                         б

<110>  Ͼѱ¹ҽƼ޹˾
 
<120>  BCMA CAR-TƱ߲ҩеӦ

<130>  0085-PA-010

<160>  52    

<170>  PatentIn version 3.5

<210>  1
<211>  3
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  KOZAK

<400>  1

Ala Ala Thr 
1           


<210>  2
<211>  9
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  KOZAK ᣩ

<400>  2
gccgccacc                                                                9


<210>  3
<211>  21
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD8aź

<400>  3

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  4
<211>  63
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD8aźģ˸ᣩ

<400>  4
atggccctgc ctgtgacagc tctgctcctc cctctggccc tgctgctcca tgccgccaga       60

ccc                                                                     63


<210>  5
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HA-ǩ

<400>  5

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  6
<211>  27
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  HA-ǩᣩ

<400>  6
tacccatacg atgttccaga ttacgct                                           27


<210>  7
<211>  119
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  7

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Ser Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Arg Gly Asp Thr Ile Leu Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  8
<211>  357
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  VHᣩ

<400>  8
cagctgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtagtagtt actactgggg ctggatccgc      120

cagcccccag ggaaggggct ggagtggatt gggagtatct cctatagtgg gagcacctac      180

tacaacccgt ccctcaagag tcgagtcacc atatccgtag acacgtccaa gaaccagttc      240

tccctgaagc tgagttctgt gaccgccgca gacacggcgg tgtactactg cgccagagat      300

cgtggagaca ccatactaga cgtatggggt cagggtacaa tggtcaccgt cagctca         357


<210>  9
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1

<400>  9

Gly Gly Ser Ile Ser Ser Ser Ser Tyr Tyr 
1               5                   10  


<210>  10
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  10

Ile Ser Tyr Ser Gly Ser Thr 
1               5           


<210>  11
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  11

Ala Arg Asp Arg Gly Asp Thr Ile Leu Asp Val 
1               5                   10      


<210>  12
<211>  30
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1ᣩ

<400>  12
ggtggctcca tcagcagtag tagttactac                                        30


<210>  13
<211>  21
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2ᣩ

<400>  13
atctcctata gtgggagcac c                                                 21


<210>  14
<211>  33
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3ᣩ

<400>  14
gccagagatc gtggagacac catactagac gta                                    33


<210>  15
<211>  106
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Lys Tyr Asp Leu Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  16
<211>  318
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  VLᣩ

<400>  16
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcagcaa aaatacgacc tcctcacttt tggcggaggg      300

accaaggttg agatcaaa                                                    318


<210>  17
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<400>  17

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  18
<211>  3
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2

<400>  18

Ala Ala Ser 
1           


<210>  19
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3

<400>  19

Gln Gln Lys Tyr Asp Leu Leu Thr 
1               5               


<210>  20
<211>  18
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1ᣩ

<400>  20
cagagcatta gcagctat                                                     18


<210>  21
<211>  9
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2ᣩ

<400>  21
gctgcatcc                                                                9


<210>  22
<211>  24
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3ᣩ

<400>  22
cagcaaaaat acgacctcct cact                                              24


<210>  23
<211>  18
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  (VL-VH)

<400>  23

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  24
<211>  54
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  (VL-VH)ᣩ

<400>  24
ggcagcacca gcggctccgg caagcctggc tctggcgagg gcagcacaaa ggga             54


<210>  25
<211>  55
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  

<400>  25

Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Cys Asp 
    50                  55  


<210>  26
<211>  165
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ᣩ

<400>  26
ttcgtgcccg tgttcctgcc cgccaaacct accaccaccc ctgcccctag acctcccacc       60

ccagccccaa caatcgccag ccagcctctg tctctgcggc ccgaagcctg tagacctgct      120

gccggcggag ccgtgcacac cagaggcctg gacttcgcct gcgac                      165


<210>  27
<211>  21
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD8aĤ

<400>  27

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  28
<211>  63
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD8aĤᣩ

