                         SEQUENCE LISTING

<110>  Monsanto Technology LLC
 
<120>  NOVEL INSECT INHIBITORY PROTEINS

<130>  MONS:530WO

<150>  US 63/219,604
<151>  2021-07-08

<150>  US 63/348,278
<151>  2022-06-02

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  2160
<212>  DNA
<213>  Bacillus thuringiensis


<220>
<221>  misc_feature
<222>  (1)..(2160)
<223>  Nucleic acid sequence encoding a TIC2199 pesticidal protein 
       obtained from Bacillus thuringiensis species EG8639.

<400>  1
atgaaaccaa agaatcaaaa tatgtatcaa agcttgtcta gcaatgtgac agttgataaa       60

atctctacaa atccactaaa aaatgaaaca gatatagaat tacaaaatat taatcatgaa      120

gcttgtttaa aaatgtctaa gtataaaaat gtagcgccat ttgttagcgc atcaacaatt      180

caaacgggga ttggaattgc tggtaagatt cttggtactc taggtgttcc ttttgctgga      240

caaatagcta gcctctatag ttttatctta ggcgagcttt ggcctaaagg gaaaagtcaa      300

tgggaaatct ttatggaaca tgtagaagag attattaatc aaaaaatatc aacttatgca      360

agaaataaag ctctttcaga cttgagagga ttaggggatg ctttagccgt ctaccatgaa      420

tcgcttgaaa gttgggttga aaatcgtaat aacactcgag cgaggagtgt agtcaagaac      480

caatatatcg cattagaact gatgtttgtt caaaaactac cttcttttgc agtatctggt      540

gaggaagtac cattattacc gatatacgcc caagctgcca atttacattt gttgttatta      600

agagatgtat ctatttttgg aaaagaatgg ggattatcag cttcagaaat ttcaacattt      660

tataaccgtc aagtcgaacg aacaagagat tattccgacc attgtgtaaa atggtataat      720

acaggcctaa ataacttgag gggtacaaat gccaaaagtt gggttcgtta taatcaattt      780

cgtaaagata tgacattaat ggtattagat ttagttgcgc tattcccaag ctatgataca      840

cttgtatatc ctattaaaac cacttcacaa cttacaagag aagtatatac agacgcaatt      900

gggaccgtgc atccgaatca agcttttgca agtacgactt ggtataataa taatgcacct      960

tcgttctctg ccatagaggc tgctgttatc cgaagtccac acctacttga ttttctagaa     1020

aaagttacaa tatacagctt attaagtcgg tggagtaata ctcagtatat gaatatgtgg     1080

ggaggacata gacttgaatc ccgcccaata ggaggggcat taaatacctc aacacaagga     1140

tctaccaata cttcgattaa tccagtaaca ttacagttca cgtctcgaga cgtttatagg     1200

actgaatcat gggcagggct gaatttattt ttaactcaac ctgttaatgg agtacctaga     1260

gttgatttcc attggaaatt cgtcacacat ccgatcgcat ctgataattt ctattatcca     1320

gggtatgctg gaattgggac acaattacaa gattcagaaa atgaattacc acctgaaaca     1380

acaggacagc caaattatga atcatatagt catagattat ctcatatagg actcatttca     1440

gcatcacatg tgaaagcatt ggtatattct tggacgcatc gtagtgcaga tcgtacaaat     1500

acaattgagc caaatagcat tacacaaata ccattagtaa aagcgttcaa tctttcttca     1560

ggtgccgctg ttgtgagagg accaggattt acaggtgggg atatccttcg aagaacgaat     1620

actggtacat ttggggatat acgagtaaat attaatccac catttgcaca aaggtatcgc     1680

gtaaggattc gctatgcttc tactacagat ttacaattcc atacgtcaat taacggtaaa     1740

gctattaatc aaggtaattt ttcagcaact atgaatagag gagaggactt agactataaa     1800

acctttagaa ctgtaggctt taccactcca tttagctttt cagatgtaca aagtacattc     1860

acaataggtg cttggaactt ctcttcaggt aacgaagttt atatagatag aattgaattt     1920

gttccggtag aagttacata tggggcagaa tatgattttg aaaaagcgca agagaaggtt     1980

actgcactgt ttacatctac gaatccaaga gaattaaaaa tagatgtaac ggattatcat     2040

attgaccagg tatcaaattt agtagagtct ctattagacg aattctatct tgatgaaaag     2100

agagaattat tcgagatagt taaatacgcg aagcaactct atattgagcg taacatgtag     2160


<210>  2
<211>  719
<212>  PRT
<213>  Bacillus thuringiensis


<220>
<221>  MISC_FEATURE
<222>  (1)..(719)
<223>  Amino acid sequence of the TIC2199 pesticidal protein.

<400>  2

Met Lys Pro Lys Asn Gln Asn Met Tyr Gln Ser Leu Ser Ser Asn Val 
1               5                   10                  15      


Thr Val Asp Lys Ile Ser Thr Asn Pro Leu Lys Asn Glu Thr Asp Ile 
            20                  25                  30          


Glu Leu Gln Asn Ile Asn His Glu Ala Cys Leu Lys Met Ser Lys Tyr 
        35                  40                  45              


Lys Asn Val Ala Pro Phe Val Ser Ala Ser Thr Ile Gln Thr Gly Ile 
    50                  55                  60                  


Gly Ile Ala Gly Lys Ile Leu Gly Thr Leu Gly Val Pro Phe Ala Gly 
65                  70                  75                  80  


Gln Ile Ala Ser Leu Tyr Ser Phe Ile Leu Gly Glu Leu Trp Pro Lys 
                85                  90                  95      


Gly Lys Ser Gln Trp Glu Ile Phe Met Glu His Val Glu Glu Ile Ile 
            100                 105                 110         


Asn Gln Lys Ile Ser Thr Tyr Ala Arg Asn Lys Ala Leu Ser Asp Leu 
        115                 120                 125             


Arg Gly Leu Gly Asp Ala Leu Ala Val Tyr His Glu Ser Leu Glu Ser 
    130                 135                 140                 


Trp Val Glu Asn Arg Asn Asn Thr Arg Ala Arg Ser Val Val Lys Asn 
145                 150                 155                 160 


Gln Tyr Ile Ala Leu Glu Leu Met Phe Val Gln Lys Leu Pro Ser Phe 
                165                 170                 175     


Ala Val Ser Gly Glu Glu Val Pro Leu Leu Pro Ile Tyr Ala Gln Ala 
            180                 185                 190         


Ala Asn Leu His Leu Leu Leu Leu Arg Asp Val Ser Ile Phe Gly Lys 
        195                 200                 205             


Glu Trp Gly Leu Ser Ala Ser Glu Ile Ser Thr Phe Tyr Asn Arg Gln 
    210                 215                 220                 


Val Glu Arg Thr Arg Asp Tyr Ser Asp His Cys Val Lys Trp Tyr Asn 
225                 230                 235                 240 


Thr Gly Leu Asn Asn Leu Arg Gly Thr Asn Ala Lys Ser Trp Val Arg 
                245                 250                 255     


Tyr Asn Gln Phe Arg Lys Asp Met Thr Leu Met Val Leu Asp Leu Val 
            260                 265                 270         


Ala Leu Phe Pro Ser Tyr Asp Thr Leu Val Tyr Pro Ile Lys Thr Thr 
        275                 280                 285             


Ser Gln Leu Thr Arg Glu Val Tyr Thr Asp Ala Ile Gly Thr Val His 
    290                 295                 300                 


Pro Asn Gln Ala Phe Ala Ser Thr Thr Trp Tyr Asn Asn Asn Ala Pro 
305                 310                 315                 320 


Ser Phe Ser Ala Ile Glu Ala Ala Val Ile Arg Ser Pro His Leu Leu 
                325                 330                 335     


Asp Phe Leu Glu Lys Val Thr Ile Tyr Ser Leu Leu Ser Arg Trp Ser 
            340                 345                 350         


Asn Thr Gln Tyr Met Asn Met Trp Gly Gly His Arg Leu Glu Ser Arg 
        355                 360                 365             


Pro Ile Gly Gly Ala Leu Asn Thr Ser Thr Gln Gly Ser Thr Asn Thr 
    370                 375                 380                 


Ser Ile Asn Pro Val Thr Leu Gln Phe Thr Ser Arg Asp Val Tyr Arg 
385                 390                 395                 400 


Thr Glu Ser Trp Ala Gly Leu Asn Leu Phe Leu Thr Gln Pro Val Asn 
                405                 410                 415     


Gly Val Pro Arg Val Asp Phe His Trp Lys Phe Val Thr His Pro Ile 
            420                 425                 430         


Ala Ser Asp Asn Phe Tyr Tyr Pro Gly Tyr Ala Gly Ile Gly Thr Gln 
        435                 440                 445             


Leu Gln Asp Ser Glu Asn Glu Leu Pro Pro Glu Thr Thr Gly Gln Pro 
    450                 455                 460                 


Asn Tyr Glu Ser Tyr Ser His Arg Leu Ser His Ile Gly Leu Ile Ser 
465                 470                 475                 480 


Ala Ser His Val Lys Ala Leu Val Tyr Ser Trp Thr His Arg Ser Ala 
                485                 490                 495     


Asp Arg Thr Asn Thr Ile Glu Pro Asn Ser Ile Thr Gln Ile Pro Leu 
            500                 505                 510         


Val Lys Ala Phe Asn Leu Ser Ser Gly Ala Ala Val Val Arg Gly Pro 
        515                 520                 525             


Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Thr Asn Thr Gly Thr Phe 
    530                 535                 540                 


Gly Asp Ile Arg Val Asn Ile Asn Pro Pro Phe Ala Gln Arg Tyr Arg 
545                 550                 555                 560 


Val Arg Ile Arg Tyr Ala Ser Thr Thr Asp Leu Gln Phe His Thr Ser 
                565                 570                 575     


Ile Asn Gly Lys Ala Ile Asn Gln Gly Asn Phe Ser Ala Thr Met Asn 
            580                 585                 590         


Arg Gly Glu Asp Leu Asp Tyr Lys Thr Phe Arg Thr Val Gly Phe Thr 
        595                 600                 605             


Thr Pro Phe Ser Phe Ser Asp Val Gln Ser Thr Phe Thr Ile Gly Ala 
    610                 615                 620                 


Trp Asn Phe Ser Ser Gly Asn Glu Val Tyr Ile Asp Arg Ile Glu Phe 
625                 630                 635                 640 


Val Pro Val Glu Val Thr Tyr Gly Ala Glu Tyr Asp Phe Glu Lys Ala 
                645                 650                 655     


Gln Glu Lys Val Thr Ala Leu Phe Thr Ser Thr Asn Pro Arg Glu Leu 
            660                 665                 670         


Lys Ile Asp Val Thr Asp Tyr His Ile Asp Gln Val Ser Asn Leu Val 
        675                 680                 685             


Glu Ser Leu Leu Asp Glu Phe Tyr Leu Asp Glu Lys Arg Glu Leu Phe 
    690                 695                 700                 


Glu Ile Val Lys Tyr Ala Lys Gln Leu Tyr Ile Glu Arg Asn Met 
705                 710                 715                 


<210>  3
<211>  2160
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic coding sequence used for expression in a plant cell 
       encoding TIC2199.

