260                 265                 270         
Glu Phe Ala Leu Gln Asp Glu Leu Gly Phe Thr Val Lys Ala Pro Arg 
        275                 280                 285             
Trp Ala Ile Ala Tyr Lys Phe Pro 
    290                 295     

<210>  7
<211>  716
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  7
Met Val Ser Lys Gly Glu Ala Val Ile Lys Glu Phe Met Arg Phe Lys 
1               5                   10                  15      
Val His Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 
            20                  25                  30          
Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 
        35                  40                  45              
Val Thr Lys Gly Gly Pro Leu Pro Phe Ser Trp Asp Ile Leu Ser Pro 
    50                  55                  60                  
Gln Phe Met Tyr Gly Ser Arg Ala Phe Thr Lys His Pro Ala Asp Ile 
65                  70                  75                  80  
Pro Asp Tyr Tyr Lys Gln Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 
                85                  90                  95      
Val Met Asn Phe Glu Asp Gly Gly Ala Val Thr Val Thr Gln Asp Thr 
            100                 105                 110         
Ser Leu Glu Asp Gly Thr Leu Ile Tyr Lys Val Lys Leu Arg Gly Thr 
        115                 120                 125             
Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 
    130                 135                 140                 
Glu Ala Ser Thr Glu Arg Leu Tyr Pro Glu Asp Gly Val Leu Lys Gly 
145                 150                 155                 160 
Asp Ile Lys Met Ala Leu Arg Leu Lys Asp Gly Gly Arg Tyr Leu Ala 
                165                 170                 175     
Asp Phe Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Met Pro Gly 
            180                 185                 190         
Ala Tyr Asn Val Asp Arg Lys Leu Asp Ile Thr Ser His Asn Glu Asp 
        195                 200                 205             
Tyr Thr Val Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His Ser Thr 
    210                 215                 220                 
Leu Thr Leu Thr Ala Ala Thr Thr Arg Ala Gln Glu Leu Arg Lys Gln 
225                 230                 235                 240 
Leu Asn Gln Tyr Ser His Glu Tyr Tyr Val Lys Asp Gln Pro Ser Val 
                245                 250                 255     
Glu Asp Tyr Val Tyr Asp Arg Leu Tyr Lys Glu Leu Val Asp Ile Glu 
            260                 265                 270         
Thr Glu Phe Pro Asp Leu Ile Thr Pro Asp Ser Pro Thr Gln Asn Val 
        275                 280                 285             
Gly Gly Lys Val Leu Ser Gly Phe Glu Lys Ala Pro His Asp Ile Pro 
    290                 295                 300                 
Met Tyr Ser Leu Asn Asp Gly Phe Ser Lys Glu Asp Ile Phe Ala Phe 
305                 310                 315                 320 
Asp Glu Arg Val Arg Lys Ala Ile Gly Lys Pro Val Ala Tyr Cys Cys 
                325                 330                 335     
Glu Leu Leu Ile Asp Gly Leu Ala Ile Ser Leu Arg Tyr Glu Asn Gly 
            340                 345                 350         
Val Phe Val Arg Gly Ala Thr Arg Gly Asp Gly Thr Val Gly Glu Asn 
        355                 360                 365             
Ile Thr Glu Asn Leu Arg Thr Val Arg Ser Val Pro Met Asp Leu Thr 
    370                 375                 380                 
Glu Pro Ile Ser Val Glu Val Arg Gly Glu Cys Tyr Met Pro Lys Gln 
385                 390                 395                 400 
Ser Phe Val Ala Leu Asn Glu Glu Arg Glu Glu Asn Gly Gln Asp Ile 
                405                 410                 415     
Phe Ala Asn Pro Arg Asn Ala Ala Ala Gly Ser Leu Arg Gln Leu Asp 
            420                 425                 430         
Thr Lys Ile Val Ala Lys Arg Asn Leu Asn Thr Phe Leu Tyr Thr Val 
        435                 440                 445             
Ala Asp Phe Gly Pro Met Lys Ala Lys Thr Gln Phe Glu Ala Leu Glu 
    450                 455                 460                 
Glu Leu Ser Ala Ile Gly Phe Arg Thr Asn Pro Glu Arg Gln Leu Cys 
465                 470                 475                 480 
