                         SEQUENCE LISTING

<110>  ӢƼ޹˾
 
<120>  һټ״ټ嵰סƱӦ

<130>  2021

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  2295
<212>  DNA
<213>  ˹

<400>  1
atgaggccgg cggacttgct gcagctggtg ctgctgctcg acctgcccag ggacctgggc       60

ggaatggggt gttcgtctcc accctgcgag tgccatcagg aggaggactt cagagtcacc      120

tgcaaggata ttcaacgcat ccccagctta ccgcccagta cgcagactct gaagcttatt      180

gagactcacc tgagaactat tccaagtcat gcattttcta atctgcccaa tatttccaga      240

atctacgtat ctatagatgt gactctgcag cagctggaat cacactcctt ctacaatttg      300

agtaaagtga ctcacataga aattcggaat accaggaact taacttacat agaccctgat      360

gccctcaaag agctccccct cctaaagttc cttggcattt tcaacactgg acttaaaatg      420

ttccctgacc tgaccaaagt ttattccact gatatattct ttatacttga aattacagac      480

aacccttaca tgacgtcaat ccctgtgaat gcttttcagg gactatgcaa tgaaaccttg      540

acactgaagc tgtacaacaa tggctttact tcagtccaag gatatgcttt caatgggaca      600

aagctggatg ctgtttacct aaacaagaat aaatacctga cagttattga caaagatgca      660

tttggaggag tatacagtgg accaagcttg ctggacgtgt ctcaaaccag tgtcactgcc      720

cttccatcca aaggcctgga gcacctgaag gaactgatag caagaaacac ctggactctt      780

aagaaacttc cactttcctt gagtttcctt cacctcacac gggctgacct ttcttaccca      840

agccactgct gtgcttttaa gaatcagaag aaaatcagag gaatccttga gtccttgatg      900

tgtaatgaga gcagtatgca gagcttgcgc cagagaaaat ctgtgaatgc cttgaatagc      960

cccctccacc aggaatatga agagaatctg ggtgacagca ttgttgggta caaggaaaag     1020

tccaagttcc aggatactca taacaacgct cattattacg tcttctttga agaacaagag     1080

gatgagatca ttggttttgg ccaggagctc aaaaaccccc aggaagagac tctacaagct     1140

tttgacagcc attatgacta caccatatgt ggggacagtg aagacatggt gtgtaccccc     1200

aagtccgatg agttcaaccc gtgtgaagac ataatgggct acaagttcct gagaattgtg     1260

gtgtggttcg ttagtctgct ggctctcctg ggcaatgtct ttgtcctgct tattctcctc     1320

accagccact acaaactgaa cgtcccccgc tttctcatgt gcaacctggc ctttgcggat     1380

ttctgcatgg ggatgtacct gctcctcatc gcctctgtag acctctacac tcactctgag     1440

tactacaacc atgccatcga ctggcagaca ggccctgggt gcaacacggc tggtttcttc     1500

actgtctttg caagcgagtt atcggtgtat acgctgacgg tcatcaccct ggagcgctgg     1560

tatgccatca ccttcgccat gcgcctggac cggaagatcc gcctcaggca cgcatgtgcc     1620

atcatggttg ggggctgggt ttgctgcttc cttctcgccc tgcttccttt ggtgggaata     1680

agtagctatg ccaaagtcag tatctgcctg cccatggaca ccgagacccc tcttgctctg     1740

gcatatattg tttttgttct gacgctcaac atagttgcct tcgtcatcgt ctgctgctgt     1800

tatgtgaaga tctacatcac agtccgaaat ccgcagtaca acccagggga caaagatacc     1860

aaaattgcca agaggatggc tgtgttgatc ttcaccgact tcatatgcat ggccccaatc     1920

tcattctatg ctctgtcagc aattctgaac aagcctctca tcactgttag caactccaaa     1980

atcttgctgg tactcttcta tccacttaac tcctgtgcca atccattcct ctatgctatt     2040

ttcaccaagg ccttccagag ggatgtgttc atcctactca gcaagtttgg catctgtaaa     2100

cgccaggctc aggcataccg ggggcagagg gttcctccaa agaacagcac tgatattcag     2160

gttcaaaagg ttacccacga gatgaggcag ggtctccaca acatggaaga tgtctatgaa     2220

ctgattgaaa actcccatct aaccccaaag aagcaaggcc aaatctcaga agagtatatg     2280

caaacggttt tgtaa                                                      2295


<210>  2
<211>  681
