﻿                         序列表

<110>  浙江新码生物医药有限公司

<120>  一种非天然氨基酸及其应用、包含其的重组蛋白以及重组蛋白偶联物

<130>  DSP1P212378J

<160>  7

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  191
<212>  PRT
<213>  智人(Homo sapiens)

<400>  1
Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg 
1               5                   10                  15      
Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu 
            20                  25                  30          
Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro 
        35                  40                  45              
Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg 
    50                  55                  60                  
Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu 
65                  70                  75                  80  
Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val 
                85                  90                  95      
Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp 
            100                 105                 110         
Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu 
        115                 120                 125             
Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser 
    130                 135                 140                 
Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr 
145                 150                 155                 160 
Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe 
                165                 170                 175     
Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe 
            180                 185                 190     

<210>  2
<211>  603
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  2
atgtttccta ctataccact atctcgtcta ttcgataacg ctatgcttcg ggcccatcgt        60
cttcatcagc tggcctttga cacctaccag gagtttgaag aagcctatat cccaaaggaa       120
cagaagtatt cattcctgca gaacccccag acctccctct gtttctcaga gtctattccg       180
acaccctcca acagggagga aacacaacag aaatccaacc tagagctgct ccgcatctcc       240
ctgctgctca tccagtcgtg gctggagccc gtgcagttcc tcaggagtgt cttcgccaac       300
agcctggtgt acggcgcctc ttagagcaac gtctatgacc tcctaaagga cctagaggaa       360
ggcatccaaa cgctgatggg gaggctggaa gatggcagcc cccggactgg gcagatcttc       420
aagcagacct acagcaagtt cgacacaaac tcacacaacg atgacgcact actcaagaac       480
tacgggctgc tctactgctt caggaaggac atggacaagg tcgagacatt cctgcgcatc       540
gtgcagtgcc gctctgtgga gggcagctgt ggcttcctcg agcaccacca ccaccaccac       600
taa                                                                     603

<210>  3
<211>  753
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  3
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac        60
ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctag       120
ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc       180
ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag       240
cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc       300
ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg       360
gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac       420
aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac       480
ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc       540
gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac       600
tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc       660
ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagaag       720
tacgaagatt acaaggatga cgacgataag taa                                    753

