﻿                         序列表

<110>  凯莱英医药集团（天津）股份有限公司

<120>  酯酶突变体及其应用

<130>  PN158122KLY

<160>  2

<170>   PatentIn version 3.5

<210>  1
<211>  264
<212>  PRT
<213>  印度萝芙木(Rauvolfia serpentina)

<400>  1
Met His Ser Ala Ala Asn Ala Lys Gln Gln Lys His Phe Val Leu Val 
1               5                   10                  15      
His Gly Gly Cys Leu Gly Ala Trp Ile Trp Tyr Lys Leu Lys Pro Leu 
            20                  25                  30          
Leu Glu Ser Ala Gly His Lys Val Thr Ala Val Asp Leu Ser Ala Ala 
        35                  40                  45              
Gly Ile Asn Pro Arg Arg Leu Asp Glu Ile His Thr Phe Arg Asp Tyr 
    50                  55                  60                  
Ser Glu Pro Leu Met Glu Val Met Ala Ser Ile Pro Pro Asp Glu Lys 
65                  70                  75                  80  
Val Val Leu Leu Gly His Ser Phe Gly Gly Met Ser Leu Gly Leu Ala 
                85                  90                  95      
Met Glu Thr Tyr Pro Glu Lys Ile Ser Val Ala Val Phe Met Ser Ala 
            100                 105                 110         
Met Met Pro Asp Pro Asn His Ser Leu Thr Tyr Pro Phe Glu Lys Tyr 
        115                 120                 125             
Asn Glu Lys Cys Pro Ala Asp Met Met Leu Asp Ser Gln Phe Ser Thr 
    130                 135                 140                 
Tyr Gly Asn Pro Glu Asn Pro Gly Met Ser Met Ile Leu Gly Pro Gln 
145                 150                 155                 160 
Phe Met Ala Leu Lys Met Phe Gln Asn Cys Ser Val Glu Asp Leu Glu 
                165                 170                 175     
Leu Ala Lys Met Leu Thr Arg Pro Gly Ser Leu Phe Phe Gln Asp Leu 
            180                 185                 190         
Ala Lys Ala Lys Lys Phe Ser Thr Glu Arg Tyr Gly Ser Val Lys Arg 
        195                 200                 205             
Ala Tyr Ile Phe Cys Asn Glu Asp Lys Ser Phe Pro Val Glu Phe Gln 
    210                 215                 220                 
Lys Trp Phe Val Glu Ser Val Gly Ala Asp Lys Val Lys Glu Ile Lys 
225                 230                 235                 240 
Glu Ala Asp His Met Gly Met Leu Ser Gln Pro Arg Glu Val Cys Lys 
                245                 250                 255     
Cys Leu Leu Asp Ile Ser Asp Ser 
            260                 

<210>  2
<211>  795
<212>  DNA
<213>  印度萝芙木(Rauvolfia serpentina)

<220>
<221>  misc_feature
<222>  (1)..(795)
<223>  针对大肠杆菌进行密码子优化后的核酸序列


<400>  2
atgcacagcg ctgcaaacgc aaaacaacag aagcacttcg tcctggtcca cggtggttgt        60
ctgggtgctt ggatctggta caaactgaaa cctctgctgg agtctgcagg tcataaagtg       120
actgcagttg atctgagcgc agctggtatc aacccacgtc gtctggatga aattcacact       180
ttccgtgatt acagcgagcc actgatggaa gtgatggcta gcatcccgcc ggatgaaaaa       240
gtggttctgc tgggtcattc tttcggtggt atgtctctgg gtctggctat ggaaacctac       300
ccggagaaaa tctctgttgc tgtgttcatg tccgccatga tgccggatcc gaaccactct       360
ctgacctatc cgtttgaaaa gtacaacgag aagtgcccgg ccgatatgat gctggactct       420
caattctcta cgtacggcaa cccggaaaat ccgggcatgt ctatgatcct gggcccgcag       480
tttatggcgc tgaaaatgtt tcagaactgt agcgtagaag acctggaact ggccaaaatg       540
ctgacccgtc ctggctccct gtttttccag gacctggcga aagcgaaaaa gttcagcacc       600
gaacgttatg gctccgttaa acgcgcgtat attttctgca acgaagacaa aagcttcccg       660
gttgaattcc agaaatggtt cgtagagtcc gttggcgcgg acaaagtaaa agaaatcaaa       720
gaagcggacc acatgggcat gctgtcccag ccgcgcgaag tttgcaaatg cctgctggac       780
atttccgact cctaa                                                        795

