                         SEQUENCE LISTING

<110>  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
 
<120>  ALTERING CYTOKINE SPECIFICITY THROUGH BINDING VALENCY

<130>  P-593176-PC

<150>  US 63/216,718
<151>  2021-06-30

<160>  76    

<170>  PatentIn version 3.5

<210>  1
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  2
<211>  612
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Single chain tetravalent IL-2

<400>  2

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr 
                165                 170                 175     


Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu 
            180                 185                 190         


Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys 
        195                 200                 205             


Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr 
    210                 215                 220                 


Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu 
225                 230                 235                 240 


Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg 
                245                 250                 255     


Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser 
            260                 265                 270         


Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val 
        275                 280                 285             


Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr 
    290                 295                 300                 


Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr 
                325                 330                 335     


Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn 
            340                 345                 350         


Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe 
        355                 360                 365             


Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys 
    370                 375                 380                 


Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln 
385                 390                 395                 400 


Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn 
                405                 410                 415     


Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu 
            420                 425                 430         


Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile 
        435                 440                 445             


Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
465                 470                 475                 480 


Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu 
                485                 490                 495     


Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn 
            500                 505                 510         


Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys 
        515                 520                 525             


Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro 
    530                 535                 540                 


Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg 
545                 550                 555                 560 


Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys 
                565                 570                 575     


Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr 
            580                 585                 590         


Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile 
        595                 600                 605             


Ser Thr Leu Thr 
    610         


<210>  3
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AviTag sequence

<400>  3

Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  


<210>  4
<211>  459
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain trivalent IL-2

<400>  4

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr 
                165                 170                 175     


Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu 
            180                 185                 190         


Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys 
        195                 200                 205             


Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr 
    210                 215                 220                 


Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu 
225                 230                 235                 240 


Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg 
                245                 250                 255     


Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser 
            260                 265                 270         


Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val 
        275                 280                 285             


Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr 
    290                 295                 300                 


Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr 
                325                 330                 335     


Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn 
            340                 345                 350         


Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe 
        355                 360                 365             


Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys 
    370                 375                 380                 


Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln 
385                 390                 395                 400 


Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn 
                405                 410                 415     


Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu 
            420                 425                 430         


Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile 
        435                 440                 445             


Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr 
    450                 455                 


<210>  5
<211>  765
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain pentavalent IL-2

<400>  5

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr 
                165                 170                 175     


Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu 
            180                 185                 190         


Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys 
        195                 200                 205             


Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr 
    210                 215                 220                 


Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu 
225                 230                 235                 240 


Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg 
                245                 250                 255     


Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser 
            260                 265                 270         


Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val 
        275                 280                 285             


Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr 
    290                 295                 300                 


Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr 
                325                 330                 335     


Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn 
            340                 345                 350         


Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe 
        355                 360                 365             


Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys 
    370                 375                 380                 


Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln 
385                 390                 395                 400 


Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn 
                405                 410                 415     


Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu 
            420                 425                 430         


Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile 
        435                 440                 445             


Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
465                 470                 475                 480 


Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu 
                485                 490                 495     


Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn 
            500                 505                 510         


Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys 
        515                 520                 525             


Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro 
    530                 535                 540                 


Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg 
545                 550                 555                 560 


Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys 
                565                 570                 575     


Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr 
            580                 585                 590         


Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile 
        595                 600                 605             


Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys 
625                 630                 635                 640 


Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile 
                645                 650                 655     


Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu 
            660                 665                 670         


Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu 
        675                 680                 685             


Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu 
    690                 695                 700                 


Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn 
705                 710                 715                 720 


Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met 
                725                 730                 735     


Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg 
            740                 745                 750         


Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr 
        755                 760                 765 


<210>  6
<211>  918
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain hexavalent IL-2

<400>  6

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr 
                165                 170                 175     


Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu 
            180                 185                 190         


Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys 
        195                 200                 205             


Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr 
    210                 215                 220                 


Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu 
225                 230                 235                 240 


Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg 
                245                 250                 255     


Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser 
            260                 265                 270         


Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val 
        275                 280                 285             


Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr 
    290                 295                 300                 


Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr 
                325                 330                 335     


Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn 
            340                 345                 350         


Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe 
        355                 360                 365             


Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys 
    370                 375                 380                 


Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln 
385                 390                 395                 400 


Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn 
                405                 410                 415     


Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu 
            420                 425                 430         


Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile 
        435                 440                 445             


Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
465                 470                 475                 480 


Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu 
                485                 490                 495     


Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn 
            500                 505                 510         


Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys 
        515                 520                 525             


Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro 
    530                 535                 540                 


Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg 
545                 550                 555                 560 


Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys 
                565                 570                 575     


Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr 
            580                 585                 590         


Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile 
        595                 600                 605             


Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys 
625                 630                 635                 640 


Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile 
                645                 650                 655     


Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu 
            660                 665                 670         


Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu 
        675                 680                 685             


Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu 
    690                 695                 700                 


Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn 
705                 710                 715                 720 


Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met 
                725                 730                 735     


Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg 
            740                 745                 750         


Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly 
        755                 760                 765             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    770                 775                 780                 


Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
785                 790                 795                 800 


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
                805                 810                 815     


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
            820                 825                 830         


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
        835                 840                 845             


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His 
    850                 855                 860                 


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
865                 870                 875                 880 


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
                885                 890                 895     


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser 
            900                 905                 910         


Ile Ile Ser Thr Leu Thr 
        915             


<210>  7
<211>  1071
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain heptavalent IL-2

<400>  7

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr 
                165                 170                 175     


Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu 
            180                 185                 190         


Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys 
        195                 200                 205             


Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr 
    210                 215                 220                 


Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu 
225                 230                 235                 240 


Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg 
                245                 250                 255     


Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser 
            260                 265                 270         


Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val 
        275                 280                 285             


Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr 
    290                 295                 300                 


Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr 
                325                 330                 335     


Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn 
            340                 345                 350         


Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe 
        355                 360                 365             


Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys 
    370                 375                 380                 


Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln 
385                 390                 395                 400 


Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn 
                405                 410                 415     


Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu 
            420                 425                 430         


Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile 
        435                 440                 445             


Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
465                 470                 475                 480 


Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu 
                485                 490                 495     


Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn 
            500                 505                 510         


Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys 
        515                 520                 525             


Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro 
    530                 535                 540                 


Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg 
545                 550                 555                 560 


Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys 
                565                 570                 575     


Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr 
            580                 585                 590         


Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile 
        595                 600                 605             


Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys 
625                 630                 635                 640 


Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile 
                645                 650                 655     


Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu 
            660                 665                 670         


Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu 
        675                 680                 685             


Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu 
    690                 695                 700                 


Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn 
705                 710                 715                 720 


Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met 
                725                 730                 735     


Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg 
            740                 745                 750         


Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly 
        755                 760                 765             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    770                 775                 780                 


Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
785                 790                 795                 800 


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
                805                 810                 815     


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
            820                 825                 830         


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
        835                 840                 845             


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His 
    850                 855                 860                 


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
865                 870                 875                 880 


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
                885                 890                 895     


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser 
            900                 905                 910         


Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        915                 920                 925             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser 
    930                 935                 940                 


Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln 
945                 950                 955                 960 


Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg 
                965                 970                 975     


Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys 
            980                 985                 990         


His Leu Gln Cys Leu Glu Glu Glu  Leu Lys Pro Leu Glu  Glu Val Leu 
        995                 1000                 1005             


Asn Leu  Ala Gln Ser Lys Asn  Phe His Leu Arg Pro  Arg Asp Leu 
    1010                 1015                 1020             


Ile Ser  Asn Ile Asn Val Ile  Val Leu Glu Leu Lys  Gly Ser Glu 
    1025                 1030                 1035             


Thr Thr  Phe Met Cys Glu Tyr  Ala Asp Glu Thr Ala  Thr Ile Val 
    1040                 1045                 1050             


Glu Phe  Leu Asn Arg Trp Ile  Thr Phe Cys Gln Ser  Ile Ile Ser 
    1055                 1060                 1065             


Thr Leu  Thr 
    1070     


<210>  8
<211>  1224
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain octavalent IL-2

<400>  8

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr 
                165                 170                 175     


Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu 
            180                 185                 190         


Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys 
        195                 200                 205             


Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr 
    210                 215                 220                 


Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu 
225                 230                 235                 240 


Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg 
                245                 250                 255     


Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser 
            260                 265                 270         


Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val 
        275                 280                 285             


Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr 
    290                 295                 300                 


Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr 
                325                 330                 335     


Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn 
            340                 345                 350         


Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe 
        355                 360                 365             


Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys 
    370                 375                 380                 


Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln 
385                 390                 395                 400 


Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn 
                405                 410                 415     


Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu 
            420                 425                 430         


Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile 
        435                 440                 445             


Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
465                 470                 475                 480 


Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu 
                485                 490                 495     


Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn 
            500                 505                 510         


Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys 
        515                 520                 525             


Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro 
    530                 535                 540                 


Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg 
545                 550                 555                 560 


Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys 
                565                 570                 575     


Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr 
            580                 585                 590         


Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile 
        595                 600                 605             


Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys 
625                 630                 635                 640 


Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile 
                645                 650                 655     


Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu 
            660                 665                 670         


Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu 
        675                 680                 685             


Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu 
    690                 695                 700                 


Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn 
705                 710                 715                 720 


Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met 
                725                 730                 735     


Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg 
            740                 745                 750         


Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly 
        755                 760                 765             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    770                 775                 780                 


Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
785                 790                 795                 800 


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
                805                 810                 815     


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
            820                 825                 830         


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
        835                 840                 845             


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His 
    850                 855                 860                 


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
865                 870                 875                 880 


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
                885                 890                 895     


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser 
            900                 905                 910         


Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        915                 920                 925             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser 
    930                 935                 940                 


Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln 
945                 950                 955                 960 


Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg 
                965                 970                 975     


Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys 
            980                 985                 990         


His Leu Gln Cys Leu Glu Glu Glu  Leu Lys Pro Leu Glu  Glu Val Leu 
        995                 1000                 1005             


Asn Leu  Ala Gln Ser Lys Asn  Phe His Leu Arg Pro  Arg Asp Leu 
    1010                 1015                 1020             


Ile Ser  Asn Ile Asn Val Ile  Val Leu Glu Leu Lys  Gly Ser Glu 
    1025                 1030                 1035             


Thr Thr  Phe Met Cys Glu Tyr  Ala Asp Glu Thr Ala  Thr Ile Val 
    1040                 1045                 1050             


Glu Phe  Leu Asn Arg Trp Ile  Thr Phe Cys Gln Ser  Ile Ile Ser 
    1055                 1060                 1065             


Thr Leu  Thr Gly Gly Gly Gly  Ser Gly Gly Gly Gly  Ser Gly Gly 
    1070                 1075                 1080             


Gly Gly  Ser Gly Gly Gly Gly  Ser Ala Pro Thr Ser  Ser Ser Thr 
    1085                 1090                 1095             


Lys Lys  Thr Gln Leu Gln Leu  Glu His Leu Leu Leu  Asp Leu Gln 
    1100                 1105                 1110             


Met Ile  Leu Asn Gly Ile Asn  Asn Tyr Lys Asn Pro  Lys Leu Thr 
    1115                 1120                 1125             


Arg Met  Leu Thr Phe Lys Phe  Tyr Met Pro Lys Lys  Ala Thr Glu 
    1130                 1135                 1140             


Leu Lys  His Leu Gln Cys Leu  Glu Glu Glu Leu Lys  Pro Leu Glu 
    1145                 1150                 1155             


Glu Val  Leu Asn Leu Ala Gln  Ser Lys Asn Phe His  Leu Arg Pro 
    1160                 1165                 1170             


Arg Asp  Leu Ile Ser Asn Ile  Asn Val Ile Val Leu  Glu Leu Lys 
    1175                 1180                 1185             


Gly Ser  Glu Thr Thr Phe Met  Cys Glu Tyr Ala Asp  Glu Thr Ala 
    1190                 1195                 1200             


Thr Ile  Val Glu Phe Leu Asn  Arg Trp Ile Thr Phe  Cys Gln Ser 
    1205                 1210                 1215             


Ile Ile  Ser Thr Leu Thr 
    1220                 


<210>  9
<211>  552
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain, bivalent IL-2 with Fc hinge region (SEQ ID NO:16)

<400>  9

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr 
                165                 170                 175     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
            180                 185                 190         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        195                 200                 205             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    210                 215                 220                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
225                 230                 235                 240 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                245                 250                 255     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            260                 265                 270         


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        275                 280                 285             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    290                 295                 300                 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
305                 310                 315                 320 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                325                 330                 335     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            340                 345                 350         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        355                 360                 365             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    370                 375                 380                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
            420                 425                 430         


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
        435                 440                 445             


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr 
    450                 455                 460                 


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
465                 470                 475                 480 


Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn 
                485                 490                 495     


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val 
            500                 505                 510         


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
        515                 520                 525             


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys 
    530                 535                 540                 


Gln Ser Ile Ile Ser Thr Leu Thr 
545                 550         


<210>  10
<211>  858
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain, tetravalent IL-2 with Fc hinge region (SEQ ID 
       NO:16)

<400>  10

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr 
                165                 170                 175     


Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu 
            180                 185                 190         


Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys 
        195                 200                 205             


Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr 
    210                 215                 220                 


Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu 
225                 230                 235                 240 


Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg 
                245                 250                 255     


Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser 
            260                 265                 270         


Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val 
        275                 280                 285             


Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr 
    290                 295                 300                 


Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                325                 330                 335     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            340                 345                 350         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        355                 360                 365             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    370                 375                 380                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
385                 390                 395                 400 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                405                 410                 415     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            420                 425                 430         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        435                 440                 445             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    450                 455                 460                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
465                 470                 475                 480 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                485                 490                 495     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            500                 505                 510         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        515                 520                 525             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    530                 535                 540                 


Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 
545                 550                 555                 560 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser 
                565                 570                 575     


Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp 
            580                 585                 590         


Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu 
        595                 600                 605             


Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu 
    610                 615                 620                 


Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu 
625                 630                 635                 640 


Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp 
                645                 650                 655     


Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu 
            660                 665                 670         


Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu 
        675                 680                 685             


Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu 
    690                 695                 700                 


Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
705                 710                 715                 720 


Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln 
                725                 730                 735     


Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly 
            740                 745                 750         


Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys 
        755                 760                 765             


Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu 
    770                 775                 780                 


Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser 
785                 790                 795                 800 


Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val 
                805                 810                 815     


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr 
            820                 825                 830         


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
        835                 840                 845             


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr 
    850                 855             


<210>  11
<211>  595
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain, bivalent IL-7 with Fc

<400>  11

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            180                 185                 190         


Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        195                 200                 205             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    210                 215                 220                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
225                 230                 235                 240 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                245                 250                 255     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            260                 265                 270         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        275                 280                 285             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    290                 295                 300                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
305                 310                 315                 320 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                325                 330                 335     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            340                 345                 350         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        355                 360                 365             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    370                 375                 380                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
385                 390                 395                 400 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                405                 410                 415     


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            420                 425                 430         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Cys Asp Ile Glu 
        435                 440                 445             


Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp 
    450                 455                 460                 


Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn 
465                 470                 475                 480 


Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly 
                485                 490                 495     


Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met 
            500                 505                 510         


Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly 
        515                 520                 525             


Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro 
    530                 535                 540                 


Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys 
545                 550                 555                 560 


Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg 
                565                 570                 575     


Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr 
            580                 585                 590         


Lys Glu His 
        595 


<210>  12
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  12

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  13
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Linker sequence

<400>  13

Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser 
            20      


<210>  14
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His 
    


<210>  15
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  15

Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu 
1               5                   10                  15      


Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser 
            20                  25                  30          


Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp 
        35                  40                  45              


Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg 
    50                  55                  60                  


Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu 
65                  70                  75                  80  


Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val 
                85                  90                  95      


Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser 
            100                 105                 110         


Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu 
        115                 120                 125             


Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys 
    130                 135                 140                 


Ile Leu Met Gly Thr Lys Glu His 
145                 150         


<210>  16
<211>  225
<212>  PRT
<213>  Artificial

<220>
<223>  Fc hinge region CH2/CH3, without C-terminal K

<400>  16

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro 
225 


<210>  17
<211>  696
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain, tetravalent IL-7

<400>  17

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Gly Gly Gly Gly Ser Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys 
        195                 200                 205             


Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser 
    210                 215                 220                 


Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe 
225                 230                 235                 240 


Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg 
                245                 250                 255     


Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp 
            260                 265                 270         


Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu 
        275                 280                 285             


Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu 
    290                 295                 300                 


Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln 
305                 310                 315                 320 


Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile 
                325                 330                 335     


Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His Gly Gly 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Gly Gly Ser Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu 
    370                 375                 380                 


Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu 
385                 390                 395                 400 


Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His 
                405                 410                 415     


Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg 
            420                 425                 430         


Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu 
        435                 440                 445             


His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr 
    450                 455                 460                 


Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro 
465                 470                 475                 480 


Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu 
                485                 490                 495     


Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys 
            500                 505                 510         


Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His Gly Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    530                 535                 540                 


Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu 
545                 550                 555                 560 


Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser 
                565                 570                 575     


Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp 
            580                 585                 590         


Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg 
        595                 600                 605             


Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu 
    610                 615                 620                 


Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val 
625                 630                 635                 640 


Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser 
                645                 650                 655     


Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu 
            660                 665                 670         


Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys 
        675                 680                 685             


Ile Leu Met Gly Thr Lys Glu His 
    690                 695     


<210>  18
<211>  869
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain, pentavalent IL-7

<400>  18

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Gly Gly Gly Gly Ser Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys 
        195                 200                 205             


Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser 
    210                 215                 220                 


Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe 
225                 230                 235                 240 


Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg 
                245                 250                 255     


Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp 
            260                 265                 270         


Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu 
        275                 280                 285             


Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu 
    290                 295                 300                 


Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln 
305                 310                 315                 320 


Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile 
                325                 330                 335     


Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His Gly Gly 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Gly Gly Ser Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu 
    370                 375                 380                 


Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu 
385                 390                 395                 400 


Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His 
                405                 410                 415     


Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg 
            420                 425                 430         


Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu 
        435                 440                 445             


His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr 
    450                 455                 460                 


Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro 
465                 470                 475                 480 


Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu 
                485                 490                 495     


Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys 
            500                 505                 510         


Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His Gly Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    530                 535                 540                 


Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu 
545                 550                 555                 560 


Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser 
                565                 570                 575     


Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp 
            580                 585                 590         


Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg 
        595                 600                 605             


Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu 
    610                 615                 620                 


Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val 
625                 630                 635                 640 


Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser 
                645                 650                 655     


Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu 
            660                 665                 670         


Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys 
        675                 680                 685             


Ile Leu Met Gly Thr Lys Glu His Gly Gly Gly Gly Gly Ser Gly Gly 
    690                 695                 700                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Cys Asp 
705                 710                 715                 720 


Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser 
                725                 730                 735     


Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu 
            740                 745                 750         


Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys 
        755                 760                 765             


Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu 
    770                 775                 780                 


Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser 
785                 790                 795                 800 


Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg 
                805                 810                 815     


Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu 
            820                 825                 830         


Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu 
        835                 840                 845             


Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met 
    850                 855                 860                 


Gly Thr Lys Glu His 
865                 


<210>  19
<211>  1042
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain, hexavalent IL-7

<400>  19

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Gly Gly Gly Gly Ser Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys 
        195                 200                 205             


Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser 
    210                 215                 220                 


Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe 
225                 230                 235                 240 


Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg 
                245                 250                 255     


Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp 
            260                 265                 270         


Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu 
        275                 280                 285             


Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu 
    290                 295                 300                 


Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln 
305                 310                 315                 320 


Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile 
                325                 330                 335     


Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His Gly Gly 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Gly Gly Ser Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu 
    370                 375                 380                 


Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu 
385                 390                 395                 400 


Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His 
                405                 410                 415     


Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg 
            420                 425                 430         


Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu 
        435                 440                 445             


His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr 
    450                 455                 460                 


Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro 
465                 470                 475                 480 


Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu 
                485                 490                 495     


Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys 
            500                 505                 510         


Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His Gly Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    530                 535                 540                 


Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu 
545                 550                 555                 560 


Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser 
                565                 570                 575     


Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp 
            580                 585                 590         


Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg 
        595                 600                 605             


Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu 
    610                 615                 620                 


Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val 
625                 630                 635                 640 


Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser 
                645                 650                 655     


Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu 
            660                 665                 670         


Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys 
        675                 680                 685             


Ile Leu Met Gly Thr Lys Glu His Gly Gly Gly Gly Gly Ser Gly Gly 
    690                 695                 700                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Cys Asp 
705                 710                 715                 720 


Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser 
                725                 730                 735     


Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu 
            740                 745                 750         


Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys 
        755                 760                 765             


Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu 
    770                 775                 780                 


Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser 
785                 790                 795                 800 


Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg 
                805                 810                 815     


Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu 
            820                 825                 830         


Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu 
        835                 840                 845             


Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met 
    850                 855                 860                 


Gly Thr Lys Glu His Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
865                 870                 875                 880 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Cys Asp Ile Glu Gly 
                885                 890                 895     


Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln 
            900                 905                 910         


Leu Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu 
        915                 920                 925             


Phe Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met 
    930                 935                 940                 


Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn 
945                 950                 955                 960 


Ser Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr 
                965                 970                 975     


Thr Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala 
            980                 985                 990         


Ala Leu Gly Glu Ala Gln Pro Thr  Lys Ser Leu Glu Glu  Asn Lys Ser 
        995                 1000                 1005             


Leu Lys  Glu Gln Lys Lys Leu  Asn Asp Leu Cys Phe  Leu Lys Arg 
    1010                 1015                 1020             


Leu Leu  Gln Glu Ile Lys Thr  Cys Trp Asn Lys Ile  Leu Met Gly 
    1025                 1030                 1035             


Thr Lys  Glu His 
    1040         


<210>  20
<211>  1215
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain, heptavalent IL-7

<400>  20

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Gly Gly Gly Gly Ser Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys 
        195                 200                 205             


Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser 
    210                 215                 220                 


Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe 
225                 230                 235                 240 


Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg 
                245                 250                 255     


Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp 
            260                 265                 270         


Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu 
        275                 280                 285             


Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu 
    290                 295                 300                 


Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln 
305                 310                 315                 320 


Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile 
                325                 330                 335     


Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His Gly Gly 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Gly Gly Ser Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu 
    370                 375                 380                 


Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu 
385                 390                 395                 400 


Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His 
                405                 410                 415     


Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg 
            420                 425                 430         


Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu 
        435                 440                 445             


His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr 
    450                 455                 460                 


Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro 
465                 470                 475                 480 


Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu 
                485                 490                 495     


Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys 
            500                 505                 510         


Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His Gly Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    530                 535                 540                 


Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu 
545                 550                 555                 560 


Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser 
                565                 570                 575     


Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp 
            580                 585                 590         


Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg 
        595                 600                 605             


Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu 
    610                 615                 620                 


Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val 
625                 630                 635                 640 


Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser 
                645                 650                 655     


Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu 
            660                 665                 670         


Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys 
        675                 680                 685             


Ile Leu Met Gly Thr Lys Glu His Gly Gly Gly Gly Gly Ser Gly Gly 
    690                 695                 700                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Cys Asp 
705                 710                 715                 720 


Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser 
                725                 730                 735     


Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu 
            740                 745                 750         


Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys 
        755                 760                 765             


Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu 
    770                 775                 780                 


Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser 
785                 790                 795                 800 


Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg 
                805                 810                 815     


Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu 
            820                 825                 830         


Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu 
        835                 840                 845             


Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met 
    850                 855                 860                 


Gly Thr Lys Glu His Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
865                 870                 875                 880 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Cys Asp Ile Glu Gly 
                885                 890                 895     


Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln 
            900                 905                 910         


Leu Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu 
        915                 920                 925             


Phe Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met 
    930                 935                 940                 


Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn 
945                 950                 955                 960 


Ser Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr 
                965                 970                 975     


Thr Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala 
            980                 985                 990         


Ala Leu Gly Glu Ala Gln Pro Thr  Lys Ser Leu Glu Glu  Asn Lys Ser 
        995                 1000                 1005             


Leu Lys  Glu Gln Lys Lys Leu  Asn Asp Leu Cys Phe  Leu Lys Arg 
    1010                 1015                 1020             


Leu Leu  Gln Glu Ile Lys Thr  Cys Trp Asn Lys Ile  Leu Met Gly 
    1025                 1030                 1035             


Thr Lys  Glu His Gly Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1040                 1045                 1050             


Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser Asp Cys  Asp Ile Glu 
    1055                 1060                 1065             


Gly Lys  Asp Gly Lys Gln Tyr  Glu Ser Val Leu Met  Val Ser Ile 
    1070                 1075                 1080             


Asp Gln  Leu Leu Asp Ser Met  Lys Glu Ile Gly Ser  Asn Cys Leu 
    1085                 1090                 1095             


Asn Asn  Glu Phe Asn Phe Phe  Lys Arg His Ile Cys  Asp Ala Asn 
    1100                 1105                 1110             


Lys Glu  Gly Met Phe Leu Phe  Arg Ala Ala Arg Lys  Leu Arg Gln 
    1115                 1120                 1125             


Phe Leu  Lys Met Asn Ser Thr  Gly Asp Phe Asp Leu  His Leu Leu 
    1130                 1135                 1140             


Lys Val  Ser Glu Gly Thr Thr  Ile Leu Leu Asn Cys  Thr Gly Gln 
    1145                 1150                 1155             


Val Lys  Gly Arg Lys Pro Ala  Ala Leu Gly Glu Ala  Gln Pro Thr 
    1160                 1165                 1170             


Lys Ser  Leu Glu Glu Asn Lys  Ser Leu Lys Glu Gln  Lys Lys Leu 
    1175                 1180                 1185             


Asn Asp  Leu Cys Phe Leu Lys  Arg Leu Leu Gln Glu  Ile Lys Thr 
    1190                 1195                 1200             


Cys Trp  Asn Lys Ile Leu Met  Gly Thr Lys Glu His  
    1205                 1210                 1215 


<210>  21
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain, octavalent IL-7

<400>  21

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Gly Gly Gly Gly Ser Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys 
        195                 200                 205             


Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser 
    210                 215                 220                 


Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe 
225                 230                 235                 240 


Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg 
                245                 250                 255     


Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp 
            260                 265                 270         


Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu 
        275                 280                 285             


Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu 
    290                 295                 300                 


Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln 
305                 310                 315                 320 


Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile 
                325                 330                 335     


Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His Gly Gly 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Gly Gly Ser Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu 
    370                 375                 380                 


Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu 
385                 390                 395                 400 


Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His 
                405                 410                 415     


Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg 
            420                 425                 430         


Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu 
        435                 440                 445             


His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr 
    450                 455                 460                 


Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro 
465                 470                 475                 480 


Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu 
                485                 490                 495     


Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys 
            500                 505                 510         


Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His Gly Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    530                 535                 540                 


Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu 
545                 550                 555                 560 


Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser 
                565                 570                 575     


Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp 
            580                 585                 590         


Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg 
        595                 600                 605             


Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu 
    610                 615                 620                 


Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val 
625                 630                 635                 640 


Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser 
                645                 650                 655     


Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu 
            660                 665                 670         


Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys 
        675                 680                 685             


Ile Leu Met Gly Thr Lys Glu His Gly Gly Gly Gly Gly Ser Gly Gly 
    690                 695                 700                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Cys Asp 
705                 710                 715                 720 


Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser 
                725                 730                 735     


Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu 
            740                 745                 750         


Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys 
        755                 760                 765             


Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu 
    770                 775                 780                 


Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser 
785                 790                 795                 800 


Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg 
                805                 810                 815     


Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu 
            820                 825                 830         


Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu 
        835                 840                 845             


Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met 
    850                 855                 860                 


Gly Thr Lys Glu His Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
865                 870                 875                 880 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Cys Asp Ile Glu Gly 
                885                 890                 895     


Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln 
            900                 905                 910         


Leu Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu 
        915                 920                 925             


Phe Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met 
    930                 935                 940                 


Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn 
945                 950                 955                 960 


Ser Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr 
                965                 970                 975     


Thr Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala 
            980                 985                 990         