Gln Ser Ile Asp Glu Val Trp Ala Tyr Ile Glu Glu Tyr His Glu Lys 
                485                 490                 495     
Arg Ser Thr Leu Pro Tyr Glu Ile Asn Gly Ile Val Ile Lys Val Asn 
            500                 505                 510         
Glu Phe Ala Leu Gln Asp Glu Leu Gly Phe Thr Val Lys Ala Pro Arg 
        515                 520                 525             
Trp Ala Ile Ala Tyr Lys Phe Pro Val Asp Gln Met Gly Gln Ile Glu 
    530                 535                 540                 
Lys Ile Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val 
545                 550                 555                 560 
Ile Leu His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met 
                565                 570                 575     
Ile Asp Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly 
            580                 585                 590         
Lys Lys Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile 
        595                 600                 605             
Asp Glu Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr 
    610                 615                 620                 
Ile Asn Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly 
625                 630                 635                 640 
Gly Thr Gly Gly Ser Gly Gly Thr Gly Gly Ser Met Val Phe Thr Leu 
                645                 650                 655     
Glu Asp Phe Val Gly Asp Trp Arg Gln Thr Ala Gly Tyr Asn Leu Asp 
            660                 665                 670         
Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu Phe Gln Asn Leu Gly 
        675                 680                 685             
Val Ser Val Thr Pro Ile Gln Arg Ile Val Leu Ser Gly Glu Asn Gly 
    690                 695                 700                 
Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr Glu 
705                 710                 715     

<210>  8
<211>  180
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  8
Val Asp Gln Met Gly Gln Ile Glu Lys Ile Phe Lys Val Val Tyr Pro 
1               5                   10                  15      
Val Asp Asp His His Phe Lys Val Ile Leu His Tyr Gly Thr Leu Val 
            20                  25                  30          
Ile Asp Gly Val Thr Pro Asn Met Ile Asp Tyr Phe Gly Arg Pro Tyr 
        35                  40                  45              
Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr Val Thr Gly Thr 
    50                  55                  60                  
Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile Asn Pro Asp 
65                  70                  75                  80  
Gly Ser Leu Leu Phe Arg Val Thr Ile Asn Gly Val Thr Gly Trp Arg 
                85                  90                  95      
Leu Cys Glu Arg Ile Leu Ala Gly Gly Thr Gly Gly Ser Gly Gly Thr 
            100                 105                 110         
Gly Gly Ser Met Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg 
        115                 120                 125             
Gln Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val 
    130                 135                 140                 
Ser Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg 
145                 150                 155                 160 
Ile Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile 
                165                 170                 175     
Ile Pro Tyr Glu 
            180 

<210>  9
<211>  711
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  9
Met Ala Ser Leu Pro Ala Thr His Glu Leu His Ile Phe Gly Ser Ile 
1               5                   10                  15      
Asn Gly Val Asp Phe Asp Met Val Gly Gln Gly Thr Gly Asn Pro Asn 
            20                  25                  30          
Asp Gly Tyr Glu Glu Leu Asn Leu Lys Ser Thr Lys Gly Asp Leu Gln 
        35                  40                  45              
Phe Ser Pro Trp Ile Leu Val Pro His Ile Gly Tyr Gly Phe His Gln 
    50                  55                  60                  
Tyr Leu Pro Tyr Pro Asp Gly Met Ser Pro Phe Gln Ala Ala Met Val 
65                  70                  75                  80  
Asp Gly Ser Gly Tyr Gln Val His Arg Thr Met Gln Phe Glu Asp Gly 
