                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Craik, Charles S.
       Bardine, Conner
       Evans, Michael
 
<120>  GRANZYME-ACTIVATABLE MEMBRANE-INTERACTING PEPTIDES AND METHODS OF
        USE

<130>  UCSF-644WO

<150>  US 63/216,890
<151>  2021-06-30

<160>  89    

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  1

Phe Val Gln Trp Phe Ser Lys Phe Leu Gly Arg Ile Leu 
1               5                   10              


<210>  2
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  2

Phe Val Gln Trp Phe Ser Lys Phe Leu Gly Lys Leu Leu 
1               5                   10              


<210>  3
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  3

Phe Val Gln Trp Phe Ser Lys Phe Leu Gly Lys 
1               5                   10      


<210>  4
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  4

Phe Phe Gln Trp Phe Ser Lys Phe Leu Gly Lys 
1               5                   10      


<210>  5
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  5

Ile Leu Gly Thr Ile Leu Gly Leu Leu Lys Gly Leu 
1               5                   10          


<210>  6
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  The amino acid at position 5 is Arg or Gln

<400>  6

Ser Phe Leu Leu Xaa Asn Pro Asn Asp Lys Tyr Glu Pro Phe Trp 
1               5                   10                  15  


<210>  7
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  7

Gln Asp Pro Asn Asp Gln Tyr Glu Pro Phe 
1               5                   10  


<210>  8
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  The amino acid at position 4 is Ile or Leu

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  The amino acid at position 10 is Ser or Gly

<400>  8

Phe Leu Pro Xaa Ile Ala Ser Leu Leu Xaa Lys Leu Leu 
1               5                   10              


<210>  9
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  9

Phe Leu Pro Leu Ile Gly Arg Val Leu Ser Gly Ile Leu 
1               5                   10              


<210>  10
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  10

Leu Leu Pro Ile Val Gly Asn Leu Leu Lys Ser Leu Leu 
1               5                   10              


<210>  11
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  11

Leu Leu Pro Ile Leu Gly Asn Leu Leu Asn Gly Leu Leu 
1               5                   10              


<210>  12
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  12

Leu Leu Pro Ile Val Gly Asn Leu Leu Asn Ser Leu Leu 
1               5                   10              


<210>  13
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  13

Val Leu Pro Ile Ile Gly Asn Leu Leu Asn Ser Leu Leu 
1               5                   10              


<210>  14
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  14

Phe Leu Pro Leu Ile Gly Lys Val Leu Ser Gly Ile Leu 
1               5                   10              


<210>  15
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  15

Phe Phe Pro Val Ile Gly Arg Ile Leu Asn Gly Ile Leu 
1               5                   10              


<210>  16
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  16

Leu Ser Pro Asn Leu Leu Lys Ser Leu Leu 
1               5                   10  


<210>  17
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  17

Leu Leu Pro Asn Leu Leu Lys Ser Leu Leu 
1               5                   10  


<210>  18
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  18

Phe Leu Pro Phe Leu Ala Lys Ile Leu Thr Gly Val Leu 
1               5                   10              


<210>  19
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  19

Phe Leu Pro Leu Phe Ala Ser Leu Ile Gly Lys Leu Leu 
1               5                   10              


<210>  20
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  20

Phe Leu Pro Phe Leu Ala Ser Leu Leu Thr Lys Val Leu 
1               5                   10              


<210>  21
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  21

Phe Leu Pro Phe Leu Ala Ser Leu Leu Ser Lys Val Leu 
1               5                   10              


<210>  22
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  22

Phe Leu Pro Phe Leu Ala Thr Leu Leu Ser Lys Val Leu 
1               5                   10              


<210>  23
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  23

Ser Ile Leu Pro Thr Ile Val Ser Phe Leu Ser Lys Val Phe 
1               5                   10                  


<210>  24
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  24

Ser Ile Leu Pro Thr Ile Val Ser Phe Leu Ser Lys Phe Leu 
1               5                   10                  


<210>  25
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  25

Ser Ile Leu Pro Thr Ile Val Ser Phe Leu Thr Lys Phe Leu 
1               5                   10                  


<210>  26
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  26

Phe Ile Leu Pro Leu Ile Ala Ser Phe Leu Ser Lys Phe Leu 
1               5                   10                  


