                         SEQUENCE LISTING

<110>  Cedars-Sinai Medical Center
 
<120>  THERAPEUTIC NUCLEIC ACIDS AND METHODS OF USE THEREOF

<130>  CSMC.018WO

<150>  63/202970
<151>  2021-07-01

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  1
ggcugguccg augguagugg guuaucagaa cuuauuaaca uuagugucac uaaagu           56


<210>  2
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  LNA

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  LNA

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  LNA

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  LNA

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  LNA

<400>  2
cguccgaugg uaguggguua ucag                                              24


<210>  3
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  3
ggtccgatgg tagtgggtta tc                                                22


<210>  4
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  4
ggtccgaagg tagtgagtta tc                                                22


<210>  5
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  5
ggtccgatgg tagtgggtta tcag                                              24


<210>  6
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  6
gguccgaugg uaguggguua ucag                                              24


<210>  7
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  7
cugguccgau gguagugggu uaucagaacu uauuaacauu agugucacua aagu             54


<210>  8
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  8
cugguccgau gguagugggu uaucagaacu uauuaacauu agugucacua aaga             54


<210>  9
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  LNA

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  LNA

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  LNA

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  LNA

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  LNA

<400>  9
cugguccgau gguagugggu uaucagaacu uauuaacauu agugucacua aaga             54


<210>  10
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  LNA

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  LNA

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  LNA

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  LNA

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  LNA

<400>  10
cugguccgau gguagugggu uaucagaacu uauuaacauu agugucacua aaga             54


<210>  11
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  11
gguccgaugg uaguggguua ucag                                              24


<210>  12
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  12
cguccgaugg uaguggguua ucag                                              24


<210>  13
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  LNA

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  LNA

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  LNA

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  LNA

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  LNA

<400>  13
cguccgaugg uaguggguua ucag                                              24


<210>  14
<211>  50
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  14
ggcugguccg augguagugg guuaucagaa cuuauuaaca uuagugucac                  50


<210>  15
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  LNA

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  LNA

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  LNA

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  LNA

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  LNA

<400>  15
uauagcgggu gugaccugga cugu                                              24


<210>  16
<211>  2363
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Ala Val Leu Gln Gln Val Leu Glu Arg Thr Glu Leu Asn Lys 
1               5                   10                  15      


Leu Pro Lys Ser Val Gln Asn Lys Leu Glu Lys Phe Leu Ala Asp Gln 
            20                  25                  30          


Gln Ser Glu Ile Asp Gly Leu Lys Gly Arg His Glu Lys Phe Lys Val 
        35                  40                  45              


Glu Ser Glu Gln Gln Tyr Phe Glu Ile Glu Lys Arg Leu Ser His Ser 
    50                  55                  60                  


Gln Glu Arg Leu Val Asn Glu Thr Arg Glu Cys Gln Ser Leu Arg Leu 
65                  70                  75                  80  


Glu Leu Glu Lys Leu Asn Asn Gln Leu Lys Ala Leu Thr Glu Lys Asn 
                85                  90                  95      


Lys Glu Leu Glu Ile Ala Gln Asp Arg Asn Ile Ala Ile Gln Ser Gln 
            100                 105                 110         


Phe Thr Arg Thr Lys Glu Glu Leu Glu Ala Glu Lys Arg Asp Leu Ile 
        115                 120                 125             


Arg Thr Asn Glu Arg Leu Ser Gln Glu Leu Glu Tyr Leu Thr Glu Asp 
    130                 135                 140                 


Val Lys Arg Leu Asn Glu Lys Leu Lys Glu Ser Asn Thr Thr Lys Gly 
145                 150                 155                 160 


Glu Leu Gln Leu Lys Leu Asp Glu Leu Gln Ala Ser Asp Val Ser Val 
                165                 170                 175     


Lys Tyr Arg Glu Lys Arg Leu Glu Gln Glu Lys Glu Leu Leu His Ser 
            180                 185                 190         


Gln Asn Thr Trp Leu Asn Thr Glu Leu Lys Thr Lys Thr Asp Glu Leu 
        195                 200                 205             


Leu Ala Leu Gly Arg Glu Lys Gly Asn Glu Ile Leu Glu Leu Lys Cys 
    210                 215                 220                 


Asn Leu Glu Asn Lys Lys Glu Glu Val Ser Arg Leu Glu Glu Gln Met 
225                 230                 235                 240 


Asn Gly Leu Lys Thr Ser Asn Glu His Leu Gln Lys His Val Glu Asp 
                245                 250                 255     