<212>  DNA
<213>  ˹

<400>  2
gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgttagtc       60

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      240

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      300

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa      360

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggacga gctgaccaag      420

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag      480

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      540

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg      600

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      660

ctctccctgt ctccgggtaa a                                                681


<210>  3
<211>  48
<212>  DNA
<213>  ˹

<400>  3
tctgcctttg cggcggatct tggatccatg ggctgcagca gtccgccg                    48


<210>  4
<211>  42
<212>  DNA
<213>  ˹

<400>  4
gatattatgg gttataaatt tgcaattttt accaaagcct tt                          42


<210>  5
<211>  48
<212>  DNA
<213>  ˹

<400>  5
gaatatatgc agaccgttct ggaattcgac aaaactcaca catgccca                    48


<210>  6
<211>  33
<212>  DNA
<213>  ˹

<400>  6
aaatttataa cccataatat cttcacacgg att                                    33


<210>  7
<211>  30
<212>  DNA
<213>  ˹

<400>  7
gaattccaga acggtctgca tatattcttc                                        30


<210>  8
<211>  57
<212>  DNA
<213>  ˹

<400>  8
gtcccaggaa aggatcagat ctgcagcggc cgcttattta cccggagaca gggagag          57


<210>  9
<211>  1185
<212>  DNA
<213>  ˹

<400>  9
atgggctgca gcagtccgcc gtgtgaatgt catcaggaag aagattttcg tgtgacctgt       60

aaagatattc agcgtattcc gagcctgccg ccgagcaccc agaccttaaa actgattgaa      120

acccatctgc gtaccattcc gagtcatgca ttttctaatc tgccgaatat tagccgcatc      180

tatgttagca ttgatgttac cctgcagcag ctggaaagcc atagctttta taatctgagc      240

aaagtgaccc atattgaaat tcgcaatacc cgtaatctga cctatattga tccggatgca      300

ctgaaagaac tgccgctgct gaaatttctg ggcattttta ataccggtct gaaaatgttt      360

ccggatctga ccaaagttta tagtaccgat attttcttta tcctggaaat taccgataac      420

ccgtatatga ccagcattcc ggtgaatgcc tttcagggtc tgtgcaatga aaccctgacc      480

ctgaaactgt ataataatgg ttttaccagt gtgcagggct atgcctttaa tggcaccaaa      540

ctggatgccg tgtatctgaa taagaataag tatctgaccg tgattgataa agatgccttt      600

ggcggcgtgt atagcggtcc gagtctgctg gatgttagtc agaccagtgt taccgcactg      660

ccgagcaaag gtctggaaca tctgaaagaa ttaattgcac gtaatacctg gaccctgaaa      720

aaactgccgc tgagcctgag ctttctgcat ctgacccgtg ccgatctgag ttatccgagc      780

cattgttgtg cctttaaaaa tcagaaaaag atccgtggta tcctggaaag tctgatgtgc      840

aatgaaagca gcatgcagag cctgcgtcag cgcaaaagcg tgaatgcact gaatagcccg      900

ctgcatcagg aatatgaaga aaatctgggc gatagtattg tgggctataa agaaaaaagt      960

aagttccagg atacccataa taatgcccat tattatgttt tcttcgagga acaggaagat     1020

gaaattattg gttttggtca ggaactgaaa aatccgcagg aagaaaccct gcaggccttt     1080

gatagccatt atgattatac catttgcggc gatagtgaag atatggtgtg caccccgaaa     1140

agtgatgagt ttaatccgtg tgaagatatt atgggttata aattt                     1185


<210>  10
<211>  258
<212>  DNA
<213>  ˹

<400>  10
gcaattttta ccaaagcctt tcagcgtgat gtttttattc tgctgagtaa atttggtatc       60