<210>  27
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  27

Val Leu Pro Leu Ile Ser Met Ala Leu Gly Lys Leu Leu 
1               5                   10              


<210>  28
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  28

Asn Phe Leu Gly Thr Leu Ile Asn Leu Ala Lys Lys Ile Met 
1               5                   10                  


<210>  29
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  29

Phe Leu Pro Ile Leu Ile Asn Leu Ile His Lys Gly Leu Leu 
1               5                   10                  


<210>  30
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  30

Phe Leu Pro Ile Val Gly Lys Leu Leu Ser Gly Leu Leu 
1               5                   10              


<210>  31
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  31

Phe Leu Pro Ile Ala Ser Leu Leu Gly Lys Tyr Leu 
1               5                   10          


<210>  32
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  32

Phe Ile Ser Ala Ile Ala Ser Met Leu Gly Lys Phe Leu 
1               5                   10              


<210>  33
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  33

Phe Leu Ser Ala Ile Ala Ser Met Leu Gly Lys Phe Leu 
1               5                   10              


<210>  34
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  34

Phe Ile Ser Ala Ile Ala Ser Phe Leu Gly Lys Phe Leu 
1               5                   10              


<210>  35
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  35

Phe Leu Phe Pro Leu Ile Thr Ser Phe Leu Ser Lys Val Leu 
1               5                   10                  


<210>  36
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  36

Phe Leu Pro Ala Ile Ala Gly Ile Leu Ser Gln Leu Phe 
1               5                   10              


<210>  37
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  37

Phe Leu Pro Leu Ile Ala Gly Leu Leu Gly Lys Leu Phe 
1               5                   10              


<210>  38
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  38

Phe Phe Pro Ile Gly Val Phe Cys Lys Ile Phe Lys Thr Cys 
1               5                   10                  


<210>  39
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  39

Phe Phe Pro Leu Ala Leu Leu Cys Lys Val Phe Lys Lys Cys 
1               5                   10                  


<210>  40
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  40

Phe Leu Leu Phe Pro Leu Met Cys Lys Ile Gln Gly Lys Cys 
1               5                   10                  


<210>  41
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  41

Phe Val Leu Pro Leu Val Met Cys Lys Ile Leu Arg Lys Cys 
1               5                   10                  


<210>  42
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  42

Phe Gly Leu Pro Met Leu Ser Ile Leu Pro Lys Ala Leu Cys Ile Leu 
1               5                   10                  15      


Leu Lys Arg Lys Cys 
            20      


<210>  43
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  43

Arg Arg Trp Trp Arg Phe 
1               5       


<210>  44
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  44

Phe Arg Trp Trp His Arg 
1               5       


<210>  45
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  45

Pro Phe Lys Leu Ser Leu His Leu 
1               5               


<210>  46
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  46

Thr Pro Phe Lys Leu Ser Leu His Leu 
1               5                   


<210>  47
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  47

Phe Phe Phe Leu Ser Arg Ile Phe 
1               5               


<210>  48
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  48

Phe Phe Trp Leu Ser Lys Ile Phe 
1               5               


<210>  49
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  49

Lys Val Phe Leu Gly Leu Lys 
1               5           


<210>  50
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  50

Gly Ile His Asp Ile Leu Lys Tyr Gly Lys Pro Ser 
1               5                   10          


<210>  51
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  51

Ile Leu Gly Lys Ile Trp Glu Gly Ile Lys Ser Leu Phe 
1               5                   10              


<210>  52
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  52

Leu Lys Leu Lys Ser Ile Val Ser Trp Ala Lys Lys Val Leu 
1               5                   10                  


<210>  53
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  53

Lys Lys Lys Lys Pro Leu Phe Gly Leu Phe Phe Gly Leu Phe 
1               5                   10                  


<210>  54
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  54

Ile Asn Trp Leu Lys Leu Gly Lys Ala Ile Ile Asp Ala Leu 
1               5                   10                  


<210>  55
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  55

Ser Phe Leu Leu Arg Asn Pro Asn Asp Lys Tyr Glu Pro Phe Trp 
1               5                   10                  15  


<210>  56
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  56

Ser Phe Leu Leu Gln Asp Pro Asn Asp Gln Tyr Glu Pro Phe Trp 
1               5                   10                  15  


