                         SEQUENCE LISTING

<110>  Silver Creek Pharmaceuticals, Inc.
 
<120>  CHIMERIC PROTEINS FOR TARGETED DELIVERY OF GROWTH FACTORS TO THE 
       GLOMERULUS

<130>  132463-010701PCT

<150>  63/216,876
<151>  2021-06-30

<160>  67    

<170>  PatentIn version 3.5

<210>  1
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala 
65                  70  


<210>  2
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  2

Gly Pro Arg Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Ala Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala 
65                  70  


<210>  3
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  3

Met Phe Pro Ala Met Pro Leu Ser Ser Leu Phe Val Asn Gly Pro Glu 
1               5                   10                  15      


Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val Cys Gly 
            20                  25                  30          


Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser 
        35                  40                  45              


Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe Arg Ser 
    50                  55                  60                  


Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala 
65                  70                  75                  80  


Lys Ser Ala 
            


<210>  4
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  4

Gly Pro Arg Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala 
65                  70  


<210>  5
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  5

Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val Cys Gly 
1               5                   10                  15      


Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser 
            20                  25                  30          


Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe Arg Ser 
        35                  40                  45              


Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala 
    50                  55                  60                  


Lys Ser Ala 
65          


<210>  6
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  6

Met Phe Pro Ala Met Pro Leu Ser Ser Leu Phe Val Asn Gly Pro Arg 
1               5                   10                  15      


Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val Cys Gly 
            20                  25                  30          


Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser 
        35                  40                  45              


Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe Arg Ser 
    50                  55                  60                  


Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala 
65                  70                  75                  80  


Lys Ser Ala 
            


<210>  7
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  7

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys 
    50                  55                  60                  


Pro Ala Lys Ser Ala 
65                  


<210>  8
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  8

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala 
65          


<210>  9
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  9

Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210>  10
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  10

Gly His Phe Lys Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe 
1               5                   10                  15      


Phe Leu Arg Ile His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys 
            20                  25                  30          


Ser Asp Pro His Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val 
        35                  40                  45              


Val Ser Ile Lys Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu 
    50                  55                  60                  


Asp Gly Arg Leu Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe Phe 
65                  70                  75                  80  


Phe Glu Arg Leu Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys 
                85                  90                  95      


Tyr Thr Ser Trp Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu 
            100                 105                 110         


Gly Ser Lys Thr Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met 
        115                 120                 125             


Ser Ala Lys 
    130     


<210>  11
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  11

Ala Leu Gly Glu Val Gly Asn Tyr Phe Gly Val Gln Asp Ala Val Pro 
1               5                   10                  15      


Phe Gly Asn Val Pro Val Leu Pro Val Asp Ser Pro Val Leu Leu Ser 
            20                  25                  30          


Asp His Leu Gly Gln Ser Glu Ala Gly Gly Leu Pro Arg Gly Pro Ala 
        35                  40                  45              


Val Thr Asp Leu Asp His Leu Lys Gly Ile Leu Arg Arg Arg Gln Leu 
    50                  55                  60                  


Tyr Cys Arg Thr Gly Phe His Leu Glu Ile Phe Pro Asn Gly Thr Ile 
65                  70                  75                  80  


Gln Gly Thr Arg Lys Asp His Ser Arg Phe Gly Ile Leu Glu Phe Ile 
                85                  90                  95      


Ser Ile Ala Val Gly Leu Val Ser Ile Arg Gly Val Asp Ser Gly Leu 
            100                 105                 110         


Tyr Leu Gly Met Asn Glu Lys Gly Glu Leu Tyr Gly Ser Glu Lys Leu 
        115                 120                 125             


Thr Gln Glu Cys Val Phe Arg Glu Gln Phe Glu Glu Asn Trp Tyr Asn 
    130                 135                 140                 


Thr Tyr Ser Ser Asn Leu Tyr Lys His Val Asp Thr Gly Arg Arg Tyr 
145                 150                 155                 160 


Tyr Val Ala Leu Asn Lys Asp Gly Thr Pro Arg Glu Gly Thr Arg Thr 
                165                 170                 175     


Lys Arg His Gln 
            180 


<210>  12
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  12

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210>  13
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  13

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Gln Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210>  14
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  14

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Gln Ala Gly Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Ala Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210>  15
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  15

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Gln Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210>  16
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  16

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  17
<211>  698
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Arg Leu Ala Val Gly Ala Leu Leu Val Cys Ala Val Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala Val Pro Asp Lys Thr Val Arg Trp Cys Ala Val Ser Glu 
            20                  25                  30          


His Glu Ala Thr Lys Cys Gln Ser Phe Arg Asp His Met Lys Ser Val 
        35                  40                  45              


Ile Pro Ser Asp Gly Pro Ser Val Ala Cys Val Lys Lys Ala Ser Tyr 
    50                  55                  60                  


Leu Asp Cys Ile Arg Ala Ile Ala Ala Asn Glu Ala Asp Ala Val Thr 
65                  70                  75                  80  


Leu Asp Ala Gly Leu Val Tyr Asp Ala Tyr Leu Ala Pro Asn Asn Leu 
                85                  90                  95      


Lys Pro Val Val Ala Glu Phe Tyr Gly Ser Lys Glu Asp Pro Gln Thr 
            100                 105                 110         


Phe Tyr Tyr Ala Val Ala Val Val Lys Lys Asp Ser Gly Phe Gln Met 
        115                 120                 125             


Asn Gln Leu Arg Gly Lys Lys Ser Cys His Thr Gly Leu Gly Arg Ser 
    130                 135                 140                 


Ala Gly Trp Asn Ile Pro Ile Gly Leu Leu Tyr Cys Asp Leu Pro Glu 
145                 150                 155                 160 


Pro Arg Lys Pro Leu Glu Lys Ala Val Ala Asn Phe Phe Ser Gly Ser 
                165                 170                 175     


Cys Ala Pro Cys Ala Asp Gly Thr Asp Phe Pro Gln Leu Cys Gln Leu 
            180                 185                 190         


Cys Pro Gly Cys Gly Cys Ser Thr Leu Asn Gln Tyr Phe Gly Tyr Ser 
        195                 200                 205             


Gly Ala Phe Lys Cys Leu Lys Asp Gly Ala Gly Asp Val Ala Phe Val 
    210                 215                 220                 


Lys His Ser Thr Ile Phe Glu Asn Leu Ala Asn Lys Ala Asp Arg Asp 
225                 230                 235                 240 


Gln Tyr Glu Leu Leu Cys Leu Asp Asn Thr Arg Lys Pro Val Asp Glu 
                245                 250                 255     


Tyr Lys Asp Cys His Leu Ala Gln Val Pro Ser His Thr Val Val Ala 
            260                 265                 270         


Arg Ser Met Gly Gly Lys Glu Asp Leu Ile Trp Glu Leu Leu Asn Gln 
        275                 280                 285             


Ala Gln Glu His Phe Gly Lys Asp Lys Ser Lys Glu Phe Gln Leu Phe 
    290                 295                 300                 


Ser Ser Pro His Gly Lys Asp Leu Leu Phe Lys Asp Ser Ala His Gly 
305                 310                 315                 320 


Phe Leu Lys Val Pro Pro Arg Met Asp Ala Lys Met Tyr Leu Gly Tyr 
                325                 330                 335     


Glu Tyr Val Thr Ala Ile Arg Asn Leu Arg Glu Gly Thr Cys Pro Glu 
            340                 345                 350         


Ala Pro Thr Asp Glu Cys Lys Pro Val Lys Trp Cys Ala Leu Ser His 
        355                 360                 365             


His Glu Arg Leu Lys Cys Asp Glu Trp Ser Val Asn Ser Val Gly Lys 
    370                 375                 380                 


Ile Glu Cys Val Ser Ala Glu Thr Thr Glu Asp Cys Ile Ala Lys Ile 
385                 390                 395                 400 


Met Asn Gly Glu Ala Asp Ala Met Ser Leu Asp Gly Gly Phe Val Tyr 
                405                 410                 415     


Ile Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala Glu Asn Tyr Asn 
            420                 425                 430         


Lys Ser Asp Asn Cys Glu Asp Thr Pro Glu Ala Gly Tyr Phe Ala Ile 
        435                 440                 445             


Ala Val Val Lys Lys Ser Ala Ser Asp Leu Thr Trp Asp Asn Leu Lys 
    450                 455                 460                 


Gly Lys Lys Ser Cys His Thr Ala Val Gly Arg Thr Ala Gly Trp Asn 
465                 470                 475                 480 


Ile Pro Met Gly Leu Leu Tyr Asn Lys Ile Asn His Cys Arg Phe Asp 
                485                 490                 495     


Glu Phe Phe Ser Glu Gly Cys Ala Pro Gly Ser Lys Lys Asp Ser Ser 
            500                 505                 510         


Leu Cys Lys Leu Cys Met Gly Ser Gly Leu Asn Leu Cys Glu Pro Asn 
        515                 520                 525             


Asn Lys Glu Gly Tyr Tyr Gly Tyr Thr Gly Ala Phe Arg Cys Leu Val 
    530                 535                 540                 


Glu Lys Gly Asp Val Ala Phe Val Lys His Gln Thr Val Pro Gln Asn 
545                 550                 555                 560 


Thr Gly Gly Lys Asn Pro Asp Pro Trp Ala Lys Asn Leu Asn Glu Lys 
                565                 570                 575     


Asp Tyr Glu Leu Leu Cys Leu Asp Gly Thr Arg Lys Pro Val Glu Glu 
            580                 585                 590         