<400>  28
atctacatct gggcccctct ggccggcacc tgtggcgtgc tgctgctgag cctggtgatc       60

acc                                                                     63


<210>  29
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD28̼ṹ

<400>  29

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  30
<211>  123
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD28̼ṹ򣨺ᣩ

<400>  30
agaagcaagc ggagccggct gctgcacagc gactacatga acatgacccc aagacggcct       60

ggccccaccc ggaagcacta ccagccttac gcccctccca gagacttcgc cgcctaccgg      120

tcc                                                                    123


<210>  31
<211>  42
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  4-1BB̼ṹ

<400>  31

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  32
<211>  126
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  4-1BB̼ṹ򣨺ᣩ

<400>  32
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  33
<211>  112
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD3ưźŴṹ

<400>  33

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  34
<211>  336
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD3ưźŴṹ򣨺ᣩ

<400>  34
agagtgaagt tcagcagatc cgccgacgcc cctgcctacc agcagggaca gaaccagctg       60

tacaacgagc tgaacctggg cagacgggaa gagtacgacg tgctggacaa gcggagaggc      120

cgggaccccg agatgggcgg aaagcccaga cggaagaacc cccaggaagg cctgtataac      180

gaactgcaga aagacaagat ggccgaggcc tacagcgaga tcggcatgaa gggcgagcgg      240

aggcgcggca agggccacga tggcctgtac cagggcctga gcaccgccac caaggacacc      300

tacgacgccc tgcacatgca ggccctgccc cccaga                                336


<210>  35
<211>  18
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  T2A

<400>  35

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  36
<211>  54
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  T2Aᣩ

<400>  36
gagggcagag gaagtcttct aacatgcggt gacgtggagg agaatcccgg ccct             54


<210>  37
<211>  239
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  GFP

<400>  37

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210>  38
<211>  720
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  GFPᣩ

<400>  38
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagtaa      720


<210>  39
<211>  357
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  EGFRt

<400>  39

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu 
        195                 200                 205             


Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys 
    210                 215                 220                 


Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu 
225                 230                 235                 240 


Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met 
                245                 250                 255     


Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala 
            260                 265                 270         


His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val 
        275                 280                 285             


Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His 
    290                 295                 300                 


Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro 
305                 310                 315                 320 


Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala 
                325                 330                 335     


Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly 
            340                 345                 350         


Ile Gly Leu Phe Met 
        355         


<210>  40
<211>  1071
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  EGFRtᣩ

<400>  40
atgctgctgc tcgtgacctc tttactgtta tgtgagctgc cccaccccgc ttttttactg       60

atccctcgta aggtgtgtaa cggaatcggc attggcgagt tcaaggactc tttaagcatc      120

aacgccacaa acatcaagca cttcaagaat tgtacctcca tcagcggcga tttacacatt      180

ctccccgtgg cttttcgtgg cgattccttc acccacaccc cccctctgga cccccaagag      240

ctggacattt taaaaaccgt gaaggagatc accggctttc tgctgatcca agcttggccc      300

gagaatcgta ccgacctcca cgccttcgag aatttagaga ttattcgtgg aaggaccaag      360

cagcacggcc agttctcttt agccgtcgtg tctttaaaca ttaccagcct cggtttaagg      420

tctttaaagg agattagcga cggcgacgtg atcatctccg gcaacaagaa cctctgctac      480

gccaacacca tcaactggaa gaagctgttc ggaaccagcg gccaaaagac caagatcatc      540

agcaatcgtg gagagaactc ttgtaaggcc actggtcaag tttgccacgc cctctgtagc      600

cccgaaggat gttggggccc cgagcctagg gactgtgtta gctgcagaaa cgtgagcaga      660

ggcagagagt gtgtggacaa atgcaattta ctggaaggag agcctaggga gttcgtggag      720

aacagcgaat gtatccagtg ccaccccgag tgtttacctc aagccatgaa catcacttgt      780

accggaaggg gccccgataa ctgcatccaa tgcgcccact acatcgacgg accccactgc      840

gtgaaaactt gtcccgccgg agtgatggga gagaataaca ctttagtgtg gaagtacgcc      900

gacgctggcc acgtctgcca tctgtgccac cccaactgta cctacggctg cactggtccc      960

ggtttagagg gatgtcctac caacggcccc aagatcccct ccatcgccac cggaatggtg     1020

ggcgctctgt tattactgct ggtggtggct ctgggcatcg gtttattcat g              1071


<210>  41
<211>  246
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  scFv0008

