                         SEQUENCE LISTING

<110>  Central South University
       CHEN, Xiang
       YIN, Mingzhu
 
<120>  CD147 ANTIBODIES AND CD147-CAR-T CELLS

<130>  144339-8001.WO01

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  385
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr 
1               5                   10                  15      


His Gly Ala Ser Gly Ala Ala Gly Phe Val Gln Ala Pro Leu Ser Gln 
            20                  25                  30          


Gln Arg Trp Val Gly Gly Ser Val Glu Leu His Cys Glu Ala Val Gly 
        35                  40                  45              


Ser Pro Val Pro Glu Ile Gln Trp Trp Phe Glu Gly Gln Gly Pro Asn 
    50                  55                  60                  


Asp Thr Cys Ser Gln Leu Trp Asp Gly Ala Arg Leu Asp Arg Val His 
65                  70                  75                  80  


Ile His Ala Thr Tyr His Gln His Ala Ala Ser Thr Ile Ser Ile Asp 
                85                  90                  95      


Thr Leu Val Glu Glu Asp Thr Gly Thr Tyr Glu Cys Arg Ala Ser Asn 
            100                 105                 110         


Asp Pro Asp Arg Asn His Leu Thr Arg Ala Pro Arg Val Lys Trp Val 
        115                 120                 125             


Arg Ala Gln Ala Val Val Leu Val Leu Glu Pro Gly Thr Val Phe Thr 
    130                 135                 140                 


Thr Val Glu Asp Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn 
145                 150                 155                 160 


Asp Ser Ala Thr Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val 
                165                 170                 175     


Val Leu Lys Glu Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val 
            180                 185                 190         


Asp Ser Asp Asp Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu 
        195                 200                 205             


Pro Met Gly Thr Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys 
    210                 215                 220                 


Ala Val Lys Ser Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu 
225                 230                 235                 240 


Val Cys Lys Ser Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr 
                245                 250                 255     


Lys Ile Thr Asp Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser 
            260                 265                 270         


Arg Phe Phe Val Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu 
        275                 280                 285             


Asn Leu Asn Met Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr 
    290                 295                 300                 


Ser Ser Lys Gly Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser 
305                 310                 315                 320 


His Leu Ala Ala Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu 
                325                 330                 335     


Val Leu Val Thr Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu 
            340                 345                 350         


Asp Val Leu Asp Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser 
        355                 360                 365             


Gly Gln His Gln Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser 
    370                 375                 380                 


Ser 
385 


<210>  2
<211>  720
<212>  DNA
<213>  Mus musculus

<400>  2
gtgcagtttc aagaaagcgg ccccggcctg gttaagccgt cacagtctct tagcctcacg       60

tgcacagtta ccggatactc cataacgtct gattacgcat ggaactggat tcgacaattt      120

cccggcaacc aacttgaatg gcttggatat ataacgtatt ctggtacaat agggtacaat      180

ccgtccctcc gctctaggat ttcagttacc agagatactt caaaaaacca gatattcttg      240

cacctgaact ccgttactac tgacgacact gcaacgtatt attgtgtacg atggacatgg      300

gacctgggaa cattcgcgtc ctgggggcaa ggaacgctcg ttacagttag tgccggtggg      360

ggtggatcag gtggaggagg atcaggcggc ggcggatctc aaattgtact tacccaaagt      420

cctgcaatta tgtctgcatc tccgggagag aaggtaacta tttcatgttc tgcaagtagc      480

tctgttagtt atatgtattg gtaccagcaa aaaccaggaa gctcccccaa accatggata      540

tatcggacca gtaacctggc aagtggcgta cctgctaggt tttccgggag tggttccggg      600

acaagctata gtctgacaat ttcttccatg gaagccgagg acgccgcgac ttattattgt      660

cagcagtacc acagctatcc attgactttt ggagccggaa cgaaacttga actgaaacgg      720


<210>  3
<211>  240
<212>  PRT
<213>  Mus musculus

<400>  3

Val Gln Phe Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Ser 
1               5                   10                  15      


Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp Tyr 
            20                  25                  30          


Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Gln Leu Glu Trp Leu 
        35                  40                  45              


Gly Tyr Ile Thr Tyr Ser Gly Thr Ile Gly Tyr Asn Pro Ser Leu Arg 
    50                  55                  60                  


Ser Arg Ile Ser Val Thr Arg Asp Thr Ser Lys Asn Gln Ile Phe Leu 
65                  70                  75                  80  


His Leu Asn Ser Val Thr Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Val 
                85                  90                  95      


Arg Trp Thr Trp Asp Leu Gly Thr Phe Ala Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met 
    130                 135                 140                 


Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Ser Cys Ser Ala Ser Ser 
145                 150                 155                 160 


Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro 
                165                 170                 175     


Lys Pro Trp Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
        195                 200                 205             


Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr His 
    210                 215                 220                 


Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
225                 230                 235                 240 


<210>  4
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  4

Val Gln Phe Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Ser 
1               5                   10                  15      


Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp Tyr 
            20                  25                  30          


Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Gln Leu Glu Trp Leu 
        35                  40                  45              


Gly Tyr Ile Thr Tyr Ser Gly Thr Ile Gly Tyr Asn Pro Ser Leu Arg 
    50                  55                  60                  


Ser Arg Ile Ser Val Thr Arg Asp Thr Ser Lys Asn Gln Ile Phe Leu 
65                  70                  75                  80  


His Leu Asn Ser Val Thr Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Val 
                85                  90                  95      


Arg Trp Thr Trp Asp Leu Gly Thr Phe Ala Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  5
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  5

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105         


<210>  6
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  7
<211>  717
<212>  DNA
<213>  Mus musculus

<400>  7
gaagtgaagc tcgaagaatc tgggggtggg ttggtgcaac cggggggttc catgaagctg       60

agttgcgtcg cctcagggtt cacttttagc aacttttgga tgaactgggt gcggcagtca      120

cctgagaagg ggctggagtg ggtcgccgag attcgattga aatctaccaa ttacgcgacg      180

cattatgccg atagcgtaaa gggccgcttc acgataagtc gggatgattc caaaagctct      240

gtctatctcc agatgaataa cctcagggcg gaagacacgg gaatctatta ctgcactgga      300

accggcacta attattgggg tcagggtacg acgcttaccg tctcttcagg aggtggcggg      360

tctggtgggg gtgggtcagg cggaggaggc agcgatatca aaatgaccca gtcaccaagt      420

tcaatgtacg ccagcttggg cgagcgagtc acaattacct gcaaagcctc tcaagacata      480

aattcttatc tttcatggtt tcagcaaaag cctgggaaga gcccgaaaac tctcatatac      540

cgcgcaaaca gattggttga tggcgtacct tcacgcttta gtggaagcgg ctccgggcag      600

gattattctt tgacgatttc cagcctggag tacgaggata tgggcatcta ctattgcctg      660

cagtatgacg aatttccata cacatttggt gggggaacta aactggaaat caaacgg         717


<210>  8
<211>  239
<212>  PRT
<213>  Mus musculus

<400>  8

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Leu Lys Ser Thr Asn Tyr Ala Thr His Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Gly Thr Gly Thr Asn Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala 
    130                 135                 140                 


Ser Leu Gly Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
145                 150                 155                 160 


Asn Ser Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys 
                165                 170                 175     


Thr Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg 
            180                 185                 190         


Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser 
        195                 200                 205             


Leu Glu Tyr Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu 
    210                 215                 220                 


Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
225                 230                 235                 


<210>  9
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  9

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Leu Lys Ser Thr Asn Tyr Ala Thr His Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Gly Thr Gly Thr Asn Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  10
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  10

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  11
<211>  69
<212>  DNA
<213>  Homo sapiens

<400>  11
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggctagc                                                               69


<210>  12
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Ser 
            20              


<210>  13
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  13

Ala Cys Cys Ala Cys Gly Ala Cys Gly Cys Cys Ala Gly Cys Gly Cys 
1               5                   10                  15      


Cys Gly Cys Gly Ala Cys Cys Ala Cys Cys Ala Ala Cys Ala Cys Cys 
            20                  25                  30          


Gly Gly Cys Gly Cys Cys Cys Ala Cys Cys Ala Thr Cys Gly Cys Gly 
        35                  40                  45              


Thr Cys Gly Cys Ala Gly Cys Cys Cys Cys Thr Gly Thr Cys Cys Cys 
    50                  55                  60                  


Thr Gly Cys Gly Cys Cys Cys Ala Gly Ala Gly Gly Cys Gly Ala Gly 
65                  70                  75                  80  


Cys Cys Gly Gly Cys Cys Ala Gly Cys Gly Gly Cys Gly Gly Gly Gly 
                85                  90                  95      


Gly Gly Cys Gly Cys Ala Gly Thr Gly Cys Ala Cys Ala Cys Gly Ala 
            100                 105                 110         


Gly Gly Gly Gly Gly Cys Thr Gly Gly Ala Cys Thr Thr Cys Gly Cys 
        115                 120                 125             


Cys Ala Gly Thr Gly Ala Thr 
    130                 135 


<210>  14
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  14

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp 
        35                  40                  45  


