                         SEQUENCE LISTING

<110>  Institut national de recherche pour l'agriculture,
       l'alimentation et l'environnement
       Institut des sciences et industries du vivant et de
       l'environnement
 
<120>  GENETICALLY MODIFIED BACTERIA AND USES THEREOF FOR THE INDUCIBLE 
       EXPRESSION OF A NUCLEIC SEQUENCE OF INTEREST

<130>  PAT2603559PC00

<150>  EP21305953
<151>  2021-07-09

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  DNA
<213>  Streptococcus thermophilus


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  W = A or T

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  K = T or G

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  W = A or T

<400>  1
gcawatakgg gaatw                                                        15


<210>  2
<211>  18
<212>  DNA
<213>  Streptococcus thermophilus


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  K = G or T

<400>  2
aattgcktat aagggaaa                                                     18


<210>  3
<211>  19
<212>  DNA
<213>  Streptococcus thermophilus

<400>  3
atttcatatc ttcaatttt                                                    19


<210>  4
<211>  285
<212>  PRT
<213>  Streptococcus thermophilus

<400>  4

Met Lys Asp Tyr Gly Lys Leu Phe Lys Lys Phe Arg Glu Ser Arg Gly 
1               5                   10                  15      


Leu Val Leu Lys Asp Ile Ala Lys Leu Gly Val Ser Val Ser His Ile 
            20                  25                  30          


Ser Arg Phe Glu Arg Glu Asn Thr Asp Leu Thr Ile Ser Lys Phe Met 
        35                  40                  45              


Ser Ala Leu Asn Ala Ile Asn Met Pro Ile Asp Glu Phe Met Tyr Ala 
    50                  55                  60                  


Ala Asn Asp Phe Gln Arg Asp Glu Phe Asn Glu Ile Leu Glu Lys Ile 
65                  70                  75                  80  


Ser Leu Phe Val Ser Ala Arg Asn Val Ser Gly Met Glu Lys Leu Leu 
                85                  90                  95      


Ile Ser Gln Val Glu Lys Ile Glu Lys Arg Glu Thr Phe Tyr Thr Leu 
            100                 105                 110         


Asn Thr Ile Leu Ile Lys Ile Arg Leu Gln Asp Leu Ser Asp Lys Ser 
        115                 120                 125             


Tyr Tyr Asp Glu Ser Asp Ile Gln Tyr Leu Ser Asp Tyr Leu Phe Ser 
    130                 135                 140                 


Val Glu Tyr Trp Gly Cys Tyr Glu Leu Leu Leu Phe Ala Asn Thr Val 
145                 150                 155                 160 


Asp Val Leu Asn His Gln Thr Met Met Leu Leu Ser Arg Glu Met Cys 
                165                 170                 175     


Lys Arg Ser Glu Phe Tyr Lys Asp Leu Pro Asn Tyr Arg Arg Leu His 
            180                 185                 190         


Ser Thr Met Leu Leu Asn Cys Tyr Ile Ile Ser Ile Glu Arg Asp Glu 
        195                 200                 205             


Tyr Ile Asp Ala Leu Tyr Phe Glu Lys Gln Leu Asn His Ser Cys Phe 
    210                 215                 220                 


Thr Glu Thr Glu Ile Tyr Glu Lys Leu Val Phe His Tyr Ser Lys Asn 
225                 230                 235                 240 


Leu Tyr Glu Leu Lys Lys Asn Arg Ser Asn Lys Ala Ile Leu Glu Met 
                245                 250                 255     


Lys Lys Cys Ile Thr Ala Met Lys Leu Ala Asn Ser Glu Asn Leu Ala 
            260                 265                 270         


Ile Lys Phe Glu Asn His Leu Ser Gly Val Leu Lys Met 
        275                 280                 285 


<210>  5
<211>  291
<212>  PRT
<213>  Streptococcus thermophilus

<400>  5

Met Asp Ser Asn Glu Leu Leu Lys Leu Gly Glu Phe Tyr Lys Glu Leu 
1               5                   10                  15      


Arg Ile Ala Arg Lys Val Lys Gln Lys Asp Val Ala Lys Asn Lys Leu 
            20                  25                  30          


Ser Val Ser Gln Leu Ser Lys Phe Glu Ser Gly Gln Thr Met Leu Ser 
        35                  40                  45              


Ala Asp Lys Met Leu Glu Val Ile Glu Gly Ile Asn Leu Thr Phe Ser 
    50                  55                  60                  


Glu Phe Gly Phe Ala Leu Arg Asp Tyr Lys Pro Thr Gln His Gln Leu 
65                  70                  75                  80  


Leu Met Asn Lys Ile Ser Lys Leu Ser Ala Glu Asn Asp Lys Gln Ser 
                85                  90                  95      


Leu Leu Lys Leu Leu Asp Lys Tyr Lys Glu Ser Gln Leu Leu Tyr Asp 
            100                 105                 110         


Lys Leu Asn Thr Leu Val Ile Lys Asn Ala Ile His Leu Ile Asp Arg 
        115                 120                 125             


Asp Phe Thr Leu Ser Leu Asp Asp Ser Lys Phe Leu Ser Asn Tyr Leu 
    130                 135                 140                 


Phe Asp Ile Glu Asp Trp Thr Ala Tyr Glu Ile His Leu Phe Gly Asn 
145                 150                 155                 160 


Thr Met Pro Phe Leu Ser Asp Thr Asp Leu Leu Phe Leu Gly Lys Glu 
                165                 170                 175     