<400>  41

Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu Ala Met Ser Leu Gly 
1               5                   10                  15      


Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Thr Ile Leu 
            20                  25                  30          


Gly Ser His Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Thr Leu Leu Ile Gln Leu Ala Ser Asn Val Gln Thr Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Val Ala Val Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      


Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys 
        115                 120                 125             


Gly Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly 
    130                 135                 140                 


Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
145                 150                 155                 160 


Tyr Ser Ile Asn Trp Val Lys Arg Ala Pro Gly Lys Gly Leu Lys Trp 
                165                 170                 175     


Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Tyr Asp 
            180                 185                 190         


Phe Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala 
        195                 200                 205             


Tyr Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp Thr Ala Thr Tyr Phe 
    210                 215                 220                 


Cys Ala Leu Asp Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Ser Val Thr Val Ser Ser 
                245     


<210>  42
<211>  738
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  scFv0008ᣩ

<400>  42
gacatcgtgc tgacccagag cccccccagc ctggccatgt ctctgggcaa gagagccacc       60

atcagctgcc gggccagcga gagcgtgacc atcctgggca gccacctgat ccactggtat      120

cagcagaagc ccggccagcc ccccaccctg ctgatccagc tcgccagcaa tgtgcagacc      180

ggcgtgcccg ccagattcag cggcagcggc agcagaaccg acttcaccct gaccatcgac      240

cccgtggaag aggacgacgt ggccgtgtac tactgcctgc agagccggac catcccccgg      300

acctttggcg gaggcaccaa actggaaatc aagggcagca ccagcggctc cggcaagcct      360

ggctctggcg agggcagcac aaagggacag attcagctgg tgcagagcgg ccctgagctg      420

aagaaacccg gcgagacagt gaagatcagc tgcaaggcct ccggctacac cttcaccgac      480

tacagcatca actgggtgaa aagagcccct ggcaagggcc tgaagtggat gggctggatc      540

aacaccgaga caagagagcc cgcctacgcc tacgacttcc ggggcagatt cgccttcagc      600

ctggaaacca gcgccagcac cgcctacctg cagatcaaca acctgaagta cgaggacacc      660

gccacctact tttgcgccct ggactacagc tacgccatgg actactgggg ccagggcacc      720

agcgtgaccg tgtccagc                                                    738


<210>  43
<211>  243
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  scFv0026

<400>  43

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Lys Tyr Asp Leu Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly Ser 
            100                 105                 110         


Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Leu Gln Leu 
        115                 120                 125             


Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu 
    130                 135                 140                 


Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser Ser Tyr Tyr Trp 
145                 150                 155                 160 


Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser 
                165                 170                 175     


Ile Ser Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg 
            180                 185                 190         


Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu 
        195                 200                 205             


Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp 
    210                 215                 220                 


Arg Gly Asp Thr Ile Leu Asp Val Trp Gly Gln Gly Thr Met Val Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  44
<211>  729
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  scFv0026ᣩ

<400>  44
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcagcaa aaatacgacc tcctcacttt tggcggaggg      300

accaaggttg agatcaaagg cagcaccagc ggctccggca agcctggctc tggcgagggc      360

agcacaaagg gacagctgca gctgcaggag tcgggcccag gactggtgaa gccttcggag      420

accctgtccc tcacctgcac tgtctctggt ggctccatca gcagtagtag ttactactgg      480

ggctggatcc gccagccccc agggaagggg ctggagtgga ttgggagtat ctcctatagt      540

gggagcacct actacaaccc gtccctcaag agtcgagtca ccatatccgt agacacgtcc      600

aagaaccagt tctccctgaa gctgagttct gtgaccgccg cagacacggc ggtgtactac      660

tgcgccagag atcgtggaga caccatacta gacgtatggg gtcagggtac aatggtcacc      720

gtcagctca                                                              729


<210>  45
<211>  482
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CAR0009