Tyr Ala Asn Cys His Leu Ala Arg Ala Pro Asn His Ala Val Val Thr 
        595                 600                 605             


Arg Lys Asp Lys Glu Ala Cys Val His Lys Ile Leu Arg Gln Gln Gln 
    610                 615                 620                 


His Leu Phe Gly Ser Asn Val Thr Asp Cys Ser Gly Asn Phe Cys Leu 
625                 630                 635                 640 


Phe Arg Ser Glu Thr Lys Asp Leu Leu Phe Arg Asp Asp Thr Val Cys 
                645                 650                 655     


Leu Ala Lys Leu His Asp Arg Asn Thr Tyr Glu Lys Tyr Leu Gly Glu 
            660                 665                 670         


Glu Tyr Val Lys Ala Val Gly Asn Leu Arg Lys Cys Ser Thr Ser Ser 
        675                 680                 685             


Leu Leu Glu Ala Cys Thr Phe Arg Arg Pro 
    690                 695             


<210>  18
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Lys Trp Val Glu Ser Ile Phe Leu Ile Phe Leu Leu Asn Phe Thr 
1               5                   10                  15      


Glu Ser Arg Thr Leu His Arg Asn Glu Tyr Gly Ile Ala Ser Ile Leu 
            20                  25                  30          


Asp Ser Tyr Gln Cys Thr Ala Glu Ile Ser Leu Ala Asp Leu Ala Thr 
        35                  40                  45              


Ile Phe Phe Ala Gln Phe Val Gln Glu Ala Thr Tyr Lys Glu Val Ser 
    50                  55                  60                  


Lys Met Val Lys Asp Ala Leu Thr Ala Ile Glu Lys Pro Thr Gly Asp 
65                  70                  75                  80  


Glu Gln Ser Ser Gly Cys Leu Glu Asn Gln Leu Pro Ala Phe Leu Glu 
                85                  90                  95      


Glu Leu Cys His Glu Lys Glu Ile Leu Glu Lys Tyr Gly His Ser Asp 
            100                 105                 110         


Cys Cys Ser Gln Ser Glu Glu Gly Arg His Asn Cys Phe Leu Ala His 
        115                 120                 125             


Lys Lys Pro Thr Pro Ala Ser Ile Pro Leu Phe Gln Val Pro Glu Pro 
    130                 135                 140                 


Val Thr Ser Cys Glu Ala Tyr Glu Glu Asp Arg Glu Thr Phe Met Asn 
145                 150                 155                 160 


Lys Phe Ile Tyr Glu Ile Ala Arg Arg His Pro Phe Leu Tyr Ala Pro 
                165                 170                 175     


Thr Ile Leu Leu Trp Ala Ala Arg Tyr Asp Lys Ile Ile Pro Ser Cys 
            180                 185                 190         


Cys Lys Ala Glu Asn Ala Val Glu Cys Phe Gln Thr Lys Ala Ala Thr 
        195                 200                 205             


Val Thr Lys Glu Leu Arg Glu Ser Ser Leu Leu Asn Gln His Ala Cys 
    210                 215                 220                 


Ala Val Met Lys Asn Phe Gly Thr Arg Thr Phe Gln Ala Ile Thr Val 
225                 230                 235                 240 


Thr Lys Leu Ser Gln Lys Phe Thr Lys Val Asn Phe Thr Glu Ile Gln 
                245                 250                 255     


Lys Leu Val Leu Asp Val Ala His Val His Glu His Cys Cys Arg Gly 
            260                 265                 270         


Asp Val Leu Asp Cys Leu Gln Asp Gly Glu Lys Ile Met Ser Tyr Ile 
        275                 280                 285             


Cys Ser Gln Gln Asp Thr Leu Ser Asn Lys Ile Thr Glu Cys Cys Lys 
    290                 295                 300                 


Leu Thr Thr Leu Glu Arg Gly Gln Cys Ile Ile His Ala Glu Asn Asp 
305                 310                 315                 320 


Glu Lys Pro Glu Gly Leu Ser Pro Asn Leu Asn Arg Phe Leu Gly Asp 
                325                 330                 335     


Arg Asp Phe Asn Gln Phe Ser Ser Gly Glu Lys Asn Ile Phe Leu Ala 
            340                 345                 350         


Ser Phe Val His Glu Tyr Ser Arg Arg His Pro Gln Leu Ala Val Ser 
        355                 360                 365             


Val Ile Leu Arg Val Ala Lys Gly Tyr Gln Glu Leu Leu Glu Lys Cys 
    370                 375                 380                 


Phe Gln Thr Glu Asn Pro Leu Glu Cys Gln Asp Lys Gly Glu Glu Glu 
385                 390                 395                 400 


Leu Gln Lys Tyr Ile Gln Glu Ser Gln Ala Leu Ala Lys Arg Ser Cys 
                405                 410                 415     


Gly Leu Phe Gln Lys Leu Gly Glu Tyr Tyr Leu Gln Asn Ala Phe Leu 
            420                 425                 430         


Val Ala Tyr Thr Lys Lys Ala Pro Gln Leu Thr Ser Ser Glu Leu Met 
        435                 440                 445             


Ala Ile Thr Arg Lys Met Ala Ala Thr Ala Ala Thr Cys Cys Gln Leu 
    450                 455                 460                 


Ser Glu Asp Lys Leu Leu Ala Cys Gly Glu Gly Ala Ala Asp Ile Ile 
465                 470                 475                 480 


Ile Gly His Leu Cys Ile Arg His Glu Met Thr Pro Val Asn Pro Gly 
                485                 490                 495     


Val Gly Gln Cys Cys Thr Ser Ser Tyr Ala Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ser Leu Val Val Asp Glu Thr Tyr Val Pro Pro Ala Phe Ser Asp 
        515                 520                 525             


Asp Lys Phe Ile Phe His Lys Asp Leu Cys Gln Ala Gln Gly Val Ala 
    530                 535                 540                 


Leu Gln Thr Met Lys Gln Glu Phe Leu Ile Asn Leu Val Lys Gln Lys 
545                 550                 555                 560 


Pro Gln Ile Thr Glu Glu Gln Leu Glu Ala Val Ile Ala Asp Phe Ser 
                565                 570                 575     


Gly Leu Leu Glu Lys Cys Cys Gln Gly Gln Glu Gln Glu Val Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Gln Lys Leu Ile Ser Lys Thr Arg Ala Ala Leu Gly 
        595                 600                 605             


Val 
    


<210>  19
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Lys Arg Val Leu Val Leu Leu Leu Ala Val Ala Phe Gly His Ala 
1               5                   10                  15      


Leu Glu Arg Gly Arg Asp Tyr Glu Lys Asn Lys Val Cys Lys Glu Phe 
            20                  25                  30          


Ser His Leu Gly Lys Glu Asp Phe Thr Ser Leu Ser Leu Val Leu Tyr 
        35                  40                  45              


Ser Arg Lys Phe Pro Ser Gly Thr Phe Glu Gln Val Ser Gln Leu Val 
    50                  55                  60                  


Lys Glu Val Val Ser Leu Thr Glu Ala Cys Cys Ala Glu Gly Ala Asp 
65                  70                  75                  80  


Pro Asp Cys Tyr Asp Thr Arg Thr Ser Ala Leu Ser Ala Lys Ser Cys 
                85                  90                  95      


Glu Ser Asn Ser Pro Phe Pro Val His Pro Gly Thr Ala Glu Cys Cys 
            100                 105                 110         


Thr Lys Glu Gly Leu Glu Arg Lys Leu Cys Met Ala Ala Leu Lys His 
        115                 120                 125             


Gln Pro Gln Glu Phe Pro Thr Tyr Val Glu Pro Thr Asn Asp Glu Ile 
    130                 135                 140                 


Cys Glu Ala Phe Arg Lys Asp Pro Lys Glu Tyr Ala Asn Gln Phe Met 
145                 150                 155                 160 


Trp Glu Tyr Ser Thr Asn Tyr Gly Gln Ala Pro Leu Ser Leu Leu Val 
                165                 170                 175     


Ser Tyr Thr Lys Ser Tyr Leu Ser Met Val Gly Ser Cys Cys Thr Ser 
            180                 185                 190         


Ala Ser Pro Thr Val Cys Phe Leu Lys Glu Arg Leu Gln Leu Lys His 
        195                 200                 205             


Leu Ser Leu Leu Thr Thr Leu Ser Asn Arg Val Cys Ser Gln Tyr Ala 
    210                 215                 220                 


Ala Tyr Gly Glu Lys Lys Ser Arg Leu Ser Asn Leu Ile Lys Leu Ala 
225                 230                 235                 240 


Gln Lys Val Pro Thr Ala Asp Leu Glu Asp Val Leu Pro Leu Ala Glu 
                245                 250                 255     


Asp Ile Thr Asn Ile Leu Ser Lys Cys Cys Glu Ser Ala Ser Glu Asp 
            260                 265                 270         


Cys Met Ala Lys Glu Leu Pro Glu His Thr Val Lys Leu Cys Asp Asn 
        275                 280                 285             


Leu Ser Thr Lys Asn Ser Lys Phe Glu Asp Cys Cys Gln Glu Lys Thr 
    290                 295                 300                 


Ala Met Asp Val Phe Val Cys Thr Tyr Phe Met Pro Ala Ala Gln Leu 
305                 310                 315                 320 


Pro Glu Leu Pro Asp Val Glu Leu Pro Thr Asn Lys Asp Val Cys Asp 
                325                 330                 335     


Pro Gly Asn Thr Lys Val Met Asp Lys Tyr Thr Phe Glu Leu Ser Arg 
            340                 345                 350         


