               SEQUENCE LISTING

<110> Isobionics B.V.

<120> Recombinant manufacture of C-20 terpenoid alcohols

<130> B210230PC

<150> 21184067.3
<151> 2021-07-06

<160> 58

<170> BiSSAP 1.3.6

<210> 1
<211> 1893
<212> DNA
<213> Cupressus gigantea


<400> 1
atggcagcac ttagtttttc taccatctcc accactgcca actatgcaat tcctaagctg      60

ccatcttcaa atcttcaagg gcggtccaga gatacaaaat accatgtctt gataagatct     120

gcaggggcct ctaatttcaa cttcaatgga agaaagaagt tcaatccaag aacacatcag     180

aaagtcaaat ctttgagtgt tgaagattcc tccaatgtac ttattaaggc tgagaaagag     240

aacagagaga aaaaatcatt tggttcgatg tgcatagatg atgatattac aaagataaaa     300

atgttgttct cggaaattaa aagaagatat tcatctcttt ctgcttatga tacagtgcac     360

ggtgcttatc ctatcaattt gattcttggc ctctcaatgg taaaccactt ggagagcttg     420

ggtatagcaa gacatttcaa acttgagata aaagaggttc tagatgatgt ctatagattt     480

tggatagaga atgaaatggt tgaaggaatg ccatcagcat cagacataat gaccagttct     540

atcagtttca ggatcttgcg gtggaatgga tatgacgtgt ctccagatgt ctttttcagt     600

tacctgaggg atagtgactt cctactattt ttagaaaata gtgaccaagc tactatagca     660

ttgctgaatt tatacaaggc atctcagatg atgttcccag gcgaaagaat tcttgaagaa     720

gcaaaattgt tctcccaaaa ttatcttgaa aatatcaaga tgggcaatca aagtggagct     780

ctcaaagaca ttgaagcaga ggttaagcat gcactggatg tcccttggat ggctaatttg     840

gagagaatag aacatctgcg atacatgaaa gcatttgctt ttgacaatat ttggattgga     900

gagacctctt ctaggatccc atttacagga aaggatttat ttttatcttt tgccaaacaa     960

gacttcaata tctgccaagc agctcaacaa gaggatttga aggcgttgga aaaatggagt    1020

gtagactcta aacttggtga cctacacttt gctagacaaa agcttgtagc ctgctatttc    1080

tctgccgcct caatactttt tagccctgaa atgtctgcta ctcggattgt gtggactaaa    1140

aatgctgttc tcattacact aatggatgac ttttatgatg tggagggttc catygaagat    1200

attcaatcct ttgttgaagc ggttaagaga tgggacccaa tagttttatg taattgttca    1260

gctaatgtta aaattttatt ctctgctatt tataacactg tgaatgatat tgctcaagat    1320

atatggattt tccagggctg ggacattagc actcagttaa gagaaatttg gtacgaactg    1380

gcaatctcaa tgatgaagga ggctgaatgg accaaaactg gatttatacc atccttggaa    1440

gaatacatgg aaaatgggag aacatcaatt gccttggaac caattatttt tacatcacta    1500

ttttttattg gccctaagct ttccgagcaa atgatccacc atcacgagta taagaggctt    1560

ttgcaactca tgaatacttg tgggcgcctt ttgaatgaca ttcagagcga caagagggag    1620

atgaagcaag gaaagctcac ctctgtatca ttgttcgtga aagaataccc aattgaggat    1680

gctactaagt ggattagact cactgtaagt gaaaacacac aaaatatact caaaaaaata    1740

ttgcaaccaa gtgagatccc tcgtgaatgc aagcagatat tttggaatat ggtcaaaatt    1800

atccaactat tctgcctcca cagtgatgaa ttcacatctc ctaccacaat gcttgaacat    1860

atgaaggcag ttctttttta tcctgtttta taa                                 1893


<210> 2
<211> 1896
<212> DNA
<213> Cupressus gigantea


<400> 2
atggcagcac ttagtttttc taccatctcc accactgcca actatgcaat tcctaagctg      60

ccatcttcaa atcttcaagg gcggtccaga gatacaaaat accatgtctt gataagatct     120

gcaggggcct ctaatttcaa cttcaatgga agaaagaagt tcaatccaag aacacatcag     180

aaagtcaaat ctttgagtgt tgaagattcc tccaatgtac ttattaaggc tgagaaagag     240

aacagagaga aaaaatcatt tggttcgatg tgcatagacg ataatattac aaggataaat     300

atgttgttct tggaaattaa gagaagatat tcatctcttt ctgcttatga tacagtgcac     360

ggtgcttatc ctatcaattt gattcttggc ctctcaatgg taaatcattt ggagagcttg     420

ggtatagcaa gacatttcaa acttgagata aaagaggttc tagatgatgt ctatagattt     480

tggatagaga atgaaatggt taaaggaatg ccatcagcat cagacataat gaccagttct     540

atcagtttca agatcttgcg gtggaatgga tatgacgtgt ctccagatgt ctttttcagt     600

tacctgaggg atagtgactt cctaccattt ctagaaaata gtggccaagc tactatggca     660

ttgctgaatt tatacaaggc atctcagatg atgttcccag gggaaagaat tcttgaagaa     720

gcaaaatcgt tctcccaaaa ttatcttgaa aatatcaagg tgggcgatca aagtggagct     780

ctcaaagata ttgaagcaga ggttaagcat gcactggatg ttccttggat ggctggtttg     840

gagagaatag aacatctgcg atacatgaaa gcatttgctt ttgatgatat ttggattgga     900

gagacctctt ctaggatccc atttacagga aaggatttat ttttatcttt agccaaacaa     960

gacttcaata tctgccaaga agctcaacaa gaggatttga aagcgttgga aaaatggagt    1020

gtagactcta aacttggtga cctacacttt gctagacaaa agcttgtagc ctgctatttc    1080

tctgccgcct caacactttt tagccctgaa atgtctacta ctcggattgt gtggactaaa    1140

aatgctgttc tcactactct aatggatgac ttttatgatg tggagggttc cattgaagat    1200

attcaatcct ttgttgaagc agttaagaga tgggacccaa tagttttatg taattgttca    1260

gctaatgtga aaaaattatt ctctgctatt tataacactg tgaatgatat tgctcaagat    1320

atatggattt tccagggctg ggacattagc actcagttaa gagaaatttg gtacgaactg    1380

gcaatctcaa tgatgaagga ggctgaatgg accaaaactg gatttatacc atcgctggaa    1440

gaatacatgg aaaatgggag aacgtcaatt gccttggaac caattatttt tacatcacta    1500

ttttttcttg gccctaagct ttccgagcaa atgatccacg agtataagag acttatgcaa    1560

ctcctgaata cttgtgggcg ccttttgaat gacagtcaga gctacaagag ggagataaag    1620

caaggaaagc tcaactcttt atcattgttc gtgaaagaat atcccgcaac atctattgag    1680

gatgctactg agtggattag actcactgta agtgaaagca gacaaaatat actcagaaat    1740

ttattgcaac caagtgagat ccctcgtgaa tgcaagcaga tattttggaa tatggtcaaa    1800

attatccaac tattctacct ccacagtgat gaattcacat ctcctactgc aatgcttgaa    1860

catatgcaag cagttctttt taatcctgtt ttataa                              1896


<210> 3
<211> 630
<212> PRT
<213> Cupressus gigantea


<220> 
<221> UNSURE
<222> 398

<400> 3
Met Ala Ala Leu Ser Phe Ser Thr Ile Ser Thr Thr Ala Asn Tyr Ala 
1               5                   10                  15      
Ile Pro Lys Leu Pro Ser Ser Asn Leu Gln Gly Arg Ser Arg Asp Thr 
            20                  25                  30          
Lys Tyr His Val Leu Ile Arg Ser Ala Gly Ala Ser Asn Phe Asn Phe 
        35                  40                  45              
Asn Gly Arg Lys Lys Phe Asn Pro Arg Thr His Gln Lys Val Lys Ser 
    50                  55                  60                  
Leu Ser Val Glu Asp Ser Ser Asn Val Leu Ile Lys Ala Glu Lys Glu 
65                  70                  75                  80  
Asn Arg Glu Lys Lys Ser Phe Gly Ser Met Cys Ile Asp Asp Asp Ile 
                85                  90                  95      
Thr Lys Ile Lys Met Leu Phe Ser Glu Ile Lys Arg Arg Tyr Ser Ser 
            100                 105                 110         
Leu Ser Ala Tyr Asp Thr Val His Gly Ala Tyr Pro Ile Asn Leu Ile 
        115                 120                 125             
Leu Gly Leu Ser Met Val Asn His Leu Glu Ser Leu Gly Ile Ala Arg 
    130                 135                 140                 
His Phe Lys Leu Glu Ile Lys Glu Val Leu Asp Asp Val Tyr Arg Phe 
145                 150                 155                 160 
Trp Ile Glu Asn Glu Met Val Glu Gly Met Pro Ser Ala Ser Asp Ile 
                165                 170                 175     
Met Thr Ser Ser Ile Ser Phe Arg Ile Leu Arg Trp Asn Gly Tyr Asp 
            180                 185                 190         
Val Ser Pro Asp Val Phe Phe Ser Tyr Leu Arg Asp Ser Asp Phe Leu 
        195                 200                 205             
Leu Phe Leu Glu Asn Ser Asp Gln Ala Thr Ile Ala Leu Leu Asn Leu 
    210                 215                 220                 
Tyr Lys Ala Ser Gln Met Met Phe Pro Gly Glu Arg Ile Leu Glu Glu 
225                 230                 235                 240 
Ala Lys Leu Phe Ser Gln Asn Tyr Leu Glu Asn Ile Lys Met Gly Asn 
                245                 250                 255     
Gln Ser Gly Ala Leu Lys Asp Ile Glu Ala Glu Val Lys His Ala Leu 
            260                 265                 270         
Asp Val Pro Trp Met Ala Asn Leu Glu Arg Ile Glu His Leu Arg Tyr 
        275                 280                 285             
Met Lys Ala Phe Ala Phe Asp Asn Ile Trp Ile Gly Glu Thr Ser Ser 
    290                 295                 300                 
Arg Ile Pro Phe Thr Gly Lys Asp Leu Phe Leu Ser Phe Ala Lys Gln 
305                 310                 315                 320 
Asp Phe Asn Ile Cys Gln Ala Ala Gln Gln Glu Asp Leu Lys Ala Leu 
                325                 330                 335     
Glu Lys Trp Ser Val Asp Ser Lys Leu Gly Asp Leu His Phe Ala Arg 
            340                 345                 350         
Gln Lys Leu Val Ala Cys Tyr Phe Ser Ala Ala Ser Ile Leu Phe Ser 
        355                 360                 365             
Pro Glu Met Ser Ala Thr Arg Ile Val Trp Thr Lys Asn Ala Val Leu 
    370                 375                 380                 
Ile Thr Leu Met Asp Asp Phe Tyr Asp Val Glu Gly Ser Ile Glu Asp 
385                 390                 395                 400 
Ile Gln Ser Phe Val Glu Ala Val Lys Arg Trp Asp Pro Ile Val Leu 
                405                 410                 415     
Cys Asn Cys Ser Ala Asn Val Lys Ile Leu Phe Ser Ala Ile Tyr Asn 
            420                 425                 430         
Thr Val Asn Asp Ile Ala Gln Asp Ile Trp Ile Phe Gln Gly Trp Asp 
        435                 440                 445             
Ile Ser Thr Gln Leu Arg Glu Ile Trp Tyr Glu Leu Ala Ile Ser Met 
    450                 455                 460                 
Met Lys Glu Ala Glu Trp Thr Lys Thr Gly Phe Ile Pro Ser Leu Glu 
465                 470                 475                 480 
Glu Tyr Met Glu Asn Gly Arg Thr Ser Ile Ala Leu Glu Pro Ile Ile 
                485                 490                 495     
Phe Thr Ser Leu Phe Phe Ile Gly Pro Lys Leu Ser Glu Gln Met Ile 
            500                 505                 510         
His His His Glu Tyr Lys Arg Leu Leu Gln Leu Met Asn Thr Cys Gly 
        515                 520                 525             
Arg Leu Leu Asn Asp Ile Gln Ser Asp Lys Arg Glu Met Lys Gln Gly 
    530                 535                 540                 
Lys Leu Thr Ser Val Ser Leu Phe Val Lys Glu Tyr Pro Ile Glu Asp 
545                 550                 555                 560 
Ala Thr Lys Trp Ile Arg Leu Thr Val Ser Glu Asn Thr Gln Asn Ile 
                565                 570                 575     
Leu Lys Lys Ile Leu Gln Pro Ser Glu Ile Pro Arg Glu Cys Lys Gln 
            580                 585                 590         
Ile Phe Trp Asn Met Val Lys Ile Ile Gln Leu Phe Cys Leu His Ser 
        595                 600                 605             
Asp Glu Phe Thr Ser Pro Thr Thr Met Leu Glu His Met Lys Ala Val 
    610                 615                 620                 
Leu Phe Tyr Pro Val Leu 
625                 630 

<210> 4
<211> 631
<212> PRT
<213> Cupressus gigantea


<400> 4
Met Ala Ala Leu Ser Phe Ser Thr Ile Ser Thr Thr Ala Asn Tyr Ala 
1               5                   10                  15      
Ile Pro Lys Leu Pro Ser Ser Asn Leu Gln Gly Arg Ser Arg Asp Thr 
            20                  25                  30          
Lys Tyr His Val Leu Ile Arg Ser Ala Gly Ala Ser Asn Phe Asn Phe 
        35                  40                  45              
Asn Gly Arg Lys Lys Phe Asn Pro Arg Thr His Gln Lys Val Lys Ser 
    50                  55                  60                  
Leu Ser Val Glu Asp Ser Ser Asn Val Leu Ile Lys Ala Glu Lys Glu 
65                  70                  75                  80  
Asn Arg Glu Lys Lys Ser Phe Gly Ser Met Cys Ile Asp Asp Asn Ile 
                85                  90                  95      
Thr Arg Ile Asn Met Leu Phe Leu Glu Ile Lys Arg Arg Tyr Ser Ser 
            100                 105                 110         
Leu Ser Ala Tyr Asp Thr Val His Gly Ala Tyr Pro Ile Asn Leu Ile 
        115                 120                 125             
Leu Gly Leu Ser Met Val Asn His Leu Glu Ser Leu Gly Ile Ala Arg 
    130                 135                 140                 
His Phe Lys Leu Glu Ile Lys Glu Val Leu Asp Asp Val Tyr Arg Phe 
145                 150                 155                 160 
Trp Ile Glu Asn Glu Met Val Lys Gly Met Pro Ser Ala Ser Asp Ile 
                165                 170                 175     
Met Thr Ser Ser Ile Ser Phe Lys Ile Leu Arg Trp Asn Gly Tyr Asp 
            180                 185                 190         
Val Ser Pro Asp Val Phe Phe Ser Tyr Leu Arg Asp Ser Asp Phe Leu 
        195                 200                 205             
Pro Phe Leu Glu Asn Ser Gly Gln Ala Thr Met Ala Leu Leu Asn Leu 
    210                 215                 220                 
Tyr Lys Ala Ser Gln Met Met Phe Pro Gly Glu Arg Ile Leu Glu Glu 
225                 230                 235                 240 
Ala Lys Ser Phe Ser Gln Asn Tyr Leu Glu Asn Ile Lys Val Gly Asp 
                245                 250                 255     
Gln Ser Gly Ala Leu Lys Asp Ile Glu Ala Glu Val Lys His Ala Leu 
            260                 265                 270         
Asp Val Pro Trp Met Ala Gly Leu Glu Arg Ile Glu His Leu Arg Tyr 
        275                 280                 285             
Met Lys Ala Phe Ala Phe Asp Asp Ile Trp Ile Gly Glu Thr Ser Ser 
    290                 295                 300                 
Arg Ile Pro Phe Thr Gly Lys Asp Leu Phe Leu Ser Leu Ala Lys Gln 
305                 310                 315                 320 
Asp Phe Asn Ile Cys Gln Glu Ala Gln Gln Glu Asp Leu Lys Ala Leu 
                325                 330                 335     
Glu Lys Trp Ser Val Asp Ser Lys Leu Gly Asp Leu His Phe Ala Arg 
            340                 345                 350         
Gln Lys Leu Val Ala Cys Tyr Phe Ser Ala Ala Ser Thr Leu Phe Ser 
        355                 360                 365             
Pro Glu Met Ser Thr Thr Arg Ile Val Trp Thr Lys Asn Ala Val Leu 
    370                 375                 380                 
Thr Thr Leu Met Asp Asp Phe Tyr Asp Val Glu Gly Ser Ile Glu Asp 
385                 390                 395                 400 
Ile Gln Ser Phe Val Glu Ala Val Lys Arg Trp Asp Pro Ile Val Leu 
                405                 410                 415     
Cys Asn Cys Ser Ala Asn Val Lys Lys Leu Phe Ser Ala Ile Tyr Asn 
            420                 425                 430         
Thr Val Asn Asp Ile Ala Gln Asp Ile Trp Ile Phe Gln Gly Trp Asp 
        435                 440                 445             
Ile Ser Thr Gln Leu Arg Glu Ile Trp Tyr Glu Leu Ala Ile Ser Met 
    450                 455                 460                 
Met Lys Glu Ala Glu Trp Thr Lys Thr Gly Phe Ile Pro Ser Leu Glu 
465                 470                 475                 480 
Glu Tyr Met Glu Asn Gly Arg Thr Ser Ile Ala Leu Glu Pro Ile Ile 
                485                 490                 495     
Phe Thr Ser Leu Phe Phe Leu Gly Pro Lys Leu Ser Glu Gln Met Ile 
            500                 505                 510         
His Glu Tyr Lys Arg Leu Met Gln Leu Leu Asn Thr Cys Gly Arg Leu 
        515                 520                 525             
Leu Asn Asp Ser Gln Ser Tyr Lys Arg Glu Ile Lys Gln Gly Lys Leu 
    530                 535                 540                 
Asn Ser Leu Ser Leu Phe Val Lys Glu Tyr Pro Ala Thr Ser Ile Glu 
545                 550                 555                 560 
Asp Ala Thr Glu Trp Ile Arg Leu Thr Val Ser Glu Ser Arg Gln Asn 
                565                 570                 575     
Ile Leu Arg Asn Leu Leu Gln Pro Ser Glu Ile Pro Arg Glu Cys Lys 
            580                 585                 590         
Gln Ile Phe Trp Asn Met Val Lys Ile Ile Gln Leu Phe Tyr Leu His 
        595                 600                 605             
Ser Asp Glu Phe Thr Ser Pro Thr Ala Met Leu Glu His Met Gln Ala 
    610                 615                 620                 
Val Leu Phe Asn Pro Val Leu 
625                 630     

<210> 5
<211> 549
<212> PRT
<213> Artificial Sequence


<220> 
<223> truncated protein

<220> 
<221> UNSURE
<222> 317

<400> 5
Met Glu Lys Lys Ser Phe Gly Ser Met Cys Ile Asp Asp Asp Ile Thr 
1               5                   10                  15      
Lys Ile Lys Met Leu Phe Ser Glu Ile Lys Arg Arg Tyr Ser Ser Leu 
            20                  25                  30          
Ser Ala Tyr Asp Thr Val His Gly Ala Tyr Pro Ile Asn Leu Ile Leu 
        35                  40                  45              
Gly Leu Ser Met Val Asn His Leu Glu Ser Leu Gly Ile Ala Arg His 
    50                  55                  60                  
Phe Lys Leu Glu Ile Lys Glu Val Leu Asp Asp Val Tyr Arg Phe Trp 
65                  70                  75                  80  
Ile Glu Asn Glu Met Val Glu Gly Met Pro Ser Ala Ser Asp Ile Met 
                85                  90                  95      
Thr Ser Ser Ile Ser Phe Arg Ile Leu Arg Trp Asn Gly Tyr Asp Val 
            100                 105                 110         
Ser Pro Asp Val Phe Phe Ser Tyr Leu Arg Asp Ser Asp Phe Leu Leu 
        115                 120                 125             
Phe Leu Glu Asn Ser Asp Gln Ala Thr Ile Ala Leu Leu Asn Leu Tyr 
    130                 135                 140                 
Lys Ala Ser Gln Met Met Phe Pro Gly Glu Arg Ile Leu Glu Glu Ala 
145                 150                 155                 160 
Lys Leu Phe Ser Gln Asn Tyr Leu Glu Asn Ile Lys Met Gly Asn Gln 
                165                 170                 175     
Ser Gly Ala Leu Lys Asp Ile Glu Ala Glu Val Lys His Ala Leu Asp 
            180                 185                 190         
Val Pro Trp Met Ala Asn Leu Glu Arg Ile Glu His Leu Arg Tyr Met 
        195                 200                 205             
Lys Ala Phe Ala Phe Asp Asn Ile Trp Ile Gly Glu Thr Ser Ser Arg 
    210                 215                 220                 
Ile Pro Phe Thr Gly Lys Asp Leu Phe Leu Ser Phe Ala Lys Gln Asp 
225                 230                 235                 240 
Phe Asn Ile Cys Gln Ala Ala Gln Gln Glu Asp Leu Lys Ala Leu Glu 
                245                 250                 255     
Lys Trp Ser Val Asp Ser Lys Leu Gly Asp Leu His Phe Ala Arg Gln 
            260                 265                 270         
Lys Leu Val Ala Cys Tyr Phe Ser Ala Ala Ser Ile Leu Phe Ser Pro 
        275                 280                 285             
Glu Met Ser Ala Thr Arg Ile Val Trp Thr Lys Asn Ala Val Leu Ile 
    290                 295                 300                 
Thr Leu Met Asp Asp Phe Tyr Asp Val Glu Gly Ser Ile Glu Asp Ile 
305                 310                 315                 320 
Gln Ser Phe Val Glu Ala Val Lys Arg Trp Asp Pro Ile Val Leu Cys 
                325                 330                 335     
Asn Cys Ser Ala Asn Val Lys Ile Leu Phe Ser Ala Ile Tyr Asn Thr 
            340                 345                 350         
Val Asn Asp Ile Ala Gln Asp Ile Trp Ile Phe Gln Gly Trp Asp Ile 
        355                 360                 365             
Ser Thr Gln Leu Arg Glu Ile Trp Tyr Glu Leu Ala Ile Ser Met Met 
    370                 375                 380                 
Lys Glu Ala Glu Trp Thr Lys Thr Gly Phe Ile Pro Ser Leu Glu Glu 
385                 390                 395                 400 
Tyr Met Glu Asn Gly Arg Thr Ser Ile Ala Leu Glu Pro Ile Ile Phe 
                405                 410                 415     
Thr Ser Leu Phe Phe Ile Gly Pro Lys Leu Ser Glu Gln Met Ile His 
            420                 425                 430         
His His Glu Tyr Lys Arg Leu Leu Gln Leu Met Asn Thr Cys Gly Arg 
        435                 440                 445             
Leu Leu Asn Asp Ile Gln Ser Asp Lys Arg Glu Met Lys Gln Gly Lys 
    450                 455                 460                 
Leu Thr Ser Val Ser Leu Phe Val Lys Glu Tyr Pro Ile Glu Asp Ala 
465                 470                 475                 480 
Thr Lys Trp Ile Arg Leu Thr Val Ser Glu Asn Thr Gln Asn Ile Leu 
                485                 490                 495     
Lys Lys Ile Leu Gln Pro Ser Glu Ile Pro Arg Glu Cys Lys Gln Ile 
            500                 505                 510         
Phe Trp Asn Met Val Lys Ile Ile Gln Leu Phe Cys Leu His Ser Asp 
        515                 520                 525             
Glu Phe Thr Ser Pro Thr Thr Met Leu Glu His Met Lys Ala Val Leu 
    530                 535                 540                 
Phe Tyr Pro Val Leu 
545                 

<210> 6
<211> 550
<212> PRT
<213> Artificial Sequence


<220> 
<223> truncated protein

<400> 6
Met Glu Asn Lys Ser Phe Gly Ser Met Cys Ile Asp Asp Asn Ile Thr 
1               5                   10                  15      
Arg Ile Asn Met Leu Phe Leu Glu Ile Lys Arg Arg Tyr Ser Ser Leu 
            20                  25                  30          
Ser Ala Tyr Asp Thr Val His Gly Ala Tyr Pro Ile Asn Leu Ile Leu 
        35                  40                  45              
Gly Leu Ser Met Val Asn His Leu Glu Ser Leu Gly Ile Ala Arg His 
    50                  55                  60                  
Phe Lys Leu Glu Ile Lys Glu Val Leu Asp Asp Val Tyr Arg Phe Trp 
65                  70                  75                  80  
Ile Glu Asn Glu Met Val Lys Gly Met Pro Ser Ala Ser Asp Ile Met 
                85                  90                  95      
Thr Ser Ser Ile Ser Phe Lys Ile Leu Arg Trp Asn Gly Tyr Asp Val 
            100                 105                 110         
Ser Pro Asp Val Phe Phe Ser Tyr Leu Arg Asp Ser Asp Phe Leu Pro 
        115                 120                 125             
Phe Leu Glu Asn Ser Gly Gln Ala Thr Met Ala Leu Leu Asn Leu Tyr 
    130                 135                 140                 
Lys Ala Ser Gln Met Met Phe Pro Gly Glu Arg Ile Leu Glu Glu Ala 
145                 150                 155                 160 
Lys Ser Phe Ser Gln Asn Tyr Leu Glu Asn Ile Lys Val Gly Asp Gln 
                165                 170                 175     
Ser Gly Ala Leu Lys Asp Ile Glu Ala Glu Val Lys His Ala Leu Asp 
            180                 185                 190         
Val Pro Trp Met Ala Gly Leu Glu Arg Ile Glu His Leu Arg Tyr Met 
        195                 200                 205             
Lys Ala Phe Ala Phe Asp Asp Ile Trp Ile Gly Glu Thr Ser Ser Arg 
    210                 215                 220                 
Ile Pro Phe Thr Gly Lys Asp Leu Phe Leu Ser Leu Ala Lys Gln Asp 
225                 230                 235                 240 
Phe Asn Ile Cys Gln Glu Ala Gln Gln Glu Asp Leu Lys Ala Leu Glu 
                245                 250                 255     
Lys Trp Ser Val Asp Ser Lys Leu Gly Asp Leu His Phe Ala Arg Gln 
            260                 265                 270         
Lys Leu Val Ala Cys Tyr Phe Ser Ala Ala Ser Thr Leu Phe Ser Pro 
        275                 280                 285             
Glu Met Ser Thr Thr Arg Ile Val Trp Thr Lys Asn Ala Val Leu Thr 
    290                 295                 300                 
Thr Leu Met Asp Asp Phe Tyr Asp Val Glu Gly Ser Ile Glu Asp Ile 
305                 310                 315                 320 
Gln Ser Phe Val Glu Ala Val Lys Arg Trp Asp Pro Ile Val Leu Cys 
                325                 330                 335     
Asn Cys Ser Ala Asn Val Lys Lys Leu Phe Ser Ala Ile Tyr Asn Thr 
            340                 345                 350         
Val Asn Asp Ile Ala Gln Asp Ile Trp Ile Phe Gln Gly Trp Asp Ile 
        355                 360                 365             
Ser Thr Gln Leu Arg Glu Ile Trp Tyr Glu Leu Ala Ile Ser Met Met 
    370                 375                 380                 
Lys Glu Ala Glu Trp Thr Lys Thr Gly Phe Ile Pro Ser Leu Glu Glu 
385                 390                 395                 400 
Tyr Met Glu Asn Gly Arg Thr Ser Ile Ala Leu Glu Pro Ile Ile Phe 
                405                 410                 415     
Thr Ser Leu Phe Phe Leu Gly Pro Lys Leu Ser Glu Gln Met Ile His 
            420                 425                 430         
Glu Tyr Lys Arg Leu Met Gln Leu Leu Asn Thr Cys Gly Arg Leu Leu 
        435                 440                 445             
Asn Asp Ser Gln Ser Tyr Lys Arg Glu Ile Lys Gln Gly Lys Leu Thr 
    450                 455                 460                 
Ser Leu Ser Leu Phe Val Lys Glu Tyr Pro Ala His Leu Ile Glu Asp 
465                 470                 475                 480 
Ala Thr Glu Trp Ile Arg Leu Thr Val Ser Glu Ser Arg Gln Asn Ile 
                485                 490                 495     
Leu Arg Asn Leu Leu Gln Pro Ser Glu Ile Pro Arg Glu Cys Lys Gln 
            500                 505                 510         
Ile Phe Trp Asn Met Val Lys Ile Ile Gln Leu Phe Tyr Leu His Ser 
        515                 520                 525             
Asp Glu Phe Thr Ser Pro Thr Ala Met Leu Glu His Met Gln Ala Val 
    530                 535                 540                 
Leu Phe Asn Pro Val Leu 
545                 550 

<210> 7
<211> 550
<212> PRT
<213> Artificial Sequence


<220> 
<223> truncated protein

<400> 7
Met Glu Lys Lys Ser Phe Gly Ser Met Cys Ile Asp Asp Asn Ile Thr 
1               5                   10                  15      
Arg Ile Asn Met Leu Phe Leu Glu Ile Lys Arg Arg Tyr Ser Ser Leu 
            20                  25                  30          
Ser Ala Tyr Asp Thr Val His Gly Ala Tyr Pro Ile Asn Leu Ile Leu 
        35                  40                  45              
Gly Leu Ser Met Val Asn His Leu Glu Ser Leu Gly Ile Ala Arg His 
    50                  55                  60                  
Phe Lys Leu Glu Ile Lys Glu Val Leu Asp Asp Val Tyr Arg Phe Trp 
65                  70                  75                  80  
Ile Glu Asn Glu Met Val Lys Gly Met Pro Ser Ala Ser Asp Ile Met 
                85                  90                  95      
Thr Ser Ser Ile Ser Phe Lys Ile Leu Arg Trp Asn Gly Tyr Asp Val 
            100                 105                 110         
Ser Pro Asp Val Phe Phe Ser Tyr Leu Arg Asp Ser Asp Phe Leu Pro 
        115                 120                 125             
Phe Leu Glu Asn Ser Gly Gln Ala Thr Met Ala Leu Leu Asn Leu Tyr 
    130                 135                 140                 
Lys Ala Ser Gln Met Met Phe Pro Gly Glu Arg Ile Leu Glu Glu Ala 
145                 150                 155                 160 
Lys Ser Phe Ser Gln Asn Tyr Leu Glu Asn Ile Lys Val Gly Asp Gln 
                165                 170                 175     
Ser Gly Ala Leu Lys Asp Ile Glu Ala Glu Val Lys His Ala Leu Asp 
            180                 185                 190         
Val Pro Trp Met Ala Gly Leu Glu Arg Ile Glu His Leu Arg Tyr Met 
        195                 200                 205             
Lys Ala Phe Ala Phe Asp Asp Ile Trp Ile Gly Glu Thr Ser Ser Arg 
    210                 215                 220                 
Ile Pro Phe Thr Gly Lys Asp Leu Phe Leu Ser Leu Ala Lys Gln Asp 
225                 230                 235                 240 
Phe Asn Ile Cys Gln Glu Ala Gln Gln Glu Asp Leu Lys Ala Leu Glu 
                245                 250                 255     
Lys Trp Ser Val Asp Ser Lys Leu Gly Asp Leu His Phe Ala Arg Gln 
            260                 265                 270         
Lys Leu Val Ala Cys Tyr Phe Ser Ala Ala Ser Thr Leu Phe Ser Pro 
        275                 280                 285             
Glu Met Ser Thr Thr Arg Ile Val Trp Thr Lys Asn Ala Val Leu Thr 
    290                 295                 300                 
Thr Leu Met Asp Asp Phe Tyr Asp Val Glu Gly Ser Ile Glu Asp Ile 
305                 310                 315                 320 
Gln Ser Phe Val Glu Ala Val Lys Arg Trp Asp Pro Ile Val Leu Cys 
                325                 330                 335     
Asn Cys Ser Ala Asn Val Lys Lys Leu Phe Ser Ala Ile Tyr Asn Thr 
            340                 345                 350         
Val Asn Asp Ile Ala Gln Asp Ile Trp Ile Phe Gln Gly Trp Asp Ile 
        355                 360                 365             
Ser Thr Gln Leu Arg Glu Ile Trp Tyr Glu Leu Ala Ile Ser Met Met 
    370                 375                 380                 
Lys Glu Ala Glu Trp Thr Lys Thr Gly Phe Ile Pro Ser Leu Glu Glu 
385                 390                 395                 400 
Tyr Met Glu Asn Gly Arg Thr Ser Ile Ala Leu Glu Pro Ile Ile Phe 
                405                 410                 415     
Thr Ser Leu Phe Phe Leu Gly Pro Lys Leu Ser Glu Gln Met Ile His 
            420                 425                 430         
Glu Tyr Lys Arg Leu Met Gln Leu Leu Asn Thr Cys Gly Arg Leu Leu 
        435                 440                 445             
Asn Asp Ser Gln Ser Tyr Lys Arg Glu Ile Lys Gln Gly Lys Leu Asn 
    450                 455                 460                 
Ser Leu Ser Leu Phe Val Lys Glu Tyr Pro Ala Thr Ser Ile Glu Asp 
465                 470                 475                 480 
Ala Thr Glu Trp Ile Arg Leu Thr Val Ser Glu Ser Arg Gln Asn Ile 
                485                 490                 495     
Leu Arg Asn Leu Leu Gln Pro Ser Glu Ile Pro Arg Glu Cys Lys Gln 
            500                 505                 510         
Ile Phe Trp Asn Met Val Lys Ile Ile Gln Leu Phe Tyr Leu His Ser 
        515                 520                 525             
Asp Glu Phe Thr Ser Pro Thr Ala Met Leu Glu His Met Gln Ala Val 
    530                 535                 540                 
Leu Phe Asn Pro Val Leu 
545                 550 