tgtaaacgcc aggcccaggc atatcgtggc cagcgcgttc cgccgaaaaa tagcaccgat      120

attcaggtgc agaaagttac ccatgaaatg cgtcagggtc tgcataatat ggaagatgtg      180

tatgaactga ttgaaaatag tcatctgacc ccgaaaaaac agggccagat tagcgaagaa      240

tatatgcaga ccgttctg                                                    258


<210>  11
<211>  764
<212>  PRT
<213>  ˹

<400>  11

Met Arg Pro Ala Asp Leu Leu Gln Leu Val Leu Leu Leu Asp Leu Pro 
1               5                   10                  15      


Arg Asp Leu Gly Gly Met Gly Cys Ser Ser Pro Pro Cys Glu Cys His 
            20                  25                  30          


Gln Glu Glu Asp Phe Arg Val Thr Cys Lys Asp Ile Gln Arg Ile Pro 
        35                  40                  45              


Ser Leu Pro Pro Ser Thr Gln Thr Leu Lys Leu Ile Glu Thr His Leu 
    50                  55                  60                  


Arg Thr Ile Pro Ser His Ala Phe Ser Asn Leu Pro Asn Ile Ser Arg 
65                  70                  75                  80  


Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu Ser His Ser 
                85                  90                  95      


Phe Tyr Asn Leu Ser Lys Val Thr His Ile Glu Ile Arg Asn Thr Arg 
            100                 105                 110         


Asn Leu Thr Tyr Ile Asp Pro Asp Ala Leu Lys Glu Leu Pro Leu Leu 
        115                 120                 125             


Lys Phe Leu Gly Ile Phe Asn Thr Gly Leu Lys Met Phe Pro Asp Leu 
    130                 135                 140                 


Thr Lys Val Tyr Ser Thr Asp Ile Phe Phe Ile Leu Glu Ile Thr Asp 
145                 150                 155                 160 


Asn Pro Tyr Met Thr Ser Ile Pro Val Asn Ala Phe Gln Gly Leu Cys 
                165                 170                 175     


Asn Glu Thr Leu Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Val 
            180                 185                 190         


Gln Gly Tyr Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu Asn 
        195                 200                 205             


Lys Asn Lys Tyr Leu Thr Val Ile Asp Lys Asp Ala Phe Gly Gly Val 
    210                 215                 220                 


Tyr Ser Gly Pro Ser Leu Leu Asp Val Ser Gln Thr Ser Val Thr Ala 
225                 230                 235                 240 


Leu Pro Ser Lys Gly Leu Glu His Leu Lys Glu Leu Ile Ala Arg Asn 
                245                 250                 255     


Thr Trp Thr Leu Lys Lys Leu Pro Leu Ser Leu Ser Phe Leu His Leu 
            260                 265                 270         


Thr Arg Ala Asp Leu Ser Tyr Pro Ser His Cys Cys Ala Phe Lys Asn 
        275                 280                 285             


Gln Lys Lys Ile Arg Gly Ile Leu Glu Ser Leu Met Cys Asn Glu Ser 
    290                 295                 300                 


Ser Met Gln Ser Leu Arg Gln Arg Lys Ser Val Asn Ala Leu Asn Ser 
305                 310                 315                 320 


Pro Leu His Gln Glu Tyr Glu Glu Asn Leu Gly Asp Ser Ile Val Gly 
                325                 330                 335     


Tyr Lys Glu Lys Ser Lys Phe Gln Asp Thr His Asn Asn Ala His Tyr 
            340                 345                 350         


Tyr Val Phe Phe Glu Glu Gln Glu Asp Glu Ile Ile Gly Phe Gly Gln 
        355                 360                 365             


Glu Leu Lys Asn Pro Gln Glu Glu Thr Leu Gln Ala Phe Asp Ser His 
    370                 375                 380                 