Ala Leu Gly Glu Ala Gln Pro Thr  Lys Ser Leu Glu Glu  Asn Lys Ser 
        995                 1000                 1005             


Leu Lys  Glu Gln Lys Lys Leu  Asn Asp Leu Cys Phe  Leu Lys Arg 
    1010                 1015                 1020             


Leu Leu  Gln Glu Ile Lys Thr  Cys Trp Asn Lys Ile  Leu Met Gly 
    1025                 1030                 1035             


Thr Lys  Glu His Gly Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1040                 1045                 1050             


Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser Asp Cys  Asp Ile Glu 
    1055                 1060                 1065             


Gly Lys  Asp Gly Lys Gln Tyr  Glu Ser Val Leu Met  Val Ser Ile 
    1070                 1075                 1080             


Asp Gln  Leu Leu Asp Ser Met  Lys Glu Ile Gly Ser  Asn Cys Leu 
    1085                 1090                 1095             


Asn Asn  Glu Phe Asn Phe Phe  Lys Arg His Ile Cys  Asp Ala Asn 
    1100                 1105                 1110             


Lys Glu  Gly Met Phe Leu Phe  Arg Ala Ala Arg Lys  Leu Arg Gln 
    1115                 1120                 1125             


Phe Leu  Lys Met Asn Ser Thr  Gly Asp Phe Asp Leu  His Leu Leu 
    1130                 1135                 1140             


Lys Val  Ser Glu Gly Thr Thr  Ile Leu Leu Asn Cys  Thr Gly Gln 
    1145                 1150                 1155             


Val Lys  Gly Arg Lys Pro Ala  Ala Leu Gly Glu Ala  Gln Pro Thr 
    1160                 1165                 1170             


Lys Ser  Leu Glu Glu Asn Lys  Ser Leu Lys Glu Gln  Lys Lys Leu 
    1175                 1180                 1185             


Asn Asp  Leu Cys Phe Leu Lys  Arg Leu Leu Gln Glu  Ile Lys Thr 
    1190                 1195                 1200             


Cys Trp  Asn Lys Ile Leu Met  Gly Thr Lys Glu His  Gly Gly Gly 
    1205                 1210                 1215             


Gly Gly  Ser Gly Gly Gly Gly  Ser Gly Gly Gly Gly  Ser Gly Gly 
    1220                 1225                 1230             


Gly Gly  Ser Asp Cys Asp Ile  Glu Gly Lys Asp Gly  Lys Gln Tyr 
    1235                 1240                 1245             


Glu Ser  Val Leu Met Val Ser  Ile Asp Gln Leu Leu  Asp Ser Met 
    1250                 1255                 1260             


Lys Glu  Ile Gly Ser Asn Cys  Leu Asn Asn Glu Phe  Asn Phe Phe 
    1265                 1270                 1275             


Lys Arg  His Ile Cys Asp Ala  Asn Lys Glu Gly Met  Phe Leu Phe 
    1280                 1285                 1290             


Arg Ala  Ala Arg Lys Leu Arg  Gln Phe Leu Lys Met  Asn Ser Thr 
    1295                 1300                 1305             


Gly Asp  Phe Asp Leu His Leu  Leu Lys Val Ser Glu  Gly Thr Thr 
    1310                 1315                 1320             


Ile Leu  Leu Asn Cys Thr Gly  Gln Val Lys Gly Arg  Lys Pro Ala 
    1325                 1330                 1335             


Ala Leu  Gly Glu Ala Gln Pro  Thr Lys Ser Leu Glu  Glu Asn Lys 
    1340                 1345                 1350             


Ser Leu  Lys Glu Gln Lys Lys  Leu Asn Asp Leu Cys  Phe Leu Lys 
    1355                 1360                 1365             


Arg Leu  Leu Gln Glu Ile Lys  Thr Cys Trp Asn Lys  Ile Leu Met 
    1370                 1375                 1380             


Gly Thr  Lys Glu His 
    1385             


<210>  22
<211>  523
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain trivalent IL-7

<400>  22

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Gly Gly Gly Gly Ser Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys 
        195                 200                 205             


Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser 
    210                 215                 220                 


Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe 
225                 230                 235                 240 


Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg 
                245                 250                 255     


Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp 
            260                 265                 270         


Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu 
        275                 280                 285             


Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu 
    290                 295                 300                 


Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln 
305                 310                 315                 320 


Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile 
                325                 330                 335     


Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His Gly Gly 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Gly Gly Ser Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu 
    370                 375                 380                 


Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu 
385                 390                 395                 400 


Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His 
                405                 410                 415     


Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg 
            420                 425                 430         


Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu 
        435                 440                 445             


His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr 
    450                 455                 460                 


Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro 
465                 470                 475                 480 


Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu 
                485                 490                 495     


Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys 
            500                 505                 510         


Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His 
        515                 520             


<210>  23
<211>  552
<212>  PRT
<213>  Artificial

<220>
<223>  Dimer of this sequence linked by disulfides at positions 179 and 
       182

<400>  23

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr 
                165                 170                 175     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
            180                 185                 190         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        195                 200                 205             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    210                 215                 220                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
225                 230                 235                 240 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                245                 250                 255     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            260                 265                 270         


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        275                 280                 285             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    290                 295                 300                 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
305                 310                 315                 320 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                325                 330                 335     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            340                 345                 350         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        355                 360                 365             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    370                 375                 380                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
            420                 425                 430         


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
        435                 440                 445             


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr 
    450                 455                 460                 


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
465                 470                 475                 480 


Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn 
                485                 490                 495     


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val 
            500                 505                 510         


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
        515                 520                 525             


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys 
    530                 535                 540                 


Gln Ser Ile Ile Ser Thr Leu Thr 
545                 550         


<210>  24
<211>  858
<212>  PRT
<213>  Artificial

<220>
<223>  Dimer of this sequence linked by disulfides at positions 332 and 
       335

<400>  24

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr 
                165                 170                 175     


Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu 
            180                 185                 190         


Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys 
        195                 200                 205             


Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr 
    210                 215                 220                 


Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu 
225                 230                 235                 240 


Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg 
                245                 250                 255     


Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser 
            260                 265                 270         


Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val 
        275                 280                 285             


Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr 
    290                 295                 300                 


Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                325                 330                 335     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            340                 345                 350         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        355                 360                 365             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    370                 375                 380                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
385                 390                 395                 400 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                405                 410                 415     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            420                 425                 430         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        435                 440                 445             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    450                 455                 460                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
465                 470                 475                 480 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                485                 490                 495     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            500                 505                 510         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        515                 520                 525             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    530                 535                 540                 


Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 
545                 550                 555                 560 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser 
                565                 570                 575     


Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp 
            580                 585                 590         


Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu 
        595                 600                 605             


Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu 
    610                 615                 620                 


Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu 
625                 630                 635                 640 


Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp 
                645                 650                 655     


Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu 
            660                 665                 670         


Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu 
        675                 680                 685             


Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu 
    690                 695                 700                 


Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
705                 710                 715                 720 


Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln 
                725                 730                 735     


Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly 
            740                 745                 750         


Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys 
        755                 760                 765             


Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu 
    770                 775                 780                 


Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser 
785                 790                 795                 800 


Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val 
                805                 810                 815     


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr 
            820                 825                 830         


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
        835                 840                 845             


Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr 
    850                 855             


<210>  25
<211>  595
<212>  PRT
<213>  Artificial

<220>
<223>  Dimer of this sequence linked by disulfides at positions 203 and 
       206

<400>  25

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            180                 185                 190         


Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        195                 200                 205             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    210                 215                 220                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
225                 230                 235                 240 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                245                 250                 255     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            260                 265                 270         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        275                 280                 285             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    290                 295                 300                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
305                 310                 315                 320 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                325                 330                 335     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            340                 345                 350         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        355                 360                 365             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    370                 375                 380                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
385                 390                 395                 400 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                405                 410                 415     


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            420                 425                 430         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Cys Asp Ile Glu 
        435                 440                 445             


Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp 
    450                 455                 460                 


Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn 
465                 470                 475                 480 


Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly 
                485                 490                 495     


Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met 
            500                 505                 510         


Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly 
        515                 520                 525             


Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro 
    530                 535                 540                 


Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys 
545                 550                 555                 560 


Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg 
                565                 570                 575     


Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr 
            580                 585                 590         


Lys Glu His 
        595 


<210>  26
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 
1               5                   10                  15      


Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 
            20                  25                  30          


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
        35                  40                  45              


Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr 
    50                  55                  60                  


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
65                  70                  75                  80  


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
                85                  90                  95      


Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
            100                 105                 110         


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
        115                 120                 125             


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
    130                 135                 140                 


Arg Glu Lys Tyr Ser Lys Cys Ser Ser 
145                 150             


<210>  27
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  27

His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser 
1               5                   10                  15      


Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile 
            20                  25                  30          


Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala 
        35                  40                  45              


Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg 
    50                  55                  60                  


Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile 
65                  70                  75                  80  


Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu 
                85                  90                  95      


Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe 
            100                 105                 110         


Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser 
        115                 120                 125             


Ser 
    


<210>  28
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Leu Leu Ala Met Val Leu Thr Ser Ala Leu Leu Leu Cys Ser Val 
1               5                   10                  15      


Ala Gly Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe 
            20                  25                  30          


Leu Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser 
        35                  40                  45              


Ala Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys 
    50                  55                  60                  


Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr 
65                  70                  75                  80  


Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val 
                85                  90                  95      


Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro 
            100                 105                 110         


Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu 
        115                 120                 125             


Leu Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile 
    130                 135                 140                 


<210>  29
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  29

Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe Leu Ile 
1               5                   10                  15      


Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser Ala Asn 
            20                  25                  30          


Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys Thr Arg 
        35                  40                  45              


Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr Met Gln 
    50                  55                  60                  


Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val Glu Val 
65                  70                  75                  80  


Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro Cys Asn 
                85                  90                  95      


Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu Leu Glu 
            100                 105                 110         


Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile 
        115                 120                 125     


<210>  30
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210>  31
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  31

Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys 
1               5                   10                  15      


Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu 
            20                  25                  30          


Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser 
        35                  40                  45              


Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
    50                  55                  60                  


Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp 
65                  70                  75                  80  


Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn 
                85                  90                  95      


Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
            100                 105                 110         


Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
        115                 120                 125             


Phe Ile Asn Thr Ser 
    130             


<210>  32
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 
1               5                   10                  15      


Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 
            20                  25                  30          


Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 
        35                  40                  45              


Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 
    50                  55                  60                  


Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 
65                  70                  75                  80  


Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 
                85                  90                  95      


Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 
            100                 105                 110         


Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 
        115                 120                 125             


Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 
    130                 135                 140                 


Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu 
145                 150                 155                 160 


Asp Ser 
        


<210>  33
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  33

His Lys Ser Ser Ser Gln Gly Gln Asp Arg His Met Ile Arg Met Arg 
1               5                   10                  15      


Gln Leu Ile Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu 
            20                  25                  30          


Val Pro Glu Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu 
        35                  40                  45              


Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn 
    50                  55                  60                  


Thr Gly Asn Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys 
65                  70                  75                  80  


Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu 
                85                  90                  95      


Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe 
            100                 105                 110         


Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu 
        115                 120                 125             


Ser Ser Arg Thr His Gly Ser Glu Asp Ser 
    130                 135             


<210>  34
<211>  453
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain trivalent IL-4

<400>  34

Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 
1               5                   10                  15      


Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 
            20                  25                  30          


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
        35                  40                  45              


Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr 
    50                  55                  60                  


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
65                  70                  75                  80  


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
                85                  90                  95      


Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
            100                 105                 110         


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
        115                 120                 125             


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
    130                 135                 140                 


Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Lys 
                165                 170                 175     


Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr 
            180                 185                 190         


Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile Phe Ala 
        195                 200                 205             


Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr 
    210                 215                 220                 


Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu 
225                 230                 235                 240 


Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe 
                245                 250                 255     


Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser 
            260                 265                 270         


Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu 
        275                 280                 285             


Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly 
    290                 295                 300                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
305                 310                 315                 320 


Gly Gly Gly Ser His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys 
                325                 330                 335     


Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr 
            340                 345                 350         


Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr 
        355                 360                 365             


Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu 
    370                 375                 380                 


Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His 
385                 390                 395                 400 


Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly 
                405                 410                 415     


Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr 
            420                 425                 430         


Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr 
        435                 440                 445             


Ser Lys Cys Ser Ser 
    450             


<210>  35
<211>  603
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain tetravalent IL-4

<400>  35

Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 
1               5                   10                  15      


Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 
            20                  25                  30          


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
        35                  40                  45              


Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr 
    50                  55                  60                  


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
65                  70                  75                  80  


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
                85                  90                  95      


Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
            100                 105                 110         


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
        115                 120                 125             


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
    130                 135                 140                 


Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Lys 
                165                 170                 175     


Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr 
            180                 185                 190         


Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile Phe Ala 
        195                 200                 205             


Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr 
    210                 215                 220                 


Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu 
225                 230                 235                 240 


Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe 
                245                 250                 255     


Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser 
            260                 265                 270         


Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu 
        275                 280                 285             


Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly 
    290                 295                 300                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
305                 310                 315                 320 


Gly Gly Gly Ser His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys 
                325                 330                 335     


Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr 
            340                 345                 350         


Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr 
        355                 360                 365             


Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu 
    370                 375                 380                 


Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His 
385                 390                 395                 400 


Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly 
                405                 410                 415     


Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr 
            420                 425                 430         


Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr 
        435                 440                 445             


Ser Lys Cys Ser Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Lys Cys Asp Ile Thr 
465                 470                 475                 480 


Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr 
                485                 490                 495     


Leu Cys Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn 
            500                 505                 510         


Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln 
        515                 520                 525             


Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala 
    530                 535                 540                 


Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu 
545                 550                 555                 560 


Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys 
                565                 570                 575     


Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr 
            580                 585                 590         


Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser Ser 
        595                 600             


<210>  36
<211>  753
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain pentavalent IL-4

<400>  36

Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 
1               5                   10                  15      


Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 
            20                  25                  30          


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
        35                  40                  45              


Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr 
    50                  55                  60                  


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
65                  70                  75                  80  


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
                85                  90                  95      


Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
            100                 105                 110         


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
        115                 120                 125             


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
    130                 135                 140                 


Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Lys 
                165                 170                 175     


Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr 
            180                 185                 190         


Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile Phe Ala 
        195                 200                 205             


Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr 
    210                 215                 220                 


Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu 
225                 230                 235                 240 


Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe 
                245                 250                 255     


Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser 
            260                 265                 270         


Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu 
        275                 280                 285             


Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly 
    290                 295                 300                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
305                 310                 315                 320 


Gly Gly Gly Ser His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys 
                325                 330                 335     


Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr 
            340                 345                 350         


Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr 
        355                 360                 365             


Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu 
    370                 375                 380                 


Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His 
385                 390                 395                 400 


Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly 
                405                 410                 415     


Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr 
            420                 425                 430         


Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr 
        435                 440                 445             


Ser Lys Cys Ser Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Lys Cys Asp Ile Thr 
465                 470                 475                 480 


Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr 
                485                 490                 495     


Leu Cys Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn 
            500                 505                 510         


Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln 
        515                 520                 525             


Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala 
    530                 535                 540                 


Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu 
545                 550                 555                 560 


Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys 
                565                 570                 575     


Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr 
            580                 585                 590         


Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Gly Gly Gly 
        595                 600                 605             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    610                 615                 620                 


His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser 
625                 630                 635                 640 


Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile 
                645                 650                 655     


Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala 
            660                 665                 670         


Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg 
        675                 680                 685             


Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile 
    690                 695                 700                 


Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu 
705                 710                 715                 720 


Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe 
                725                 730                 735     


Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser 
            740                 745                 750         


Ser 
    


<210>  37
<211>  903
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain hexavalent IL-4

<400>  37

Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 
1               5                   10                  15      


Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 
            20                  25                  30          


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
        35                  40                  45              


Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr 
    50                  55                  60                  


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
65                  70                  75                  80  


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
                85                  90                  95      


Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
            100                 105                 110         


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
        115                 120                 125             


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
    130                 135                 140                 


Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Lys 
                165                 170                 175     


Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr 
            180                 185                 190         


Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile Phe Ala 
        195                 200                 205             


Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr 
    210                 215                 220                 


Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu 
225                 230                 235                 240 


Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe 
                245                 250                 255     


Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser 
            260                 265                 270         


Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu 
        275                 280                 285             


Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly 
    290                 295                 300                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
305                 310                 315                 320 


Gly Gly Gly Ser His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys 
                325                 330                 335     


Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr 
            340                 345                 350         


Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr 
        355                 360                 365             


Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu 
    370                 375                 380                 


Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His 
385                 390                 395                 400 


Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly 
                405                 410                 415     


Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr 
            420                 425                 430         


Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr 
        435                 440                 445             


Ser Lys Cys Ser Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Lys Cys Asp Ile Thr 
465                 470                 475                 480 


Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr 
                485                 490                 495     


Leu Cys Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn 
            500                 505                 510         


Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln 
        515                 520                 525             


Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala 
    530                 535                 540                 


Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu 
545                 550                 555                 560 


Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys 
                565                 570                 575     


Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr 
            580                 585                 590         


Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Gly Gly Gly 
        595                 600                 605             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    610                 615                 620                 


His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser 
625                 630                 635                 640 


Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile 
                645                 650                 655     


Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala 
            660                 665                 670         


Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg 
        675                 680                 685             


Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile 
    690                 695                 700                 


Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu 
705                 710                 715                 720 


Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe 
                725                 730                 735     


Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser 
            740                 745                 750         


Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        755                 760                 765             


Ser Gly Gly Gly Gly Ser His Lys Cys Asp Ile Thr Leu Gln Glu Ile 
    770                 775                 780                 


Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu 
785                 790                 795                 800 


Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys 
                805                 810                 815     


Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr Ser His 
            820                 825                 830         


His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe His 
        835                 840                 845             


Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu 
    850                 855                 860                 


Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala Asn Gln 
865                 870                 875                 880 


Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met Arg Glu 
                885                 890                 895     


Lys Tyr Ser Lys Cys Ser Ser 
            900             


<210>  38
<211>  1053
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain heptavalent IL-4

<400>  38

Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 
1               5                   10                  15      


Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 
            20                  25                  30          


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
        35                  40                  45              


Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr 
    50                  55                  60                  


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
65                  70                  75                  80  


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
                85                  90                  95      


Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
            100                 105                 110         


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
        115                 120                 125             


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
    130                 135                 140                 


Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Lys 
                165                 170                 175     


Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr 
            180                 185                 190         


Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile Phe Ala 
        195                 200                 205             


Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr 
    210                 215                 220                 


Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu 
225                 230                 235                 240 


Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe 
                245                 250                 255     


Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser 
            260                 265                 270         


Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu 
        275                 280                 285             


Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly 
    290                 295                 300                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
305                 310                 315                 320 


Gly Gly Gly Ser His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys 
                325                 330                 335     


Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr 
            340                 345                 350         


Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr 
        355                 360                 365             


Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu 
    370                 375                 380                 


Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His 
385                 390                 395                 400 


Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly 
                405                 410                 415     


Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr 
            420                 425                 430         


Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr 
        435                 440                 445             


Ser Lys Cys Ser Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Lys Cys Asp Ile Thr 
465                 470                 475                 480 


Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr 
                485                 490                 495     


Leu Cys Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn 
            500                 505                 510         


Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln 
        515                 520                 525             


Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala 
    530                 535                 540                 


Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu 
545                 550                 555                 560 


Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys 
                565                 570                 575     


Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr 
            580                 585                 590         


Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Gly Gly Gly 
        595                 600                 605             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    610                 615                 620                 


His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser 
625                 630                 635                 640 


Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile 
                645                 650                 655     


Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala 
            660                 665                 670         


Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg 
        675                 680                 685             


Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile 
    690                 695                 700                 


Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu 
705                 710                 715                 720 


Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe 
                725                 730                 735     


Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser 
            740                 745                 750         


Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        755                 760                 765             


Ser Gly Gly Gly Gly Ser His Lys Cys Asp Ile Thr Leu Gln Glu Ile 
    770                 775                 780                 


Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu 
785                 790                 795                 800 


Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys 
                805                 810                 815     


Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr Ser His 
            820                 825                 830         


His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe His 
        835                 840                 845             


Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu 
    850                 855                 860                 


Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala Asn Gln 
865                 870                 875                 880 


Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met Arg Glu 
                885                 890                 895     


Lys Tyr Ser Lys Cys Ser Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly 
            900                 905                 910         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Lys Cys Asp 
        915                 920                 925             


Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln 
    930                 935                 940                 


Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser 
945                 950                 955                 960 


Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
                965                 970                 975     


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            980                 985                 990         


Thr Ala Gln Gln Phe His Arg His  Lys Gln Leu Ile Arg  Phe Leu Lys 
        995                 1000                 1005             


Arg Leu  Asp Arg Asn Leu Trp  Gly Leu Ala Gly Leu  Asn Ser Cys 
    1010                 1015                 1020             


Pro Val  Lys Glu Ala Asn Gln  Ser Thr Leu Glu Asn  Phe Leu Glu 
    1025                 1030                 1035             


Arg Leu  Lys Thr Ile Met Arg  Glu Lys Tyr Ser Lys  Cys Ser Ser 
    1040                 1045                 1050             


<210>  39
<211>  1203
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain octavalent IL-4

<400>  39

Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 
1               5                   10                  15      


Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 
            20                  25                  30          


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
        35                  40                  45              


Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr 
    50                  55                  60                  


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
65                  70                  75                  80  


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
                85                  90                  95      


Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
            100                 105                 110         


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
        115                 120                 125             


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
    130                 135                 140                 


Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Lys 
                165                 170                 175     


Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr 
            180                 185                 190         


Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile Phe Ala 
        195                 200                 205             


Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr 
    210                 215                 220                 


Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu 
225                 230                 235                 240 


Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe 
                245                 250                 255     


Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser 
            260                 265                 270         


Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu 
        275                 280                 285             


Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly 
    290                 295                 300                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
305                 310                 315                 320 


Gly Gly Gly Ser His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys 
                325                 330                 335     


Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr 
            340                 345                 350         


Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr 
        355                 360                 365             


Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu 
    370                 375                 380                 


Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His 
385                 390                 395                 400 


Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly 
                405                 410                 415     


Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr 
            420                 425                 430         


Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr 
        435                 440                 445             


Ser Lys Cys Ser Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Lys Cys Asp Ile Thr 
465                 470                 475                 480 


Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr 
                485                 490                 495     


Leu Cys Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn 
            500                 505                 510         


Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln 
        515                 520                 525             


Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala 
    530                 535                 540                 


Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu 
545                 550                 555                 560 


Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys 
                565                 570                 575     


Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr 
            580                 585                 590         


Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Gly Gly Gly 
        595                 600                 605             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    610                 615                 620                 


His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser 
625                 630                 635                 640 


Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile 
                645                 650                 655     


Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala 
            660                 665                 670         


Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg 
        675                 680                 685             


Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile 
    690                 695                 700                 


Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu 
705                 710                 715                 720 


Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe 
                725                 730                 735     


Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser 
            740                 745                 750         


Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        755                 760                 765             


Ser Gly Gly Gly Gly Ser His Lys Cys Asp Ile Thr Leu Gln Glu Ile 
    770                 775                 780                 


Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu 
785                 790                 795                 800 


Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys 
                805                 810                 815     


Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr Ser His 
            820                 825                 830         


His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe His 
        835                 840                 845             


Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu 
    850                 855                 860                 


Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala Asn Gln 
865                 870                 875                 880 


Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met Arg Glu 
                885                 890                 895     


Lys Tyr Ser Lys Cys Ser Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly 
            900                 905                 910         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Lys Cys Asp 
        915                 920                 925             


Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln 
    930                 935                 940                 


Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser 
945                 950                 955                 960 


Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
                965                 970                 975     


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            980                 985                 990         


Thr Ala Gln Gln Phe His Arg His  Lys Gln Leu Ile Arg  Phe Leu Lys 
        995                 1000                 1005             


Arg Leu  Asp Arg Asn Leu Trp  Gly Leu Ala Gly Leu  Asn Ser Cys 
    1010                 1015                 1020             


Pro Val  Lys Glu Ala Asn Gln  Ser Thr Leu Glu Asn  Phe Leu Glu 
    1025                 1030                 1035             


Arg Leu  Lys Thr Ile Met Arg  Glu Lys Tyr Ser Lys  Cys Ser Ser 
    1040                 1045                 1050             


Gly Gly  Gly Gly Gly Ser Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1055                 1060                 1065             


Ser Gly  Gly Gly Gly Ser His  Lys Cys Asp Ile Thr  Leu Gln Glu 
    1070                 1075                 1080             


Ile Ile  Lys Thr Leu Asn Ser  Leu Thr Glu Gln Lys  Thr Leu Cys 
    1085                 1090                 1095             


Thr Glu  Leu Thr Val Thr Asp  Ile Phe Ala Ala Ser  Lys Asn Thr 
    1100                 1105                 1110             


Thr Glu  Lys Glu Thr Phe Cys  Arg Ala Ala Thr Val  Leu Arg Gln 
    1115                 1120                 1125             


Phe Tyr  Ser His His Glu Lys  Asp Thr Arg Cys Leu  Gly Ala Thr 
    1130                 1135                 1140             


Ala Gln  Gln Phe His Arg His  Lys Gln Leu Ile Arg  Phe Leu Lys 
    1145                 1150                 1155             


Arg Leu  Asp Arg Asn Leu Trp  Gly Leu Ala Gly Leu  Asn Ser Cys 
    1160                 1165                 1170             


Pro Val  Lys Glu Ala Asn Gln  Ser Thr Leu Glu Asn  Phe Leu Glu 
    1175                 1180                 1185             


Arg Leu  Lys Thr Ile Met Arg  Glu Lys Tyr Ser Lys  Cys Ser Ser 
    1190                 1195                 1200             


<210>  40
<211>  438
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain trivalent IL-9

<400>  40

Met Leu Leu Ala Met Val Leu Thr Ser Ala Leu Leu Leu Cys Ser Val 
1               5                   10                  15      


Ala Gly Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe 
            20                  25                  30          


Leu Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser 
        35                  40                  45              


Ala Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys 
    50                  55                  60                  


Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr 
65                  70                  75                  80  


Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val 
                85                  90                  95      


Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro 
            100                 105                 110         


Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu 
        115                 120                 125             


Leu Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile 
    130                 135                 140                 


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp 
                165                 170                 175     


Ile Asn Phe Leu Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys 
            180                 185                 190         


His Cys Ser Ala Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser 
        195                 200                 205             


Asp Asn Cys Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr 
    210                 215                 220                 


Asn Thr Thr Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys 
225                 230                 235                 240 


Lys Ser Val Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys 
                245                 250                 255     


Glu Gln Pro Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu 
            260                 265                 270         


Lys Ser Leu Leu Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg 
        275                 280                 285             


Gly Lys Ile Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Gly Cys Pro Thr Leu Ala Gly 
305                 310                 315                 320 


Ile Leu Asp Ile Asn Phe Leu Ile Asn Lys Met Gln Glu Asp Pro Ala 
                325                 330                 335     


Ser Lys Cys His Cys Ser Ala Asn Val Thr Ser Cys Leu Cys Leu Gly 
            340                 345                 350         


Ile Pro Ser Asp Asn Cys Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser 
        355                 360                 365             


Gln Met Thr Asn Thr Thr Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser 
    370                 375                 380                 


Arg Val Lys Lys Ser Val Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr 
385                 390                 395                 400 


Phe Ser Cys Glu Gln Pro Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu 
                405                 410                 415     


Thr Phe Leu Lys Ser Leu Leu Glu Ile Phe Gln Lys Glu Lys Met Arg 
            420                 425                 430         


Gly Met Arg Gly Lys Ile 
        435             


<210>  41
<211>  585
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain tetravalent IL-9

<400>  41

Met Leu Leu Ala Met Val Leu Thr Ser Ala Leu Leu Leu Cys Ser Val 
1               5                   10                  15      


Ala Gly Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe 
            20                  25                  30          


Leu Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser 
        35                  40                  45              