<210>  4
<211>  6170
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  4
gttaggcgtt ttgcgctgct tcgcgatgta cgggccagat atacgcgttg acattgatta        60
ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc atatatggag       120
ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc       180
ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga       240
cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat       300
atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc       360
cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt agtcatcgct       420
attaccatgg tgatgcggtt ttggcagtac atcaatgggc gtggatagcg gtttgactca       480
cggggatttc caagtctcca ccccattgac gtcaatggga gtttgttttg gcaccaaaat       540
caacgggact ttccaaaatg tcgtaacaac tccgccccat tgacgcaaat gggcggtagg       600
cgtgtacggt gggaggtcta tataagcaga gctcgtttag tgaaccgtca gatcgcctgg       660
agacgccatc cacgctgttt tgacctccat agaagacacc gggaccgatc cagcctccgg       720
actctagagg atccccgcca ccatggtgag caagggcgag gagctgttca ccggggtggt       780
gcccatcctg gtcgagctgg acggcgacgt aaacggccac aagttcagcg tgtccggcga       840
gggcgagggc gatgccacct agggcaagct gaccctgaag ttcatctgca ccaccggcaa       900
gctgcccgtg ccctggccca ccctcgtgac caccctgacc tacggcgtgc agtgcttcag       960
ccgctacccc gaccacatga agcagcacga cttcttcaag tccgccatgc ccgaaggcta      1020
cgtccaggag cgcaccatct tcttcaagga cgacggcaac tacaagaccc gcgccgaggt      1080
gaagttcgag ggcgacaccc tggtgaaccg catcgagctg aagggcatcg acttcaagga      1140
ggacggcaac atcctggggc acaagctgga gtacaactac aacagccaca acgtctatat      1200
catggccgac aagcagaaga acggcatcaa ggtgaacttc aagatccgcc acaacatcga      1260
ggacggcagc gtgcagctcg ccgaccacta ccagcagaac acccccatcg gcgacggccc      1320
cgtgctgctg cccgacaacc actacctgag cacccagtcc gccctgagca aagaccccaa      1380
cgagaagcgc gatcacatgg tcctgctgga gttcgtgacc gccgccggga tcactctcgg      1440
catggacgag ctgtacaaga agtacgaaga ttacaaggat gacgacgata agtaagaatt      1500
ccggaagggt tcgatcccta ccggttagta atgagtttaa acgggggagg ctaactgaaa      1560
cacggaagga gacaataccg gaaggaaccc gcgctatgac ggcaataaaa agacagaata      1620
aaacgcacgg gtgttgggtc gtttgttcat aaacgcgggg ttcggtccca gggctggcac      1680
tctgtcgata ccccaccgag accccattgg ggccaatacg cccgcgtttc ttccttttcc      1740
ccaccccacc ccccaagttc gggtgaaggc ccagggctcg cagccaacgt cggggcggca      1800
ggccctgcca tagcagatct gcgcagctgg ggctctaggg ggtatcccca cgcgccctgt      1860
agcggcgcat taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc      1920
agcgccctag cgcccgctcc tttcgctttc ttcccttcct ttctcgccac gttcgccggc      1980
tttccccgtc aagctctaaa tcggggcatc cctttagggt tccgatttag tgctttacgg      2040
cacctcgacc ccaaaaaact tgattagggt gatggttcac gtagtgggcc atcgccctga      2100
tagacggttt ttcgcccttt gacgttggag tccacgttct ttaatagtgg actcttgttc      2160
caaactggaa caacactcaa ccctatctcg gtctattctt ttgatttata agggattttg      2220
gggatttcgg cctattggtt aaaaaatgag ctgatttaac aaaaatttaa cgcgaattaa      2280
ttctgtggaa tgtgtgtcag ttagggtgtg gaaagtcccc aggctcccca gcaggcagaa      2340
gtatgcaaag catgcatctc aattagtcag caaccaggtg tggaaagtcc ccaggctccc      2400
cagcaggcag aagtatgcaa agcatgcatc tcaattagtc agcaaccata gtcccgcccc      2460
taactccgcc catcccgccc ctaactccgc ccagttccgc ccattctccg ccccatggct      2520
gactaatttt ttttatttat gcagaggccg aggccgcctc tgcctctgag ctattccaga      2580
agtagtgagg aggctttttt ggaggcctag gcttttgcaa aaagctcccg ggagcttgta      2640
tatccatttt cggatctgat caagagacag gatgaggatc gtttcgcatg attgaacaag      2700
atggattgca cgcaggttct ccggccgctt gggtggagag gctattcggc tatgactggg      2760
cacaacagac aatcggctgc tctgatgccg ccgtgttccg gctgtcagcg caggggcgcc      2820
cggttctttt tgtcaagacc gacctgtccg gtgccctgaa tgaactgcag gacgaggcag      2880
cgcggctatc gtggctggcc acgacgggcg ttccttgcgc agctgtgctc gacgttgtca      2940
ctgaagcggg aagggactgg ctgctattgg gcgaagtgcc ggggcaggat ctcctgtcat      3000