<400>  3
atgaagccca agaatcagaa catgtaccag tccctcagct cgaacgtcac cgtcgataag       60

attagcacca acccgctcaa gaatgagacc gacatcgaat tacagaacat taaccacgag      120

gcgtgcctca agatgtctaa gtacaagaac gtcgcaccct tcgtctcggc ttctacgatc      180

cagacgggca ttggcatcgc cgggaagata ctcggcacac tcggcgtccc gttcgctggt      240

caaatcgcct cgctctactc cttcatactc ggtgaactgt ggccgaaggg caagtcgcag      300

tgggaaatct tcatggagca cgtggaggag atcatcaacc agaagataag cacctacgcc      360

cgtaacaagg cgctgagcga cctccgtggg ctgggcgatg cgctggcggt gtaccacgag      420

tcgctggagt cgtgggtgga gaaccgcaac aacacccgcg cccggtccgt ggtcaagaac      480

cagtacattg ccctggagct gatgttcgtg cagaagctcc cgtccttcgc ggtgtccggc      540

gaggaagtgc cactgttgcc catctacgcc caagcagcca acctgcacct ccttctcctc      600

cgggacgtca gcatcttcgg gaaggagtgg ggcctttcag cgtcagagat ttcaaccttc      660

tacaacaggc aagttgagcg cacgcgcgac tactcggacc actgcgtcaa gtggtacaac      720

accggcctca acaacctgcg tggaacgaac gccaagagct gggtccgcta caaccagttt      780

cgaaaggaca tgaccctcat ggtgctggac cttgtggcct tgttcccgtc ctacgacacc      840

ctcgtttatc cgattaagac tacatctcaa cttacccgcg aggtttacac agacgccata      900

gggaccgtgc atcctaacca ggcgttcgca tcgacaactt ggtacaacaa caacgcgccc      960

tcgttctcag ccatcgaggc cgccgtgatc cgttcaccgc acctcctgga cttcctggag     1020

aaggttacca tctactccct cttgtctcgc tggagtaata ctcagtacat gaacatgtgg     1080

ggaggacatc gcctcgaatc tcgaccgatt ggcggcgcgc ttaacacatc cacacagggc     1140

tccacgaaca ccagcatcaa cccggtgacg ttgcaattca cttcacgcga tgtctatcgg     1200

accgagagct gggctggcct gaacctgttc ctaactcagc ccgtgaacgg tgtgcccaga     1260

gtcgatttcc actggaaatt cgtcactcat cccatcgcca gcgacaactt ctactaccca     1320

ggctacgccg gtatcggcac acagcttcaa gactccgaga acgaactgcc tcccgagact     1380

actggccagc cgaactacga gagttactcc cataggcttt cgcacatcgg cctaatctca     1440

gcttcgcatg ttaaagcact cgtgtactca tggacacaca gaagcgccga cagaacgaac     1500

accattgagc caaactctat cacgcagatc ccgctggtta aggcgttcaa cttgtcgagc     1560

ggcgctgcgg tcgtgcgcgg acctggattc accggtggcg acattctgcg ccgcaccaac     1620

acaggaacct tcggcgacat ccgggtgaac atcaacccgc cgtttgcaca acgctatcgc     1680

gtcaggatac ggtacgcatc cacgacggac ctccagttcc acaccagcat caacgggaag     1740

gctatcaacc agggaaactt tagcgccacg atgaaccgtg gtgaggactt ggactacaag     1800

acattccgga cggtcggctt cacgacgccc ttcagcttta gcgacgtcca gtccaccttc     1860

accatcggag catggaactt cagtagcggc aacgaggtgt acatcgaccg aatcgagttc     1920

gtcccggttg aggtgaccta cggagccgaa tacgacttcg agaaggcaca ggagaaggtg     1980

actgctctgt ttacaagcac aaatcctcgg gaactaaaga tcgacgtcac agactaccac     2040

atcgaccaag ttagcaacct cgtcgagagc ctcctggacg agttctattt ggacgagaag     2100

cgggagctgt tcgagatcgt gaaatacgcc aagcagttgt acatcgagcg taacatgtga     2160


<210>  4
<211>  611
<212>  PRT
<213>  Bacillus thuringiensis


<220>
<221>  MISC_FEATURE
<222>  (1)..(611)
<223>  An amino acid sequence of a fragment of TIC2199 wherein the 
       N-terminal signal peptide and protoxin domain has been removed.

<400>  4

Met Ser Lys Tyr Lys Asn Val Ala Pro Phe Val Ser Ala Ser Thr Ile 
1               5                   10                  15      


Gln Thr Gly Ile Gly Ile Ala Gly Lys Ile Leu Gly Thr Leu Gly Val 
            20                  25                  30          


Pro Phe Ala Gly Gln Ile Ala Ser Leu Tyr Ser Phe Ile Leu Gly Glu 
        35                  40                  45              


Leu Trp Pro Lys Gly Lys Ser Gln Trp Glu Ile Phe Met Glu His Val 
    50                  55                  60                  


Glu Glu Ile Ile Asn Gln Lys Ile Ser Thr Tyr Ala Arg Asn Lys Ala 
65                  70                  75                  80  


Leu Ser Asp Leu Arg Gly Leu Gly Asp Ala Leu Ala Val Tyr His Glu 
                85                  90                  95      


Ser Leu Glu Ser Trp Val Glu Asn Arg Asn Asn Thr Arg Ala Arg Ser 
            100                 105                 110         


Val Val Lys Asn Gln Tyr Ile Ala Leu Glu Leu Met Phe Val Gln Lys 
        115                 120                 125             


Leu Pro Ser Phe Ala Val Ser Gly Glu Glu Val Pro Leu Leu Pro Ile 
    130                 135                 140                 


Tyr Ala Gln Ala Ala Asn Leu His Leu Leu Leu Leu Arg Asp Val Ser 
145                 150                 155                 160 


Ile Phe Gly Lys Glu Trp Gly Leu Ser Ala Ser Glu Ile Ser Thr Phe 
                165                 170                 175     


Tyr Asn Arg Gln Val Glu Arg Thr Arg Asp Tyr Ser Asp His Cys Val 
            180                 185                 190         


Lys Trp Tyr Asn Thr Gly Leu Asn Asn Leu Arg Gly Thr Asn Ala Lys 
        195                 200                 205             


Ser Trp Val Arg Tyr Asn Gln Phe Arg Lys Asp Met Thr Leu Met Val 
    210                 215                 220                 


Leu Asp Leu Val Ala Leu Phe Pro Ser Tyr Asp Thr Leu Val Tyr Pro 
225                 230                 235                 240 


Ile Lys Thr Thr Ser Gln Leu Thr Arg Glu Val Tyr Thr Asp Ala Ile 
                245                 250                 255     


Gly Thr Val His Pro Asn Gln Ala Phe Ala Ser Thr Thr Trp Tyr Asn 
            260                 265                 270         


Asn Asn Ala Pro Ser Phe Ser Ala Ile Glu Ala Ala Val Ile Arg Ser 
        275                 280                 285             


Pro His Leu Leu Asp Phe Leu Glu Lys Val Thr Ile Tyr Ser Leu Leu 
    290                 295                 300                 


Ser Arg Trp Ser Asn Thr Gln Tyr Met Asn Met Trp Gly Gly His Arg 
305                 310                 315                 320 


Leu Glu Ser Arg Pro Ile Gly Gly Ala Leu Asn Thr Ser Thr Gln Gly 
                325                 330                 335     


Ser Thr Asn Thr Ser Ile Asn Pro Val Thr Leu Gln Phe Thr Ser Arg 
            340                 345                 350         


Asp Val Tyr Arg Thr Glu Ser Trp Ala Gly Leu Asn Leu Phe Leu Thr 
        355                 360                 365             


Gln Pro Val Asn Gly Val Pro Arg Val Asp Phe His Trp Lys Phe Val 
    370                 375                 380                 


Thr His Pro Ile Ala Ser Asp Asn Phe Tyr Tyr Pro Gly Tyr Ala Gly 
385                 390                 395                 400 


Ile Gly Thr Gln Leu Gln Asp Ser Glu Asn Glu Leu Pro Pro Glu Thr 
                405                 410                 415     


Thr Gly Gln Pro Asn Tyr Glu Ser Tyr Ser His Arg Leu Ser His Ile 
            420                 425                 430         


Gly Leu Ile Ser Ala Ser His Val Lys Ala Leu Val Tyr Ser Trp Thr 
        435                 440                 445             


His Arg Ser Ala Asp Arg Thr Asn Thr Ile Glu Pro Asn Ser Ile Thr 
    450                 455                 460                 


Gln Ile Pro Leu Val Lys Ala Phe Asn Leu Ser Ser Gly Ala Ala Val 
465                 470                 475                 480 


Val Arg Gly Pro Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Thr Asn 
                485                 490                 495     


Thr Gly Thr Phe Gly Asp Ile Arg Val Asn Ile Asn Pro Pro Phe Ala 
            500                 505                 510         


Gln Arg Tyr Arg Val Arg Ile Arg Tyr Ala Ser Thr Thr Asp Leu Gln 
        515                 520                 525             


Phe His Thr Ser Ile Asn Gly Lys Ala Ile Asn Gln Gly Asn Phe Ser 
    530                 535                 540                 


Ala Thr Met Asn Arg Gly Glu Asp Leu Asp Tyr Lys Thr Phe Arg Thr 
545                 550                 555                 560 


Val Gly Phe Thr Thr Pro Phe Ser Phe Ser Asp Val Gln Ser Thr Phe 
                565                 570                 575     


Thr Ile Gly Ala Trp Asn Phe Ser Ser Gly Asn Glu Val Tyr Ile Asp 
            580                 585                 590         


Arg Ile Glu Phe Val Pro Val Glu Val Thr Tyr Gly Ala Glu Tyr Asp 
        595                 600                 605             


Phe Glu Lys 
    610     


<210>  5
<211>  1836
<212>  DNA
<213>  Artificial

<220>
<223>  A DNA sequence encoding the truncated TIC2199 protein of SEQ ID 
       NO:4 for expression in bacteria.