<210> 8
<211> 921
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 8
Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      
Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          
Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              
Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  
His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  
Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      
Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         
Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             
Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 
Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 
Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     
Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         
Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             
Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 
Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 
Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     
Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         
Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             
Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 
Leu Lys Ser Tyr Glu Glu Glu Leu Val Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 
Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     
Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         
Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Gly 
        355                 360                 365             
Gly Gly Ala Ala Met Glu Lys Lys Ser Phe Gly Ser Met Cys Ile Asp 
    370                 375                 380                 
Asp Asp Ile Thr Lys Ile Lys Met Leu Phe Ser Glu Ile Lys Arg Arg 
385                 390                 395                 400 
Tyr Ser Ser Leu Ser Ala Tyr Asp Thr Val His Gly Ala Tyr Pro Ile 
                405                 410                 415     
Asn Leu Ile Leu Gly Leu Ser Met Val Asn His Leu Glu Ser Leu Gly 
            420                 425                 430         
Ile Ala Arg His Phe Lys Leu Glu Ile Lys Glu Val Leu Asp Asp Val 
        435                 440                 445             
Tyr Arg Phe Trp Ile Glu Asn Glu Met Val Glu Gly Met Pro Ser Ala 
    450                 455                 460                 
Ser Asp Ile Met Thr Ser Ser Ile Ser Phe Arg Ile Leu Arg Trp Asn 
465                 470                 475                 480 
Gly Tyr Asp Val Ser Pro Asp Val Phe Phe Ser Tyr Leu Arg Asp Ser 
                485                 490                 495     
Asp Phe Leu Leu Phe Leu Glu Asn Ser Asp Gln Ala Thr Ile Ala Leu 
            500                 505                 510         
Leu Asn Leu Tyr Lys Ala Ser Gln Met Met Phe Pro Gly Glu Arg Ile 
        515                 520                 525             
Leu Glu Glu Ala Lys Leu Phe Ser Gln Asn Tyr Leu Glu Asn Ile Lys 
    530                 535                 540                 
Met Gly Asn Gln Ser Gly Ala Leu Lys Asp Ile Glu Ala Glu Val Lys 
545                 550                 555                 560 
His Ala Leu Asp Val Pro Trp Met Ala Asn Leu Glu Arg Ile Glu His 
                565                 570                 575     
Leu Arg Tyr Met Lys Ala Phe Ala Phe Asp Asn Ile Trp Ile Gly Glu 
            580                 585                 590         
Thr Ser Ser Arg Ile Pro Phe Thr Gly Lys Asp Leu Phe Leu Ser Phe 
        595                 600                 605             
Ala Lys Gln Asp Phe Asn Ile Cys Gln Ala Ala Gln Gln Glu Asp Leu 
    610                 615                 620                 
Lys Ala Leu Glu Lys Trp Ser Val Asp Ser Lys Leu Gly Asp Leu His 
625                 630                 635                 640 
Phe Ala Arg Gln Lys Leu Val Ala Cys Tyr Phe Ser Ala Ala Ser Ile 
                645                 650                 655     
Leu Phe Ser Pro Glu Met Ser Ala Thr Arg Ile Val Trp Thr Lys Asn 
            660                 665                 670         
Ala Val Leu Ile Thr Leu Met Asp Asp Phe Tyr Asp Val Glu Gly Ser 
        675                 680                 685             
Ile Glu Asp Ile Gln Ser Phe Val Glu Ala Val Lys Arg Trp Asp Pro 
    690                 695                 700                 
Ile Val Leu Cys Asn Cys Ser Ala Asn Val Lys Ile Leu Phe Ser Ala 
705                 710                 715                 720 
Ile Tyr Asn Thr Val Asn Asp Ile Ala Gln Asp Ile Trp Ile Phe Gln 
                725                 730                 735     
Gly Trp Asp Ile Ser Thr Gln Leu Arg Glu Ile Trp Tyr Glu Leu Ala 
            740                 745                 750         
Ile Ser Met Met Lys Glu Ala Glu Trp Thr Lys Thr Gly Phe Ile Pro 
        755                 760                 765             
Ser Leu Glu Glu Tyr Met Glu Asn Gly Arg Thr Ser Ile Ala Leu Glu 
    770                 775                 780                 
Pro Ile Ile Phe Thr Ser Leu Phe Phe Ile Gly Pro Lys Leu Ser Glu 
785                 790                 795                 800 
Gln Met Ile His His His Glu Tyr Lys Arg Leu Leu Gln Leu Met Asn 
                805                 810                 815     
Thr Cys Gly Arg Leu Leu Asn Asp Ile Gln Ser Asp Lys Arg Glu Met 
            820                 825                 830         
Lys Gln Gly Lys Leu Thr Ser Val Ser Leu Phe Val Lys Glu Tyr Pro 
        835                 840                 845             
Ile Glu Asp Ala Thr Lys Trp Ile Arg Leu Thr Val Ser Glu Asn Thr 
    850                 855                 860                 
Gln Asn Ile Leu Lys Lys Ile Leu Gln Pro Ser Glu Ile Pro Arg Glu 
865                 870                 875                 880 
Cys Lys Gln Ile Phe Trp Asn Met Val Lys Ile Ile Gln Leu Phe Cys 
                885                 890                 895     
Leu His Ser Asp Glu Phe Thr Ser Pro Thr Thr Met Leu Glu His Met 
            900                 905                 910         
Lys Ala Val Leu Phe Tyr Pro Val Leu 
        915                 920     

<210> 9
<211> 922
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 9
Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      
Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          
Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              
Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  
His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  
Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      
Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         
Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             
Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 
Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 
Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     
Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         
Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             
Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 
Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 
Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     
Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         
Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             
Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 
Leu Lys Ser Tyr Glu Glu Glu Leu Val Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 
Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     
Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         
Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Gly 
        355                 360                 365             
Gly Gly Ala Ala Met Glu Asn Lys Ser Phe Gly Ser Met Cys Ile Asp 
    370                 375                 380                 
Asp Asn Ile Thr Arg Ile Asn Met Leu Phe Leu Glu Ile Lys Arg Arg 
385                 390                 395                 400 
Tyr Ser Ser Leu Ser Ala Tyr Asp Thr Val His Gly Ala Tyr Pro Ile 
                405                 410                 415     
Asn Leu Ile Leu Gly Leu Ser Met Val Asn His Leu Glu Ser Leu Gly 
            420                 425                 430         
Ile Ala Arg His Phe Lys Leu Glu Ile Lys Glu Val Leu Asp Asp Val 
        435                 440                 445             
Tyr Arg Phe Trp Ile Glu Asn Glu Met Val Lys Gly Met Pro Ser Ala 
    450                 455                 460                 
Ser Asp Ile Met Thr Ser Ser Ile Ser Phe Lys Ile Leu Arg Trp Asn 
465                 470                 475                 480 
Gly Tyr Asp Val Ser Pro Asp Val Phe Phe Ser Tyr Leu Arg Asp Ser 
                485                 490                 495     
Asp Phe Leu Pro Phe Leu Glu Asn Ser Gly Gln Ala Thr Met Ala Leu 
            500                 505                 510         
Leu Asn Leu Tyr Lys Ala Ser Gln Met Met Phe Pro Gly Glu Arg Ile 
        515                 520                 525             
Leu Glu Glu Ala Lys Ser Phe Ser Gln Asn Tyr Leu Glu Asn Ile Lys 
    530                 535                 540                 
Val Gly Asp Gln Ser Gly Ala Leu Lys Asp Ile Glu Ala Glu Val Lys 
545                 550                 555                 560 
His Ala Leu Asp Val Pro Trp Met Ala Gly Leu Glu Arg Ile Glu His 
                565                 570                 575     
Leu Arg Tyr Met Lys Ala Phe Ala Phe Asp Asp Ile Trp Ile Gly Glu 
            580                 585                 590         
Thr Ser Ser Arg Ile Pro Phe Thr Gly Lys Asp Leu Phe Leu Ser Leu 
        595                 600                 605             
Ala Lys Gln Asp Phe Asn Ile Cys Gln Glu Ala Gln Gln Glu Asp Leu 
    610                 615                 620                 
Lys Ala Leu Glu Lys Trp Ser Val Asp Ser Lys Leu Gly Asp Leu His 
625                 630                 635                 640 
Phe Ala Arg Gln Lys Leu Val Ala Cys Tyr Phe Ser Ala Ala Ser Thr 
                645                 650                 655     
Leu Phe Ser Pro Glu Met Ser Thr Thr Arg Ile Val Trp Thr Lys Asn 
            660                 665                 670         
Ala Val Leu Thr Thr Leu Met Asp Asp Phe Tyr Asp Val Glu Gly Ser 
        675                 680                 685             
Ile Glu Asp Ile Gln Ser Phe Val Glu Ala Val Lys Arg Trp Asp Pro 
    690                 695                 700                 
Ile Val Leu Cys Asn Cys Ser Ala Asn Val Lys Lys Leu Phe Ser Ala 
705                 710                 715                 720 
Ile Tyr Asn Thr Val Asn Asp Ile Ala Gln Asp Ile Trp Ile Phe Gln 
                725                 730                 735     
Gly Trp Asp Ile Ser Thr Gln Leu Arg Glu Ile Trp Tyr Glu Leu Ala 
            740                 745                 750         
Ile Ser Met Met Lys Glu Ala Glu Trp Thr Lys Thr Gly Phe Ile Pro 
        755                 760                 765             
Ser Leu Glu Glu Tyr Met Glu Asn Gly Arg Thr Ser Ile Ala Leu Glu 
    770                 775                 780                 
Pro Ile Ile Phe Thr Ser Leu Phe Phe Leu Gly Pro Lys Leu Ser Glu 
785                 790                 795                 800 
Gln Met Ile His Glu Tyr Lys Arg Leu Met Gln Leu Leu Asn Thr Cys 
                805                 810                 815     
Gly Arg Leu Leu Asn Asp Ser Gln Ser Tyr Lys Arg Glu Ile Lys Gln 
            820                 825                 830         
Gly Lys Leu Thr Ser Leu Ser Leu Phe Val Lys Glu Tyr Pro Ala His 
        835                 840                 845             
Leu Ile Glu Asp Ala Thr Glu Trp Ile Arg Leu Thr Val Ser Glu Ser 
    850                 855                 860                 
Arg Gln Asn Ile Leu Arg Asn Leu Leu Gln Pro Ser Glu Ile Pro Arg 
865                 870                 875                 880 
Glu Cys Lys Gln Ile Phe Trp Asn Met Val Lys Ile Ile Gln Leu Phe 
                885                 890                 895     
Tyr Leu His Ser Asp Glu Phe Thr Ser Pro Thr Ala Met Leu Glu His 
            900                 905                 910         
Met Gln Ala Val Leu Phe Asn Pro Val Leu 
        915                 920         

<210> 10
<211> 922
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 10
Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      
Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          
Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              
Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  
His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  
Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      
Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         
Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             
Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 
Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 
Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     
Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         
Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             
Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 
Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 
Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     
Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         
Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             
Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 
Leu Lys Ser Tyr Glu Glu Glu Leu Val Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 
Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     
Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         
Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Gly 
        355                 360                 365             
Gly Gly Ala Ala Met Glu Asn Lys Ser Phe Gly Ser Met Cys Ile Asp 
    370                 375                 380                 
Asp Asn Ile Thr Arg Ile Asn Met Leu Phe Leu Glu Ile Lys Arg Arg 
385                 390                 395                 400 
Tyr Ser Ser Leu Ser Ala Tyr Asp Thr Val His Gly Ala Tyr Pro Ile 
                405                 410                 415     
Asn Leu Ile Leu Gly Leu Ser Met Val Asn His Leu Glu Ser Leu Gly 
            420                 425                 430         
Ile Ala Arg His Phe Lys Leu Glu Ile Lys Glu Val Leu Asp Asp Val 
        435                 440                 445             
Tyr Arg Phe Trp Ile Glu Asn Glu Met Val Lys Gly Met Pro Ser Ala 
    450                 455                 460                 
Ser Asp Ile Met Thr Ser Ser Ile Ser Phe Lys Ile Leu Arg Trp Asn 
465                 470                 475                 480 
Gly Tyr Asp Val Ser Pro Asp Val Phe Phe Ser Tyr Leu Arg Asp Ser 
                485                 490                 495     
Asp Phe Leu Pro Phe Leu Glu Asn Ser Gly Gln Ala Thr Met Ala Leu 
            500                 505                 510         
Leu Asn Leu Tyr Lys Ala Ser Gln Met Met Phe Pro Gly Glu Arg Ile 
        515                 520                 525             
Leu Glu Glu Ala Lys Ser Phe Ser Gln Asn Tyr Leu Glu Asn Ile Lys 
    530                 535                 540                 
Val Gly Asp Gln Ser Gly Ala Leu Lys Asp Ile Glu Ala Glu Val Lys 
545                 550                 555                 560 
His Ala Leu Asp Val Pro Trp Met Ala Gly Leu Glu Arg Ile Glu His 
                565                 570                 575     
Leu Arg Tyr Met Lys Ala Phe Ala Phe Asp Asp Ile Trp Ile Gly Glu 
            580                 585                 590         
Thr Ser Ser Arg Ile Pro Phe Thr Gly Lys Asp Leu Phe Leu Ser Leu 
        595                 600                 605             
Ala Lys Gln Asp Phe Asn Ile Cys Gln Glu Ala Gln Gln Glu Asp Leu 
    610                 615                 620                 
Lys Ala Leu Glu Lys Trp Ser Val Asp Ser Lys Leu Gly Asp Leu His 
625                 630                 635                 640 
Phe Ala Arg Gln Lys Leu Val Ala Cys Tyr Phe Ser Ala Ala Ser Thr 
                645                 650                 655     
Leu Phe Ser Pro Glu Met Ser Thr Thr Arg Ile Val Trp Thr Lys Asn 
            660                 665                 670         
Ala Val Leu Thr Thr Leu Met Asp Asp Phe Tyr Asp Val Glu Gly Ser 
        675                 680                 685             
Ile Glu Asp Ile Gln Ser Phe Val Glu Ala Val Lys Arg Trp Asp Pro 
    690                 695                 700                 
Ile Val Leu Cys Asn Cys Ser Ala Asn Val Lys Lys Leu Phe Ser Ala 
705                 710                 715                 720 
Ile Tyr Asn Thr Val Asn Asp Ile Ala Gln Asp Ile Trp Ile Phe Gln 
                725                 730                 735     
Gly Trp Asp Ile Ser Thr Gln Leu Arg Glu Ile Trp Tyr Glu Leu Ala 
            740                 745                 750         
Ile Ser Met Met Lys Glu Ala Glu Trp Thr Lys Thr Gly Phe Ile Pro 
        755                 760                 765             
Ser Leu Glu Glu Tyr Met Glu Asn Gly Arg Thr Ser Ile Ala Leu Glu 
    770                 775                 780                 
Pro Ile Ile Phe Thr Ser Leu Phe Phe Leu Gly Pro Lys Leu Ser Glu 
785                 790                 795                 800 
Gln Met Ile His Glu Tyr Lys Arg Leu Met Gln Leu Leu Asn Thr Cys 
                805                 810                 815     
Gly Arg Leu Leu Asn Asp Ser Gln Ser Tyr Lys Arg Glu Ile Lys Gln 
            820                 825                 830         
Gly Lys Leu Asn Ser Leu Ser Leu Phe Val Lys Glu Tyr Pro Ala Thr 
        835                 840                 845             
Ser Ile Glu Asp Ala Thr Glu Trp Ile Arg Leu Thr Val Ser Glu Ser 
    850                 855                 860                 
Arg Gln Asn Ile Leu Arg Asn Leu Leu Gln Pro Ser Glu Ile Pro Arg 
865                 870                 875                 880 
Glu Cys Lys Gln Ile Phe Trp Asn Met Val Lys Ile Ile Gln Leu Phe 
                885                 890                 895     
Tyr Leu His Ser Asp Glu Phe Thr Ser Pro Thr Ala Met Leu Glu His 
            900                 905                 910         
Met Gln Ala Val Leu Phe Asn Pro Val Leu 
        915                 920         

<210> 11
<211> 525
<212> PRT
<213> Artificial Sequence


<220> 
<223> truncated protein

<400> 11
Met Ala Lys Met Lys Glu Asn Phe Lys Arg Glu Asp Asp Lys Phe Pro 
1               5                   10                  15      
Thr Thr Thr Thr Leu Arg Ser Glu Asp Ile Pro Ser Asn Leu Cys Ile 
            20                  25                  30          
Ile Asp Thr Leu Gln Arg Leu Gly Val Asp Gln Phe Phe Gln Tyr Glu 
        35                  40                  45              
Ile Asn Thr Ile Leu Asp Asn Thr Phe Arg Leu Trp Gln Glu Lys His 
    50                  55                  60                  
Lys Val Ile Tyr Gly Asn Val Thr Thr His Ala Met Ala Phe Arg Leu 
65                  70                  75                  80  
Leu Arg Val Lys Gly Tyr Glu Val Ser Ser Glu Glu Leu Ala Pro Tyr 
                85                  90                  95      
Gly Asn Gln Glu Ala Val Ser Gln Gln Thr Asn Asp Leu Pro Met Ile 
            100                 105                 110         
Ile Glu Leu Tyr Arg Ala Ala Asn Glu Arg Ile Tyr Glu Glu Glu Arg 
        115                 120                 125             
Ser Leu Glu Lys Ile Leu Ala Trp Thr Thr Ile Phe Leu Asn Lys Gln 
    130                 135                 140                 
Val Gln Asp Asn Ser Ile Pro Asp Lys Lys Leu His Lys Leu Val Glu 
145                 150                 155                 160 
Phe Tyr Leu Arg Asn Tyr Lys Gly Ile Thr Ile Arg Leu Gly Ala Arg 
                165                 170                 175     
Arg Asn Leu Glu Leu Tyr Asp Met Thr Tyr Tyr Gln Ala Leu Lys Ser 
            180                 185                 190         
Thr Asn Arg Phe Ser Asn Leu Cys Asn Glu Asp Phe Leu Val Phe Ala 
        195                 200                 205             
Lys Gln Asp Phe Asp Ile His Glu Ala Gln Asn Gln Lys Gly Leu Gln 
    210                 215                 220                 
Gln Leu Gln Arg Trp Tyr Ala Asp Cys Arg Leu Asp Thr Leu Asn Phe 
225                 230                 235                 240 
Gly Arg Asp Val Val Ile Ile Ala Asn Tyr Leu Ala Ser Leu Ile Ile 
                245                 250                 255     
Gly Asp His Ala Phe Asp Tyr Val Arg Leu Ala Phe Ala Lys Thr Ser 
            260                 265                 270         
Val Leu Val Thr Ile Met Asp Asp Phe Phe Asp Cys His Gly Ser Ser 
        275                 280                 285             
Gln Glu Cys Asp Lys Ile Ile Glu Leu Val Lys Glu Trp Lys Glu Asn 
    290                 295                 300                 
Pro Asp Ala Glu Tyr Gly Ser Glu Glu Leu Glu Ile Leu Phe Met Ala 
305                 310                 315                 320 
Leu Tyr Asn Thr Val Asn Glu Leu Ala Glu Arg Ala Arg Val Glu Gln 
                325                 330                 335     
Gly Arg Ser Val Lys Glu Phe Leu Val Lys Leu Trp Val Glu Ile Leu 
            340                 345                 350         
Ser Ala Phe Lys Ile Glu Leu Asp Thr Trp Ser Asn Gly Thr Gln Gln 
        355                 360                 365             
Ser Phe Asp Glu Tyr Ile Ser Ser Ser Trp Leu Ser Asn Gly Ser Arg 
    370                 375                 380                 
Leu Thr Gly Leu Leu Thr Met Gln Phe Val Gly Val Lys Leu Ser Asp 
385                 390                 395                 400 
Glu Met Leu Met Ser Glu Glu Cys Thr Asp Leu Ala Arg His Val Cys 
                405                 410                 415     
Met Val Gly Arg Leu Leu Asn Asp Val Cys Ser Ser Glu Arg Glu Arg 
            420                 425                 430         
Glu Glu Asn Ile Ala Gly Lys Ser Tyr Ser Ile Leu Leu Ala Thr Glu 
        435                 440                 445             
Lys Asp Gly Arg Lys Val Ser Glu Asp Glu Ala Ile Ala Glu Ile Asn 
    450                 455                 460                 
Glu Met Val Glu Tyr His Trp Arg Lys Val Leu Gln Ile Val Tyr Lys 
465                 470                 475                 480 
Lys Glu Ser Ile Leu Pro Arg Arg Cys Lys Asp Val Phe Leu Glu Met 
                485                 490                 495     
Ala Lys Gly Thr Phe Tyr Ala Tyr Gly Ile Asn Asp Glu Leu Thr Ser 
            500                 505                 510         
Pro Gln Gln Ser Lys Glu Asp Met Lys Ser Phe Val Phe 
        515                 520                 525 

<210> 12
<211> 864
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 12
Met Ser Asp Lys Ile Ile His Leu Thr Asp Asp Ser Phe Asp Thr Asp 
1               5                   10                  15      
Val Leu Lys Ala Asp Gly Ala Ile Leu Val Asp Phe Trp Ala Glu Trp 
            20                  25                  30          
Cys Gly Pro Cys Lys Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp 
        35                  40                  45              
Glu Tyr Gln Gly Lys Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn 
    50                  55                  60                  
Pro Gly Thr Ala Pro Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu 
65                  70                  75                  80  
Leu Phe Lys Asn Gly Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser 
                85                  90                  95      
Lys Gly Gln Leu Lys Glu Phe Leu Asp Ala Asn Leu Ala Gly Gly Asp 
            100                 105                 110         
Asp Asp Asp Lys Ile His Met Asn Asn Gly Lys Asn Leu Asn Cys Gln 
        115                 120                 125             
Leu Thr His Lys Lys Ile Ser Lys Val Ala Glu Ile Arg Val Ala Thr 
    130                 135                 140                 
Val Asn Ala Pro Pro Val His Asp Gln Asp Asp Ser Thr Glu Asn Gln 
145                 150                 155                 160 
Cys His Asp Ala Val Asn Asn Ile Glu Asp Pro Ile Glu Tyr Ile Arg 
                165                 170                 175     
Thr Leu Leu Arg Thr Thr Gly Asp Gly Arg Ile Ser Val Ser Pro Tyr 
            180                 185                 190         
Asp Thr Ala Trp Val Ala Leu Ile Lys Asp Leu Gln Gly Arg Asp Ala 
        195                 200                 205             
Pro Glu Phe Pro Ser Ser Leu Glu Trp Ile Ile Gln Asn Gln Leu Ala 
    210                 215                 220                 
Asp Gly Ser Trp Gly Asp Ala Lys Phe Phe Cys Val Tyr Asp Arg Leu 
225                 230                 235                 240 
Val Asn Thr Ile Ala Cys Val Val Ala Leu Arg Ser Trp Asp Val His 
                245                 250                 255     
Ala Glu Lys Val Glu Arg Gly Val Arg Tyr Ile Asn Glu Asn Val Glu 
            260                 265                 270         
Lys Leu Arg Asp Gly Asn Glu Glu His Met Thr Cys Gly Phe Glu Val 
        275                 280                 285             
Val Phe Pro Ala Leu Leu Gln Arg Ala Lys Ser Leu Gly Ile Gln Asp 
    290                 295                 300                 
Leu Pro Tyr Asp Ala Pro Val Ile Gln Glu Ile Tyr His Ser Arg Glu 
305                 310                 315                 320 
Gln Lys Ser Lys Arg Ile Pro Leu Glu Met Met His Lys Val Pro Thr 
                325                 330                 335     
Ser Leu Leu Phe Ser Leu Glu Gly Leu Glu Asn Leu Glu Trp Asp Lys 
            340                 345                 350         
Leu Leu Lys Leu Gln Ser Ala Asp Gly Ser Phe Leu Thr Ser Pro Ser 
        355                 360                 365             
Ser Thr Ala Phe Ala Phe Met Gln Thr Arg Asp Pro Lys Cys Tyr Gln 
    370                 375                 380                 
Phe Ile Lys Asn Thr Ile Gln Thr Phe Asn Gly Gly Ala Pro His Thr 
385                 390                 395                 400 
Tyr Pro Val Asp Val Phe Gly Arg Leu Trp Ala Ile Asp Arg Leu Gln 
                405                 410                 415     
Arg Leu Gly Ile Ser Arg Phe Phe Glu Ser Glu Ile Ala Asp Cys Ile 
            420                 425                 430         
Ala His Ile His Arg Phe Trp Thr Glu Lys Gly Val Phe Ser Gly Arg 
        435                 440                 445             
Glu Ser Glu Phe Cys Asp Ile Asp Asp Thr Ser Met Gly Val Arg Leu 
    450                 455                 460                 
Met Arg Met His Gly Tyr Asp Val Asp Pro Asn Val Leu Lys Asn Phe 
465                 470                 475                 480 
Lys Lys Asp Asp Lys Phe Ser Cys Tyr Gly Gly Gln Met Ile Glu Ser 
                485                 490                 495     
Pro Ser Pro Ile Tyr Asn Leu Tyr Arg Ala Ser Gln Leu Arg Phe Pro 
            500                 505                 510         
Gly Glu Gln Ile Leu Glu Asp Ala Asn Lys Phe Ala Tyr Asp Phe Leu 
        515                 520                 525             
Gln Glu Lys Leu Ala His Asn Gln Ile Leu Asp Lys Trp Val Ile Ser 
    530                 535                 540                 
Lys His Leu Pro Asp Glu Ile Lys Leu Gly Leu Glu Met Pro Trp Tyr 
545                 550                 555                 560 
Ala Thr Leu Pro Arg Val Glu Ala Arg Tyr Tyr Ile Gln Tyr Tyr Ala 
                565                 570                 575     
Gly Ser Gly Asp Val Trp Ile Gly Lys Thr Leu Tyr Arg Met Pro Glu 
            580                 585                 590         
Ile Ser Asn Asp Thr Tyr His Glu Leu Ala Lys Thr Asp Phe Lys Arg 
        595                 600                 605             
Cys Gln Ala Gln His Gln Phe Glu Trp Ile Tyr Met Gln Glu Trp Tyr 
    610                 615                 620                 
Glu Ser Cys Asn Met Glu Glu Phe Gly Ile Ser Arg Lys Glu Leu Leu 
625                 630                 635                 640 
Val Ala Tyr Phe Leu Ala Thr Ala Ser Ile Phe Glu Leu Glu Arg Ala 
                645                 650                 655     
Asn Glu Arg Ile Ala Trp Ala Lys Ser Gln Ile Ile Ser Thr Ile Ile 
            660                 665                 670         
Ala Ser Phe Phe Asn Asn Gln Asn Thr Ser Pro Glu Asp Lys Leu Ala 
        675                 680                 685             
Phe Leu Thr Asp Phe Lys Asn Gly Asn Ser Thr Asn Met Ala Leu Val 
    690                 695                 700                 
Thr Leu Thr Gln Phe Leu Glu Gly Phe Asp Arg Tyr Thr Ser His Gln 
705                 710                 715                 720 
Leu Lys Asn Ala Trp Ser Val Trp Leu Arg Lys Leu Gln Gln Gly Glu 
                725                 730                 735     
Gly Asn Gly Gly Ala Asp Ala Glu Leu Leu Val Asn Thr Leu Asn Ile 
            740                 745                 750         
Cys Ala Gly His Ile Ala Phe Arg Glu Glu Ile Leu Ala His Asn Asp 
        755                 760                 765             
Tyr Lys Thr Leu Ser Asn Leu Thr Ser Lys Ile Cys Arg Gln Leu Ser 
    770                 775                 780                 
Gln Ile Gln Asn Glu Lys Glu Leu Glu Thr Glu Gly Gln Lys Thr Ser 
785                 790                 795                 800 
Ile Lys Asn Lys Glu Leu Glu Glu Asp Met Gln Arg Leu Val Lys Leu 
                805                 810                 815     
Val Leu Glu Lys Ser Arg Val Gly Ile Asn Arg Asp Met Lys Lys Thr 
            820                 825                 830         
Phe Leu Ala Val Val Lys Thr Tyr Tyr Tyr Lys Ala Tyr His Ser Ala 
        835                 840                 845             
Gln Ala Ile Asp Asn His Met Phe Lys Val Leu Phe Glu Pro Val Ala 
    850                 855                 860                 