Leu Val Ser Arg Ser Glu Ile Tyr Ser Pro Leu Leu Asp Phe Arg Lys 
            180                 185                 190         


Ala Leu Lys Tyr Thr Tyr Leu Asn Leu Ile Ser Glu Leu Val Glu Arg 
        195                 200                 205             


Arg Leu Thr Thr His Phe Asn Phe Phe Val Asn Gln Leu Arg Met Ile 
    210                 215                 220                 


Leu Asp Val Phe Asp Thr Phe Glu Ile Ile Leu Leu Asn Phe Leu Val 
225                 230                 235                 240 


Leu Val Tyr Ser Tyr Leu Ile Glu Asn Ser Val Asn Leu Glu Glu Val 
                245                 250                 255     


Glu Gln Tyr Ile Leu Lys Val Ser Glu Ile Glu Gln Leu Gly Leu Ser 
            260                 265                 270         


Lys Ile Leu Glu Gln Arg Leu Ser Gln Tyr Leu Arg Thr Asn Gln Lys 
        275                 280                 285             


Gly Glu Arg 
    290     


<210>  6
<211>  286
<212>  PRT
<213>  Streptococcus thermophilus

<400>  6

Met Lys Lys Phe Gly Glu Ile Phe Lys Lys Phe Arg Glu Ser Arg Gly 
1               5                   10                  15      


Leu Arg Leu Lys Asp Val Ala Lys Ala Gly Ile Ser Thr Ser Gln Leu 
            20                  25                  30          


Ser Arg Phe Glu Lys Gly Glu Thr Asp Leu Thr Ile Ser Lys Phe Met 
        35                  40                  45              


Phe Ile Leu Asp Glu Ile Asn Met Pro Ile Asp Glu Phe Met Tyr Ala 
    50                  55                  60                  


Val His Asp Phe His Arg Asp Glu Leu Asn Glu Leu Leu Ser Lys Val 
65                  70                  75                  80  


Arg His Phe Val Ser Thr Arg Asp Val Glu Gly Met Lys Lys Leu Leu 
                85                  90                  95      


Tyr Ser Gln Met Glu Leu Glu Asp Arg Arg Glu Lys Phe His Gln Ile 
            100                 105                 110         


Asn Ile Ile Leu Leu Lys Ile Arg Leu Gln Asp Leu Ser Gly Glu Thr 
        115                 120                 125             


Tyr Tyr Thr Lys Asp Asp Leu Thr Tyr Leu Thr Asp Tyr Leu Phe Ser 
    130                 135                 140                 


Val Glu Tyr Trp Gly Tyr Tyr Glu Leu Leu Ile Phe Ser Asn Thr Leu 
145                 150                 155                 160 


Asp Val Leu Asn His Asp Val Phe Met Val Leu Ala Arg Glu Met Phe 
                165                 170                 175     


Arg Arg Ser Asp Phe Tyr Lys Glu Ile Pro Asn Asn Arg Arg Leu Ile 
            180                 185                 190         


Ser Thr Met Leu Leu Asn Gly Tyr Ile Thr Cys Val Glu Arg Glu Lys 
        195                 200                 205             


Phe Met Asp Ala Leu Tyr Phe Glu Lys Gln Leu Asn Gln Cys Phe Phe 
    210                 215                 220                 


Ile Glu Thr Glu Val Tyr Glu Arg Leu Val Phe Lys Tyr Ala Gln Asn 
225                 230                 235                 240 


Leu Tyr Gln Tyr Lys Glu Asp Gly Asn Val Lys Ala Ile Ile Glu Met 
                245                 250                 255     


Lys Lys Cys Val Gly Ala Met Lys Leu Ala Gly Ser His His Leu Ala 
            260                 265                 270         


Lys Thr Tyr Glu Gly His Leu Glu Lys Ile Leu Ala Ser Ser 
        275                 280                 285     


<210>  7
<211>  287
<212>  PRT
<213>  Streptococcus thermophilus

<400>  7

Met Lys Glu Phe Gly Ala Ile Phe Lys Lys Phe Arg Lys Ser Arg Gly 
1               5                   10                  15      


Ile Arg Leu Lys Asp Val Ala Lys Ala Gly Ile Ser Thr Ser Gln Leu 
            20                  25                  30          


Ser Arg Phe Glu Lys Gly Gln Thr Asp Leu Thr Ile Thr Lys Phe Met 
        35                  40                  45              


Leu Ile Leu Asp Glu Ile Asn Met Pro Ile Asp Glu Phe Met Tyr Ala 
    50                  55                  60                  


Val His Asp Phe His Arg Asp Asp Leu Asn Glu Leu Leu Ser Lys Ile 
65                  70                  75                  80  


Arg Leu Phe Val Ser Thr His Asp Ile Asp Gly Leu Lys Lys Leu Leu 
                85                  90                  95      


Ser Ser Gln Leu Glu Ser Glu Pro Lys Arg Glu Lys Phe His His Ile 
            100                 105                 110         


Asn Thr Ile Leu Leu Lys Ile Arg Leu Gln Asp Leu Ser Gly Glu Ser 
        115                 120                 125             


Tyr Tyr Thr Gln Gln Asp Leu Ala Asp Leu Thr Asp Tyr Leu Phe Ser 
    130                 135                 140                 