Tyr Asp Tyr Thr Ile Cys Gly Asp Ser Glu Asp Met Val Cys Thr Pro 
385                 390                 395                 400 


Lys Ser Asp Glu Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr Lys Phe 
                405                 410                 415     


Leu Arg Ile Val Val Trp Phe Val Ser Leu Leu Ala Leu Leu Gly Asn 
            420                 425                 430         


Val Phe Val Leu Leu Ile Leu Leu Thr Ser His Tyr Lys Leu Asn Val 
        435                 440                 445             


Pro Arg Phe Leu Met Cys Asn Leu Ala Phe Ala Asp Phe Cys Met Gly 
    450                 455                 460                 


Met Tyr Leu Leu Leu Ile Ala Ser Val Asp Leu Tyr Thr His Ser Glu 
465                 470                 475                 480 


Tyr Tyr Asn His Ala Ile Asp Trp Gln Thr Gly Pro Gly Cys Asn Thr 
                485                 490                 495     


Ala Gly Phe Phe Thr Val Phe Ala Ser Glu Leu Ser Val Tyr Thr Leu 
            500                 505                 510         


Thr Val Ile Thr Leu Glu Arg Trp Tyr Ala Ile Thr Phe Ala Met Arg 
        515                 520                 525             


Leu Asp Arg Lys Ile Arg Leu Arg His Ala Cys Ala Ile Met Val Gly 
    530                 535                 540                 


Gly Trp Val Cys Cys Phe Leu Leu Ala Leu Leu Pro Leu Val Gly Ile 
545                 550                 555                 560 


Ser Ser Tyr Ala Lys Val Ser Ile Cys Leu Pro Met Asp Thr Glu Thr 
                565                 570                 575     


Pro Leu Ala Leu Ala Tyr Ile Val Phe Val Leu Thr Leu Asn Ile Val 
            580                 585                 590         


Ala Phe Val Ile Val Cys Cys Cys Tyr Val Lys Ile Tyr Ile Thr Val 
        595                 600                 605             


Arg Asn Pro Gln Tyr Asn Pro Gly Asp Lys Asp Thr Lys Ile Ala Lys 
    610                 615                 620                 


Arg Met Ala Val Leu Ile Phe Thr Asp Phe Ile Cys Met Ala Pro Ile 
625                 630                 635                 640 


Ser Phe Tyr Ala Leu Ser Ala Ile Leu Asn Lys Pro Leu Ile Thr Val 
                645                 650                 655     


Ser Asn Ser Lys Ile Leu Leu Val Leu Phe Tyr Pro Leu Asn Ser Cys 
            660                 665                 670         


Ala Asn Pro Phe Leu Tyr Ala Ile Phe Thr Lys Ala Phe Gln Arg Asp 
        675                 680                 685             


Val Phe Ile Leu Leu Ser Lys Phe Gly Ile Cys Lys Arg Gln Ala Gln 
    690                 695                 700                 


Ala Tyr Arg Gly Gln Arg Val Pro Pro Lys Asn Ser Thr Asp Ile Gln 
705                 710                 715                 720 


Val Gln Lys Val Thr His Glu Met Arg Gln Gly Leu His Asn Met Glu 
                725                 730                 735     


Asp Val Tyr Glu Leu Ile Glu Asn Ser His Leu Thr Pro Lys Lys Gln 
            740                 745                 750         


Gly Gln Ile Ser Glu Glu Tyr Met Gln Thr Val Leu 
        755                 760                 


<210>  12
<211>  395
<212>  PRT
<213>  ˹

<400>  12

Met Gly Cys Ser Ser Pro Pro Cys Glu Cys His Gln Glu Glu Asp Phe 
1               5                   10                  15      


Arg Val Thr Cys Lys Asp Ile Gln Arg Ile Pro Ser Leu Pro Pro Ser 
            20                  25                  30          


Thr Gln Thr Leu Lys Leu Ile Glu Thr His Leu Arg Thr Ile Pro Ser 
        35                  40                  45              