<210> 13
<211> 849
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 13
Met Ser Asp Lys Ile Ile His Leu Thr Asp Asp Ser Phe Asp Thr Asp 
1               5                   10                  15      
Val Leu Lys Ala Asp Gly Ala Ile Leu Val Asp Phe Trp Ala Glu Trp 
            20                  25                  30          
Cys Gly Pro Cys Lys Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp 
        35                  40                  45              
Glu Tyr Gln Gly Lys Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn 
    50                  55                  60                  
Pro Gly Thr Ala Pro Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu 
65                  70                  75                  80  
Leu Phe Lys Asn Gly Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser 
                85                  90                  95      
Lys Gly Gln Leu Lys Glu Phe Leu Asp Ala Asn Leu Ala Gly Gly Asp 
            100                 105                 110         
Asp Asp Asp Lys Ile His Met Cys Arg Val Ala Ser Leu Asp Ala Leu 
        115                 120                 125             
Asn Gly Ile Gln Lys Val Gly Pro Ala Thr Ile Gly Thr Pro Glu Glu 
    130                 135                 140                 
Glu Asn Lys Lys Ile Glu Asp Ser Ile Glu Tyr Val Lys Glu Leu Leu 
145                 150                 155                 160 
Lys Thr Met Gly Asp Gly Arg Ile Ser Val Ser Pro Tyr Asp Thr Ala 
                165                 170                 175     
Ile Val Ala Leu Ile Lys Asp Leu Glu Gly Gly Asp Gly Pro Glu Phe 
            180                 185                 190         
Pro Ser Cys Leu Glu Trp Ile Ala Gln Asn Gln Leu Ala Asp Gly Ser 
        195                 200                 205             
Trp Gly Asp His Phe Phe Cys Ile Tyr Asp Arg Val Val Asn Thr Ala 
    210                 215                 220                 
Ala Cys Val Val Ala Leu Lys Ser Trp Asn Val His Ala Asp Lys Ile 
225                 230                 235                 240 
Glu Lys Gly Ala Val Tyr Leu Lys Glu Asn Val His Lys Leu Lys Asp 
                245                 250                 255     
Gly Lys Ile Glu His Met Pro Ala Gly Phe Glu Phe Val Val Pro Ala 
            260                 265                 270         
Thr Leu Glu Arg Ala Lys Ala Leu Gly Ile Lys Gly Leu Pro Tyr Asp 
        275                 280                 285             
Asp Pro Phe Ile Arg Glu Ile Tyr Ser Ala Lys Gln Thr Arg Leu Thr 
    290                 295                 300                 
Lys Ile Pro Lys Gly Met Ile Tyr Glu Ser Pro Thr Ser Leu Leu Tyr 
305                 310                 315                 320 
Ser Leu Asp Gly Leu Glu Gly Leu Glu Trp Asp Lys Ile Leu Lys Leu 
                325                 330                 335     
Gln Ser Ala Asp Gly Ser Phe Ile Thr Ser Val Ser Ser Thr Ala Phe 
            340                 345                 350         
Val Phe Met His Thr Asn Asp Leu Lys Cys His Ala Phe Ile Lys Asn 
        355                 360                 365             
Ala Leu Thr Asn Cys Asn Gly Gly Val Pro His Thr Tyr Pro Val Asp 
    370                 375                 380                 
Ile Phe Ala Arg Leu Trp Ala Val Asp Arg Leu Gln Arg Leu Gly Ile 
385                 390                 395                 400 
Ser Arg Phe Phe Glu Pro Glu Ile Lys Tyr Leu Met Asp His Ile Asn 
                405                 410                 415     
Asn Val Trp Arg Glu Lys Gly Val Phe Ser Ser Arg His Ser Gln Phe 
            420                 425                 430         
Ala Asp Ile Asp Asp Thr Ser Met Gly Ile Arg Leu Leu Lys Met His 
        435                 440                 445             
Gly Tyr Asn Val Asn Pro Asn Ala Leu Glu His Phe Lys Gln Lys Asp 
    450                 455                 460                 
Gly Lys Phe Thr Cys Tyr Ala Asp Gln His Ile Glu Ser Pro Ser Pro 
465                 470                 475                 480 
Met Tyr Asn Leu Tyr Arg Ala Ala Gln Leu Arg Phe Pro Gly Glu Glu 
                485                 490                 495     
Ile Leu Gln Gln Ala Leu Gln Phe Ala Tyr Asn Phe Leu His Glu Asn 
            500                 505                 510         
Leu Ala Ser Asn His Phe Gln Glu Lys Trp Val Ile Ser Asp His Leu 
        515                 520                 525             
Ile Asp Glu Val Arg Ile Gly Leu Lys Met Pro Trp Tyr Ala Thr Leu 
    530                 535                 540                 
Pro Arg Val Glu Ala Ser Tyr Tyr Leu Gln His Tyr Gly Gly Ser Ser 
545                 550                 555                 560 
Asp Val Trp Ile Gly Lys Thr Leu Tyr Arg Met Pro Glu Ile Ser Asn 
                565                 570                 575     
Asp Thr Tyr Lys Ile Leu Ala Gln Leu Asp Phe Asn Lys Cys Gln Ala 
            580                 585                 590         
Gln His Gln Leu Glu Trp Met Ser Met Lys Glu Trp Tyr Gln Ser Asn 
        595                 600                 605             
Asn Val Lys Glu Phe Gly Ile Ser Lys Lys Glu Leu Leu Leu Ala Tyr 
    610                 615                 620                 
Phe Leu Ala Ala Ala Thr Met Phe Glu Pro Glu Arg Thr Gln Glu Arg 
625                 630                 635                 640 
Ile Met Trp Ala Lys Thr Gln Val Val Ser Arg Met Ile Thr Ser Phe 
                645                 650                 655     
Leu Asn Lys Glu Asn Thr Met Ser Phe Asp Leu Lys Ile Ala Leu Leu 
            660                 665                 670         
Thr Gln Pro Gln His Gln Ile Asn Gly Ser Glu Met Lys Asn Gly Leu 
        675                 680                 685             
Ala Gln Thr Leu Pro Ala Ala Phe Arg Gln Leu Leu Lys Glu Phe Asp 
    690                 695                 700                 
Lys Tyr Thr Arg His Gln Leu Arg Asn Thr Trp Asn Lys Trp Leu Met 
705                 710                 715                 720 
Lys Leu Lys Gln Gly Asp Asp Asn Gly Gly Ala Asp Ala Glu Leu Leu 
                725                 730                 735     
Ala Asn Thr Leu Asn Ile Cys Ala Gly His Asn Glu Asp Ile Leu Ser 
            740                 745                 750         
His Tyr Glu Tyr Thr Ala Leu Ser Ser Leu Thr Asn Lys Ile Cys Gln 
        755                 760                 765             
Arg Leu Ser Gln Ile Gln Asp Lys Lys Met Leu Glu Ile Glu Glu Gly 
    770                 775                 780                 
Ser Ile Lys Asp Lys Glu Met Glu Leu Glu Ile Gln Thr Leu Val Lys 
785                 790                 795                 800 
Leu Val Leu Gln Glu Thr Ser Gly Gly Ile Asp Arg Asn Ile Lys Gln 
                805                 810                 815     
Thr Phe Leu Ser Val Phe Lys Thr Phe Tyr Tyr Arg Ala Tyr His Asp 
            820                 825                 830         
Ala Lys Thr Ile Asp Ala His Ile Phe Gln Val Leu Phe Glu Pro Val 
        835                 840                 845             
Val 
    

<210> 14
<211> 920
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 14
Met Ser Asp Lys Ile Ile His Leu Thr Asp Asp Ser Phe Asp Thr Asp 
1               5                   10                  15      
Val Leu Lys Ala Asp Gly Ala Ile Leu Val Asp Phe Trp Ala Glu Trp 
            20                  25                  30          
Cys Gly Pro Cys Lys Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp 
        35                  40                  45              
Glu Tyr Gln Gly Lys Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn 
    50                  55                  60                  
Pro Gly Thr Ala Pro Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu 
65                  70                  75                  80  
Leu Phe Lys Asn Gly Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser 
                85                  90                  95      
Lys Gly Gln Leu Lys Glu Phe Leu Asp Ala Asn Leu Ala Gly Gly Asp 
            100                 105                 110         
Asp Asp Asp Lys Ile His Met Gln Val Ile Ile Thr Ser Ser His Arg 
        115                 120                 125             
Phe Phe Cys His His Leu His Gln Leu Lys Ser Pro Thr Ser Leu Ser 
    130                 135                 140                 
Ala Gln Lys Ala Glu Phe Lys Lys His Gly Pro Arg Asn Trp Leu Phe 
145                 150                 155                 160 
Gln Thr Glu Gly Ser Leu Leu Tyr Lys Pro Val Arg Leu Asn Cys Ala 
                165                 170                 175     
Thr Ser Asp Ala Ser Tyr Leu Gly Asn Val Asn Glu Tyr Leu Glu Ser 
            180                 185                 190         
Asp His Ser Lys Asn Ser Glu Glu Lys Asp Ile Gln Val Ser Arg Thr 
        195                 200                 205             
Ile Gln Met Lys Gly Leu Thr Glu Glu Ile Lys His Met Leu Asn Ser 
    210                 215                 220                 
Met Glu Asp Gly Arg Leu Asn Val Leu Ala Tyr Asp Thr Ala Trp Val 
225                 230                 235                 240 
Ser Phe Ile Pro Asn Thr Thr Asn Asn Gly Asn Asp Gln Arg Pro Met 
                245                 250                 255     
Phe Pro Ser Cys Leu Gln Trp Ile Ile Asp Asn Gln Leu Ser Asp Gly 
            260                 265                 270         
Ser Trp Gly Glu Glu Ile Val Phe Cys Ile Tyr Asp Arg Leu Leu Asn 
        275                 280                 285             
Thr Leu Val Cys Val Ile Ala Leu Thr Leu Trp Asn Thr Cys Leu His 
    290                 295                 300                 
Lys Arg Asn Lys Gly Val Met Phe Ile Lys Glu Asn Leu Ser Lys Leu 
305                 310                 315                 320 
Glu Thr Gly Glu Val Glu Asn Met Thr Ser Gly Phe Glu Leu Val Phe 
                325                 330                 335     
Pro Thr Leu Leu Glu Lys Ala Gln Gln Leu Asp Ile Asp Ile Pro Tyr 
            340                 345                 350         
Asp Ala Pro Val Leu Lys Asp Ile Tyr Ala Arg Arg Glu Val Lys Leu 
        355                 360                 365             
Thr Arg Ile Pro Lys Asp Val Ile His Thr Ile Pro Thr Thr Val Leu 
    370                 375                 380                 
Phe Ser Leu Glu Gly Leu Arg Asp Asp Leu Asp Trp Gln Arg Leu Leu 
385                 390                 395                 400 
Lys Leu Gln Met Pro Asp Gly Ser Phe Leu Ile Ser Pro Ala Ser Thr 
                405                 410                 415     
Ala Phe Ala Phe Met Glu Thr Asn Asp Glu Lys Cys Leu Ala Tyr Leu 
            420                 425                 430         
Gln Asn Val Val Glu Lys Ser Asn Gly Gly Ala Arg Gln Tyr Pro Phe 
        435                 440                 445             
Asp Leu Val Thr Arg Leu Trp Ala Ile Asp Arg Leu Gln Arg Leu Gly 
    450                 455                 460                 
Ile Ser Tyr Tyr Phe Ala Glu Glu Phe Lys Glu Leu Leu Asn His Val 
465                 470                 475                 480 
Phe Arg Tyr Trp Asp Glu Glu Asn Gly Ile Phe Ser Gly Arg Asn Ser 
                485                 490                 495     
Asn Val Ser Asp Val Asp Asp Thr Cys Met Ala Ile Arg Leu Leu Arg 
            500                 505                 510         
Leu His Gly Tyr Asp Val Ser Pro Asp Ala Leu Asn Asn Phe Lys Asp 
        515                 520                 525             
Gly Asp Gln Phe Val Cys Phe Arg Gly Glu Val Asp Gly Ser Pro Thr 
    530                 535                 540                 
His Met Phe Asn Leu Tyr Arg Cys Ser Gln Val Leu Phe Pro Gly Glu 
545                 550                 555                 560 
Lys Ile Leu Glu Glu Ala Lys Asn Phe Thr Tyr Asn Phe Leu Gln Gln 
                565                 570                 575     
Cys Leu Ala Asn Asn Arg Cys Leu Asp Lys Trp Val Ile Ala Lys Asp 
            580                 585                 590         
Ile Pro Gly Glu Ile Trp Tyr Ala Leu Glu Phe Pro Trp Tyr Ala Ser 
        595                 600                 605             
Leu Pro Arg Val Glu Ala Arg Tyr Tyr Ile Glu Gln Tyr Gly Gly Ala 
    610                 615                 620                 
Asp Asp Ile Trp Ile Gly Lys Thr Leu Tyr Arg Met Pro Asp Val Asn 
625                 630                 635                 640 
Asn Asn Val Tyr Leu Gln Ala Ala Lys Leu Asp Tyr Asn Arg Cys Gln 
                645                 650                 655     
Ser Gln His Arg Phe Glu Trp Leu Ile Met Gln Glu Trp Phe Glu Lys 
            660                 665                 670         
Cys Asn Phe Gln Gln Phe Gly Ile Ser Lys Lys Tyr Leu Leu Val Ser 
        675                 680                 685             
Tyr Phe Leu Ala Ala Ala Ser Ile Phe Glu Val Glu Lys Ser Arg Glu 
    690                 695                 700                 
Arg Leu Ala Trp Ala Lys Ser Arg Ile Ile Cys Lys Met Ile Thr Ser 
705                 710                 715                 720 
Tyr Tyr Asn Asp Glu Ala Thr Thr Trp Thr Thr Arg Asn Ser Leu Leu 
                725                 730                 735     
Met Glu Phe Lys Val Ser His Asp Pro Thr Arg Lys Asn Gly Asn Glu 
            740                 745                 750         
Thr Lys Glu Ile Leu Val Leu Lys Asn Leu Arg Gln Phe Leu Arg Gln 
        755                 760                 765             
Leu Ser Glu Glu Thr Phe Glu Asp Leu Gly Lys Asp Ile His His Gln 
    770                 775                 780                 
Leu Gln Asn Ala Trp Glu Thr Trp Leu Val Phe Leu Arg Glu Glu Lys 
785                 790                 795                 800 
Asn Ala Cys Gln Glu Glu Thr Glu Leu Leu Val Arg Thr Ile Asn Leu 
                805                 810                 815     
Ser Gly Gly Tyr Met Thr His Asp Glu Ile Leu Phe Asp Ala Asp Tyr 
            820                 825                 830         
Glu Asn Leu Ser Asn Leu Thr Asn Lys Val Cys Gly Lys Leu Asn Glu 
        835                 840                 845             
Leu Gln Asn Asp Lys Val Thr Gly Gly Ser Lys Asn Thr Asn Ile Glu 
    850                 855                 860                 
Leu Asp Met Gln Ala Leu Val Lys Leu Val Phe Gly Asn Thr Ser Ser 
865                 870                 875                 880 
Asn Ile Asn Gln Asp Ile Lys Gln Thr Phe Phe Ala Val Val Lys Thr 
                885                 890                 895     
Phe Tyr Tyr Ser Ala His Val Ser Glu Glu Ile Met Asn Phe His Ile 
            900                 905                 910         
Ser Lys Val Leu Phe Gln Gln Val 
        915                 920 

<210> 15
<211> 366
<212> PRT
<213> Cupressus gigantea


<400> 15
Met Ser Ser Phe Asp Ala His Asp Leu Asp Leu Asp Lys Phe Pro Glu 
1               5                   10                  15      
Val Val Arg Asp Arg Leu Thr Gln Phe Leu Asp Ala Gln Glu Leu Thr 
            20                  25                  30          
Ile Ala Asp Ile Gly Ala Pro Val Thr Asp Ala Val Ala His Leu Arg 
        35                  40                  45              
Ser Phe Val Leu Asn Gly Gly Lys Arg Ile Arg Pro Leu Tyr Ala Trp 
    50                  55                  60                  
Ala Gly Phe Leu Ala Ala Gln Gly His Lys Asn Ser Ser Glu Lys Leu 
65                  70                  75                  80  
Glu Ser Val Leu Asp Ala Ala Ala Ser Leu Glu Phe Ile Gln Ala Cys 
                85                  90                  95      
Ala Leu Ile His Asp Asp Ile Ile Asp Ser Ser Asp Thr Arg Arg Gly 
            100                 105                 110         
Ala Pro Thr Val His Arg Ala Val Glu Ala Asp His Arg Ala Asn Asn 
        115                 120                 125             
Phe Glu Gly Asp Pro Glu His Phe Gly Val Ser Val Ser Ile Leu Ala 
    130                 135                 140                 
Gly Asp Met Ala Leu Val Trp Ala Glu Asp Met Leu Gln Asp Ser Gly 
145                 150                 155                 160 
Leu Ser Ala Glu Ala Leu Ala Arg Thr Arg Asp Ala Trp Arg Gly Met 
                165                 170                 175     
Arg Thr Glu Val Ile Gly Gly Gln Leu Leu Asp Ile Tyr Leu Glu Ser 
            180                 185                 190         
His Ala Asn Glu Ser Val Glu Leu Ala Asp Ser Val Asn Arg Phe Lys 
        195                 200                 205             
Thr Ala Ala Tyr Thr Ile Ala Arg Pro Leu His Leu Gly Ala Ser Ile 
    210                 215                 220                 
Ala Gly Gly Ser Pro Gln Leu Ile Asp Ala Leu Leu His Tyr Gly His 
225                 230                 235                 240 
Asp Ile Gly Ile Ala Phe Gln Leu Arg Asp Asp Leu Leu Gly Val Phe 
                245                 250                 255     
Gly Asp Pro Ala Ile Thr Gly Lys Pro Ala Gly Asp Asp Ile Arg Glu 
            260                 265                 270         
Gly Lys Arg Thr Val Leu Leu Ala Leu Ala Leu Gln Arg Ala Asp Lys 
        275                 280                 285             
Gln Ser Pro Glu Ala Ala Thr Ala Ile Arg Ala Gly Val Gly Lys Val 
    290                 295                 300                 
Thr Ser Pro Glu Asp Ile Ala Val Ile Thr Glu His Ile Arg Ala Thr 
305                 310                 315                 320 
Gly Ala Glu Glu Glu Val Glu Gln Arg Ile Ser Gln Leu Thr Glu Ser 
                325                 330                 335     
Gly Leu Ala His Leu Asp Asp Val Asp Ile Pro Asp Glu Val Arg Ala 
            340                 345                 350         
Gln Leu Arg Ala Leu Ala Ile Arg Ser Thr Glu Arg Arg Met 
        355                 360                 365     

<210> 16
<211> 2769
<212> DNA
<213> Artificial Sequence


<220> 
<223> fusion

<400> 16
atgaagatcg aggaaggcaa gctcgtgatc tggatcaacg gcgacaaggg ctacaacggc      60

ctggccgagg tgggcaagaa gttcgagaag gacaccggca tcaaggtgac ggtggagcac     120

ccggacaagc tcgaggagaa gttcccgcag gtggcggcca cgggcgacgg cccggacatc     180

atcttctggg cccatgaccg cttcggcggc tacgcccagt cgggcctgct ggccgagatc     240

accccggaca aggcgttcca ggacaagctc tatcccttca cgtgggacgc cgtgcgctac     300

aacggcaagc tgatcgcgta tcccatcgcg gtggaggccc tgtcgctcat ctataacaag     360

gacctgctcc cgaacccgcc caagacctgg gaggagatcc ccgccctcga caaggagctg     420

aaggccaagg gcaagtcggc gctcatgttc aacctgcagg agccgtactt cacctggccc     480

ctgatcgcgg ccgacggcgg ctacgcgttc aagtatgaga acggcaagta tgacatcaag     540

gacgtgggcg tggacaacgc gggcgccaag gccggcctga ccttcctcgt ggacctgatc     600

aagaacaagc acatgaacgc cgacacggac tactcgatcg cggaggccgc gttcaacaag     660

ggcgagactg ccatgacgat caacggcccg tgggcgtggt cgaacatcga cacctcgaag     720

gtgaactatg gcgtgaccgt gctccccacg ttcaagggcc agccctcgaa gcccttcgtg     780

ggcgtgctgt cggcgggcat caacgccgcg tcgccgaaca aggagctcgc gaaggagttc     840

ctggagaact acctgctcac cgacgagggc ctggaggccg tgaacaagga caagcccctg     900

ggcgccgtgg ccctgaagtc gtatgaggaa gagctggtga aggacccgcg catcgcggcc     960

accatggaga acgcgcagaa gggcgagatc atgccgaaca tcccccagat gtcggccttc    1020

tggtatgcgg tgcgcaccgc cgtgatcaac gcggcctcgg gccgccagac cgtggacgag    1080

gccctcaagg acgcccagac cggcggaggt gctgccatgg agaacaagtc gttcggctcg    1140

atgtgcatcg acgacaacat cacccgcatc aacatgctct tcctcgagat caagcgccgc    1200

tactcgtcgc tctcggccta cgacaccgtg cacggcgcct acccgatcaa cctcatcctc    1260

ggcctctcga tggtgaacca cctcgagtcg ctcggcatcg cccgccactt caagctcgag    1320

atcaaggagg tgctcgacga cgtgtaccgc ttctggatcg agaacgagat ggtgaagggc    1380

atgccgtcgg cctcggacat catgacctcg tcgatctcgt tcaagatcct ccgctggaac    1440

ggctacgacg tgtcgccgga cgtgttcttc tcgtacctcc gcgactcgga cttcctcccg    1500

ttcctcgaga actcgggcca ggccactatg gccctcctca acctctacaa ggcctcgcag    1560

atgatgttcc cgggcgagcg catcctcgag gaggccaagt cgttctcgca gaactacctc    1620

gagaacatca aggtgggcga ccagtcgggc gccctcaagg acatcgaggc cgaggtgaag    1680

cacgccctcg acgtgccgtg gatggccggc ctcgagcgca tcgagcacct ccgctacatg    1740

aaggccttcg ccttcgacga catctggatc ggcgagacgt cgtcgcgcat cccgttcacc    1800

ggcaaggacc tcttcctctc gctcgccaag caggacttca acatctgcca ggaggcccag    1860

caggaggacc tcaaggccct cgagaagtgg tcggtggact cgaagctcgg cgacctccac    1920

ttcgcccgcc agaagctcgt ggcctgctac ttctcggccg cctcgaccct cttctcgccg    1980

gagatgtcga ccacccgcat cgtgtggacc aagaacgccg tgctcaccac cctcatggac    2040

gacttctacg acgtggaggg ctcgatcgag gacatccagt cgttcgtgga ggccgtgaag    2100

cgctgggacc cgatcgtgct ctgcaactgc tcggccaacg tgaagaagct cttctcggcc    2160

atctacaaca ccgtgaacga catcgcccag gacatctgga tcttccaggg ctgggacatc    2220

tcgacccagc tccgcgagat ctggtacgag ctcgccatct cgatgatgaa ggaggccgag    2280

tggaccaaga ccggcttcat cccgtcgctc gaggagtaca tggagaacgg ccgcacctcg    2340

atcgccctcg agccgatcat cttcacctcg ctcttcttcc tcggcccgaa gctctcggag    2400

cagatgatcc acgagtacaa gcgcctcatg cagctcctca acacctgcgg caggctcctc    2460

aacgactcgc agtcgtacaa gcgcgagatc aagcagggca agctcaactc gctctcgctc    2520

ttcgtgaagg agtacccggc cacctcgatc gaggacgcca ccgagtggat caggctcacc    2580

gtgtcggagt cgcgccagaa catcctccgc aacctcctcc agccgtcgga gatcccgcgc    2640

gagtgcaagc agatcttctg gaacatggtg aagatcatcc agctcttcta cctccactcg    2700

gacgagttca cctcgccgac cgccatgctc gagcacatgc aggccgtgct cttcaacccg    2760

gtgctctaa                                                            2769


<210> 17
<211> 2769
<212> DNA
<213> Artificial Sequence


<220> 
<223> fusion

<400> 17
atgaagatcg aggaaggcaa gctcgtgatc tggatcaacg gcgacaaggg ctacaacggc      60

ctggccgagg tgggcaagaa gttcgagaag gacaccggca tcaaggtgac ggtggagcac     120

ccggacaagc tcgaggagaa gttcccgcag gtggcggcca cgggcgacgg cccggacatc     180

atcttctggg cccatgaccg cttcggcggc tacgcccagt cgggcctgct ggccgagatc     240

accccggaca aggcgttcca ggacaagctc tatcccttca cgtgggacgc cgtgcgctac     300

aacggcaagc tgatcgcgta tcccatcgcg gtggaggccc tgtcgctcat ctataacaag     360

gacctgctcc cgaacccgcc caagacctgg gaggagatcc ccgccctcga caaggagctg     420

aaggccaagg gcaagtcggc gctcatgttc aacctgcagg agccgtactt cacctggccc     480

ctgatcgcgg ccgacggcgg ctacgcgttc aagtatgaga acggcaagta tgacatcaag     540

gacgtgggcg tggacaacgc gggcgccaag gccggcctga ccttcctcgt ggacctgatc     600

aagaacaagc acatgaacgc cgacacggac tactcgatcg cggaggccgc gttcaacaag     660

ggcgagactg ccatgacgat caacggcccg tgggcgtggt cgaacatcga cacctcgaag     720

gtgaactatg gcgtgaccgt gctccccacg ttcaagggcc agccctcgaa gcccttcgtg     780

ggcgtgctgt cggcgggcat caacgccgcg tcgccgaaca aggagctcgc gaaggagttc     840

ctggagaact acctgctcac cgacgagggc ctggaggccg tgaacaagga caagcccctg     900

ggcgccgtgg ccctgaagtc gtatgaggaa gagctggtga aggacccgcg catcgcggcc     960

accatggaga acgcgcagaa gggcgagatc atgccgaaca tcccccagat gtcggccttc    1020

tggtatgcgg tgcgcaccgc cgtgatcaac gcggcctcgg gccgccagac cgtggacgag    1080

gccctcaagg acgcccagac cggcggaggt gctgccatgg agaacaagtc gttcggctcg    1140

atgtgcatcg acgacaacat cacccgcatc aacatgctct tcctcgagat caagcgccgc    1200

tactcgtcgc tctcggccta cgacaccgtg cacggcgcct acccgatcaa cctcatcctc    1260

ggcctctcga tggtgaacca cctcgagtcg ctcggcatcg cccgccactt caagctcgag    1320

atcaaggagg tgctcgacga cgtgtaccgc ttctggatcg agaacgagat ggtgaagggc    1380

atgccgtcgg cctcggacat catgacctcg tcgatctcgt tcaagatcct ccgctggaac    1440

ggctacgacg tgtcgccgga cgtgttcttc tcgtacctcc gcgactcgga cttcctcccg    1500

ttcctcgaga actcgggcca ggccactatg gccctcctca acctctacaa ggcctcgcag    1560

atgatgttcc cgggcgagcg catcctcgag gaggccaagt cgttctcgca gaactacctc    1620

gagaacatca aggtgggcga ccagtcgggc gccctcaagg acatcgaggc cgaggtgaag    1680

cacgccctcg acgtgccgtg gatggccggc ctcgagcgca tcgagcacct ccgctacatg    1740

aaggccttcg ccttcgacga catctggatc ggcgagacgt cgtcgcgcat cccgttcacc    1800

ggcaaggacc tcttcctctc gctcgccaag caggacttca acatctgcca ggaggcccag    1860

caggaggacc tcaaggccct cgagaagtgg tcggtggact cgaagctcgg cgacctccac    1920

ttcgcccgcc agaagctcgt ggcctgctac ttctcggccg cctcgaccct cttctcgccg    1980

gagatgtcga ccacccgcat cgtgtggacc aagaacgccg tgctcaccac cctcatggac    2040

gacttctacg acgtggaggg ctcgatcgag gacatccagt cgttcgtgga ggccgtgaag    2100

cgctgggacc cgatcgtgct ctgcaactgc tcggccaacg tgaagaagct cttctcggcc    2160

atctacaaca ccgtgaacga catcgcccag gacatctgga tcttccaggg ctgggacatc    2220

tcgacccagc tccgcgagat ctggtacgag ctcgccatct cgatgatgaa ggaggccgag    2280

tggaccaaga ccggcttcat cccgtcgctc gaggagtaca tggagaacgg ccgcacctcg    2340

atcgccctcg agccgatcat cttcacctcg ctcttcttcc tcggcccgaa gctctcggag    2400

cagatgatcc acgagtacaa gcgcctcatg cagctcctca acacctgcgg caggctcctc    2460

aacgactcgc agtcgtacaa gcgcgagatc aagcagggca agctcacctc gctctcgctc    2520

ttcgtgaagg agtacccggc ccacctcatc gaggacgcca ccgagtggat caggctcacc    2580

gtgtcggagt cgcgccagaa catcctccgc aacctcctcc agccgtcgga gatcccgcgc    2640

gagtgcaagc agatcttctg gaacatggtg aagatcatcc agctcttcta cctccactcg    2700

gacgagttca cctcgccgac cgccatgctc gagcacatgc aggccgtgct cttcaacccg    2760

gtgctctaa                                                            2769


<210> 18
<211> 2766
<212> DNA
<213> Artificial Sequence


<220> 
<223> fusion

<400> 18
atgaagatcg aggaaggcaa gctcgtgatc tggatcaacg gcgacaaggg ctacaacggc      60

ctggccgagg tgggcaagaa gttcgagaag gacaccggca tcaaggtgac ggtggagcac     120

ccggacaagc tcgaggagaa gttcccgcag gtggcggcca cgggcgacgg cccggacatc     180

atcttctggg cccatgaccg cttcggcggc tacgcccagt cgggcctgct ggccgagatc     240

accccggaca aggcgttcca ggacaagctc tatcccttca cgtgggacgc cgtgcgctac     300

aacggcaagc tgatcgcgta tcccatcgcg gtggaggccc tgtcgctcat ctataacaag     360

gacctgctcc cgaacccgcc caagacctgg gaggagatcc ccgccctcga caaggagctg     420

aaggccaagg gcaagtcggc gctcatgttc aacctgcagg agccgtactt cacctggccc     480

ctgatcgcgg ccgacggcgg ctacgcgttc aagtatgaga acggcaagta tgacatcaag     540

gacgtgggcg tggacaacgc gggcgccaag gccggcctga ccttcctcgt ggacctgatc     600

aagaacaagc acatgaacgc cgacacggac tactcgatcg cggaggccgc gttcaacaag     660

ggcgagactg ccatgacgat caacggcccg tgggcgtggt cgaacatcga cacctcgaag     720

gtgaactatg gcgtgaccgt gctccccacg ttcaagggcc agccctcgaa gcccttcgtg     780

ggcgtgctgt cggcgggcat caacgccgcg tcgccgaaca aggagctcgc gaaggagttc     840

ctggagaact acctgctcac cgacgagggc ctggaggccg tgaacaagga caagcccctg     900

ggcgccgtgg ccctgaagtc gtatgaggaa gagctggtga aggacccgcg catcgcggcc     960

accatggaga acgcgcagaa gggcgagatc atgccgaaca tcccccagat gtcggccttc    1020

tggtatgcgg tgcgcaccgc cgtgatcaac gcggcctcgg gccgccagac cgtggacgag    1080

gccctcaagg acgcccagac cggcggaggt gctgccatgg agaagaagtc gttcggctcg    1140

atgtgcatcg acgacgacat caccaagatc aagatgctct tctcggagat caagcgccgc    1200

tactcgtcgc tctcggccta cgacaccgtg cacggcgcct acccgatcaa cctcatcctc    1260

ggcctctcga tggtgaacca cctcgagtcg ctcggcatcg cccgccactt caagctcgag    1320

atcaaggagg tgctcgacga cgtgtaccgc ttctggatcg agaacgagat ggtggagggc    1380

atgccgtcgg cctcggacat catgacctcg tcgatctcgt tccgcatcct ccgctggaac    1440

ggctacgacg tgtcgccgga cgtgttcttc tcgtacctcc gcgactcgga cttcctcctc    1500

ttcctcgaga actcggacca ggccaccatc gccctcctca acctctacaa ggcctcgcag    1560

atgatgttcc cgggcgagcg catcctcgag gaggccaagc tcttctcgca gaactacctc    1620

gagaacatca agatgggcaa ccagtcgggc gccctcaagg acatcgaggc cgaggtgaag    1680

cacgccctcg acgtgccgtg gatggccaac ctcgagcgca tcgagcacct ccgctacatg    1740

aaggccttcg ccttcgacaa catctggatc ggcgagacgt cgtcgcgcat cccgttcacc    1800

ggcaaggacc tcttcctctc gttcgccaag caggacttca acatctgcca ggccgcccag    1860

caggaggacc tcaaggccct cgagaagtgg tcggtggact cgaagctcgg cgacctccac    1920

ttcgcccgcc agaagctcgt ggcctgctac ttctcggccg cctcgatcct cttctcgccg    1980

gagatgtcgg ccacccgcat cgtgtggacc aagaacgccg tgctcatcac cctcatggac    2040

gacttctacg acgtggaggg ctcgatcgag gacatccagt cgttcgtgga ggccgtgaag    2100

cgctgggacc cgatcgtgct ctgcaactgc tcggccaacg tgaagatcct cttctcggcc    2160

atctacaaca ccgtgaacga catcgcccag gacatctgga tcttccaggg ctgggacatc    2220

tcgacccagc tccgcgagat ctggtacgag ctcgccatct cgatgatgaa ggaggccgag    2280

tggaccaaga ccggcttcat cccgtcgctc gaggagtaca tggagaacgg ccgcacctcg    2340

atcgccctcg agccgatcat cttcacctcg ctcttcttca tcggcccgaa gctctcggag    2400

cagatgatcc accaccacga gtacaagcgc ctcctccagc tcatgaacac ctgcggccgc    2460

ctcctcaacg acatccagtc ggacaagcgc gagatgaagc agggcaagct cacctcggtg    2520

tcgctcttcg tgaaggagta cccgatcgag gacgccacca agtggatccg cctcaccgtg    2580

tcggagaaca cccagaacat cctcaagaag atcctccagc cgtcggagat cccgcgcgag    2640

tgcaagcaga tcttctggaa catggtgaag atcatccagc tcttctgcct ccactcggac    2700

gagttcacct cgccgaccac catgctcgag cacatgaagg ccgtgctctt ctacccggtg    2760

ctctga                                                               2766


<210> 19
<211> 1578
<212> DNA
<213> Salvia sclarea


<400> 19
atggccaaga tgaaggagaa cttcaagcgc gaggacgaca agttcccgac caccaccacc      60