<210>  15
<211>  81
<212>  DNA
<213>  Homo sapiens

<400>  15
ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg       60

gcctttatta ttttctgggt g                                                 81


<210>  16
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  16

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  17
<211>  126
<212>  DNA
<213>  Homo sapiens

<400>  17
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  18
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  18

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  19
<211>  342
<212>  DNA
<213>  Homo sapiens

<400>  19
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgcag agaaggaaga accctcagga aggcctctac      180

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag      240

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac      300

acctacgacg cccttcacat gcaggccctg ccccctcgct aa                         342


<210>  20
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  20

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  21
<211>  1491
<212>  DNA
<213>  Mus musculus

<400>  21
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggctagcg tgcagtttca agaaagcggc cccggcctgg ttaagccgtc acagtctctt      120

agcctcacgt gcacagttac cggatactcc ataacgtctg attacgcatg gaactggatt      180

cgacaatttc ccggcaacca acttgaatgg cttggatata taacgtattc tggtacaata      240

gggtacaatc cgtccctccg ctctaggatt tcagttacca gagatacttc aaaaaaccag      300

atattcttgc acctgaactc cgttactact gacgacactg caacgtatta ttgtgtacga      360

tggacatggg acctgggaac attcgcgtcc tgggggcaag gaacgctcgt tacagttagt      420

gccggtgggg gtggatcagg tggaggagga tcaggcggcg gcggatctca aattgtactt      480

acccaaagtc ctgcaattat gtctgcatct ccgggagaga aggtaactat ttcatgttct      540

gcaagtagct ctgttagtta tatgtattgg taccagcaaa aaccaggaag ctcccccaaa      600

ccatggatat atcggaccag taacctggca agtggcgtac ctgctaggtt ttccgggagt      660

ggttccggga caagctatag tctgacaatt tcttccatgg aagccgagga cgccgcgact      720

tattattgtc agcagtacca cagctatcca ttgacttttg gagccggaac gaaacttgaa      780

ctgaaacggc tcgagaagcc caccacgacg ccagcgccgc gaccaccaac accggcgccc      840

accatcgcgt cgcagcccct gtccctgcgc ccagaggcga gccggccagc ggcggggggc      900

gcagtgcaca cgagggggct ggacttcgcc agtgataagc ccttttgggt gctggtggtg      960

gttggtggag tcctggcttg ctatagcttg ctagtaacag tggcctttat tattttctgg     1020

gtgaaacggg gcagaaagaa actcctgtat atattcaaac aaccatttat gagaccagta     1080

caaactactc aagaggaaga tggctgtagc tgccgatttc cagaagaaga agaaggagga     1140

tgtgaactga gagtgaagtt cagcaggagc gcagacgccc ccgcgtacca gcagggccag     1200

aaccagctct ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag     1260

agacgtggcc gggaccctga gatgggggga aagccgcaga gaaggaagaa ccctcaggaa     1320

ggcctctaca atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg     1380

aaaggcgagc gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc     1440

accaaggaca cctacgacgc ccttcacatg caggccctgc cccctcgcta a              1491


<210>  22
<211>  496
<212>  PRT
<213>  Mus musculus

<400>  22

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Ser Val Gln Phe Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Gly 
        35                  40                  45              


Tyr Ser Ile Thr Ser Asp Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro 
    50                  55                  60                  


Gly Asn Gln Leu Glu Trp Leu Gly Tyr Ile Thr Tyr Ser Gly Thr Ile 
65                  70                  75                  80  


Gly Tyr Asn Pro Ser Leu Arg Ser Arg Ile Ser Val Thr Arg Asp Thr 
                85                  90                  95      


Ser Lys Asn Gln Ile Phe Leu His Leu Asn Ser Val Thr Thr Asp Asp 
            100                 105                 110         


Thr Ala Thr Tyr Tyr Cys Val Arg Trp Thr Trp Asp Leu Gly Thr Phe 
        115                 120                 125             


Ala Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu 
145                 150                 155                 160 


Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr 
                165                 170                 175     


Ile Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Arg Thr Ser Asn 
        195                 200                 205             


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Leu Thr Phe Gly Ala Gly 
                245                 250                 255     


Thr Lys Leu Glu Leu Lys Arg Leu Glu Lys Pro Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Ser Asp Lys Pro Phe Trp Val Leu Val Val 
305                 310                 315                 320 


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
                325                 330                 335     


Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            340                 345                 350         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        355                 360                 365             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
        435                 440                 445             


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
    450                 455                 460                 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
465                 470                 475                 480 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495     