ctcaccttgc tcctgccgag aaagtatcca tcatggctga tgcaatgcgg cggctgcata      3060
cgcttgatcc ggctacctgc ccattcgacc accaagcgaa acatcgcatc gagcgagcac      3120
gtactcggat ggaagccggt cttgtcgatc aggatgatct ggacgaagag catcaggggc      3180
tcgcgccagc cgaactgttc gccaggctca aggcgcgcat gcccgacggc gaggatctcg      3240
tcgtgaccca tggcgatgcc tgcttgccga atatcatggt ggaaaatggc cgcttttctg      3300
gattcatcga ctgtggccgg ctgggtgtgg cggaccgcta tcaggacata gcgttggcta      3360
cccgtgatat tgctgaagag cttggcggcg aatgggctga ccgcttcctc gtgctttacg      3420
gtatcgccgc tcccgattcg cagcgcatcg ccttctatcg ccttcttgac gagttcttct      3480
gagcgggact ctggggttcg cgaaatgacc gaccaagcga cgcccaacct gccatcacga      3540
gatttcgatt ccaccgccgc cttctatgaa aggttgggct tcggaatcgt tttccgggac      3600
gccggctgga tgatcctcca gcgcggggat ctcatgctgg agttcttcgc ccaccccaac      3660
ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat      3720
aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat      3780
catgtctgta taccgtcgac ctctagctag agcttggcgt aatcatggtc atagctgttt      3840
cctgtgtgaa attgttatcc gctcacaatt ccacacaaca tacgagccgg aagcataaag      3900
tgtaaagcct ggggtgccta atgagtgagc taactcacat taattgcgtt gcgctcactg      3960
cccgctttcc agtcgggaaa cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg      4020
gggagaggcg gtttgcgtat tgggcgctct tccgcttcct cgctcactga ctcgctgcgc      4080
tcggtcgttc ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc      4140
acagaatcag gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg      4200
aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat      4260
cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag      4320
gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga      4380
tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcaatgctc acgctgtagg      4440
tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt      4500
cagcccgacc gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac      4560
gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc      4620
ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt      4680
ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc      4740
ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc      4800
agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg      4860
aacgaaaact cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag      4920
atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg      4980
tctgacagtt accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt      5040
tcatccatag ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca      5100
tctggcccca gtgctgcaat gataccgcga gacccacgct caccggctcc agatttatca      5160
gcaataaacc agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc      5220
tccatccagt ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt      5280
ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg      5340
gcttcattca gctccggttc ccaacgatca aggcgagtta catgatcccc catgttgtgc      5400
aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg      5460
ttatcactca tggttatggc agcactgcat aattctctta ctgtcatgcc atccgtaaga      5520
tgcttttctg tgactggtga gtactcaacc aagtcattct gagaatagtg tatgcggcga      5580
ccgagttgct cttgcccggc gtcaatacgg gataataccg cgccacatag cagaacttta      5640
aaagtgctca tcattggaaa acgttcttcg gggcgaaaac tctcaaggat cttaccgctg      5700
ttgagatcca gttcgatgta acccactcgt gcacccaact gatcttcagc atcttttact      5760
ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata      5820
agggcgacac ggaaatgttg aatactcata ctcttccttt ttcaatatta ttgaagcatt      5880
tatcagggtt attgtctcat gagcggatac atatttgaat gtatttagaa aaataaacaa      5940
ataggggttc cgcgcacatt tccccgaaaa gtgccacctg acgtcgacgg atcgggagat      6000
ctcccgatcc cctatggtcg actctcagta caatctgctc tgatgccgca tagttaagcc      6060
agtatctgct ccctgcttgt gtgttggagg tcgctgagta gtgcgcgagc aaaatttaag      6120
ctacaacaag gcaaggcttg accgacaatt gcatgaagaa tctgcttagg                 6170