ctccgctcgg aggacatccc gtcgaacctc tgcatcatcg acaccctcca gcgcctcggc     120

gtggaccagt tcttccagta cgagatcaac accatcctcg acaacacctt ccgcctctgg     180

caggagaagc acaaggtgat ctacggcaac gtgaccaccc acgccatggc cttccgcctc     240

ctccgcgtga agggctacga ggtgtcgtcg gaggagctcg ccccgtacgg caaccaggag     300

gccgtgtcgc agcagaccaa cgacctcccg atgatcatcg agctctaccg cgccgccaac     360

gagcgcatct acgaggagga gcgctcgctc gagaagatcc tcgcctggac caccatcttc     420

ctcaacaagc aggtgcagga caactcgatc ccggacaaga agctccacaa gctcgtggag     480

ttctacctcc gcaactacaa gggcatcacc atccgcctcg gcgcccgccg caacctcgag     540

ctctacgaca tgacctacta ccaggccctc aagtcgacca accgcttctc gaacctctgc     600

aacgaggact tcctcgtgtt cgccaagcag gacttcgaca tccacgaggc ccagaaccag     660

aagggcctcc agcagctcca gcgctggtac gccgactgcc gcctcgacac cctcaacttc     720

ggccgcgacg tggtgatcat cgccaactac ctcgcctcgc tcatcatcgg cgaccacgcc     780

ttcgactacg tgcgcctcgc cttcgccaag acctcggtgc tcgtgaccat catggacgac     840

ttcttcgact gccacggctc gtcgcaggag tgcgacaaga tcatcgagct cgtgaaggag     900

tggaaggaga acccggacgc cgagtacggc tcggaggagc tcgagatcct cttcatggcc     960

ctctacaaca ccgtgaacga gctcgccgag cgcgcccgcg tggagcaggg ccgctcggtg    1020

aaggagttcc tcgtgaagct ctgggtggag atcctctcgg ccttcaagat cgagctcgac    1080

acctggtcga acggcaccca gcagtcgttc gacgagtaca tctcgtcgtc gtggctctcg    1140

aacggctcgc gcctcaccgg cctcctcacc atgcagttcg tgggcgtgaa gctctcggac    1200

gagatgctca tgtcggagga gtgcaccgac ctcgcccgcc acgtgtgcat ggtgggccgc    1260

ctcctcaacg acgtgtgctc gtcggagcgc gagcgcgagg agaacatcgc cggcaagtcg    1320

tactcgatcc tcctcgccac cgagaaggac ggccgcaagg tgtcggagga cgaggccatc    1380

gccgagatca acgagatggt ggagtaccac tggcgcaagg tgctccagat cgtgtacaag    1440

aaggagtcga tcctcccgcg ccgctgcaag gacgtgttcc tcgagatggc caagggcacc    1500

ttctacgcct acggcatcaa cgacgagctc acctcgccgc agcagtcgaa ggaggacatg    1560

aagtcgttcg tgttctga                                                  1578


<210> 20
<211> 2550
<212> DNA
<213> Artificial Sequence


<220> 
<223> fusion

<400> 20
atgtcggaca agatcatcca cctgaccgac gacagcttcg acaccgacgt gctgaaggcc      60

gacggcgcca tcctcgtcga tttctgggcc gaatggtgcg gcccctgcaa gatgatcgcg     120

ccgatcctcg acgagatcgc cgacgaatat cagggcaagc tgaccgtcgc caagctgaac     180

atcgaccaga acccgggcac ggcgccgaaa tacggcatcc gcggcatccc gacgctgctg     240

ctcttcaaga acggcgaggt ggcggccacc aaggtcggcg cgctgtcgaa gggccagctg     300

aaggagttcc tcgatgcgaa cctcgccggt ggtgatgacg acgacaagat tcatatgtgc     360

cgcgtggcct cgctcgacgc cctcaacggc atccagaagg tgggcccggc caccatcggc     420

accccggagg aggagaacaa gaagatcgag gactcgatcg agtacgtgaa ggagctcctc     480

aagaccatgg gcgacggccg catctcggtg tcgccgtacg acaccgccat cgtggccctc     540

atcaaggacc tcgagggcgg cgacggcccg gagttcccgt cgtgcctcga gtggatcgcc     600

cagaaccagc tcgccgacgg ctcgtggggc gaccacttct tctgcatcta cgaccgcgtg     660

gtgaacaccg ccgcctgcgt ggtggccctc aagtcgtgga acgtgcacgc cgacaagatc     720

gagaagggcg ccgtgtacct caaggagaac gtgcacaagc tcaaggacgg caagatcgag     780

cacatgccgg ccggcttcga gttcgtggtg ccggccaccc tcgagcgcgc caaggccctc     840

ggcatcaagg gcctcccgta cgacgacccg ttcatccgcg agatctactc ggccaagcag     900

acccgcctca ccaagatccc gaagggcatg atctacgagt cgccgacctc gctcctctac     960

tcgctcgacg gcctcgaggg cctcgagtgg gacaagatcc tcaagctcca gtcggccgac    1020

ggctcgttca tcacctcggt gtcgtcgacc gccttcgtgt tcatgcacac caacgacctc    1080

aagtgccacg ccttcatcaa gaacgccctc accaactgca acggcggcgt gccgcacacc    1140

tacccggtgg acatcttcgc ccgcctctgg gccgtggacc gcctccagcg cctcggcatc    1200

tcgcgcttct tcgagccgga gatcaagtac ctcatggacc acatcaacaa cgtgtggcgc    1260

gagaagggcg tgttctcgtc gcgccactcg cagttcgccg acatcgacga cacctcgatg    1320

ggcatccgcc tcctcaagat gcacggctac aacgtgaacc cgaacgccct cgagcacttc    1380

aagcagaagg acggcaagtt cacctgctac gccgaccagc acatcgagtc gccgtcgccg    1440

atgtacaacc tctaccgcgc cgcccagctc cgcttcccgg gcgaggagat cctccagcag    1500

gccctccagt tcgcctacaa cttcctccac gagaacctcg cctcgaacca cttccaggag    1560

aagtgggtga tctcggacca cctcatcgac gaggtgcgca tcggcctcaa gatgccgtgg    1620

tacgccaccc tcccgcgcgt ggaggcctcg tactacctcc agcactacgg cggctcgtcg    1680

gacgtgtgga tcggcaagac cctctaccgc atgccggaga tctcgaacga cacctacaag    1740

atcctcgccc agctcgactt caacaagtgc caggcccagc accagctcga gtggatgtcg    1800

atgaaggagt ggtaccagtc gaacaacgtg aaggagttcg gcatctcgaa gaaggagctc    1860

ctcctcgcct acttcctcgc cgccgccacc atgttcgagc cggagcgcac ccaggagcgc    1920

atcatgtggg ccaagaccca ggtggtgtcg cgcatgatca cctcgttcct caacaaggag    1980

aacaccatgt cgttcgacct caagatcgcc ctcctcaccc agccgcagca ccagatcaac    2040

ggctcggaga tgaagaacgg cctcgcccag accctcccgg ccgccttccg ccagctcctc    2100

aaggagttcg acaagtacac ccgccaccag ctccgcaaca cctggaacaa gtggctcatg    2160

aagctcaagc agggcgacga caacggcggc gccgacgccg agctcctcgc caacaccctc    2220

aacatctgcg ccggccacaa cgaggacatc ctctcgcact acgagtacac cgccctctcg    2280

tcgctcacca acaagatctg ccagcgcctc tcgcagatcc aggacaagaa gatgctcgag    2340

atcgaggagg gctcgatcaa ggacaaggag atggagctcg agatccagac cctcgtgaag    2400

ctcgtgctcc aggagacgtc gggcggcatc gaccgcaaca tcaagcagac cttcctctcg    2460

gtgttcaaga ccttctacta ccgcgcctac cacgacgcca agaccatcga cgcccacatc    2520

ttccaggtgc tcttcgagcc ggtggtgtga                                     2550


<210> 21
<211> 2595
<212> DNA
<213> Artificial Sequence


<220> 
<223> fusion

<400> 21
atgtcggaca agatcatcca cctgaccgac gacagcttcg acaccgacgt gctgaaggcc      60

gacggcgcca tcctcgtcga tttctgggcc gaatggtgcg gcccctgcaa gatgatcgcg     120

ccgatcctcg acgagatcgc cgacgaatat cagggcaagc tgaccgtcgc caagctgaac     180

atcgaccaga acccgggcac ggcgccgaaa tacggcatcc gcggcatccc gacgctgctg     240

ctcttcaaga acggcgaggt ggcggccacc aaggtcggcg cgctgtcgaa gggccagctg     300

aaggagttcc tcgatgcgaa cctcgccggt ggtgatgacg acgacaagat tcatatgaac     360

aacggcaaga acctcaactg ccagctcacc cacaagaaga tctcgaaggt ggccgagatc     420

cgcgtggcca ccgtgaacgc cccgccggtg cacgaccagg acgactcgac cgagaaccag     480

tgccacgacg ccgtgaacaa catcgaggac ccgatcgagt acatccgcac cctcctccgc     540

accaccggcg acggccgcat ctcggtgtcg ccgtacgaca ccgcctgggt ggccctcatc     600

aaggacctcc agggccgcga cgccccggag ttcccgtcgt cgctcgagtg gatcatccag     660

aaccagctcg ccgacggctc gtggggcgac gccaagttct tctgcgtgta cgaccgcctc     720

gtgaacacca tcgcctgcgt ggtggccctc cgctcgtggg acgtgcacgc cgagaaggtg     780

gagcgcggcg tgcgctacat caacgagaac gtggagaagc tccgcgacgg caacgaggag     840

cacatgacct gcggcttcga ggtggtgttc ccggccctcc tccagcgcgc caagtcgctc     900

ggcatccagg acctcccgta cgacgccccg gtgatccagg agatctacca ctcgcgcgag     960

cagaagtcga agcgcatccc gctcgagatg atgcacaagg tgccgacctc gctcctcttc    1020

tcgctcgagg gcctcgagaa cctcgagtgg gacaagctcc tcaagctcca gtcggccgac    1080

ggctcgttcc tcacctcgcc gtcgtcgacc gccttcgcct tcatgcagac ccgcgacccg    1140

aagtgctacc agttcatcaa gaacaccatc cagaccttca acggcggcgc cccgcacacc    1200

tacccggtgg acgtgttcgg ccgcctctgg gccatcgacc gcctccagcg cctcggcatc    1260

tcgcgcttct tcgagtcgga gatcgccgac tgcatcgccc acatccaccg cttctggacc    1320

gagaagggcg tgttctcggg ccgcgagtcg gagttctgcg acatcgacga cacctcgatg    1380

ggcgtgcgcc tcatgcgcat gcacggctac gacgtggacc cgaacgtgct caagaacttc    1440

aagaaggacg acaagttctc gtgctacggc ggccagatga tcgagtcgcc gtcgccgatc    1500

tacaacctct accgcgcctc gcagctccgc ttcccgggcg agcagatcct cgaggacgcc    1560

aacaagttcg cctacgactt cctccaggag aagctcgccc acaaccagat cctcgacaag    1620

tgggtgatct cgaagcacct cccggacgag atcaagctcg gcctcgagat gccgtggtac    1680

gccaccctcc cgcgcgtgga ggcccgctac tacatccagt actacgccgg ctcgggcgac    1740

gtgtggatcg gcaagaccct ctaccgcatg ccggagatct cgaacgacac ctaccacgag    1800

ctcgccaaga ccgacttcaa gcgctgccag gcccagcacc agttcgagtg gatctacatg    1860

caggagtggt acgagtcgtg caacatggag gagttcggca tctcgcgcaa ggagctcctc    1920

gtggcctact tcctcgccac cgcctcgatc ttcgagctcg agcgcgccaa cgagcgcatc    1980

gcctgggcca agtcgcagat catctcgacc atcatcgcct cgttcttcaa caaccagaac    2040

acctcgccgg aggacaagct cgccttcctc accgacttca agaacggcaa ctcgaccaac    2100

atggccctcg tgaccctcac ccagttcctc gagggcttcg accgctacac ctcgcaccag    2160

ctcaagaacg cctggtcggt gtggctccgc aagctccagc agggcgaggg caacggcggc    2220

gccgacgccg agctcctcgt gaacaccctc aacatctgcg ccggccacat cgccttccgc    2280

gaggagatcc tcgcccacaa cgactacaag accctctcga acctcacctc gaagatctgc    2340

cgccagctct cgcagatcca gaacgagaag gagctcgaga cggagggcca gaagacctcg    2400

atcaagaaca aggagctcga ggaggacatg cagcgcctcg tgaagctcgt gctcgagaag    2460

tcgcgcgtgg gcatcaaccg cgacatgaag aagaccttcc tcgccgtggt gaagacctac    2520

tactacaagg cctaccactc ggcccaggcc atcgacaacc acatgttcaa ggtgctcttc    2580

gagccggtgg cctga                                                     2595


<210> 22
<211> 1101
<212> DNA
<213> Cupressus gigantea


<400> 22
atgtcgtcgt tcgacgccca cgacctcgac ctcgacaagt tcccggaggt ggtgcgcgac      60

cgcctcaccc agttcctcga cgcccaggag ctcaccatcg ccgacatcgg cgccccggtg     120

accgacgccg tggcccacct ccgctcgttc gtgctcaacg gcggcaagcg catccgcccg     180

ctctacgcct gggccggctt cctcgccgcc cagggccaca agaactcgtc ggagaagctc     240

gagtcggtgc tcgacgccgc cgcctcgctc gagttcatcc aggcctgcgc cctcatccac     300

gacgacatca tcgactcgtc ggacacccgc cgcggcgccc cgaccgtgca ccgcgccgtg     360

gaggccgacc accgcgccaa caacttcgag ggcgacccgg agcacttcgg cgtgtcggtg     420

tcgatcctcg ccggcgacat ggccctcgtg tgggccgagg acatgctcca ggactcgggc     480

ctctcggccg aggccctcgc ccgcacccgc gacgcctggc gcggcatgcg caccgaggtg     540

atcggcggcc agctcctcga catctacctc gagtcgcacg ccaacgagtc ggtggagctc     600

gccgactcgg tgaaccgctt caagaccgcc gcctacacca tcgcccgccc gctccacctc     660

ggcgcctcga tcgccggcgg ctcgccgcag ctcatcgacg ccctcctcca ctacggccac     720

gacatcggca tcgccttcca gctccgcgac gacctcctcg gcgtgttcgg cgacccggcc     780

atcaccggca agccggccgg cgacgacatc cgcgagggca agcgcaccgt gctcctcgcc     840

ctcgccctcc agcgcgccga caagcagtcg ccggaggccg ccaccgccat ccgcgccggc     900

gtgggcaagg tgacctcgcc ggaggacatc gccgtgatca ccgagcacat ccgcgccacc     960

ggcgccgagg aggaggtgga gcagcgcatc tcgcagctca ccgagtcggg cctcgcccac    1020

ctcgacgacg tggacatccc ggacgaggtg cgcgcccagc tccgcgccct cgccatccgc    1080

tcgaccgagc gccgcatgtg a                                              1101


<210> 23
<211> 2763
<212> DNA
<213> Artificial Sequence


<220> 
<223> fusion

<400> 23
atgtcggaca agatcatcca cctgaccgac gacagcttcg acaccgacgt gctgaaggcc      60

gacggcgcca tcctcgtcga tttctgggcc gaatggtgcg gcccctgcaa gatgatcgcg     120

ccgatcctcg acgagatcgc cgacgaatat cagggcaagc tgaccgtcgc caagctgaac     180

atcgaccaga acccgggcac ggcgccgaaa tacggcatcc gcggcatccc gacgctgctg     240

ctcttcaaga acggcgaggt ggcggccacc aaggtcggcg cgctgtcgaa gggccagctg     300

aaggagttcc tcgatgcgaa cctcgccggt ggtgatgacg acgacaagat tcatatgcag     360

gtgatcatca cctcgtcgca ccgcttcttc tgccaccacc tccaccagct caagtcgccg     420

acctcgctct cggcccagaa ggccgagttc aagaagcacg gcccgcgcaa ctggctcttc     480

cagaccgagg gctcgctcct ctacaagccg gtgcgcctca actgcgccac ctcggacgcc     540

tcgtacctcg gcaacgtgaa cgagtacctc gagtcggacc actcgaagaa ctcggaggag     600

aaggacatcc aggtgtcgcg caccatccag atgaagggcc tcaccgagga gatcaagcac     660

atgctcaact cgatggagga cggccgcctc aacgtgctcg cctacgacac cgcctgggtg     720

tcgttcatcc cgaacaccac caacaacggc aacgaccagc gcccgatgtt cccgtcgtgc     780

ctccagtgga tcatcgacaa ccagctctcg gacggctcgt ggggcgagga gatcgtgttc     840

tgcatctacg accgcctcct caacaccctc gtgtgcgtga tcgccctcac cctctggaac     900

acctgcctcc acaagcgcaa caagggcgtg atgttcatca aggagaacct ctcgaagctc     960

gagacgggcg aggtggagaa catgacctcg ggcttcgagc tcgtgttccc gaccctcctc    1020

gagaaggccc agcagctcga catcgacatc ccgtacgacg ccccggtgct caaggacatc    1080

tacgcccgcc gcgaggtgaa gctcacccgc atcccgaagg acgtgatcca caccatcccg    1140

accaccgtgc tcttctcgct cgagggcctc cgcgacgacc tcgactggca gcgcctcctc    1200

aagctccaga tgccggacgg ctcgttcctc atctcgccgg cctcgaccgc cttcgccttc    1260

atggagacga acgacgagaa gtgcctcgcc tacctccaga acgtggtgga gaagtcgaac    1320

ggcggcgccc gccagtaccc gttcgacctc gtgacccgcc tctgggccat cgaccgcctc    1380

cagcgcctcg gcatctcgta ctacttcgcc gaggagttca aggagctcct caaccacgtg    1440

ttccgctact gggacgagga gaacggcatc ttctcgggcc gcaactcgaa cgtgtcggac    1500

gtggacgaca cctgcatggc catccgcctc ctccgcctcc acggctacga cgtgtcgccg    1560

gacgccctca acaacttcaa ggacggcgac cagttcgtgt gcttccgcgg cgaggtggac    1620

ggctcgccga cccacatgtt caacctctac cgctgctcgc aggtgctctt cccgggcgag    1680

aagatcctcg aggaggccaa gaacttcacc tacaacttcc tccagcagtg cctcgccaac    1740

aaccgctgcc tcgacaagtg ggtgatcgcc aaggacatcc cgggcgagat ctggtacgcc    1800

ctcgagttcc cgtggtacgc ctcgctcccg cgcgtggagg cccgctacta catcgagcag    1860

tacggcggcg ccgacgacat ctggatcggc aagaccctct accgcatgcc ggacgtgaac    1920

aacaacgtgt acctccaggc cgccaagctc gactacaacc gctgccagtc gcagcaccgc    1980

ttcgagtggc tcatcatgca ggagtggttc gagaagtgca acttccagca gttcggcatc    2040

tcgaagaagt acctcctcgt gtcgtacttc ctcgccgccg cctcgatctt cgaggtggag    2100

aagtcgcgcg agcgcctcgc ctgggccaag tcgcgcatca tctgcaagat gatcacctcg    2160

tactacaacg acgaggccac cacctggacc acccgcaact cgctcctcat ggagttcaag    2220

gtgtcgcacg acccgacccg caagaacggc aacgagacga aggagatcct cgtgctcaag    2280

aacctccgcc agttcctccg ccagctctcg gaggagacgt tcgaggacct cggcaaggac    2340

atccaccacc agctccagaa cgcctgggag acgtggctcg tgttcctccg cgaggagaag    2400

aacgcctgcc aggaggagac ggagctcctc gtgcgcacca tcaacctctc gggcggctac    2460

atgacccacg acgagatcct cttcgacgcc gactacgaga acctctcgaa cctcaccaac    2520

aaggtgtgcg gcaagctcaa cgagctccag aacgacaagg tgaccggcgg ctcgaagaac    2580

accaacatcg agctcgacat gcaggccctc gtgaagctcg tgttcggcaa cacctcgtcg    2640

aacatcaacc aggacatcaa gcagaccttc ttcgccgtgg tgaagacctt ctactactcg    2700

gcccacgtgt cggaggagat catgaacttc cacatctcga aggtgctctt ccagcaggtg    2760

tga                                                                  2763


<210> 24
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> domain

<400> 24
Gly Arg Thr Ser Ile Ala Leu Glu Pro Ile Ile Phe 
1               5                   10          

<210> 25
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> domain

<400> 25
Ser Trp Val Ser Ile Gly Cys Arg Ile Cys Ile Leu 
1               5                   10          

<210> 26
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> domain

<400> 26
Ser Trp Leu Ser Asn Gly Ser Arg Leu Thr Gly Leu 
1               5                   10          

<210> 27
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> domain

<400> 27
Ser Trp Leu Ser Ile Gly Ser Arg Leu Thr Gly Leu 
1               5                   10          

<210> 28
<211> 940
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 28
Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      
Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          
Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              
Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  
His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  
Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      
Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         
Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             
Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 
Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 
Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     
Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         
Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             
Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 
Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 
Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     
Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         
Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             
Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 
Leu Lys Ser Tyr Glu Glu Glu Leu Val Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 
Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     
Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         
Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Gly 
        355                 360                 365             
Gly Gly Ala Ala Met Leu Ser Val Glu Asp Ser Ser Asn Val Leu Ile 
    370                 375                 380                 
Lys Ala Glu Lys Glu Asn Arg Glu Lys Lys Ser Phe Gly Ser Met Cys 
385                 390                 395                 400 
Ile Asp Asp Asn Ile Thr Arg Ile Asn Met Leu Phe Leu Glu Ile Lys 
                405                 410                 415     
Arg Arg Tyr Ser Ser Leu Ser Ala Tyr Asp Thr Val His Gly Ala Tyr 
            420                 425                 430         
Pro Ile Asn Leu Ile Leu Gly Leu Ser Met Val Asn His Leu Glu Ser 
        435                 440                 445             
Leu Gly Ile Ala Arg His Phe Lys Leu Glu Ile Lys Glu Val Leu Asp 
    450                 455                 460                 
Asp Val Tyr Arg Phe Trp Ile Glu Asn Glu Met Val Lys Gly Met Pro 
465                 470                 475                 480 
Ser Ala Ser Asp Ile Met Thr Ser Ser Ile Ser Phe Lys Ile Leu Arg 
                485                 490                 495     
Trp Asn Gly Tyr Asp Val Ser Pro Asp Val Phe Phe Ser Tyr Leu Arg 
            500                 505                 510         
Asp Ser Asp Phe Leu Pro Phe Leu Glu Asn Ser Gly Gln Ala Thr Met 
        515                 520                 525             
Ala Leu Leu Asn Leu Tyr Lys Ala Ser Gln Met Met Phe Pro Gly Glu 
    530                 535                 540                 
Arg Ile Leu Glu Glu Ala Lys Ser Phe Ser Gln Asn Tyr Leu Glu Asn 
545                 550                 555                 560 
Ile Lys Val Gly Asp Gln Ser Gly Ala Leu Lys Asp Ile Glu Ala Glu 
                565                 570                 575     
Val Lys His Ala Leu Asp Val Pro Trp Met Ala Gly Leu Glu Arg Ile 
            580                 585                 590         
Glu His Leu Arg Tyr Met Lys Ala Phe Ala Phe Asp Asp Ile Trp Ile 
        595                 600                 605             
Gly Glu Thr Ser Ser Arg Ile Pro Phe Thr Gly Lys Asp Leu Phe Leu 
    610                 615                 620                 
Ser Leu Ala Lys Gln Asp Phe Asn Ile Cys Gln Glu Ala Gln Gln Glu 
625                 630                 635                 640 
Asp Leu Lys Ala Leu Glu Lys Trp Ser Val Asp Ser Lys Leu Gly Asp 
                645                 650                 655     
Leu His Phe Ala Arg Gln Lys Leu Val Ala Cys Tyr Phe Ser Ala Ala 
            660                 665                 670         
Ser Thr Leu Phe Ser Pro Glu Met Ser Thr Thr Arg Ile Val Trp Thr 
        675                 680                 685             
Lys Asn Ala Val Leu Thr Thr Leu Met Asp Asp Phe Tyr Asp Val Glu 
    690                 695                 700                 
Gly Ser Ile Glu Asp Ile Gln Ser Phe Val Glu Ala Val Lys Arg Trp 
705                 710                 715                 720 
Asp Pro Ile Val Leu Cys Asn Cys Ser Ala Asn Val Lys Lys Leu Phe 
                725                 730                 735     
Ser Ala Ile Tyr Asn Thr Val Asn Asp Ile Ala Gln Asp Ile Trp Ile 
            740                 745                 750         
Phe Gln Gly Trp Asp Ile Ser Thr Gln Leu Arg Glu Ile Trp Tyr Glu 
        755                 760                 765             
Leu Ala Ile Ser Met Met Lys Glu Ala Glu Trp Thr Lys Thr Gly Phe 
    770                 775                 780                 
Ile Pro Ser Leu Glu Glu Tyr Met Glu Asn Gly Arg Thr Ser Ile Ala 
785                 790                 795                 800 
Leu Glu Pro Ile Ile Phe Thr Ser Leu Phe Phe Leu Gly Pro Lys Leu 
                805                 810                 815     
Ser Glu Gln Met Ile His Glu Tyr Lys Arg Leu Met Gln Leu Leu Asn 
            820                 825                 830         
Thr Cys Gly Arg Leu Leu Asn Asp Ser Gln Ser Tyr Lys Arg Glu Ile 
        835                 840                 845             
Lys Gln Gly Lys Leu Asn Ser Leu Ser Leu Phe Val Lys Glu Tyr Pro 
    850                 855                 860                 
Ala Thr Ser Ile Glu Asp Ala Thr Glu Trp Ile Arg Leu Thr Val Ser 
865                 870                 875                 880 
Glu Ser Arg Gln Asn Ile Leu Arg Asn Leu Leu Gln Pro Ser Glu Ile 
                885                 890                 895     
Pro Arg Glu Cys Lys Gln Ile Phe Trp Asn Met Val Lys Ile Ile Gln 
            900                 905                 910         
Leu Phe Tyr Leu His Ser Asp Glu Phe Thr Ser Pro Thr Ala Met Leu 
        915                 920                 925             
Glu His Met Gln Ala Val Leu Phe Asn Pro Val Leu 
    930                 935                 940 

<210> 29
<211> 964
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 29
Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      
Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          
Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              
Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  
His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  
Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      
Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         
Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             
Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 
Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 
Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     
Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         
Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             
Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 
Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 
Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     
Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         
Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             
Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 
Leu Lys Ser Tyr Glu Glu Glu Leu Val Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 
Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     
Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         
Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Gly 
        355                 360                 365             
Gly Gly Ala Ala Met Ala Gly Ala Ser Asn Phe Asn Phe Asn Gly Arg 
    370                 375                 380                 
Lys Lys Phe Asn Pro Arg Thr His Gln Lys Val Lys Ser Leu Ser Val 
385                 390                 395                 400 
Glu Asp Ser Ser Asn Val Leu Ile Lys Ala Glu Lys Glu Asn Arg Glu 
                405                 410                 415     
Lys Lys Ser Phe Gly Ser Met Cys Ile Asp Asp Asn Ile Thr Arg Ile 
            420                 425                 430         
Asn Met Leu Phe Leu Glu Ile Lys Arg Arg Tyr Ser Ser Leu Ser Ala 
        435                 440                 445             
Tyr Asp Thr Val His Gly Ala Tyr Pro Ile Asn Leu Ile Leu Gly Leu 
    450                 455                 460                 
Ser Met Val Asn His Leu Glu Ser Leu Gly Ile Ala Arg His Phe Lys 
465                 470                 475                 480 
Leu Glu Ile Lys Glu Val Leu Asp Asp Val Tyr Arg Phe Trp Ile Glu 
                485                 490                 495     
Asn Glu Met Val Lys Gly Met Pro Ser Ala Ser Asp Ile Met Thr Ser 
            500                 505                 510         
Ser Ile Ser Phe Lys Ile Leu Arg Trp Asn Gly Tyr Asp Val Ser Pro 
        515                 520                 525             
Asp Val Phe Phe Ser Tyr Leu Arg Asp Ser Asp Phe Leu Pro Phe Leu 
    530                 535                 540                 
Glu Asn Ser Gly Gln Ala Thr Met Ala Leu Leu Asn Leu Tyr Lys Ala 
545                 550                 555                 560 
Ser Gln Met Met Phe Pro Gly Glu Arg Ile Leu Glu Glu Ala Lys Ser 
                565                 570                 575     
Phe Ser Gln Asn Tyr Leu Glu Asn Ile Lys Val Gly Asp Gln Ser Gly 
            580                 585                 590         
Ala Leu Lys Asp Ile Glu Ala Glu Val Lys His Ala Leu Asp Val Pro 
        595                 600                 605             
Trp Met Ala Gly Leu Glu Arg Ile Glu His Leu Arg Tyr Met Lys Ala 
    610                 615                 620                 
Phe Ala Phe Asp Asp Ile Trp Ile Gly Glu Thr Ser Ser Arg Ile Pro 
625                 630                 635                 640 
Phe Thr Gly Lys Asp Leu Phe Leu Ser Leu Ala Lys Gln Asp Phe Asn 
                645                 650                 655     
Ile Cys Gln Glu Ala Gln Gln Glu Asp Leu Lys Ala Leu Glu Lys Trp 
            660                 665                 670         
Ser Val Asp Ser Lys Leu Gly Asp Leu His Phe Ala Arg Gln Lys Leu 
        675                 680                 685             
Val Ala Cys Tyr Phe Ser Ala Ala Ser Thr Leu Phe Ser Pro Glu Met 
    690                 695                 700                 
Ser Thr Thr Arg Ile Val Trp Thr Lys Asn Ala Val Leu Thr Thr Leu 
705                 710                 715                 720 
Met Asp Asp Phe Tyr Asp Val Glu Gly Ser Ile Glu Asp Ile Gln Ser 
                725                 730                 735     
Phe Val Glu Ala Val Lys Arg Trp Asp Pro Ile Val Leu Cys Asn Cys 
            740                 745                 750         
Ser Ala Asn Val Lys Lys Leu Phe Ser Ala Ile Tyr Asn Thr Val Asn 
        755                 760                 765             
Asp Ile Ala Gln Asp Ile Trp Ile Phe Gln Gly Trp Asp Ile Ser Thr 
    770                 775                 780                 
Gln Leu Arg Glu Ile Trp Tyr Glu Leu Ala Ile Ser Met Met Lys Glu 
785                 790                 795                 800 
Ala Glu Trp Thr Lys Thr Gly Phe Ile Pro Ser Leu Glu Glu Tyr Met 
                805                 810                 815     
Glu Asn Gly Arg Thr Ser Ile Ala Leu Glu Pro Ile Ile Phe Thr Ser 
            820                 825                 830         
Leu Phe Phe Leu Gly Pro Lys Leu Ser Glu Gln Met Ile His Glu Tyr 
        835                 840                 845             
Lys Arg Leu Met Gln Leu Leu Asn Thr Cys Gly Arg Leu Leu Asn Asp 
    850                 855                 860                 
Ser Gln Ser Tyr Lys Arg Glu Ile Lys Gln Gly Lys Leu Asn Ser Leu 
865                 870                 875                 880 
Ser Leu Phe Val Lys Glu Tyr Pro Ala Thr Ser Ile Glu Asp Ala Thr 
                885                 890                 895     
Glu Trp Ile Arg Leu Thr Val Ser Glu Ser Arg Gln Asn Ile Leu Arg 
            900                 905                 910         
Asn Leu Leu Gln Pro Ser Glu Ile Pro Arg Glu Cys Lys Gln Ile Phe 
        915                 920                 925             
Trp Asn Met Val Lys Ile Ile Gln Leu Phe Tyr Leu His Ser Asp Glu 
    930                 935                 940                 
Phe Thr Ser Pro Thr Ala Met Leu Glu His Met Gln Ala Val Leu Phe 
945                 950                 955                 960 
Asn Pro Val Leu 
                