Val Glu Tyr Trp Gly Tyr Tyr Glu Leu Leu Ile Phe Ala Asn Thr Leu 
145                 150                 155                 160 


Asp Val Leu Asn His Glu Thr Leu Met Val Leu Ala Lys Glu Met Ser 
                165                 170                 175     


Arg Arg Ser Asp Phe Tyr Lys Glu Ile Pro Asn Asn Arg Arg Met Ile 
            180                 185                 190         


Ser Thr Met Leu Leu Asn Val Tyr Ile Thr Cys Ile Glu Arg Glu Glu 
        195                 200                 205             


Leu Ile Asp Ala Leu Tyr Phe Glu Lys Gln Leu Asn Gln Cys Phe Phe 
    210                 215                 220                 


Ile Glu Thr Glu Ile Tyr Glu Arg Leu Val Phe Gln Tyr Ala Gln Asn 
225                 230                 235                 240 


Tyr Tyr Gln Tyr Lys Lys Glu Gly Asn Asn Gln Ser Ile Ile Glu Met 
                245                 250                 255     


Lys Lys Tyr Ile Gly Ala Met Lys Leu Ala Gly Ser Glu His Ile Ala 
            260                 265                 270         


Lys Thr Tyr Glu Ala His Leu Lys Lys Leu Ile Glu Glu Asn Ser 
        275                 280                 285         


<210>  8
<211>  232
<212>  PRT
<213>  Streptococcus thermophilus

<400>  8

Met Pro Ile Glu Glu Phe Val Tyr Ala Val Arg Asp Phe Arg Arg Asp 
1               5                   10                  15      


Asp Phe Asn Glu Leu Leu Glu Lys Ile Arg Tyr Leu Val Ser Asn Arg 
            20                  25                  30          


Asp Ile Asp Gly Met Lys Lys Leu Leu Ile Ser Gln Met Glu Lys Lys 
        35                  40                  45              


Asp Lys Lys Glu Pro Phe Ala Ser Phe Asn Thr Ile Leu Ile Lys Ile 
    50                  55                  60                  


Arg Leu Gln Asp Leu Ser Gly Glu Thr Tyr Val Thr Asp Gln Glu Ile 
65                  70                  75                  80  


Val Thr Ile Ser Asp Tyr Leu Phe Ser Ala Glu Tyr Trp Gly Tyr Tyr 
                85                  90                  95      


Glu Leu Leu Leu Phe Met Asn Thr Ile Asp Ala Leu Asn His Asn Thr 
            100                 105                 110         


Met Met Ile Leu Ala Lys Glu Met Cys His Arg Leu Asp Phe Tyr Arg 
        115                 120                 125             


Asp Ile Pro Asn Asn Arg Arg Leu Leu Ala Thr Met Leu Leu Asn Ala 
    130                 135                 140                 


Tyr Ile Thr Cys Ile Glu Arg Asn Glu Trp Met Asp Ala Leu Tyr Phe 
145                 150                 155                 160 


Glu Lys Gln Leu Lys Tyr Cys Asn Phe Ser Glu Thr Glu Met Tyr Glu 
                165                 170                 175     


Lys Leu Val Leu His Tyr Ala Asn Asn Leu Tyr Asp Leu Lys Lys Asn 
            180                 185                 190         


Asn Asn Arg His Ala Val Leu Glu Met Arg Lys Cys Ile Ala Ala Thr 
        195                 200                 205             


Lys Leu Val Asp Ser Asn Gln Ile Ser Ile Lys Phe Glu Asn Tyr Leu 
    210                 215                 220                 


Gln Lys Val Leu Asp Asp Met Arg 
225                 230         


<210>  9
<211>  238
<212>  PRT
<213>  Streptococcus thermophilus

<400>  9

Met Ile Lys Phe Leu Ser Ala Leu Asp Phe Ile Asn Val Ser Ile Glu 
1               5                   10                  15      


Glu Phe Met Val Ile Tyr Arg Gly Tyr Arg Asn Asp Ser Phe Glu Glu 
            20                  25                  30          


Leu Leu Lys Lys Leu His Thr Leu Ser Leu Thr Lys Asp Ala Glu Gly 
        35                  40                  45              


Leu Arg Tyr Leu Phe Asn Glu Val Glu Glu Leu Pro Asn Ser Thr Thr 
    50                  55                  60                  


Lys Lys Ile Glu Lys Ile Leu Ile Leu Ser Cys Leu Ser Ser Val Glu 
65                  70                  75                  80  


Ser Glu Asn Leu Ile Thr Gln Ser Asp Leu Arg Phe Val Thr Asp Tyr 
                85                  90                  95      


Leu Phe Gly Ile Glu Ser Trp Gly Tyr Tyr Glu Leu Ser Ile Leu Gly 
            100                 105                 110         


Asn Leu Ala Gln Tyr Ile Asn Gly Glu Thr Leu Val Ser Leu Gly Arg 
        115                 120                 125             


Glu Val Leu Arg Lys Thr Asp Tyr Tyr Tyr Glu Val Val Arg Asn Arg 
    130                 135                 140                 


Lys Leu Val Ile Gln Leu Ser Ile Asn Ile Met Ile Arg Cys Ile Glu 
145                 150                 155                 160 


Ser Glu Trp Phe Thr Lys Ala Ala Phe Phe Glu Arg His Ile Asp Ser 
                165                 170                 175     


Leu Val Asn Val Glu Ser Asp Met Tyr Glu Lys Val Ile Phe Ser Tyr 
            180                 185                 190         