<400>  45

Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu Ala Met Ser Leu Gly 
1               5                   10                  15      


Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Thr Ile Leu 
            20                  25                  30          


Gly Ser His Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Thr Leu Leu Ile Gln Leu Ala Ser Asn Val Gln Thr Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Val Ala Val Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      


Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys 
        115                 120                 125             


Gly Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly 
    130                 135                 140                 


Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
145                 150                 155                 160 


Tyr Ser Ile Asn Trp Val Lys Arg Ala Pro Gly Lys Gly Leu Lys Trp 
                165                 170                 175     


Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Tyr Asp 
            180                 185                 190         


Phe Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala 
        195                 200                 205             


Tyr Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp Thr Ala Thr Tyr Phe 
    210                 215                 220                 


Cys Ala Leu Asp Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Ser Val Thr Val Ser Ser Phe Val Pro Val Phe Leu Pro Ala Lys Pro 
                245                 250                 255     


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
            260                 265                 270         


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
        275                 280                 285             


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
    290                 295                 300                 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
305                 310                 315                 320 


Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu 
                325                 330                 335     


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
            340                 345                 350         


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
        355                 360                 365             


Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
    370                 375                 380                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
385                 390                 395                 400 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                405                 410                 415     


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            420                 425                 430         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        435                 440                 445             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    450                 455                 460                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
465                 470                 475                 480 


Pro Arg 
        


<210>  46
<211>  1446
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CAR0009ᣩ

<400>  46
gacatcgtgc tgacccagag cccccccagc ctggccatgt ctctgggcaa gagagccacc       60

atcagctgcc gggccagcga gagcgtgacc atcctgggca gccacctgat ccactggtat      120

cagcagaagc ccggccagcc ccccaccctg ctgatccagc tcgccagcaa tgtgcagacc      180

ggcgtgcccg ccagattcag cggcagcggc agcagaaccg acttcaccct gaccatcgac      240

cccgtggaag aggacgacgt ggccgtgtac tactgcctgc agagccggac catcccccgg      300

acctttggcg gaggcaccaa actggaaatc aagggcagca ccagcggctc cggcaagcct      360

ggctctggcg agggcagcac aaagggacag attcagctgg tgcagagcgg ccctgagctg      420

aagaaacccg gcgagacagt gaagatcagc tgcaaggcct ccggctacac cttcaccgac      480

tacagcatca actgggtgaa aagagcccct ggcaagggcc tgaagtggat gggctggatc      540

aacaccgaga caagagagcc cgcctacgcc tacgacttcc ggggcagatt cgccttcagc      600

ctggaaacca gcgccagcac cgcctacctg cagatcaaca acctgaagta cgaggacacc      660

gccacctact tttgcgccct ggactacagc tacgccatgg actactgggg ccagggcacc      720

agcgtgaccg tgtccagctt cgtgcccgtg ttcctgcccg ccaaacctac caccacccct      780

gcccctagac ctcccacccc agccccaaca atcgccagcc agcctctgtc tctgcggccc      840

gaagcctgta gacctgctgc cggcggagcc gtgcacacca gaggcctgga cttcgcctgc      900

gacatctaca tctgggcccc tctggccggc acctgtggcg tgctgctgct gagcctggtg      960

atcaccctgt actgcaacca ccggaacaga agcaagcgga gccggctgct gcacagcgac     1020

tacatgaaca tgaccccaag acggcctggc cccacccgga agcactacca gccttacgcc     1080

cctcccagag acttcgccgc ctaccggtcc agagtgaagt tcagcagatc cgccgacgcc     1140

cctgcctacc agcagggaca gaaccagctg tacaacgagc tgaacctggg cagacgggaa     1200

gagtacgacg tgctggacaa gcggagaggc cgggaccccg agatgggcgg aaagcccaga     1260

cggaagaacc cccaggaagg cctgtataac gaactgcaga aagacaagat ggccgaggcc     1320

tacagcgaga tcggcatgaa gggcgagcgg aggcgcggca agggccacga tggcctgtac     1380

cagggcctga gcaccgccac caaggacacc tacgacgccc tgcacatgca ggccctgccc     1440

cccaga                                                                1446


<210>  47
<211>  491
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CAR0041