<210> 30
<211> 964
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 30
Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      
Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          
Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              
Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  
His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  
Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      
Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         
Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             
Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 
Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 
Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     
Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         
Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             
Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 
Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 
Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     
Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         
Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             
Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 
Leu Lys Ser Tyr Glu Glu Glu Leu Val Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 
Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     
Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         
Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Gly 
        355                 360                 365             
Gly Gly Ala Ala Met Ala Gly Ala Ser Asn Phe Asn Phe Asn Gly Arg 
    370                 375                 380                 
Lys Lys Phe Asn Pro Arg Thr His Gln Lys Val Lys Ser Leu Ser Arg 
385                 390                 395                 400 
Arg Asp Ser Ser Asn Val Leu Ile Lys Trp Glu Lys Glu Asn Arg Glu 
                405                 410                 415     
Lys Lys Ser Phe Gly Ser Met Cys Ile Asp Asp Asn Ile Thr Arg Ile 
            420                 425                 430         
Asn Met Leu Phe Leu Glu Ile Lys Arg Arg Tyr Ser Ser Leu Ser Ala 
        435                 440                 445             
Tyr Asp Thr Val His Gly Ala Tyr Pro Ile Asn Leu Ile Leu Gly Leu 
    450                 455                 460                 
Ser Met Val Asn His Leu Glu Ser Leu Gly Ile Ala Arg His Phe Lys 
465                 470                 475                 480 
Leu Glu Ile Lys Glu Val Leu Asp Asp Val Tyr Arg Phe Trp Ile Glu 
                485                 490                 495     
Asn Glu Met Val Lys Gly Met Pro Ser Ala Ser Asp Ile Met Thr Ser 
            500                 505                 510         
Ser Ile Ser Phe Lys Ile Leu Arg Trp Asn Gly Tyr Asp Val Ser Pro 
        515                 520                 525             
Asp Val Phe Phe Ser Tyr Leu Arg Asp Ser Asp Phe Leu Pro Phe Leu 
    530                 535                 540                 
Glu Asn Ser Gly Gln Ala Thr Met Ala Leu Leu Asn Leu Tyr Lys Ala 
545                 550                 555                 560 
Ser Gln Met Met Phe Pro Gly Glu Arg Ile Leu Glu Glu Ala Lys Ser 
                565                 570                 575     
Phe Ser Gln Asn Tyr Leu Glu Asn Ile Lys Val Gly Asp Gln Ser Gly 
            580                 585                 590         
Ala Leu Lys Asp Ile Glu Ala Glu Val Lys His Ala Leu Asp Val Pro 
        595                 600                 605             
Trp Met Ala Gly Leu Glu Arg Ile Glu His Leu Arg Tyr Met Lys Ala 
    610                 615                 620                 
Phe Ala Phe Asp Asp Ile Trp Ile Gly Glu Thr Ser Ser Arg Ile Pro 
625                 630                 635                 640 
Phe Thr Gly Lys Asp Leu Phe Leu Ser Leu Ala Lys Gln Asp Phe Asn 
                645                 650                 655     
Ile Cys Gln Glu Ala Gln Gln Glu Asp Leu Lys Ala Leu Glu Lys Trp 
            660                 665                 670         
Ser Val Asp Ser Lys Leu Gly Asp Leu His Phe Ala Arg Gln Lys Leu 
        675                 680                 685             
Val Ala Cys Tyr Phe Ser Ala Ala Ser Thr Leu Phe Ser Pro Glu Met 
    690                 695                 700                 
Ser Thr Thr Arg Ile Val Trp Thr Lys Asn Ala Val Leu Thr Thr Leu 
705                 710                 715                 720 
Met Asp Asp Phe Tyr Asp Val Glu Gly Ser Ile Glu Asp Ile Gln Ser 
                725                 730                 735     
Phe Val Glu Ala Val Lys Arg Trp Asp Pro Ile Val Leu Cys Asn Cys 
            740                 745                 750         
Ser Ala Asn Val Lys Lys Leu Phe Ser Ala Ile Tyr Asn Thr Val Asn 
        755                 760                 765             
Asp Ile Ala Gln Asp Ile Trp Ile Phe Gln Gly Trp Asp Ile Ser Thr 
    770                 775                 780                 
Gln Leu Arg Glu Ile Trp Tyr Glu Leu Ala Ile Ser Met Met Lys Glu 
785                 790                 795                 800 
Ala Glu Trp Thr Lys Thr Gly Phe Ile Pro Ser Leu Glu Glu Tyr Met 
                805                 810                 815     
Glu Asn Gly Arg Thr Ser Ile Ala Leu Glu Pro Ile Ile Phe Thr Ser 
            820                 825                 830         
Leu Phe Phe Leu Gly Pro Lys Leu Ser Glu Gln Met Ile His Glu Tyr 
        835                 840                 845             
Lys Arg Leu Met Gln Leu Leu Asn Thr Cys Gly Arg Leu Leu Asn Asp 
    850                 855                 860                 
Ser Gln Ser Tyr Lys Arg Glu Ile Lys Gln Gly Lys Leu Asn Ser Leu 
865                 870                 875                 880 
Ser Leu Phe Val Lys Glu Tyr Pro Ala Thr Ser Ile Glu Asp Ala Thr 
                885                 890                 895     
Glu Trp Ile Arg Leu Thr Val Ser Glu Ser Arg Gln Asn Ile Leu Arg 
            900                 905                 910         
Asn Leu Leu Gln Pro Ser Glu Ile Pro Arg Glu Cys Lys Gln Ile Phe 
        915                 920                 925             
Trp Asn Met Val Lys Ile Ile Gln Leu Phe Tyr Leu His Ser Asp Glu 
    930                 935                 940                 
Phe Thr Ser Pro Thr Ala Met Leu Glu His Met Gln Ala Val Leu Phe 
945                 950                 955                 960 
Asn Pro Val Leu 
                

<210> 31
<211> 2823
<212> DNA
<213> Artificial Sequence


<220> 
<223> fusion

<400> 31
atgaagatcg aggaaggcaa gctcgtgatc tggatcaacg gcgacaaggg ctacaacggc      60

ctggccgagg tgggcaagaa gttcgagaag gacaccggca tcaaggtgac ggtggagcac     120

ccggacaagc tcgaggagaa gttcccgcag gtggcggcca cgggcgacgg cccggacatc     180

atcttctggg cccatgaccg cttcggcggc tacgcccagt cgggcctgct ggccgagatc     240

accccggaca aggcgttcca ggacaagctc tatcccttca cgtgggacgc cgtgcgctac     300

aacggcaagc tgatcgcgta tcccatcgcg gtggaggccc tgtcgctcat ctataacaag     360

gacctgctcc cgaacccgcc caagacctgg gaggagatcc ccgccctcga caaggagctg     420

aaggccaagg gcaagtcggc gctcatgttc aacctgcagg agccgtactt cacctggccc     480

ctgatcgcgg ccgacggcgg ctacgcgttc aagtatgaga acggcaagta tgacatcaag     540

gacgtgggcg tggacaacgc gggcgccaag gccggcctga ccttcctcgt ggacctgatc     600

aagaacaagc acatgaacgc cgacacggac tactcgatcg cggaggccgc gttcaacaag     660

ggcgagactg ccatgacgat caacggcccg tgggcgtggt cgaacatcga cacctcgaag     720

gtgaactatg gcgtgaccgt gctccccacg ttcaagggcc agccctcgaa gcccttcgtg     780

ggcgtgctgt cggcgggcat caacgccgcg tcgccgaaca aggagctcgc gaaggagttc     840

ctggagaact acctgctcac cgacgagggc ctggaggccg tgaacaagga caagcccctg     900

ggcgccgtgg ccctgaagtc gtatgaggaa gagctggtga aggacccgcg catcgcggcc     960

accatggaga acgcgcagaa gggcgagatc atgccgaaca tcccccagat gtcggccttc    1020

tggtatgcgg tgcgcaccgc cgtgatcaac gcggcctcgg gccgccagac cgtggacgag    1080

gccctcaagg acgcccagac cggcggaggt gctgccatgc tctcggtgga ggactcgtcg    1140

aacgtgctca tcaaggccga gaaggagaac cgcgagaaga agtcgttcgg ctcgatgtgc    1200

atcgacgaca acatcacccg catcaacatg ctcttcctcg agatcaagcg ccgctactcg    1260

tcgctctcgg cctacgacac cgtgcacggc gcctacccga tcaacctcat cctcggcctc    1320

tcgatggtga accacctcga gtcgctcggc atcgcccgcc acttcaagct cgagatcaag    1380

gaggtgctcg acgacgtgta ccgcttctgg atcgagaacg agatggtgaa gggcatgccg    1440

tcggcctcgg acatcatgac ctcgtcgatc tcgttcaaga tcctccgctg gaacggctac    1500

gacgtgtcgc cggacgtgtt cttctcgtac ctccgcgact cggacttcct cccgttcctc    1560

gagaactcgg gccaggccac tatggccctc ctcaacctct acaaggcctc gcagatgatg    1620

ttcccgggcg agcgcatcct cgaggaggcc aagtcgttct cgcagaacta cctcgagaac    1680

atcaaggtgg gcgaccagtc gggcgccctc aaggacatcg aggccgaggt gaagcacgcc    1740

ctcgacgtgc cgtggatggc cggcctcgag cgcatcgagc acctccgcta catgaaggcc    1800

ttcgccttcg acgacatctg gatcggcgag acgtcgtcgc gcatcccgtt caccggcaag    1860

gacctcttcc tctcgctcgc caagcaggac ttcaacatct gccaggaggc ccagcaggag    1920

gacctcaagg ccctcgagaa gtggtcggtg gactcgaagc tcggcgacct ccacttcgcc    1980

cgccagaagc tcgtggcctg ctacttctcg gccgcctcga ccctcttctc gccggagatg    2040

tcgaccaccc gcatcgtgtg gaccaagaac gccgtgctca ccaccctcat ggacgacttc    2100

tacgacgtgg agggctcgat cgaggacatc cagtcgttcg tggaggccgt gaagcgctgg    2160

gacccgatcg tgctctgcaa ctgctcggcc aacgtgaaga agctcttctc ggccatctac    2220

aacaccgtga acgacatcgc ccaggacatc tggatcttcc agggctggga catctcgacc    2280

cagctccgcg agatctggta cgagctcgcc atctcgatga tgaaggaggc cgagtggacc    2340

aagaccggct tcatcccgtc gctcgaggag tacatggaga acggccgcac ctcgatcgcc    2400

ctcgagccga tcatcttcac ctcgctcttc ttcctcggcc cgaagctctc ggagcagatg    2460

atccacgagt acaagcgcct catgcagctc ctcaacacct gcggcaggct cctcaacgac    2520

tcgcagtcgt acaagcgcga gatcaagcag ggcaagctca actcgctctc gctcttcgtg    2580

aaggagtacc cggccacctc gatcgaggac gccaccgagt ggatcaggct caccgtgtcg    2640

gagtcgcgcc agaacatcct ccgcaacctc ctccagccgt cggagatccc gcgcgagtgc    2700

aagcagatct tctggaacat ggtgaagatc atccagctct tctacctcca ctcggacgag    2760

ttcacctcgc cgaccgccat gctcgagcac atgcaggccg tgctcttcaa cccggtgctc    2820

taa                                                                  2823


<210> 32
<211> 2895
<212> DNA
<213> Artificial Sequence


<220> 
<223> fusion

<400> 32
atgaagatcg aggaaggcaa gctcgtgatc tggatcaacg gcgacaaggg ctacaacggc      60

ctggccgagg tgggcaagaa gttcgagaag gacaccggca tcaaggtgac ggtggagcac     120

ccggacaagc tcgaggagaa gttcccgcag gtggcggcca cgggcgacgg cccggacatc     180

atcttctggg cccatgaccg cttcggcggc tacgcccagt cgggcctgct ggccgagatc     240

accccggaca aggcgttcca ggacaagctc tatcccttca cgtgggacgc cgtgcgctac     300

aacggcaagc tgatcgcgta tcccatcgcg gtggaggccc tgtcgctcat ctataacaag     360

gacctgctcc cgaacccgcc caagacctgg gaggagatcc ccgccctcga caaggagctg     420

aaggccaagg gcaagtcggc gctcatgttc aacctgcagg agccgtactt cacctggccc     480

ctgatcgcgg ccgacggcgg ctacgcgttc aagtatgaga acggcaagta tgacatcaag     540

gacgtgggcg tggacaacgc gggcgccaag gccggcctga ccttcctcgt ggacctgatc     600

aagaacaagc acatgaacgc cgacacggac tactcgatcg cggaggccgc gttcaacaag     660

ggcgagactg ccatgacgat caacggcccg tgggcgtggt cgaacatcga cacctcgaag     720

gtgaactatg gcgtgaccgt gctccccacg ttcaagggcc agccctcgaa gcccttcgtg     780

ggcgtgctgt cggcgggcat caacgccgcg tcgccgaaca aggagctcgc gaaggagttc     840

ctggagaact acctgctcac cgacgagggc ctggaggccg tgaacaagga caagcccctg     900

ggcgccgtgg ccctgaagtc gtatgaggaa gagctggtga aggacccgcg catcgcggcc     960

accatggaga acgcgcagaa gggcgagatc atgccgaaca tcccccagat gtcggccttc    1020

tggtatgcgg tgcgcaccgc cgtgatcaac gcggcctcgg gccgccagac cgtggacgag    1080

gccctcaagg acgcccagac cggcggaggt gctgccatgg ccggcgcctc gaacttcaac    1140

ttcaacggcc gcaagaagtt caacccgcgc acccaccaga aggtgaagtc gctctcggtg    1200

gaggactcgt cgaacgtgct catcaaggcc gagaaggaga accgcgagaa gaagtcgttc    1260

ggctcgatgt gcatcgacga caacatcacc cgcatcaaca tgctcttcct cgagatcaag    1320

cgccgctact cgtcgctctc ggcctacgac accgtgcacg gcgcctaccc gatcaacctc    1380

atcctcggcc tctcgatggt gaaccacctc gagtcgctcg gcatcgcccg ccacttcaag    1440

ctcgagatca aggaggtgct cgacgacgtg taccgcttct ggatcgagaa cgagatggtg    1500

aagggcatgc cgtcggcctc ggacatcatg acctcgtcga tctcgttcaa gatcctccgc    1560

tggaacggct acgacgtgtc gccggacgtg ttcttctcgt acctccgcga ctcggacttc    1620

ctcccgttcc tcgagaactc gggccaggcc actatggccc tcctcaacct ctacaaggcc    1680

tcgcagatga tgttcccggg cgagcgcatc ctcgaggagg ccaagtcgtt ctcgcagaac    1740

tacctcgaga acatcaaggt gggcgaccag tcgggcgccc tcaaggacat cgaggccgag    1800

gtgaagcacg ccctcgacgt gccgtggatg gccggcctcg agcgcatcga gcacctccgc    1860

tacatgaagg ccttcgcctt cgacgacatc tggatcggcg agacgtcgtc gcgcatcccg    1920

ttcaccggca aggacctctt cctctcgctc gccaagcagg acttcaacat ctgccaggag    1980

gcccagcagg aggacctcaa ggccctcgag aagtggtcgg tggactcgaa gctcggcgac    2040

ctccacttcg cccgccagaa gctcgtggcc tgctacttct cggccgcctc gaccctcttc    2100

tcgccggaga tgtcgaccac ccgcatcgtg tggaccaaga acgccgtgct caccaccctc    2160

atggacgact tctacgacgt ggagggctcg atcgaggaca tccagtcgtt cgtggaggcc    2220

gtgaagcgct gggacccgat cgtgctctgc aactgctcgg ccaacgtgaa gaagctcttc    2280

tcggccatct acaacaccgt gaacgacatc gcccaggaca tctggatctt ccagggctgg    2340

gacatctcga cccagctccg cgagatctgg tacgagctcg ccatctcgat gatgaaggag    2400

gccgagtgga ccaagaccgg cttcatcccg tcgctcgagg agtacatgga gaacggccgc    2460

acctcgatcg ccctcgagcc gatcatcttc acctcgctct tcttcctcgg cccgaagctc    2520

tcggagcaga tgatccacga gtacaagcgc ctcatgcagc tcctcaacac ctgcggcagg    2580

ctcctcaacg actcgcagtc gtacaagcgc gagatcaagc agggcaagct caactcgctc    2640

tcgctcttcg tgaaggagta cccggccacc tcgatcgagg acgccaccga gtggatcagg    2700

ctcaccgtgt cggagtcgcg ccagaacatc ctccgcaacc tcctccagcc gtcggagatc    2760

ccgcgcgagt gcaagcagat cttctggaac atggtgaaga tcatccagct cttctacctc    2820

cactcggacg agttcacctc gccgaccgcc atgctcgagc acatgcaggc cgtgctcttc    2880

aacccggtgc tctaa                                                     2895


<210> 33
<211> 2895
<212> DNA
<213> Artificial Sequence


<220> 
<223> fusion

<400> 33
atgaagatcg aggaaggcaa gctcgtgatc tggatcaacg gcgacaaggg ctacaacggc      60

ctggccgagg tgggcaagaa gttcgagaag gacaccggca tcaaggtgac ggtggagcac     120

ccggacaagc tcgaggagaa gttcccgcag gtggcggcca cgggcgacgg cccggacatc     180

atcttctggg cccatgaccg cttcggcggc tacgcccagt cgggcctgct ggccgagatc     240

accccggaca aggcgttcca ggacaagctc tatcccttca cgtgggacgc cgtgcgctac     300

aacggcaagc tgatcgcgta tcccatcgcg gtggaggccc tgtcgctcat ctataacaag     360

gacctgctcc cgaacccgcc caagacctgg gaggagatcc ccgccctcga caaggagctg     420

aaggccaagg gcaagtcggc gctcatgttc aacctgcagg agccgtactt cacctggccc     480

ctgatcgcgg ccgacggcgg ctacgcgttc aagtatgaga acggcaagta tgacatcaag     540

gacgtgggcg tggacaacgc gggcgccaag gccggcctga ccttcctcgt ggacctgatc     600

aagaacaagc acatgaacgc cgacacggac tactcgatcg cggaggccgc gttcaacaag     660

ggcgagactg ccatgacgat caacggcccg tgggcgtggt cgaacatcga cacctcgaag     720

gtgaactatg gcgtgaccgt gctccccacg ttcaagggcc agccctcgaa gcccttcgtg     780

ggcgtgctgt cggcgggcat caacgccgcg tcgccgaaca aggagctcgc gaaggagttc     840

ctggagaact acctgctcac cgacgagggc ctggaggccg tgaacaagga caagcccctg     900

ggcgccgtgg ccctgaagtc gtatgaggaa gagctggtga aggacccgcg catcgcggcc     960

accatggaga acgcgcagaa gggcgagatc atgccgaaca tcccccagat gtcggccttc    1020

tggtatgcgg tgcgcaccgc cgtgatcaac gcggcctcgg gccgccagac cgtggacgag    1080

gccctcaagg acgcccagac cggcggaggt gctgccatgg ccggcgcctc gaacttcaac    1140

ttcaacggcc gcaagaagtt caacccgcgc acccaccaga aggtgaagtc gctctcgcgc    1200

cgcgactcgt cgaacgtgct catcaagtgg gagaaggaga accgcgagaa gaagtcgttc    1260

ggctcgatgt gcatcgacga caacatcacc cgcatcaaca tgctcttcct cgagatcaag    1320

cgccgctact cgtcgctctc ggcctacgac accgtgcacg gcgcctaccc gatcaacctc    1380

atcctcggcc tctcgatggt gaaccacctc gagtcgctcg gcatcgcccg ccacttcaag    1440

ctcgagatca aggaggtgct cgacgacgtg taccgcttct ggatcgagaa cgagatggtg    1500

aagggcatgc cgtcggcctc ggacatcatg acctcgtcga tctcgttcaa gatcctccgc    1560

tggaacggct acgacgtgtc gccggacgtg ttcttctcgt acctccgcga ctcggacttc    1620

ctcccgttcc tcgagaactc gggccaggcc actatggccc tcctcaacct ctacaaggcc    1680

tcgcagatga tgttcccggg cgagcgcatc ctcgaggagg ccaagtcgtt ctcgcagaac    1740

tacctcgaga acatcaaggt gggcgaccag tcgggcgccc tcaaggacat cgaggccgag    1800

gtgaagcacg ccctcgacgt gccgtggatg gccggcctcg agcgcatcga gcacctccgc    1860

tacatgaagg ccttcgcctt cgacgacatc tggatcggcg agacgtcgtc gcgcatcccg    1920

ttcaccggca aggacctctt cctctcgctc gccaagcagg acttcaacat ctgccaggag    1980

gcccagcagg aggacctcaa ggccctcgag aagtggtcgg tggactcgaa gctcggcgac    2040

ctccacttcg cccgccagaa gctcgtggcc tgctacttct cggccgcctc gaccctcttc    2100

tcgccggaga tgtcgaccac ccgcatcgtg tggaccaaga acgccgtgct caccaccctc    2160

atggacgact tctacgacgt ggagggctcg atcgaggaca tccagtcgtt cgtggaggcc    2220

gtgaagcgct gggacccgat cgtgctctgc aactgctcgg ccaacgtgaa gaagctcttc    2280

tcggccatct acaacaccgt gaacgacatc gcccaggaca tctggatctt ccagggctgg    2340

gacatctcga cccagctccg cgagatctgg tacgagctcg ccatctcgat gatgaaggag    2400

gccgagtgga ccaagaccgg cttcatcccg tcgctcgagg agtacatgga gaacggccgc    2460

acctcgatcg ccctcgagcc gatcatcttc acctcgctct tcttcctcgg cccgaagctc    2520

tcggagcaga tgatccacga gtacaagcgc ctcatgcagc tcctcaacac ctgcggcagg    2580

ctcctcaacg actcgcagtc gtacaagcgc gagatcaagc agggcaagct caactcgctc    2640

tcgctcttcg tgaaggagta cccggccacc tcgatcgagg acgccaccga gtggatcagg    2700

ctcaccgtgt cggagtcgcg ccagaacatc ctccgcaacc tcctccagcc gtcggagatc    2760

ccgcgcgagt gcaagcagat cttctggaac atggtgaaga tcatccagct cttctacctc    2820

cactcggacg agttcacctc gccgaccgcc atgctcgagc acatgcaggc cgtgctcttc    2880

aacccggtgc tctaa                                                     2895


<210> 34
<211> 631
<212> PRT
<213> Cupressus gigantea


<400> 34
Met Ala Ala Leu Ser Phe Ser Thr Ile Ser Thr Thr Ala Asn Tyr Ala 
1               5                   10                  15      
Ile Pro Lys Leu Pro Ser Ser Asn Leu Gln Gly Arg Ser Arg Asp Thr 
            20                  25                  30          
Lys Tyr His Val Leu Ile Arg Ser Ala Gly Ala Ser Asn Phe Asn Phe 
        35                  40                  45              
Asn Gly Arg Lys Lys Phe Asn Pro Arg Thr His Gln Lys Val Lys Ser 
    50                  55                  60                  
Leu Ser Val Glu Asp Ser Ser Asn Val Leu Ile Lys Ala Glu Lys Glu 
65                  70                  75                  80  
Asn Arg Glu Lys Lys Ser Phe Gly Ser Met Cys Ile Asp Asp Asn Ile 
                85                  90                  95      
Thr Arg Ile Asn Met Leu Phe Leu Glu Ile Lys Arg Arg Tyr Ser Ser 
            100                 105                 110         
Leu Ser Ala Tyr Asp Thr Val His Gly Ala Tyr Pro Ile Asn Leu Ile 
        115                 120                 125             
Leu Gly Leu Ser Met Val Asn His Leu Glu Ser Leu Gly Ile Ala Arg 
    130                 135                 140                 
His Phe Lys Leu Glu Ile Lys Glu Val Leu Asp Asp Val Tyr Arg Phe 
145                 150                 155                 160 
Trp Ile Glu Asn Glu Met Val Lys Gly Met Pro Ser Ala Ser Asp Ile 
                165                 170                 175     
Met Thr Ser Ser Ile Ser Phe Lys Ile Leu Arg Trp Asn Gly Tyr Asp 
            180                 185                 190         
Val Ser Pro Asp Val Phe Phe Ser Tyr Leu Arg Asp Ser Asp Phe Leu 
        195                 200                 205             
Pro Phe Leu Glu Asn Ser Gly Gln Ala Thr Met Ala Leu Leu Asn Leu 
    210                 215                 220                 
Tyr Lys Ala Ser Gln Met Met Phe Pro Gly Glu Arg Ile Leu Glu Glu 
225                 230                 235                 240 
Ala Lys Ser Phe Ser Gln Asn Tyr Leu Glu Asn Ile Lys Val Gly Asp 
                245                 250                 255     
Gln Ser Gly Ala Leu Lys Asp Ile Glu Ala Glu Val Lys His Ala Leu 
            260                 265                 270         
Asp Val Pro Trp Met Ala Gly Leu Glu Arg Ile Glu His Leu Arg Tyr 
        275                 280                 285             
Met Lys Ala Phe Ala Phe Asp Asp Ile Trp Ile Gly Glu Thr Ser Ser 
    290                 295                 300                 
Arg Ile Pro Phe Thr Gly Lys Asp Leu Phe Leu Ser Leu Ala Lys Gln 
305                 310                 315                 320 
Asp Phe Asn Ile Cys Gln Glu Ala Gln Gln Glu Asp Leu Lys Ala Leu 
                325                 330                 335     
Glu Lys Trp Ser Val Asp Ser Lys Leu Gly Asp Leu His Phe Ala Arg 
            340                 345                 350         
Gln Lys Leu Val Ala Cys Tyr Phe Ser Ala Ala Ser Thr Leu Phe Ser 
        355                 360                 365             
Pro Glu Met Ser Thr Thr Arg Ile Val Trp Thr Lys Asn Ala Val Leu 
    370                 375                 380                 
Thr Thr Leu Met Asp Asp Phe Tyr Asp Val Glu Gly Ser Ile Glu Asp 
385                 390                 395                 400 
Ile Gln Ser Phe Val Glu Ala Val Lys Arg Trp Asp Pro Ile Val Leu 
                405                 410                 415     
Cys Asn Cys Ser Ala Asn Val Lys Lys Leu Phe Ser Ala Ile Tyr Asn 
            420                 425                 430         
Thr Val Asn Asp Ile Ala Gln Asp Ile Trp Ile Phe Gln Gly Trp Asp 
        435                 440                 445             
Ile Ser Thr Gln Leu Arg Glu Ile Trp Tyr Glu Leu Ala Ile Ser Met 
    450                 455                 460                 
Met Lys Glu Ala Glu Trp Thr Lys Thr Gly Phe Ile Pro Ser Leu Glu 
465                 470                 475                 480 
Glu Tyr Met Glu Asn Gly Arg Thr Ser Ile Ala Leu Glu Pro Ile Ile 
                485                 490                 495     
Phe Thr Ser Leu Phe Phe Leu Gly Pro Lys Leu Ser Glu Gln Met Ile 
            500                 505                 510         
His Glu Tyr Lys Arg Leu Met Gln Leu Leu Asn Thr Cys Gly Arg Leu 
        515                 520                 525             
Leu Asn Asp Ser Gln Ser Tyr Lys Arg Glu Ile Lys Gln Gly Lys Leu 
    530                 535                 540                 
Thr Ser Leu Ser Leu Phe Val Lys Glu Tyr Pro Ala His Leu Ile Glu 
545                 550                 555                 560 
Asp Ala Thr Glu Trp Ile Arg Leu Thr Val Ser Glu Ser Arg Gln Asn 
                565                 570                 575     
Ile Leu Arg Asn Leu Leu Gln Pro Ser Glu Ile Pro Arg Glu Cys Lys 
            580                 585                 590         
Gln Ile Phe Trp Asn Met Val Lys Ile Ile Gln Leu Phe Tyr Leu His 
        595                 600                 605             
Ser Asp Glu Phe Thr Ser Pro Thr Ala Met Leu Glu His Met Gln Ala 
    610                 615                 620                 
Val Leu Phe Asn Pro Val Leu 
625                 630     