Leu Leu Thr Lys Leu Lys Glu Ala Lys Glu Gln Gln Ala Ser Met Glu 
            260                 265                 270         


Glu Lys Phe His Asn Glu Leu Asn Ala His Ile Lys Leu Ser Asn Leu 
        275                 280                 285             


Tyr Lys Ser Ala Ala Asp Asp Ser Glu Ala Lys Ser Asn Glu Leu Thr 
    290                 295                 300                 


Arg Ala Val Glu Glu Leu His Lys Leu Leu Lys Glu Ala Gly Glu Ala 
305                 310                 315                 320 


Asn Lys Ala Ile Gln Asp His Leu Leu Glu Val Glu Gln Ser Lys Asp 
                325                 330                 335     


Gln Met Glu Lys Glu Met Leu Glu Lys Ile Gly Arg Leu Glu Lys Glu 
            340                 345                 350         


Leu Glu Asn Ala Asn Asp Leu Leu Ser Ala Thr Lys Arg Lys Gly Ala 
        355                 360                 365             


Ile Leu Ser Glu Glu Glu Leu Ala Ala Met Ser Pro Thr Ala Ala Ala 
    370                 375                 380                 


Val Ala Lys Ile Val Lys Pro Gly Met Lys Leu Thr Glu Leu Tyr Asn 
385                 390                 395                 400 


Ala Tyr Val Glu Thr Gln Asp Gln Leu Leu Leu Glu Lys Leu Glu Asn 
                405                 410                 415     


Lys Arg Ile Asn Lys Tyr Leu Asp Glu Ile Val Lys Glu Val Glu Ala 
            420                 425                 430         


Lys Ala Pro Ile Leu Lys Arg Gln Arg Glu Glu Tyr Glu Arg Ala Gln 
        435                 440                 445             


Lys Ala Val Ala Ser Leu Ser Val Lys Leu Glu Gln Ala Met Lys Glu 
    450                 455                 460                 


Ile Gln Arg Leu Gln Glu Asp Thr Asp Lys Ala Asn Lys Gln Ser Ser 
465                 470                 475                 480 


Val Leu Glu Arg Asp Asn Arg Arg Met Glu Ile Gln Val Lys Asp Leu 
                485                 490                 495     


Ser Gln Gln Ile Arg Val Leu Leu Met Glu Leu Glu Glu Ala Arg Gly 
            500                 505                 510         


Asn His Val Ile Arg Asp Glu Glu Val Ser Ser Ala Asp Ile Ser Ser 
        515                 520                 525             


Ser Ser Glu Val Ile Ser Gln His Leu Val Ser Tyr Arg Asn Ile Glu 
    530                 535                 540                 


Glu Leu Gln Gln Gln Asn Gln Arg Leu Leu Val Ala Leu Arg Glu Leu 
545                 550                 555                 560 


Gly Glu Thr Arg Glu Arg Glu Glu Gln Glu Thr Thr Ser Ser Lys Ile 
                565                 570                 575     


Thr Glu Leu Gln Leu Lys Leu Glu Ser Ala Leu Thr Glu Leu Glu Gln 
            580                 585                 590         


Leu Arg Lys Ser Arg Gln His Gln Met Gln Leu Val Asp Ser Ile Val 
        595                 600                 605             


Arg Gln Arg Asp Met Tyr Arg Ile Leu Leu Ser Gln Thr Thr Gly Val 
    610                 615                 620                 


Ala Ile Pro Leu His Ala Ser Ser Leu Asp Asp Val Ser Leu Ala Ser 
625                 630                 635                 640 


Thr Pro Lys Arg Pro Ser Thr Ser Gln Thr Val Ser Thr Pro Ala Pro 
                645                 650                 655     


Val Pro Val Ile Glu Ser Thr Glu Ala Ile Glu Ala Lys Ala Ala Leu 
            660                 665                 670         


Lys Gln Leu Gln Glu Ile Phe Glu Asn Tyr Lys Lys Glu Lys Ala Glu 
        675                 680                 685             


Asn Glu Lys Ile Gln Asn Glu Gln Leu Glu Lys Leu Gln Glu Gln Val 
    690                 695                 700                 


Thr Asp Leu Arg Ser Gln Asn Thr Lys Ile Ser Thr Gln Leu Asp Phe 
705                 710                 715                 720 


Ala Ser Lys Arg Tyr Glu Met Leu Gln Asp Asn Val Glu Gly Tyr Arg 
                725                 730                 735     