<400>  47

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Asp Ile Val Leu Thr Gln Ser 
1               5                   10                  15      


Pro Pro Ser Leu Ala Met Ser Leu Gly Lys Arg Ala Thr Ile Ser Cys 
            20                  25                  30          


Arg Ala Ser Glu Ser Val Thr Ile Leu Gly Ser His Leu Ile His Trp 
        35                  40                  45              


Tyr Gln Gln Lys Pro Gly Gln Pro Pro Thr Leu Leu Ile Gln Leu Ala 
    50                  55                  60                  


Ser Asn Val Gln Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
65                  70                  75                  80  


Arg Thr Asp Phe Thr Leu Thr Ile Asp Pro Val Glu Glu Asp Asp Val 
                85                  90                  95      


Ala Val Tyr Tyr Cys Leu Gln Ser Arg Thr Ile Pro Arg Thr Phe Gly 
            100                 105                 110         


Gly Gly Thr Lys Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys 
        115                 120                 125             


Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Ile Gln Leu Val Gln 
    130                 135                 140                 


Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys 
145                 150                 155                 160 


Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Ser Ile Asn Trp Val Lys 
                165                 170                 175     


Arg Ala Pro Gly Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Glu 
            180                 185                 190         


Thr Arg Glu Pro Ala Tyr Ala Tyr Asp Phe Arg Gly Arg Phe Ala Phe 
        195                 200                 205             


Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu 
    210                 215                 220                 


Lys Tyr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Leu Asp Tyr Ser Tyr 
225                 230                 235                 240 


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Phe 
                245                 250                 255     


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
                325                 330                 335     


Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
            340                 345                 350         


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
        355                 360                 365             


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


<210>  48
<211>  1473
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CAR0041ᣩ

<400>  48
tacccatacg atgttccaga ttacgctgac atcgtgctga cccagagccc ccccagcctg       60