<210> 35
<211> 1896
<212> DNA
<213> Cupressus gigantea


<400> 35
atggcagcac ttagtttttc taccatctcc accactgcca actatgcaat tcctaagctg      60

ccatcttcaa atcttcaagg gcggtccaga gatacaaaat accatgtctt gataagatct     120

gcaggggcct ctaatttcaa cttcaatgga agaaagaagt tcaatccaag aacacatcag     180

aaagtcaaat ctttgagtgt tgaagattcc tccaatgtac ttattaaggc tgagaaagag     240

aacagagaga aaaaatcatt tggttcgatg tgcatagacg ataatattac aaggataaat     300

atgttgttct tggaaattaa gagaagatat tcatctcttt ctgcttatga tacagtgcac     360

ggtgcttatc ctatcaattt gattcttggc ctctcaatgg taaatcattt ggagagcttg     420

ggtatagcaa gacatttcaa acttgagata aaagaggttc tagatgatgt ctatagattt     480

tggatagaga atgaaatggt taaaggaatg ccatcagcat cagacataat gaccagttct     540

atcagtttca agatcttgcg gtggaatgga tatgacgtgt ctccagatgt ctttttcagt     600

tacctgaggg atagtgactt cctaccattt ctagaaaata gtggccaagc tactatggca     660

ttgctgaatt tatacaaggc atctcagatg atgttcccag gggaaagaat tcttgaagaa     720

gcaaaatcgt tctcccaaaa ttatcttgaa aatatcaagg tgggcgatca aagtggagct     780

ctcaaagata ttgaagcaga ggttaagcat gcactggatg ttccttggat ggctggtttg     840

gagagaatag aacatctgcg atacatgaaa gcatttgctt ttgatgatat ttggattgga     900

gagacctctt ctaggatccc atttacagga aaggatttat ttttatcttt agccaaacaa     960

gacttcaata tctgccaaga agctcaacaa gaggatttga aagcgttgga aaaatggagt    1020

gtagactcta aacttggtga cctacacttt gctagacaaa agcttgtagc ctgctatttc    1080

tctgccgcct caacactttt tagccctgaa atgtctacta ctcggattgt gtggactaaa    1140

aatgctgttc tcactactct aatggatgac ttttatgatg tggagggttc cattgaagat    1200

attcaatcct ttgttgaagc agttaagaga tgggacccaa tagttttatg taattgttca    1260

gctaatgtga aaaaattatt ctctgctatt tataacactg tgaatgatat tgctcaagat    1320

atatggattt tccagggctg ggacattagc actcagttaa gagaaatttg gtacgaactg    1380

gcaatctcaa tgatgaagga ggctgaatgg accaaaactg gatttatacc atcgctggaa    1440

gaatacatgg aaaatgggag aacgtcaatt gccttggaac caattatttt tacatcacta    1500

ttttttcttg gccctaagct ttccgagcaa atgatccacg agtataagag acttatgcaa    1560

ctcctgaata cttgtgggcg ccttttgaat gacagtcaga gctacaagag ggagataaag    1620

caaggaaagc tcacctcttt atcattgttc gtgaaagaat atcccgcaca tcttattgag    1680

gatgctactg agtggattag actcactgta agtgaaagca gacaaaatat actcagaaat    1740

ttattgcaac caagtgagat ccctcgtgaa tgcaagcaga tattttggaa tatggtcaaa    1800

attatccaac tattctacct ccacagtgat gaattcacat ctcctactgc aatgcttgaa    1860

catatgcaag cagttctttt taatcctgtt ttataa                              1896


<210> 36
<211> 1650
<212> DNA
<213> Artificial Sequence


<220> 
<223> truncated

<400> 36
atggagaaaa aatcatttgg ttcgatgtgc atagatgatg atattacaaa gataaaaatg      60

ttgttctcgg aaattaaaag aagatattca tctctttctg cttatgatac agtgcacggt     120

gcttatccta tcaatttgat tcttggcctc tcaatggtaa accacttgga gagcttgggt     180

atagcaagac atttcaaact tgagataaaa gaggttctag atgatgtcta tagattttgg     240

atagagaatg aaatggttga aggaatgcca tcagcatcag acataatgac cagttctatc     300

agtttcagga tcttgcggtg gaatggatat gacgtgtctc cagatgtctt tttcagttac     360

ctgagggata gtgacttcct actattttta gaaaatagtg accaagctac tatagcattg     420

ctgaatttat acaaggcatc tcagatgatg ttcccaggcg aaagaattct tgaagaagca     480

aaattgttct cccaaaatta tcttgaaaat atcaagatgg gcaatcaaag tggagctctc     540

aaagacattg aagcagaggt taagcatgca ctggatgtcc cttggatggc taatttggag     600

agaatagaac atctgcgata catgaaagca tttgcttttg acaatatttg gattggagag     660

acctcttcta ggatcccatt tacaggaaag gatttatttt tatcttttgc caaacaagac     720

ttcaatatct gccaagcagc tcaacaagag gatttgaagg cgttggaaaa atggagtgta     780

gactctaaac ttggtgacct acactttgct agacaaaagc ttgtagcctg ctatttctct     840

gccgcctcaa tactttttag ccctgaaatg tctgctactc ggattgtgtg gactaaaaat     900

gctgttctca ttacactaat ggatgacttt tatgatgtgg agggttccat ygaagatatt     960

caatcctttg ttgaagcggt taagagatgg gacccaatag ttttatgtaa ttgttcagct    1020

aatgttaaaa ttttattctc tgctatttat aacactgtga atgatattgc tcaagatata    1080

tggattttcc agggctggga cattagcact cagttaagag aaatttggta cgaactggca    1140

atctcaatga tgaaggaggc tgaatggacc aaaactggat ttataccatc cttggaagaa    1200

tacatggaaa atgggagaac atcaattgcc ttggaaccaa ttatttttac atcactattt    1260

tttattggcc ctaagctttc cgagcaaatg atccaccatc acgagtataa gaggcttttg    1320

caactcatga atacttgtgg gcgccttttg aatgacattc agagcgacaa gagggagatg    1380

aagcaaggaa agctcacctc tgtatcattg ttcgtgaaag aatacccaat tgaggatgct    1440

actaagtgga ttagactcac tgtaagtgaa aacacacaaa atatactcaa aaaaatattg    1500

caaccaagtg agatccctcg tgaatgcaag cagatatttt ggaatatggt caaaattatc    1560

caactattct gcctccacag tgatgaattc acatctccta ccacaatgct tgaacatatg    1620

aaggcagttc ttttttatcc tgttttataa                                     1650


<210> 37
<211> 1653
<212> DNA
<213> Artificial Sequence


<220> 
<223> truncated

<400> 37
atggagaaaa aatcatttgg ttcgatgtgc atagacgata atattacaag gataaatatg      60

ttgttcttgg aaattaagag aagatattca tctctttctg cttatgatac agtgcacggt     120

gcttatccta tcaatttgat tcttggcctc tcaatggtaa atcatttgga gagcttgggt     180

atagcaagac atttcaaact tgagataaaa gaggttctag atgatgtcta tagattttgg     240

atagagaatg aaatggttaa aggaatgcca tcagcatcag acataatgac cagttctatc     300

agtttcaaga tcttgcggtg gaatggatat gacgtgtctc cagatgtctt tttcagttac     360

ctgagggata gtgacttcct accatttcta gaaaatagtg gccaagctac tatggcattg     420

ctgaatttat acaaggcatc tcagatgatg ttcccagggg aaagaattct tgaagaagca     480

aaatcgttct cccaaaatta tcttgaaaat atcaaggtgg gcgatcaaag tggagctctc     540

aaagatattg aagcagaggt taagcatgca ctggatgttc cttggatggc tggtttggag     600

agaatagaac atctgcgata catgaaagca tttgcttttg atgatatttg gattggagag     660

acctcttcta ggatcccatt tacaggaaag gatttatttt tatctttagc caaacaagac     720

ttcaatatct gccaagaagc tcaacaagag gatttgaaag cgttggaaaa atggagtgta     780

gactctaaac ttggtgacct acactttgct agacaaaagc ttgtagcctg ctatttctct     840

gccgcctcaa cactttttag ccctgaaatg tctactactc ggattgtgtg gactaaaaat     900

gctgttctca ctactctaat ggatgacttt tatgatgtgg agggttccat tgaagatatt     960

caatcctttg ttgaagcagt taagagatgg gacccaatag ttttatgtaa ttgttcagct    1020

aatgtgaaaa aattattctc tgctatttat aacactgtga atgatattgc tcaagatata    1080

tggattttcc agggctggga cattagcact cagttaagag aaatttggta cgaactggca    1140

atctcaatga tgaaggaggc tgaatggacc aaaactggat ttataccatc gctggaagaa    1200

tacatggaaa atgggagaac gtcaattgcc ttggaaccaa ttatttttac atcactattt    1260

tttcttggcc ctaagctttc cgagcaaatg atccacgagt ataagagact tatgcaactc    1320

ctgaatactt gtgggcgcct tttgaatgac agtcagagct acaagaggga gataaagcaa    1380

ggaaagctca actctttatc attgttcgtg aaagaatatc ccgcaacatc tattgaggat    1440

gctactgagt ggattagact cactgtaagt gaaagcagac aaaatatact cagaaattta    1500

ttgcaaccaa gtgagatccc tcgtgaatgc aagcagatat tttggaatat ggtcaaaatt    1560

atccaactat tctacctcca cagtgatgaa ttcacatctc ctactgcaat gcttgaacat    1620

atgcaagcag ttctttttaa tcctgtttta taa                                 1653


<210> 38
<211> 1653
<212> DNA
<213> Artificial Sequence


<220> 
<223> truncated

<400> 38
atggagaaaa aatcatttgg ttcgatgtgc atagacgata atattacaag gataaatatg      60

ttgttcttgg aaattaagag aagatattca tctctttctg cttatgatac agtgcacggt     120

gcttatccta tcaatttgat tcttggcctc tcaatggtaa atcatttgga gagcttgggt     180

atagcaagac atttcaaact tgagataaaa gaggttctag atgatgtcta tagattttgg     240

atagagaatg aaatggttaa aggaatgcca tcagcatcag acataatgac cagttctatc     300

agtttcaaga tcttgcggtg gaatggatat gacgtgtctc cagatgtctt tttcagttac     360

ctgagggata gtgacttcct accatttcta gaaaatagtg gccaagctac tatggcattg     420

ctgaatttat acaaggcatc tcagatgatg ttcccagggg aaagaattct tgaagaagca     480

aaatcgttct cccaaaatta tcttgaaaat atcaaggtgg gcgatcaaag tggagctctc     540

aaagatattg aagcagaggt taagcatgca ctggatgttc cttggatggc tggtttggag     600

agaatagaac atctgcgata catgaaagca tttgcttttg atgatatttg gattggagag     660

acctcttcta ggatcccatt tacaggaaag gatttatttt tatctttagc caaacaagac     720

ttcaatatct gccaagaagc tcaacaagag gatttgaaag cgttggaaaa atggagtgta     780

gactctaaac ttggtgacct acactttgct agacaaaagc ttgtagcctg ctatttctct     840

gccgcctcaa cactttttag ccctgaaatg tctactactc ggattgtgtg gactaaaaat     900

gctgttctca ctactctaat ggatgacttt tatgatgtgg agggttccat tgaagatatt     960

caatcctttg ttgaagcagt taagagatgg gacccaatag ttttatgtaa ttgttcagct    1020

aatgtgaaaa aattattctc tgctatttat aacactgtga atgatattgc tcaagatata    1080

tggattttcc agggctggga cattagcact cagttaagag aaatttggta cgaactggca    1140

atctcaatga tgaaggaggc tgaatggacc aaaactggat ttataccatc gctggaagaa    1200

tacatggaaa atgggagaac gtcaattgcc ttggaaccaa ttatttttac atcactattt    1260

tttcttggcc ctaagctttc cgagcaaatg atccacgagt ataagagact tatgcaactc    1320

ctgaatactt gtgggcgcct tttgaatgac agtcagagct acaagaggga gataaagcaa    1380

ggaaagctca cctctttatc attgttcgtg aaagaatatc ccgcacatct tattgaggat    1440

gctactgagt ggattagact cactgtaagt gaaagcagac aaaatatact cagaaattta    1500

ttgcaaccaa gtgagatccc tcgtgaatgc aagcagatat tttggaatat ggtcaaaatt    1560

atccaactat tctacctcca cagtgatgaa ttcacatctc ctactgcaat gcttgaacat    1620

atgcaagcag ttctttttaa tcctgtttta taa                                 1653


<210> 39
<211> 1550
<212> DNA
<213> Artificial Sequence


<220> 
<223> truncated

<400> 39
atggagaaga agtcgttcgg ctcgatgtgc atcgacgacg acatcaccaa gatcaagatg      60

ctcttctcgg agatcaagcg ccgctactcg tcgctctcgg cctacgacac cgtgcacggc     120

gcctacccga tcaacctcat cctcggcctc tcgatggtga accacctcga gtcgctcggc     180

atcgcccgcc acttcaagct cgagatcaag gaggtgctcg acgacgtgta ccgcttctgg     240

atcgagaacg agatggtgga gggcatgccg tcggcctcgg acatcatgac ctcgtcgatc     300

tcgttccgca tcctccgctg gaacggctac gacgtgtcgc cggacgtgtt cttctcgtac     360

ctccgcgact cggacttcct cctcttcctc gagaactcgg accaggccac catcgccctc     420

ctcaacctct acaaggcctc gcagatgatg ttcccgggcg agcgcatcct cgaggaggcc     480

aagctcttct cgcagaacta cctcgagaac atcaagatgg gcaaccagtc gggcgccctc     540

aaggacatcg aggccgaggt gaagcacgcc ctcgacgtgc cgtggatggc caacctcgag     600

cgcatcgagc acctccgcta catgaaggcc ttcgccttcg acaacatctg gatcggcgag     660

acgtcgtcgc gcatcccgtt caccggcaag gacctcttcc tctcgttcgc caagcaggac     720

ttcaacatct gccaggccgc ccagcaggag gacctcaagg ccctcgagaa gtggtcggtg     780

gactcgaagc tcggcgacct ccacttcgcc cgccagaagc tcgtggcctg ctacttctcg     840

gccgcctcga tcctcttctc gccggagatg tcggccaccc gcatcgtgtg gaccaagaac     900

gccgtgctca tcaccctcat ggacgacttc tacgacgtgg agggctcgat cgaggacatc     960

cagtcgttcg tggaggccgt gaagcgctgg gacccgatcg tgctctgcaa ctgctcggcc    1020

aacgtgaaga tcctcttctc ggccatctac aacaccgtga acgacatcgc ccaggacatc    1080

tggatcttcc agggctggga catctcgacc cagctccgcg agatctggta cgagctcgcc    1140

atctcgatga tgaaggaggc cgagtggacc aagaccggct tcatcccgtc gctcgaggag    1200

tacatggaga acggccgcac ctcgatcgcc ctcgagccga tcatcttcac ctcgctcttc    1260

ttcatcggcc cgaagctctc ggagcagatg atccaccacc acgagtacaa gcgcctcctc    1320

cagctcatga acacctgcgg ccgcctcctc aacgacatcc agtcggacaa gcgcgagatg    1380

aagcagggca agctcacctc ggtgtcgctc ttcgtgaagg agtacccgat cgaggacgcc    1440

accaagtgga tccgcctcac cgtgtcggag aacacccaga acatcctcaa gaagatcctc    1500

cagccgtcgg agatcccgcg cgagtgcaag cagatcttct ggaacatggt               1550


<210> 40
<211> 516
<212> PRT
<213> Artificial Sequence


<220> 
<223> truncated

<400> 40
Met Glu Lys Lys Ser Phe Gly Ser Met Cys Ile Asp Asp Asp Ile Thr 
1               5                   10                  15      
Lys Ile Lys Met Leu Phe Ser Glu Ile Lys Arg Arg Tyr Ser Ser Leu 
            20                  25                  30          
Ser Ala Tyr Asp Thr Val His Gly Ala Tyr Pro Ile Asn Leu Ile Leu 
        35                  40                  45              
Gly Leu Ser Met Val Asn His Leu Glu Ser Leu Gly Ile Ala Arg His 
    50                  55                  60                  
Phe Lys Leu Glu Ile Lys Glu Val Leu Asp Asp Val Tyr Arg Phe Trp 
65                  70                  75                  80  
Ile Glu Asn Glu Met Val Glu Gly Met Pro Ser Ala Ser Asp Ile Met 
                85                  90                  95      
Thr Ser Ser Ile Ser Phe Arg Ile Leu Arg Trp Asn Gly Tyr Asp Val 
            100                 105                 110         
Ser Pro Asp Val Phe Phe Ser Tyr Leu Arg Asp Ser Asp Phe Leu Leu 
        115                 120                 125             
Phe Leu Glu Asn Ser Asp Gln Ala Thr Ile Ala Leu Leu Asn Leu Tyr 
    130                 135                 140                 
Lys Ala Ser Gln Met Met Phe Pro Gly Glu Arg Ile Leu Glu Glu Ala 
145                 150                 155                 160 
Lys Leu Phe Ser Gln Asn Tyr Leu Glu Asn Ile Lys Met Gly Asn Gln 
                165                 170                 175     
Ser Gly Ala Leu Lys Asp Ile Glu Ala Glu Val Lys His Ala Leu Asp 
            180                 185                 190         
Val Pro Trp Met Ala Asn Leu Glu Arg Ile Glu His Leu Arg Tyr Met 
        195                 200                 205             
Lys Ala Phe Ala Phe Asp Asn Ile Trp Ile Gly Glu Thr Ser Ser Arg 
    210                 215                 220                 
Ile Pro Phe Thr Gly Lys Asp Leu Phe Leu Ser Phe Ala Lys Gln Asp 
225                 230                 235                 240 
Phe Asn Ile Cys Gln Ala Ala Gln Gln Glu Asp Leu Lys Ala Leu Glu 
                245                 250                 255     
Lys Trp Ser Val Asp Ser Lys Leu Gly Asp Leu His Phe Ala Arg Gln 
            260                 265                 270         
Lys Leu Val Ala Cys Tyr Phe Ser Ala Ala Ser Ile Leu Phe Ser Pro 
        275                 280                 285             
Glu Met Ser Ala Thr Arg Ile Val Trp Thr Lys Asn Ala Val Leu Ile 
    290                 295                 300                 
Thr Leu Met Asp Asp Phe Tyr Asp Val Glu Gly Ser Ile Glu Asp Ile 
305                 310                 315                 320 
Gln Ser Phe Val Glu Ala Val Lys Arg Trp Asp Pro Ile Val Leu Cys 
                325                 330                 335     
Asn Cys Ser Ala Asn Val Lys Ile Leu Phe Ser Ala Ile Tyr Asn Thr 
            340                 345                 350         
Val Asn Asp Ile Ala Gln Asp Ile Trp Ile Phe Gln Gly Trp Asp Ile 
        355                 360                 365             
Ser Thr Gln Leu Arg Glu Ile Trp Tyr Glu Leu Ala Ile Ser Met Met 
    370                 375                 380                 
Lys Glu Ala Glu Trp Thr Lys Thr Gly Phe Ile Pro Ser Leu Glu Glu 
385                 390                 395                 400 
Tyr Met Glu Asn Gly Arg Thr Ser Ile Ala Leu Glu Pro Ile Ile Phe 
                405                 410                 415     
Thr Ser Leu Phe Phe Ile Gly Pro Lys Leu Ser Glu Gln Met Ile His 
            420                 425                 430         
His His Glu Tyr Lys Arg Leu Leu Gln Leu Met Asn Thr Cys Gly Arg 
        435                 440                 445             
Leu Leu Asn Asp Ile Gln Ser Asp Lys Arg Glu Met Lys Gln Gly Lys 
    450                 455                 460                 
Leu Thr Ser Val Ser Leu Phe Val Lys Glu Tyr Pro Ile Glu Asp Ala 
465                 470                 475                 480 
Thr Lys Trp Ile Arg Leu Thr Val Ser Glu Asn Thr Gln Asn Ile Leu 
                485                 490                 495     
Lys Lys Ile Leu Gln Pro Ser Glu Ile Pro Arg Glu Cys Lys Gln Ile 
            500                 505                 510         
Phe Trp Asn Met 
        515     

<210> 41
<211> 631
<212> PRT
<213> Artificial Sequence


<220> 
<223> variant 1

<400> 41
Met Ala Ala Leu Ser Phe Ser Thr Ile Ser Thr Thr Ala Asn Tyr Ala 
1               5                   10                  15      
Ile Pro Arg Ile Pro Ser Ser Asn Leu Gln Gly Arg Ser Arg Asp Thr 
            20                  25                  30          
Lys Tyr His Val Leu Ile Arg Ser Ala Gly Gly Ser Asn Phe Asn Phe 
        35                  40                  45              
Asn Gly Arg Lys Lys Phe Asn Pro Arg Thr His Gln Lys Ile Lys Ser 
    50                  55                  60                  
Leu Ser Val Glu Asp Ser Ser Asn Val Leu Ile Lys Ala Glu Lys Glu 
65                  70                  75                  80  
Gln Arg Glu Lys Lys Ser Phe Gly Ser Met Cys Ile Asp Asp Asn Ile 
                85                  90                  95      
Thr Arg Ile Gln Met Leu Phe Leu Glu Ile Lys Arg Arg Tyr Ser Ser 
            100                 105                 110         
Leu Ser Ala Tyr Asp Thr Val His Gly Ala Tyr Pro Ile Asn Leu Ile 
        115                 120                 125             
Ile Gly Leu Ser Met Val Asn His Leu Glu Ser Leu Gly Ile Gly Arg 
    130                 135                 140                 
His Phe Lys Leu Glu Ile Lys Glu Val Leu Asp Asp Val Tyr Arg Phe 
145                 150                 155                 160 
Trp Ile Glu Asn Glu Met Val Lys Gly Met Pro Ser Ala Ser Asp Ile 
                165                 170                 175     
Met Thr Ser Ser Ile Ser Phe Lys Ile Leu Arg Trp Asn Gly Tyr Asp 
            180                 185                 190         
Val Ser Pro Asp Val Phe Phe Ser Tyr Leu Lys Asp Ser Asp Phe Leu 
        195                 200                 205             
Pro Phe Leu Glu Asn Ser Gly Gln Ala Thr Met Ala Leu Leu Asn Leu 
    210                 215                 220                 
Tyr Lys Ala Ser Gln Met Met Phe Pro Gly Glu Arg Ile Leu Glu Glu 
225                 230                 235                 240 
Ala Lys Ser Phe Ser Gln Asn Tyr Leu Glu Asn Ile Lys Val Gly Asp 
                245                 250                 255     
Gln Ser Gly Ala Leu Lys Asp Ile Glu Ala Asp Val Lys His Ala Leu 
            260                 265                 270         
Asp Val Pro Trp Met Ala Ala Leu Glu Arg Ile Glu His Leu Arg Tyr 
        275                 280                 285             
Met Lys Ala Phe Ala Phe Asp Asp Ile Trp Leu Gly Glu Thr Ser Ser 
    290                 295                 300                 
Arg Ile Pro Trp Thr Gly Lys Asp Leu Phe Leu Ser Leu Ala Lys Gln 
305                 310                 315                 320 
Asp Phe Asn Ile Cys Gln Glu Ala Gln Gln Glu Asp Leu Arg Ala Leu 
                325                 330                 335     
Glu Lys Trp Ser Val Asp Ser Lys Leu Gly Glu Leu His Phe Ala Arg 
            340                 345                 350         
Gln Lys Leu Val Ala Cys Tyr Phe Ser Ala Ala Ser Ser Leu Phe Ser 
        355                 360                 365             
Pro Glu Met Ser Thr Thr Arg Ile Val Trp Thr Lys Asn Ala Val Leu 
    370                 375                 380                 
Thr Thr Leu Met Asp Asp Phe Tyr Asp Val Glu Gly Ser Leu Glu Asp 
385                 390                 395                 400 
Ile Gln Ser Phe Val Glu Ala Val Arg Arg Trp Asp Pro Ile Val Leu 
                405                 410                 415     
Cys Asn Cys Ser Ala Gln Val Lys Lys Leu Phe Ser Ala Ile Tyr Asn 
            420                 425                 430         
Thr Val Asn Asp Ile Ala Gln Asp Val Trp Ile Phe Gln Gly Phe Asp 
        435                 440                 445             
Ile Ser Thr Gln Leu Arg Glu Ile Trp Phe Glu Leu Ala Ile Ser Met 
    450                 455                 460                 
Met Lys Glu Ala Glu Trp Thr Lys Thr Gly Phe Ile Pro Thr Leu Glu 
465                 470                 475                 480 
Glu Tyr Met Glu Asn Gly Arg Thr Ser Ile Ala Leu Glu Pro Ile Ile 
                485                 490                 495     
Phe Thr Ser Leu Phe Phe Leu Gly Pro Lys Leu Ser Glu Asn Met Ile 
            500                 505                 510         
His Glu Tyr Lys Arg Leu Met Gln Leu Leu Asn Thr Cys Gly Arg Leu 
        515                 520                 525             
Leu Asn Asp Ser Gln Ser Tyr Lys Arg Glu Val Lys Gln Gly Lys Leu 
    530                 535                 540                 
Asn Ser Leu Ser Leu Phe Val Lys Glu Tyr Pro Ala Ser Ser Ile Glu 
545                 550                 555                 560 
Asp Ala Thr Glu Trp Ile Arg Leu Thr Val Thr Glu Ser Arg Gln Asn 
                565                 570                 575     
Ile Leu Arg Asn Leu Leu Gln Pro Ser Glu Ile Pro Arg Glu Cys Lys 
            580                 585                 590         
Gln Ile Phe Trp Asn Lys Val Lys Leu Ile Gln Leu Phe Tyr Leu His 
        595                 600                 605             
Ser Asp Glu Phe Thr Ser Pro Thr Ala Met Leu Glu His Met Gln Ala 
    610                 615                 620                 
Val Val Tyr Asn Pro Leu Leu 
625                 630     

<210> 42
<211> 631
<212> PRT
<213> Artificial Sequence


<220> 
<223> variant 2

<400> 42
Met Gly Gly Leu Ser Phe Ser Thr Ile Ser Thr Thr Ala Asn Trp Ala 
1               5                   10                  15      
Leu Pro Lys Leu Pro Ser Ser Asn Leu Gln Gly Met Ser Arg Asp Thr 
            20                  25                  30          
Lys Tyr His Val Leu Ile Arg Ser Ala Ala Ala Ser Asn Phe Asn Phe 
        35                  40                  45              
Asn Gly Arg Arg Lys Phe Asn Pro Arg Thr His Gln Lys Ile Lys Ser 
    50                  55                  60                  
Leu Ser Val Glu Asp Thr Ser Asn Val Leu Ile Lys Ala Glu Lys Glu 
65                  70                  75                  80  
Asn Arg Asp Lys Lys Ser Phe Gly Ser Met Cys Ile Asp Asp Asn Ile 
                85                  90                  95      
Thr Arg Leu Asn Met Leu Phe Leu Glu Ile Lys Lys Lys Tyr Ser Ser 
            100                 105                 110         
Leu Ser Ala Phe Asp Thr Val His Gly Ala Tyr Pro Ile Asn Val Ile 
        115                 120                 125             
Leu Gly Leu Ser Met Val Asn His Leu Glu Ser Leu Gly Ile Ala Met 
    130                 135                 140                 
His Phe Met Leu Glu Ile Lys Glu Ile Leu Asp Asp Val Tyr Arg Phe 
145                 150                 155                 160 
Trp Ile Glu Asn Glu Met Leu Lys Gly Lys Pro Ser Ala Ser Asp Ile 
                165                 170                 175     
Met Thr Ser Ser Ile Ser Phe Lys Ile Leu Arg Trp Asn Gly Tyr Asp 
            180                 185                 190         
Val Ser Pro Asp Val Phe Phe Ser Tyr Leu Met Asp Ser Asp Phe Leu 
        195                 200                 205             
Pro Tyr Val Glu Asn Ser Ala Gln Ala Ser Met Ala Leu Leu Asn Leu 
    210                 215                 220                 
Tyr Lys Ala Ser Gln Met Met Phe Pro Gly Glu Arg Ile Leu Glu Glu 
225                 230                 235                 240 
Ala Lys Ser Phe Ser Gln Asn Tyr Leu Asp Asn Ile Lys Ile Gly Asp 
                245                 250                 255     
Gln Ser Ala Ala Leu Lys Asp Ile Glu Ala Glu Val Lys His Ala Leu 
            260                 265                 270         
Asp Val Pro Trp Met Ala Gly Leu Glu Arg Ile Glu His Leu Arg Tyr 
        275                 280                 285             
Met Lys Ala Phe Ala Phe Asp Asp Ile Tyr Ile Gly Glu Thr Ser Ser 
    290                 295                 300                 
Met Ile Pro Phe Thr Gly Arg Asp Leu Phe Leu Ser Leu Ala Lys Gln 
305                 310                 315                 320 
Asp Phe Asn Ile Cys Gln Glu Ala Gln Gln Glu Asp Leu Arg Ala Leu 
                325                 330                 335     
Glu Lys Trp Ser Val Asp Ser Lys Leu Gly Asp Leu His Phe Ala Arg 
            340                 345                 350         
Gln Lys Leu Val Gly Cys Tyr Phe Thr Ala Ala Ser Thr Leu Phe Ser 
        355                 360                 365             
Pro Asp Met Ser Thr Thr Arg Ile Leu Phe Thr Lys Asn Ala Val Leu 
    370                 375                 380                 
Thr Thr Leu Met Asp Asp Phe Tyr Asp Val Glu Gly Ser Ile Glu Asp 
385                 390                 395                 400 
Ile Gln Ser Phe Val Glu Ala Val Lys Arg Trp Asp Pro Ile Val Leu 
                405                 410                 415     
Cys Asn Cys Ser Ala Gln Val Lys Lys Leu Phe Ser Ala Ile Tyr Asn 
            420                 425                 430         
Thr Ile Asn Asp Ile Ala Gln Asp Val Tyr Ile Phe Gln Gly Trp Asp 
        435                 440                 445             
Ile Ser Thr Gln Leu Arg Glu Ile Tyr Tyr Glu Leu Ala Val Ser Met 
    450                 455                 460                 
Met Lys Glu Ala Glu Trp Thr Lys Thr Ala Tyr Ile Pro Ser Leu Glu 
465                 470                 475                 480 
Glu Tyr Met Glu Asn Gly Arg Thr Ser Ile Ala Leu Glu Pro Ile Ile 
                485                 490                 495     
Phe Thr Ser Leu Phe Trp Leu Gly Pro Lys Leu Ser Glu Gln Met Ile 
            500                 505                 510         
His Glu Phe Lys Arg Leu Met Gln Leu Leu Asn Thr Cys Gly Arg Leu 
        515                 520                 525             
Leu Asn Asp Ser Gln Ser Trp Lys Arg Glu Ile Lys Asn Gly Lys Leu 
    530                 535                 540                 
Gln Ser Leu Thr Leu Phe Val Lys Asp Tyr Pro Ala Thr Ser Ile Glu 
545                 550                 555                 560 
Asp Ala Thr Asp Tyr Ile Arg Val Thr Val Ser Glu Ser Arg Gln Asn 
                565                 570                 575     
Ile Leu Lys Asn Leu Leu Gln Pro Ser Glu Leu Pro Arg Glu Cys Arg 
            580                 585                 590         
Gln Ile Phe Trp Asn Met Val Lys Ile Ile Asn Leu Phe Tyr Leu His 
        595                 600                 605             
Ser Asp Asp Phe Thr Ser Pro Thr Ala Met Leu Glu His Met Gln Gly 
    610                 615                 620                 
Leu Leu Tyr Asn Pro Val Ile 
625                 630     

<210> 43
<211> 631
<212> PRT
<213> Artificial Sequence


<220> 
<223> variant 3

<400> 43
Met Ala Ala Leu Ser Phe Thr Thr Ile Ser Thr Thr Ala Asn Tyr Ala 
1               5                   10                  15      
Ile Pro Lys Leu Pro Ser Thr Asn Val Asn Gly Arg Ser Arg Asp Thr 
            20                  25                  30          
Arg Tyr His Val Leu Ile Arg Ser Ala Ala Gly Ser Asn Phe Gln Phe 
        35                  40                  45              
Asn Gly Arg Lys Lys Phe Asn Pro Arg Thr His Gln Lys Val Lys Ser 
    50                  55                  60                  
Leu Ser Val Glu Asp Ser Ser Asn Val Leu Ile Lys Ala Glu Lys Glu 
65                  70                  75                  80  
Asn Arg Glu Lys Lys Ser Phe Gly Ser Met Cys Val Asp Asp Asn Leu 
                85                  90                  95      
Thr Arg Ile Gln Met Leu Phe Leu Glu Ile Met Arg Arg Trp Ser Ser 
            100                 105                 110         
Leu Ser Ala Tyr Asp Thr Val His Gly Ala Trp Pro Leu Asn Leu Ile 
        115                 120                 125             
Val Gly Leu Ser Arg Val Asn His Leu Glu Ser Leu Gly Ile Ala Arg 
    130                 135                 140                 
His Phe Lys Leu Glu Ile Lys Glu Val Leu Asp Asp Leu Tyr Arg Tyr 
145                 150                 155                 160 
Tyr Ile Glu Asn Glu Met Val Lys Gly Met Pro Ser Ala Ser Glu Ile 
                165                 170                 175     
Met Thr Ser Ser Ile Ser Phe Lys Ile Leu Arg Trp Asn Gly Tyr Asp 
            180                 185                 190         
Val Ser Pro Asp Val Phe Phe Ser Tyr Leu Arg Asp Thr Asp Phe Leu 
        195                 200                 205             
Pro Phe Leu Asp Asn Thr Gly Gln Ala Thr Met Ala Leu Leu Asn Leu 
    210                 215                 220                 
Tyr Lys Ala Ser Gln Met Arg Phe Pro Gly Glu Arg Ile Leu Asp Glu 
225                 230                 235                 240 
Ala Met Ser Phe Ser Gln Asn Tyr Leu Glu Asn Ile Lys Val Gly Asp 
                245                 250                 255     
Gln Ser Gly Ala Leu Lys Asp Ile Glu Ala Glu Val Arg His Ala Leu 
            260                 265                 270         
Asp Val Pro Trp Met Ala Gly Leu Glu Arg Ile Glu His Leu Arg Tyr 
        275                 280                 285             
Met Lys Gly Phe Gly Tyr Asp Asp Ile Tyr Ile Gly Glu Thr Ser Ser 
    290                 295                 300                 
Arg Ile Pro Trp Thr Gly Lys Asp Ile Phe Leu Ser Leu Ala Lys Gln 
305                 310                 315                 320 
Asp Phe Asn Leu Cys Gln Glu Ala Gln Gln Glu Asp Leu Lys Ala Leu 
                325                 330                 335     
Asp Met Trp Ser Val Asp Ser Lys Leu Gly Asp Leu His Phe Ala Arg 
            340                 345                 350         
Gln Met Leu Val Gly Cys Tyr Phe Ser Ala Ala Ser Thr Leu Phe Ser 
        355                 360                 365             
Pro Glu Met Ser Ser Thr Arg Ile Val Phe Thr Lys Asn Ala Val Leu 
    370                 375                 380                 
Thr Thr Leu Lys Asp Asp Phe Tyr Asp Val Glu Gly Ser Leu Glu Asp 
385                 390                 395                 400 
Ile Gln Ser Phe Val Glu Ala Ile Lys Arg Trp Asp Pro Ile Val Val 
                405                 410                 415     
Cys Asn Cys Ser Ala Asn Val Lys Arg Leu Phe Ser Ala Ile Tyr Asn 
            420                 425                 430         
Ser Val Asn Asp Ile Gly Gln Asp Ile Trp Ile Phe Gln Gly Trp Asp 
        435                 440                 445             
Ile Ser Thr Gln Leu Arg Glu Ile Trp Tyr Glu Val Ala Ile Ser Met 
    450                 455                 460                 
Met Lys Glu Ala Glu Trp Thr Met Thr Gly Phe Leu Pro Thr Val Glu 
465                 470                 475                 480 
Glu Tyr Met Glu Asn Gly Arg Thr Ser Leu Ala Leu Glu Pro Ile Ile 
                485                 490                 495     
Phe Thr Ser Leu Phe Tyr Leu Gly Pro Lys Ile Ser Glu Gln Arg Ile 
            500                 505                 510         
His Glu Tyr Lys Arg Leu Arg Gln Val Leu Asn Thr Cys Gly Arg Leu 
        515                 520                 525             
Leu Asn Asp Ser Gln Ser Tyr Lys Met Glu Ile Lys Gln Gly Lys Leu 
    530                 535                 540                 
Asn Ser Leu Ser Leu Phe Val Lys Glu Tyr Pro Ala Thr Ser Ile Glu 
545                 550                 555                 560 
Asp Ala Ser Glu Trp Ile Arg Leu Thr Val Ser Glu Ser Arg Gln Asn 
                565                 570                 575     
Ile Leu Arg Asn Ile Leu Gln Pro Ser Glu Leu Pro Arg Glu Cys Lys 
            580                 585                 590         
Gln Ile Phe Trp Asn Met Val Lys Ile Ile Gln Leu Phe Tyr Leu His 
        595                 600                 605             
Ser Asp Glu Phe Thr Ser Pro Thr Ala Met Leu Glu His Met Gln Ala 
    610                 615                 620                 
Val Leu Trp Asn Pro Val Leu 
625                 630     