<400>  5
atgtctaagt ataaaaatgt agcgccattt gttagcgcat caacaattca aacggggatt       60

ggaattgctg gtaagattct tggtactcta ggtgttcctt ttgctggaca aatagctagc      120

ctctatagtt ttatcttagg cgagctttgg cctaaaggga aaagtcaatg ggaaatcttt      180

atggaacatg tagaagagat tattaatcaa aaaatatcaa cttatgcaag aaataaagct      240

ctttcagact tgagaggatt aggggatgct ttagccgtct accatgaatc gcttgaaagt      300

tgggttgaaa atcgtaataa cactcgagcg aggagtgtag tcaagaacca atatatcgca      360

ttagaactga tgtttgttca aaaactacct tcttttgcag tatctggtga ggaagtacca      420

ttattaccga tatacgccca agctgccaat ttacatttgt tgttattaag agatgtatct      480

atttttggaa aagaatgggg attatcagct tcagaaattt caacatttta taaccgtcaa      540

gtcgaacgaa caagagatta ttccgaccat tgtgtaaaat ggtataatac aggcctaaat      600

aacttgaggg gtacaaatgc caaaagttgg gttcgttata atcaatttcg taaagatatg      660

acattaatgg tattagattt agttgcgcta ttcccaagct atgatacact tgtatatcct      720

attaaaacca cttcacaact tacaagagaa gtatatacag acgcaattgg gaccgtgcat      780

ccgaatcaag cttttgcaag tacgacttgg tataataata atgcaccttc gttctctgcc      840

atagaggctg ctgttatccg aagtccacac ctacttgatt ttctagaaaa agttacaata      900

tacagcttat taagtcggtg gagtaatact cagtatatga atatgtgggg aggacataga      960

cttgaatccc gcccaatagg aggggcatta aatacctcaa cacaaggatc taccaatact     1020

tcgattaatc cagtaacatt acagttcacg tctcgagacg tttataggac tgaatcatgg     1080

gcagggctga atttattttt aactcaacct gttaatggag tacctagagt tgatttccat     1140

tggaaattcg tcacacatcc gatcgcatct gataatttct attatccagg gtatgctgga     1200

attgggacac aattacaaga ttcagaaaat gaattaccac ctgaaacaac aggacagcca     1260

aattatgaat catatagtca tagattatct catataggac tcatttcagc atcacatgtg     1320

aaagcattgg tatattcttg gacgcatcgt agtgcagatc gtacaaatac aattgagcca     1380

aatagcatta cacaaatacc attagtaaaa gcgttcaatc tttcttcagg tgccgctgtt     1440

gtgagaggac caggatttac aggtggggat atccttcgaa gaacgaatac tggtacattt     1500

ggggatatac gagtaaatat taatccacca tttgcacaaa ggtatcgcgt aaggattcgc     1560

tatgcttcta ctacagattt acaattccat acgtcaatta acggtaaagc tattaatcaa     1620

ggtaattttt cagcaactat gaatagagga gaggacttag actataaaac ctttagaact     1680

gtaggcttta ccactccatt tagcttttca gatgtacaaa gtacattcac aataggtgct     1740

tggaacttct cttcaggtaa cgaagtttat atagatagaa ttgaatttgt tccggtagaa     1800

gttacatatg gggcagaata tgattttgaa aaatag                               1836


<210>  6
<211>  1836
<212>  DNA
<213>  Artificial

<220>
<223>  A synthetic coding sequence encoding the truncated TIC2199 of SEQ
       ID NO:4 and capable of use in a plant cell.

<400>  6
atgtctaagt acaagaacgt cgcacccttc gtctcggctt ctacgatcca gacgggcatt       60

ggcatcgccg ggaagatact cggcacactc ggcgtcccgt tcgctggtca aatcgcctcg      120

ctctactcct tcatactcgg tgaactgtgg ccgaagggca agtcgcagtg ggaaatcttc      180

atggagcacg tggaggagat catcaaccag aagataagca cctacgcccg taacaaggcg      240

ctgagcgacc tccgtgggct gggcgatgcg ctggcggtgt accacgagtc gctggagtcg      300

tgggtggaga accgcaacaa cacccgcgcc cggtccgtgg tcaagaacca gtacattgcc      360

ctggagctga tgttcgtgca gaagctcccg tccttcgcgg tgtccggcga ggaagtgcca      420

ctgttgccca tctacgccca agcagccaac ctgcacctcc ttctcctccg ggacgtcagc      480

atcttcggga aggagtgggg cctttcagcg tcagagattt caaccttcta caacaggcaa      540

gttgagcgca cgcgcgacta ctcggaccac tgcgtcaagt ggtacaacac cggcctcaac      600

aacctgcgtg gaacgaacgc caagagctgg gtccgctaca accagtttcg aaaggacatg      660

accctcatgg tgctggacct tgtggccttg ttcccgtcct acgacaccct cgtttatccg      720

attaagacta catctcaact tacccgcgag gtttacacag acgccatagg gaccgtgcat      780

cctaaccagg cgttcgcatc gacaacttgg tacaacaaca acgcgccctc gttctcagcc      840

atcgaggccg ccgtgatccg ttcaccgcac ctcctggact tcctggagaa ggttaccatc      900

tactccctct tgtctcgctg gagtaatact cagtacatga acatgtgggg aggacatcgc      960

ctcgaatctc gaccgattgg cggcgcgctt aacacatcca cacagggctc cacgaacacc     1020

agcatcaacc cggtgacgtt gcaattcact tcacgcgatg tctatcggac cgagagctgg     1080

gctggcctga acctgttcct aactcagccc gtgaacggtg tgcccagagt cgatttccac     1140

tggaaattcg tcactcatcc catcgccagc gacaacttct actacccagg ctacgccggt     1200

atcggcacac agcttcaaga ctccgagaac gaactgcctc ccgagactac tggccagccg     1260

aactacgaga gttactccca taggctttcg cacatcggcc taatctcagc ttcgcatgtt     1320

aaagcactcg tgtactcatg gacacacaga agcgccgaca gaacgaacac cattgagcca     1380

aactctatca cgcagatccc gctggttaag gcgttcaact tgtcgagcgg cgctgcggtc     1440

gtgcgcggac ctggattcac cggtggcgac attctgcgcc gcaccaacac aggaaccttc     1500

ggcgacatcc gggtgaacat caacccgccg tttgcacaac gctatcgcgt caggatacgg     1560

tacgcatcca cgacggacct ccagttccac accagcatca acgggaaggc tatcaaccag     1620

ggaaacttta gcgccacgat gaaccgtggt gaggacttgg actacaagac attccggacg     1680

gtcggcttca cgacgccctt cagctttagc gacgtccagt ccaccttcac catcggagca     1740

tggaacttca gtagcggcaa cgaggtgtac atcgaccgaa tcgagttcgt cccggttgag     1800

gtgacctacg gagccgaata cgacttcgag aagtga                               1836


<210>  7
<211>  675
<212>  PRT
<213>  Artificial

<220>
<223>  An amino acid sequence of a variant of TIC2199, TIC2199_1 in 
       which the N-terminal 44 amino acids comprising a secretion 
       peptide have been removed.

<400>  7

Met Ser Lys Tyr Lys Asn Val Ala Pro Phe Val Ser Ala Ser Thr Ile 
1               5                   10                  15      


Gln Thr Gly Ile Gly Ile Ala Gly Lys Ile Leu Gly Thr Leu Gly Val 
            20                  25                  30          


Pro Phe Ala Gly Gln Ile Ala Ser Leu Tyr Ser Phe Ile Leu Gly Glu 
        35                  40                  45              


Leu Trp Pro Lys Gly Lys Ser Gln Trp Glu Ile Phe Met Glu His Val 
    50                  55                  60                  


Glu Glu Ile Ile Asn Gln Lys Ile Ser Thr Tyr Ala Arg Asn Lys Ala 
65                  70                  75                  80  


Leu Ser Asp Leu Arg Gly Leu Gly Asp Ala Leu Ala Val Tyr His Glu 
                85                  90                  95      


Ser Leu Glu Ser Trp Val Glu Asn Arg Asn Asn Thr Arg Ala Arg Ser 
            100                 105                 110         


Val Val Lys Asn Gln Tyr Ile Ala Leu Glu Leu Met Phe Val Gln Lys 
        115                 120                 125             


Leu Pro Ser Phe Ala Val Ser Gly Glu Glu Val Pro Leu Leu Pro Ile 
    130                 135                 140                 


Tyr Ala Gln Ala Ala Asn Leu His Leu Leu Leu Leu Arg Asp Val Ser 
145                 150                 155                 160 


Ile Phe Gly Lys Glu Trp Gly Leu Ser Ala Ser Glu Ile Ser Thr Phe 
                165                 170                 175     


Tyr Asn Arg Gln Val Glu Arg Thr Arg Asp Tyr Ser Asp His Cys Val 
            180                 185                 190         


Lys Trp Tyr Asn Thr Gly Leu Asn Asn Leu Arg Gly Thr Asn Ala Lys 
        195                 200                 205             


Ser Trp Val Arg Tyr Asn Gln Phe Arg Lys Asp Met Thr Leu Met Val 
    210                 215                 220                 


Leu Asp Leu Val Ala Leu Phe Pro Ser Tyr Asp Thr Leu Val Tyr Pro 
225                 230                 235                 240 


Ile Lys Thr Thr Ser Gln Leu Thr Arg Glu Val Tyr Thr Asp Ala Ile 
                245                 250                 255     


Gly Thr Val His Pro Asn Gln Ala Phe Ala Ser Thr Thr Trp Tyr Asn 
            260                 265                 270         


Asn Asn Ala Pro Ser Phe Ser Ala Ile Glu Ala Ala Val Ile Arg Ser 
        275                 280                 285             


Pro His Leu Leu Asp Phe Leu Glu Lys Val Thr Ile Tyr Ser Leu Leu 
    290                 295                 300                 


Ser Arg Trp Ser Asn Thr Gln Tyr Met Asn Met Trp Gly Gly His Arg 
305                 310                 315                 320 


Leu Glu Ser Arg Pro Ile Gly Gly Ala Leu Asn Thr Ser Thr Gln Gly 
                325                 330                 335     


Ser Thr Asn Thr Ser Ile Asn Pro Val Thr Leu Gln Phe Thr Ser Arg 
            340                 345                 350         


Asp Val Tyr Arg Thr Glu Ser Trp Ala Gly Leu Asn Leu Phe Leu Thr 
        355                 360                 365             


Gln Pro Val Asn Gly Val Pro Arg Val Asp Phe His Trp Lys Phe Val 
    370                 375                 380                 


Thr His Pro Ile Ala Ser Asp Asn Phe Tyr Tyr Pro Gly Tyr Ala Gly 
385                 390                 395                 400 


Ile Gly Thr Gln Leu Gln Asp Ser Glu Asn Glu Leu Pro Pro Glu Thr 
                405                 410                 415     