Arg Thr His Leu Pro Glu Val Phe Leu Ser Lys Val Leu Glu Pro Thr 
        355                 360                 365             


Leu Lys Ser Leu Gly Glu Cys Cys Asp Val Glu Asp Ser Thr Thr Cys 
    370                 375                 380                 


Phe Asn Ala Lys Gly Pro Leu Leu Lys Lys Glu Leu Ser Ser Phe Ile 
385                 390                 395                 400 


Asp Lys Gly Gln Glu Leu Cys Ala Asp Tyr Ser Glu Asn Thr Phe Thr 
                405                 410                 415     


Glu Tyr Lys Lys Lys Leu Ala Glu Arg Leu Lys Ala Lys Leu Pro Asp 
            420                 425                 430         


Ala Thr Pro Thr Glu Leu Ala Lys Leu Val Asn Lys His Ser Asp Phe 
        435                 440                 445             


Ala Ser Asn Cys Cys Ser Ile Asn Ser Pro Pro Leu Tyr Cys Asp Ser 
    450                 455                 460                 


Glu Ile Asp Ala Glu Leu Lys Asn Ile Leu 
465                 470                 


<210>  20
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Ser His Arg Leu Leu Leu Leu Cys Leu Ala Gly Leu Val Phe 
1               5                   10                  15      


Val Ser Glu Ala Gly Pro Thr Gly Thr Gly Glu Ser Lys Cys Pro Leu 
            20                  25                  30          


Met Val Lys Val Leu Asp Ala Val Arg Gly Ser Pro Ala Ile Asn Val 
        35                  40                  45              


Ala Val His Val Phe Arg Lys Ala Ala Asp Asp Thr Trp Glu Pro Phe 
    50                  55                  60                  


Ala Ser Gly Lys Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Thr 
65                  70                  75                  80  


Glu Glu Glu Phe Val Glu Gly Ile Tyr Lys Val Glu Ile Asp Thr Lys 
                85                  90                  95      


Ser Tyr Trp Lys Ala Leu Gly Ile Ser Pro Phe His Glu His Ala Glu 
            100                 105                 110         


Val Val Phe Thr Ala Asn Asp Ser Gly Pro Arg Arg Tyr Thr Ile Ala 
        115                 120                 125             


Ala Leu Leu Ser Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Thr Asn 
    130                 135                 140                 


Pro Lys Glu 
145         


<210>  21
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  21

Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro 
1               5                   10                  15      


Ser Ala Pro Ala 
            20  


<210>  22
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  22

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Ser Gln 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Met Trp Arg Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Ala Ala Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  23

Gly Ser Gly Gly Gly Ser Gly 
1               5           


<210>  24
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  24

Lys Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala Tyr Tyr Lys Gln 
            20                  25                  30          


Gly Asp Tyr Gln Lys Ala Ile Glu Tyr Tyr Gln Lys Ala Leu Glu Leu 
        35                  40                  45              


Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala Tyr Tyr 
    50                  55                  60                  


Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu Tyr Tyr Gln Lys Ala Leu 
65                  70                  75                  80  


Glu Leu Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala 
                85                  90                  95      


Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu Asp Tyr Gln Lys 
            100                 105                 110         


Ala Leu Glu Leu Asp Pro Asn Asn Leu Gln Arg Ser Ala Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Ser 
    130                 135                 140     


<210>  25
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  25

Gly Pro Arg Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Leu Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala 
65                  70  


<210>  26
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  26

Gly Pro Arg Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Leu Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Leu Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala 
65                  70  


<210>  27
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  27

Gly Pro Arg Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Leu Phe Asn Lys Pro Thr Gly Ala Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala 
65                  70  


<210>  28
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  28

Gly Pro Arg Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Leu Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Leu Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala 
65                  70  


<210>  29
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  29

Gly Pro Arg Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Ala Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Leu Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala 
65                  70  


<210>  30
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  30

Gly Pro Arg Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Leu Phe Asn Lys Pro Thr Gly Ala Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Leu Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala 
65                  70  


<210>  31
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  31

Gly Thr Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys 
1               5                   10                  15      


Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser 
            20                  25                  30          


Arg Tyr Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln 
        35                  40                  45              


Asn Tyr Val Met Ala Ser Phe Tyr Lys His Leu Gly Ile Glu Phe Met 
    50                  55                  60                  


Glu Ala Glu Glu Leu Tyr Gln Lys 
65                  70          


<210>  32
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  32

Ser Thr Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys 
1               5                   10                  15      


Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser 
            20                  25                  30          


Arg Tyr Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln 
        35                  40                  45              


Asn Tyr Val Met Ala Ser Phe Tyr Lys His Leu Gly Ile Glu Phe Met 
    50                  55                  60                  


Glu Ala Glu Glu Leu Tyr Gln Lys 
65                  70          


<210>  33
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  33

Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe 
1               5                   10                  15      


Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro 
            20                  25                  30          


Ser Arg Tyr Leu Cys Lys Cys Gln Pro Gly Phe Thr Gly Ala Arg Cys 
        35                  40                  45              


Thr Glu Asn Val Pro Met Lys Val Gln Asn Gln Glu Lys Ala Glu Glu 
    50                  55                  60                  


Leu Tyr Gln Lys 
65              


<210>  34
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  34

Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe 
1               5                   10                  15      


Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro 
            20                  25                  30          


Ser Arg Tyr Leu Cys Lys Cys Gln Pro Gly Phe Thr Gly Ala Arg Cys 
        35                  40                  45              


Thr Glu Asn Val Pro Met Lys Val Gln Asn Gln Glu Lys His Leu Gly 
    50                  55                  60                  


Ile Glu Phe Ile Glu Ala Glu Glu Leu Tyr Gln Lys 
65                  70                  75      


<210>  35
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  35

Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe 
1               5                   10                  15      


Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro 
            20                  25                  30          


Ser Arg Tyr Leu Cys Lys Cys Gln Pro Gly Phe Thr Gly Ala Arg Cys 
        35                  40                  45              


Thr Glu Asn Val Pro Met Lys Val Gln Asn Gln Glu Ser Ala Gln Met 
    50                  55                  60                  


Ser Leu Leu Val Ile Ala Ala Lys Thr Thr 
65                  70                  


<210>  36
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  36

Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe 
1               5                   10                  15      


Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro 
            20                  25                  30          


Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys 
        35                  40                  45              


Gln Asn Tyr Val Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60                  


Lys 
65  


<210>  37
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  37

Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe 
1               5                   10                  15      


Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro 
            20                  25                  30          


Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys 
        35                  40                  45              


Gln Asn Tyr Val Met Ala Ser Phe Tyr Ser Thr Ser Thr Pro Phe Leu 
    50                  55                  60                  


Ser Leu Pro Glu 
65              


<210>  38
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  38

Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg 
1               5                   10                  15      


His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile 
            20                  25                  30          


Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro 
        35                  40                  45              


Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln 
    50                  55                  60                  


Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val 
65                  70                  75                  80  


Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu 
                85                  90                  95      


Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly 
            100                 105                 110         


Cys Arg 
        


<210>  39
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  39

Ser Thr Gly Ser Lys Gln Arg Ser Gln Asn Arg Ser Lys Thr Pro Lys 
1               5                   10                  15      


Asn Gln Glu Ala Leu Arg Met Ala Asn Val Ala Glu Asn Ser Ser Ser 
            20                  25                  30          


Asp Gln Arg Gln Ala Cys Lys Lys His Glu Leu Tyr Val Ser Phe Arg 
        35                  40                  45              


Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala Pro Glu Gly Tyr Ala Ala 
    50                  55                  60                  


Tyr Tyr Cys Glu Gly Glu Cys Ala Phe Pro Leu Asn Ser Tyr Met Asn 
65                  70                  75                  80  


Ala Thr Asn His Ala Ile Val Gln Thr Leu Val His Phe Ile Asn Pro 
                85                  90                  95      


Glu Thr Val Pro Lys Pro Cys Cys Ala Pro Thr Gln Leu Asn Ala Ile 
            100                 105                 110         


Ser Val Leu Tyr Phe Asp Asp Ser Ser Asn Val Ile Leu Lys Lys Tyr 
        115                 120                 125             


Arg Asn Met Val Val Arg Ala Cys Gly Cys His 
    130                 135                 


<210>  40
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  40

Thr Gly Ala Pro Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val 
1               5                   10                  15      


Val Lys Phe Met Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu 
            20                  25                  30          


Thr Leu Val Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile 
        35                  40                  45              


Phe Lys Pro Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn 
    50                  55                  60                  


Asp Glu Gly Leu Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met 
65                  70                  75                  80  


Gln Ile Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met 
                85                  90                  95      


Ser Phe Leu Gln His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg 
            100                 105                 110         


Ala Arg 
        


<210>  41
<211>  1080
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  41

Gly Pro Arg Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Ala Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala Gly Ser Gly Gly Gly Ser Gly Asp Ala His 
65                  70                  75                  80  


Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe 
                85                  90                  95      


Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro 
            100                 105                 110         


Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys 
        115                 120                 125             


Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His 
    130                 135                 140                 


Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr 
145                 150                 155                 160 


Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn 
                165                 170                 175     


Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu 
            180                 185                 190         


Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu 
        195                 200                 205             


Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro 
    210                 215                 220                 


Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala 
225                 230                 235                 240 


Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu 
                245                 250                 255     


Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys 
            260                 265                 270         


Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe 
        275                 280                 285             


Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu 
    290                 295                 300                 


Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr 
305                 310                 315                 320 


Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp 
                325                 330                 335     


Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu 
            340                 345                 350         


Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala 
        355                 360                 365             


Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala 
    370                 375                 380                 


Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys 
385                 390                 395                 400 


Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro 
                405                 410                 415     


Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr 
            420                 425                 430         


Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala 
        435                 440                 445             


Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu 
    450                 455                 460                 


Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe 
465                 470                 475                 480 


Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser 
                485                 490                 495     


Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser 
            500                 505                 510         


Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp 
        515                 520                 525             


Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr 
    530                 535                 540                 


Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn 
545                 550                 555                 560 


Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro 
                565                 570                 575     


Lys Glu Phe Gln Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr 
            580                 585                 590         


Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu 
        595                 600                 605             


Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val 
    610                 615                 620                 


Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp 
625                 630                 635                 640 


Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser 
                645                 650                 655     


Gln Ala Ala Leu Gly Leu Lys Leu Ser Gly Gly Gly Gly Ser Gly Gly 
            660                 665                 670         


Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ala Trp Tyr Asn Leu Gly 
        675                 680                 685             


Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu Tyr Tyr 
    690                 695                 700                 


Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn 
705                 710                 715                 720 


Leu Gly Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu 
                725                 730                 735     


Tyr Tyr Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn Ala Glu Ala Trp 
            740                 745                 750         


Tyr Asn Leu Gly Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala 
        755                 760                 765             


Ile Glu Asp Tyr Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn Leu Gln 
    770                 775                 780                 


Arg Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
785                 790                 795                 800 


Gly Ala Ser Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly 
                805                 810                 815     


Gly Thr Val Glu Ile Thr Cys Ser Gly Gly Gly Arg Tyr Tyr Asp Gly 
            820                 825                 830         


Ser Tyr Tyr Tyr Gly Trp Tyr Gln Gln Lys Ser Pro Gly Ser Ala Pro 
        835                 840                 845             


Val Thr Val Ile Tyr Glu Asn Thr Lys Arg Pro Ser Asn Ile Pro Ser 
    850                 855                 860                 


Arg Phe Ser Gly Ser Lys Ser Gly Ser Thr Ala Thr Leu Thr Ile Thr 
865                 870                 875                 880 


Gly Val Arg Ala Glu Asp Glu Ala Val Tyr Tyr Cys Gly Ser Ala Asp 
                885                 890                 895     


Asp Asn Met Asn Pro Thr Ile Phe Gly Ala Gly Thr Thr Leu Thr Val 
            900                 905                 910         


Leu Gly Gly Ser Ser Arg Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        915                 920                 925             


Gly Ser Ser Ala Leu Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr 
    930                 935                 940                 


Pro Gly Gly Ala Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe 
945                 950                 955                 960 


Ser Ser Tyr Gly Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                965                 970                 975     


Glu Trp Val Ala Gly Ile Gln Asn Asp Asp Thr Gly Thr Tyr Tyr Gly 
            980                 985                 990         


Ala Ala Val Lys Gly Arg Ala Thr  Ile Ser Arg Asp Asn  Gly Gln Ser 
        995                 1000                 1005             


Thr Val  Arg Leu Gln Leu Asn  Asn Leu Arg Ala Glu  Asp Thr Gly 
    1010                 1015                 1020             


Thr Tyr  Tyr Cys Ala Lys Asp  Ala Ser Ser Asp Gly  Gly Tyr Gly 
    1025                 1030                 1035             


Gly Asp  Ser Ile Asp Ala Trp  Gly His Gly Thr Glu  Val Ile Val 
    1040                 1045                 1050             


Ser Ser  Thr Ser Gly Gln Ala  Gly Gln His His His  His His His 
    1055                 1060                 1065             


Gly Ala  Tyr Pro Tyr Asp Val  Pro Asp Tyr Ala Ser  
    1070                 1075                 1080 


<210>  42
<211>  1051
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  42

Gly Pro Arg Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Ala Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala Gly Ser Gly Gly Gly Ser Gly Asp Ala His 
65                  70                  75                  80  


Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe 
                85                  90                  95      


Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro 
            100                 105                 110         


Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys 
        115                 120                 125             


Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His 
    130                 135                 140                 


Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr 
145                 150                 155                 160 


Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn 
                165                 170                 175     


Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu 
            180                 185                 190         


Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu 
        195                 200                 205             


Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro 
    210                 215                 220                 


Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala 
225                 230                 235                 240 


Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu 
                245                 250                 255     


Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys 
            260                 265                 270         


Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe 
        275                 280                 285             


Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu 
    290                 295                 300                 


Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr 
305                 310                 315                 320 


Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp 
                325                 330                 335     


Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu 
            340                 345                 350         


Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala 
        355                 360                 365             


Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala 
    370                 375                 380                 


Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys 
385                 390                 395                 400 


Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro 
                405                 410                 415     


Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr 
            420                 425                 430         


Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala 
        435                 440                 445             


Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu 
    450                 455                 460                 


Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe 
465                 470                 475                 480 


Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser 
                485                 490                 495     


Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser 
            500                 505                 510         


Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp 
        515                 520                 525             


Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr 
    530                 535                 540                 


Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn 
545                 550                 555                 560 


Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro 
                565                 570                 575     


Lys Glu Phe Gln Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr 
            580                 585                 590         


Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu 
        595                 600                 605             


Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val 
    610                 615                 620                 


Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp 
625                 630                 635                 640 


Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser 
                645                 650                 655     


Gln Ala Ala Leu Gly Leu Lys Leu Ser Gly Gly Gly Gly Ser Gly Gly 
            660                 665                 670         


Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ala Trp Tyr Asn Leu Gly 
        675                 680                 685             


Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu Tyr Tyr 
    690                 695                 700                 


Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn 
705                 710                 715                 720 


Leu Gly Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu 
                725                 730                 735     


Tyr Tyr Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn Ala Glu Ala Trp 
            740                 745                 750         


Tyr Asn Leu Gly Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala 
        755                 760                 765             


Ile Glu Asp Tyr Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn Leu Gln 
    770                 775                 780                 


Arg Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
785                 790                 795                 800 


Gly Ala Ser Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln 
                805                 810                 815     


Pro Gly Arg Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe 
            820                 825                 830         


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
        835                 840                 845             


Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala 
    850                 855                 860                 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
865                 870                 875                 880 


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
                885                 890                 895     


Tyr Tyr Cys Ala Lys Pro Leu Gly Asp Leu Tyr Val Asn Asp Ala Phe 
            900                 905                 910         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
        915                 920                 925             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
    930                 935                 940                 


Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln Arg Val Thr Ile 
945                 950                 955                 960 


Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
                965                 970                 975     


Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Met Ile Tyr Glu 
            980                 985                 990         


Val Ser Asn Arg Pro Ser Gly Val  Ser Asn Arg Phe Ser  Gly Ser Lys 
        995                 1000                 1005             


Ser Gly  Asn Thr Ala Ser Leu  Thr Ile Ser Gly Leu  Gln Thr Glu 
    1010                 1015                 1020             


Asp Glu  Ala Tyr Tyr Tyr Cys  Ser Ser Tyr Ala Ser  Gly Asn Ile 
    1025                 1030                 1035             


Val Val  Phe Gly Gly Gly Thr  Lys Leu Thr Val Leu  Gly 
    1040                 1045                 1050     


<210>  43
<211>  1044
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  43

Gly Pro Arg Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Ala Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala Gly Ser Gly Gly Gly Ser Gly Asp Ala His 
65                  70                  75                  80  


Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe 
                85                  90                  95      


Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro 
            100                 105                 110         


Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys 
        115                 120                 125             


Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His 
    130                 135                 140                 


Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr 
145                 150                 155                 160 


Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn 
                165                 170                 175     


Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu 
            180                 185                 190         


Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu 
        195                 200                 205             


Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro 
    210                 215                 220                 


Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala 
225                 230                 235                 240 


Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu 
                245                 250                 255     


Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys 
            260                 265                 270         


Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe 
        275                 280                 285             


Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu 
    290                 295                 300                 


Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr 
305                 310                 315                 320 


Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp 
                325                 330                 335     


Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu 
            340                 345                 350         


Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala 
        355                 360                 365             


Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala 
    370                 375                 380                 


Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys 
385                 390                 395                 400 


Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro 
                405                 410                 415     


Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr 
            420                 425                 430         


Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala 
        435                 440                 445             


Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu 
    450                 455                 460                 


Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe 
465                 470                 475                 480 


Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser 
                485                 490                 495     


Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser 
            500                 505                 510         


Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp 
        515                 520                 525             


Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr 
    530                 535                 540                 


Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn 
545                 550                 555                 560 


Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro 
                565                 570                 575     


Lys Glu Phe Gln Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr 
            580                 585                 590         


Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu 
        595                 600                 605             


Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val 
    610                 615                 620                 


Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp 
625                 630                 635                 640 


Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser 
                645                 650                 655     


Gln Ala Ala Leu Gly Leu Lys Leu Ser Gly Gly Gly Gly Ser Gly Gly 
            660                 665                 670         


Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ala Trp Tyr Asn Leu Gly 
        675                 680                 685             


Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu Tyr Tyr 
    690                 695                 700                 


Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn 
705                 710                 715                 720 


Leu Gly Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu 
                725                 730                 735     


Tyr Tyr Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn Ala Glu Ala Trp 
            740                 745                 750         


Tyr Asn Leu Gly Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala 
        755                 760                 765             


Ile Glu Asp Tyr Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn Leu Gln 
    770                 775                 780                 


Arg Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
785                 790                 795                 800 


Gly Ala Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
                805                 810                 815     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe 
            820                 825                 830         


Arg Ser Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
        835                 840                 845             


Glu Trp Val Ala Tyr Ile Thr Asn Ser Ser Ser Thr Ile Leu Tyr Ala 
    850                 855                 860                 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn 
865                 870                 875                 880 


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val 
                885                 890                 895     