Arg Glu Ile Thr Ser Leu His Glu Arg Asn Gln Lys Leu Thr Ala Thr 
            740                 745                 750         


Thr Gln Lys Gln Glu Gln Ile Ile Asn Thr Met Thr Gln Asp Leu Arg 
        755                 760                 765             


Gly Ala Asn Glu Lys Leu Ala Val Ala Glu Val Arg Ala Glu Asn Leu 
    770                 775                 780                 


Lys Lys Glu Lys Glu Met Leu Lys Leu Ser Glu Val Arg Leu Ser Gln 
785                 790                 795                 800 


Gln Arg Glu Ser Leu Leu Ala Glu Gln Arg Gly Gln Asn Leu Leu Leu 
                805                 810                 815     


Thr Asn Leu Gln Thr Ile Gln Gly Ile Leu Glu Arg Ser Glu Thr Glu 
            820                 825                 830         


Thr Lys Gln Arg Leu Ser Ser Gln Ile Glu Lys Leu Glu His Glu Ile 
        835                 840                 845             


Ser His Leu Lys Lys Lys Leu Glu Asn Glu Val Glu Gln Arg His Thr 
    850                 855                 860                 


Leu Thr Arg Asn Leu Asp Val Gln Leu Leu Asp Thr Lys Arg Gln Leu 
865                 870                 875                 880 


Asp Thr Glu Thr Asn Leu His Leu Asn Thr Lys Glu Leu Leu Lys Asn 
                885                 890                 895     


Ala Gln Lys Glu Ile Ala Thr Leu Lys Gln His Leu Ser Asn Met Glu 
            900                 905                 910         


Val Gln Val Ala Ser Gln Ser Ser Gln Arg Thr Gly Lys Gly Gln Pro 
        915                 920                 925             


Ser Asn Lys Glu Asp Val Asp Asp Leu Val Ser Gln Leu Arg Gln Thr 
    930                 935                 940                 


Glu Glu Gln Val Asn Asp Leu Lys Glu Arg Leu Lys Thr Ser Thr Ser 
945                 950                 955                 960 


Asn Val Glu Gln Tyr Gln Ala Met Val Thr Ser Leu Glu Glu Ser Leu 
                965                 970                 975     


Asn Lys Glu Lys Gln Val Thr Glu Glu Val Arg Lys Asn Ile Glu Val 
            980                 985                 990         


Arg Leu Lys Glu Ser Ala Glu Phe  Gln Thr Gln Leu Glu  Lys Lys Leu 
        995                 1000                 1005             


Met Glu  Val Glu Lys Glu Lys  Gln Glu Leu Gln Asp  Asp Lys Arg 
    1010                 1015                 1020             


Arg Ala  Ile Glu Ser Met Glu  Gln Gln Leu Ser Glu  Leu Lys Lys 
    1025                 1030                 1035             


Thr Leu  Ser Ser Val Gln Asn  Glu Val Gln Glu Ala  Leu Gln Arg 
    1040                 1045                 1050             


Ala Ser  Thr Ala Leu Ser Asn  Glu Gln Gln Ala Arg  Arg Asp Cys 
    1055                 1060                 1065             


Gln Glu  Gln Ala Lys Ile Ala  Val Glu Ala Gln Asn  Lys Tyr Glu 
    1070                 1075                 1080             


Arg Glu  Leu Met Leu His Ala  Ala Asp Val Glu Ala  Leu Gln Ala 
    1085                 1090                 1095             


Ala Lys  Glu Gln Val Ser Lys  Met Ala Ser Val Arg  Gln His Leu 
    1100                 1105                 1110             


Glu Glu  Thr Thr Gln Lys Ala  Glu Ser Gln Leu Leu  Glu Cys Lys 
    1115                 1120                 1125             


Ala Ser  Trp Glu Glu Arg Glu  Arg Met Leu Lys Asp  Glu Val Ser 
    1130                 1135                 1140             


Lys Cys  Val Cys Arg Cys Glu  Asp Leu Glu Lys Gln  Asn Arg Leu 
    1145                 1150                 1155             


Leu His  Asp Gln Ile Glu Lys  Leu Ser Asp Lys Val  Val Ala Ser 
    1160                 1165                 1170             


Val Lys  Glu Gly Val Gln Gly  Pro Leu Asn Val Ser  Leu Ser Glu 
    1175                 1180                 1185             


Glu Gly  Lys Ser Gln Glu Gln  Ile Leu Glu Ile Leu  Arg Phe Ile 
    1190                 1195                 1200             