Thr Gly Gln Pro Asn Tyr Glu Ser Tyr Ser His Arg Leu Ser His Ile 
            420                 425                 430         


Gly Leu Ile Ser Ala Ser His Val Lys Ala Leu Val Tyr Ser Trp Thr 
        435                 440                 445             


His Arg Ser Ala Asp Arg Thr Asn Thr Ile Glu Pro Asn Ser Ile Thr 
    450                 455                 460                 


Gln Ile Pro Leu Val Lys Ala Phe Asn Leu Ser Ser Gly Ala Ala Val 
465                 470                 475                 480 


Val Arg Gly Pro Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Thr Asn 
                485                 490                 495     


Thr Gly Thr Phe Gly Asp Ile Arg Val Asn Ile Asn Pro Pro Phe Ala 
            500                 505                 510         


Gln Arg Tyr Arg Val Arg Ile Arg Tyr Ala Ser Thr Thr Asp Leu Gln 
        515                 520                 525             


Phe His Thr Ser Ile Asn Gly Lys Ala Ile Asn Gln Gly Asn Phe Ser 
    530                 535                 540                 


Ala Thr Met Asn Arg Gly Glu Asp Leu Asp Tyr Lys Thr Phe Arg Thr 
545                 550                 555                 560 


Val Gly Phe Thr Thr Pro Phe Ser Phe Ser Asp Val Gln Ser Thr Phe 
                565                 570                 575     


Thr Ile Gly Ala Trp Asn Phe Ser Ser Gly Asn Glu Val Tyr Ile Asp 
            580                 585                 590         


Arg Ile Glu Phe Val Pro Val Glu Val Thr Tyr Gly Ala Glu Tyr Asp 
        595                 600                 605             


Phe Glu Lys Ala Gln Glu Lys Val Thr Ala Leu Phe Thr Ser Thr Asn 
    610                 615                 620                 


Pro Arg Glu Leu Lys Ile Asp Val Thr Asp Tyr His Ile Asp Gln Val 
625                 630                 635                 640 


Ser Asn Leu Val Glu Ser Leu Leu Asp Glu Phe Tyr Leu Asp Glu Lys 
                645                 650                 655     


Arg Glu Leu Phe Glu Ile Val Lys Tyr Ala Lys Gln Leu Tyr Ile Glu 
            660                 665                 670         


Arg Asn Met 
        675 


<210>  8
<211>  2028
<212>  DNA
<213>  Artificial

<220>
<223>  A DNA sequence encoding the TIC2199_1 variant of SEQ ID NO:7.

<400>  8
atgtctaagt ataaaaatgt agcgccattt gttagcgcat caacaattca aacggggatt       60

ggaattgctg gtaagattct tggtactcta ggtgttcctt ttgctggaca aatagctagc      120

ctctatagtt ttatcttagg cgagctttgg cctaaaggga aaagtcaatg ggaaatcttt      180

atggaacatg tagaagagat tattaatcaa aaaatatcaa cttatgcaag aaataaagct      240

ctttcagact tgagaggatt aggggatgct ttagccgtct accatgaatc gcttgaaagt      300

tgggttgaaa atcgtaataa cactcgagcg aggagtgtag tcaagaacca atatatcgca      360

ttagaactga tgtttgttca aaaactacct tcttttgcag tatctggtga ggaagtacca      420

ttattaccga tatacgccca agctgccaat ttacatttgt tgttattaag agatgtatct      480

atttttggaa aagaatgggg attatcagct tcagaaattt caacatttta taaccgtcaa      540

gtcgaacgaa caagagatta ttccgaccat tgtgtaaaat ggtataatac aggcctaaat      600

aacttgaggg gtacaaatgc caaaagttgg gttcgttata atcaatttcg taaagatatg      660

acattaatgg tattagattt agttgcgcta ttcccaagct atgatacact tgtatatcct      720

attaaaacca cttcacaact tacaagagaa gtatatacag acgcaattgg gaccgtgcat      780

ccgaatcaag cttttgcaag tacgacttgg tataataata atgcaccttc gttctctgcc      840

atagaggctg ctgttatccg aagtccacac ctacttgatt ttctagaaaa agttacaata      900

tacagcttat taagtcggtg gagtaatact cagtatatga atatgtgggg aggacataga      960

cttgaatccc gcccaatagg aggggcatta aatacctcaa cacaaggatc taccaatact     1020

tcgattaatc cagtaacatt acagttcacg tctcgagacg tttataggac tgaatcatgg     1080

gcagggctga atttattttt aactcaacct gttaatggag tacctagagt tgatttccat     1140

tggaaattcg tcacacatcc gatcgcatct gataatttct attatccagg gtatgctgga     1200

attgggacac aattacaaga ttcagaaaat gaattaccac ctgaaacaac aggacagcca     1260

aattatgaat catatagtca tagattatct catataggac tcatttcagc atcacatgtg     1320

aaagcattgg tatattcttg gacgcatcgt agtgcagatc gtacaaatac aattgagcca     1380

aatagcatta cacaaatacc attagtaaaa gcgttcaatc tttcttcagg tgccgctgtt     1440

gtgagaggac caggatttac aggtggggat atccttcgaa gaacgaatac tggtacattt     1500

ggggatatac gagtaaatat taatccacca tttgcacaaa ggtatcgcgt aaggattcgc     1560

tatgcttcta ctacagattt acaattccat acgtcaatta acggtaaagc tattaatcaa     1620

ggtaattttt cagcaactat gaatagagga gaggacttag actataaaac ctttagaact     1680

gtaggcttta ccactccatt tagcttttca gatgtacaaa gtacattcac aataggtgct     1740

tggaacttct cttcaggtaa cgaagtttat atagatagaa ttgaatttgt tccggtagaa     1800

gttacatatg gggcagaata tgattttgaa aaagcgcaag agaaggttac tgcactgttt     1860

acatctacga atccaagaga attaaaaata gatgtaacgg attatcatat tgaccaggta     1920

tcaaatttag tagagtctct attagacgaa ttctatcttg atgaaaagag agaattattc     1980

gagatagtta aatacgcgaa gcaactctat attgagcgta acatgtag                  2028


<210>  9
<211>  2028
<212>  DNA
<213>  Artificial

<220>
<223>  A synthetic coding sequence encoding the TIC2199_1 variant of SEQ
       ID NO:7 and capable of use in a plant cell..

<400>  9
atgtctaagt acaagaacgt cgcacccttc gtctcggctt ctacgatcca gacgggcatt       60

ggcatcgccg ggaagatact cggcacactc ggcgtcccgt tcgctggtca aatcgcctcg      120

ctctactcct tcatactcgg tgaactgtgg ccgaagggca agtcgcagtg ggaaatcttc      180

atggagcacg tggaggagat catcaaccag aagataagca cctacgcccg taacaaggcg      240

ctgagcgacc tccgtgggct gggcgatgcg ctggcggtgt accacgagtc gctggagtcg      300

tgggtggaga accgcaacaa cacccgcgcc cggtccgtgg tcaagaacca gtacattgcc      360

ctggagctga tgttcgtgca gaagctcccg tccttcgcgg tgtccggcga ggaagtgcca      420

ctgttgccca tctacgccca agcagccaac ctgcacctcc ttctcctccg ggacgtcagc      480

atcttcggga aggagtgggg cctttcagcg tcagagattt caaccttcta caacaggcaa      540

gttgagcgca cgcgcgacta ctcggaccac tgcgtcaagt ggtacaacac cggcctcaac      600

aacctgcgtg gaacgaacgc caagagctgg gtccgctaca accagtttcg aaaggacatg      660

accctcatgg tgctggacct tgtggccttg ttcccgtcct acgacaccct cgtttatccg      720

attaagacta catctcaact tacccgcgag gtttacacag acgccatagg gaccgtgcat      780

cctaaccagg cgttcgcatc gacaacttgg tacaacaaca acgcgccctc gttctcagcc      840

atcgaggccg ccgtgatccg ttcaccgcac ctcctggact tcctggagaa ggttaccatc      900

tactccctct tgtctcgctg gagtaatact cagtacatga acatgtgggg aggacatcgc      960

ctcgaatctc gaccgattgg cggcgcgctt aacacatcca cacagggctc cacgaacacc     1020

agcatcaacc cggtgacgtt gcaattcact tcacgcgatg tctatcggac cgagagctgg     1080

gctggcctga acctgttcct aactcagccc gtgaacggtg tgcccagagt cgatttccac     1140

tggaaattcg tcactcatcc catcgccagc gacaacttct actacccagg ctacgccggt     1200

atcggcacac agcttcaaga ctccgagaac gaactgcctc ccgagactac tggccagccg     1260

aactacgaga gttactccca taggctttcg cacatcggcc taatctcagc ttcgcatgtt     1320

aaagcactcg tgtactcatg gacacacaga agcgccgaca gaacgaacac cattgagcca     1380

aactctatca cgcagatccc gctggttaag gcgttcaact tgtcgagcgg cgctgcggtc     1440

gtgcgcggac ctggattcac cggtggcgac attctgcgcc gcaccaacac aggaaccttc     1500

ggcgacatcc gggtgaacat caacccgccg tttgcacaac gctatcgcgt caggatacgg     1560

tacgcatcca cgacggacct ccagttccac accagcatca acgggaaggc tatcaaccag     1620

ggaaacttta gcgccacgat gaaccgtggt gaggacttgg actacaagac attccggacg     1680

gtcggcttca cgacgccctt cagctttagc gacgtccagt ccaccttcac catcggagca     1740

tggaacttca gtagcggcaa cgaggtgtac atcgaccgaa tcgagttcgt cccggttgag     1800

gtgacctacg gagccgaata cgacttcgag aaggcacagg agaaggtgac tgctctgttt     1860

acaagcacaa atcctcggga actaaagatc gacgtcacag actaccacat cgaccaagtt     1920

agcaacctcg tcgagagcct cctggacgag ttctatttgg acgagaagcg ggagctgttc     1980

gagatcgtga aatacgccaa gcagttgtac atcgagcgta acatgtga                  2028


<210>  10
<211>  655
<212>  PRT
<213>  Artificial

<220>
<223>  An amino acid sequence of a variant of TIC2199, TIC2199_2 in 
       which the C-terminal 64 amino acids are also removed..