<210>  5
<211>  450
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  5
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             
Gly Lys 
    450 

<210>  6
<211>  214
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  6
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210>  7
<211>  8071
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  7
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg        60
ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg       120
cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc       180
ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt       240
gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata       300
tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc       360
cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc       420
attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt       480
atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt       540
atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca       600
tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg       660
actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc       720
aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg       780
gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca       840
ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gctggctagc       900
gtttaaactt aagcttatgt accggatgca gctgctgagc tgtatcgccc tgtctctggc       960
cctcgtgacc aacagcgaag tgcagctggt ggaaagcggc ggaggactgg tgcagcctgg      1020
cggatctctg agactgagct gtgccgccag cggcttcaac atcaaggaca cctacatcca      1080
ctgggtgcgc caggcccctg gcaagggact ggaatgggtg gccagaatct accccaccaa      1140
cggctacacc agatacgccg acagcgtgaa gggccggttc accatcagcg ccgacaccag      1200
caagaacacc gcctacctgc agatgaacag cctgcgggcc gaggacaccg ccgtgtacta      1260
ctgtagtaga tggggaggcg acggcttcta cgccatggac tattggggcc agggcaccct      1320
cgtgacagtg tctagtgcgt agaccaaggg gccctcggtc ttccccctgg caccctcctc      1380
caagagcacc tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga      1440
accggtgacg gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc      1500
tgtcctacag tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag      1560
cttgggcacc cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga      1620
caagaaagtt gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc      1680
tgaactcctg gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat      1740
gatctcccgg acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga      1800
ggtcaagttc aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg      1860
ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga      1920
ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat      1980
cgagaaaacc atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc      2040
cccatcccgg gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt      2100
ctatcccagc gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa      2160
gaccacgcct cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt      2220
ggacaagagc aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct      2280
gcacaaccac tacacgcaga agagcctctc cctgtctccc ggcaagtgat aaggccggcc      2340
cctctccctc ccccccccct aacgttactg gccgaagccg cttggaataa ggccggtgtg      2400
cgtttgtcta tatgttattt tccaccatat tgccgtcttt tggcaatgtg agggcccgga      2460
aacctggccc tgtcttcttg acgagcattc ctaggggtct ttcccctctc gccaaaggaa      2520
tgcaaggtct gttgaatgtc gtgaaggaag cagttcctct ggaagcttct tgaagacaaa      2580
caacgtctgt agcgaccctt tgcaggcagc ggaacccccc acctggcgac aggtgcctct      2640
gcggccaaaa gccacgtgta taagatacac ctgcaaaggc ggcacaaccc cagtgccacg      2700
ttgtgagttg gatagttgtg gaaagagtca aatggctctc ctcaagcgta ttcaacaagg      2760
ggctgaagga tgcccagaag gtaccccatt gtatgggatc tgatctgggg cctcggtaca      2820
catgctttac atgtgtttag tcgaggttaa aaaaacgtct aggccccccg aaccacgggg      2880
acgtggtttt cctttgaaaa acacgatgat aatatggcca caaccatgta ccgcatgcaa      2940
ctcctgtctt gcattgcact aagtcttgca cttgtcacaa acagtgatat ccagatgacc      3000
cagagcccca gcagcctgtc tgccagcgtg ggcgacagag tgaccatcac ctgtagagcc      3060
agccaggacg tgaacaccgc cgtggcctgg tatcagcaga agcctggcaa ggcccccaag      3120
ctgctgatct acagcgccag cttcctgtac agcggcgtgc ccagcagatt cagcggcagc      3180
agatccggca ccgacttcac cctgaccatc agctccctgc agcccgagga cttcgccacc      3240
tactactgcc agcagcacta caccaccccc cccacatttg gccagggcac caaggtggaa      3300
atcaagcgta cggtggctgc accatctgtc ttcatcttcc cgccatctga tgagcagttg      3360
aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact tctaccccag agaagccaaa      3420
gtgcagtgga aggtggacaa cgccctgcag agcggaaaca gccaggaaag cgtgacagag      3480
caggattcca aggattccac atacagcctg agcagcacac tgacactgtc caaggccgac      3540
tacgagaagc acaaggtgta cgcctgcgaa gtgacacacc agggactgtc ctcccctgtg      3600
acaaagagct tcaacagagg agaatgctga tgatctagag ggcccgttta aacccgctga      3660
tcagcctcga ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct      3720
tccttgaccc tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca      3780
tcgcattgtc tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag      3840
ggggaggatt gggaagacaa tagcaggcat gctggggatg cggtgggctc tatggcttct      3900
gaggcggaaa gaaccagctg gggctctagg gggtatcccc acgcgccctg tagcggcgca      3960