Tyr Tyr Cys Ala Thr Ala Lys Leu Asp His Trp Gly Gln Gly Thr Leu 
            900                 905                 910         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        915                 920                 925             


Gly Gly Gly Ser His Val Ile Leu Thr Gln Pro Pro Ser Val Ser Gly 
    930                 935                 940                 


Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn 
945                 950                 955                 960 


Ile Gly Ala Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr 
                965                 970                 975     


Ala Pro Lys Leu Leu Ile Tyr Arg Asn Ser Asn Arg Pro Ser Gly Val 
            980                 985                 990         


Pro Asp Arg Phe Ser Gly Ser Lys  Ser Gly Ser Ser Ala  Ser Leu Ala 
        995                 1000                 1005             


Ile Thr  Gly Leu Gln Ala Glu  Asp Glu Ala Asp Tyr  Tyr Cys Gln 
    1010                 1015                 1020             


Ser Tyr  Asp Asn Ser Leu Thr  Ala Leu Val Phe Gly  Gly Gly Thr 
    1025                 1030                 1035             


Lys Val  Thr Val Leu Gly 
    1040                 


<210>  44
<211>  1064
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  44

Gly Pro Arg Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Ala Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala Gly Ser Gly Gly Gly Ser Gly Asp Ala His 
65                  70                  75                  80  


Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe 
                85                  90                  95      


Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro 
            100                 105                 110         


Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys 
        115                 120                 125             


Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His 
    130                 135                 140                 


Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr 
145                 150                 155                 160 


Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn 
                165                 170                 175     


Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu 
            180                 185                 190         


Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu 
        195                 200                 205             


Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro 
    210                 215                 220                 


Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala 
225                 230                 235                 240 


Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu 
                245                 250                 255     


Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys 
            260                 265                 270         


Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe 
        275                 280                 285             


Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu 
    290                 295                 300                 


Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr 
305                 310                 315                 320 


Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp 
                325                 330                 335     


Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu 
            340                 345                 350         


Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala 
        355                 360                 365             


Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala 
    370                 375                 380                 


Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys 
385                 390                 395                 400 


Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro 
                405                 410                 415     


Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr 
            420                 425                 430         


Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala 
        435                 440                 445             


Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu 
    450                 455                 460                 


Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe 
465                 470                 475                 480 


Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser 
                485                 490                 495     


Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser 
            500                 505                 510         


Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp 
        515                 520                 525             


Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr 
    530                 535                 540                 


Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn 
545                 550                 555                 560 


Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro 
                565                 570                 575     


Lys Glu Phe Gln Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr 
            580                 585                 590         


Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu 
        595                 600                 605             


Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val 
    610                 615                 620                 


Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp 
625                 630                 635                 640 


Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser 
                645                 650                 655     


Gln Ala Ala Leu Gly Leu Lys Leu Ser Gly Gly Gly Gly Ser Gly Gly 
            660                 665                 670         


Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ala Trp Tyr Asn Leu Gly 
        675                 680                 685             


Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu Tyr Tyr 
    690                 695                 700                 


Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn 
705                 710                 715                 720 


Leu Gly Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu 
                725                 730                 735     


Tyr Tyr Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn Ala Glu Ala Trp 
            740                 745                 750         


Tyr Asn Leu Gly Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala 
        755                 760                 765             


Ile Glu Asp Tyr Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn Leu Gln 
    770                 775                 780                 


Arg Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
785                 790                 795                 800 


Gly Ala Ser Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
                805                 810                 815     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe 
            820                 825                 830         


Asn Asn Tyr Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
        835                 840                 845             


Glu Trp Val Ser Val Ile Ser Asp Gly Gly Ala Gly Thr Tyr Tyr Ala 
    850                 855                 860                 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
865                 870                 875                 880 


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
                885                 890                 895     


Tyr Tyr Cys Ala Arg Thr Ser Tyr Val Tyr Glu Tyr Gln Gln Trp Thr 
            900                 905                 910         


Arg Gly Ser Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        915                 920                 925             


Ala Ser Ser Gly Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
    930                 935                 940                 


Glu Gly Ser Ser Gly Ser Ala Arg Gln Ser Val Leu Thr Gln Pro Pro 
945                 950                 955                 960 


Ser Val Ser Gly Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly 
                965                 970                 975     


Ser Ser Ser Asn Ile Gly Ala Gly Tyr Gly Val His Trp Tyr Gln Gln 
            980                 985                 990         


Leu Pro Gly Thr Ala Pro Lys Leu  Leu Ile Tyr Gly Asn  Thr Asn Arg 
        995                 1000                 1005             


Pro Ser  Gly Val Pro Asp Arg  Phe Ser Gly Phe Lys  Ser Gly Thr 
    1010                 1015                 1020             


Ser Ala  Ser Leu Ala Ile Thr  Gly Leu Gln Ala Glu  Asp Glu Ala 
    1025                 1030                 1035             


Asp Tyr  Tyr Cys Gln Ser Tyr  Asp Ser Ser Leu Ser  Gly Trp Val 
    1040                 1045                 1050             


Phe Gly  Gly Gly Thr Lys Leu  Thr Val Leu Gly 
    1055                 1060                 


<210>  45
<211>  1056
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  45

Gly Pro Arg Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Ala Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala Gly Ser Gly Gly Gly Ser Gly Asp Ala His 
65                  70                  75                  80  


Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe 
                85                  90                  95      


Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro 
            100                 105                 110         


Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys 
        115                 120                 125             


Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His 
    130                 135                 140                 


Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr 
145                 150                 155                 160 


Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn 
                165                 170                 175     


Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu 
            180                 185                 190         


Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu 
        195                 200                 205             


Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro 
    210                 215                 220                 


Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala 
225                 230                 235                 240 


Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu 
                245                 250                 255     


Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys 
            260                 265                 270         


Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe 
        275                 280                 285             


Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu 
    290                 295                 300                 


Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr 
305                 310                 315                 320 


Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp 
                325                 330                 335     


Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu 
            340                 345                 350         


Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala 
        355                 360                 365             


Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala 
    370                 375                 380                 


Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys 
385                 390                 395                 400 


Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro 
                405                 410                 415     


Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr 
            420                 425                 430         


Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala 
        435                 440                 445             


Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu 
    450                 455                 460                 


Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe 
465                 470                 475                 480 


Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser 
                485                 490                 495     


Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser 
            500                 505                 510         


Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp 
        515                 520                 525             


Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr 
    530                 535                 540                 


Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn 
545                 550                 555                 560 


Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro 
                565                 570                 575     


Lys Glu Phe Gln Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr 
            580                 585                 590         


Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu 
        595                 600                 605             


Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val 
    610                 615                 620                 


Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp 
625                 630                 635                 640 


Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser 
                645                 650                 655     


Gln Ala Ala Leu Gly Leu Lys Leu Ser Gly Gly Gly Gly Ser Gly Gly 
            660                 665                 670         


Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ala Trp Tyr Asn Leu Gly 
        675                 680                 685             


Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu Tyr Tyr 
    690                 695                 700                 


Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn 
705                 710                 715                 720 


Leu Gly Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu 
                725                 730                 735     


Tyr Tyr Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn Ala Glu Ala Trp 
            740                 745                 750         


Tyr Asn Leu Gly Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala 
        755                 760                 765             


Ile Glu Asp Tyr Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn Leu Gln 
    770                 775                 780                 


Arg Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
785                 790                 795                 800 


Gly Ala Ser Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
                805                 810                 815     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            820                 825                 830         


Thr Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
        835                 840                 845             


Glu Trp Val Ser Gly Ile Ser Gly Gly Gly Gly Arg Thr Tyr Tyr Ala 
    850                 855                 860                 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
865                 870                 875                 880 


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
                885                 890                 895     


Tyr Tyr Cys Ala Arg Thr Pro Gly Ser Tyr Pro Phe Asp Tyr Trp Gly 
            900                 905                 910         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Ser Gly Gly Ser Thr 
        915                 920                 925             


Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Ser Gly Ser Ala 
    930                 935                 940                 


Arg Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly 
945                 950                 955                 960 


Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Asn Asp Ile Gly Ala 
                965                 970                 975     


Tyr Asp Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys 
            980                 985                 990         


Leu Met Ile Tyr Glu Val Thr Lys  Arg Pro Ser Gly Val  Ser Asn Arg 
        995                 1000                 1005             


Phe Ser  Gly Ser Lys Ser Gly  Asn Thr Ala Ser Leu  Thr Ile Ser 
    1010                 1015                 1020             


Gly Leu  Gln Ala Glu Asp Glu  Ala Asp Tyr Tyr Cys  Ser Ser Tyr 
    1025                 1030                 1035             


Thr Ser  Thr Asn Ile Phe Val  Phe Gly Gly Gly Thr  Lys Leu Thr 
    1040                 1045                 1050             


Val Leu  Gly 
    1055     


<210>  46
<211>  1044
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  46

Gly Pro Arg Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Ala Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala Gly Ser Gly Gly Gly Ser Gly Asp Ala His 
65                  70                  75                  80  


Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe 
                85                  90                  95      


Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro 
            100                 105                 110         


Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys 
        115                 120                 125             


Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His 
    130                 135                 140                 


Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr 
145                 150                 155                 160 


Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn 
                165                 170                 175     


Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu 
            180                 185                 190         


Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu 
        195                 200                 205             


Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro 
    210                 215                 220                 


Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala 
225                 230                 235                 240 


Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu 
                245                 250                 255     


Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys 
            260                 265                 270         


Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe 
        275                 280                 285             


Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu 
    290                 295                 300                 


Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr 
305                 310                 315                 320 


Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp 
                325                 330                 335     


Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu 
            340                 345                 350         


Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala 
        355                 360                 365             


Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala 
    370                 375                 380                 


Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys 
385                 390                 395                 400 


Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro 
                405                 410                 415     


Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr 
            420                 425                 430         


Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala 
        435                 440                 445             


Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu 
    450                 455                 460                 


Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe 
465                 470                 475                 480 


Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser 
                485                 490                 495     


Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser 
            500                 505                 510         


Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp 
        515                 520                 525             


Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr 
    530                 535                 540                 


Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn 
545                 550                 555                 560 


Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro 
                565                 570                 575     


Lys Glu Phe Gln Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr 
            580                 585                 590         


Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu 
        595                 600                 605             


Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val 
    610                 615                 620                 


Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp 
625                 630                 635                 640 


Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser 
                645                 650                 655     


Gln Ala Ala Leu Gly Leu Lys Leu Ser Gly Gly Gly Gly Ser Gly Gly 
            660                 665                 670         


Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ala Trp Tyr Asn Leu Gly 
        675                 680                 685             


Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu Tyr Tyr 
    690                 695                 700                 


Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn 
705                 710                 715                 720 


Leu Gly Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu 
                725                 730                 735     


Tyr Tyr Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn Ala Glu Ala Trp 
            740                 745                 750         


Tyr Asn Leu Gly Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala 
        755                 760                 765             


Ile Glu Asp Tyr Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn Leu Gln 
    770                 775                 780                 


Arg Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
785                 790                 795                 800 


Gly Ala Ser Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln 
                805                 810                 815     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            820                 825                 830         


Ser Ile Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
        835                 840                 845             


Glu Trp Val Ser Ala Ile Ser Asp Ser Gly Thr Gly Thr Tyr Tyr Ala 
    850                 855                 860                 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
865                 870                 875                 880 


Thr Leu Tyr Leu Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val 
                885                 890                 895     


Tyr Tyr Cys Ala Arg Arg Ser Gly Asn Tyr Tyr Leu Asp Tyr Trp Gly 
            900                 905                 910         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        915                 920                 925             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro 
    930                 935                 940                 


Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Arg 
945                 950                 955                 960 


Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro 
                965                 970                 975     


Gly Lys Ala Pro Lys Leu Leu Ile His Lys Thr Ser Asn Leu Glu Ser 
            980                 985                 990         


Gly Val Pro Ser Arg Phe Ser Gly  Ser Gly Ser Gly Thr  Glu Phe Ser 
        995                 1000                 1005             


Leu Thr  Ile Ser Ser Leu Gln  Pro Asp Asp Phe Ala  Thr Tyr Tyr 
    1010                 1015                 1020             


Cys Gln  Gln Tyr Tyr Ser Tyr  Pro Trp Thr Phe Gly  Arg Gly Thr 
    1025                 1030                 1035             


Lys Leu  Glu Ile Lys Arg 
    1040                 


<210>  47
<211>  662
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  47

Gly Pro Arg Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala Gly Ser Gly Gly Gly Ser Gly Asp Ala His 
65                  70                  75                  80  


Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe 
                85                  90                  95      


Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro 
            100                 105                 110         


Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys 
        115                 120                 125             


Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His 
    130                 135                 140                 


Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr 
145                 150                 155                 160 


Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn 
                165                 170                 175     


Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu 
            180                 185                 190         


Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu 
        195                 200                 205             


Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro 
    210                 215                 220                 


Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala 
225                 230                 235                 240 


Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu 
                245                 250                 255     


Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys 
            260                 265                 270         


Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe 
        275                 280                 285             


Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu 
    290                 295                 300                 


Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr 
305                 310                 315                 320 


Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp 
                325                 330                 335     


Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu 
            340                 345                 350         


Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala 
        355                 360                 365             


Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala 
    370                 375                 380                 


Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys 
385                 390                 395                 400 


Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro 
                405                 410                 415     


Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr 
            420                 425                 430         


Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala 
        435                 440                 445             


Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu 
    450                 455                 460                 


Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe 
465                 470                 475                 480 


Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser 
                485                 490                 495     


Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser 
            500                 505                 510         


Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp 
        515                 520                 525             


Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr 
    530                 535                 540                 


Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn 
545                 550                 555                 560 


Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro 
                565                 570                 575     


Lys Glu Phe Gln Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr 
            580                 585                 590         


Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu 
        595                 600                 605             


Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val 
    610                 615                 620                 


Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp 
625                 630                 635                 640 


Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser 
                645                 650                 655     


Gln Ala Ala Leu Gly Leu 
            660         


<210>  48
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  48

Ala Ala Ala Leu Ala Ala Ala 
1               5           


<210>  49
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  49

Gly Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Gly Gly Gly 
1               5                   10                  15  


<210>  50
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  50

Gly Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Ser Gly Gly Gly 
        35                  40  


<210>  51
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  51

Lys Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala Tyr Tyr Lys Gln 
            20                  25                  30          


Gly Asp Tyr Gln Lys Ala Ile Glu Tyr Tyr Gln Lys Ala Leu Glu Leu 
        35                  40                  45              


Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala Tyr Tyr 
    50                  55                  60                  


Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu Tyr Tyr Gln Lys Ala Leu 
65                  70                  75                  80  


Glu Leu Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala 
                85                  90                  95      


Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu Asp Tyr Gln Lys 
            100                 105                 110         


Ala Leu Glu Leu Asp Pro Asn Asn Leu Gln Arg Ser Ala Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Ser 
    130                 135                 140     


<210>  52
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  52

Lys Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala Tyr Tyr Lys Gln 
            20                  25                  30          


Gly Asp Tyr Gln Lys Ala Ile Glu Tyr Tyr Gln Lys Ala Leu Glu Leu 
        35                  40                  45              


Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala Tyr Tyr 
    50                  55                  60                  


Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu Tyr Tyr Gln Lys Ala Leu 
65                  70                  75                  80  


Glu Leu Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala 
                85                  90                  95      


Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu Asp Tyr Gln Lys 
            100                 105                 110         


Ala Leu Glu Leu Asp Pro Asn Asn Leu Gln Ala Glu Ala Trp Lys Asn 
        115                 120                 125             


Leu Gly Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu 
    130                 135                 140                 


Tyr Tyr Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn Ala Ser Ala Trp 
145                 150                 155                 160 


Tyr Asn Leu Gly Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala 
                165                 170                 175     


Ile Glu Tyr Tyr Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn Ala Lys 
            180                 185                 190         


Ala Trp Tyr Arg Arg Gly Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln 
        195                 200                 205             


Lys Ala Ile Glu Asp Tyr Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn 
    210                 215                 220                 


Arg Ser Arg Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ala Ser 
                245 


<210>  53
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  53

Lys Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala Tyr Tyr Lys Gln 
            20                  25                  30          


Gly Asp Tyr Gln Lys Ala Ile Glu Tyr Tyr Gln Lys Ala Leu Glu Leu 
        35                  40                  45              


Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala Tyr Tyr 
    50                  55                  60                  


Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu Tyr Tyr Gln Lys Ala Leu 
65                  70                  75                  80  


Glu Leu Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala 
                85                  90                  95      


Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu Asp Tyr Gln Lys 
            100                 105                 110         


Ala Leu Glu Leu Asp Pro Asn Asn Leu Gln Ala Glu Ala Trp Lys Asn 
        115                 120                 125             


Leu Gly Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu 
    130                 135                 140                 


Tyr Tyr Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn Ala Ser Ala Trp 
145                 150                 155                 160 


Tyr Asn Leu Gly Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala 
                165                 170                 175     


Ile Glu Tyr Tyr Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn Ala Lys 
            180                 185                 190         


Ala Trp Tyr Arg Arg Gly Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln 
        195                 200                 205             


Lys Ala Ile Glu Asp Tyr Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn 
    210                 215                 220                 


Arg Ser Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala Tyr Tyr Lys Gln 
225                 230                 235                 240 


Gly Asp Tyr Gln Lys Ala Ile Glu Tyr Tyr Gln Lys Ala Leu Glu Leu 
                245                 250                 255     


Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala Tyr Tyr 
            260                 265                 270         


Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu Tyr Tyr Gln Lys Ala Leu 
        275                 280                 285             


Glu Leu Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala 
    290                 295                 300                 


Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu Asp Tyr Gln Lys 
305                 310                 315                 320 


Ala Leu Glu Leu Asp Pro Asn Asn Leu Gln Arg Ser Ala Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Ser 
            340                 345                 


<210>  54
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  54

Lys Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala Tyr Tyr Lys Gln 
            20                  25                  30          


Gly Asp Tyr Gln Lys Ala Ile Glu Tyr Tyr Gln Lys Ala Leu Glu Leu 
        35                  40                  45              


Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala Tyr Tyr 
    50                  55                  60                  


Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu Tyr Tyr Gln Lys Ala Leu 
65                  70                  75                  80  


Glu Leu Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala 
                85                  90                  95      


Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu Asp Tyr Gln Lys 
            100                 105                 110         


Ala Leu Glu Leu Asp Pro Asn Asn Leu Gln Ala Glu Ala Trp Lys Asn 
        115                 120                 125             


Leu Gly Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu 
    130                 135                 140                 


Tyr Tyr Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn Ala Ser Ala Trp 
145                 150                 155                 160 


Tyr Asn Leu Gly Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala 
                165                 170                 175     


Ile Glu Tyr Tyr Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn Ala Lys 
            180                 185                 190         


Ala Trp Tyr Arg Arg Gly Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln 
        195                 200                 205             


Lys Ala Ile Glu Asp Tyr Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn 
    210                 215                 220                 


Arg Ser Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala Tyr Tyr Lys Gln 
225                 230                 235                 240 


Gly Asp Tyr Gln Lys Ala Ile Glu Tyr Tyr Gln Lys Ala Leu Glu Leu 
                245                 250                 255     


Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala Tyr Tyr 
            260                 265                 270         


Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu Tyr Tyr Gln Lys Ala Leu 
        275                 280                 285             


Glu Leu Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala 
    290                 295                 300                 


Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu Asp Tyr Gln Lys 
305                 310                 315                 320 


Ala Leu Glu Leu Asp Pro Asn Asn Leu Gln Ala Glu Ala Trp Lys Asn 
                325                 330                 335     


Leu Gly Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu 
            340                 345                 350         


Tyr Tyr Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn Ala Ser Ala Trp 
        355                 360                 365             


Tyr Asn Leu Gly Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala 
    370                 375                 380                 


Ile Glu Tyr Tyr Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn Ala Lys 
385                 390                 395                 400 


Ala Trp Tyr Arg Arg Gly Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln 
                405                 410                 415     


Lys Ala Ile Glu Asp Tyr Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn 
            420                 425                 430         


Arg Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        435                 440                 445             


Gly Ala Ser 
    450     


<210>  55
<211>  733
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  55

Gly Ser Gly Gly Gly Ser Gly Asp Ala His Lys Ser Glu Val Ala His 
1               5                   10                  15      


Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile 
            20                  25                  30          


Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp His Val Lys 
        35                  40                  45              


Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu 
    50                  55                  60                  


Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys 
65                  70                  75                  80  


Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp 
                85                  90                  95      


Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His 
            100                 105                 110         


Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp 
        115                 120                 125             


Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys 
    130                 135                 140                 


Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu 
145                 150                 155                 160 


Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys 
                165                 170                 175     


Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu 
            180                 185                 190         


Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala 
        195                 200                 205             


Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala 
    210                 215                 220                 


Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys 
225                 230                 235                 240 


Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp 
                245                 250                 255     


Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys 
            260                 265                 270         


Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys 
        275                 280                 285             


Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu 
    290                 295                 300                 


Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys 
305                 310                 315                 320 


Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met 
                325                 330                 335     


Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu 
            340                 345                 350         


Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys 
        355                 360                 365             


Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe 
    370                 375                 380                 


Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu 
385                 390                 395                 400 


Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val 
                405                 410                 415     


Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu 
            420                 425                 430         


Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro 
        435                 440                 445             


Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu 
    450                 455                 460                 


Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val 
465                 470                 475                 480 


Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser 
                485                 490                 495     


Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Gln Ala Glu 
            500                 505                 510         


Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg 
        515                 520                 525             


Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro 
    530                 535                 540                 


Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala 
545                 550                 555                 560 


Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala 
                565                 570                 575     


Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585                 590         


Lys Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        595                 600                 605             


Gly Ser Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala Tyr Tyr Lys Gln 
    610                 615                 620                 


Gly Asp Tyr Gln Lys Ala Ile Glu Tyr Tyr Gln Lys Ala Leu Glu Leu 
625                 630                 635                 640 


Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala Tyr Tyr 
                645                 650                 655     


Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu Tyr Tyr Gln Lys Ala Leu 
            660                 665                 670         


Glu Leu Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala 
        675                 680                 685             


Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu Asp Tyr Gln Lys 
    690                 695                 700                 


Ala Leu Glu Leu Asp Pro Asn Asn Leu Gln Arg Ser Ala Gly Gly Gly 
705                 710                 715                 720 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Ser 
                725                 730             


<210>  56
<211>  837
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  56

Gly Ser Gly Gly Gly Ser Gly Asp Ala His Lys Ser Glu Val Ala His 
1               5                   10                  15      


Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile 
            20                  25                  30          


Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp His Val Lys 
        35                  40                  45              


Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu 
    50                  55                  60                  


Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys 
65                  70                  75                  80  


Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp 
                85                  90                  95      


Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His 
            100                 105                 110         


Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp 
        115                 120                 125             


Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys 
    130                 135                 140                 


Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu 
145                 150                 155                 160 


Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys 
                165                 170                 175     


Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu 
            180                 185                 190         


Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala 
        195                 200                 205             


Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala 
    210                 215                 220                 


Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys 
225                 230                 235                 240 


Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp 
                245                 250                 255     


Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys 
            260                 265                 270         


Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys 
        275                 280                 285             


Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu 
    290                 295                 300                 


Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys 
305                 310                 315                 320 


Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met 
                325                 330                 335     


Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu 
            340                 345                 350         


Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys 
        355                 360                 365             


Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe 
    370                 375                 380                 


Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu 
385                 390                 395                 400 


Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val 
                405                 410                 415     


Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu 
            420                 425                 430         


Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro 
        435                 440                 445             


Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu 
    450                 455                 460                 


Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val 
465                 470                 475                 480 


Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser 
                485                 490                 495     


Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Gln Ala Glu 
            500                 505                 510         


Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg 
        515                 520                 525             


Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro 
    530                 535                 540                 


Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala 
545                 550                 555                 560 


Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala 
                565                 570                 575     


Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585                 590         


Lys Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        595                 600                 605             


Gly Ser Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala Tyr Tyr Lys Gln 
    610                 615                 620                 


Gly Asp Tyr Gln Lys Ala Ile Glu Tyr Tyr Gln Lys Ala Leu Glu Leu 
625                 630                 635                 640 


Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala Tyr Tyr 
                645                 650                 655     


Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu Tyr Tyr Gln Lys Ala Leu 
            660                 665                 670         


Glu Leu Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala 
        675                 680                 685             


Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu Asp Tyr Gln Lys 
    690                 695                 700                 


Ala Leu Glu Leu Asp Pro Asn Asn Leu Gln Ala Glu Ala Trp Lys Asn 
705                 710                 715                 720 


Leu Gly Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu 
                725                 730                 735     


Tyr Tyr Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn Ala Ser Ala Trp 
            740                 745                 750         


Tyr Asn Leu Gly Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala 
        755                 760                 765             


Ile Glu Tyr Tyr Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn Ala Lys 
    770                 775                 780                 


Ala Trp Tyr Arg Arg Gly Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln 
785                 790                 795                 800 


Lys Ala Ile Glu Asp Tyr Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn 
                805                 810                 815     


Arg Ser Arg Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            820                 825                 830         


Gly Gly Gly Ala Ser 
        835         


<210>  57
<211>  1533
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  57

Gly Ser Gly Gly Gly Ser Gly Asp Ala His Lys Ser Glu Val Ala His 
1               5                   10                  15      


Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile 
            20                  25                  30          


Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp His Val Lys 
        35                  40                  45              


Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu 
    50                  55                  60                  


Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys 
65                  70                  75                  80  


Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp 
                85                  90                  95      


Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His 
            100                 105                 110         


Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp 
        115                 120                 125             


Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys 
    130                 135                 140                 


Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu 
145                 150                 155                 160 


Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys 
                165                 170                 175     


Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu 
            180                 185                 190         


Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala 
        195                 200                 205             


Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala 
    210                 215                 220                 


Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys 
225                 230                 235                 240 


Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp 
                245                 250                 255     


Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys 
            260                 265                 270         


Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys 
        275                 280                 285             


Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu 
    290                 295                 300                 


Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys 
305                 310                 315                 320 


Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met 
                325                 330                 335     


Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu 
            340                 345                 350         


Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys 
        355                 360                 365             


Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe 
    370                 375                 380                 


Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu 
385                 390                 395                 400 


Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val 
                405                 410                 415     


Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu 
            420                 425                 430         


Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro 
        435                 440                 445             


Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu 
    450                 455                 460                 


Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val 
465                 470                 475                 480 


Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser 
                485                 490                 495     


Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Gln Ala Glu 
            500                 505                 510         


Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg 
        515                 520                 525             


Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro 
    530                 535                 540                 


Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala 
545                 550                 555                 560 


Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala 
                565                 570                 575     


Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585                 590         


Gly Ser Gly Gly Gly Ser Gly Asp Ala His Lys Ser Glu Val Ala His 
        595                 600                 605             


Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile 
    610                 615                 620                 


Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp His Val Lys 
625                 630                 635                 640 


Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu 
                645                 650                 655     


Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys 
            660                 665                 670         


Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp 
        675                 680                 685             


Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His 
    690                 695                 700                 


Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp 
705                 710                 715                 720 


Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys 
                725                 730                 735     


Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu 
            740                 745                 750         


Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys 
        755                 760                 765             


Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu 
    770                 775                 780                 


Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala 
785                 790                 795                 800 


Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala 
                805                 810                 815     


Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys 
            820                 825                 830         


Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp 
        835                 840                 845             


Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys 
    850                 855                 860                 


Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys 
865                 870                 875                 880 


Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu 
                885                 890                 895     


Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys 
            900                 905                 910         


Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met 
        915                 920                 925             


Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu 
    930                 935                 940                 


Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys 
945                 950                 955                 960 


Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe 
                965                 970                 975     


Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu 
            980                 985                 990         


Leu Phe Glu Gln Leu Gly Glu Tyr  Lys Phe Gln Asn Ala  Leu Leu Val 
        995                 1000                 1005             


Arg Tyr  Thr Lys Lys Val Pro  Gln Val Ser Thr Pro  Thr Leu Val 
    1010                 1015                 1020             


Glu Val  Ser Arg Asn Leu Gly  Lys Val Gly Ser Lys  Cys Cys Lys 
    1025                 1030                 1035             


His Pro  Glu Ala Lys Arg Met  Pro Cys Ala Glu Asp  Tyr Leu Ser 
    1040                 1045                 1050             


Val Val  Leu Asn Gln Leu Cys  Val Leu His Glu Lys  Thr Pro Val 
    1055                 1060                 1065             


Ser Asp  Arg Val Thr Lys Cys  Cys Thr Glu Ser Leu  Val Asn Arg 
    1070                 1075                 1080             


Arg Pro  Cys Phe Ser Ala Leu  Glu Val Asp Glu Thr  Tyr Val Pro 
    1085                 1090                 1095             