<400>  10

Met Lys Pro Lys Asn Gln Asn Met Tyr Gln Ser Leu Ser Ser Asn Val 
1               5                   10                  15      


Thr Val Asp Lys Ile Ser Thr Asn Pro Leu Lys Asn Glu Thr Asp Ile 
            20                  25                  30          


Glu Leu Gln Asn Ile Asn His Glu Ala Cys Leu Lys Met Ser Lys Tyr 
        35                  40                  45              


Lys Asn Val Ala Pro Phe Val Ser Ala Ser Thr Ile Gln Thr Gly Ile 
    50                  55                  60                  


Gly Ile Ala Gly Lys Ile Leu Gly Thr Leu Gly Val Pro Phe Ala Gly 
65                  70                  75                  80  


Gln Ile Ala Ser Leu Tyr Ser Phe Ile Leu Gly Glu Leu Trp Pro Lys 
                85                  90                  95      


Gly Lys Ser Gln Trp Glu Ile Phe Met Glu His Val Glu Glu Ile Ile 
            100                 105                 110         


Asn Gln Lys Ile Ser Thr Tyr Ala Arg Asn Lys Ala Leu Ser Asp Leu 
        115                 120                 125             


Arg Gly Leu Gly Asp Ala Leu Ala Val Tyr His Glu Ser Leu Glu Ser 
    130                 135                 140                 


Trp Val Glu Asn Arg Asn Asn Thr Arg Ala Arg Ser Val Val Lys Asn 
145                 150                 155                 160 


Gln Tyr Ile Ala Leu Glu Leu Met Phe Val Gln Lys Leu Pro Ser Phe 
                165                 170                 175     


Ala Val Ser Gly Glu Glu Val Pro Leu Leu Pro Ile Tyr Ala Gln Ala 
            180                 185                 190         


Ala Asn Leu His Leu Leu Leu Leu Arg Asp Val Ser Ile Phe Gly Lys 
        195                 200                 205             


Glu Trp Gly Leu Ser Ala Ser Glu Ile Ser Thr Phe Tyr Asn Arg Gln 
    210                 215                 220                 


Val Glu Arg Thr Arg Asp Tyr Ser Asp His Cys Val Lys Trp Tyr Asn 
225                 230                 235                 240 


Thr Gly Leu Asn Asn Leu Arg Gly Thr Asn Ala Lys Ser Trp Val Arg 
                245                 250                 255     


Tyr Asn Gln Phe Arg Lys Asp Met Thr Leu Met Val Leu Asp Leu Val 
            260                 265                 270         


Ala Leu Phe Pro Ser Tyr Asp Thr Leu Val Tyr Pro Ile Lys Thr Thr 
        275                 280                 285             


Ser Gln Leu Thr Arg Glu Val Tyr Thr Asp Ala Ile Gly Thr Val His 
    290                 295                 300                 


Pro Asn Gln Ala Phe Ala Ser Thr Thr Trp Tyr Asn Asn Asn Ala Pro 
305                 310                 315                 320 


Ser Phe Ser Ala Ile Glu Ala Ala Val Ile Arg Ser Pro His Leu Leu 
                325                 330                 335     


Asp Phe Leu Glu Lys Val Thr Ile Tyr Ser Leu Leu Ser Arg Trp Ser 
            340                 345                 350         


Asn Thr Gln Tyr Met Asn Met Trp Gly Gly His Arg Leu Glu Ser Arg 
        355                 360                 365             


Pro Ile Gly Gly Ala Leu Asn Thr Ser Thr Gln Gly Ser Thr Asn Thr 
    370                 375                 380                 


Ser Ile Asn Pro Val Thr Leu Gln Phe Thr Ser Arg Asp Val Tyr Arg 
385                 390                 395                 400 


Thr Glu Ser Trp Ala Gly Leu Asn Leu Phe Leu Thr Gln Pro Val Asn 
                405                 410                 415     


Gly Val Pro Arg Val Asp Phe His Trp Lys Phe Val Thr His Pro Ile 
            420                 425                 430         


Ala Ser Asp Asn Phe Tyr Tyr Pro Gly Tyr Ala Gly Ile Gly Thr Gln 
        435                 440                 445             


Leu Gln Asp Ser Glu Asn Glu Leu Pro Pro Glu Thr Thr Gly Gln Pro 
    450                 455                 460                 


Asn Tyr Glu Ser Tyr Ser His Arg Leu Ser His Ile Gly Leu Ile Ser 
465                 470                 475                 480 


Ala Ser His Val Lys Ala Leu Val Tyr Ser Trp Thr His Arg Ser Ala 
                485                 490                 495     


Asp Arg Thr Asn Thr Ile Glu Pro Asn Ser Ile Thr Gln Ile Pro Leu 
            500                 505                 510         


Val Lys Ala Phe Asn Leu Ser Ser Gly Ala Ala Val Val Arg Gly Pro 
        515                 520                 525             


Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Thr Asn Thr Gly Thr Phe 
    530                 535                 540                 


Gly Asp Ile Arg Val Asn Ile Asn Pro Pro Phe Ala Gln Arg Tyr Arg 
545                 550                 555                 560 


Val Arg Ile Arg Tyr Ala Ser Thr Thr Asp Leu Gln Phe His Thr Ser 
                565                 570                 575     


Ile Asn Gly Lys Ala Ile Asn Gln Gly Asn Phe Ser Ala Thr Met Asn 
            580                 585                 590         


Arg Gly Glu Asp Leu Asp Tyr Lys Thr Phe Arg Thr Val Gly Phe Thr 
        595                 600                 605             


Thr Pro Phe Ser Phe Ser Asp Val Gln Ser Thr Phe Thr Ile Gly Ala 
    610                 615                 620                 


Trp Asn Phe Ser Ser Gly Asn Glu Val Tyr Ile Asp Arg Ile Glu Phe 
625                 630                 635                 640 


Val Pro Val Glu Val Thr Tyr Gly Ala Glu Tyr Asp Phe Glu Lys 
                645                 650                 655 


<210>  11
<211>  1968
<212>  DNA
<213>  Artificial

<220>
<223>  A DNA sequence encoding the TIC2199_2 variant of SEQ ID NO:10.

<400>  11
atgaaaccaa agaatcaaaa tatgtatcaa agcttgtcta gcaatgtgac agttgataaa       60

atctctacaa atccactaaa aaatgaaaca gatatagaat tacaaaatat taatcatgaa      120

gcttgtttaa aaatgtctaa gtataaaaat gtagcgccat ttgttagcgc atcaacaatt      180

caaacgggga ttggaattgc tggtaagatt cttggtactc taggtgttcc ttttgctgga      240

caaatagcta gcctctatag ttttatctta ggcgagcttt ggcctaaagg gaaaagtcaa      300

tgggaaatct ttatggaaca tgtagaagag attattaatc aaaaaatatc aacttatgca      360

agaaataaag ctctttcaga cttgagagga ttaggggatg ctttagccgt ctaccatgaa      420

tcgcttgaaa gttgggttga aaatcgtaat aacactcgag cgaggagtgt agtcaagaac      480

caatatatcg cattagaact gatgtttgtt caaaaactac cttcttttgc agtatctggt      540

gaggaagtac cattattacc gatatacgcc caagctgcca atttacattt gttgttatta      600

agagatgtat ctatttttgg aaaagaatgg ggattatcag cttcagaaat ttcaacattt      660

tataaccgtc aagtcgaacg aacaagagat tattccgacc attgtgtaaa atggtataat      720

acaggcctaa ataacttgag gggtacaaat gccaaaagtt gggttcgtta taatcaattt      780

cgtaaagata tgacattaat ggtattagat ttagttgcgc tattcccaag ctatgataca      840

cttgtatatc ctattaaaac cacttcacaa cttacaagag aagtatatac agacgcaatt      900

gggaccgtgc atccgaatca agcttttgca agtacgactt ggtataataa taatgcacct      960

tcgttctctg ccatagaggc tgctgttatc cgaagtccac acctacttga ttttctagaa     1020

aaagttacaa tatacagctt attaagtcgg tggagtaata ctcagtatat gaatatgtgg     1080

ggaggacata gacttgaatc ccgcccaata ggaggggcat taaatacctc aacacaagga     1140

tctaccaata cttcgattaa tccagtaaca ttacagttca cgtctcgaga cgtttatagg     1200

actgaatcat gggcagggct gaatttattt ttaactcaac ctgttaatgg agtacctaga     1260

gttgatttcc attggaaatt cgtcacacat ccgatcgcat ctgataattt ctattatcca     1320

gggtatgctg gaattgggac acaattacaa gattcagaaa atgaattacc acctgaaaca     1380

acaggacagc caaattatga atcatatagt catagattat ctcatatagg actcatttca     1440

gcatcacatg tgaaagcatt ggtatattct tggacgcatc gtagtgcaga tcgtacaaat     1500

acaattgagc caaatagcat tacacaaata ccattagtaa aagcgttcaa tctttcttca     1560

ggtgccgctg ttgtgagagg accaggattt acaggtgggg atatccttcg aagaacgaat     1620

actggtacat ttggggatat acgagtaaat attaatccac catttgcaca aaggtatcgc     1680

gtaaggattc gctatgcttc tactacagat ttacaattcc atacgtcaat taacggtaaa     1740

gctattaatc aaggtaattt ttcagcaact atgaatagag gagaggactt agactataaa     1800

acctttagaa ctgtaggctt taccactcca tttagctttt cagatgtaca aagtacattc     1860

acaataggtg cttggaactt ctcttcaggt aacgaagttt atatagatag aattgaattt     1920

gttccggtag aagttacata tggggcagaa tatgattttg aaaaatga                  1968


<210>  12
<211>  1968
<212>  DNA
<213>  Artificial

<220>
<223>  A synthetic coding sequence encoding the TIC2199_2 variant of SEQ
       ID NO:10 and capable of use in a plant cell.