<210> 44
<211> 631
<212> PRT
<213> Artificial Sequence


<220> 
<223> variant 4

<400> 44
Met Ala Ala Leu Ser Phe Ser Thr Ile Ser Thr Thr Ala Asn Tyr Ala 
1               5                   10                  15      
Ile Pro Lys Ile Pro Thr Ser Asn Leu Gln Gly Arg Ser Arg Asp Thr 
            20                  25                  30          
Met Tyr His Val Leu Ile Arg Ser Ala Gly Ala Thr Asn Tyr Asn Phe 
        35                  40                  45              
Gln Gly Arg Arg Lys Phe Gln Pro Arg Thr His Gln Lys Val Lys Ser 
    50                  55                  60                  
Leu Ser Val Glu Asp Ser Ser Asn Val Val Ile Lys Ala Glu Asn Glu 
65                  70                  75                  80  
Asn Arg Glu Lys Lys Ser Phe Gly Ser Met Cys Ile Asp Asp Asn Val 
                85                  90                  95      
Thr Arg Leu Asn Met Leu Phe Leu Glu Ile Lys Arg Arg Tyr Ser Ser 
            100                 105                 110         
Leu Thr Gly Tyr Asp Thr Val His Gly Ala Tyr Pro Ile Asn Leu Ile 
        115                 120                 125             
Leu Gly Leu Ser Met Val Asn His Leu Glu Ser Leu Gly Ile Ala Arg 
    130                 135                 140                 
His Phe Met Leu Glu Ile Arg Glu Val Leu Asp Asp Val Phe Arg Phe 
145                 150                 155                 160 
Trp Ile Glu Asn Glu Met Val Lys Gly Lys Pro Ser Ala Ser Asp Ile 
                165                 170                 175     
Met Ser Thr Ser Ile Ser Phe Lys Ile Leu Arg Trp Asn Gly Tyr Asp 
            180                 185                 190         
Val Ser Pro Asp Val Phe Phe Ser Tyr Leu Arg Glu Ser Asp Phe Leu 
        195                 200                 205             
Pro Phe Leu Glu Asn Ser Gly Gln Ala Ser Met Ala Leu Leu Asn Leu 
    210                 215                 220                 
Tyr Lys Ala Ser Gln Met Met Phe Pro Gly Glu Met Ile Leu Glu Glu 
225                 230                 235                 240 
Ala Arg Ser Phe Ser Gln Asn Trp Leu Glu Gln Ile Lys Val Gly Asp 
                245                 250                 255     
Gln Ser Gly Ala Leu Lys Asp Ile Glu Ala Glu Val Met His Ala Leu 
            260                 265                 270         
Asp Val Pro Phe Met Ala Gly Leu Glu Arg Ile Glu His Leu Arg Tyr 
        275                 280                 285             
Met Lys Ala Phe Ala Phe Asp Asp Val Trp Ile Gly Glu Thr Ser Ser 
    290                 295                 300                 
Arg Ile Pro Phe Thr Gly Lys Glu Leu Phe Leu Ser Leu Ala Lys Gln 
305                 310                 315                 320 
Asp Phe Asn Ile Cys Gln Glu Ala Gln Gln Glu Asp Leu Lys Ala Leu 
                325                 330                 335     
Glu Lys Trp Ser Val Asp Thr Arg Ile Gly Asp Leu His Phe Ala Arg 
            340                 345                 350         
Gln Met Leu Leu Gly Cys Tyr Phe Ser Ala Ala Ser Thr Leu Tyr Ser 
        355                 360                 365             
Pro Glu Met Ser Thr Thr Arg Ile Val Trp Thr Lys Asn Ala Val Leu 
    370                 375                 380                 
Thr Thr Leu Lys Asp Asp Phe Tyr Asp Val Asp Gly Ser Ile Glu Asp 
385                 390                 395                 400 
Ile Gln Ser Phe Val Glu Ala Ile Lys Arg Trp Asp Pro Leu Val Leu 
                405                 410                 415     
Cys Asn Cys Ser Ala Asn Val Lys Lys Leu Phe Thr Ala Ile Tyr Asn 
            420                 425                 430         
Thr Val Asn Asp Val Ala Gln Asp Ile Trp Ile Phe Gln Gly Trp Asp 
        435                 440                 445             
Ile Ser Thr Gln Leu Arg Glu Ile Trp Tyr Glu Val Ala Ile Thr Arg 
    450                 455                 460                 
Met Lys Glu Ala Glu Trp Thr Met Thr Gly Tyr Val Pro Ser Leu Glu 
465                 470                 475                 480 
Glu Tyr Met Glu Asn Gly Arg Thr Ser Ile Ala Leu Glu Pro Ile Ile 
                485                 490                 495     
Phe Thr Ser Leu Phe Phe Leu Gly Pro Lys Val Ser Glu Gln Met Ile 
            500                 505                 510         
His Glu Tyr Lys Arg Leu Lys Gln Leu Leu Asn Thr Cys Gly Arg Leu 
        515                 520                 525             
Leu Asn Asp Thr Gln Thr Tyr Lys Arg Glu Ile Met Gln Gly Lys Leu 
    530                 535                 540                 
Gln Thr Leu Ser Leu Phe Val Arg Glu Tyr Pro Ala Thr Ser Ile Glu 
545                 550                 555                 560 
Asp Ala Ser Glu Trp Ile Arg Leu Thr Leu Ser Glu Ser Arg Gln Asn 
                565                 570                 575     
Ile Leu Arg Gln Leu Leu Gln Pro Ser Glu Ile Pro Arg Glu Cys Lys 
            580                 585                 590         
Gln Ile Tyr Trp Asn Met Ile Lys Val Ile Gln Leu Phe Tyr Leu His 
        595                 600                 605             
Ser Asp Glu Phe Thr Ser Pro Thr Ala Met Leu Glu His Met Gln Ala 
    610                 615                 620                 
Val Leu Phe Asn Pro Val Leu 
625                 630     

<210> 45
<211> 631
<212> PRT
<213> Artificial Sequence


<220> 
<223> variant 5

<400> 45
Met Ala Ala Leu Ser Phe Ser Thr Ile Ser Thr Thr Gly Asn Tyr Ala 
1               5                   10                  15      
Ile Pro Lys Leu Pro Ser Ser Asn Leu Gln Gly Arg Ser Arg Glu Thr 
            20                  25                  30          
Lys Tyr His Val Leu Val Arg Ser Gly Gly Ala Ser Asn Phe Asn Phe 
        35                  40                  45              
Asn Ala Arg Lys Met Phe Asn Pro Arg Thr His Gln Lys Val Met Ser 
    50                  55                  60                  
Leu Ser Val Glu Glu Ser Ser Asn Val Leu Ile Lys Ala Glu Lys Glu 
65                  70                  75                  80  
Gln Arg Glu Asn Lys Ser Phe Gly Ser Met Cys Ile Glu Asp Asn Ile 
                85                  90                  95      
Thr Met Ile Asn Met Leu Phe Val Glu Ile Arg Arg Arg Tyr Ser Ser 
            100                 105                 110         
Val Thr Ala Tyr Asp Thr Val His Gly Ala Tyr Pro Ile Asn Leu Leu 
        115                 120                 125             
Leu Gly Leu Ser Met Val Asn His Leu Glu Ser Leu Gly Ile Gly Lys 
    130                 135                 140                 
His Phe Lys Leu Glu Ile Lys Glu Val Leu Asp Asp Val Trp Arg Phe 
145                 150                 155                 160 
Trp Ile Asp Asn Asp Met Leu Met Gly Met Pro Ser Ala Ser Asp Ile 
                165                 170                 175     
Lys Thr Ser Ser Ile Ser Phe Lys Ile Leu Arg Trp Asn Gly Tyr Asp 
            180                 185                 190         
Val Ser Pro Asp Leu Phe Phe Thr Tyr Ile Arg Asp Ser Asp Phe Leu 
        195                 200                 205             
Pro Phe Val Glu Gln Ser Gly Gln Ala Thr Met Ala Leu Leu Asn Leu 
    210                 215                 220                 
Tyr Lys Ala Ser Gln Lys Met Phe Pro Gly Glu Arg Leu Leu Glu Glu 
225                 230                 235                 240 
Ala Lys Ser Phe Ser Gln Asn Tyr Leu Glu Asn Ile Met Leu Gly Asp 
                245                 250                 255     
Gln Ser Gly Gly Leu Lys Asp Val Asp Gly Glu Val Lys His Ala Leu 
            260                 265                 270         
Asp Val Pro Trp Met Ala Gly Ile Glu Arg Val Glu His Leu Arg Phe 
        275                 280                 285             
Met Met Ala Phe Ala Phe Asp Asp Ile Trp Ile Gly Glu Thr Ser Ser 
    290                 295                 300                 
Arg Ile Pro Phe Thr Gly Lys Asp Leu Phe Leu Ser Leu Ala Lys Asn 
305                 310                 315                 320 
Asp Phe Asn Ile Cys Gln Glu Ala Gln Asn Glu Asp Leu Lys Gly Leu 
                325                 330                 335     
Glu Lys Trp Ser Val Asp Ser Arg Leu Gly Asp Leu His Phe Ala Arg 
            340                 345                 350         
Asn Lys Ile Ile Ala Cys Tyr Phe Ser Gly Ala Thr Thr Leu Phe Ser 
        355                 360                 365             
Pro Glu Met Ser Thr Ser Arg Ile Val Trp Thr Lys Asn Ala Val Leu 
    370                 375                 380                 
Thr Thr Leu Arg Asp Asp Phe Tyr Asp Val Asp Gly Ser Ile Glu Asp 
385                 390                 395                 400 
Ile Gln Ser Phe Ile Glu Ala Val Lys Arg Trp Asp Pro Ile Val Leu 
                405                 410                 415     
Cys Asn Cys Ser Ala Asn Val Lys Lys Leu Phe Ser Ala Ile Tyr Asn 
            420                 425                 430         
Thr Val Asn Asp Val Ala Gln Glu Ile Trp Ile Tyr Gln Ala Phe Glu 
        435                 440                 445             
Val Ser Thr Gln Leu Arg Glu Ile Trp Phe Glu Val Ala Ile Ser Met 
    450                 455                 460                 
Met Lys Glu Ala Glu Trp Thr Lys Ser Gly Phe Ile Pro Ser Leu Glu 
465                 470                 475                 480 
Glu Tyr Met Glu Asn Gly Arg Thr Ser Ile Gly Leu Glu Pro Ile Ile 
                485                 490                 495     
Phe Ser Ser Ile Phe Phe Leu Gly Pro Arg Ile Thr Asp Gln Met Ile 
            500                 505                 510         
His Glu Tyr Lys Arg Leu Met Gln Leu Val Asn Thr Cys Gly Arg Leu 
        515                 520                 525             
Leu Asn Asp Ser Gln Thr Phe Lys Arg Glu Val Met Gln Gly Lys Val 
    530                 535                 540                 
Asn Ser Leu Ser Leu Phe Val Arg Glu Tyr Pro Ala Ser Ser Ile Glu 
545                 550                 555                 560 
Asp Ala Thr Glu Trp Val Arg Leu Thr Val Ser Glu Ser Arg Gln Asn 
                565                 570                 575     
Leu Leu Arg Asn Ile Leu Asn Pro Ser Glu Val Pro Arg Glu Cys Lys 
            580                 585                 590         
Gln Leu Phe Trp Asn Met Val Lys Ile Leu Gln Leu Phe Tyr Leu His 
        595                 600                 605             
Thr Asp Asp Phe Thr Ser Pro Thr Ala Met Leu Glu His Met Asn Ala 
    610                 615                 620                 
Val Leu Trp Gln Pro Val Ile 
625                 630     

<210> 46
<211> 631
<212> PRT
<213> Artificial Sequence


<220> 
<223> variant 6

<400> 46
Met Ala Ala Val Ser Trp Ser Thr Ile Ser Thr Thr Ala Gln Tyr Ala 
1               5                   10                  15      
Leu Pro Lys Ile Pro Ser Ser Asn Leu Asn Ala Arg Ser Met Asp Thr 
            20                  25                  30          
Arg Tyr His Val Leu Ile Arg Ser Ala Gly Ala Ser Asn Trp Asn Phe 
        35                  40                  45              
Asn Ala Arg Lys Lys Trp Gln Pro Arg Thr His Gln Lys Val Lys Ser 
    50                  55                  60                  
Leu Ser Val Glu Asp Ser Thr Asn Leu Leu Ile Lys Ala Glu Arg Glu 
65                  70                  75                  80  
Asn Arg Glu Lys Lys Ser Phe Gly Ser Met Cys Ile Asp Asp Asn Ile 
                85                  90                  95      
Thr Arg Ile Gln Met Leu Trp Leu Glu Ile Met Arg Arg Tyr Ser Ser 
            100                 105                 110         
Ile Ser Ala Tyr Asp Ser Val His Ala Ala Tyr Pro Leu Asn Ile Ile 
        115                 120                 125             
Leu Gly Leu Ser Met Val Asn His Leu Asp Ser Leu Gly Ile Ala Arg 
    130                 135                 140                 
His Phe Lys Leu Glu Ile Lys Glu Val Leu Asp Asp Leu Tyr Met Phe 
145                 150                 155                 160 
Phe Ile Glu Gln Glu Met Val Arg Gly Met Pro Ser Ala Thr Asp Ile 
                165                 170                 175     
Met Ser Ser Ser Ile Ser Phe Lys Ile Leu Arg Trp Gln Gly Tyr Glu 
            180                 185                 190         
Val Ser Pro Asp Val Phe Phe Ser Tyr Leu Arg Asp Thr Asp Phe Leu 
        195                 200                 205             
Pro Trp Ile Asp Asn Ser Gly Asn Ala Thr Met Ala Leu Leu Asn Leu 
    210                 215                 220                 
Tyr Lys Ala Ser Gln Met Met Phe Pro Gly Glu Lys Ile Leu Glu Glu 
225                 230                 235                 240 
Ala Lys Ser Phe Ser Gln Asn Tyr Leu Glu Asn Ile Lys Val Gly Asp 
                245                 250                 255     
Gln Ser Gly Gly Leu Met Asp Ile Glu Ala Glu Val Lys His Ala Leu 
            260                 265                 270         
Asp Leu Pro Trp Met Gly Gly Leu Glu Arg Val Glu His Leu Arg Tyr 
        275                 280                 285             
Met Met Gly Phe Ala Phe Glu Asp Leu Trp Ile Gly Glu Thr Ser Ser 
    290                 295                 300                 
Lys Ile Pro Phe Thr Gly Lys Asp Leu Phe Leu Ser Leu Ala Lys Asn 
305                 310                 315                 320 
Asp Phe Asn Ile Cys Gln Glu Ala Gln Gln Glu Asp Leu Lys Ala Leu 
                325                 330                 335     
Glu Lys Trp Ser Leu Asp Ser Lys Leu Gly Glu Leu His Phe Ala Arg 
            340                 345                 350         
Gln Lys Leu Val Ala Cys Tyr Trp Ser Ala Ala Thr Thr Leu Tyr Ser 
        355                 360                 365             
Pro Glu Met Ser Ser Thr Arg Leu Val Trp Thr Lys Asn Ala Val Leu 
    370                 375                 380                 
Thr Thr Ile Met Asp Asp Phe Tyr Asp Val Asp Gly Ser Ile Glu Asp 
385                 390                 395                 400 
Ile Gln Ser Phe Val Glu Ala Val Lys Arg Trp Asp Pro Ile Val Leu 
                405                 410                 415     
Cys Gln Cys Ser Ala Asn Val Lys Lys Leu Phe Ser Ala Ile Phe Asn 
            420                 425                 430         
Thr Val Asn Asp Ile Gly Gln Asp Ile Trp Ile Phe Gln Ala Trp Asp 
        435                 440                 445             
Ile Ser Thr Gln Leu Arg Glu Leu Trp Phe Asp Leu Ala Ile Ser Met 
    450                 455                 460                 
Met Lys Glu Ala Glu Trp Thr Lys Thr Gly Phe Val Pro Ser Val Glu 
465                 470                 475                 480 
Glu Tyr Met Glu Asn Gly Arg Thr Ser Leu Ala Ile Glu Pro Ile Ile 
                485                 490                 495     
Phe Thr Ser Leu Tyr Phe Leu Gly Pro Lys Leu Ser Glu Gln Met Val 
            500                 505                 510         
His Glu Tyr Lys Met Leu Lys Gln Leu Val Asn Thr Cys Gly Arg Leu 
        515                 520                 525             
Ile Asn Asp Thr Gln Ser Tyr Lys Met Glu Val Lys Gln Gly Arg Val 
    530                 535                 540                 
Asn Ser Val Ser Leu Phe Val Lys Glu Tyr Pro Ala Ser Ser Ile Glu 
545                 550                 555                 560 
Asp Ala Thr Glu Trp Ile Arg Leu Thr Val Ser Glu Thr Arg Gln Asn 
                565                 570                 575     
Leu Leu Lys Asn Leu Val Gln Pro Ser Glu Ile Pro Lys Glu Cys Lys 
            580                 585                 590         
Gln Leu Phe Trp Asn Met Val Lys Ile Ile Asn Leu Phe Tyr Val His 
        595                 600                 605             
Ser Asp Glu Phe Thr Ser Pro Thr Ala Lys Leu Glu His Met Gln Ala 
    610                 615                 620                 
Ile Leu Phe Asn Pro Val Leu 
625                 630     

<210> 47
<211> 631
<212> PRT
<213> Artificial Sequence


<220> 
<223> variant 7

<400> 47
Met Gly Gly Leu Ser Trp Ser Thr Ile Thr Thr Thr Ala Asn Trp Ala 
1               5                   10                  15      
Ile Pro Lys Leu Pro Ser Ser Asn Val Gln Gly Arg Ser Arg Asp Thr 
            20                  25                  30          
Met Tyr His Val Leu Ile Lys Ser Gly Gly Ala Thr Asn Phe Asn Phe 
        35                  40                  45              
Asn Gly Arg Lys Arg Phe Gln Pro Arg Thr His Gln Lys Ile Arg Ser 
    50                  55                  60                  
Leu Ser Val Asp Asp Ser Ser Asn Val Leu Ile Arg Ala Glu Lys Asp 
65                  70                  75                  80  
Asn Arg Glu Lys Lys Ser Phe Gly Ser Met Cys Ile Asp Asp Asn Ile 
                85                  90                  95      
Thr Arg Ile Asn Lys Leu Tyr Leu Asp Ile Lys Met Arg Tyr Ser Ser 
            100                 105                 110         
Ile Ser Ala Tyr Asp Thr Val His Gly Ala Tyr Pro Ile Asn Leu Ile 
        115                 120                 125             
Leu Gly Leu Ser Met Val Asn His Leu Glu Ser Leu Gly Ile Ala Arg 
    130                 135                 140                 
His Phe Lys Leu Glu Ile Arg Glu Val Leu Asp Asp Leu Tyr Arg Phe 
145                 150                 155                 160 
Trp Ile Glu Asn Glu Met Val Lys Gly Met Pro Ser Ala Ser Asp Ile 
                165                 170                 175     
Met Thr Ser Ser Ile Thr Phe Lys Ile Leu Arg Trp Asn Gly Tyr Asp 
            180                 185                 190         
Val Ser Pro Asp Val Phe Phe Ser Tyr Leu Arg Asp Ser Asp Phe Val 
        195                 200                 205             
Pro Phe Leu Glu Asn Ser Ala Gln Ala Ser Met Ala Leu Leu Gln Leu 
    210                 215                 220                 
Tyr Lys Ala Ser Gln Arg Met Phe Pro Gly Glu Arg Val Leu Glu Glu 
225                 230                 235                 240 
Ala Met Ser Phe Ser Gln Asn Tyr Leu Glu Asn Leu Met Val Gly Glu 
                245                 250                 255     
Gln Ser Gly Ala Val Met Glu Ile Glu Ala Glu Val Lys His Ala Leu 
            260                 265                 270         
Asp Leu Pro Trp Met Ala Gly Leu Glu Arg Ile Asp His Leu Lys Trp 
        275                 280                 285             
Met Arg Ala Phe Ala Phe Asp Asp Ile Trp Leu Gly Glu Ser Ser Ser 
    290                 295                 300                 
Arg Val Pro Phe Thr Gly Lys Asp Leu Phe Leu Ser Leu Ala Lys Gln 
305                 310                 315                 320 
Asp Phe Asn Ile Cys Gln Glu Ala Gln Gln Glu Asp Leu Met Gly Val 
                325                 330                 335     
Glu Lys Trp Ser Val Asp Ser Lys Ile Ala Asp Leu His Phe Ala Arg 
            340                 345                 350         
Gln Lys Ile Val Ala Cys Tyr Tyr Ser Ala Ala Ser Thr Leu Phe Ser 
        355                 360                 365             
Pro Glu Met Ser Ser Thr Arg Ile Val Trp Thr Lys Asn Ala Leu Leu 
    370                 375                 380                 
Ser Thr Leu Met Asp Asp Phe Tyr Asp Leu Glu Gly Ser Ile Glu Asp 
385                 390                 395                 400 
Ile Gln Thr Phe Ile Glu Ala Ile Lys Arg Trp Asp Pro Ile Leu Leu 
                405                 410                 415     
Cys Asn Cys Ser Ala Asn Ile Lys Lys Leu Phe Ser Ala Ile Tyr Gln 
            420                 425                 430         
Thr Val Asn Asp Ile Ala Asn Asp Ile Trp Ile Trp Gln Gly Trp Asp 
        435                 440                 445             
Ile Ser Thr Gln Leu Arg Glu Leu Trp Tyr Glu Val Gly Ile Ser Met 
    450                 455                 460                 
Met Lys Glu Ala Glu Trp Thr Lys Thr Gly Tyr Ile Pro Ser Leu Glu 
465                 470                 475                 480 
Glu Tyr Met Glu Asn Gly Arg Thr Ser Ile Ala Leu Glu Pro Ile Ile 
                485                 490                 495     
Phe Thr Ser Leu Phe Trp Leu Gly Pro Arg Leu Ser Glu Gln Met Ile 
            500                 505                 510         
His Glu Tyr Lys Lys Leu Met Gln Leu Leu Asn Thr Cys Gly Arg Leu 
        515                 520                 525             
Leu Asn Asp Ser Gln Thr Tyr Lys Arg Glu Val Lys Gln Gly Lys Leu 
    530                 535                 540                 
Asn Ser Val Thr Leu Phe Val Lys Glu Tyr Pro Ala Thr Ser Val Glu 
545                 550                 555                 560 
Glu Ala Ser Glu Trp Ile Met Leu Thr Leu Thr Glu Ser Arg Gln Gln 
                565                 570                 575     
Ile Leu Arg Asn Ile Leu Gln Pro Ser Glu Ile Pro Arg Glu Cys Lys 
            580                 585                 590         
Gln Ile Phe Trp Asn Arg Val Lys Ile Ile Gln Leu Phe Tyr Leu His 
        595                 600                 605             
Ser Asp Glu Trp Ser Ser Pro Thr Ala Met Leu Glu His Met Asn Ala 
    610                 615                 620                 
Ile Ile Trp Gln Pro Val Leu 
625                 630     

<210> 48
<211> 631
<212> PRT
<213> Artificial Sequence


<220> 
<223> variant 8

<400> 48
Met Gly Ala Val Thr Phe Ser Ser Ile Ser Thr Thr Ala Asn Tyr Gly 
1               5                   10                  15      
Ile Pro Met Ile Pro Ser Ser Asn Leu Gln Gly Arg Ser Arg Asp Thr 
            20                  25                  30          
Arg Phe His Val Leu Ile Met Ser Ala Ala Ala Ser Gln Phe Asn Trp 
        35                  40                  45              
Gln Gly Lys Met Met Phe Asn Pro Lys Thr His Gln Arg Val Met Ser 
    50                  55                  60                  
Leu Ser Val Glu Asp Ser Ser Asn Val Leu Val Met Ala Glu Lys Glu 
65                  70                  75                  80  
Asn Arg Glu Asn Lys Ser Phe Gly Ser Met Cys Ile Asp Glu Asn Leu 
                85                  90                  95      
Thr Arg Ile Asn Met Leu Phe Leu Asp Ile Met Arg Met Tyr Ser Ser 
            100                 105                 110         
Val Ser Gly Phe Asp Thr Val His Gly Ala Tyr Pro Val Asn Leu Ile 
        115                 120                 125             
Val Gly Leu Ser Met Val Asn His Leu Glu Ser Leu Gly Ile Ala Met 
    130                 135                 140                 
His Phe Lys Val Glu Ile Arg Glu Leu Leu Asp Asp Val Trp Met Phe 
145                 150                 155                 160 
Trp Ile Glu Gln Glu Met Ile Arg Gly Met Pro Thr Gly Ser Asp Ile 
                165                 170                 175     
Met Thr Ser Ser Ile Ser Phe Lys Ile Leu Arg Trp Asn Gly Tyr Asp 
            180                 185                 190         
Val Ser Pro Asp Val Phe Phe Thr Tyr Val Arg Asp Ser Glu Phe Leu 
        195                 200                 205             
Pro Phe Ile Glu Asn Ser Gly Gln Ala Thr Met Ala Leu Leu Asn Leu 
    210                 215                 220                 
Tyr Lys Ala Ser Gln Met Lys Tyr Pro Gly Glu Arg Ile Leu Glu Glu 
225                 230                 235                 240 
Ala Lys Ser Phe Ser Gln Asn Tyr Leu Asp Asn Ile Lys Val Gly Asp 
                245                 250                 255     
Gln Ser Gly Ala Ile Arg Asp Leu Glu Gly Asp Val Lys His Ala Leu 
            260                 265                 270         
Asp Val Pro Trp Met Gly Gly Leu Asp Arg Leu Glu His Leu Lys Tyr 
        275                 280                 285             
Met Arg Ala Phe Ala Phe Asp Asp Ile Trp Ile Gly Glu Thr Ser Ser 
    290                 295                 300                 
Arg Ile Pro Phe Thr Gly Arg Asp Leu Phe Leu Ser Leu Ala Lys Gln 
305                 310                 315                 320 
Asp Phe Asn Val Cys Gln Glu Ala Gln Gln Glu Asp Leu Arg Ala Leu 
                325                 330                 335     
Glu Lys Trp Ser Val Asp Ser Lys Leu Gly Asp Leu His Phe Ala Arg 
            340                 345                 350         
Asn Met Leu Val Ala Cys Tyr Trp Ser Gly Ala Ser Ser Ile Trp Ser 
        355                 360                 365             
Pro Glu Met Ser Thr Thr Arg Val Val Trp Thr Lys Asn Ala Ile Ile 
    370                 375                 380                 
Thr Thr Leu Met Asp Asp Phe Tyr Asp Ile Glu Gly Ser Ile Glu Asp 
385                 390                 395                 400 
Ile Gln Ser Phe Val Glu Ala Val Lys Arg Trp Asp Pro Leu Val Leu 
                405                 410                 415     
Cys Asn Cys Ser Ala Asn Val Lys Met Leu Phe Ser Ala Ile Tyr Asn 
            420                 425                 430         
Thr Val Asn Asp Ile Ala Gln Glu Ile Trp Ile Tyr Asn Gly Trp Asp 
        435                 440                 445             
Leu Thr Thr Gln Leu Met Glu Ile Tyr Phe Asp Leu Gly Ile Ser Met 
    450                 455                 460                 
Arg Lys Glu Ala Glu Trp Thr Met Thr Ala Phe Ile Pro Ser Leu Asp 
465                 470                 475                 480 
Glu Tyr Lys Asp Asn Gly Arg Thr Ser Ile Ala Leu Glu Pro Ile Ile 
                485                 490                 495     
Phe Thr Ser Ile Phe Phe Leu Gly Pro Arg Val Ser Glu Gln Arg Leu 
            500                 505                 510         
His Glu Tyr Lys Arg Leu Met Gln Leu Leu Asn Thr Cys Ala Arg Leu 
        515                 520                 525             
Leu Asn Asp Ser Gln Ser Trp Met Arg Glu Leu Arg Gln Gly Met Leu 
    530                 535                 540                 
Asn Ser Leu Ser Leu Phe Val Lys Glu Trp Pro Gly Thr Ser Ile Glu 
545                 550                 555                 560 
Asp Ala Thr Glu Tyr Ile Arg Leu Thr Leu Ser Asp Thr Arg Gln Asn 
                565                 570                 575     
Ile Leu Met Gln Leu Leu Gln Pro Thr Glu Val Pro Arg Asp Cys Arg 
            580                 585                 590         
Gln Ile Phe Trp Asn Met Val Lys Val Val Gln Val Tyr Tyr Leu His 
        595                 600                 605             
Ser Asp Asp Phe Thr Thr Pro Thr Ala Met Leu Glu His Met Gln Ala 
    610                 615                 620                 
Val Leu Trp Asn Pro Leu Ile 
625                 630     