                85                  90                  95      
Ala Ser Leu Thr Val Asn Tyr Arg Tyr Thr Tyr Glu Gly Ser His Ile 
            100                 105                 110         
Lys Gly Glu Ala Gln Val Lys Gly Thr Gly Phe Pro Ala Asp Gly Pro 
        115                 120                 125             
Val Met Thr Asn Ser Leu Thr Ala Ala Asp Trp Cys Arg Ser Lys Lys 
    130                 135                 140                 
Thr Tyr Pro Asn Asp Lys Thr Ile Ile Ser Thr Phe Lys Trp Ser Tyr 
145                 150                 155                 160 
Thr Thr Gly Asn Gly Lys Arg Tyr Arg Ser Thr Ala Arg Thr Thr Tyr 
                165                 170                 175     
Thr Phe Ala Lys Pro Met Ala Ala Asn Tyr Leu Lys Asn Gln Pro Met 
            180                 185                 190         
Tyr Val Phe Arg Lys Thr Glu Leu Lys His Ser Lys Thr Glu Leu Asn 
        195                 200                 205             
Phe Lys Glu Trp Gln Lys Ala Phe Thr Asp Lys Leu Thr Leu Thr Ala 
    210                 215                 220                 
Ala Thr Thr Arg Ala Gln Glu Leu Arg Lys Gln Leu Asn Gln Tyr Ser 
225                 230                 235                 240 
His Glu Tyr Tyr Val Lys Asp Gln Pro Ser Val Glu Asp Tyr Val Tyr 
                245                 250                 255     
Asp Arg Leu Tyr Lys Glu Leu Val Asp Ile Glu Thr Glu Phe Pro Asp 
            260                 265                 270         
Leu Ile Thr Pro Asp Ser Pro Thr Gln Asn Val Gly Gly Lys Val Leu 
        275                 280                 285             
Ser Gly Phe Glu Lys Ala Pro His Asp Ile Pro Met Tyr Ser Leu Asn 
    290                 295                 300                 
Asp Gly Phe Ser Lys Glu Asp Ile Phe Ala Phe Asp Glu Arg Val Arg 
305                 310                 315                 320 
Lys Ala Ile Gly Lys Pro Val Ala Tyr Cys Cys Glu Leu Leu Ile Asp 
                325                 330                 335     
Gly Leu Ala Ile Ser Leu Arg Tyr Glu Asn Gly Val Phe Val Arg Gly 
            340                 345                 350         
Ala Thr Arg Gly Asp Gly Thr Val Gly Glu Asn Ile Thr Glu Asn Leu 
        355                 360                 365             
Arg Thr Val Arg Ser Val Pro Met Asp Leu Thr Glu Pro Ile Ser Val 
    370                 375                 380                 
Glu Val Arg Gly Glu Cys Tyr Met Pro Lys Gln Ser Phe Val Ala Leu 
385                 390                 395                 400 
Asn Glu Glu Arg Glu Glu Asn Gly Gln Asp Ile Phe Ala Asn Pro Arg 
                405                 410                 415     
Asn Ala Ala Ala Gly Ser Leu Arg Gln Leu Asp Thr Lys Ile Val Ala 
            420                 425                 430         
Lys Arg Asn Leu Asn Thr Phe Leu Tyr Thr Val Ala Asp Phe Gly Pro 
        435                 440                 445             
Met Lys Ala Lys Thr Gln Phe Glu Ala Leu Glu Glu Leu Ser Ala Ile 
    450                 455                 460                 
Gly Phe Arg Thr Asn Pro Glu Arg Gln Leu Cys Gln Ser Ile Asp Glu 
465                 470                 475                 480 
Val Trp Ala Tyr Ile Glu Glu Tyr His Glu Lys Arg Ser Thr Leu Pro 
                485                 490                 495     
Tyr Glu Ile Asn Gly Ile Val Ile Lys Val Asn Glu Phe Ala Leu Gln 
            500                 505                 510         
Asp Glu Leu Gly Phe Thr Val Lys Ala Pro Arg Trp Ala Ile Ala Tyr 
        515                 520                 525             
Lys Phe Pro Val Asp Gln Met Gly Gln Ile Glu Lys Ile Phe Lys Val 
    530                 535                 540                 
Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu His Tyr Gly 
545                 550                 555                 560 
Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp Tyr Phe Gly 
                565                 570                 575     
Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr Val 
            580                 585                 590         
Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile 
        595                 600                 605             
Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn Gly Val Thr 