<400>  12
atgaagccca agaatcagaa catgtaccag tccctcagct cgaacgtcac cgtcgataag       60

attagcacca acccgctcaa gaatgagacc gacatcgaat tacagaacat taaccacgag      120

gcgtgcctca agatgtctaa gtacaagaac gtcgcaccct tcgtctcggc ttctacgatc      180

cagacgggca ttggcatcgc cgggaagata ctcggcacac tcggcgtccc gttcgctggt      240

caaatcgcct cgctctactc cttcatactc ggtgaactgt ggccgaaggg caagtcgcag      300

tgggaaatct tcatggagca cgtggaggag atcatcaacc agaagataag cacctacgcc      360

cgtaacaagg cgctgagcga cctccgtggg ctgggcgatg cgctggcggt gtaccacgag      420

tcgctggagt cgtgggtgga gaaccgcaac aacacccgcg cccggtccgt ggtcaagaac      480

cagtacattg ccctggagct gatgttcgtg cagaagctcc cgtccttcgc ggtgtccggc      540

gaggaagtgc cactgttgcc catctacgcc caagcagcca acctgcacct ccttctcctc      600

cgggacgtca gcatcttcgg gaaggagtgg ggcctttcag cgtcagagat ttcaaccttc      660

tacaacaggc aagttgagcg cacgcgcgac tactcggacc actgcgtcaa gtggtacaac      720

accggcctca acaacctgcg tggaacgaac gccaagagct gggtccgcta caaccagttt      780

cgaaaggaca tgaccctcat ggtgctggac cttgtggcct tgttcccgtc ctacgacacc      840

ctcgtttatc cgattaagac tacatctcaa cttacccgcg aggtttacac agacgccata      900

gggaccgtgc atcctaacca ggcgttcgca tcgacaactt ggtacaacaa caacgcgccc      960

tcgttctcag ccatcgaggc cgccgtgatc cgttcaccgc acctcctgga cttcctggag     1020

aaggttacca tctactccct cttgtctcgc tggagtaata ctcagtacat gaacatgtgg     1080

ggaggacatc gcctcgaatc tcgaccgatt ggcggcgcgc ttaacacatc cacacagggc     1140

tccacgaaca ccagcatcaa cccggtgacg ttgcaattca cttcacgcga tgtctatcgg     1200

accgagagct gggctggcct gaacctgttc ctaactcagc ccgtgaacgg tgtgcccaga     1260

gtcgatttcc actggaaatt cgtcactcat cccatcgcca gcgacaactt ctactaccca     1320

ggctacgccg gtatcggcac acagcttcaa gactccgaga acgaactgcc tcccgagact     1380

actggccagc cgaactacga gagttactcc cataggcttt cgcacatcgg cctaatctca     1440

gcttcgcatg ttaaagcact cgtgtactca tggacacaca gaagcgccga cagaacgaac     1500

accattgagc caaactctat cacgcagatc ccgctggtta aggcgttcaa cttgtcgagc     1560

ggcgctgcgg tcgtgcgcgg acctggattc accggtggcg acattctgcg ccgcaccaac     1620

acaggaacct tcggcgacat ccgggtgaac atcaacccgc cgtttgcaca acgctatcgc     1680

gtcaggatac ggtacgcatc cacgacggac ctccagttcc acaccagcat caacgggaag     1740

gctatcaacc agggaaactt tagcgccacg atgaaccgtg gtgaggactt ggactacaag     1800

acattccgga cggtcggctt cacgacgccc ttcagcttta gcgacgtcca gtccaccttc     1860

accatcggag catggaactt cagtagcggc aacgaggtgt acatcgaccg aatcgagttc     1920

gtcccggttg aggtgaccta cggagccgaa tacgacttcg agaagtga                  1968


<210>  13
<211>  674
<212>  PRT
<213>  Artificial

<220>
<223>  An amino acid sequence of the variant TIC2199_1 variant with the 
       initiating methionine removed and used to operably link to a 
       chloroplast transit peptide.

<400>  13

Ser Lys Tyr Lys Asn Val Ala Pro Phe Val Ser Ala Ser Thr Ile Gln 
1               5                   10                  15      


Thr Gly Ile Gly Ile Ala Gly Lys Ile Leu Gly Thr Leu Gly Val Pro 
            20                  25                  30          


Phe Ala Gly Gln Ile Ala Ser Leu Tyr Ser Phe Ile Leu Gly Glu Leu 
        35                  40                  45              


Trp Pro Lys Gly Lys Ser Gln Trp Glu Ile Phe Met Glu His Val Glu 
    50                  55                  60                  


Glu Ile Ile Asn Gln Lys Ile Ser Thr Tyr Ala Arg Asn Lys Ala Leu 
65                  70                  75                  80  


Ser Asp Leu Arg Gly Leu Gly Asp Ala Leu Ala Val Tyr His Glu Ser 
                85                  90                  95      


Leu Glu Ser Trp Val Glu Asn Arg Asn Asn Thr Arg Ala Arg Ser Val 
            100                 105                 110         


Val Lys Asn Gln Tyr Ile Ala Leu Glu Leu Met Phe Val Gln Lys Leu 
        115                 120                 125             


Pro Ser Phe Ala Val Ser Gly Glu Glu Val Pro Leu Leu Pro Ile Tyr 
    130                 135                 140                 


Ala Gln Ala Ala Asn Leu His Leu Leu Leu Leu Arg Asp Val Ser Ile 
145                 150                 155                 160 


Phe Gly Lys Glu Trp Gly Leu Ser Ala Ser Glu Ile Ser Thr Phe Tyr 
                165                 170                 175     


Asn Arg Gln Val Glu Arg Thr Arg Asp Tyr Ser Asp His Cys Val Lys 
            180                 185                 190         


Trp Tyr Asn Thr Gly Leu Asn Asn Leu Arg Gly Thr Asn Ala Lys Ser 
        195                 200                 205             


Trp Val Arg Tyr Asn Gln Phe Arg Lys Asp Met Thr Leu Met Val Leu 
    210                 215                 220                 


Asp Leu Val Ala Leu Phe Pro Ser Tyr Asp Thr Leu Val Tyr Pro Ile 
225                 230                 235                 240 


Lys Thr Thr Ser Gln Leu Thr Arg Glu Val Tyr Thr Asp Ala Ile Gly 
                245                 250                 255     


Thr Val His Pro Asn Gln Ala Phe Ala Ser Thr Thr Trp Tyr Asn Asn 
            260                 265                 270         


Asn Ala Pro Ser Phe Ser Ala Ile Glu Ala Ala Val Ile Arg Ser Pro 
        275                 280                 285             


His Leu Leu Asp Phe Leu Glu Lys Val Thr Ile Tyr Ser Leu Leu Ser 
    290                 295                 300                 


Arg Trp Ser Asn Thr Gln Tyr Met Asn Met Trp Gly Gly His Arg Leu 
305                 310                 315                 320 


Glu Ser Arg Pro Ile Gly Gly Ala Leu Asn Thr Ser Thr Gln Gly Ser 
                325                 330                 335     


Thr Asn Thr Ser Ile Asn Pro Val Thr Leu Gln Phe Thr Ser Arg Asp 
            340                 345                 350         


Val Tyr Arg Thr Glu Ser Trp Ala Gly Leu Asn Leu Phe Leu Thr Gln 
        355                 360                 365             


Pro Val Asn Gly Val Pro Arg Val Asp Phe His Trp Lys Phe Val Thr 
    370                 375                 380                 


His Pro Ile Ala Ser Asp Asn Phe Tyr Tyr Pro Gly Tyr Ala Gly Ile 
385                 390                 395                 400 


Gly Thr Gln Leu Gln Asp Ser Glu Asn Glu Leu Pro Pro Glu Thr Thr 
                405                 410                 415     


Gly Gln Pro Asn Tyr Glu Ser Tyr Ser His Arg Leu Ser His Ile Gly 
            420                 425                 430         


Leu Ile Ser Ala Ser His Val Lys Ala Leu Val Tyr Ser Trp Thr His 
        435                 440                 445             


Arg Ser Ala Asp Arg Thr Asn Thr Ile Glu Pro Asn Ser Ile Thr Gln 
    450                 455                 460                 


Ile Pro Leu Val Lys Ala Phe Asn Leu Ser Ser Gly Ala Ala Val Val 
465                 470                 475                 480 


Arg Gly Pro Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Thr Asn Thr 
                485                 490                 495     


Gly Thr Phe Gly Asp Ile Arg Val Asn Ile Asn Pro Pro Phe Ala Gln 
            500                 505                 510         


Arg Tyr Arg Val Arg Ile Arg Tyr Ala Ser Thr Thr Asp Leu Gln Phe 
        515                 520                 525             


His Thr Ser Ile Asn Gly Lys Ala Ile Asn Gln Gly Asn Phe Ser Ala 
    530                 535                 540                 


Thr Met Asn Arg Gly Glu Asp Leu Asp Tyr Lys Thr Phe Arg Thr Val 
545                 550                 555                 560 


Gly Phe Thr Thr Pro Phe Ser Phe Ser Asp Val Gln Ser Thr Phe Thr 
                565                 570                 575     


Ile Gly Ala Trp Asn Phe Ser Ser Gly Asn Glu Val Tyr Ile Asp Arg 
            580                 585                 590         


Ile Glu Phe Val Pro Val Glu Val Thr Tyr Gly Ala Glu Tyr Asp Phe 
        595                 600                 605             


Glu Lys Ala Gln Glu Lys Val Thr Ala Leu Phe Thr Ser Thr Asn Pro 
    610                 615                 620                 


Arg Glu Leu Lys Ile Asp Val Thr Asp Tyr His Ile Asp Gln Val Ser 
625                 630                 635                 640 


Asn Leu Val Glu Ser Leu Leu Asp Glu Phe Tyr Leu Asp Glu Lys Arg 
                645                 650                 655     


Glu Leu Phe Glu Ile Val Lys Tyr Ala Lys Gln Leu Tyr Ile Glu Arg 
            660                 665                 670         


Asn Met 
        


<210>  14
<211>  2025
<212>  DNA
<213>  Artificial

<220>
<223>  A synthetic coding sequence encoding the TIC2199_1 variant with 
       the initiating methionine codon removed and used to operably link
       to a chloroplast transit peptide, and capable of use in a plant 
       cell.

<400>  14
tctaagtaca agaacgtcgc acccttcgtc tcggcttcta cgatccagac gggcattggc       60