Arg Arg  Glu Lys Glu Ile Ala  Glu Thr Arg Phe Glu  Val Ala Gln 
    1205                 1210                 1215             


Val Glu  Ser Leu Arg Tyr Arg  Gln Arg Val Glu Leu  Leu Glu Arg 
    1220                 1225                 1230             


Glu Leu  Gln Glu Leu Gln Asp  Ser Leu Asn Ala Glu  Arg Glu Lys 
    1235                 1240                 1245             


Val Gln  Val Thr Ala Lys Thr  Met Ala Gln His Glu  Glu Leu Met 
    1250                 1255                 1260             


Lys Lys  Thr Glu Thr Met Asn  Val Val Met Glu Thr  Asn Lys Met 
    1265                 1270                 1275             


Leu Arg  Glu Glu Lys Glu Arg  Leu Glu Gln Asp Leu  Gln Gln Met 
    1280                 1285                 1290             


Gln Ala  Lys Val Arg Lys Leu  Glu Leu Asp Ile Leu  Pro Leu Gln 
    1295                 1300                 1305             


Glu Ala  Asn Ala Glu Leu Ser  Glu Lys Ser Gly Met  Leu Gln Ala 
    1310                 1315                 1320             


Glu Lys  Lys Leu Leu Glu Glu  Asp Val Lys Arg Trp  Lys Ala Arg 
    1325                 1330                 1335             


Asn Gln  His Leu Val Ser Gln  Gln Lys Asp Pro Asp  Thr Glu Glu 
    1340                 1345                 1350             


Tyr Arg  Lys Leu Leu Ser Glu  Lys Glu Val His Thr  Lys Arg Ile 
    1355                 1360                 1365             


Gln Gln  Leu Thr Glu Glu Ile  Gly Arg Leu Lys Ala  Glu Ile Ala 
    1370                 1375                 1380             


Arg Ser  Asn Ala Ser Leu Thr  Asn Asn Gln Asn Leu  Ile Gln Ser 
    1385                 1390                 1395             


Leu Lys  Glu Asp Leu Asn Lys  Val Arg Thr Glu Lys  Glu Thr Ile 
    1400                 1405                 1410             


Gln Lys  Asp Leu Asp Ala Lys  Ile Ile Asp Ile Gln  Glu Lys Val 
    1415                 1420                 1425             


Lys Thr  Ile Thr Gln Val Lys  Lys Ile Gly Arg Arg  Tyr Lys Thr 
    1430                 1435                 1440             


Gln Tyr  Glu Glu Leu Lys Ala  Gln Gln Asp Lys Val  Met Glu Thr 
    1445                 1450                 1455             


Ser Ala  Gln Ser Ser Gly Asp  His Gln Glu Gln His  Val Ser Val 
    1460                 1465                 1470             


Gln Glu  Met Gln Glu Leu Lys  Glu Thr Leu Asn Gln  Ala Glu Thr 
    1475                 1480                 1485             


Lys Ser  Lys Ser Leu Glu Ser  Gln Val Glu Asn Leu  Gln Lys Thr 
    1490                 1495                 1500             


Leu Ser  Glu Lys Glu Thr Glu  Ala Arg Asn Leu Gln  Glu Gln Thr 
    1505                 1510                 1515             


Val Gln  Leu Gln Ser Glu Leu  Ser Arg Leu Arg Gln  Asp Leu Gln 
    1520                 1525                 1530             


Asp Arg  Thr Thr Gln Glu Glu  Gln Leu Arg Gln Gln  Ile Thr Glu 
    1535                 1540                 1545             


Lys Glu  Glu Lys Thr Arg Lys  Ala Ile Val Ala Ala  Lys Ser Lys 
    1550                 1555                 1560             


Ile Ala  His Leu Ala Gly Val  Lys Asp Gln Leu Thr  Lys Glu Asn 
    1565                 1570                 1575             


Glu Glu  Leu Lys Gln Arg Asn  Gly Ala Leu Asp Gln  Gln Lys Asp 
    1580                 1585                 1590             


Glu Leu  Asp Val Arg Ile Thr  Ala Leu Lys Ser Gln  Tyr Glu Gly 
    1595                 1600                 1605             


Arg Ile  Ser Arg Leu Glu Arg  Glu Leu Arg Glu His  Gln Glu Arg 
    1610                 1615                 1620             


His Leu  Glu Gln Arg Asp Glu  Pro Gln Glu Pro Ser  Asn Lys Val 
    1625                 1630                 1635             


