                         б

<110>  Ƽ޹˾(BEIJING GENECRADLE PHARMACEUTICAL CO., LTD.)
 
<120>  ӱϲĻƹ塢ҩͷ

<130>  PF 220373PCT

<160>  13    

<170>  PatentIn version 3.3

<210>  1
<211>  631
<212>  DNA
<213>  artificial

<220>
<223>  synthetic

<400>  1
attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt tccattgacg     60

tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag tgtatcatat    120

gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc attatgccca    180

gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag tcatcgctat    240

tacccatggt cgaggtgagc cccacgttct gcttcactct ccccatctcc cccccctccc    300

cacccccaat tttgtattta tttatttttt aattattttg tgcagcgatg ggggcggggg    360

gggggggggg gcgcgcgcca ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc    420

ggagaggtgc ggcggcagcc aatcagagcg gcgcgctccg aaagtttcct tttatggcga    480

ggcggcggcg gcggcggccc tataaaaagc gaagcgcgcg gcgggcgacg cgctatgcgg    540

ccgcgtgagt gagtgatttg atctaaacgc ctttttgtaa tcaagtgact gtgtgtgtgt    600

gtatctgagt gcctgattct tttcatcaca g                                   631


<210>  2
<211>  631
<212>  DNA
<213>  artificial

<220>
<223>  synthetic

<400>  2
attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt tccattgacg     60

tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag tgtatcatat    120

gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc attatgccca    180

gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag tcatcgctat    240

tacccatggt cgaggtgagc cccacgttct gcttcactct ccccatctcc cccccctccc    300

cacccccaat tttgtattta tttatttttt aattattttg tgcagcgatg ggggcggggg    360

gggggggggg gcgcgcgcca ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc    420

ggagaggtgc ggcggcagcc aatcagagcg gcgcgctccg aaagtttcct tttatggcga    480

ggcggcggcg gcggcggccc tataaaaagc gaagcgcgcg gcgggcgacg cgctatgcgg    540

ccgcgtgagt gagtgatttg atctaaaagc ctttttgtaa tcaagtgact gtgtgtgtgt    600

gtatctgagt gcctgattct tttcatcaca g                                   631


<210>  3
<211>  631
<212>  DNA
<213>  artificial 

<220>
<223>  synthetic

<400>  3
attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt tccattgacg     60

tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag tgtatcatat    120

gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc attatgccca    180

gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag tcatcgctat    240

tacccatggt cgaggtgagc cccacgttct gcttcactct ccccatctcc cccccctccc    300

cacccccaat tttgtattta tttatttttt aattattttg tgcagcgatg ggggcggggg    360

gggggggggg gcgcgcgcca ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc    420

ggagaggtgc ggcggcagcc aatcagagcg gcgcgctccg aaagtttcct tttatggcga    480

ggcggcggcg gcggcggccc tataaaaagc gaagcgcgcg gcgggcgacg cgctatgcgg    540

ccgcgtgagt gagtgatttg atctaaaggc ctttttgtaa tcaagtgact gtgtgtgtgt    600

gtatctgagt gcctgattct tttcatcaca g                                   631


<210>  4
<211>  631
<212>  DNA
<213>  artificial

<220>
<223>  synthetic

<400>  4
attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt tccattgacg     60

tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag tgtatcatat    120

gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc attatgccca    180

gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag tcatcgctat    240

tacccatggt cgaggtgagc cccacgttct gcttcactct ccccatctcc cccccctccc    300

cacccccaat tttgtattta tttatttttt aattattttg tgcagcgatg ggggcggggg    360

gggggggggg gcgcgcgcca ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc    420

ggagaggtgc ggcggcagcc aatcagagcg gcgcgctccg aaagtttcct tttatggcga    480

ggcggcggcg gcggcggccc tataaaaagc gaagcgcgcg gcgggcgacg cgctatgcgg    540

ccgcgtgagt gagtgatttg atctaaatgc ctttttgtaa tcaagtgact gtgtgtgtgt    600

gtatctgagt gcctgattct tttcatcaca g                                   631


<210>  5
<211>  145
<212>  DNA
<213>  artificial

<220>
<223>  synthetic

<400>  5
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc     60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg    120

gccaactcca tcactagggg ttcct                                          145


<210>  6
<211>  121
<212>  DNA
<213>  artificial

<220>
<223>  synthetic

<400>  6
ccactccctc tctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc     60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca    120

a                                                                    121


<210>  7
<211>  230
<212>  DNA
<213>  artificial

<220>
<223>  synthetic

<400>  7
gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc     60

ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg    120

cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg    180

gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat               230


<210>  8
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  synthetic

<400>  8
gttcccatag taacgccaat aggg                                            24