atcgccggga agatactcgg cacactcggc gtcccgttcg ctggtcaaat cgcctcgctc      120

tactccttca tactcggtga actgtggccg aagggcaagt cgcagtggga aatcttcatg      180

gagcacgtgg aggagatcat caaccagaag ataagcacct acgcccgtaa caaggcgctg      240

agcgacctcc gtgggctggg cgatgcgctg gcggtgtacc acgagtcgct ggagtcgtgg      300

gtggagaacc gcaacaacac ccgcgcccgg tccgtggtca agaaccagta cattgccctg      360

gagctgatgt tcgtgcagaa gctcccgtcc ttcgcggtgt ccggcgagga agtgccactg      420

ttgcccatct acgcccaagc agccaacctg cacctccttc tcctccggga cgtcagcatc      480

ttcgggaagg agtggggcct ttcagcgtca gagatttcaa ccttctacaa caggcaagtt      540

gagcgcacgc gcgactactc ggaccactgc gtcaagtggt acaacaccgg cctcaacaac      600

ctgcgtggaa cgaacgccaa gagctgggtc cgctacaacc agtttcgaaa ggacatgacc      660

ctcatggtgc tggaccttgt ggccttgttc ccgtcctacg acaccctcgt ttatccgatt      720

aagactacat ctcaacttac ccgcgaggtt tacacagacg ccatagggac cgtgcatcct      780

aaccaggcgt tcgcatcgac aacttggtac aacaacaacg cgccctcgtt ctcagccatc      840

gaggccgccg tgatccgttc accgcacctc ctggacttcc tggagaaggt taccatctac      900

tccctcttgt ctcgctggag taatactcag tacatgaaca tgtggggagg acatcgcctc      960

gaatctcgac cgattggcgg cgcgcttaac acatccacac agggctccac gaacaccagc     1020

atcaacccgg tgacgttgca attcacttca cgcgatgtct atcggaccga gagctgggct     1080

ggcctgaacc tgttcctaac tcagcccgtg aacggtgtgc ccagagtcga tttccactgg     1140

aaattcgtca ctcatcccat cgccagcgac aacttctact acccaggcta cgccggtatc     1200

ggcacacagc ttcaagactc cgagaacgaa ctgcctcccg agactactgg ccagccgaac     1260

tacgagagtt actcccatag gctttcgcac atcggcctaa tctcagcttc gcatgttaaa     1320

gcactcgtgt actcatggac acacagaagc gccgacagaa cgaacaccat tgagccaaac     1380

tctatcacgc agatcccgct ggttaaggcg ttcaacttgt cgagcggcgc tgcggtcgtg     1440

cgcggacctg gattcaccgg tggcgacatt ctgcgccgca ccaacacagg aaccttcggc     1500

gacatccggg tgaacatcaa cccgccgttt gcacaacgct atcgcgtcag gatacggtac     1560

gcatccacga cggacctcca gttccacacc agcatcaacg ggaaggctat caaccaggga     1620

aactttagcg ccacgatgaa ccgtggtgag gacttggact acaagacatt ccggacggtc     1680

ggcttcacga cgcccttcag ctttagcgac gtccagtcca ccttcaccat cggagcatgg     1740

aacttcagta gcggcaacga ggtgtacatc gaccgaatcg agttcgtccc ggttgaggtg     1800

acctacggag ccgaatacga cttcgagaag gcacaggaga aggtgactgc tctgtttaca     1860

agcacaaatc ctcgggaact aaagatcgac gtcacagact accacatcga ccaagttagc     1920

aacctcgtcg agagcctcct ggacgagttc tatttggacg agaagcggga gctgttcgag     1980

atcgtgaaat acgccaagca gttgtacatc gagcgtaaca tgtga                     2025


<210>  15
<211>  654
<212>  PRT
<213>  Artificial

<220>
<223>  An amino acid sequence of the variant TIC2199_2 variant with the 
       initiating methionine removed and used to operably link to a 
       chloroplast transit peptide.

<400>  15

Lys Pro Lys Asn Gln Asn Met Tyr Gln Ser Leu Ser Ser Asn Val Thr 
1               5                   10                  15      


Val Asp Lys Ile Ser Thr Asn Pro Leu Lys Asn Glu Thr Asp Ile Glu 
            20                  25                  30          


Leu Gln Asn Ile Asn His Glu Ala Cys Leu Lys Met Ser Lys Tyr Lys 
        35                  40                  45              


Asn Val Ala Pro Phe Val Ser Ala Ser Thr Ile Gln Thr Gly Ile Gly 
    50                  55                  60                  


Ile Ala Gly Lys Ile Leu Gly Thr Leu Gly Val Pro Phe Ala Gly Gln 
65                  70                  75                  80  


Ile Ala Ser Leu Tyr Ser Phe Ile Leu Gly Glu Leu Trp Pro Lys Gly 
                85                  90                  95      


Lys Ser Gln Trp Glu Ile Phe Met Glu His Val Glu Glu Ile Ile Asn 
            100                 105                 110         


Gln Lys Ile Ser Thr Tyr Ala Arg Asn Lys Ala Leu Ser Asp Leu Arg 
        115                 120                 125             


Gly Leu Gly Asp Ala Leu Ala Val Tyr His Glu Ser Leu Glu Ser Trp 
    130                 135                 140                 


Val Glu Asn Arg Asn Asn Thr Arg Ala Arg Ser Val Val Lys Asn Gln 
145                 150                 155                 160 


Tyr Ile Ala Leu Glu Leu Met Phe Val Gln Lys Leu Pro Ser Phe Ala 
                165                 170                 175     


Val Ser Gly Glu Glu Val Pro Leu Leu Pro Ile Tyr Ala Gln Ala Ala 
            180                 185                 190         


Asn Leu His Leu Leu Leu Leu Arg Asp Val Ser Ile Phe Gly Lys Glu 
        195                 200                 205             


Trp Gly Leu Ser Ala Ser Glu Ile Ser Thr Phe Tyr Asn Arg Gln Val 
    210                 215                 220                 


Glu Arg Thr Arg Asp Tyr Ser Asp His Cys Val Lys Trp Tyr Asn Thr 
225                 230                 235                 240 


Gly Leu Asn Asn Leu Arg Gly Thr Asn Ala Lys Ser Trp Val Arg Tyr 
                245                 250                 255     


Asn Gln Phe Arg Lys Asp Met Thr Leu Met Val Leu Asp Leu Val Ala 
            260                 265                 270         


Leu Phe Pro Ser Tyr Asp Thr Leu Val Tyr Pro Ile Lys Thr Thr Ser 
        275                 280                 285             


Gln Leu Thr Arg Glu Val Tyr Thr Asp Ala Ile Gly Thr Val His Pro 
    290                 295                 300                 


Asn Gln Ala Phe Ala Ser Thr Thr Trp Tyr Asn Asn Asn Ala Pro Ser 
305                 310                 315                 320 


Phe Ser Ala Ile Glu Ala Ala Val Ile Arg Ser Pro His Leu Leu Asp 
                325                 330                 335     


Phe Leu Glu Lys Val Thr Ile Tyr Ser Leu Leu Ser Arg Trp Ser Asn 
            340                 345                 350         


Thr Gln Tyr Met Asn Met Trp Gly Gly His Arg Leu Glu Ser Arg Pro 
        355                 360                 365             


Ile Gly Gly Ala Leu Asn Thr Ser Thr Gln Gly Ser Thr Asn Thr Ser 
    370                 375                 380                 


Ile Asn Pro Val Thr Leu Gln Phe Thr Ser Arg Asp Val Tyr Arg Thr 
385                 390                 395                 400 


Glu Ser Trp Ala Gly Leu Asn Leu Phe Leu Thr Gln Pro Val Asn Gly 
                405                 410                 415     


Val Pro Arg Val Asp Phe His Trp Lys Phe Val Thr His Pro Ile Ala 
            420                 425                 430         


Ser Asp Asn Phe Tyr Tyr Pro Gly Tyr Ala Gly Ile Gly Thr Gln Leu 
        435                 440                 445             


Gln Asp Ser Glu Asn Glu Leu Pro Pro Glu Thr Thr Gly Gln Pro Asn 
    450                 455                 460                 


Tyr Glu Ser Tyr Ser His Arg Leu Ser His Ile Gly Leu Ile Ser Ala 
465                 470                 475                 480 


Ser His Val Lys Ala Leu Val Tyr Ser Trp Thr His Arg Ser Ala Asp 
                485                 490                 495     


Arg Thr Asn Thr Ile Glu Pro Asn Ser Ile Thr Gln Ile Pro Leu Val 
            500                 505                 510         


Lys Ala Phe Asn Leu Ser Ser Gly Ala Ala Val Val Arg Gly Pro Gly 
        515                 520                 525             


Phe Thr Gly Gly Asp Ile Leu Arg Arg Thr Asn Thr Gly Thr Phe Gly 
    530                 535                 540                 


Asp Ile Arg Val Asn Ile Asn Pro Pro Phe Ala Gln Arg Tyr Arg Val 
545                 550                 555                 560 


Arg Ile Arg Tyr Ala Ser Thr Thr Asp Leu Gln Phe His Thr Ser Ile 
                565                 570                 575     


Asn Gly Lys Ala Ile Asn Gln Gly Asn Phe Ser Ala Thr Met Asn Arg 
            580                 585                 590         


Gly Glu Asp Leu Asp Tyr Lys Thr Phe Arg Thr Val Gly Phe Thr Thr 
        595                 600                 605             


Pro Phe Ser Phe Ser Asp Val Gln Ser Thr Phe Thr Ile Gly Ala Trp 
    610                 615                 620                 


Asn Phe Ser Ser Gly Asn Glu Val Tyr Ile Asp Arg Ile Glu Phe Val 
625                 630                 635                 640 


Pro Val Glu Val Thr Tyr Gly Ala Glu Tyr Asp Phe Glu Lys 
                645                 650                 


<210>  16
<211>  1965
<212>  DNA
<213>  Artificial

<220>
<223>  A synthetic coding sequence encoding the TIC2199_2 variant with 
       the initiating methionine codon removed and used to operably link
       to a chloroplast transit peptide, and capable of use in a plant 
       cell.

<400>  16
aagcccaaga atcagaacat gtaccagtcc ctcagctcga acgtcaccgt cgataagatt       60

agcaccaacc cgctcaagaa tgagaccgac atcgaattac agaacattaa ccacgaggcg      120

tgcctcaaga tgtctaagta caagaacgtc gcacccttcg tctcggcttc tacgatccag      180

acgggcattg gcatcgccgg gaagatactc ggcacactcg gcgtcccgtt cgctggtcaa      240

atcgcctcgc tctactcctt catactcggt gaactgtggc cgaagggcaa gtcgcagtgg      300

gaaatcttca tggagcacgt ggaggagatc atcaaccaga agataagcac ctacgcccgt      360

aacaaggcgc tgagcgacct ccgtgggctg ggcgatgcgc tggcggtgta ccacgagtcg      420

ctggagtcgt gggtggagaa ccgcaacaac acccgcgccc ggtccgtggt caagaaccag      480

tacattgccc tggagctgat gttcgtgcag aagctcccgt ccttcgcggt gtccggcgag      540

gaagtgccac tgttgcccat ctacgcccaa gcagccaacc tgcacctcct tctcctccgg      600

gacgtcagca tcttcgggaa ggagtggggc ctttcagcgt cagagatttc aaccttctac      660

aacaggcaag ttgagcgcac gcgcgactac tcggaccact gcgtcaagtg gtacaacacc      720

ggcctcaaca acctgcgtgg aacgaacgcc aagagctggg tccgctacaa ccagtttcga      780

aaggacatga ccctcatggt gctggacctt gtggccttgt tcccgtccta cgacaccctc      840

gtttatccga ttaagactac atctcaactt acccgcgagg tttacacaga cgccataggg      900

accgtgcatc ctaaccaggc gttcgcatcg acaacttggt acaacaacaa cgcgccctcg      960

ttctcagcca tcgaggccgc cgtgatccgt tcaccgcacc tcctggactt cctggagaag     1020

gttaccatct actccctctt gtctcgctgg agtaatactc agtacatgaa catgtgggga     1080

ggacatcgcc tcgaatctcg accgattggc ggcgcgctta acacatccac acagggctcc     1140

acgaacacca gcatcaaccc ggtgacgttg caattcactt cacgcgatgt ctatcggacc     1200

gagagctggg ctggcctgaa cctgttccta actcagcccg tgaacggtgt gcccagagtc     1260

gatttccact ggaaattcgt cactcatccc atcgccagcg acaacttcta ctacccaggc     1320

tacgccggta tcggcacaca gcttcaagac tccgagaacg aactgcctcc cgagactact     1380

ggccagccga actacgagag ttactcccat aggctttcgc acatcggcct aatctcagct     1440

tcgcatgtta aagcactcgt gtactcatgg acacacagaa gcgccgacag aacgaacacc     1500

attgagccaa actctatcac gcagatcccg ctggttaagg cgttcaactt gtcgagcggc     1560

gctgcggtcg tgcgcggacc tggattcacc ggtggcgaca ttctgcgccg caccaacaca     1620

ggaaccttcg gcgacatccg ggtgaacatc aacccgccgt ttgcacaacg ctatcgcgtc     1680

aggatacggt acgcatccac gacggacctc cagttccaca ccagcatcaa cgggaaggct     1740

atcaaccagg gaaactttag cgccacgatg aaccgtggtg aggacttgga ctacaagaca     1800

ttccggacgg tcggcttcac gacgcccttc agctttagcg acgtccagtc caccttcacc     1860

atcggagcat ggaacttcag tagcggcaac gaggtgtaca tcgaccgaat cgagttcgtc     1920

ccggttgagg tgacctacgg agccgaatac gacttcgaga agtga                     1965


<210>  17
<211>  610
<212>  PRT
<213>  Artificial

<220>
<223>  An amino acid sequence of the variant TIC2199_3 variant with the 
       initiating methionine removed and used to operably link to a 
       chloroplast transit peptide.