Pro Glu  Gln Gln Arg Gln Ile  Thr Leu Lys Thr Thr  Pro Ala Ser 
    1640                 1645                 1650             


Gly Glu  Arg Gly Ile Ala Ser  Thr Ser Asp Pro Pro  Thr Ala Asn 
    1655                 1660                 1665             


Ile Lys  Pro Thr Pro Val Val  Ser Thr Pro Ser Lys  Val Thr Ala 
    1670                 1675                 1680             


Ala Ala  Met Ala Gly Asn Lys  Ser Thr Pro Arg Ala  Ser Ile Arg 
    1685                 1690                 1695             


Pro Met  Val Thr Pro Ala Thr  Val Thr Asn Pro Thr  Thr Thr Pro 
    1700                 1705                 1710             


Thr Ala  Thr Val Met Pro Thr  Thr Gln Val Glu Ser  Gln Glu Ala 
    1715                 1720                 1725             


Met Gln  Ser Glu Gly Pro Val  Glu His Val Pro Val  Phe Gly Ser 
    1730                 1735                 1740             


Thr Ser  Gly Ser Val Arg Ser  Thr Ser Pro Asn Val  Gln Pro Ser 
    1745                 1750                 1755             


Ile Ser  Gln Pro Ile Leu Thr  Val Gln Gln Gln Thr  Gln Ala Thr 
    1760                 1765                 1770             


Ala Phe  Val Gln Pro Thr Gln  Gln Ser His Pro Gln  Ile Glu Pro 
    1775                 1780                 1785             


Ala Asn  Gln Glu Leu Ser Ser  Asn Ile Val Glu Val  Val Gln Ser 
    1790                 1795                 1800             


Ser Pro  Val Glu Arg Pro Ser  Thr Ser Thr Ala Val  Phe Gly Thr 
    1805                 1810                 1815             


Val Ser  Ala Thr Pro Ser Ser  Ser Leu Pro Lys Arg  Thr Arg Glu 
    1820                 1825                 1830             


Glu Glu  Glu Asp Ser Thr Ile  Glu Ala Ser Asp Gln  Val Ser Asp 
    1835                 1840                 1845             


Asp Thr  Val Glu Met Pro Leu  Pro Lys Lys Leu Lys  Ser Val Thr 
    1850                 1855                 1860             


Pro Val  Gly Thr Glu Glu Glu  Val Met Ala Glu Glu  Ser Thr Asp 
    1865                 1870                 1875             


Gly Glu  Val Glu Thr Gln Val  Tyr Asn Gln Asp Ser  Gln Asp Ser 
    1880                 1885                 1890             


Ile Gly  Glu Gly Val Thr Gln  Gly Asp Tyr Thr Pro  Met Glu Asp 
    1895                 1900                 1905             


Ser Glu  Glu Thr Ser Gln Ser  Leu Gln Ile Asp Leu  Gly Pro Leu 
    1910                 1915                 1920             


Gln Ser  Asp Gln Gln Thr Thr  Thr Ser Ser Gln Asp  Gly Gln Gly 
    1925                 1930                 1935             


Lys Gly  Asp Asp Val Ile Val  Ile Asp Ser Asp Asp  Glu Glu Glu 
    1940                 1945                 1950             


Asp Asp  Asp Glu Asn Asp Gly  Glu His Glu Asp Tyr  Glu Glu Asp 
    1955                 1960                 1965             


Glu Glu  Asp Asp Asp Asp Asp  Glu Asp Asp Thr Gly  Met Gly Asp 
    1970                 1975                 1980             


Glu Gly  Glu Asp Ser Asn Glu  Gly Thr Gly Ser Ala  Asp Gly Asn 
    1985                 1990                 1995             


Asp Gly  Tyr Glu Ala Asp Asp  Ala Glu Gly Gly Asp  Gly Thr Asp 
    2000                 2005                 2010             


Pro Gly  Thr Glu Thr Glu Glu  Ser Met Gly Gly Gly  Glu Gly Asn 
    2015                 2020                 2025             


His Arg  Ala Ala Asp Ser Gln  Asn Ser Gly Glu Gly  Asn Thr Gly 
    2030                 2035                 2040             


Ala Ala  Glu Ser Ser Phe Ser  Gln Glu Val Ser Arg  Glu Gln Gln 
    2045                 2050                 2055             


Pro Ser  Ser Ala Ser Glu Arg  Gln Ala Pro Arg Ala  Pro Gln Ser 
    2060                 2065                 2070             


Pro Arg  Arg Pro Pro His Pro  Leu Pro Pro Arg Leu  Thr Ile His 
    2075                 2080                 2085             


