﻿                         序列表

<110>  深圳市元谷生物科技有限公司

<120>  一种结合人淋巴细胞活化基因3(LAG-3)的抗体及其用途

<130>  GAI21CN4670P

<160>  14

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  120
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  1
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Thr Tyr Ser Glu Tyr 
            20                  25                  30          
Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asn His Arg Gly Ser Thr Tyr Ser Asn Pro Ser Leu Lys 
    50                  55                  60                  
Ser Arg Val Thr Leu Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Gly Tyr Ser Asp Tyr Ser Tyr Asn Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 

<210>  2
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  2
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asn Ala Ser Asn Arg Ala Asn Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Asn Leu Glu Ile Lys 
            100                 105         

<210>  3
<211>  360
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  3
caggtgcaac tgcagcagtg gggtgctggc ctgctgaaac caagcgagac actgtctctg        60
acctgtgccg tgtacggcgg cacctactct gagtactact ggaattggat caggcagcct       120
cctggcaagg gcctcgagtg gatcggcgag atcaaccacc ggggctccac ctacagtaat       180
cctagcctga agtctagagt gaccctgtcc ctggacacct ccaagaacca gttcagcctg       240
aagctgagat ctgttaccgc cgccgacaca gctgtgtact actgcgccag aggctactcc       300
gactactcct ataactggtt cgatccttgg ggccaaggca ccctggtcac cgtcagctct       360

<210>  4
<211>  321
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  4
gagattgtgc tgacccagtc tcctgctacc ctgtctctgt cccctggcga aagagccacc        60
ctctcttgcc gggcctctca gtccatctcc tcttatctgg cttggtacca gcagaaacca       120
ggccaggctc ctagactgct gatctacaac gcctccaacc gggccaacgg catccctgcc       180
cggttctccg gctctggcag cggcactgat ttcacactga ccatcagcag cctggaacct       240
gaggactttg ctgtgtacta ctgtcaacag agatccaact accccctgac cttcggccag       300
ggcaccaacc tggaaatcaa g                                                 321

<210>  5
<211>  5
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  5
Glu Tyr Tyr Trp Asn 
1               5   

<210>  6
<211>  16
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  6
Glu Ile Asn His Arg Gly Ser Thr Tyr Ser Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      

<210>  7
<211>  12
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  7
Gly Tyr Ser Asp Tyr Ser Tyr Asn Trp Phe Asp Pro 
1               5                   10          

<210>  8
<211>  13
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  8
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala Trp Tyr 
1               5                   10              

<210>  9
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  9
Asn Ala Ser Asn Arg Ala Asn 
1               5           

<210>  10
<211>  9
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  10
Gln Gln Arg Ser Asn Tyr Pro Leu Thr 
1               5                   

<210>  11
<211>  446
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  11
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Thr Tyr Ser Glu Tyr 
            20                  25                  30          
Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asn His Arg Gly Ser Thr Tyr Ser Asn Pro Ser Leu Lys 
    50                  55                  60                  
Ser Arg Val Thr Leu Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Gly Tyr Ser Asp Tyr Ser Tyr Asn Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             
Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 
Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         
Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         
Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     
Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     

<210>  12
<211>  214
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  12
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asn Ala Ser Asn Arg Ala Asn Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Asn Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210>  13
<211>  1338
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  13
caggtgcaac tgcagcagtg gggtgctggc ctgctgaaac caagcgagac actgtctctg        60
acctgtgccg tgtacggcgg cacctactct gagtactact ggaattggat caggcagcct       120
cctggcaagg gcctcgagtg gatcggcgag atcaaccacc ggggctccac ctacagtaat       180
cctagcctga agtctagagt gaccctgtcc ctggacacct ccaagaacca gttcagcctg       240
aagctgagat ctgttaccgc cgccgacaca gctgtgtact actgcgccag aggctactcc       300
gactactcct ataactggtt cgatccttgg ggccaaggca ccctggtcac cgtcagctct       360
gctagcacaa agggaccttc cgtgttccca ctggccccat gctccagaag cacatctgag       420
tccaccgccg ctctgggctg tctggtgaag gactacttcc ctgagccagt gaccgtgtcc       480
tggaacagcg gcgccctgac atccggagtg cacacctttc cagctgtgct gcagtccagc       540
ggcctgtaca gcctgtcttc cgtggtgaca gtgcccagct cttccctggg caccaagaca       600
tatacctgca acgtggacca taagcctagc aataccaagg tggataagag ggtggagtct       660
aagtacggac caccttgccc accatgtcca gctcctgagt ttctgggagg accatccgtg       720
ttcctgtttc ctccaaagcc taaggacacc ctgatgatct ctcggacacc tgaggtgacc       780
tgcgtggtgg tggacgtgtc ccaggaggat ccagaggtgc agttcaactg gtacgtggat       840
ggcgtggagg tgcacaatgc taagaccaag ccaagagagg agcagtttaa tagcacatac       900
cgcgtggtgt ctgtgctgac cgtgctgcat caggattggc tgaacggcaa ggagtataag       960
tgcaaggtga gcaataaggg cctgcccagc tctatcgaga agacaatctc taaggctaag      1020
ggacagccta gggagccaca ggtgtacacc ctgccccctt cccaggagga gatgacaaag      1080
aaccaggtga gcctgacctg tctggtgaag ggcttctatc catctgacat cgctgtggag      1140
tgggagtcca atggccagcc cgagaacaat tacaagacca caccacccgt gctggactct      1200
gatggctcct tctttctgta ttccaggctg acagtggata agagccggtg gcaggagggc      1260
aacgtgttta gctgctctgt gatgcacgag gctctgcaca atcattatac ccagaagtcc      1320
ctgagcctgt ctctgggc                                                    1338

<210>  14
<211>  642
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  14
gagattgtgc tgacccagtc tcctgctacc ctgtctctgt cccctggcga aagagccacc        60
ctctcttgcc gggcctctca gtccatctcc tcttatctgg cttggtacca gcagaaacca       120
ggccaggctc ctagactgct gatctacaac gcctccaacc gggccaacgg catccctgcc       180
cggttctccg gctctggcag cggcactgat ttcacactga ccatcagcag cctggaacct       240
gaggactttg ctgtgtacta ctgtcaacag agatccaact accccctgac cttcggccag       300
ggcaccaacc tggaaatcaa gcgtacggtg gctgctccat ctgtcttcat cttcccacca       360
tctgatgagc agctgaagtc tggaactgcc tctgtggtgt gcctgctgaa taacttctat       420
cccagagagg ccaaagtgca gtggaaggtg gataacgccc tgcagtccgg caactcccag       480
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc       540
ctgagcaaag ccgactacga gaagcacaaa gtctacgcct gcgaggtcac ccatcagggc       600
ctgagcagcc ccgtcacaaa gagcttcaac aggggagagt gt                          642