ttaagcgcgg cgggtgtggt ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta      4020
gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca cgttcgccgg ctttccccgt      4080
caagctctaa atcgggggct ccctttaggg ttccgattta gtgctttacg gcacctcgac      4140
cccaaaaaac ttgattaggg tgatggttca cgtagtgggc catcgccctg atagacggtt      4200
tttcgccctt tgacgttgga gtccacgttc tttaatagtg gactcttgtt ccaaactgga      4260
acaacactca accctatctc ggtctattct tttgatttat aagggatttt gccgatttcg      4320
gcctattggt taaaaaatga gctgatttaa caaaaattta acgcgaatta attctgtgga      4380
atgtgtgtca gttagggtgt ggaaagtccc caggctcccc agcaggcaga agtatgcaaa      4440
gcatgcatct caattagtca gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca      4500
gaagtatgca aagcatgcat ctcaattagt cagcaaccat agtcccgccc ctaactccgc      4560
ccatcccgcc cctaactccg cccagttccg cccattctcc gccccatggc tgactaattt      4620
tttttattta tgcagaggcc gaggccgcct ctgcctctga gctattccag aagtagtgag      4680
gaggcttttt tggaggccta ggcttttgca aaaagctccc gggagcttgt atatccattt      4740
tcggatctga tcaagagaca ggatgaggat cgtttcgcat gattgaacaa gatggattgc      4800
acgcaggttc tccggccgct tgggtggaga ggctattcgg ctatgactgg gcacaacaga      4860
caatcggctg ctctgatgcc gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt      4920
ttgtcaagac cgacctgtcc ggtgccctga atgaactgca ggacgaggca gcgcggctat      4980
cgtggctggc cacgacgggc gttccttgcg cagctgtgct cgacgttgtc actgaagcgg      5040
gaagggactg gctgctattg ggcgaagtgc cggggcagga tctcctgtca tctcaccttg      5100
ctcctgccga gaaagtatcc atcatggctg atgcaatgcg gcggctgcat acgcttgatc      5160
cggctacctg cccattcgac caccaagcga aacatcgcat cgagcgagca cgtactcgga      5220
tggaagccgg tcttgtcgat caggatgatc tggacgaaga gcatcagggg ctcgcgccag      5280
ccgaactgtt cgccaggctc aaggcgcgca tgcccgacgg cgaggatctc gtcgtgaccc      5340
atggcgatgc ctgcttgccg aatatcatgg tggaaaatgg ccgcttttct ggattcatcg      5400
actgtggccg gctgggtgtg gcggaccgct atcaggacat agcgttggct acccgtgata      5460
ttgctgaaga gcttggcggc gaatgggctg accgcttcct cgtgctttac ggtatcgccg      5520
ctcccgattc gcagcgcatc gccttctatc gccttcttga cgagttcttc tgagcgggac      5580
tctggggttc gaaatgaccg accaagcgac gcccaacctg ccatcacgag atttcgattc      5640
caccgccgcc ttctatgaaa ggttgggctt cggaatcgtt ttccgggacg ccggctggat      5700
gatcctccag cgcggggatc tcatgctgga gttcttcgcc caccccaact tgtttattgc      5760
agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt      5820
ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctgtat      5880
accgtcgacc tctagctaga gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa      5940
ttgttatccg ctcacaattc cacacaacat acgagccgga agcataaagt gtaaagcctg      6000
gggtgcctaa tgagtgagct aactcacatt aattgcgttg cgctcactgc ccgctttcca      6060
gtcgggaaac ctgtcgtgcc agctgcatta atgaatcggc caacgcgcgg ggagaggcgg      6120
tttgcgtatt gggcgctctt ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg      6180
gctgcggcga gcggtatcag ctcactcaaa ggcggtaata cggttatcca cagaatcagg      6240
ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa      6300
ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc acaaaaatcg      6360
acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg cgtttccccc      6420
tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat acctgtccgc      6480
ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt atctcagttc      6540
ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc agcccgaccg      6600
ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg acttatcgcc      6660
actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg gtgctacaga      6720
gttcttgaag tggtggccta actacggcta cactagaaga acagtatttg gtatctgcgc      6780
tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg gcaaacaaac      6840
caccgctggt agcggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc      6900
tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg      6960
ttaagggatt ttggtcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta      7020
aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg acagttacca      7080
atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat ccatagttgc      7140
ctgactcccc gtcgtgtaga taactacgat acgggagggc ttaccatctg gccccagtgc      7200
tgcaatgata ccgcgagacc cacgctcacc ggctccagat ttatcagcaa taaaccagcc      7260
agccggaagg gccgagcgca gaagtggtcc tgcaacttta tccgcctcca tccagtctat      7320
taattgttgc cgggaagcta gagtaagtag ttcgccagtt aatagtttgc gcaacgttgt      7380
tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt cattcagctc      7440
cggttcccaa cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa aagcggttag      7500
ctccttcggt cctccgatcg ttgtcagaag taagttggcc gcagtgttat cactcatggt      7560
tatggcagca ctgcataatt ctcttactgt catgccatcc gtaagatgct tttctgtgac      7620
tggtgagtac tcaaccaagt cattctgaga atagtgtatg cggcgaccga gttgctcttg      7680
cccggcgtca atacgggata ataccgcgcc acatagcaga actttaaaag tgctcatcat      7740
tggaaaacgt tcttcggggc gaaaactctc aaggatctta ccgctgttga gatccagttc      7800
gatgtaaccc actcgtgcac ccaactgatc ttcagcatct tttactttca ccagcgtttc      7860
tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg cgacacggaa      7920
atgttgaata ctcatactct tcctttttca atattattga agcatttatc agggttattg      7980
tctcatgagc ggatacatat ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg      8040
cacatttccc cgaaaagtgc cacctgacgt c                                     8071