<210> 49
<211> 631
<212> PRT
<213> Artificial Sequence


<220> 
<223> variant 9

<400> 49
Met Ala Ala Val Ser Phe Ser Thr Ile Thr Ser Thr Ala Asn Tyr Ala 
1               5                   10                  15      
Ile Pro Met Leu Pro Thr Ser Gln Val Gln Gly Lys Ser Arg Asp Thr 
            20                  25                  30          
Arg Phe His Val Leu Ile Lys Thr Ala Gly Ala Ser Gln Phe Asn Tyr 
        35                  40                  45              
Gln Ala Arg Lys Lys Phe Gln Pro Arg Thr His Gln Lys Val Lys Ser 
    50                  55                  60                  
Leu Ser Leu Glu Asp Ser Ser Asn Val Leu Val Met Ala Asp Arg Glu 
65                  70                  75                  80  
Gln Arg Glu Lys Lys Ser Phe Gly Ser Met Cys Ile Asp Glu Asn Ile 
                85                  90                  95      
Thr Arg Val Asn Met Leu Phe Leu Glu Ile Lys Arg Met Trp Ser Ser 
            100                 105                 110         
Leu Ser Ala Phe Glu Thr Val His Gly Ala Trp Pro Ile Asn Ile Ile 
        115                 120                 125             
Leu Gly Leu Ser Lys Val Asn His Leu Glu Ser Leu Gly Ile Ala Lys 
    130                 135                 140                 
His Phe Lys Ile Glu Ile Met Glu Leu Leu Asp Glu Val Trp Arg Tyr 
145                 150                 155                 160 
Trp Ile Asp Asn Asp Lys Leu Met Gly Met Pro Ser Ala Ser Asp Ile 
                165                 170                 175     
Met Ser Ser Ser Ile Thr Phe Lys Ile Leu Arg Trp Asn Gly Tyr Asp 
            180                 185                 190         
Val Ser Pro Asp Val Phe Phe Ser Tyr Val Met Asp Ser Glu Phe Ile 
        195                 200                 205             
Pro Phe Leu Glu Gln Ser Gly Gln Ala Thr Met Ala Leu Leu Asn Leu 
    210                 215                 220                 
Tyr Lys Ala Ser Gln Met Met Phe Pro Gly Glu Arg Ile Leu Glu Glu 
225                 230                 235                 240 
Ala Met Ser Phe Ser Gln Gln Tyr Leu Glu Asn Leu Arg Val Ala Asp 
                245                 250                 255     
Gln Ser Ala Ala Ile Lys Asp Leu Glu Gly Glu Val Arg His Ala Leu 
            260                 265                 270         
Asp Val Pro Tyr Arg Gly Gly Leu Glu Arg Leu Glu His Leu Arg Trp 
        275                 280                 285             
Met Lys Ala Phe Ala Phe Asp Asp Ile Trp Ile Gly Glu Thr Ser Ser 
    290                 295                 300                 
Arg Ile Pro Phe Thr Gly Lys Asp Ile Phe Leu Ser Leu Ala Lys Gln 
305                 310                 315                 320 
Asp Phe Asn Ile Cys Gln Glu Ala Gln Asn Glu Asp Leu Arg Ala Ile 
                325                 330                 335     
Glu Lys Trp Ser Val Asp Ser Lys Leu Gly Asp Leu His Phe Ala Arg 
            340                 345                 350         
Gln Arg Leu Val Gly Cys Tyr Tyr Ser Ala Ala Ser Thr Ile Phe Ser 
        355                 360                 365             
Pro Glu Met Ser Thr Thr Arg Ile Val Phe Thr Lys Asn Gly Val Leu 
    370                 375                 380                 
Ser Thr Leu Met Asp Asp Tyr Tyr Asp Val Glu Gly Ser Ile Asp Asp 
385                 390                 395                 400 
Ile Gln Ser Phe Val Glu Ala Val Met Arg Trp Asp Pro Ile Val Leu 
                405                 410                 415     
Cys Asn Cys Ser Gly Asn Ile Lys Lys Leu Phe Ser Ala Ile Tyr Asn 
            420                 425                 430         
Thr Val Asn Glu Ile Ala Asn Asp Val Trp Ile Tyr Asn Gly Trp Asp 
        435                 440                 445             
Ile Ser Thr Asn Leu Lys Glu Ile Phe Tyr Glu Val Ala Ile Ser Lys 
    450                 455                 460                 
Met Lys Glu Ala Glu Trp Thr Lys Thr Gly Trp Ile Pro Ser Leu Asp 
465                 470                 475                 480 
Glu Tyr Met Glu Asn Gly Arg Thr Ser Ile Ala Leu Glu Pro Ile Ile 
                485                 490                 495     
Phe Thr Ser Leu Phe Phe Leu Ala Pro Lys Leu Thr Glu Gln Met Ile 
            500                 505                 510         
His Glu Trp Lys Arg Leu Met Asn Leu Ile Asn Thr Cys Gly Arg Leu 
        515                 520                 525             
Leu Asn Asp Ser Gln Ser Trp Lys Arg Glu Ile Lys Gln Gly Lys Leu 
    530                 535                 540                 
Gln Thr Leu Ser Leu Phe Val Met Asp Phe Pro Ala Thr Ser Leu Glu 
545                 550                 555                 560 
Asp Ala Thr Glu Trp Leu Met Leu Thr Val Ser Glu Ser Arg Gln Asn 
                565                 570                 575     
Leu Leu Met Asn Leu Leu Gln Pro Ser Glu Leu Pro Lys Glu Cys Lys 
            580                 585                 590         
Asn Ile Phe Phe Asn Met Ile Lys Ile Leu Gln Leu Phe Tyr Leu His 
        595                 600                 605             
Ser Asp Glu Trp Thr Ser Pro Thr Ala Arg Val Glu His Met Asn Gly 
    610                 615                 620                 
Val Leu Phe Asn Pro Leu Val 
625                 630     

<210> 50
<211> 631
<212> PRT
<213> Artificial Sequence


<220> 
<223> variant 10

<400> 50
Met Gly Gly Leu Thr Phe Thr Thr Ile Ser Thr Thr Gly Asn Tyr Gly 
1               5                   10                  15      
Ile Pro Lys Leu Pro Ser Ser Asn Ile Gln Gly Lys Ser Met Asp Thr 
            20                  25                  30          
Met Tyr His Leu Leu Ile Arg Ser Ala Gly Ala Thr Gln Trp Asn Tyr 
        35                  40                  45              
Gln Ala Arg Arg Lys Phe Asn Pro Arg Thr His Gln Met Val Arg Ser 
    50                  55                  60                  
Leu Ser Ile Glu Asp Ser Ser Asn Val Leu Ile Lys Ala Glu Met Glu 
65                  70                  75                  80  
Asn Arg Glu Asn Lys Ser Phe Gly Ser Met Cys Ile Asp Asp Asn Ile 
                85                  90                  95      
Thr Lys Leu Asn Arg Leu Trp Val Glu Ile Arg Arg Arg Tyr Ser Ser 
            100                 105                 110         
Leu Ser Gly Trp Asp Thr Val His Ala Ala Tyr Pro Leu Asn Leu Ile 
        115                 120                 125             
Leu Gly Leu Ser Met Val Asn His Leu Glu Ser Leu Gly Ile Ala Lys 
    130                 135                 140                 
His Phe Lys Val Glu Ile Lys Glu Val Leu Asp Asp Val Trp Lys Tyr 
145                 150                 155                 160 
Trp Ile Glu Gln Glu Arg Leu Arg Ala Arg Pro Thr Ala Thr Asp Ile 
                165                 170                 175     
Met Thr Thr Ser Ile Ser Phe Lys Ile Leu Arg Trp Asn Gly Tyr Asp 
            180                 185                 190         
Val Ser Pro Asp Val Phe Phe Ser Tyr Leu Arg Glu Ser Asp Phe Val 
        195                 200                 205             
Pro Phe Leu Glu Gln Ser Gly Asn Ala Thr Met Ala Val Leu Gln Leu 
    210                 215                 220                 
Tyr Lys Ala Ser Gln Met Met Phe Pro Gly Glu Arg Val Leu Glu Glu 
225                 230                 235                 240 
Ala Lys Ser Phe Ser Gln Asn Tyr Leu Glu Asn Ile Met Val Gly Glu 
                245                 250                 255     
Gln Ser Gly Gly Ile Met Asp Val Glu Gly Asp Val Lys His Gly Leu 
            260                 265                 270         
Asp Leu Pro Trp Met Ala Gly Leu Glu Arg Ile Glu His Leu Met Tyr 
        275                 280                 285             
Met Lys Ala Phe Ala Phe Asp Asp Ile Trp Val Gly Glu Thr Ser Thr 
    290                 295                 300                 
Arg Leu Pro Phe Thr Gly Arg Asp Leu Phe Leu Ser Leu Ala Lys Gln 
305                 310                 315                 320 
Asp Phe Asn Ile Cys Gln Glu Ala Gln Gln Glu Asp Leu Met Ala Leu 
                325                 330                 335     
Glu Lys Trp Ser Val Asp Ser Lys Leu Gly Asp Leu His Phe Ala Arg 
            340                 345                 350         
Gln Lys Leu Ile Ala Cys Tyr Trp Ser Ala Ala Ser Thr Val Tyr Ser 
        355                 360                 365             
Pro Glu Met Ser Thr Ser Arg Leu Val Trp Thr Lys Gln Ala Val Ile 
    370                 375                 380                 
Thr Thr Ile Met Asp Asp Trp Tyr Asp Ile Glu Gly Ser Ile Asp Asp 
385                 390                 395                 400 
Ile Gln Ser Phe Val Asp Ala Val Lys Arg Trp Asp Pro Ile Val Leu 
                405                 410                 415     
Cys Asn Cys Ser Ala Asn Leu Lys Met Leu Phe Ser Ala Ile Tyr Asn 
            420                 425                 430         
Thr Val Asn Glu Leu Ala Gln Asp Ile Trp Ile Tyr Gln Gly Trp Asp 
        435                 440                 445             
Ile Ser Thr Gln Leu Met Asp Ile Trp Tyr Glu Ile Gly Ile Ser Met 
    450                 455                 460                 
Lys Met Glu Ala Glu Trp Thr Lys Thr Ala Trp Val Pro Ser Leu Glu 
465                 470                 475                 480 
Glu Tyr Lys Glu Asn Gly Arg Thr Ser Ile Ala Leu Glu Pro Ile Ile 
                485                 490                 495     
Phe Thr Thr Ile Phe Phe Val Gly Pro Met Leu Ser Glu Gln Arg Ile 
            500                 505                 510         
His Asp Tyr Lys Arg Leu Met Gln Leu Leu Asn Thr Cys Gly Arg Leu 
        515                 520                 525             
Leu Asn Asp Ser Gln Ser Trp Lys Arg Glu Val Arg Gln Gly Lys Leu 
    530                 535                 540                 
Asn Thr Leu Ser Leu Phe Val Lys Glu Tyr Pro Gly Thr Ser Ile Glu 
545                 550                 555                 560 
Asp Ala Thr Glu Tyr Ile Arg Val Thr Ile Ser Glu Ser Arg Gln Asn 
                565                 570                 575     
Val Leu Met Asn Leu Ile Asn Pro Ser Glu Val Pro Arg Asp Cys Lys 
            580                 585                 590         
Gln Ile Phe Phe Asn Arg Ile Lys Ile Ile Gln Leu Phe Tyr Leu His 
        595                 600                 605             
Ser Asp Glu Phe Thr Ser Pro Thr Ala Lys Leu Asp His Met Gln Ala 
    610                 615                 620                 
Ile Val Tyr Asn Pro Ile Leu 
625                 630     

<210> 51
<211> 631
<212> PRT
<213> Artificial Sequence


<220> 
<223> variant 11

<400> 51
Met Gly Gly Leu Thr Phe Thr Thr Val Ser Thr Thr Ala Asn Tyr Ala 
1               5                   10                  15      
Val Pro Lys Leu Pro Ser Ser Asn Ile Gln Gly Lys Ser Arg Glu Thr 
            20                  25                  30          
Met Phe His Ile Leu Leu Arg Thr Ala Ala Ala Thr Gln Phe Asn Trp 
        35                  40                  45              
Gln Ala Arg Met Lys Phe Gln Pro Lys Thr His Asn Lys Val Met Thr 
    50                  55                  60                  
Leu Ser Val Glu Asp Ser Thr Asn Ile Val Leu Lys Ala Glu Lys Glu 
65                  70                  75                  80  
Asn Arg Glu Asn Lys Ser Phe Gly Ser Met Cys Ile Asp Asp Asn Leu 
                85                  90                  95      
Thr Arg Val Asn Met Leu Tyr Val Asp Ile Lys Met Arg Trp Ser Ser 
            100                 105                 110         
Val Ser Ala Tyr Glu Thr Val His Gly Ala Tyr Pro Leu Asn Val Leu 
        115                 120                 125             
Leu Gly Leu Thr Arg Val Asn His Leu Glu Ser Leu Gly Ile Ala Lys 
    130                 135                 140                 
His Phe Arg Val Glu Ile Arg Glu Ile Leu Asp Asp Val Tyr Arg Trp 
145                 150                 155                 160 
Tyr Leu Asp Asn Asp Arg Val Lys Ala Lys Pro Ser Ala Ser Asp Ile 
                165                 170                 175     
Met Thr Thr Ser Ile Ser Phe Lys Ile Leu Arg Tyr Asn Gly Tyr Asp 
            180                 185                 190         
Val Ser Pro Asp Val Phe Tyr Ser Tyr Leu Arg Asp Ser Glu Phe Leu 
        195                 200                 205             
Pro Phe Ile Asp Asn Ser Gly Asn Ala Ser Met Ala Val Leu Gln Leu 
    210                 215                 220                 
Tyr Lys Ala Ser Gln Met Met Phe Pro Gly Glu Arg Val Leu Glu Glu 
225                 230                 235                 240 
Ala Lys Ser Phe Ser Gln Asn Tyr Leu Asp Asn Ile Lys Val Ala Asp 
                245                 250                 255     
Gln Thr Ala Ala Leu Arg Asp Val Asp Ala Glu Val Met His Gly Leu 
            260                 265                 270         
Asp Val Pro Tyr Met Ala Gly Val Asp Arg Ile Glu His Leu Arg Trp 
        275                 280                 285             
Met Lys Ala Phe Gly Tyr Glu Asp Ile Tyr Val Gly Glu Thr Ser Ser 
    290                 295                 300                 
Met Ile Pro Phe Thr Ala Met Asp Leu Phe Leu Ser Leu Ala Lys Gln 
305                 310                 315                 320 
Asp Phe Asn Ile Cys Gln Glu Gly Gln Gln Glu Asp Leu Lys Ala Leu 
                325                 330                 335     
Glu Met Trp Ser Leu Asp Ser Lys Leu Gly Glu Leu His Phe Ala Arg 
            340                 345                 350         
Asn Met Leu Leu Ala Cys Tyr Phe Ser Ala Gly Ser Thr Leu Trp Ser 
        355                 360                 365             
Pro Glu Met Ser Thr Thr Arg Ile Val Trp Thr Lys Asn Ala Val Leu 
    370                 375                 380                 
Thr Thr Leu Lys Asp Asp Tyr Tyr Asp Ile Glu Gly Ser Val Glu Asp 
385                 390                 395                 400 
Ile Asn Ser Phe Val Glu Ala Leu Arg Arg Trp Asp Pro Leu Ile Val 
                405                 410                 415     
Cys Asn Cys Ser Gly Asn Ile Lys Lys Leu Phe Ser Ala Ile Tyr Asn 
            420                 425                 430         
Ser Leu Asn Glu Leu Ala Gln Glu Ile Trp Leu Phe Gln Gly Trp Glu 
        435                 440                 445             
Ile Ser Thr Asn Ile Met Glu Ile Trp Tyr Glu Leu Ala Ile Ser Met 
    450                 455                 460                 
Met Lys Glu Ala Glu Trp Thr Met Thr Ala Phe Ile Pro Thr Leu Asp 
465                 470                 475                 480 
Glu Tyr Met Glu Asn Gly Arg Ser Ser Ile Ala Leu Glu Pro Ile Ile 
                485                 490                 495     
Phe Thr Ser Ile Trp Tyr Leu Gly Pro Lys Leu Ser Glu Gln Lys Ile 
            500                 505                 510         
His Glu Tyr Met Arg Leu Met Gln Val Val Asn Thr Cys Ala Arg Leu 
        515                 520                 525             
Leu Asn Asp Ser Gln Thr Tyr Met Arg Glu Leu Lys Asn Gly Lys Leu 
    530                 535                 540                 
Asn Ser Leu Ser Leu Phe Val Arg Glu Tyr Pro Gly Thr Ser Ile Glu 
545                 550                 555                 560 
Asp Ala Thr Glu Trp Ile Arg Ile Thr Leu Thr Glu Thr Arg Gln Gln 
                565                 570                 575     
Ile Leu Arg Asn Val Ile Gln Pro Ser Glu Ile Pro Arg Asp Cys Lys 
            580                 585                 590         
Gln Ile Phe Trp Asn Arg Leu Lys Ile Val Gln Leu Phe Tyr Leu His 
        595                 600                 605             
Ser Asp Glu Phe Thr Ser Pro Thr Ala Met Val Glu His Met Gln Ala 
    610                 615                 620                 
Ile Leu Phe Asn Pro Val Ile 
625                 630     

<210> 52
<211> 631
<212> PRT
<213> Artificial Sequence


<220> 
<223> variant 12

<400> 52
Met Ala Gly Ile Ser Tyr Thr Thr Leu Ser Thr Thr Ala Asn Tyr Gly 
1               5                   10                  15      
Val Pro Arg Leu Pro Ser Ser Asn Ile Gln Gly Arg Thr Lys Asp Ser 
            20                  25                  30          
Lys Trp His Val Leu Ile Arg Thr Gly Ala Gly Ser Gln Tyr Asn Tyr 
        35                  40                  45              
Asn Gly Arg Lys Lys Tyr Gln Pro Arg Ser His Asn Lys Val Lys Ser 
    50                  55                  60                  
Leu Ser Val Glu Glu Thr Ser Asn Ile Leu Ile Lys Ala Asp Lys Asp 
65                  70                  75                  80  
Asn Arg Glu Lys Lys Ser Phe Gly Ser Met Cys Ile Asp Glu Asn Ile 
                85                  90                  95      
Ser Lys Ile Asn Met Leu Tyr Leu Glu Ile Lys Arg Lys Tyr Ser Ser 
            100                 105                 110         
Ile Thr Ala Phe Glu Thr Val His Gly Ala Trp Pro Leu Asn Leu Ile 
        115                 120                 125             
Leu Gly Leu Ser Lys Val Asn His Leu Glu Ser Leu Gly Ile Ala Arg 
    130                 135                 140                 
His Phe Arg Leu Glu Ile Lys Glu Val Leu Asp Asp Val Tyr Arg Phe 
145                 150                 155                 160 
Tyr Ile Glu Asn Glu Lys Val Lys Gly Lys Pro Ser Ala Ser Asp Ile 
                165                 170                 175     
Met Thr Ser Ser Ile Ser Phe Lys Ile Leu Arg Trp Asn Gly Tyr Asp 
            180                 185                 190         
Val Ser Pro Asp Val Phe Trp Ser Tyr Val Arg Asp Thr Asp Phe Leu 
        195                 200                 205             
Pro Phe Val Glu Asn Thr Gly Gln Ala Thr Met Ala Val Leu Asn Leu 
    210                 215                 220                 
Tyr Lys Ala Ser Gln Arg Met Tyr Pro Gly Glu Lys Val Leu Glu Glu 
225                 230                 235                 240 
Ala Arg Ser Phe Ser Gln Asn Tyr Leu Glu Asn Val Lys Val Gly Asp 
                245                 250                 255     
Asn Ser Gly Ala Ile Lys Asp Ile Asp Ala Glu Val Arg His Ala Leu 
            260                 265                 270         
Asp Val Pro Trp Arg Ala Ala Leu Glu Arg Val Glu His Leu Arg Tyr 
        275                 280                 285             
Met Lys Ala Phe Gly Phe Glu Glu Leu Trp Leu Gly Glu Thr Ser Ser 
    290                 295                 300                 
Lys Ile Pro Phe Thr Ala Lys Asp Leu Phe Leu Thr Leu Ala Lys Asn 
305                 310                 315                 320 
Asp Phe Asn Ile Cys Gln Glu Ala Gln Gln Asp Asp Leu Met Ala Val 
                325                 330                 335     
Glu Arg Trp Ser Leu Asp Ser Lys Ile Ala Asp Leu His Phe Ala Arg 
            340                 345                 350         
Gln Arg Val Ile Ala Cys Tyr Phe Ser Ala Gly Ser Thr Leu Phe Ser 
        355                 360                 365             
Pro Glu Lys Ser Thr Thr Arg Leu Val Tyr Thr Lys Asn Ala Val Leu 
    370                 375                 380                 
Thr Thr Leu Met Asp Asp Trp Tyr Asp Val Glu Gly Ser Leu Glu Asp 
385                 390                 395                 400 
Ile Gln Ser Phe Val Asp Ala Val Lys Arg Trp Asp Pro Ile Val Val 
                405                 410                 415     
Cys Asn Cys Ser Ala Asn Leu Lys Met Val Phe Ser Ala Ile Phe Asn 
            420                 425                 430         
Thr Val Asn Asp Leu Ala Gln Glu Val Phe Val Phe Asn Ala Trp Asp 
        435                 440                 445             
Leu Ser Thr Asn Leu Arg Asp Leu Trp Tyr Asp Val Ala Ile Ser Met 
    450                 455                 460                 
Met Arg Glu Ala Glu Trp Thr Lys Thr Gly Trp Leu Pro Thr Ile Glu 
465                 470                 475                 480 
Glu Tyr Met Glu Asn Gly Lys Thr Ser Ile Ala Leu Glu Pro Ile Ile 
                485                 490                 495     
Phe Thr Thr Val Phe Phe Leu Gly Pro Met Ile Thr Glu Gln Met Val 
            500                 505                 510         
His Asp Trp Arg Arg Leu Lys Gln Leu Leu Asn Thr Cys Gly Arg Leu 
        515                 520                 525             
Ile Asn Asp Ser Asn Ser Phe Lys Met Glu Leu Lys Asn Gly Lys Val 
    530                 535                 540                 
Asn Ser Val Ser Leu Phe Val Lys Glu Trp Pro Ala Thr Ser Ile Glu 
545                 550                 555                 560 
Asp Ala Ser Glu Tyr Ile Lys Val Thr Leu Ser Glu Ser Arg Gln Asn 
                565                 570                 575     
Ile Leu Lys Gln Leu Val Gln Pro Ser Glu Ile Pro Lys Glu Cys Lys 
            580                 585                 590         
Gln Ile Phe Trp Asn Lys Val Lys Leu Leu Gln Val Phe Tyr Leu His 
        595                 600                 605             
Ser Asp Asp Phe Thr Thr Pro Thr Gly Met Leu Glu His Met Gln Gly 
    610                 615                 620                 
Val Val Phe Asn Pro Val Val 
625                 630     

<210> 53
<211> 631
<212> PRT
<213> Artificial Sequence


<220> 
<223> variant 13

<400> 53
Met Ala Ala Val Ser Phe Thr Thr Leu Thr Thr Ser Gly Asn Trp Ala 
1               5                   10                  15      
Leu Pro Lys Val Pro Ser Ser Gln Leu Gln Gly Arg Ser Met Glu Thr 
            20                  25                  30          
Arg Trp His Leu Leu Ile Met Ser Ala Gly Ala Thr Gln Tyr Asn Phe 
        35                  40                  45              
Asn Gly Met Met Lys Phe Gln Pro Arg Thr His Gln Lys Ile Arg Ser 
    50                  55                  60                  
Leu Ser Val Asp Asp Ser Thr Asn Val Val Val Met Ala Glu Arg Asp 
65                  70                  75                  80  
Asn Arg Glu Asn Lys Ser Phe Gly Ser Met Cys Ile Glu Asp Gln Ile 
                85                  90                  95      
Thr Arg Ile Asn Lys Leu Tyr Leu Asp Ile Arg Met Lys Phe Thr Ser 
            100                 105                 110         
Leu Ser Ala Tyr Asp Thr Val His Gly Gly Phe Pro Val Asn Leu Ile 
        115                 120                 125             
Ile Gly Leu Ser Arg Val Asn His Leu Glu Ser Leu Gly Ile Gly Arg 
    130                 135                 140                 
His Phe Lys Ile Glu Ile Lys Glu Leu Leu Glu Asp Val Phe Met Phe 
145                 150                 155                 160 
Phe Leu Glu Asn Glu Met Val Arg Ala Lys Pro Thr Ala Ser Asp Ile 
                165                 170                 175     
Lys Thr Ser Ser Ile Ser Phe Lys Ile Leu Arg Tyr Asn Gly Tyr Asp 
            180                 185                 190         
Val Ser Pro Asp Val Phe Phe Ser Tyr Val Lys Asp Thr Asp Phe Val 
        195                 200                 205             
Pro Trp Leu Glu Asn Thr Gly Gln Ala Thr Lys Ala Ile Leu Gln Leu 
    210                 215                 220                 
Tyr Lys Ala Ser Gln Met Lys Trp Pro Gly Glu Arg Ile Leu Glu Glu 
225                 230                 235                 240 
Ala Lys Thr Phe Ser Gln Asn Tyr Leu Glu Asn Leu Lys Ile Gly Asp 
                245                 250                 255     
Gln Ser Gly Ala Leu Met Glu Ile Glu Ala Asp Val Met His Ala Leu 
            260                 265                 270         
Asp Val Pro Trp Met Ala Gly Val Glu Arg Val Glu His Leu Arg Phe 
        275                 280                 285             
Met Met Ala Phe Ala Phe Asp Glu Val Tyr Val Gly Glu Thr Ser Ser 
    290                 295                 300                 
Met Val Pro Phe Thr Gly Arg Asp Ile Phe Leu Ser Leu Ala Lys Gln 
305                 310                 315                 320 
Asp Phe Asn Ile Cys Gln Glu Ala Gln Gln Glu Asp Leu Lys Gly Leu 
                325                 330                 335     
Glu Lys Trp Ser Val Asp Ser Met Val Gly Asp Leu His Phe Gly Arg 
            340                 345                 350         
Gln Arg Leu Val Ala Cys Tyr Phe Ser Ala Ala Ser Thr Val Trp Ser 
        355                 360                 365             
Pro Glu Arg Ser Thr Thr Arg Ile Val Trp Thr Lys Asn Ala Val Ile 
    370                 375                 380                 
Thr Thr Val Met Asp Asp Phe Tyr Asp Val Glu Gly Ser Ile Glu Asp 
385                 390                 395                 400 
Ile Asn Ser Phe Ile Asp Ala Val Lys Arg Trp Asp Pro Leu Val Leu 
                405                 410                 415     
Cys Asn Cys Ser Ala Asn Leu Lys Lys Leu Phe Ser Ala Ile Tyr Asn 
            420                 425                 430         
Ser Val Gln Asp Ile Gly Gln Glu Ile Phe Val Trp Gln Gly Phe Asp 
        435                 440                 445             
Ile Ser Thr Asn Leu Arg Glu Ile Tyr Trp Glu Leu Gly Ile Thr Met 
    450                 455                 460                 
Lys Lys Glu Ala Asp Trp Thr Met Ser Gly Tyr Leu Pro Thr Ile Glu 
465                 470                 475                 480 
Glu Tyr Met Glu Asn Gly Arg Thr Ser Ile Ala Leu Glu Pro Ile Ile 
                485                 490                 495     
Phe Ser Ser Leu Phe Trp Val Gly Pro Lys Leu Thr Glu Asn Met Ile 
            500                 505                 510         
His Glu Tyr Met Lys Ile Arg Gln Ile Ile Gln Thr Cys Gly Arg Leu 
        515                 520                 525             
Ile Asn Asp Ser Gln Ser Tyr Lys Lys Glu Val Lys Gln Gly Lys Leu 
    530                 535                 540                 
Gln Ser Leu Ser Leu Phe Val Arg Glu Tyr Pro Gly Ser Ser Leu Glu 
545                 550                 555                 560 
Asp Ala Thr Glu Phe Ile Met Val Ser Leu Ser Glu Thr Arg Gln Asn 
                565                 570                 575     
Val Leu Arg Asn Leu Leu Gln Pro Ser Glu Val Pro Arg Glu Cys Lys 
            580                 585                 590         
Gln Ile Tyr Phe Asn Lys Val Lys Leu Leu Asn Val Tyr Tyr Leu His 
        595                 600                 605             
Ser Asp Glu Tyr Ser Ser Pro Thr Ala Arg Ile Glu His Met Asn Ala 
    610                 615                 620                 
Val Ile Trp Asn Pro Val Val 
625                 630     

<210> 54
<211> 631
<212> PRT
<213> Artificial Sequence


<220> 
<223> variant 14

<400> 54
Met Gly Gly Ile Ser Tyr Ser Thr Val Thr Thr Thr Ala Gln Tyr Gly 
1               5                   10                  15      
Ile Pro Met Leu Pro Ser Thr Gln Val Asn Ala Met Ser Lys Asp Thr 
            20                  25                  30          
Lys Tyr His Val Leu Ile Lys Thr Ala Gly Ala Ser Asn Trp Asn Phe 
        35                  40                  45              
Asn Gly Met Arg Lys Tyr Asn Pro Arg Thr His Gln Lys Val Lys Thr 
    50                  55                  60                  
Val Ser Val Glu Asp Thr Ser Gln Val Leu Ile Lys Gly Asp Lys Glu 
65                  70                  75                  80  
Asn Arg Glu Lys Lys Ser Phe Gly Ser Met Cys Ile Asp Asp Asn Ile 
                85                  90                  95      
Thr Lys Ile Asn Met Leu Phe Val Asp Ile Lys Lys Arg Trp Thr Ser 
            100                 105                 110         
Val Ser Ala Tyr Asp Thr Val His Gly Ala Trp Pro Ile Asn Leu Ile 
        115                 120                 125             
Ile Gly Leu Ser Lys Val Asn His Leu Glu Ser Leu Gly Ile Ala Met 
    130                 135                 140                 
His Phe Arg Val Glu Ile Met Asp Val Leu Asp Asp Val Phe Lys Tyr 
145                 150                 155                 160 
Tyr Ile Asp Asn Glu Met Val Arg Ala Met Pro Ser Ala Thr Asp Ile 
                165                 170                 175     
Met Ser Ser Ser Ile Ser Phe Lys Ile Leu Arg Trp Gln Gly Tyr Asp 
            180                 185                 190         
Val Ser Pro Asp Ile Phe Phe Ser Tyr Leu Lys Glu Ser Glu Phe Leu 
        195                 200                 205             
Pro Trp Ile Asp Gln Ser Gly Gln Ala Thr Arg Ala Leu Leu Asn Leu 
    210                 215                 220                 
Tyr Lys Ala Ser Asn Met Met Phe Pro Gly Glu Arg Ile Leu Glu Glu 
225                 230                 235                 240 
Ala Lys Thr Phe Ser Asn Asn Trp Leu Glu Asn Ile Lys Val Gly Asp 
                245                 250                 255     
Gln Ser Ala Ala Leu Lys Asp Val Asp Ala Glu Val Met His Gly Leu 
            260                 265                 270         
Asp Leu Pro Tyr Met Ala Gly Val Asp Arg Ile Glu His Leu Arg Phe 
        275                 280                 285             
Met Arg Ala Phe Gly Phe Asp Asp Ile Trp Val Gly Glu Thr Thr Ser 
    290                 295                 300                 
Arg Ile Pro Trp Thr Gly Lys Asp Ile Phe Leu Ser Leu Ala Lys Gln 
305                 310                 315                 320 
Asp Phe Asn Ile Cys Gln Glu Gly Gln Gln Glu Asp Leu Met Gly Ile 
                325                 330                 335     
Asp Lys Trp Ser Val Asp Ser Lys Leu Gly Glu Leu His Phe Ala Arg 
            340                 345                 350         
Gln Arg Leu Val Ala Cys Tyr Trp Ser Ala Ala Ser Ser Leu Trp Ser 
        355                 360                 365             
Pro Asp Lys Thr Thr Thr Arg Ile Val Tyr Thr Lys Gln Ala Ile Leu 
    370                 375                 380                 
Thr Ser Val Lys Asp Asp Trp Tyr Asp Ile Asp Gly Ser Ile Glu Asp 
385                 390                 395                 400 
Ile Gln Ser Phe Ile Glu Ala Val Lys Arg Trp Asp Pro Ile Leu Leu 
                405                 410                 415     
Cys Asn Cys Ser Ala Asn Ile Lys Met Leu Phe Ser Ala Ile Trp Gln 
            420                 425                 430         
Ser Ile Asn Asp Ile Gly Gln Glu Leu Trp Leu Tyr Asn Gly Tyr Asp 
        435                 440                 445             
Ile Ser Thr Gln Val Arg Asp Ile Phe Tyr Glu Leu Gly Ile Ser Lys 
    450                 455                 460                 
Met Lys Glu Ala Glu Trp Thr Lys Ser Gly Phe Ile Pro Ser Leu Glu 
465                 470                 475                 480 
Glu Tyr Met Glu Asn Gly Arg Thr Ser Ile Ala Leu Glu Pro Ile Ile 
                485                 490                 495     
Trp Thr Ser Leu Phe Phe Leu Gly Pro Lys Leu Ser Glu Gln Met Leu 
            500                 505                 510         
His Asp Tyr Arg Lys Leu Met Gln Val Leu Asn Ser Cys Ala Arg Leu 
        515                 520                 525             
Leu Asn Asp Ser Gln Ser Trp Met Arg Glu Val Lys Gln Gly Met Ile 
    530                 535                 540                 
Asn Ser Leu Ser Leu Phe Val Lys Asp Trp Pro Gly Thr Ser Leu Glu 
545                 550                 555                 560 
Asp Ala Thr Asp Phe Ile Lys Leu Thr Leu Ser Glu Ser Arg Gln Asn 
                565                 570                 575     
Ile Leu Lys Asn Leu Val Asn Pro Ser Glu Ile Pro Arg Asp Cys Lys 
            580                 585                 590         
Gln Val Trp Phe Asn Arg Ile Lys Val Val Gln Val Phe Tyr Ile His 
        595                 600                 605             
Thr Asp Glu Phe Thr Ser Pro Ser Ala Lys Leu Asp His Met Gln Gly 
    610                 615                 620                 
Leu Val Trp Asn Pro Val Ile 
625                 630     

<210> 55
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cup motif

<400> 55
Glu Asn Asn Ser Phe Gly Ser Met Cys Ile 
1               5                   10  

<210> 56
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cup motif

<400> 56
Glu Lys Lys Ser Phe Gly Ser Met Cys Ile 
1               5                   10  

<210> 57
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cup motif

<400> 57
Glu Lys Asn Ser Phe Gly Ser Met Cys Ile 
1               5                   10  

<210> 58
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cup motif

<400> 58
Glu Asn Lys Ser Phe Gly Ser Met Cys Ile 
1               5                   10  