His Ala Phe Ser Asn Leu Pro Asn Ile Ser Arg Ile Tyr Val Ser Ile 
    50                  55                  60                  


Asp Val Thr Leu Gln Gln Leu Glu Ser His Ser Phe Tyr Asn Leu Ser 
65                  70                  75                  80  


Lys Val Thr His Ile Glu Ile Arg Asn Thr Arg Asn Leu Thr Tyr Ile 
                85                  90                  95      


Asp Pro Asp Ala Leu Lys Glu Leu Pro Leu Leu Lys Phe Leu Gly Ile 
            100                 105                 110         


Phe Asn Thr Gly Leu Lys Met Phe Pro Asp Leu Thr Lys Val Tyr Ser 
        115                 120                 125             


Thr Asp Ile Phe Phe Ile Leu Glu Ile Thr Asp Asn Pro Tyr Met Thr 
    130                 135                 140                 


Ser Ile Pro Val Asn Ala Phe Gln Gly Leu Cys Asn Glu Thr Leu Thr 
145                 150                 155                 160 


Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Val Gln Gly Tyr Ala Phe 
                165                 170                 175     


Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu Asn Lys Asn Lys Tyr Leu 
            180                 185                 190         


Thr Val Ile Asp Lys Asp Ala Phe Gly Gly Val Tyr Ser Gly Pro Ser 
        195                 200                 205             


Leu Leu Asp Val Ser Gln Thr Ser Val Thr Ala Leu Pro Ser Lys Gly 
    210                 215                 220                 


Leu Glu His Leu Lys Glu Leu Ile Ala Arg Asn Thr Trp Thr Leu Lys 
225                 230                 235                 240 


Lys Leu Pro Leu Ser Leu Ser Phe Leu His Leu Thr Arg Ala Asp Leu 
                245                 250                 255     


Ser Tyr Pro Ser His Cys Cys Ala Phe Lys Asn Gln Lys Lys Ile Arg 
            260                 265                 270         


Gly Ile Leu Glu Ser Leu Met Cys Asn Glu Ser Ser Met Gln Ser Leu 
        275                 280                 285             


Arg Gln Arg Lys Ser Val Asn Ala Leu Asn Ser Pro Leu His Gln Glu 
    290                 295                 300                 


Tyr Glu Glu Asn Leu Gly Asp Ser Ile Val Gly Tyr Lys Glu Lys Ser 
305                 310                 315                 320 


Lys Phe Gln Asp Thr His Asn Asn Ala His Tyr Tyr Val Phe Phe Glu 
                325                 330                 335     


Glu Gln Glu Asp Glu Ile Ile Gly Phe Gly Gln Glu Leu Lys Asn Pro 
            340                 345                 350         


Gln Glu Glu Thr Leu Gln Ala Phe Asp Ser His Tyr Asp Tyr Thr Ile 
        355                 360                 365             


Cys Gly Asp Ser Glu Asp Met Val Cys Thr Pro Lys Ser Asp Glu Phe 
    370                 375                 380                 


Asn Pro Cys Glu Asp Ile Met Gly Tyr Lys Phe 
385                 390                 395 


<210>  13
<211>  86
<212>  PRT
<213>  ˹

<400>  13

Ala Ile Phe Thr Lys Ala Phe Gln Arg Asp Val Phe Ile Leu Leu Ser 
1               5                   10                  15      


Lys Phe Gly Ile Cys Lys Arg Gln Ala Gln Ala Tyr Arg Gly Gln Arg 
            20                  25                  30          


Val Pro Pro Lys Asn Ser Thr Asp Ile Gln Val Gln Lys Val Thr His 
        35                  40                  45              


Glu Met Arg Gln Gly Leu His Asn Met Glu Asp Val Tyr Glu Leu Ile 
    50                  55                  60                  


Glu Asn Ser His Leu Thr Pro Lys Lys Gln Gly Gln Ile Ser Glu Glu 
65                  70                  75                  80  


Tyr Met Gln Thr Val Leu 
                85      