Ala Pro  Pro Gln Glu Leu Gly  Pro Pro Val Gln Arg  Ile Gln Met 
    2090                 2095                 2100             


Thr Arg  Arg Gln Ser Val Gly  Arg Gly Leu Gln Leu  Thr Pro Gly 
    2105                 2110                 2115             


Ile Gly  Gly Met Gln Gln His  Phe Phe Asp Asp Glu  Asp Arg Thr 
    2120                 2125                 2130             


Val Pro  Ser Thr Pro Thr Leu  Val Val Pro His Arg  Thr Asp Gly 
    2135                 2140                 2145             


Phe Ala  Glu Ala Ile His Ser  Pro Gln Val Ala Gly  Val Pro Arg 
    2150                 2155                 2160             


Phe Arg  Phe Gly Pro Pro Glu  Asp Met Pro Gln Thr  Ser Ser Ser 
    2165                 2170                 2175             


His Ser  Asp Leu Gly Gln Leu  Ala Ser Gln Gly Gly  Leu Gly Met 
    2180                 2185                 2190             


Tyr Glu  Thr Pro Leu Phe Leu  Ala His Glu Glu Glu  Ser Gly Gly 
    2195                 2200                 2205             


Arg Ser  Val Pro Thr Thr Pro  Leu Gln Val Ala Ala  Pro Val Thr 
    2210                 2215                 2220             


Val Phe  Thr Glu Ser Thr Thr  Ser Asp Ala Ser Glu  His Ala Ser 
    2225                 2230                 2235             


Gln Ser  Val Pro Met Val Thr  Thr Ser Thr Gly Thr  Leu Ser Thr 
    2240                 2245                 2250             


Thr Asn  Glu Thr Ala Thr Gly  Asp Asp Gly Asp Glu  Val Phe Val 
    2255                 2260                 2265             


Glu Ala  Glu Ser Glu Gly Ile  Ser Ser Glu Ala Gly  Leu Glu Ile 
    2270                 2275                 2280             


Asp Ser  Gln Gln Glu Glu Glu  Pro Val Gln Ala Ser  Asp Glu Ser 
    2285                 2290                 2295             


Asp Leu  Pro Ser Thr Ser Gln  Asp Pro Pro Ser Ser  Ser Ser Val 
    2300                 2305                 2310             


Asp Thr  Ser Ser Ser Gln Pro  Lys Pro Phe Arg Arg  Val Arg Leu 
    2315                 2320                 2325             


Gln Thr  Thr Leu Arg Gln Gly  Val Arg Gly Arg Gln  Phe Asn Arg 
    2330                 2335                 2340             


Gln Arg  Gly Val Ser His Ala  Met Gly Gly Arg Gly  Gly Ile Asn 
    2345                 2350                 2355             


Arg Gly  Asn Ile Asn 
    2360             


<210>  17
<211>  214
<212>  PRT
<213>  Bos taurus

<400>  17

Met Lys Leu Leu Ile Leu Thr Cys Leu Val Ala Val Ala Leu Ala Arg 
1               5                   10                  15      


Pro Lys His Pro Ile Lys His Gln Gly Leu Pro Gln Glu Val Leu Asn 
            20                  25                  30          


Glu Asn Leu Leu Arg Phe Phe Val Ala Pro Phe Pro Glu Val Phe Gly 
        35                  40                  45              


Lys Glu Lys Val Asn Glu Leu Ser Lys Asp Ile Gly Ser Glu Ser Thr 
    50                  55                  60                  


Glu Asp Gln Ala Met Glu Asp Ile Lys Gln Met Glu Ala Glu Ser Ile 
65                  70                  75                  80  


Ser Ser Ser Glu Glu Ile Val Pro Asn Ser Val Glu Gln Lys His Ile 
                85                  90                  95      


Gln Lys Asp Asp Val Pro Ser Glu Arg Tyr Leu Gly Tyr Leu Glu Gln 
            100                 105                 110         


Leu Leu Arg Leu Lys Lys Tyr Lys Val Pro Gln Leu Glu Ile Val Pro 
        115                 120                 125             


Asn Ser Ala Glu Glu Arg Leu His Ser Met Lys Glu Gly Ile His Ala 
    130                 135                 140                 


Gln Gln Lys Glu Pro Met Ile Gly Val Asn Gln Glu Leu Ala Tyr Phe 
145                 150                 155                 160 