<210>  23
<211>  1488
<212>  DNA
<213>  Mus musculus

<400>  23
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggctagcg aagtgaagct cgaagaatct gggggtgggt tggtgcaacc ggggggttcc      120

atgaagctga gttgcgtcgc ctcagggttc acttttagca acttttggat gaactgggtg      180

cggcagtcac ctgagaaggg gctggagtgg gtcgccgaga ttcgattgaa atctaccaat      240

tacgcgacgc attatgccga tagcgtaaag ggccgcttca cgataagtcg ggatgattcc      300

aaaagctctg tctatctcca gatgaataac ctcagggcgg aagacacggg aatctattac      360

tgcactggaa ccggcactaa ttattggggt cagggtacga cgcttaccgt ctcttcagga      420

ggtggcgggt ctggtggggg tgggtcaggc ggaggaggca gcgatatcaa aatgacccag      480

tcaccaagtt caatgtacgc cagcttgggc gagcgagtca caattacctg caaagcctct      540

caagacataa attcttatct ttcatggttt cagcaaaagc ctgggaagag cccgaaaact      600

ctcatatacc gcgcaaacag attggttgat ggcgtacctt cacgctttag tggaagcggc      660

tccgggcagg attattcttt gacgatttcc agcctggagt acgaggatat gggcatctac      720

tattgcctgc agtatgacga atttccatac acatttggtg ggggaactaa actggaaatc      780

aaacggctcg agaagcccac cacgacgcca gcgccgcgac caccaacacc ggcgcccacc      840

atcgcgtcgc agcccctgtc cctgcgccca gaggcgagcc ggccagcggc ggggggcgca      900

gtgcacacga gggggctgga cttcgccagt gataagccct tttgggtgct ggtggtggtt      960

ggtggagtcc tggcttgcta tagcttgcta gtaacagtgg cctttattat tttctgggtg     1020

aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa     1080

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt     1140

gaactgagag tgaagttcag caggagcgca gacgcccccg cgtaccagca gggccagaac     1200

cagctctata acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagaga     1260

cgtggccggg accctgagat ggggggaaag ccgcagagaa ggaagaaccc tcaggaaggc     1320

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     1380

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc     1440

aaggacacct acgacgccct tcacatgcag gccctgcccc ctcgctaa                  1488


<210>  24
<211>  495
<212>  PRT
<213>  Mus musculus

<400>  24

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Ser Glu Val Lys Leu Glu Glu Ser Gly Gly 
            20                  25                  30          


Gly Leu Val Gln Pro Gly Gly Ser Met Lys Leu Ser Cys Val Ala Ser 
        35                  40                  45              


Gly Phe Thr Phe Ser Asn Phe Trp Met Asn Trp Val Arg Gln Ser Pro 
    50                  55                  60                  


Glu Lys Gly Leu Glu Trp Val Ala Glu Ile Arg Leu Lys Ser Thr Asn 
65                  70                  75                  80  


Tyr Ala Thr His Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                85                  90                  95      


Arg Asp Asp Ser Lys Ser Ser Val Tyr Leu Gln Met Asn Asn Leu Arg 
            100                 105                 110         


Ala Glu Asp Thr Gly Ile Tyr Tyr Cys Thr Gly Thr Gly Thr Asn Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Lys Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly Glu Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr Leu Ser Trp Phe Gln Gln 
            180                 185                 190         


Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu 
        195                 200                 205             


Val Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp 
    210                 215                 220                 


Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr Glu Asp Met Gly Ile Tyr 
225                 230                 235                 240 


Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr Thr Phe Gly Gly Gly Thr 
                245                 250                 255     


Lys Leu Glu Ile Lys Arg Leu Glu Lys Pro Thr Thr Thr Pro Ala Pro 
            260                 265                 270         


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
        275                 280                 285             


Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
    290                 295                 300                 


Gly Leu Asp Phe Ala Ser Asp Lys Pro Phe Trp Val Leu Val Val Val 
305                 310                 315                 320 


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
                325                 330                 335     


Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
            340                 345                 350         


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
        355                 360                 365             


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
    370                 375                 380                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
385                 390                 395                 400 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                405                 410                 415     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210>  25
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  25

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Thr Tyr Ser Gly Thr Ile Gly Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Arg Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Thr Trp Asp Leu Gly Thr Phe Ala Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  26
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  26

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Tyr Ile Thr Tyr Ser Gly Thr Ile Gly Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Arg Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Trp Thr Trp Asp Leu Gly Thr Phe Ala Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  27
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  27

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Thr Tyr Ser Gly Thr Ile Gly Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Arg Ser Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Thr Trp Asp Leu Gly Thr Phe Ala Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  28
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  28

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Arg Thr Ser Asn Leu Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  29
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  29

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  30
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  30

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