<400>  17

Ser Lys Tyr Lys Asn Val Ala Pro Phe Val Ser Ala Ser Thr Ile Gln 
1               5                   10                  15      


Thr Gly Ile Gly Ile Ala Gly Lys Ile Leu Gly Thr Leu Gly Val Pro 
            20                  25                  30          


Phe Ala Gly Gln Ile Ala Ser Leu Tyr Ser Phe Ile Leu Gly Glu Leu 
        35                  40                  45              


Trp Pro Lys Gly Lys Ser Gln Trp Glu Ile Phe Met Glu His Val Glu 
    50                  55                  60                  


Glu Ile Ile Asn Gln Lys Ile Ser Thr Tyr Ala Arg Asn Lys Ala Leu 
65                  70                  75                  80  


Ser Asp Leu Arg Gly Leu Gly Asp Ala Leu Ala Val Tyr His Glu Ser 
                85                  90                  95      


Leu Glu Ser Trp Val Glu Asn Arg Asn Asn Thr Arg Ala Arg Ser Val 
            100                 105                 110         


Val Lys Asn Gln Tyr Ile Ala Leu Glu Leu Met Phe Val Gln Lys Leu 
        115                 120                 125             


Pro Ser Phe Ala Val Ser Gly Glu Glu Val Pro Leu Leu Pro Ile Tyr 
    130                 135                 140                 


Ala Gln Ala Ala Asn Leu His Leu Leu Leu Leu Arg Asp Val Ser Ile 
145                 150                 155                 160 


Phe Gly Lys Glu Trp Gly Leu Ser Ala Ser Glu Ile Ser Thr Phe Tyr 
                165                 170                 175     


Asn Arg Gln Val Glu Arg Thr Arg Asp Tyr Ser Asp His Cys Val Lys 
            180                 185                 190         


Trp Tyr Asn Thr Gly Leu Asn Asn Leu Arg Gly Thr Asn Ala Lys Ser 
        195                 200                 205             


Trp Val Arg Tyr Asn Gln Phe Arg Lys Asp Met Thr Leu Met Val Leu 
    210                 215                 220                 


Asp Leu Val Ala Leu Phe Pro Ser Tyr Asp Thr Leu Val Tyr Pro Ile 
225                 230                 235                 240 


Lys Thr Thr Ser Gln Leu Thr Arg Glu Val Tyr Thr Asp Ala Ile Gly 
                245                 250                 255     


Thr Val His Pro Asn Gln Ala Phe Ala Ser Thr Thr Trp Tyr Asn Asn 
            260                 265                 270         


Asn Ala Pro Ser Phe Ser Ala Ile Glu Ala Ala Val Ile Arg Ser Pro 
        275                 280                 285             


His Leu Leu Asp Phe Leu Glu Lys Val Thr Ile Tyr Ser Leu Leu Ser 
    290                 295                 300                 


Arg Trp Ser Asn Thr Gln Tyr Met Asn Met Trp Gly Gly His Arg Leu 
305                 310                 315                 320 


Glu Ser Arg Pro Ile Gly Gly Ala Leu Asn Thr Ser Thr Gln Gly Ser 
                325                 330                 335     


Thr Asn Thr Ser Ile Asn Pro Val Thr Leu Gln Phe Thr Ser Arg Asp 
            340                 345                 350         


Val Tyr Arg Thr Glu Ser Trp Ala Gly Leu Asn Leu Phe Leu Thr Gln 
        355                 360                 365             


Pro Val Asn Gly Val Pro Arg Val Asp Phe His Trp Lys Phe Val Thr 
    370                 375                 380                 


His Pro Ile Ala Ser Asp Asn Phe Tyr Tyr Pro Gly Tyr Ala Gly Ile 
385                 390                 395                 400 


Gly Thr Gln Leu Gln Asp Ser Glu Asn Glu Leu Pro Pro Glu Thr Thr 
                405                 410                 415     


Gly Gln Pro Asn Tyr Glu Ser Tyr Ser His Arg Leu Ser His Ile Gly 
            420                 425                 430         


Leu Ile Ser Ala Ser His Val Lys Ala Leu Val Tyr Ser Trp Thr His 
        435                 440                 445             


Arg Ser Ala Asp Arg Thr Asn Thr Ile Glu Pro Asn Ser Ile Thr Gln 
    450                 455                 460                 


Ile Pro Leu Val Lys Ala Phe Asn Leu Ser Ser Gly Ala Ala Val Val 
465                 470                 475                 480 


Arg Gly Pro Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Thr Asn Thr 
                485                 490                 495     


Gly Thr Phe Gly Asp Ile Arg Val Asn Ile Asn Pro Pro Phe Ala Gln 
            500                 505                 510         


Arg Tyr Arg Val Arg Ile Arg Tyr Ala Ser Thr Thr Asp Leu Gln Phe 
        515                 520                 525             


His Thr Ser Ile Asn Gly Lys Ala Ile Asn Gln Gly Asn Phe Ser Ala 
    530                 535                 540                 


Thr Met Asn Arg Gly Glu Asp Leu Asp Tyr Lys Thr Phe Arg Thr Val 
545                 550                 555                 560 


Gly Phe Thr Thr Pro Phe Ser Phe Ser Asp Val Gln Ser Thr Phe Thr 
                565                 570                 575     


Ile Gly Ala Trp Asn Phe Ser Ser Gly Asn Glu Val Tyr Ile Asp Arg 
            580                 585                 590         


Ile Glu Phe Val Pro Val Glu Val Thr Tyr Gly Ala Glu Tyr Asp Phe 
        595                 600                 605             


Glu Lys 
    610 


<210>  18
<211>  1833
<212>  DNA
<213>  Artificial

<220>
<223>  A synthetic coding sequence encoding the TIC2199_3 variant with 
       the initiating methionine codon removed and used to operably link
       to a chloroplast transit peptide, and capable of use in a plant 
       cell.

<400>  18
tctaagtaca agaacgtcgc acccttcgtc tcggcttcta cgatccagac gggcattggc       60

atcgccggga agatactcgg cacactcggc gtcccgttcg ctggtcaaat cgcctcgctc      120

tactccttca tactcggtga actgtggccg aagggcaagt cgcagtggga aatcttcatg      180

gagcacgtgg aggagatcat caaccagaag ataagcacct acgcccgtaa caaggcgctg      240

agcgacctcc gtgggctggg cgatgcgctg gcggtgtacc acgagtcgct ggagtcgtgg      300

gtggagaacc gcaacaacac ccgcgcccgg tccgtggtca agaaccagta cattgccctg      360

gagctgatgt tcgtgcagaa gctcccgtcc ttcgcggtgt ccggcgagga agtgccactg      420

ttgcccatct acgcccaagc agccaacctg cacctccttc tcctccggga cgtcagcatc      480

ttcgggaagg agtggggcct ttcagcgtca gagatttcaa ccttctacaa caggcaagtt      540

gagcgcacgc gcgactactc ggaccactgc gtcaagtggt acaacaccgg cctcaacaac      600

ctgcgtggaa cgaacgccaa gagctgggtc cgctacaacc agtttcgaaa ggacatgacc      660

ctcatggtgc tggaccttgt ggccttgttc ccgtcctacg acaccctcgt ttatccgatt      720

aagactacat ctcaacttac ccgcgaggtt tacacagacg ccatagggac cgtgcatcct      780

aaccaggcgt tcgcatcgac aacttggtac aacaacaacg cgccctcgtt ctcagccatc      840

gaggccgccg tgatccgttc accgcacctc ctggacttcc tggagaaggt taccatctac      900

tccctcttgt ctcgctggag taatactcag tacatgaaca tgtggggagg acatcgcctc      960

gaatctcgac cgattggcgg cgcgcttaac acatccacac agggctccac gaacaccagc     1020

atcaacccgg tgacgttgca attcacttca cgcgatgtct atcggaccga gagctgggct     1080

ggcctgaacc tgttcctaac tcagcccgtg aacggtgtgc ccagagtcga tttccactgg     1140

aaattcgtca ctcatcccat cgccagcgac aacttctact acccaggcta cgccggtatc     1200

ggcacacagc ttcaagactc cgagaacgaa ctgcctcccg agactactgg ccagccgaac     1260

tacgagagtt actcccatag gctttcgcac atcggcctaa tctcagcttc gcatgttaaa     1320

gcactcgtgt actcatggac acacagaagc gccgacagaa cgaacaccat tgagccaaac     1380

tctatcacgc agatcccgct ggttaaggcg ttcaacttgt cgagcggcgc tgcggtcgtg     1440

cgcggacctg gattcaccgg tggcgacatt ctgcgccgca ccaacacagg aaccttcggc     1500

gacatccggg tgaacatcaa cccgccgttt gcacaacgct atcgcgtcag gatacggtac     1560

gcatccacga cggacctcca gttccacacc agcatcaacg ggaaggctat caaccaggga     1620

aactttagcg ccacgatgaa ccgtggtgag gacttggact acaagacatt ccggacggtc     1680

ggcttcacga cgcccttcag ctttagcgac gtccagtcca ccttcaccat cggagcatgg     1740

aacttcagta gcggcaacga ggtgtacatc gaccgaatcg agttcgtccc ggttgaggtg     1800

acctacggag ccgaatacga cttcgagaag tga                                  1833