Tyr Pro Glu Leu Phe Arg Gln Phe Tyr Gln Leu Asp Ala Tyr Pro Ser 
                165                 170                 175     


Gly Ala Trp Tyr Tyr Val Pro Leu Gly Thr Gln Tyr Thr Asp Ala Pro 
            180                 185                 190         


Ser Phe Ser Asp Ile Pro Asn Pro Ile Gly Ser Glu Asn Ser Gly Lys 
        195                 200                 205             


Thr Thr Met Pro Leu Trp 
    210                 


<210>  18
<211>  222
<212>  PRT
<213>  Bos taurus

<400>  18

Met Lys Phe Phe Ile Phe Thr Cys Leu Leu Ala Val Ala Leu Ala Lys 
1               5                   10                  15      


Asn Thr Met Glu His Val Ser Ser Ser Glu Glu Ser Ile Ile Ser Gln 
            20                  25                  30          


Glu Thr Tyr Lys Gln Glu Lys Asn Met Ala Ile Asn Pro Ser Lys Glu 
        35                  40                  45              


Asn Leu Cys Ser Thr Phe Cys Lys Glu Val Val Arg Asn Ala Asn Glu 
    50                  55                  60                  


Glu Glu Tyr Ser Ile Gly Ser Ser Ser Glu Glu Ser Ala Val Val Ala 
65                  70                  75                  80  


Thr Glu Glu Val Lys Ile Thr Val Asp Asp Lys His Tyr Gln Lys Ala 
                85                  90                  95      


Leu Asn Glu Ile Asn Gln Phe Tyr Gln Lys Phe Pro Gln Tyr Leu Gln 
            100                 105                 110         


Tyr Leu Tyr Gln Gly Pro Ile Val Leu Asn Pro Trp Asp Gln Val Lys 
        115                 120                 125             


Arg Asn Ala Val Pro Ile Thr Pro Thr Leu Asn Arg Glu Gln Leu Ser 
    130                 135                 140                 


Thr Ser Glu Glu Asn Ser Lys Lys Thr Val Asp Met Glu Ser Thr Glu 
145                 150                 155                 160 


Val Phe Thr Lys Lys Thr Lys Leu Thr Glu Glu Glu Lys Asn Arg Leu 
                165                 170                 175     


Asn Phe Leu Lys Lys Ile Ser Gln Arg Tyr Gln Lys Phe Ala Leu Pro 
            180                 185                 190         


Gln Tyr Leu Lys Thr Val Tyr Gln His Gln Lys Ala Met Glu Pro Trp 
        195                 200                 205             


Ile Gln Pro Lys Thr Lys Val Ile Pro Tyr Val Arg Tyr Leu 
    210                 215                 220         


<210>  19
<211>  259
<212>  PRT
<213>  Bos taurus

<400>  19

Met Pro Leu Asn Thr Ile Tyr Lys Gln Pro Gln Asn Gln Ile Ile Ile 
1               5                   10                  15      


His Ser Ala Pro Pro Ser Leu Leu Val Leu Tyr Phe Gly Lys Lys Glu 
            20                  25                  30          


Leu Arg Ala Met Lys Val Leu Ile Leu Ala Cys Leu Val Ala Leu Ala 
        35                  40                  45              


Leu Ala Arg Glu Leu Glu Glu Leu Asn Val Pro Gly Glu Ile Val Glu 
    50                  55                  60                  


Ser Leu Ser Ser Ser Glu Glu Ser Ile Thr Arg Ile Asn Lys Lys Ile 
65                  70                  75                  80  


Glu Lys Phe Gln Ser Glu Glu Gln Gln Gln Thr Glu Asp Glu Leu Gln 
                85                  90                  95      


Asp Lys Ile His Pro Phe Ala Gln Thr Gln Ser Leu Val Tyr Pro Phe 
            100                 105                 110         


Pro Gly Pro Ile His Asn Ser Leu Pro Gln Asn Ile Pro Pro Leu Thr 
        115                 120                 125             


Gln Thr Pro Val Val Val Pro Pro Phe Leu Gln Pro Glu Val Met Gly 
    130                 135                 140                 


Val Ser Lys Val Lys Glu Ala Met Ala Pro Lys His Lys Glu Met Pro 
145                 150                 155                 160 


Phe Pro Lys Tyr Pro Val Glu Pro Phe Thr Glu Arg Gln Ser Leu Thr 
                165                 170                 175     


Leu Thr Asp Val Glu Asn Leu His Leu Pro Leu Pro Leu Leu Gln Ser 
            180                 185                 190         