gccatgtctc tgggcaagag agccaccatc agctgccggg ccagcgagag cgtgaccatc      120

ctgggcagcc acctgatcca ctggtatcag cagaagcccg gccagccccc caccctgctg      180

atccagctcg ccagcaatgt gcagaccggc gtgcccgcca gattcagcgg cagcggcagc      240

agaaccgact tcaccctgac catcgacccc gtggaagagg acgacgtggc cgtgtactac      300

tgcctgcaga gccggaccat cccccggacc tttggcggag gcaccaaact ggaaatcaag      360

ggcagcacca gcggctccgg caagcctggc tctggcgagg gcagcacaaa gggacagatt      420

cagctggtgc agagcggccc tgagctgaag aaacccggcg agacagtgaa gatcagctgc      480

aaggcctccg gctacacctt caccgactac agcatcaact gggtgaaaag agcccctggc      540

aagggcctga agtggatggg ctggatcaac accgagacaa gagagcccgc ctacgcctac      600

gacttccggg gcagattcgc cttcagcctg gaaaccagcg ccagcaccgc ctacctgcag      660

atcaacaacc tgaagtacga ggacaccgcc acctactttt gcgccctgga ctacagctac      720

gccatggact actggggcca gggcaccagc gtgaccgtgt ccagcttcgt gcccgtgttc      780

ctgcccgcca aacctaccac cacccctgcc cctagacctc ccaccccagc cccaacaatc      840

gccagccagc ctctgtctct gcggcccgaa gcctgtagac ctgctgccgg cggagccgtg      900

cacaccagag gcctggactt cgcctgcgac atctacatct gggcccctct ggccggcacc      960

tgtggcgtgc tgctgctgag cctggtgatc accctgtact gcaaccaccg gaacagaagc     1020

aagcggagcc ggctgctgca cagcgactac atgaacatga ccccaagacg gcctggcccc     1080

acccggaagc actaccagcc ttacgcccct cccagagact tcgccgccta ccggtccaga     1140

gtgaagttca gcagatccgc cgacgcccct gcctaccagc agggacagaa ccagctgtac     1200

aacgagctga acctgggcag acgggaagag tacgacgtgc tggacaagcg gagaggccgg     1260

gaccccgaga tgggcggaaa gcccagacgg aagaaccccc aggaaggcct gtataacgaa     1320

ctgcagaaag acaagatggc cgaggcctac agcgagatcg gcatgaaggg cgagcggagg     1380

cgcggcaagg gccacgatgg cctgtaccag ggcctgagca ccgccaccaa ggacacctac     1440

gacgccctgc acatgcaggc cctgcccccc aga                                  1473


<210>  49
<211>  488
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CAR0037

<400>  49

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Asp Ile Gln Met Thr Gln Ser 
1               5                   10                  15      


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
            20                  25                  30          


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
        35                  40                  45              


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
    50                  55                  60                  


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
65                  70                  75                  80  


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Gln Gln Lys Tyr Asp Leu Leu Thr Phe Gly Gly Gly Thr Lys Val 
            100                 105                 110         


Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu 
        115                 120                 125             


Gly Ser Thr Lys Gly Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu 
    130                 135                 140                 


Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly 
145                 150                 155                 160 


Ser Ile Ser Ser Ser Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro 
                165                 170                 175     


Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Ser Tyr Ser Gly Ser Thr 
            180                 185                 190         


Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr 
        195                 200                 205             


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Asp Thr Ile Leu Asp 
225                 230                 235                 240 


Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Phe Val Pro Val 
                245                 250                 255     


Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            260                 265                 270         


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        275                 280                 285             


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    290                 295                 300                 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
305                 310                 315                 320 


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg 
                325                 330                 335     


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
            340                 345                 350         


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
        355                 360                 365             


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg 
                485             


<210>  50
<211>  1464
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CAR0037ᣩ

<400>  50
tacccatacg atgttccaga ttacgctgac atccagatga cccagtctcc atcctccctg       60