Lys Glu  Phe Gln Ala Glu Thr  Phe Thr Phe His Ala  Asp Ile Cys 
    1100                 1105                 1110             


Thr Leu  Ser Glu Lys Glu Arg  Gln Ile Lys Lys Gln  Thr Ala Leu 
    1115                 1120                 1125             


Val Glu  Leu Val Lys His Lys  Pro Lys Ala Thr Lys  Glu Gln Leu 
    1130                 1135                 1140             


Lys Ala  Val Met Asp Asp Phe  Ala Ala Phe Val Glu  Lys Cys Cys 
    1145                 1150                 1155             


Lys Ala  Asp Asp Lys Glu Thr  Cys Phe Ala Glu Glu  Gly Lys Lys 
    1160                 1165                 1170             


Leu Val  Ala Ala Ser Gln Ala  Ala Leu Gly Leu Lys  Leu Ser Gly 
    1175                 1180                 1185             


Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Ala 
    1190                 1195                 1200             


Glu Ala  Trp Tyr Asn Leu Gly  Asn Ala Tyr Tyr Lys  Gln Gly Asp 
    1205                 1210                 1215             


Tyr Gln  Lys Ala Ile Glu Tyr  Tyr Gln Lys Ala Leu  Glu Leu Asp 
    1220                 1225                 1230             


Pro Asn  Asn Ala Glu Ala Trp  Tyr Asn Leu Gly Asn  Ala Tyr Tyr 
    1235                 1240                 1245             


Lys Gln  Gly Asp Tyr Gln Lys  Ala Ile Glu Tyr Tyr  Gln Lys Ala 
    1250                 1255                 1260             


Leu Glu  Leu Asp Pro Asn Asn  Ala Glu Ala Trp Tyr  Asn Leu Gly 
    1265                 1270                 1275             


Asn Ala  Tyr Tyr Lys Gln Gly  Asp Tyr Gln Lys Ala  Ile Glu Asp 
    1280                 1285                 1290             


Tyr Gln  Lys Ala Leu Glu Leu  Asp Pro Asn Asn Leu  Gln Ala Glu 
    1295                 1300                 1305             


Ala Trp  Lys Asn Leu Gly Asn  Ala Tyr Tyr Lys Gln  Gly Asp Tyr 
    1310                 1315                 1320             


Gln Lys  Ala Ile Glu Tyr Tyr  Gln Lys Ala Leu Glu  Leu Asp Pro 
    1325                 1330                 1335             


Asn Asn  Ala Ser Ala Trp Tyr  Asn Leu Gly Asn Ala  Tyr Tyr Lys 
    1340                 1345                 1350             


Gln Gly  Asp Tyr Gln Lys Ala  Ile Glu Tyr Tyr Gln  Lys Ala Leu 
    1355                 1360                 1365             


Glu Leu  Asp Pro Asn Asn Ala  Lys Ala Trp Tyr Arg  Arg Gly Asn 
    1370                 1375                 1380             


Ala Tyr  Tyr Lys Gln Gly Asp  Tyr Gln Lys Ala Ile  Glu Asp Tyr 
    1385                 1390                 1395             


Gln Lys  Ala Leu Glu Leu Asp  Pro Asn Asn Arg Ser  Ala Glu Ala 
    1400                 1405                 1410             


Trp Tyr  Asn Leu Gly Asn Ala  Tyr Tyr Lys Gln Gly  Asp Tyr Gln 
    1415                 1420                 1425             


Lys Ala  Ile Glu Tyr Tyr Gln  Lys Ala Leu Glu Leu  Asp Pro Asn 
    1430                 1435                 1440             


Asn Ala  Glu Ala Trp Tyr Asn  Leu Gly Asn Ala Tyr  Tyr Lys Gln 
    1445                 1450                 1455             


Gly Asp  Tyr Gln Lys Ala Ile  Glu Tyr Tyr Gln Lys  Ala Leu Glu 
    1460                 1465                 1470             


Leu Asp  Pro Asn Asn Ala Glu  Ala Trp Tyr Asn Leu  Gly Asn Ala 
    1475                 1480                 1485             


Tyr Tyr  Lys Gln Gly Asp Tyr  Gln Lys Ala Ile Glu  Asp Tyr Gln 
    1490                 1495                 1500             


Lys Ala  Leu Glu Leu Asp Pro  Asn Asn Leu Gln Arg  Ser Ala Gly 
    1505                 1510                 1515             


Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ala Ser 
    1520                 1525                 1530             


<210>  58
<211>  1043
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  58

Gly Ser Gly Gly Gly Ser Gly Asp Ala His Lys Ser Glu Val Ala His 
1               5                   10                  15      


Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile 
            20                  25                  30          


Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp His Val Lys 
        35                  40                  45              


Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu 
    50                  55                  60                  


Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys 
65                  70                  75                  80  


Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp 
                85                  90                  95      


Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His 
            100                 105                 110         


Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp 
        115                 120                 125             


Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys 
    130                 135                 140                 


Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu 
145                 150                 155                 160 


Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys 
                165                 170                 175     


Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu 
            180                 185                 190         


Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala 
        195                 200                 205             


Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala 
    210                 215                 220                 


Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys 
225                 230                 235                 240 


Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp 
                245                 250                 255     


Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys 
            260                 265                 270         


Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys 
        275                 280                 285             


Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu 
    290                 295                 300                 


Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys 
305                 310                 315                 320 


Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met 
                325                 330                 335     


Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu 
            340                 345                 350         


Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys 
        355                 360                 365             


Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe 
    370                 375                 380                 


Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu 
385                 390                 395                 400 


Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val 
                405                 410                 415     


Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu 
            420                 425                 430         


Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro 
        435                 440                 445             


Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu 
    450                 455                 460                 


Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val 
465                 470                 475                 480 


Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser 
                485                 490                 495     


Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Gln Ala Glu 
            500                 505                 510         


Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg 
        515                 520                 525             


Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro 
    530                 535                 540                 


Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala 
545                 550                 555                 560 


Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala 
                565                 570                 575     


Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585                 590         


Lys Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        595                 600                 605             


Gly Ser Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala Tyr Tyr Lys Gln 
    610                 615                 620                 


Gly Asp Tyr Gln Lys Ala Ile Glu Tyr Tyr Gln Lys Ala Leu Glu Leu 
625                 630                 635                 640 


Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala Tyr Tyr 
                645                 650                 655     


Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu Tyr Tyr Gln Lys Ala Leu 
            660                 665                 670         


Glu Leu Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala 
        675                 680                 685             


Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu Asp Tyr Gln Lys 
    690                 695                 700                 


Ala Leu Glu Leu Asp Pro Asn Asn Leu Gln Ala Glu Ala Trp Lys Asn 
705                 710                 715                 720 


Leu Gly Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu 
                725                 730                 735     


Tyr Tyr Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn Ala Ser Ala Trp 
            740                 745                 750         


Tyr Asn Leu Gly Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala 
        755                 760                 765             


Ile Glu Tyr Tyr Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn Ala Lys 
    770                 775                 780                 


Ala Trp Tyr Arg Arg Gly Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln 
785                 790                 795                 800 


Lys Ala Ile Glu Asp Tyr Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn 
                805                 810                 815     


Arg Ser Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala Tyr Tyr Lys Gln 
            820                 825                 830         


Gly Asp Tyr Gln Lys Ala Ile Glu Tyr Tyr Gln Lys Ala Leu Glu Leu 
        835                 840                 845             


Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala Tyr Tyr 
    850                 855                 860                 


Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu Tyr Tyr Gln Lys Ala Leu 
865                 870                 875                 880 


Glu Leu Asp Pro Asn Asn Ala Glu Ala Trp Tyr Asn Leu Gly Asn Ala 
                885                 890                 895     


Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu Asp Tyr Gln Lys 
            900                 905                 910         


Ala Leu Glu Leu Asp Pro Asn Asn Leu Gln Ala Glu Ala Trp Lys Asn 
        915                 920                 925             


Leu Gly Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala Ile Glu 
    930                 935                 940                 


Tyr Tyr Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn Ala Ser Ala Trp 
945                 950                 955                 960 


Tyr Asn Leu Gly Asn Ala Tyr Tyr Lys Gln Gly Asp Tyr Gln Lys Ala 
                965                 970                 975     


Ile Glu Tyr Tyr Gln Lys Ala Leu Glu Leu Asp Pro Asn Asn Ala Lys 
            980                 985                 990         


Ala Trp Tyr Arg Arg Gly Asn Ala  Tyr Tyr Lys Gln Gly  Asp Tyr Gln 
        995                 1000                 1005             


Lys Ala  Ile Glu Asp Tyr Gln  Lys Ala Leu Glu Leu  Asp Pro Asn 
    1010                 1015                 1020             


Asn Arg  Ser Ala Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1025                 1030                 1035             


Gly Gly  Gly Ala Ser 
    1040             


<210>  59
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  59

Gly Gly Gly Ser 
1               


<210>  60
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  60

Gly Gly Gly Gly Ser 
1               5   


<210>  61
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  61

Gly Gly Ser Gly 
1               


<210>  62
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  62

Gly Pro Lys Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala 
65                  70  


<210>  63
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  63

Gly Pro Lys Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Leu Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala 
65                  70  


<210>  64
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  64

Gly Pro Lys Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Ala Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala 
65                  70  


<210>  65
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  65

Gly Pro Lys Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Leu Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala 
65                  70  


<210>  66
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  66

Gly Pro Lys Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Leu Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Leu Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala 
65                  70  


<210>  67
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  67

Gly Pro Lys Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Leu Phe Asn Lys Pro Thr Gly Ala Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Leu Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala 
65                  70  