    610                 615                 620                 
Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Thr Gly Gly Ser 
625                 630                 635                 640 
Gly Gly Thr Gly Gly Ser Met Val Phe Thr Leu Glu Asp Phe Val Gly 
                645                 650                 655     
Asp Trp Arg Gln Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln 
            660                 665                 670         
Gly Gly Val Ser Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro 
        675                 680                 685             
Ile Gln Arg Ile Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile 
    690                 695                 700                 
His Val Ile Ile Pro Tyr Glu 
705                 710     

<210>  10
<211>  219
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  10
Met Ala Ser Leu Pro Ala Thr His Glu Leu His Ile Phe Gly Ser Ile 
1               5                   10                  15      
Asn Gly Val Asp Phe Asp Met Val Gly Gln Gly Thr Gly Asn Pro Asn 
            20                  25                  30          
Asp Gly Tyr Glu Glu Leu Asn Leu Lys Ser Thr Lys Gly Asp Leu Gln 
        35                  40                  45              
Phe Ser Pro Trp Ile Leu Val Pro His Ile Gly Tyr Gly Phe His Gln 
    50                  55                  60                  
Tyr Leu Pro Tyr Pro Asp Gly Met Ser Pro Phe Gln Ala Ala Met Val 
65                  70                  75                  80  
Asp Gly Ser Gly Tyr Gln Val His Arg Thr Met Gln Phe Glu Asp Gly 
                85                  90                  95      
Ala Ser Leu Thr Val Asn Tyr Arg Tyr Thr Tyr Glu Gly Ser His Ile 
            100                 105                 110         
Lys Gly Glu Ala Gln Val Lys Gly Thr Gly Phe Pro Ala Asp Gly Pro 
        115                 120                 125             
Val Met Thr Asn Ser Leu Thr Ala Ala Asp Trp Cys Arg Ser Lys Lys 
    130                 135                 140                 
Thr Tyr Pro Asn Asp Lys Thr Ile Ile Ser Thr Phe Lys Trp Ser Tyr 
145                 150                 155                 160 
Thr Thr Gly Asn Gly Lys Arg Tyr Arg Ser Thr Ala Arg Thr Thr Tyr 
                165                 170                 175     
Thr Phe Ala Lys Pro Met Ala Ala Asn Tyr Leu Lys Asn Gln Pro Met 
            180                 185                 190         
Tyr Val Phe Arg Lys Thr Glu Leu Lys His Ser Lys Thr Glu Leu Asn 
        195                 200                 205             
Phe Lys Glu Trp Gln Lys Ala Phe Thr Asp Lys 
    210                 215                 

<210>  11
<211>  760
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  11
Met Val Ser Lys Gly Glu Ala Val Ile Lys Glu Phe Met Arg Phe Lys 
1               5                   10                  15      
Val His Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 
            20                  25                  30          
Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 
        35                  40                  45              
Val Thr Lys Gly Gly Pro Leu Pro Phe Ser Trp Asp Ile Leu Ser Pro 
    50                  55                  60                  
Gln Phe Met Tyr Gly Ser Arg Ala Phe Thr Lys His Pro Ala Asp Ile 
65                  70                  75                  80  
Pro Asp Tyr Tyr Lys Gln Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 
                85                  90                  95      
Val Met Asn Phe Glu Asp Gly Gly Ala Val Thr Val Thr Gln Asp Thr 
            100                 105                 110         
Ser Leu Glu Asp Gly Thr Leu Ile Tyr Lys Val Lys Leu Arg Gly Thr 
        115                 120                 125             
Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 
    130                 135                 140                 
Glu Ala Ser Thr Glu Arg Leu Tyr Pro Glu Asp Gly Val Leu Lys Gly 
145                 150                 155                 160 
Asp Ile Lys Met Ala Leu Arg Leu Lys Asp Gly Gly Arg Tyr Leu Ala 
                165                 170                 175     
Asp Phe Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Met Pro Gly 