<210>  57
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  57

Ile Glu Pro Asp Val Ser Gln Val 
1               5               


<210>  58
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  58

Trp Ala Phe Arg Ser Arg Tyr His 
1               5               


<210>  59
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  59

Ala Ser Pro Arg Ala Gly Gly Lys 
1               5               


<210>  60
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  60

Lys Glu Pro Leu Ser Ala Glu Ala 
1               5               


<210>  61
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  SITE
<222>  (4)..(4)
<223>  The amino acid at position 4 is D-aspartic acid

<400>  61

Ile Glu Pro Asp Val Ser Gln Val 
1               5               


<210>  62
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  SITE
<222>  (1)..(2)
<223>  The amino acids at positions 1 and 2 comprise 
       7-methoxycoumarin-4-acetic acid (MCA)

<220>
<221>  SITE
<222>  (10)..(10)
<223>  The amino acid at position 10 comprises a DNP quencher

<400>  62

Lys Ile Glu Pro Asp Val Ser Gln Val Lys 
1               5                   10  


<210>  63
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  SITE
<222>  (1)..(1)
<223>  The amino acid at position 1 comprises dota-hexanoic acid

<400>  63

Phe Val Gln Trp Phe Ser Lys Phe Leu Gly Lys Ile Glu Pro Asp Val 
1               5                   10                  15      


Ser Gln Val Gln Asp Pro Asn Asp Gln Tyr Glu Pro Phe 
            20                  25                  


<210>  64
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  64

Ile Glu Pro Asp Val Ser Val Gln 
1               5               


<210>  65
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  65

Leu Thr Tyr Asp Phe Trp Ile Gln 
1               5               


<210>  66
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  66

Pro Gln Val Asp Leu Tyr Asp Lys 
1               5               


<210>  67
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  67

Val Val Gln Asp Lys His Glu Ile 
1               5               


<210>  68
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  68

Val Tyr Ala Asp Ser Ser Glu Trp 
1               5               


<210>  69
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  69

Thr Met Ala Asp Ser Gln Glu Ser 
1               5               


<210>  70
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  VARIANT
<222>  (7)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  70

Gly His Ile Asp His Met Xaa Xaa 
1               5               


<210>  71
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  71

Leu Glu Gln Asp Val Trp Ile Ala 
1               5               


<210>  72
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  72

Leu Asp Pro Asp Asn Phe Lys Arg 
1               5               


<210>  73
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  VARIANT
<222>  (1)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  73

Xaa Xaa Pro Asp Phe Tyr Leu Gly 
1               5               


<210>  74
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  74

Met Gly Pro Asp Ala Phe Asn Leu 
1               5               


<210>  75
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  VARIANT
<222>  (7)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  75

Leu Lys Asp Asp Met Gly Xaa Xaa 
1               5               


<210>  76
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  76

Ile Trp Phe Asp Tyr Thr Leu Lys 
1               5               


<210>  77
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  77

Xaa Ile Gly Asp Asn Val Glu Trp 
1               5               


<210>  78
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  VARIANT
<222>  (1)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  78

Xaa Xaa Xaa Asp Gln Val Asn Leu 
1               5               


<210>  79
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  VARIANT
<222>  (7)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  79

Pro Gln Ala Asp Gln Trp Xaa Xaa 
1               5               


<210>  80
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  VARIANT
<222>  (6)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  80

Pro Ser Val Asp Met Xaa Xaa Xaa 
1               5               


<210>  81
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  81

Xaa Asn Val Asp Trp Thr Ala Pro 
1               5               


<210>  82
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  82

Tyr Gly Tyr Asp Leu Gln Thr Ala 
1               5               


<210>  83
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  83

His Gly Phe Asp Glu Ala His Asn 
1               5               


<210>  84
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  84

His Ser His Asp Ser Trp Lys Ala 
1               5               


<210>  85
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  85

Lys Gln Asp Asp Leu Met Ser Glu 
1               5               


<210>  86
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  86

Ser Phe Gly Asp Ile Met Glu Met 
1               5               


<210>  87
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  VARIANT
<222>  (7)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  87

Val Asn Asp Asp Val Lys Xaa Xaa 
1               5               


<210>  88
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  VARIANT
<222>  (1)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  88

Xaa Xaa Xaa Asp Lys Gln Phe Thr 
1               5               


<210>  89
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  VARIANT
<222>  (7)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  89

Asn Asp Val Asp Gly Gly Xaa Xaa 
1               5               