Val Gln Gly Tyr Leu Lys Phe Ala Met Gly Asp Ser Gly Gly Lys Gln 
        195                 200                 205             


Ile Met Gln Glu Ser Leu Glu Ile Phe Lys Leu Leu Lys Asn Thr Arg 
    210                 215                 220                 


Leu Tyr Lys Asn Tyr Leu Glu His Phe Lys Ser Ile Val Gly 
225                 230                 235             


<210>  10
<211>  284
<212>  PRT
<213>  Streptococcus thermophilus

<400>  10

Met Lys Ser Lys Leu Gly Ser Thr Leu Arg Lys Val Arg Asn Gly Lys 
1               5                   10                  15      


Gln Ile Ser Ile Cys Ser Val Ala Asp Glu His Leu Ser Lys Ser Gln 
            20                  25                  30          


Ile Ser Arg Phe Glu Arg Gly Glu Ser Glu Ile Ser Cys Ile Arg Leu 
        35                  40                  45              


Ile Asn Ile Leu Asp Lys Leu His Ile Thr Leu Asp Glu Phe Leu Ile 
    50                  55                  60                  


Leu His Asp Glu Asp Tyr Thr Lys Thr Glu Ser Phe Ala Asn Leu Val 
65                  70                  75                  80  


Gln Tyr Ile Arg Lys Gln Tyr Ser Leu Gln Asn Ile Asn Asn Ile Gln 
                85                  90                  95      


Ser Leu Leu Ser Asp Ser Ser Asn Tyr Thr Leu Asp Pro Phe Glu Lys 
            100                 105                 110         


Thr Met Val Lys Ser Ile Leu His Thr Met Asp Ser Ser Ile Ile Pro 
        115                 120                 125             


Ser Asp Asp Glu Leu Leu Gln Leu Ala Asp Tyr Leu Phe Lys Val Glu 
    130                 135                 140                 


Lys Trp Gly Tyr Tyr Glu Ile Ile Leu Leu Gly Asn Cys Val Arg Thr 
145                 150                 155                 160 


Ile Asp Tyr Asn Ser Val Phe Leu Leu Thr Lys Glu Met Leu Asn Asn 
                165                 170                 175     


Tyr Ile Tyr Ser Ser Leu Asn Lys Thr Asn Lys Arg Ile Val Thr Gln 
            180                 185                 190         


Leu Ala Ile Asn Cys Leu Ile Leu Ser Ile Asp Met Glu Glu Phe Thr 
        195                 200                 205             


Asn Cys Phe Tyr Leu Ile Asp Glu Ile Lys Ala Leu Leu Asp Asn Glu 
    210                 215                 220                 


Leu Asn Phe Tyr Glu Gln Thr Val Phe Leu Tyr Ala Thr Gly Tyr Phe 
225                 230                 235                 240 


Glu Phe Lys Arg Trp Gln Ser Thr Ser Gly Ile Glu Lys Met Lys Gln 
                245                 250                 255     


Ala Ile Gln Val Leu Asp Ile Leu Gly Glu Asp Asn Leu Lys Leu His 
            260                 265                 270         


Tyr Thr Ile His Phe Asp Lys Leu Ile Asn Asn Lys 
        275                 280                 


<210>  11
<211>  287
<212>  PRT
<213>  Streptococcus thermophilus

<400>  11

Met Asn Ile Gln Glu Lys Phe Lys Ala Ile Arg Lys Gln Arg Lys Leu 
1               5                   10                  15      


Ser Leu Arg Asp Leu Ala Asn Val Ala Gly Ser Thr Ser Ser Ile Ser 
            20                  25                  30          


Asp Phe Glu Lys Gly Lys Thr Asn Leu Ser Asn Asp Val Leu Leu Gln 
        35                  40                  45              


Leu Leu Gly Phe Met Val Val Glu Ile Asn Glu Ile Phe Glu Trp Ser 
    50                  55                  60                  


Ala Phe Gln Asp Ala Glu Phe Leu Glu Leu Met Thr Gln Val Glu Asn 
65                  70                  75                  80  


Ala Leu Gln Thr Gln Asp Ile Thr Val Leu Ile Gln Lys Arg Glu Thr 
                85                  90                  95      


Leu Gln Glu Phe Phe Val Ala Lys Asn His Tyr Ile Tyr His Ile Ile 
            100                 105                 110         


Ser Leu Val Leu Asp Val Ile Ile Ser Lys Leu Gln Glu Lys Glu Pro 
        115                 120                 125             


Thr Pro Glu Ile Ile Ser Glu Leu Thr Asp Tyr Phe Phe Ser Leu Asp 
    130                 135                 140                 


Tyr Trp Thr Asn Leu Asp Val Gly Leu Leu Gly Asn Ile Val His His 
145                 150                 155                 160 


Phe Thr Thr Glu Thr Leu Val Leu Phe Thr Asp Ser Ile Leu Lys Asn 
                165                 170                 175     


Thr Pro Asn Gln Leu Arg Asn Asn Leu Asp Arg Ile Lys Ile Asp Thr 
            180                 185                 190         


Val Ile Asn Cys Leu Ser Val Leu Leu Ala Arg Arg Glu Lys Asn Ala 
        195                 200                 205             


Ser Gln Glu Leu Leu Gln Leu Leu Ser Arg Lys Gln Phe Pro Thr Tyr 
    210                 215                 220                 


