﻿                         序列表

<110>  中山大学

<120>  一种寡核苷酸RNA双链分子及其在制备治疗恶性肿瘤药物中的应用

<160>  6

<170>  SIPOSequenceListing 1.0

<210>  2
<211>  21
<212>  RNA
<213>  寡核苷酸RNA双链分子(siRNA-1)

<400>  2
gaauuacauc gagcacgugc u                                                  21

<210>  2
<211>  21
<212>  RNA
<213>  寡核苷酸RNA双链分子(siRNA-1)

<400>  2
cuuaauguag cucgugcacg a                                                  21

<210>  3
<211>  21
<212>  RNA
<213>  寡核苷酸RNA双链分子(siRNA-2)

<400>  3
gacgaucgac agccucauug a                                                  21

<210>  4
<211>  21
<212>  RNA
<213>  寡核苷酸RNA双链分子(siRNA-2)

<400>  4
cugcuagcug ucggaguaac u                                                  21

<210>  5
<211>  1848
<212>  DNA/RNA
<213>  VGF基因CDS区序列(VGF基因CDS区序列)

<400>  5
atgaaagccc tcagattgtc ggcttccgcc ctcttctgcc ttctgctgat caacgggtta        60
ggggcagcac cccctggtcg ccctgaggcg cagcctcctc ctctcagctc tgagcataaa       120
gagccggtag ccggggacgc agtgcccggg ccaaaggatg gcagcgcccc agaggtccga       180
ggcgctcgga attccgagcc gcaggacgag ggagagcttt tccagggcgt ggatccccgg       240
gcgctggccg cggtgctgct gcaggcactc gaccgtcccg cctcaccccc ggcaccaagc       300
ggctcccagc aggggccgga ggaagaagca gctgaagctc tgctgaccga gaccgtgcgc       360
agccagaccc acagcctccc ggcgccggag agcccggagc ccgcggctcc gcctcgccct       420
cagactccgg agaatgggcc cgaggcgagc gatccctccg aggagctcga ggcgctagcg       480
tccctgctcc aggaactgcg agatttcagt ccaagtagcg ccaagcgcca gcaggagacg       540
gcggcagcag agacggaaac ccgcacgcac acgctgaccc gagtgaatct ggagagcccg       600
gggccagagc gcgtatggcg cgcttcctgg ggagagttcc aggcgcgtgt cccggagcgc       660
gcgcccctgc cgcccccggc cccctctcaa ttccaggcgc gtatgcccga cagcgggccc       720
cttcccgaaa cccacaagtt cggggaagga gtgtcctccc ccaaaacaca cctaggcgag       780
gcattggcac ccctgtccaa ggcgtaccaa ggcgtggccg ccccgttccc caaggcgcgc       840
cggccggaga gcgcactcct gggcggctcc gaggcgggcg agcgccttct ccagcaaggg       900
ctggcgcagg tggaggccgg gcggcggcag gcggaggcca cgcggcaggc cgcggcgcag       960
gaagagcggc tggccgacct cgcctcggac ctgctgctcc agtatttgct gcagggcggg      1020
gcccggcagc gcggcctcgg gggtcggggg ctgcaggagg cggcggagga gcgagagagt      1080
gcaagggagg aggaggaggc ggagcaggag agacgcggcg gggaggagag ggtgggggaa      1140
gaggatgagg aggcggccga ggcggaggca gaggcggagg aggcggagag ggcgcggcag      1200
aacgcgctcc tgttcgcgga ggaggaggac ggggaagccg gcgccgagga caagcgctcc      1260
caggaggaga cgccgggcca ccggcggaag gaggccgagg ggacagagga gggcggggag      1320
gaggaggacg acgaggagat ggatccgcag acgatcgaca gcctcattga gctgtccacc      1380
aaactccacc tgccagcgga cgacgtggtc agcatcatcg aggaggtgga ggagaagcgg      1440
aagcggaaga agaacgcccc tcccgagccc gtgccgcccc cccgtgccgc ccccgccccc      1500
acccacgtcc gctccccgca gcccccgccc cccgcccccg ctcccgcacg agacgagctg      1560
ccggactgga acgaggtgct cccgccctgg gatcgggagg aggacgaggt gtacccgcca      1620
gggccgtacc accctttccc caactacatc cggccgcgga cactgcagcc gccctcggcc      1680
ttgcgccgcc gccactacca ccacgccttg ccgccttcgc gccactatcc cggccgggag      1740
gcccaggcgc ggcgcgcgca ggaggaggcg gaggcggagg agcgccggct gcaggagcag      1800
gaggagctgg agaattacat cgagcacgtg ctgctccggc gcccgtga                   1848

<210>  6
<211>  615
<212>  PRT
<213>  VGF蛋白序列(VGF蛋白序列)