Trp Met His Gln Pro His Gln Pro Leu Pro Pro Thr Val Met Phe Pro 
        195                 200                 205             


Pro Gln Ser Val Leu Ser Leu Ser Gln Ser Lys Val Leu Pro Val Pro 
    210                 215                 220                 


Gln Lys Ala Val Pro Tyr Pro Gln Arg Asp Met Pro Ile Gln Ala Phe 
225                 230                 235                 240 


Leu Leu Tyr Gln Glu Pro Val Leu Gly Pro Val Arg Gly Pro Phe Pro 
                245                 250                 255     


Ile Ile Val 
            


<210>  20
<211>  216
<212>  PRT
<213>  Bos taurus

<400>  20

Met Lys Val Leu Ile Leu Ala Cys Leu Val Ala Leu Ala Leu Ala Arg 
1               5                   10                  15      


Glu Leu Glu Glu Leu Asn Val Pro Gly Glu Ile Val Glu Ser Leu Ser 
            20                  25                  30          


Ser Ser Glu Lys Ile Glu Lys Phe Gln Ser Glu Glu Gln Gln Gln Thr 
        35                  40                  45              


Glu Asp Glu Leu Gln Asp Lys Ile His Pro Phe Ala Gln Thr Gln Ser 
    50                  55                  60                  


Leu Val Tyr Pro Phe Pro Gly Pro Ile His Asn Ser Leu Pro Gln Asn 
65                  70                  75                  80  


Ile Pro Pro Leu Thr Gln Thr Pro Val Val Val Pro Pro Phe Leu Gln 
                85                  90                  95      


Pro Glu Val Met Gly Val Ser Lys Val Lys Glu Ala Met Ala Pro Lys 
            100                 105                 110         


His Lys Glu Met Pro Phe Pro Lys Tyr Pro Val Glu Pro Phe Thr Glu 
        115                 120                 125             


Arg Gln Ser Leu Thr Leu Thr Asp Val Glu Asn Leu His Leu Pro Leu 
    130                 135                 140                 


Pro Leu Leu Gln Ser Trp Met His Gln Pro His Gln Pro Leu Pro Pro 
145                 150                 155                 160 


Thr Val Met Phe Pro Pro Gln Ser Val Leu Ser Leu Ser Gln Ser Lys 
                165                 170                 175     


Val Leu Pro Val Pro Gln Lys Ala Val Pro Tyr Pro Gln Arg Asp Met 
            180                 185                 190         


Pro Ile Gln Ala Phe Leu Leu Tyr Gln Glu Pro Val Leu Gly Pro Val 
        195                 200                 205             


Arg Gly Pro Phe Pro Ile Ile Val 
    210                 215     


<210>  21
<211>  190
<212>  PRT
<213>  Bos taurus

<400>  21

Met Met Lys Ser Phe Phe Leu Val Val Thr Ile Leu Ala Leu Thr Leu 
1               5                   10                  15      


Pro Phe Leu Gly Ala Gln Glu Gln Asn Gln Glu Gln Pro Ile Arg Cys 
            20                  25                  30          


Glu Lys Asp Glu Arg Phe Phe Ser Asp Lys Ile Ala Lys Tyr Ile Pro 
        35                  40                  45              


Ile Gln Tyr Val Leu Ser Arg Tyr Pro Ser Tyr Gly Leu Asn Tyr Tyr 
    50                  55                  60                  


Gln Gln Lys Pro Val Ala Leu Ile Asn Asn Gln Phe Leu Pro Tyr Pro 
65                  70                  75                  80  


Tyr Tyr Ala Lys Pro Ala Ala Val Arg Ser Pro Ala Gln Ile Leu Gln 
                85                  90                  95      


Trp Gln Val Leu Ser Asn Thr Val Pro Ala Lys Ser Cys Gln Ala Gln 
            100                 105                 110         


Pro Thr Thr Met Ala Arg His Pro His Pro His Leu Ser Phe Met Ala 
        115                 120                 125             


Ile Pro Pro Lys Lys Asn Gln Asp Lys Thr Glu Ile Pro Thr Ile Asn 
    130                 135                 140                 


Thr Ile Ala Ser Gly Glu Pro Thr Ser Thr Pro Thr Ile Glu Ala Val 
145                 150                 155                 160 


Glu Ser Thr Val Ala Thr Leu Glu Ala Ser Pro Glu Val Ile Glu Ser 
                165                 170                 175     


Pro Pro Glu Ile Asn Thr Val Gln Val Thr Ser Thr Ala Val 
            180                 185                 190 