tctgcatctg taggagacag agtcaccatc acttgccggg caagtcagag cattagcagc      120

tatttaaatt ggtatcagca gaaaccaggg aaagccccta agctcctgat ctatgctgca      180

tccagtttgc aaagtggggt cccatcaagg ttcagtggca gtggatctgg gacagatttc      240

actctcacca tcagcagtct gcaacctgaa gattttgcaa cttactactg tcagcaaaaa      300

tacgacctcc tcacttttgg cggagggacc aaggttgaga tcaaaggcag caccagcggc      360

tccggcaagc ctggctctgg cgagggcagc acaaagggac agctgcagct gcaggagtcg      420

ggcccaggac tggtgaagcc ttcggagacc ctgtccctca cctgcactgt ctctggtggc      480

tccatcagca gtagtagtta ctactggggc tggatccgcc agcccccagg gaaggggctg      540

gagtggattg ggagtatctc ctatagtggg agcacctact acaacccgtc cctcaagagt      600

cgagtcacca tatccgtaga cacgtccaag aaccagttct ccctgaagct gagttctgtg      660

accgccgcag acacggcggt gtactactgc gccagagatc gtggagacac catactagac      720

gtatggggtc agggtacaat ggtcaccgtc agctcattcg tgcccgtgtt cctgcccgcc      780

aaacctacca ccacccctgc ccctagacct cccaccccag ccccaacaat cgccagccag      840

cctctgtctc tgcggcccga agcctgtaga cctgctgccg gcggagccgt gcacaccaga      900

ggcctggact tcgcctgcga catctacatc tgggcccctc tggccggcac ctgtggcgtg      960

ctgctgctga gcctggtgat caccctgtac tgcaaccacc ggaacagaag caagcggagc     1020

cggctgctgc acagcgacta catgaacatg accccaagac ggcctggccc cacccggaag     1080

cactaccagc cttacgcccc tcccagagac ttcgccgcct accggtccag agtgaagttc     1140

agcagatccg ccgacgcccc tgcctaccag cagggacaga accagctgta caacgagctg     1200

aacctgggca gacgggaaga gtacgacgtg ctggacaagc ggagaggccg ggaccccgag     1260

atgggcggaa agcccagacg gaagaacccc caggaaggcc tgtataacga actgcagaaa     1320

gacaagatgg ccgaggccta cagcgagatc ggcatgaagg gcgagcggag gcgcggcaag     1380

ggccacgatg gcctgtacca gggcctgagc accgccacca aggacaccta cgacgccctg     1440

cacatgcagg ccctgccccc caga                                            1464


<210>  51
<211>  480
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CAR0085CAR0087

<400>  51

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Lys Tyr Asp Leu Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly Ser 
            100                 105                 110         


Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Leu Gln Leu 
        115                 120                 125             


Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu 
    130                 135                 140                 


Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser Ser Tyr Tyr Trp 
145                 150                 155                 160 


Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser 
                165                 170                 175     


Ile Ser Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg 
            180                 185                 190         


Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu 
        195                 200                 205             


Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp 
    210                 215                 220                 


Arg Gly Asp Thr Ile Leu Asp Val Trp Gly Gln Gly Thr Met Val Thr 
225                 230                 235                 240 


Val Ser Ser Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr 
                245                 250                 255     


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
            260                 265                 270         


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
        275                 280                 285             


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
    290                 295                 300                 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
305                 310                 315                 320 


Tyr Cys Asn His Arg Asn Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
                325                 330                 335     


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
            340                 345                 350         


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        355                 360                 365             


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
    370                 375                 380                 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
385                 390                 395                 400 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
                405                 410                 415     


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
            420                 425                 430         


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
        435                 440                 445             


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
    450                 455                 460                 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 475                 480 


<210>  52
<211>  1440
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CAR0085CAR0087ᣩ

<400>  52
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcagcaa aaatacgacc tcctcacttt tggcggaggg      300

accaaggttg agatcaaagg cagcaccagc ggctccggca agcctggctc tggcgagggc      360

agcacaaagg gacagctgca gctgcaggag tcgggcccag gactggtgaa gccttcggag      420

accctgtccc tcacctgcac tgtctctggt ggctccatca gcagtagtag ttactactgg      480

ggctggatcc gccagccccc agggaagggg ctggagtgga ttgggagtat ctcctatagt      540

gggagcacct actacaaccc gtccctcaag agtcgagtca ccatatccgt agacacgtcc      600

aagaaccagt tctccctgaa gctgagttct gtgaccgccg cagacacggc ggtgtactac      660

tgcgccagag atcgtggaga caccatacta gacgtatggg gtcagggtac aatggtcacc      720

gtcagctcat tcgtgcccgt gttcctgccc gccaaaccta ccaccacccc tgcccctaga      780

cctcccaccc cagccccaac aatcgccagc cagcctctgt ctctgcggcc cgaagcctgt      840

agacctgctg ccggcggagc cgtgcacacc agaggcctgg acttcgcctg cgacatctac      900

atctgggccc ctctggccgg cacctgtggc gtgctgctgc tgagcctggt gatcaccctg      960

tactgcaacc accggaacaa acggggcaga aagaaactcc tgtatatatt caaacaacca     1020

tttatgagac cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa     1080

gaagaagaag gaggatgtga actgagagtg aagttcagca gatccgccga cgcccctgcc     1140

taccagcagg gacagaacca gctgtacaac gagctgaacc tgggcagacg ggaagagtac     1200

gacgtgctgg acaagcggag aggccgggac cccgagatgg gcggaaagcc cagacggaag     1260

aacccccagg aaggcctgta taacgaactg cagaaagaca agatggccga ggcctacagc     1320

gagatcggca tgaagggcga gcggaggcgc ggcaagggcc acgatggcct gtaccagggc     1380

ctgagcaccg ccaccaagga cacctacgac gccctgcaca tgcaggccct gccccccaga     1440