            180                 185                 190         
Ala Tyr Asn Val Asp Arg Lys Leu Asp Ile Thr Ser His Asn Glu Asp 
        195                 200                 205             
Tyr Thr Val Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His Leu Thr 
    210                 215                 220                 
Leu Thr Leu Thr Ala Ala Thr Thr Arg Ala Gln Glu Leu Arg Lys Gln 
225                 230                 235                 240 
Leu Asn Gln Tyr Ser His Glu Tyr Tyr Val Lys Asp Gln Pro Ser Val 
                245                 250                 255     
Glu Asp Tyr Val Tyr Asp Arg Leu Tyr Lys Glu Leu Val Asp Ile Glu 
            260                 265                 270         
Thr Glu Phe Pro Asp Leu Ile Thr Pro Asp Ser Pro Thr Gln Asn Val 
        275                 280                 285             
Gly Gly Lys Val Leu Ser Gly Phe Glu Lys Ala Pro His Asp Ile Pro 
    290                 295                 300                 
Met Tyr Ser Leu Asn Asp Gly Phe Ser Lys Glu Asp Ile Phe Ala Phe 
305                 310                 315                 320 
Asp Glu Arg Val Arg Lys Ala Ile Gly Lys Pro Val Ala Tyr Cys Cys 
                325                 330                 335     
Glu Leu Leu Ile Asp Gly Leu Ala Ile Ser Leu Arg Tyr Glu Asn Gly 
            340                 345                 350         
Val Phe Val Arg Gly Ala Thr Arg Gly Asp Gly Thr Val Gly Glu Asn 
        355                 360                 365             
Ile Thr Glu Asn Leu Arg Thr Val Arg Ser Val Pro Met Asp Leu Thr 
    370                 375                 380                 
Glu Pro Ile Ser Val Glu Val Arg Gly Glu Cys Tyr Met Pro Lys Gln 
385                 390                 395                 400 
Ser Phe Val Ala Leu Asn Glu Glu Arg Glu Glu Asn Gly Gln Asp Ile 
                405                 410                 415     
Phe Ala Asn Pro Arg Asn Ala Ala Ala Gly Ser Leu Arg Gln Leu Asp 
            420                 425                 430         
Thr Lys Ile Val Ala Lys Arg Asn Leu Asn Thr Phe Leu Tyr Thr Val 
        435                 440                 445             
Ala Asp Phe Gly Pro Met Lys Ala Lys Thr Gln Phe Glu Ala Leu Glu 
    450                 455                 460                 
Glu Leu Ser Ala Ile Gly Phe Arg Thr Asn Pro Glu Arg Gln Leu Cys 
465                 470                 475                 480 
Gln Ser Ile Asp Glu Val Trp Ala Tyr Ile Glu Glu Tyr His Glu Lys 
                485                 490                 495     
Arg Ser Thr Leu Pro Tyr Glu Ile Asn Gly Ile Val Ile Lys Val Asn 
            500                 505                 510         
Glu Phe Ala Leu Gln Asp Glu Leu Gly Phe Thr Val Lys Ala Pro Arg 
        515                 520                 525             
Trp Ala Ile Ala Tyr Lys Phe Pro Pro Pro Ala Thr His Glu Leu His 
    530                 535                 540                 
Ile Phe Gly Ser Ile Asn Gly Val Asp Phe Asp Met Val Gly Gln Gly 
545                 550                 555                 560 
Thr Gly Asn Pro Asn Asp Gly Tyr Glu Glu Leu Asn Leu Lys Ser Thr 
                565                 570                 575     
Lys Gly Asp Leu Gln Phe Ser Pro Trp Ile Leu Val Pro His Ile Gly 
            580                 585                 590         
Tyr Gly Phe His Gln Tyr Leu Pro Tyr Pro Asp Gly Met Ser Pro Phe 
        595                 600                 605             
Gln Ala Ala Met Val Asp Gly Ser Gly Tyr Gln Val His Arg Thr Met 
    610                 615                 620                 
Gln Phe Glu Asp Gly Ala Ser Leu Thr Val Asn Tyr Arg Tyr Thr Tyr 
625                 630                 635                 640 
Glu Gly Ser His Ile Lys Gly Glu Ala Gln Val Lys Gly Thr Gly Phe 
                645                 650                 655     
Pro Ala Asp Gly Pro Val Met Thr Asn Ser Leu Thr Ala Ala Asp Trp 
            660                 665                 670         
Cys Arg Ser Lys Lys Thr Tyr Pro Asn Asp Lys Thr Ile Ile Ser Thr 
        675                 680                 685             
Phe Lys Trp Ser Tyr Thr Thr Gly Asn Gly Lys Arg Tyr Arg Ser Thr 
    690                 695                 700                 