Phe Thr Tyr Glu Lys Leu Cys Ile Ser Glu Phe Lys Ala Ile Tyr Met 
225                 230                 235                 240 


Tyr Ile Trp Cys Asp Lys Glu Glu Ala Asp Asn Ile His Gln Thr Ile 
                245                 250                 255     


Leu Lys Thr Val Ser Leu Leu Phe Thr Lys Asp Glu Ala Asn Lys Trp 
            260                 265                 270         


Asp Asp Tyr Phe Lys Glu Ile Ile Ser Ser Ala Asp Ile Lys Lys 
        275                 280                 285         


<210>  12
<211>  286
<212>  PRT
<213>  Streptococcus thermophilus

<400>  12

Met Asn Thr Asn Glu Ser Met Asp Leu Gly Glu Leu Phe Arg Glu Leu 
1               5                   10                  15      


Arg Ile Ala Arg Gly Leu Lys Leu Lys Asp Val Ala Ser Asp Lys Leu 
            20                  25                  30          


Ser Val Ser Gln Leu Ser Lys Phe Glu Asn Gly Gln Thr Met Leu Ser 
        35                  40                  45              


Ser Asp Lys Leu Leu Val Ala Ile Ser Gly Ile His Met Asn Phe Ser 
    50                  55                  60                  


Glu Phe Gly Tyr Ala Leu Asn Asn Tyr Gln Glu Pro Glu Phe Phe Lys 
65                  70                  75                  80  


Leu Gly Glu Lys Ile Ala Ala Leu His Ser Lys Gln Asp Ile Asp Gly 
                85                  90                  95      


Leu Lys Lys Leu Leu Val Thr Tyr Lys Gly Cys Glu Ser Phe Asp Val 
            100                 105                 110         


Tyr Asn Arg Leu Asn Leu Leu Val Ile Lys Val Ala Ile His Ser Leu 
        115                 120                 125             


Asp Asn Ser Ser Leu Ile Thr Asp Glu Asp Lys Glu Phe Leu Thr Asn 
    130                 135                 140                 


Tyr Leu Tyr Glu Ile Glu Ala Trp Thr Glu Tyr Glu Leu Tyr Ile Phe 
145                 150                 155                 160 


Gly Asn Thr Met Ser Ile Leu Ser Asp Ser Asp Leu Ile Phe Leu Gly 
                165                 170                 175     


Lys Ala Phe Glu Glu Arg Ser Lys Leu Tyr Ser Ser Leu Thr Ser His 
            180                 185                 190         


Lys Lys Ser Ala Glu Ile Ala Phe Leu Asn Leu Ile Leu Ile Leu Ile 
        195                 200                 205             


Glu Arg Lys Glu Ile Tyr Tyr Val Arg Tyr Phe Met Ser Lys Leu Glu 
    210                 215                 220                 


Glu Ile Leu Asn Tyr Gln Asp Met Phe Ala Ile Thr Tyr Leu His Val 
225                 230                 235                 240 


Leu Lys Gln Val Ser Asp Tyr Leu Asn Gly Asp Val Lys Ser Ile Glu 
                245                 250                 255     


Lys Ile Asp Asn Asp Ile Asn Met Ile Glu Lys Leu Gly Asn Pro Ile 
            260                 265                 270         


Ala Ala Ser Phe Leu Arg Ile Asn Leu Gln Gln Phe Leu His 
        275                 280                 285     


<210>  13
<211>  290
<212>  PRT
<213>  Streptococcus thermophilus

<400>  13

Met Leu Thr Lys Phe Gly Glu Ile Tyr Lys Leu Phe Arg Glu Ser Arg 
1               5                   10                  15      


Lys Ile Thr Leu Arg Asp Ile Glu His Arg Gly Ile Ser Arg Ser Gln 
            20                  25                  30          


Leu Ser Arg Phe Glu Lys Gly Glu Thr Asp Leu Thr Thr Thr Lys Phe 
        35                  40                  45              


Phe Leu Ala Leu Glu Gln Ile Asn Val Pro Ile Glu Glu Phe Met Tyr 
    50                  55                  60                  


Ala Val Lys Asp Phe Lys Arg Asp Cys Phe Tyr Gln Leu Ile Asp Glu 
65                  70                  75                  80  


Val Lys Gln Cys Phe Leu Asn Arg Asn Val Pro Lys Leu His Lys Met 
                85                  90                  95      


Leu Ile Lys Arg Met Glu Asn Asp Asp Thr Ser Ile Phe Ser Thr Ile 
            100                 105                 110         


Glu Ile Ile Phe Leu Lys Ile Lys Leu Gln Glu Leu Ser Gly Glu Glu 
        115                 120                 125             


Tyr Phe Asn Asp Thr Asp Ile Asn Arg Ile Thr Asp Tyr Leu Phe Gly 
    130                 135                 140                 


Val Asn Tyr Trp Gly Met Phe Glu Ile Leu Leu Phe Gly Asn Ile Met 
145                 150                 155                 160 


Tyr Ile Phe Asn Tyr Glu Thr Phe Leu Leu Leu Ser Lys Glu Leu Leu 
                165                 170                 175     


His Arg Thr Glu Phe Tyr His Asp Ile Pro Ser Tyr Arg Arg Val Ile 
            180                 185                 190         


Ala Ser Ile Ala Leu Asn Ala Phe Ile Ile Cys Ile Glu Arg Asp Tyr 
        195                 200                 205             