<210>  9
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  synthetic

<400>  9
cccataaggt catgtactgg gcat                                            24


<210>  10
<211>  2868
<212>  DNA
<213>  artificial

<220>
<223>  synthetic

<400>  10
gccaccatgg gcgtgcggca cccaccttgc tctcacagac tgctggccgt gtgcgcactg     60

gtgagcctgg caaccgccgc cctgctgggc cacatcctgc tgcacgactt cctgctggtg    120

cccagggagc tgtccggaag ctccccagtg ctggaggaga cccacccagc acaccagcag    180

ggcgcctcta ggccaggccc ccgcgatgca caggcacacc caggcaggcc ccgcgccgtg    240

ccaacccagt gcgacgtgcc acccaacagc aggtttgact gtgcccccga taaggccatc    300

acacaggagc agtgcgaggc aaggggatgc tgttatatcc ctgcaaagca gggactgcag    360

ggagcacaga tgggacagcc atggtgtttc tttcctccat cttaccccag ctataagctg    420

gagaatctgt ctagctccga gatgggctac acagccaccc tgacaagaac cacaccaaca    480

ttctttccca aggatatcct gaccctgagg ctggacgtga tgatggagac agagaaccgc    540

ctgcacttca ccatcaagga tcccgccaat cggagatatg aggtgcctct ggagacccca    600

cacgtgcact ctagggcccc tagcccactg tactccgtgg agttctctga ggagccattt    660

ggcgtgatcg tgaggcgcca gctggatggc cgcgtgctgc tgaacaccac agtggccccc    720

ctgttctttg ccgaccagtt cctgcagctg agcacatccc tgccctccca gtatatcacc    780

ggcctggccg agcacctgtc tcctctgatg ctgtctacca gctggacacg gatcaccctg    840

tggaacagag acctggcacc aacccctgga gcaaatctgt acggcagcca ccccttctat    900

ctggccctgg aggatggagg atccgcccac ggcgtgtttc tgctgaactc taatgccatg    960

gacgtggtgc tgcagccaag ccccgccctg tcctggaggt ctaccggcgg catcctggac   1020

gtgtacatct tcctgggccc tgagccaaag tccgtggtgc agcagtacct ggacgtggtg   1080

ggctatcctt tcatgccccc ttactgggga ctgggatttc acctgtgcag atggggctat   1140

tctagcacag ccatcaccag gcaggtggtg gagaacatga cccgcgccca ctttccactg   1200

gatgtgcagt ggaatgacct ggattacatg gactcccgga gagacttcac cttcaacaag   1260

gacggcttcc gggattttcc agcaatggtg caggagctgc accagggcgg caggcgctac   1320

atgatgatcg tggatcctgc aatctcctct agcggacctg caggaagcta cagaccatat   1380

gacgagggcc tgcggagagg cgtgttcatc acaaacgaga ccggccagcc tctgatcggc   1440

aaggtctggc caggctccac cgccttccca gacttcacca atccaaccgc cctggcatgg   1500

tgggaggaca tggtggccga gttccacgac caggtgcctt ttgatggcat gtggatcgac   1560

atgaacgagc catctaattt catcagggga agcgaggacg gatgcccaaa caatgagctg   1620

gagaatccac catatgtgcc tggagtggtg ggaggcacac tgcaggcagc aaccatctgt   1680

gcctcctctc accagtttct gtctacacac tataacctgc acaatctgta cggactgacc   1740

gaggcaatcg caagccacag agccctggtg aaggcacggg gcacaagacc tttcgtgatc   1800

tcccggtcta cctttgccgg acacggcaga tacgcaggac actggaccgg cgacgtgtgg   1860

agctcctggg agcagctggc ctctagcgtg ccagagatcc tgcagttcaa cctgctgggc   1920

gtgcccctgg tgggagcaga cgtgtgcggc tttctgggca atacaagcga ggagctgtgc   1980

gtgcggtgga cccagctggg agccttctat ccctttatgc gcaaccacaa tagcctgctg   2040

tccctgcctc aggagccata cagcttctcc gagcctgccc agcaggccat gaggaaggcc   2100

ctgacactgc gctatgccct gctgccacac ctgtacaccc tgtttcacca ggcacacgtg   2160

gcaggagaga cagtggccag gcccctgttc ctggagtttc ctaaggattc ctctacctgg   2220

acagtggacc accagctgct gtggggagag gccctgctga tcacccccgt gctgcaggca   2280

ggcaaggcag aggtgacagg ctatttccct ctgggcacat ggtacgatct gcagaccgtg   2340

ccagtggagg ccctgggaag cctgcctcca ccacctgcag caccaaggga gcctgccatc   2400

cactccgagg gacagtgggt gacactgcca gcacctctgg acaccatcaa cgtgcacctg   2460

cgggccggct atatcatccc actgcaggga cctggactga ccacaaccga gagcagacag   2520

cagccaatgg cactggcagt ggccctgacc aagggaggag aggcaagggg agagctgttc   2580

tgggacgatg gcgagtccct ggaggtgctg gagagaggcg cctacacaca ggtcatcttc   2640

ctggcccgga acaatacaat cgtgaatgag ctggtgagag tgacctctga gggagcagga   2700

ctgcagctgc agaaggtgac agtgctggga gtggcaaccg caccacagca ggtgctgtcc   2760

aacggcgtgc ccgtgagcaa tttcacatac tcccctgata ccaaggtgct ggacatctgc   2820

gtgagcctgc tgatgggcga gcagtttctg gtgtcctggt gttagtaa                2868


<210>  11
<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  synthetic

<400>  11
tccataaagt aggaaacact aca                                             23


<210>  12
<211>  46
<212>  DNA
<213>  artificial 

<220>
<223>  synthetic

<400>  12
tccataaagt aggaaacact acatccataa agtaggaaac actaca                    46


<210>  13
<211>  952
<212>  PRT
<213>  human

<400>  13

Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
1               5                   10                  15      


Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile Leu Leu 
            20                  25                  30          


His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val 
        35                  40                  45              


Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly 
    50                  55                  60                  


Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr 
65                  70                  75                  80  


Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys 
                85                  90                  95      


Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro 
            100                 105                 110         


Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe 
        115                 120                 125             


Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser 
    130                 135                 140                 


Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
145                 150                 155                 160 


Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
                165                 170                 175     


Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu 
            180                 185                 190         


Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu 
        195                 200                 205             


Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg 
    210                 215                 220                 


Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe 
225                 230                 235                 240 


Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr 
                245                 250                 255     


Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser 
            260                 265                 270         


Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly 
        275                 280                 285             


Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly 
    290                 295                 300                 


Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val 
305                 310                 315                 320 


Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile 
                325                 330                 335     


Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln 
            340                 345                 350         


Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly 
        355                 360                 365             


Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr 
    370                 375                 380                 


Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val 
385                 390                 395                 400 


Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe 
                405                 410                 415     


Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His 
            420                 425                 430         


Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser 
        435                 440                 445             


Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg 
    450                 455                 460                 


Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val 
465                 470                 475                 480 


Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu 
                485                 490                 495     


Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe 
            500                 505                 510         


Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly 
        515                 520                 525             


Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val 
    530                 535                 540                 


Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser 
545                 550                 555                 560 


Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
                565                 570                 575     


Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly 
            580                 585                 590         


Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg 
        595                 600                 605             


Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu 
    610                 615                 620                 


Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro 
625                 630                 635                 640 


Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu 
                645                 650                 655     


Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg 
            660                 665                 670         


Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser 
        675                 680                 685             


Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
    690                 695                 700                 


Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly 
705                 710                 715                 720 


Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser 
                725                 730                 735     


Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile 
            740                 745                 750         


Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro 
        755                 760                 765             


Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly 
    770                 775                 780                 


Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser 
785                 790                 795                 800 


Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val 
                805                 810                 815     


His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr 
            820                 825                 830         


Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr 
        835                 840                 845             


Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser 
    850                 855                 860                 


Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala 
865                 870                 875                 880 


Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly 
                885                 890                 895     


Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala 
            900                 905                 910         


Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr 
        915                 920                 925             


Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly 
    930                 935                 940                 


Glu Gln Phe Leu Val Ser Trp Cys 
945                 950         