Ala Arg Thr Thr Tyr Thr Phe Ala Lys Pro Met Ala Ala Asn Tyr Leu 
705                 710                 715                 720 
Lys Asn Gln Pro Met Tyr Val Phe Arg Lys Thr Glu Leu Lys His Ser 
                725                 730                 735     
Lys Thr Glu Leu Asn Phe Lys Glu Trp Gln Lys Ala Phe Thr Asp Val 
            740                 745                 750         
Met Gly Met Asp Glu Leu Tyr Lys 
        755                 760 

<210>  12
<211>  224
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  12
Met Val Ser Lys Gly Glu Ala Val Ile Lys Glu Phe Met Arg Phe Lys 
1               5                   10                  15      
Val His Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 
            20                  25                  30          
Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 
        35                  40                  45              
Val Thr Lys Gly Gly Pro Leu Pro Phe Ser Trp Asp Ile Leu Ser Pro 
    50                  55                  60                  
Gln Phe Met Tyr Gly Ser Arg Ala Phe Thr Lys His Pro Ala Asp Ile 
65                  70                  75                  80  
Pro Asp Tyr Tyr Lys Gln Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 
                85                  90                  95      
Val Met Asn Phe Glu Asp Gly Gly Ala Val Thr Val Thr Gln Asp Thr 
            100                 105                 110         
Ser Leu Glu Asp Gly Thr Leu Ile Tyr Lys Val Lys Leu Arg Gly Thr 
        115                 120                 125             
Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 
    130                 135                 140                 
Glu Ala Ser Thr Glu Arg Leu Tyr Pro Glu Asp Gly Val Leu Lys Gly 
145                 150                 155                 160 
Asp Ile Lys Met Ala Leu Arg Leu Lys Asp Gly Gly Arg Tyr Leu Ala 
                165                 170                 175     
Asp Phe Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Met Pro Gly 
            180                 185                 190         
Ala Tyr Asn Val Asp Arg Lys Leu Asp Ile Thr Ser His Asn Glu Asp 
        195                 200                 205             
Tyr Thr Val Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His Leu Thr 
    210                 215                 220                 

<210>  13
<211>  224
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  13
Pro Pro Ala Thr His Glu Leu His Ile Phe Gly Ser Ile Asn Gly Val 
1               5                   10                  15      
Asp Phe Asp Met Val Gly Gln Gly Thr Gly Asn Pro Asn Asp Gly Tyr 
            20                  25                  30          
Glu Glu Leu Asn Leu Lys Ser Thr Lys Gly Asp Leu Gln Phe Ser Pro 
        35                  40                  45              
Trp Ile Leu Val Pro His Ile Gly Tyr Gly Phe His Gln Tyr Leu Pro 
    50                  55                  60                  
Tyr Pro Asp Gly Met Ser Pro Phe Gln Ala Ala Met Val Asp Gly Ser 
65                  70                  75                  80  
Gly Tyr Gln Val His Arg Thr Met Gln Phe Glu Asp Gly Ala Ser Leu 
                85                  90                  95      
Thr Val Asn Tyr Arg Tyr Thr Tyr Glu Gly Ser His Ile Lys Gly Glu 
            100                 105                 110         
Ala Gln Val Lys Gly Thr Gly Phe Pro Ala Asp Gly Pro Val Met Thr 
        115                 120                 125             
Asn Ser Leu Thr Ala Ala Asp Trp Cys Arg Ser Lys Lys Thr Tyr Pro 
    130                 135                 140                 
Asn Asp Lys Thr Ile Ile Ser Thr Phe Lys Trp Ser Tyr Thr Thr Gly 
145                 150                 155                 160 
Asn Gly Lys Arg Tyr Arg Ser Thr Ala Arg Thr Thr Tyr Thr Phe Ala 
                165                 170                 175     
Lys Pro Met Ala Ala Asn Tyr Leu Lys Asn Gln Pro Met Tyr Val Phe 
            180                 185                 190         
Arg Lys Thr Glu Leu Lys His Ser Lys Thr Glu Leu Asn Phe Lys Glu 
        195                 200                 205             
Trp Gln Lys Ala Phe Thr Asp Val Met Gly Met Asp Glu Leu Tyr Lys 
    210                 215                 220                 