Leu Val Asp Ala Lys Tyr Phe Glu Lys Gln Ile Ser Arg Phe Tyr Phe 
    210                 215                 220                 


Asp Glu Ser Glu Ile Tyr Glu Arg Leu Ile Tyr Thr Tyr Ala Arg Ser 
225                 230                 235                 240 


Phe Tyr Glu Phe Lys Lys Lys Gln Thr Thr Gln Ser Ile Leu Lys Met 
                245                 250                 255     


Arg Lys Val Ile Gly Phe Met Arg Val Val Glu Cys Glu Lys Leu Ala 
            260                 265                 270         


Glu Arg Tyr Glu Glu His Leu Asn Lys Ile Leu Ser Ser Phe Ser Asp 
        275                 280                 285             


Asp Asn 
    290 


<210>  14
<211>  15
<212>  DNA
<213>  Streptococcus thermophilus

<400>  14
gcaaataggg gaata                                                        15


<210>  15
<211>  15
<212>  DNA
<213>  Streptococcus thermophilus

<400>  15
gcaaataggg gaatt                                                        15


<210>  16
<211>  15
<212>  DNA
<213>  Streptococcus thermophilus

<400>  16
gcatataggg gaata                                                        15


<210>  17
<211>  15
<212>  DNA
<213>  Streptococcus thermophilus

<400>  17
gcatataggg gaatt                                                        15


<210>  18
<211>  15
<212>  DNA
<213>  Streptococcus thermophilus

<400>  18
gcaaatatgg gaata                                                        15


<210>  19
<211>  15
<212>  DNA
<213>  Streptococcus thermophilus

<400>  19
gcaaatatgg gaatt                                                        15


<210>  20
<211>  15
<212>  DNA
<213>  Streptococcus thermophilus

<400>  20
gcatatatgg gaata                                                        15


<210>  21
<211>  15
<212>  DNA
<213>  Streptococcus thermophilus

<400>  21
gcatatatgg gaatt                                                        15


<210>  22
<211>  18
<212>  DNA
<213>  Streptococcus thermophilus

<400>  22
aattgcgtat aagggaaa                                                     18


<210>  23
<211>  18
<212>  DNA
<213>  Streptococcus thermophilus

<400>  23
aattgcttat aagggaaa                                                     18


<210>  24
<211>  9
<212>  PRT
<213>  Streptococcus thermophilus

<400>  24

Glu Gly Ile Ile Val Ile Val Val Gly 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  Streptococcus thermophilus

<400>  25

Glu Gly Ile Ile Val Ile Leu Val Gly 
1               5                   


<210>  26
<211>  9
<212>  PRT
<213>  Streptococcus thermophilus

<400>  26

Glu Gly Ile Ile Val Ile Gly Val Gly 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  Streptococcus thermophilus

<400>  27

Glu Ser Ile Ile Val Ile Ala Val Gly 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Streptococcus thermophilus

<400>  28

Asp Ile Ile Ile Phe Pro Pro Phe Gly 
1               5                   


<210>  29
<211>  8
<212>  PRT
<213>  Streptococcus thermophilus

<400>  29

Asp Ile Ile Ile Ile Val Gly Gly 
1               5               


<210>  30
<211>  8
<212>  PRT
<213>  Streptococcus thermophilus

<400>  30

Glu Ile Ile Ile Ile Ile Ala Leu 
1               5               


<210>  31
<211>  9
<212>  PRT
<213>  Streptococcus thermophilus

<400>  31

Cys Ile Tyr Thr Ile Val Gly Gly Val 
1               5                   


<210>  32
<211>  9
<212>  PRT
<213>  Streptococcus thermophilus

<400>  32

Cys Ile Tyr Ile Ile Val Gly Gly Val 
1               5                   


<210>  33
<211>  23
<212>  PRT
<213>  Streptococcus thermophilus

<400>  33

Met Lys Lys Gln Ile Leu Leu Thr Leu Leu Leu Val Val Phe Glu Gly 
1               5                   10                  15      


Ile Ile Val Ile Val Val Gly 
            20              


<210>  34
<211>  23
<212>  PRT
<213>  Streptococcus thermophilus

<400>  34

Met Lys Lys Gln Lys Leu Leu Leu Leu Val Val Leu Val Cys Glu Gly 
1               5                   10                  15      


Ile Ile Val Ile Leu Val Gly 
            20              


<210>  35
<211>  23
<212>  PRT
<213>  Streptococcus thermophilus

<400>  35

Met Asn Lys Lys Ala Leu Phe Ser Leu Leu Phe Val Ile Leu Glu Gly 
1               5                   10                  15      


Ile Ile Val Ile Gly Val Gly 
            20              


<210>  36
<211>  23
<212>  PRT
<213>  Streptococcus thermophilus

<400>  36

Met Asn Lys Glu Ser Phe Leu Ala Ile Leu Leu Leu Ile Phe Glu Ser 
1               5                   10                  15      


Ile Ile Val Ile Ala Val Gly 
            20              


<210>  37
<211>  26
<212>  PRT
<213>  Streptococcus thermophilus

<400>  37

Met Lys Lys Val Ile Ala Ile Phe Leu Phe Ile Gln Thr Val Val Val 
1               5                   10                  15      


Ile Asp Ile Ile Ile Phe Pro Pro Phe Gly 
            20                  25      


<210>  38
<211>  23
<212>  PRT
<213>  Streptococcus thermophilus

<400>  38

Met Glu Lys Val Ser Lys Ile Leu Pro Ile Leu Ile Leu Val Met Asp 
1               5                   10                  15      