<400>  6
Met Lys Ala Leu Arg Leu Ser Ala Ser Ala Leu Phe Cys Leu Leu Leu 
1               5                   10                  15      
Ile Asn Gly Leu Gly Ala Ala Pro Pro Gly Arg Pro Glu Ala Gln Pro 
            20                  25                  30          
Pro Pro Leu Ser Ser Glu His Lys Glu Pro Val Ala Gly Asp Ala Val 
        35                  40                  45              
Pro Gly Pro Lys Asp Gly Ser Ala Pro Glu Val Arg Gly Ala Arg Asn 
    50                  55                  60                  
Ser Glu Pro Gln Asp Glu Gly Glu Leu Phe Gln Gly Val Asp Pro Arg 
65                  70                  75                  80  
Ala Leu Ala Ala Val Leu Leu Gln Ala Leu Asp Arg Pro Ala Ser Pro 
                85                  90                  95      
Pro Ala Pro Ser Gly Ser Gln Gln Gly Pro Glu Glu Glu Ala Ala Glu 
            100                 105                 110         
Ala Leu Leu Thr Glu Thr Val Arg Ser Gln Thr His Ser Leu Pro Ala 
        115                 120                 125             
Pro Glu Ser Pro Glu Pro Ala Ala Pro Pro Arg Pro Gln Thr Pro Glu 
    130                 135                 140                 
Asn Gly Pro Glu Ala Ser Asp Pro Ser Glu Glu Leu Glu Ala Leu Ala 
145                 150                 155                 160 
Ser Leu Leu Gln Glu Leu Arg Asp Phe Ser Pro Ser Ser Ala Lys Arg 
                165                 170                 175     
Gln Gln Glu Thr Ala Ala Ala Glu Thr Glu Thr Arg Thr His Thr Leu 
            180                 185                 190         
Thr Arg Val Asn Leu Glu Ser Pro Gly Pro Glu Arg Val Trp Arg Ala 
        195                 200                 205             
Ser Trp Gly Glu Phe Gln Ala Arg Val Pro Glu Arg Ala Pro Leu Pro 
    210                 215                 220                 
Pro Pro Ala Pro Ser Gln Phe Gln Ala Arg Met Pro Asp Ser Gly Pro 
225                 230                 235                 240 
Leu Pro Glu Thr His Lys Phe Gly Glu Gly Val Ser Ser Pro Lys Thr 
                245                 250                 255     
His Leu Gly Glu Ala Leu Ala Pro Leu Ser Lys Ala Tyr Gln Gly Val 
            260                 265                 270         
Ala Ala Pro Phe Pro Lys Ala Arg Arg Pro Glu Ser Ala Leu Leu Gly 
        275                 280                 285             
Gly Ser Glu Ala Gly Glu Arg Leu Leu Gln Gln Gly Leu Ala Gln Val 
    290                 295                 300                 
Glu Ala Gly Arg Arg Gln Ala Glu Ala Thr Arg Gln Ala Ala Ala Gln 
305                 310                 315                 320 
Glu Glu Arg Leu Ala Asp Leu Ala Ser Asp Leu Leu Leu Gln Tyr Leu 
                325                 330                 335     
Leu Gln Gly Gly Ala Arg Gln Arg Gly Leu Gly Gly Arg Gly Leu Gln 
            340                 345                 350         
Glu Ala Ala Glu Glu Arg Glu Ser Ala Arg Glu Glu Glu Glu Ala Glu 
        355                 360                 365             
Gln Glu Arg Arg Gly Gly Glu Glu Arg Val Gly Glu Glu Asp Glu Glu 
    370                 375                 380                 
Ala Ala Glu Ala Glu Ala Glu Ala Glu Glu Ala Glu Arg Ala Arg Gln 
385                 390                 395                 400 
Asn Ala Leu Leu Phe Ala Glu Glu Glu Asp Gly Glu Ala Gly Ala Glu 
                405                 410                 415     
Asp Lys Arg Ser Gln Glu Glu Thr Pro Gly His Arg Arg Lys Glu Ala 
            420                 425                 430         
Glu Gly Thr Glu Glu Gly Gly Glu Glu Glu Asp Asp Glu Glu Met Asp 
        435                 440                 445             
Pro Gln Thr Ile Asp Ser Leu Ile Glu Leu Ser Thr Lys Leu His Leu 
    450                 455                 460                 
Pro Ala Asp Asp Val Val Ser Ile Ile Glu Glu Val Glu Glu Lys Arg 
465                 470                 475                 480 
Lys Arg Lys Lys Asn Ala Pro Pro Glu Pro Val Pro Pro Pro Arg Ala 
                485                 490                 495     
Ala Pro Ala Pro Thr His Val Arg Ser Pro Gln Pro Pro Pro Pro Ala 
            500                 505                 510         
Pro Ala Pro Ala Arg Asp Glu Leu Pro Asp Trp Asn Glu Val Leu Pro 
        515                 520                 525             
Pro Trp Asp Arg Glu Glu Asp Glu Val Tyr Pro Pro Gly Pro Tyr His 
    530                 535                 540                 
Pro Phe Pro Asn Tyr Ile Arg Pro Arg Thr Leu Gln Pro Pro Ser Ala 
545                 550                 555                 560 
Leu Arg Arg Arg His Tyr His His Ala Leu Pro Pro Ser Arg His Tyr 
                565                 570                 575     
Pro Gly Arg Glu Ala Gln Ala Arg Arg Ala Gln Glu Glu Ala Glu Ala 
            580                 585                 590         
Glu Glu Arg Arg Leu Gln Glu Gln Glu Glu Leu Glu Asn Tyr Ile Glu 
        595                 600                 605             
His Val Leu Leu Arg Arg Pro 
    610                 615 