Ile Ile Ile Ile Val Gly Gly 
            20              


<210>  39
<211>  21
<212>  PRT
<213>  Streptococcus thermophilus

<400>  39

Met Asn Ile Ser Ile Lys Arg Phe Leu Met Ile Leu Leu Glu Ile Ile 
1               5                   10                  15      


Ile Ile Ile Ala Leu 
            20      


<210>  40
<211>  20
<212>  PRT
<213>  Streptococcus thermophilus

<400>  40

Met Lys Leu Leu Lys Ile Ile Val Leu Leu Thr Cys Ile Tyr Thr Ile 
1               5                   10                  15      


Val Gly Gly Val 
            20  


<210>  41
<211>  20
<212>  PRT
<213>  Streptococcus thermophilus

<400>  41

Met Lys Leu Leu Lys Ile Ile Val Leu Leu Thr Cys Ile Tyr Ile Ile 
1               5                   10                  15      


Val Gly Gly Val 
            20  


<210>  42
<211>  243
<212>  PRT
<213>  Streptococcus thermophilus

<400>  42

Met Leu Lys Leu Glu Lys Val Thr Gly Gly Tyr Ala Asn Ile Pro Val 
1               5                   10                  15      


Leu Lys Asp Val Thr Phe Glu Val Ala Asp Gly Glu Leu Val Gly Leu 
            20                  25                  30          


Ile Gly Leu Asn Gly Ala Gly Lys Ser Thr Thr Ile Asn Glu Ile Ile 
        35                  40                  45              


Gly Leu Leu Thr Pro Tyr Gly Gly Gln Ile Ala Ile Asp Gly Leu Thr 
    50                  55                  60                  


Ile Gln Gln Asp Pro Ala Ser Tyr Arg Gln Lys Ile Gly Tyr Ile Pro 
65                  70                  75                  80  


Glu Thr Pro Ser Leu Tyr Glu Glu Leu Thr Leu Arg Glu His Leu Glu 
                85                  90                  95      


Thr Val Leu Met Ala Tyr Gly Leu Asp Val Thr Glu Gly Met Ala Arg 
            100                 105                 110         


Ala Asp Lys Tyr Leu Lys Leu Phe Arg Leu Asp Glu Lys Leu Asp Trp 
        115                 120                 125             


Phe Pro Thr Gln Phe Ser Lys Gly Met Lys Gln Lys Val Met Ile Ile 
    130                 135                 140                 


Cys Ala Phe Ile Val Asn Pro Ser Leu Phe Ile Val Asp Glu Pro Phe 
145                 150                 155                 160 


Leu Gly Leu Asp Pro Leu Ala Ile Ser Asp Leu Ile Glu Leu Leu Ala 
                165                 170                 175     


Glu Glu Lys Ala Asn Gly Lys Ser Ile Leu Met Ser Thr His Val Leu 
            180                 185                 190         


Asp Ser Ala Glu Lys Met Cys Asp Arg Phe Val Ile Leu His His Gly 
        195                 200                 205             


Gln Ile Leu Ala Gln Gly Thr Ile Asp Glu Leu Arg Gln Thr Phe Gly 
    210                 215                 220                 


Asp Ser Ser Ala Ser Leu Asn Asp Ile Tyr Met Gln Leu Thr Lys Gly 
225                 230                 235                 240 


Glu Leu Ser 
            


<210>  43
<211>  345
<212>  PRT
<213>  Streptococcus thermophilus

<400>  43

Met Ile Ala Glu Leu Phe Lys Glu Arg Ser Arg Arg Leu Thr Thr Arg 
1               5                   10                  15      


Cys Ala Lys Tyr Ser Arg Tyr Val Phe Asn Asp His Phe Ile Leu Val 
            20                  25                  30          


Leu Leu Phe Leu Leu Gly Phe Val Leu Val Gln Tyr Ser Gln Leu Leu 
        35                  40                  45              


Arg His Phe Pro Lys Asn Pro Trp Ala Ile Ile Leu Gly Leu Leu Val 
    50                  55                  60                  


Leu Cys Leu Leu Leu Pro Phe Trp Gly Asn Ile Ala Thr Tyr Leu Glu 
65                  70                  75                  80  


Pro Ala Asp Lys His Tyr Leu Leu Val Lys Glu Glu Glu Val Leu Asp 
                85                  90                  95      


His Ile Lys Lys Ala Thr Gly Cys Ala Phe Arg Phe Trp Val Leu Ile 
            100                 105                 110         


Gln Thr Leu Ile Phe Ile Leu Val Val Pro Leu Phe Leu Ala Leu Gly 
        115                 120                 125             


Leu Pro Val Trp Gly Val Val Leu Val Ala Val Ala Met Ala Ile Leu 
    130                 135                 140                 


Lys Tyr Phe Ile Phe Gln Lys Lys Ala Gln Pro Phe Tyr Lys Gln Ser 
145                 150                 155                 160 


Gly Leu Asn Trp Thr Asp Ala Ile Ala Ala Glu Asn Lys Arg Gln Gln 
                165                 170                 175     


Ser Ile Leu Lys Phe Phe Ser Leu Phe Thr Asn Val Lys Gly Ile Thr 
            180                 185                 190         


Ser Ser Val Lys Arg Arg Gly Tyr Leu Asp Gly Ile Leu Lys Arg Thr 
        195                 200                 205             


Lys Lys Asp Lys Lys Tyr Thr Trp Tyr Asn Leu Tyr Leu Arg Ala Phe 
    210                 215                 220                 


Leu Arg Ser Gly Asp Tyr Phe Ala Leu Ser Leu Arg Leu Phe Ala Leu 
225                 230                 235                 240 


Thr Leu Leu Val Ile Phe Leu Val Pro Glu Lys Trp Leu Ala Met Val 
                245                 250                 255     


Leu Val Val Val Phe Asp Tyr Leu Leu Leu Phe Gln Leu Thr Ala Leu 
            260                 265                 270         


Lys Ser His Phe Ala Tyr Gln Arg Met Ala Asn Leu Met Pro Ile Gly 
        275                 280                 285             


Lys Asp Met Gln Val Ser Asn Leu Lys Arg Leu Ile Asn Gln Ile Val 
    290                 295                 300                 


Leu Val Met Thr Leu Ile Gln Ala Leu Cys Leu Phe Asp Leu Lys Phe 
305                 310                 315                 320 


Ser Leu Ile Leu Ile Gly Val Met Leu Val Leu Ser Leu Val Tyr Leu 
                325                 330                 335     


Pro Ala Lys Leu Lys Lys Met Ile Asp 
            340                 345 


<210>  44
<211>  420
<212>  PRT
<213>  Streptococcus thermophilus

<400>  44

Met Lys Ala Ile Ile Thr Phe Leu Leu Ile Phe Cys Val Ile Val Val 
1               5                   10                  15      


Phe His Glu Phe Gly His Phe Phe Phe Ala Lys Arg Ser Gly Ile Leu 
            20                  25                  30          


Val Arg Glu Phe Ala Ile Gly Met Gly Pro Lys Ile Phe Ala His Thr 
        35                  40                  45              


Gly Lys Asp Gly Thr Val Tyr Thr Ile Arg Ile Leu Pro Leu Gly Gly 
    50                  55                  60                  


Tyr Val Arg Met Ala Gly Trp Gly Glu Asp Thr Thr Glu Ile Lys Thr 
65                  70                  75                  80  


Gly Ser Pro Ala Ser Leu Thr Leu Gly Lys Asp Gly Lys Val Arg Arg 
                85                  90                  95      


Ile Asn Leu Ser Asp Arg Gln Val Asp Gln Thr Ala Leu Pro Met Asn 
            100                 105                 110         


Val Thr Ala Tyr Asp Leu Glu Asp Lys Leu Thr Ile Thr Gly Leu Val 
        115                 120                 125             


Leu Gly Glu Thr Lys Thr Tyr Glu Val Asp His Asp Ala Thr Ile Val 
    130                 135                 140                 


Glu Glu Asp Gly Thr Glu Leu Arg Ile Ala Pro Lys Asp Val Gln Tyr 
145                 150                 155                 160 


Gln Asn Ala Ser Ile Trp Gly Arg Leu Ile Thr Asn Phe Ala Gly Pro 
                165                 170                 175     


Met Asn Asn Phe Ile Leu Gly Val Leu Val Phe Ile Ile Leu Ala Phe 
            180                 185                 190         


Val Gln Gly Gly Val Gln Asp Thr Ser Thr Asn Leu Ile Gln Val Thr 
        195                 200                 205             


Asn Gly Gly Ala Ala Gln Val Ser Gly Leu Lys Thr Gly Asp Ala Ile 
    210                 215                 220                 


Val Ala Ile Asn Lys Asp Lys Val Thr Asp Trp Asp Ser Leu Lys Glu 
225                 230                 235                 240 


Ala Leu Arg Glu Asn Thr Gln Lys Phe Ser Lys Gly Asp Ser Leu Ser 
                245                 250                 255     


Val Thr Val Lys Arg Ser Asn Gly Gln Glu Glu Thr Ile Ser Val Lys 
            260                 265                 270         


Pro Gln Glu Ser Gln Gly Ser Tyr Phe Leu Gly Val Ser Pro Val Leu 
        275                 280                 285             


Lys Thr Gly Leu Lys Asp Lys Ile Phe Gly Gly Phe Gln Met Ala Trp 
    290                 295                 300                 


Glu Gly Ala Thr Ala Ile Leu Ala Thr Leu Lys Gly Leu Ile Thr Asn 
305                 310                 315                 320 


Phe Ser Leu Asn Lys Leu Gly Gly Pro Val Ala Met Phe Gln Met Ser 
                325                 330                 335     


Ala Gln Ala Ser Glu Ser Gly Leu Ile Ser Ile Leu Asp Leu Met Gly 
            340                 345                 350         


Met Leu Ser Ile Asn Leu Gly Ile Phe Asn Leu Ile Pro Ile Pro Ala 
        355                 360                 365             


Leu Asp Gly Gly Lys Ile Val Met Asn Ile Ile Glu Ala Ile Arg Arg 
    370                 375                 380                 


Lys Pro Leu Asn Gln Lys Ile Glu Ser Tyr Ile Thr Leu Ala Gly Val 
385                 390                 395                 400 


Ala Val Met Val Val Leu Met Ile Ala Val Thr Trp Asn Asp Ile Met 
                405                 410                 415     


Arg Ala Phe Phe 
            420 


<210>  45
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic peptide

<400>  45

Leu Pro Tyr Phe Ala Gly Cys Leu 
1               5               