Ala Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys 
    50                  55                  60                  


Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr 
65                  70                  75                  80  


Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val 
                85                  90                  95      


Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro 
            100                 105                 110         


Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu 
        115                 120                 125             


Leu Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile 
    130                 135                 140                 


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp 
                165                 170                 175     


Ile Asn Phe Leu Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys 
            180                 185                 190         


His Cys Ser Ala Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser 
        195                 200                 205             


Asp Asn Cys Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr 
    210                 215                 220                 


Asn Thr Thr Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys 
225                 230                 235                 240 


Lys Ser Val Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys 
                245                 250                 255     


Glu Gln Pro Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu 
            260                 265                 270         


Lys Ser Leu Leu Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg 
        275                 280                 285             


Gly Lys Ile Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Gly Cys Pro Thr Leu Ala Gly 
305                 310                 315                 320 


Ile Leu Asp Ile Asn Phe Leu Ile Asn Lys Met Gln Glu Asp Pro Ala 
                325                 330                 335     


Ser Lys Cys His Cys Ser Ala Asn Val Thr Ser Cys Leu Cys Leu Gly 
            340                 345                 350         


Ile Pro Ser Asp Asn Cys Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser 
        355                 360                 365             


Gln Met Thr Asn Thr Thr Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser 
    370                 375                 380                 


Arg Val Lys Lys Ser Val Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr 
385                 390                 395                 400 


Phe Ser Cys Glu Gln Pro Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu 
                405                 410                 415     


Thr Phe Leu Lys Ser Leu Leu Glu Ile Phe Gln Lys Glu Lys Met Arg 
            420                 425                 430         


Gly Met Arg Gly Lys Ile Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Gly Cys Pro Thr 
    450                 455                 460                 


Leu Ala Gly Ile Leu Asp Ile Asn Phe Leu Ile Asn Lys Met Gln Glu 
465                 470                 475                 480 


Asp Pro Ala Ser Lys Cys His Cys Ser Ala Asn Val Thr Ser Cys Leu 
                485                 490                 495     


Cys Leu Gly Ile Pro Ser Asp Asn Cys Thr Arg Pro Cys Phe Ser Glu 
            500                 505                 510         


Arg Leu Ser Gln Met Thr Asn Thr Thr Met Gln Thr Arg Tyr Pro Leu 
        515                 520                 525             


Ile Phe Ser Arg Val Lys Lys Ser Val Glu Val Leu Lys Asn Asn Lys 
    530                 535                 540                 


Cys Pro Tyr Phe Ser Cys Glu Gln Pro Cys Asn Gln Thr Thr Ala Gly 
545                 550                 555                 560 


Asn Ala Leu Thr Phe Leu Lys Ser Leu Leu Glu Ile Phe Gln Lys Glu 
                565                 570                 575     


Lys Met Arg Gly Met Arg Gly Lys Ile 
            580                 585 


<210>  42
<211>  732
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain pentavalent IL-9

<400>  42

Met Leu Leu Ala Met Val Leu Thr Ser Ala Leu Leu Leu Cys Ser Val 
1               5                   10                  15      


Ala Gly Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe 
            20                  25                  30          


Leu Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser 
        35                  40                  45              


Ala Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys 
    50                  55                  60                  


Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr 
65                  70                  75                  80  


Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val 
                85                  90                  95      


Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro 
            100                 105                 110         


Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu 
        115                 120                 125             


Leu Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile 
    130                 135                 140                 


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp 
                165                 170                 175     


Ile Asn Phe Leu Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys 
            180                 185                 190         


His Cys Ser Ala Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser 
        195                 200                 205             


Asp Asn Cys Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr 
    210                 215                 220                 


Asn Thr Thr Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys 
225                 230                 235                 240 


Lys Ser Val Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys 
                245                 250                 255     


Glu Gln Pro Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu 
            260                 265                 270         


Lys Ser Leu Leu Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg 
        275                 280                 285             


Gly Lys Ile Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Gly Cys Pro Thr Leu Ala Gly 
305                 310                 315                 320 


Ile Leu Asp Ile Asn Phe Leu Ile Asn Lys Met Gln Glu Asp Pro Ala 
                325                 330                 335     


Ser Lys Cys His Cys Ser Ala Asn Val Thr Ser Cys Leu Cys Leu Gly 
            340                 345                 350         


Ile Pro Ser Asp Asn Cys Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser 
        355                 360                 365             


Gln Met Thr Asn Thr Thr Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser 
    370                 375                 380                 


Arg Val Lys Lys Ser Val Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr 
385                 390                 395                 400 


Phe Ser Cys Glu Gln Pro Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu 
                405                 410                 415     


Thr Phe Leu Lys Ser Leu Leu Glu Ile Phe Gln Lys Glu Lys Met Arg 
            420                 425                 430         


Gly Met Arg Gly Lys Ile Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Gly Cys Pro Thr 
    450                 455                 460                 


Leu Ala Gly Ile Leu Asp Ile Asn Phe Leu Ile Asn Lys Met Gln Glu 
465                 470                 475                 480 


Asp Pro Ala Ser Lys Cys His Cys Ser Ala Asn Val Thr Ser Cys Leu 
                485                 490                 495     


Cys Leu Gly Ile Pro Ser Asp Asn Cys Thr Arg Pro Cys Phe Ser Glu 
            500                 505                 510         


Arg Leu Ser Gln Met Thr Asn Thr Thr Met Gln Thr Arg Tyr Pro Leu 
        515                 520                 525             


Ile Phe Ser Arg Val Lys Lys Ser Val Glu Val Leu Lys Asn Asn Lys 
    530                 535                 540                 


Cys Pro Tyr Phe Ser Cys Glu Gln Pro Cys Asn Gln Thr Thr Ala Gly 
545                 550                 555                 560 


Asn Ala Leu Thr Phe Leu Lys Ser Leu Leu Glu Ile Phe Gln Lys Glu 
                565                 570                 575     


Lys Met Arg Gly Met Arg Gly Lys Ile Gly Gly Gly Gly Gly Ser Gly 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Gly 
        595                 600                 605             


Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe Leu Ile Asn Lys 
    610                 615                 620                 


Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser Ala Asn Val Thr 
625                 630                 635                 640 


Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys Thr Arg Pro Cys 
                645                 650                 655     


Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr Met Gln Thr Arg 
            660                 665                 670         


Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val Glu Val Leu Lys 
        675                 680                 685             


Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro Cys Asn Gln Thr 
    690                 695                 700                 


Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu Leu Glu Ile Phe 
705                 710                 715                 720 


Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile 
                725                 730         


<210>  43
<211>  879
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain hexavalent IL-9

<400>  43

Met Leu Leu Ala Met Val Leu Thr Ser Ala Leu Leu Leu Cys Ser Val 
1               5                   10                  15      


Ala Gly Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe 
            20                  25                  30          


Leu Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser 
        35                  40                  45              


Ala Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys 
    50                  55                  60                  


Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr 
65                  70                  75                  80  


Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val 
                85                  90                  95      


Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro 
            100                 105                 110         


Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu 
        115                 120                 125             


Leu Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile 
    130                 135                 140                 


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp 
                165                 170                 175     


Ile Asn Phe Leu Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys 
            180                 185                 190         


His Cys Ser Ala Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser 
        195                 200                 205             


Asp Asn Cys Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr 
    210                 215                 220                 


Asn Thr Thr Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys 
225                 230                 235                 240 


Lys Ser Val Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys 
                245                 250                 255     


Glu Gln Pro Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu 
            260                 265                 270         


Lys Ser Leu Leu Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg 
        275                 280                 285             


Gly Lys Ile Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Gly Cys Pro Thr Leu Ala Gly 
305                 310                 315                 320 


Ile Leu Asp Ile Asn Phe Leu Ile Asn Lys Met Gln Glu Asp Pro Ala 
                325                 330                 335     


Ser Lys Cys His Cys Ser Ala Asn Val Thr Ser Cys Leu Cys Leu Gly 
            340                 345                 350         


Ile Pro Ser Asp Asn Cys Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser 
        355                 360                 365             


Gln Met Thr Asn Thr Thr Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser 
    370                 375                 380                 


Arg Val Lys Lys Ser Val Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr 
385                 390                 395                 400 


Phe Ser Cys Glu Gln Pro Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu 
                405                 410                 415     


Thr Phe Leu Lys Ser Leu Leu Glu Ile Phe Gln Lys Glu Lys Met Arg 
            420                 425                 430         


Gly Met Arg Gly Lys Ile Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Gly Cys Pro Thr 
    450                 455                 460                 


Leu Ala Gly Ile Leu Asp Ile Asn Phe Leu Ile Asn Lys Met Gln Glu 
465                 470                 475                 480 


Asp Pro Ala Ser Lys Cys His Cys Ser Ala Asn Val Thr Ser Cys Leu 
                485                 490                 495     


Cys Leu Gly Ile Pro Ser Asp Asn Cys Thr Arg Pro Cys Phe Ser Glu 
            500                 505                 510         


Arg Leu Ser Gln Met Thr Asn Thr Thr Met Gln Thr Arg Tyr Pro Leu 
        515                 520                 525             


Ile Phe Ser Arg Val Lys Lys Ser Val Glu Val Leu Lys Asn Asn Lys 
    530                 535                 540                 


Cys Pro Tyr Phe Ser Cys Glu Gln Pro Cys Asn Gln Thr Thr Ala Gly 
545                 550                 555                 560 


Asn Ala Leu Thr Phe Leu Lys Ser Leu Leu Glu Ile Phe Gln Lys Glu 
                565                 570                 575     


Lys Met Arg Gly Met Arg Gly Lys Ile Gly Gly Gly Gly Gly Ser Gly 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Gly 
        595                 600                 605             


Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe Leu Ile Asn Lys 
    610                 615                 620                 


Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser Ala Asn Val Thr 
625                 630                 635                 640 


Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys Thr Arg Pro Cys 
                645                 650                 655     


Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr Met Gln Thr Arg 
            660                 665                 670         


Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val Glu Val Leu Lys 
        675                 680                 685             


Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro Cys Asn Gln Thr 
    690                 695                 700                 


Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu Leu Glu Ile Phe 
705                 710                 715                 720 


Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile Gly Gly Gly Gly 
                725                 730                 735     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            740                 745                 750         


Ser Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe Leu 
        755                 760                 765             


Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser Ala 
    770                 775                 780                 


Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys Thr 
785                 790                 795                 800 


Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr Met 
                805                 810                 815     


Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val Glu 
            820                 825                 830         


Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro Cys 
        835                 840                 845             


Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu Leu 
    850                 855                 860                 


Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile 
865                 870                 875                 


<210>  44
<211>  1026
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain heptavalent IL-9

<400>  44

Met Leu Leu Ala Met Val Leu Thr Ser Ala Leu Leu Leu Cys Ser Val 
1               5                   10                  15      


Ala Gly Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe 
            20                  25                  30          


Leu Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser 
        35                  40                  45              


Ala Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys 
    50                  55                  60                  


Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr 
65                  70                  75                  80  


Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val 
                85                  90                  95      


Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro 
            100                 105                 110         


Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu 
        115                 120                 125             


Leu Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile 
    130                 135                 140                 


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp 
                165                 170                 175     


Ile Asn Phe Leu Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys 
            180                 185                 190         


His Cys Ser Ala Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser 
        195                 200                 205             


Asp Asn Cys Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr 
    210                 215                 220                 


Asn Thr Thr Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys 
225                 230                 235                 240 


Lys Ser Val Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys 
                245                 250                 255     


Glu Gln Pro Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu 
            260                 265                 270         


Lys Ser Leu Leu Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg 
        275                 280                 285             


Gly Lys Ile Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Gly Cys Pro Thr Leu Ala Gly 
305                 310                 315                 320 


Ile Leu Asp Ile Asn Phe Leu Ile Asn Lys Met Gln Glu Asp Pro Ala 
                325                 330                 335     


Ser Lys Cys His Cys Ser Ala Asn Val Thr Ser Cys Leu Cys Leu Gly 
            340                 345                 350         


Ile Pro Ser Asp Asn Cys Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser 
        355                 360                 365             


Gln Met Thr Asn Thr Thr Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser 
    370                 375                 380                 


Arg Val Lys Lys Ser Val Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr 
385                 390                 395                 400 


Phe Ser Cys Glu Gln Pro Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu 
                405                 410                 415     


Thr Phe Leu Lys Ser Leu Leu Glu Ile Phe Gln Lys Glu Lys Met Arg 
            420                 425                 430         


Gly Met Arg Gly Lys Ile Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Gly Cys Pro Thr 
    450                 455                 460                 


Leu Ala Gly Ile Leu Asp Ile Asn Phe Leu Ile Asn Lys Met Gln Glu 
465                 470                 475                 480 


Asp Pro Ala Ser Lys Cys His Cys Ser Ala Asn Val Thr Ser Cys Leu 
                485                 490                 495     


Cys Leu Gly Ile Pro Ser Asp Asn Cys Thr Arg Pro Cys Phe Ser Glu 
            500                 505                 510         


Arg Leu Ser Gln Met Thr Asn Thr Thr Met Gln Thr Arg Tyr Pro Leu 
        515                 520                 525             


Ile Phe Ser Arg Val Lys Lys Ser Val Glu Val Leu Lys Asn Asn Lys 
    530                 535                 540                 


Cys Pro Tyr Phe Ser Cys Glu Gln Pro Cys Asn Gln Thr Thr Ala Gly 
545                 550                 555                 560 


Asn Ala Leu Thr Phe Leu Lys Ser Leu Leu Glu Ile Phe Gln Lys Glu 
                565                 570                 575     


Lys Met Arg Gly Met Arg Gly Lys Ile Gly Gly Gly Gly Gly Ser Gly 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Gly 
        595                 600                 605             


Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe Leu Ile Asn Lys 
    610                 615                 620                 


Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser Ala Asn Val Thr 
625                 630                 635                 640 


Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys Thr Arg Pro Cys 
                645                 650                 655     


Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr Met Gln Thr Arg 
            660                 665                 670         


Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val Glu Val Leu Lys 
        675                 680                 685             


Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro Cys Asn Gln Thr 
    690                 695                 700                 


Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu Leu Glu Ile Phe 
705                 710                 715                 720 


Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile Gly Gly Gly Gly 
                725                 730                 735     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            740                 745                 750         


Ser Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe Leu 
        755                 760                 765             


Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser Ala 
    770                 775                 780                 


Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys Thr 
785                 790                 795                 800 


Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr Met 
                805                 810                 815     


Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val Glu 
            820                 825                 830         


Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro Cys 
        835                 840                 845             


Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu Leu 
    850                 855                 860                 


Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile Gly 
865                 870                 875                 880 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                885                 890                 895     


Gly Gly Gly Ser Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile 
            900                 905                 910         


Asn Phe Leu Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys His 
        915                 920                 925             


Cys Ser Ala Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp 
    930                 935                 940                 


Asn Cys Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr Asn 
945                 950                 955                 960 


Thr Thr Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys 
                965                 970                 975     


Ser Val Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu 
            980                 985                 990         


Gln Pro Cys Asn Gln Thr Thr Ala  Gly Asn Ala Leu Thr  Phe Leu Lys 
        995                 1000                 1005             


Ser Leu  Leu Glu Ile Phe Gln  Lys Glu Lys Met Arg  Gly Met Arg 
    1010                 1015                 1020             


Gly Lys  Ile 
    1025     


<210>  45
<211>  1173
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain octavalent IL-9

<400>  45

Met Leu Leu Ala Met Val Leu Thr Ser Ala Leu Leu Leu Cys Ser Val 
1               5                   10                  15      


Ala Gly Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe 
            20                  25                  30          


Leu Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser 
        35                  40                  45              


Ala Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys 
    50                  55                  60                  


Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr 
65                  70                  75                  80  


Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val 
                85                  90                  95      


Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro 
            100                 105                 110         


Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu 
        115                 120                 125             


Leu Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile 
    130                 135                 140                 


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp 
                165                 170                 175     


Ile Asn Phe Leu Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys 
            180                 185                 190         


His Cys Ser Ala Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser 
        195                 200                 205             


Asp Asn Cys Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr 
    210                 215                 220                 


Asn Thr Thr Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys 
225                 230                 235                 240 


Lys Ser Val Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys 
                245                 250                 255     


Glu Gln Pro Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu 
            260                 265                 270         


Lys Ser Leu Leu Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg 
        275                 280                 285             


Gly Lys Ile Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Gly Cys Pro Thr Leu Ala Gly 
305                 310                 315                 320 


Ile Leu Asp Ile Asn Phe Leu Ile Asn Lys Met Gln Glu Asp Pro Ala 
                325                 330                 335     


Ser Lys Cys His Cys Ser Ala Asn Val Thr Ser Cys Leu Cys Leu Gly 
            340                 345                 350         


Ile Pro Ser Asp Asn Cys Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser 
        355                 360                 365             


Gln Met Thr Asn Thr Thr Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser 
    370                 375                 380                 


Arg Val Lys Lys Ser Val Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr 
385                 390                 395                 400 


Phe Ser Cys Glu Gln Pro Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu 
                405                 410                 415     


Thr Phe Leu Lys Ser Leu Leu Glu Ile Phe Gln Lys Glu Lys Met Arg 
            420                 425                 430         


Gly Met Arg Gly Lys Ile Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Gly Cys Pro Thr 
    450                 455                 460                 


Leu Ala Gly Ile Leu Asp Ile Asn Phe Leu Ile Asn Lys Met Gln Glu 
465                 470                 475                 480 


Asp Pro Ala Ser Lys Cys His Cys Ser Ala Asn Val Thr Ser Cys Leu 
                485                 490                 495     


Cys Leu Gly Ile Pro Ser Asp Asn Cys Thr Arg Pro Cys Phe Ser Glu 
            500                 505                 510         


Arg Leu Ser Gln Met Thr Asn Thr Thr Met Gln Thr Arg Tyr Pro Leu 
        515                 520                 525             


Ile Phe Ser Arg Val Lys Lys Ser Val Glu Val Leu Lys Asn Asn Lys 
    530                 535                 540                 


Cys Pro Tyr Phe Ser Cys Glu Gln Pro Cys Asn Gln Thr Thr Ala Gly 
545                 550                 555                 560 


Asn Ala Leu Thr Phe Leu Lys Ser Leu Leu Glu Ile Phe Gln Lys Glu 
                565                 570                 575     


Lys Met Arg Gly Met Arg Gly Lys Ile Gly Gly Gly Gly Gly Ser Gly 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Gly 
        595                 600                 605             


Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe Leu Ile Asn Lys 
    610                 615                 620                 


Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser Ala Asn Val Thr 
625                 630                 635                 640 


Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys Thr Arg Pro Cys 
                645                 650                 655     


Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr Met Gln Thr Arg 
            660                 665                 670         


Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val Glu Val Leu Lys 
        675                 680                 685             


Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro Cys Asn Gln Thr 
    690                 695                 700                 


Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu Leu Glu Ile Phe 
705                 710                 715                 720 


Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile Gly Gly Gly Gly 
                725                 730                 735     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            740                 745                 750         


Ser Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe Leu 
        755                 760                 765             


Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser Ala 
    770                 775                 780                 


Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys Thr 
785                 790                 795                 800 


Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr Met 
                805                 810                 815     


Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val Glu 
            820                 825                 830         


Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro Cys 
        835                 840                 845             


Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu Leu 
    850                 855                 860                 


Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile Gly 
865                 870                 875                 880 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                885                 890                 895     


Gly Gly Gly Ser Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile 
            900                 905                 910         


Asn Phe Leu Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys His 
        915                 920                 925             


Cys Ser Ala Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp 
    930                 935                 940                 


Asn Cys Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr Asn 
945                 950                 955                 960 


Thr Thr Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys 
                965                 970                 975     


Ser Val Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu 
            980                 985                 990         


Gln Pro Cys Asn Gln Thr Thr Ala  Gly Asn Ala Leu Thr  Phe Leu Lys 
        995                 1000                 1005             


Ser Leu  Leu Glu Ile Phe Gln  Lys Glu Lys Met Arg  Gly Met Arg 
    1010                 1015                 1020             


Gly Lys  Ile Gly Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1025                 1030                 1035             


Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gln Gly Cys  Pro Thr Leu 
    1040                 1045                 1050             


Ala Gly  Ile Leu Asp Ile Asn  Phe Leu Ile Asn Lys  Met Gln Glu 
    1055                 1060                 1065             


Asp Pro  Ala Ser Lys Cys His  Cys Ser Ala Asn Val  Thr Ser Cys 
    1070                 1075                 1080             


Leu Cys  Leu Gly Ile Pro Ser  Asp Asn Cys Thr Arg  Pro Cys Phe 
    1085                 1090                 1095             


Ser Glu  Arg Leu Ser Gln Met  Thr Asn Thr Thr Met  Gln Thr Arg 
    1100                 1105                 1110             


Tyr Pro  Leu Ile Phe Ser Arg  Val Lys Lys Ser Val  Glu Val Leu 
    1115                 1120                 1125             


Lys Asn  Asn Lys Cys Pro Tyr  Phe Ser Cys Glu Gln  Pro Cys Asn 
    1130                 1135                 1140             


Gln Thr  Thr Ala Gly Asn Ala  Leu Thr Phe Leu Lys  Ser Leu Leu 
    1145                 1150                 1155             


Glu Ile  Phe Gln Lys Glu Lys  Met Arg Gly Met Arg  Gly Lys Ile 
    1160                 1165                 1170             


<210>  46
<211>  470
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain trivalent IL-15

<400>  46

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     


Gly Ser Gly Gly Gly Gly Ser Gly Ile His Val Phe Ile Leu Gly Cys 
            180                 185                 190         


Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile 
        195                 200                 205             


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
    210                 215                 220                 


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
225                 230                 235                 240 


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
                245                 250                 255     


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
            260                 265                 270         


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
        275                 280                 285             


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
    290                 295                 300                 


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                325                 330                 335     


Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro 
            340                 345                 350         


Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile 
        355                 360                 365             


Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu 
    370                 375                 380                 


Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu 
385                 390                 395                 400 


Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His 
                405                 410                 415     


Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser 
            420                 425                 430         


Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu 
        435                 440                 445             


Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln 
    450                 455                 460                 


Met Phe Ile Asn Thr Ser 
465                 470 


<210>  47
<211>  624
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain tetravalent IL-15

<400>  47

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     


Gly Ser Gly Gly Gly Gly Ser Gly Ile His Val Phe Ile Leu Gly Cys 
            180                 185                 190         


Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile 
        195                 200                 205             


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
    210                 215                 220                 


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
225                 230                 235                 240 


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
                245                 250                 255     


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
            260                 265                 270         


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
        275                 280                 285             


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
    290                 295                 300                 


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                325                 330                 335     


Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro 
            340                 345                 350         


Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile 
        355                 360                 365             


Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu 
    370                 375                 380                 


Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu 
385                 390                 395                 400 


Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His 
                405                 410                 415     


Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser 
            420                 425                 430         


Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu 
        435                 440                 445             


Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln 
    450                 455                 460                 


Met Phe Ile Asn Thr Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
465                 470                 475                 480 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ile His Val Phe 
                485                 490                 495     


Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp 
            500                 505                 510         


Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser 
        515                 520                 525             


Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser 
    530                 535                 540                 


Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile 
545                 550                 555                 560 


Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu 
                565                 570                 575     


Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu 
            580                 585                 590         


Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu 
        595                 600                 605             


Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
    610                 615                 620                 


<210>  48
<211>  778
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain pentavalent IL-15

<400>  48

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     


Gly Ser Gly Gly Gly Gly Ser Gly Ile His Val Phe Ile Leu Gly Cys 
            180                 185                 190         


Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile 
        195                 200                 205             


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
    210                 215                 220                 


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
225                 230                 235                 240 


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
                245                 250                 255     


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
            260                 265                 270         


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
        275                 280                 285             


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
    290                 295                 300                 


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                325                 330                 335     


Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro 
            340                 345                 350         


Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile 
        355                 360                 365             


Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu 
    370                 375                 380                 


Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu 
385                 390                 395                 400 


Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His 
                405                 410                 415     


Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser 
            420                 425                 430         


Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu 
        435                 440                 445             


Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln 
    450                 455                 460                 


Met Phe Ile Asn Thr Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
465                 470                 475                 480 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ile His Val Phe 
                485                 490                 495     


Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp 
            500                 505                 510         


Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser 
        515                 520                 525             


Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser 
    530                 535                 540                 


Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile 
545                 550                 555                 560 


Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu 
                565                 570                 575     


Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu 
            580                 585                 590         


Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu 
        595                 600                 605             


Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
    610                 615                 620                 


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
625                 630                 635                 640 


Gly Gly Gly Gly Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser 
                645                 650                 655     


Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp 
            660                 665                 670         


Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr 
        675                 680                 685             


Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met 
    690                 695                 700                 


Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp 
705                 710                 715                 720 


Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn 
                725                 730                 735     


Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys 
            740                 745                 750         


Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val 
        755                 760                 765             


His Ile Val Gln Met Phe Ile Asn Thr Ser 
    770                 775             


<210>  49
<211>  932
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain hexavalent IL-15

<400>  49

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     


Gly Ser Gly Gly Gly Gly Ser Gly Ile His Val Phe Ile Leu Gly Cys 
            180                 185                 190         


Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile 
        195                 200                 205             


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
    210                 215                 220                 


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
225                 230                 235                 240 


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
                245                 250                 255     


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
            260                 265                 270         


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
        275                 280                 285             


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
    290                 295                 300                 


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                325                 330                 335     


Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro 
            340                 345                 350         


Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile 
        355                 360                 365             


Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu 
    370                 375                 380                 


Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu 
385                 390                 395                 400 


Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His 
                405                 410                 415     


Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser 
            420                 425                 430         


Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu 
        435                 440                 445             


Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln 
    450                 455                 460                 


Met Phe Ile Asn Thr Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
465                 470                 475                 480 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ile His Val Phe 
                485                 490                 495     


Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp 
            500                 505                 510         


Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser 
        515                 520                 525             


Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser 
    530                 535                 540                 


Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile 
545                 550                 555                 560 


Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu 
                565                 570                 575     


Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu 
            580                 585                 590         


Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu 
        595                 600                 605             


Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
    610                 615                 620                 


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
625                 630                 635                 640 


Gly Gly Gly Gly Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser 
                645                 650                 655     


Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp 
            660                 665                 670         


Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr 
        675                 680                 685             


Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met 
    690                 695                 700                 


Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp 
705                 710                 715                 720 


Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn 
                725                 730                 735     


Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys 
            740                 745                 750         


Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val 
        755                 760                 765             


His Ile Val Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Gly Gly Ser 
    770                 775                 780                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
785                 790                 795                 800 


Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr 
                805                 810                 815     


Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            820                 825                 830         


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        835                 840                 845             


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    850                 855                 860                 


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
865                 870                 875                 880 


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                885                 890                 895     


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            900                 905                 910         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        915                 920                 925             


Ile Asn Thr Ser 
    930         


<210>  50
<211>  1086
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain heptavalent IL-15

<400>  50

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     


Gly Ser Gly Gly Gly Gly Ser Gly Ile His Val Phe Ile Leu Gly Cys 
            180                 185                 190         


Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile 
        195                 200                 205             


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
    210                 215                 220                 


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
225                 230                 235                 240 


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
                245                 250                 255     


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
            260                 265                 270         


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
        275                 280                 285             


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
    290                 295                 300                 


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                325                 330                 335     


Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro 
            340                 345                 350         


Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile 
        355                 360                 365             


Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu 
    370                 375                 380                 


Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu 
385                 390                 395                 400 


Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His 
                405                 410                 415     


Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser 
            420                 425                 430         


Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu 
        435                 440                 445             


Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln 
    450                 455                 460                 


Met Phe Ile Asn Thr Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
465                 470                 475                 480 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ile His Val Phe 
                485                 490                 495     


Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp 
            500                 505                 510         


Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser 
        515                 520                 525             


Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser 
    530                 535                 540                 


Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile 
545                 550                 555                 560 


Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu 
                565                 570                 575     


Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu 
            580                 585                 590         


Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu 
        595                 600                 605             


Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
    610                 615                 620                 


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
625                 630                 635                 640 


Gly Gly Gly Gly Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser 
                645                 650                 655     


Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp 
            660                 665                 670         


Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr 
        675                 680                 685             


Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met 
    690                 695                 700                 


Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp 
705                 710                 715                 720 


Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn 
                725                 730                 735     


Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys 
            740                 745                 750         


Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val 
        755                 760                 765             


His Ile Val Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Gly Gly Ser 
    770                 775                 780                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
785                 790                 795                 800 


Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr 
                805                 810                 815     


Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            820                 825                 830         


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        835                 840                 845             


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    850                 855                 860                 


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
865                 870                 875                 880 


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                885                 890                 895     


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            900                 905                 910         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        915                 920                 925             


Ile Asn Thr Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    930                 935                 940                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ile His Val Phe Ile Leu 
945                 950                 955                 960 


Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn 
                965                 970                 975     


Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His 
            980                 985                 990         


Ile Asp Ala Thr Leu Tyr Thr Glu  Ser Asp Val His Pro  Ser Cys Lys 
        995                 1000                 1005             


Val Thr  Ala Met Lys Cys Phe  Leu Leu Glu Leu Gln  Val Ile Ser 
    1010                 1015                 1020             


Leu Glu  Ser Gly Asp Ala Ser  Ile His Asp Thr Val  Glu Asn Leu 
    1025                 1030                 1035             


Ile Ile  Leu Ala Asn Asn Ser  Leu Ser Ser Asn Gly  Asn Val Thr 
    1040                 1045                 1050             


Glu Ser  Gly Cys Lys Glu Cys  Glu Glu Leu Glu Glu  Lys Asn Ile 
    1055                 1060                 1065             


Lys Glu  Phe Leu Gln Ser Phe  Val His Ile Val Gln  Met Phe Ile 
    1070                 1075                 1080             


Asn Thr  Ser 
    1085     


<210>  51
<211>  1240
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain octavalent IL-15

<400>  51

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     


Gly Ser Gly Gly Gly Gly Ser Gly Ile His Val Phe Ile Leu Gly Cys 
            180                 185                 190         


Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile 
        195                 200                 205             


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
    210                 215                 220                 


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
225                 230                 235                 240 


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
                245                 250                 255     


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
            260                 265                 270         


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
        275                 280                 285             


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
    290                 295                 300                 


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                325                 330                 335     


Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro 
            340                 345                 350         


Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile 
        355                 360                 365             


Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu 
    370                 375                 380                 


Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu 
385                 390                 395                 400 


Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His 
                405                 410                 415     


Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser 
            420                 425                 430         


Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu 
        435                 440                 445             


Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln 
    450                 455                 460                 


Met Phe Ile Asn Thr Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
465                 470                 475                 480 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ile His Val Phe 
                485                 490                 495     


Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp 
            500                 505                 510         


Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser 
        515                 520                 525             


Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser 
    530                 535                 540                 


Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile 
545                 550                 555                 560 


Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu 
                565                 570                 575     


Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu 
            580                 585                 590         


Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu 
        595                 600                 605             


Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
    610                 615                 620                 


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
625                 630                 635                 640 


Gly Gly Gly Gly Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser 
                645                 650                 655     


Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp 
            660                 665                 670         


Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr 
        675                 680                 685             


Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met 
    690                 695                 700                 


Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp 
705                 710                 715                 720 


Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn 
                725                 730                 735     


Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys 
            740                 745                 750         


Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val 
        755                 760                 765             


His Ile Val Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Gly Gly Ser 
    770                 775                 780                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
785                 790                 795                 800 


Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr 
                805                 810                 815     


Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            820                 825                 830         


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        835                 840                 845             


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    850                 855                 860                 


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
865                 870                 875                 880 


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                885                 890                 895     


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            900                 905                 910         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        915                 920                 925             


Ile Asn Thr Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    930                 935                 940                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ile His Val Phe Ile Leu 
945                 950                 955                 960 


Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn 
                965                 970                 975     


Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His 
            980                 985                 990         


Ile Asp Ala Thr Leu Tyr Thr Glu  Ser Asp Val His Pro  Ser Cys Lys 
        995                 1000                 1005             


Val Thr  Ala Met Lys Cys Phe  Leu Leu Glu Leu Gln  Val Ile Ser 
    1010                 1015                 1020             


Leu Glu  Ser Gly Asp Ala Ser  Ile His Asp Thr Val  Glu Asn Leu 
    1025                 1030                 1035             


Ile Ile  Leu Ala Asn Asn Ser  Leu Ser Ser Asn Gly  Asn Val Thr 
    1040                 1045                 1050             


Glu Ser  Gly Cys Lys Glu Cys  Glu Glu Leu Glu Glu  Lys Asn Ile 
    1055                 1060                 1065             


Lys Glu  Phe Leu Gln Ser Phe  Val His Ile Val Gln  Met Phe Ile 
    1070                 1075                 1080             


Asn Thr  Ser Gly Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1085                 1090                 1095             


Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly Ile His  Val Phe Ile 
    1100                 1105                 1110             


Leu Gly  Cys Phe Ser Ala Gly  Leu Pro Lys Thr Glu  Ala Asn Trp 
    1115                 1120                 1125             


Val Asn  Val Ile Ser Asp Leu  Lys Lys Ile Glu Asp  Leu Ile Gln 
    1130                 1135                 1140             


Ser Met  His Ile Asp Ala Thr  Leu Tyr Thr Glu Ser  Asp Val His 
    1145                 1150                 1155             


Pro Ser  Cys Lys Val Thr Ala  Met Lys Cys Phe Leu  Leu Glu Leu 
    1160                 1165                 1170             


Gln Val  Ile Ser Leu Glu Ser  Gly Asp Ala Ser Ile  His Asp Thr 
    1175                 1180                 1185             


Val Glu  Asn Leu Ile Ile Leu  Ala Asn Asn Ser Leu  Ser Ser Asn 
    1190                 1195                 1200             


Gly Asn  Val Thr Glu Ser Gly  Cys Lys Glu Cys Glu  Glu Leu Glu 
    1205                 1210                 1215             


Glu Lys  Asn Ile Lys Glu Phe  Leu Gln Ser Phe Val  His Ile Val 
    1220                 1225                 1230             


Gln Met  Phe Ile Asn Thr Ser  
    1235                 1240 


<210>  52
<211>  480
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain trivalent IL-21

<400>  52

Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 
1               5                   10                  15      


Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 
            20                  25                  30          


Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 
        35                  40                  45              


Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 
    50                  55                  60                  


Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 
65                  70                  75                  80  


Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 
                85                  90                  95      


Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 
            100                 105                 110         


Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 
        115                 120                 125             


Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 
    130                 135                 140                 


Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu 
145                 150                 155                 160 


Asp Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     


Gly Ser Gly Gly Gly Gly Ser His Lys Ser Ser Ser Gln Gly Gln Asp 
            180                 185                 190         


Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu 
        195                 200                 205             


Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu 
    210                 215                 220                 


Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys 
225                 230                 235                 240 


Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn 
                245                 250                 255     


Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly 
            260                 265                 270         


Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu 
        275                 280                 285             


Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln 
    290                 295                 300                 


Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                325                 330                 335     


Ser Gly Gly Gly Gly Ser His Lys Ser Ser Ser Gln Gly Gln Asp Arg 
            340                 345                 350         


His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu Lys 
        355                 360                 365             


Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu Asp 
    370                 375                 380                 


Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala 
385                 390                 395                 400 


Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn Val 
                405                 410                 415     


Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg 
            420                 425                 430         


Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys 
        435                 440                 445             


Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys 
    450                 455                 460                 


Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp Ser 
465                 470                 475                 480 


<210>  53
<211>  639
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain tetravalent IL-21

<400>  53

Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 
1               5                   10                  15      


Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 
            20                  25                  30          


Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 
        35                  40                  45              


Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 
    50                  55                  60                  


Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 
65                  70                  75                  80  


Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 
                85                  90                  95      


Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 
            100                 105                 110         


Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 
        115                 120                 125             


Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 
    130                 135                 140                 


Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu 
145                 150                 155                 160 


Asp Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     


Gly Ser Gly Gly Gly Gly Ser His Lys Ser Ser Ser Gln Gly Gln Asp 
            180                 185                 190         


Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu 
        195                 200                 205             


Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu 
    210                 215                 220                 


Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys 
225                 230                 235                 240 


Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn 
                245                 250                 255     


Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly 
            260                 265                 270         


Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu 
        275                 280                 285             


Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln 
    290                 295                 300                 


Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                325                 330                 335     


Ser Gly Gly Gly Gly Ser His Lys Ser Ser Ser Gln Gly Gln Asp Arg 
            340                 345                 350         


His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu Lys 
        355                 360                 365             


Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu Asp 
    370                 375                 380                 


Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala 
385                 390                 395                 400 


Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn Val 
                405                 410                 415     


Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg 
            420                 425                 430         


Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys 
        435                 440                 445             


Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys 
    450                 455                 460                 


Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp Ser 
465                 470                 475                 480 


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                485                 490                 495     


Gly Gly Gly Gly Ser His Lys Ser Ser Ser Gln Gly Gln Asp Arg His 
            500                 505                 510         


Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu Lys Asn 
        515                 520                 525             


Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu Asp Val 
    530                 535                 540                 


Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala Gln 
545                 550                 555                 560 


Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn Val Ser 
                565                 570                 575     


Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg Arg 
            580                 585                 590         


Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys Lys 
        595                 600                 605             


Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys Met 
    610                 615                 620                 


Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp Ser 
625                 630                 635                 


<210>  54
<211>  798
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain pentavalent IL-21

<400>  54

Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 
1               5                   10                  15      


Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 
            20                  25                  30          


Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 
        35                  40                  45              


Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 
    50                  55                  60                  


Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 
65                  70                  75                  80  


Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 
                85                  90                  95      


Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 
            100                 105                 110         


Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 
        115                 120                 125             


Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 
    130                 135                 140                 


Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu 
145                 150                 155                 160 


Asp Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     


Gly Ser Gly Gly Gly Gly Ser His Lys Ser Ser Ser Gln Gly Gln Asp 
            180                 185                 190         


Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu 
        195                 200                 205             


Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu 
    210                 215                 220                 


Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys 
225                 230                 235                 240 


Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn 
                245                 250                 255     


Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly 
            260                 265                 270         


Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu 
        275                 280                 285             


Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln 
    290                 295                 300                 


Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                325                 330                 335     


Ser Gly Gly Gly Gly Ser His Lys Ser Ser Ser Gln Gly Gln Asp Arg 
            340                 345                 350         


His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu Lys 
        355                 360                 365             


Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu Asp 
    370                 375                 380                 


Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala 
385                 390                 395                 400 


Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn Val 
                405                 410                 415     


Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg 
            420                 425                 430         


Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys 
        435                 440                 445             


Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys 
    450                 455                 460                 


Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp Ser 
465                 470                 475                 480 


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                485                 490                 495     


Gly Gly Gly Gly Ser His Lys Ser Ser Ser Gln Gly Gln Asp Arg His 
            500                 505                 510         


Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu Lys Asn 
        515                 520                 525             


Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu Asp Val 
    530                 535                 540                 


Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala Gln 
545                 550                 555                 560 


Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn Val Ser 
                565                 570                 575     


Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg Arg 
            580                 585                 590         


Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys Lys 
        595                 600                 605             


Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys Met 
    610                 615                 620                 


Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp Ser Gly 
625                 630                 635                 640 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                645                 650                 655     


Gly Gly Gly Ser His Lys Ser Ser Ser Gln Gly Gln Asp Arg His Met 
            660                 665                 670         


Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu Lys Asn Tyr 
        675                 680                 685             


Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu Asp Val Glu 
    690                 695                 700                 


Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala Gln Leu 
705                 710                 715                 720 


Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn Val Ser Ile 
                725                 730                 735     


Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg Arg Gln 
            740                 745                 750         


Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys Lys Pro 
        755                 760                 765             


Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys Met Ile 
    770                 775                 780                 


His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp Ser 
785                 790                 795             


<210>  55
<211>  957
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain hexavalent IL-21

<400>  55

Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 
1               5                   10                  15      


Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 
            20                  25                  30          


Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 
        35                  40                  45              


Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 
    50                  55                  60                  


Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 
65                  70                  75                  80  


Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 
                85                  90                  95      


Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 
            100                 105                 110         


Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 
        115                 120                 125             


Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 
    130                 135                 140                 


Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu 
145                 150                 155                 160 


Asp Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     


Gly Ser Gly Gly Gly Gly Ser His Lys Ser Ser Ser Gln Gly Gln Asp 
            180                 185                 190         


Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu 
        195                 200                 205             


Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu 
    210                 215                 220                 


Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys 
225                 230                 235                 240 


Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn 
                245                 250                 255     


Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly 
            260                 265                 270         


Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu 
        275                 280                 285             


Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln 
    290                 295                 300                 


Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                325                 330                 335     


Ser Gly Gly Gly Gly Ser His Lys Ser Ser Ser Gln Gly Gln Asp Arg 
            340                 345                 350         


His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu Lys 
        355                 360                 365             


Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu Asp 
    370                 375                 380                 


Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala 
385                 390                 395                 400 


Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn Val 
                405                 410                 415     


Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg 
            420                 425                 430         


Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys 
        435                 440                 445             


Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys 
    450                 455                 460                 


Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp Ser 
465                 470                 475                 480 


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                485                 490                 495     


Gly Gly Gly Gly Ser His Lys Ser Ser Ser Gln Gly Gln Asp Arg His 
            500                 505                 510         


Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu Lys Asn 
        515                 520                 525             


Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu Asp Val 
    530                 535                 540                 


Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala Gln 
545                 550                 555                 560 


Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn Val Ser 
                565                 570                 575     


Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg Arg 
            580                 585                 590         


Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys Lys 
        595                 600                 605             


Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys Met 
    610                 615                 620                 


Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp Ser Gly 
625                 630                 635                 640 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                645                 650                 655     


Gly Gly Gly Ser His Lys Ser Ser Ser Gln Gly Gln Asp Arg His Met 
            660                 665                 670         


Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu Lys Asn Tyr 
        675                 680                 685             


Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu Asp Val Glu 
    690                 695                 700                 


Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala Gln Leu 
705                 710                 715                 720 


Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn Val Ser Ile 
                725                 730                 735     


Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg Arg Gln 
            740                 745                 750         


Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys Lys Pro 
        755                 760                 765             


Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys Met Ile 
    770                 775                 780                 


His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp Ser Gly Gly 
785                 790                 795                 800 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                805                 810                 815     


Gly Gly Ser His Lys Ser Ser Ser Gln Gly Gln Asp Arg His Met Ile 
            820                 825                 830         


Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu Lys Asn Tyr Val 
        835                 840                 845             


Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu Asp Val Glu Thr 
    850                 855                 860                 


Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys 
865                 870                 875                 880 


Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn Val Ser Ile Lys 
                885                 890                 895     


Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys 
            900                 905                 910         


His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro 
        915                 920                 925             


Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys Met Ile His 
    930                 935                 940                 


Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp Ser 
945                 950                 955         


<210>  56
<211>  1116
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain heptavalent IL-21

<400>  56

Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 
1               5                   10                  15      


Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 
            20                  25                  30          


Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 
        35                  40                  45              


Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 
    50                  55                  60                  


Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 
65                  70                  75                  80  


Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 
                85                  90                  95      


Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 
            100                 105                 110         


Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 
        115                 120                 125             


Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 
    130                 135                 140                 


Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu 
145                 150                 155                 160 


Asp Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     


Gly Ser Gly Gly Gly Gly Ser His Lys Ser Ser Ser Gln Gly Gln Asp 
            180                 185                 190         


Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu 
        195                 200                 205             


Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu 
    210                 215                 220                 


Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys 
225                 230                 235                 240 


Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn 
                245                 250                 255     


Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly 
            260                 265                 270         


Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu 
        275                 280                 285             


Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln 
    290                 295                 300                 


Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                325                 330                 335     


Ser Gly Gly Gly Gly Ser His Lys Ser Ser Ser Gln Gly Gln Asp Arg 
            340                 345                 350         


His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu Lys 
        355                 360                 365             


Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu Asp 
    370                 375                 380                 


Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala 
385                 390                 395                 400 


Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn Val 
                405                 410                 415     


Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg 
            420                 425                 430         


Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys 
        435                 440                 445             


Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys 
    450                 455                 460                 


Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp Ser 
465                 470                 475                 480 


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                485                 490                 495     


Gly Gly Gly Gly Ser His Lys Ser Ser Ser Gln Gly Gln Asp Arg His 
            500                 505                 510         


Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu Lys Asn 
        515                 520                 525             


Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu Asp Val 
    530                 535                 540                 


Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala Gln 
545                 550                 555                 560 


Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn Val Ser 
                565                 570                 575     


Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg Arg 
            580                 585                 590         


Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys Lys 
        595                 600                 605             


Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys Met 
    610                 615                 620                 


Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp Ser Gly 
625                 630                 635                 640 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                645                 650                 655     


Gly Gly Gly Ser His Lys Ser Ser Ser Gln Gly Gln Asp Arg His Met 
            660                 665                 670         


Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu Lys Asn Tyr 
        675                 680                 685             


Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu Asp Val Glu 
    690                 695                 700                 


Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala Gln Leu 
705                 710                 715                 720 


Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn Val Ser Ile 
                725                 730                 735     


Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg Arg Gln 
            740                 745                 750         


Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys Lys Pro 
        755                 760                 765             


Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys Met Ile 
    770                 775                 780                 


His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp Ser Gly Gly 
785                 790                 795                 800 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                805                 810                 815     


Gly Gly Ser His Lys Ser Ser Ser Gln Gly Gln Asp Arg His Met Ile 
            820                 825                 830         


Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu Lys Asn Tyr Val 
        835                 840                 845             


Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu Asp Val Glu Thr 
    850                 855                 860                 


Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys 
865                 870                 875                 880 


Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn Val Ser Ile Lys 
                885                 890                 895     


Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys 
            900                 905                 910         


His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro 
        915                 920                 925             


Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys Met Ile His 
    930                 935                 940                 


Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp Ser Gly Gly Gly 
945                 950                 955                 960 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                965                 970                 975     


Gly Ser His Lys Ser Ser Ser Gln Gly Gln Asp Arg His Met Ile Arg 
            980                 985                 990         


Met Arg Gln Leu Ile Asp Ile Val  Asp Gln Leu Lys Asn  Tyr Val Asn 
        995                 1000                 1005             


Asp Leu  Val Pro Glu Phe Leu  Pro Ala Pro Glu Asp  Val Glu Thr 
    1010                 1015                 1020             


Asn Cys  Glu Trp Ser Ala Phe  Ser Cys Phe Gln Lys  Ala Gln Leu 
    1025                 1030                 1035             


Lys Ser  Ala Asn Thr Gly Asn  Asn Glu Arg Ile Ile  Asn Val Ser 
    1040                 1045                 1050             


Ile Lys  Lys Leu Lys Arg Lys  Pro Pro Ser Thr Asn  Ala Gly Arg 
    1055                 1060                 1065             


Arg Gln  Lys His Arg Leu Thr  Cys Pro Ser Cys Asp  Ser Tyr Glu 
    1070                 1075                 1080             


Lys Lys  Pro Pro Lys Glu Phe  Leu Glu Arg Phe Lys  Ser Leu Leu 
    1085                 1090                 1095             


Gln Lys  Met Ile His Gln His  Leu Ser Ser Arg Thr  His Gly Ser 
    1100                 1105                 1110             


Glu Asp  Ser 
    1115     


<210>  57
<211>  1275
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain octavalent IL-21

<400>  57

Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 
1               5                   10                  15      


Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 
            20                  25                  30          


Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 
        35                  40                  45              


Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 
    50                  55                  60                  


Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 
65                  70                  75                  80  


Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 
                85                  90                  95      


Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 
            100                 105                 110         


Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 
        115                 120                 125             


Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 
    130                 135                 140                 


Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu 
145                 150                 155                 160 


Asp Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     


Gly Ser Gly Gly Gly Gly Ser His Lys Ser Ser Ser Gln Gly Gln Asp 
            180                 185                 190         


Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu 
        195                 200                 205             


Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu 
    210                 215                 220                 


Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys 
225                 230                 235                 240 


Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn 
                245                 250                 255     


Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly 
            260                 265                 270         


Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu 
        275                 280                 285             


Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln 
    290                 295                 300                 


Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                325                 330                 335     


Ser Gly Gly Gly Gly Ser His Lys Ser Ser Ser Gln Gly Gln Asp Arg 
            340                 345                 350         


His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu Lys 
        355                 360                 365             


Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu Asp 
    370                 375                 380                 


Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala 
385                 390                 395                 400 


Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn Val 
                405                 410                 415     


Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg 
            420                 425                 430         


Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys 
        435                 440                 445             


Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys 
    450                 455                 460                 


Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp Ser 
465                 470                 475                 480 


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                485                 490                 495     


Gly Gly Gly Gly Ser His Lys Ser Ser Ser Gln Gly Gln Asp Arg His 
            500                 505                 510         


Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu Lys Asn 
        515                 520                 525             


Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu Asp Val 
    530                 535                 540                 


Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala Gln 
545                 550                 555                 560 


Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn Val Ser 
                565                 570                 575     


Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg Arg 
            580                 585                 590         


Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys Lys 
        595                 600                 605             


Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys Met 
    610                 615                 620                 


Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp Ser Gly 
625                 630                 635                 640 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                645                 650                 655     


Gly Gly Gly Ser His Lys Ser Ser Ser Gln Gly Gln Asp Arg His Met 
            660                 665                 670         


Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu Lys Asn Tyr 
        675                 680                 685             


Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu Asp Val Glu 
    690                 695                 700                 


Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala Gln Leu 
705                 710                 715                 720 


Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn Val Ser Ile 
                725                 730                 735     


Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg Arg Gln 
            740                 745                 750         


Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys Lys Pro 
        755                 760                 765             


Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys Met Ile 
    770                 775                 780                 


His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp Ser Gly Gly 
785                 790                 795                 800 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                805                 810                 815     


Gly Gly Ser His Lys Ser Ser Ser Gln Gly Gln Asp Arg His Met Ile 
            820                 825                 830         


Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu Lys Asn Tyr Val 
        835                 840                 845             


Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu Asp Val Glu Thr 
    850                 855                 860                 


Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys 
865                 870                 875                 880 


Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn Val Ser Ile Lys 
                885                 890                 895     


Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys 
            900                 905                 910         


His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro 
        915                 920                 925             


Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys Met Ile His 
    930                 935                 940                 


Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp Ser Gly Gly Gly 
945                 950                 955                 960 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                965                 970                 975     


Gly Ser His Lys Ser Ser Ser Gln Gly Gln Asp Arg His Met Ile Arg 
            980                 985                 990         


Met Arg Gln Leu Ile Asp Ile Val  Asp Gln Leu Lys Asn  Tyr Val Asn 
        995                 1000                 1005             


Asp Leu  Val Pro Glu Phe Leu  Pro Ala Pro Glu Asp  Val Glu Thr 
    1010                 1015                 1020             


Asn Cys  Glu Trp Ser Ala Phe  Ser Cys Phe Gln Lys  Ala Gln Leu 
    1025                 1030                 1035             


Lys Ser  Ala Asn Thr Gly Asn  Asn Glu Arg Ile Ile  Asn Val Ser 
    1040                 1045                 1050             


Ile Lys  Lys Leu Lys Arg Lys  Pro Pro Ser Thr Asn  Ala Gly Arg 
    1055                 1060                 1065             


Arg Gln  Lys His Arg Leu Thr  Cys Pro Ser Cys Asp  Ser Tyr Glu 
    1070                 1075                 1080             


Lys Lys  Pro Pro Lys Glu Phe  Leu Glu Arg Phe Lys  Ser Leu Leu 
    1085                 1090                 1095             


Gln Lys  Met Ile His Gln His  Leu Ser Ser Arg Thr  His Gly Ser 
    1100                 1105                 1110             


Glu Asp  Ser Gly Gly Gly Gly  Gly Ser Gly Gly Gly  Gly Ser Gly 
    1115                 1120                 1125             


Gly Gly  Gly Ser Gly Gly Gly  Gly Ser His Lys Ser  Ser Ser Gln 
    1130                 1135                 1140             


Gly Gln  Asp Arg His Met Ile  Arg Met Arg Gln Leu  Ile Asp Ile 
    1145                 1150                 1155             


Val Asp  Gln Leu Lys Asn Tyr  Val Asn Asp Leu Val  Pro Glu Phe 
    1160                 1165                 1170             


Leu Pro  Ala Pro Glu Asp Val  Glu Thr Asn Cys Glu  Trp Ser Ala 
    1175                 1180                 1185             


Phe Ser  Cys Phe Gln Lys Ala  Gln Leu Lys Ser Ala  Asn Thr Gly 
    1190                 1195                 1200             


Asn Asn  Glu Arg Ile Ile Asn  Val Ser Ile Lys Lys  Leu Lys Arg 
    1205                 1210                 1215             


Lys Pro  Pro Ser Thr Asn Ala  Gly Arg Arg Gln Lys  His Arg Leu 
    1220                 1225                 1230             


Thr Cys  Pro Ser Cys Asp Ser  Tyr Glu Lys Lys Pro  Pro Lys Glu 
    1235                 1240                 1245             


Phe Leu  Glu Arg Phe Lys Ser  Leu Leu Gln Lys Met  Ile His Gln 
    1250                 1255                 1260             


His Leu  Ser Ser Arg Thr His  Gly Ser Glu Asp Ser  
    1265                 1270                 1275 


<210>  58
<211>  549
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain, bivalent IL-4 with Fc hinge region (SEQ ID NO:16)

<400>  58

Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 
1               5                   10                  15      


Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 
            20                  25                  30          


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
        35                  40                  45              


Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr 
    50                  55                  60                  


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
65                  70                  75                  80  


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
                85                  90                  95      


Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
            100                 105                 110         


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
        115                 120                 125             


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
    130                 135                 140                 


Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys 
                165                 170                 175     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            180                 185                 190         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        195                 200                 205             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    210                 215                 220                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
225                 230                 235                 240 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                245                 250                 255     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            260                 265                 270         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        275                 280                 285             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    290                 295                 300                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
305                 310                 315                 320 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                325                 330                 335     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            340                 345                 350         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        355                 360                 365             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    370                 375                 380                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys 
            420                 425                 430         


Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr 
        435                 440                 445             


Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr 
    450                 455                 460                 


Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu 
465                 470                 475                 480 


Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His 
                485                 490                 495     


Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly 
            500                 505                 510         


Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr 
        515                 520                 525             


Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr 
    530                 535                 540                 


Ser Lys Cys Ser Ser 
545                 


<210>  59
<211>  549
<212>  PRT
<213>  Artificial

<220>
<223>  Dimer of this sequence linked by disulfides at positions 180 and 
       183

<400>  59

Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 
1               5                   10                  15      


Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 
            20                  25                  30          


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
        35                  40                  45              


Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr 
    50                  55                  60                  


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
65                  70                  75                  80  


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
                85                  90                  95      


Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
            100                 105                 110         


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
        115                 120                 125             


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
    130                 135                 140                 


Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys 
                165                 170                 175     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            180                 185                 190         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        195                 200                 205             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    210                 215                 220                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
225                 230                 235                 240 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                245                 250                 255     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            260                 265                 270         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        275                 280                 285             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    290                 295                 300                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
305                 310                 315                 320 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                325                 330                 335     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            340                 345                 350         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        355                 360                 365             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    370                 375                 380                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys 
            420                 425                 430         


Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr 
        435                 440                 445             


Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr 
    450                 455                 460                 


Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu 
465                 470                 475                 480 


Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His 
                485                 490                 495     


Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly 
            500                 505                 510         


Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr 
        515                 520                 525             


Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr 
    530                 535                 540                 


Ser Lys Cys Ser Ser 
545                 


<210>  60
<211>  849
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain, tetravalent IL-2 with Fc hinge region (SEQ ID 
       NO:16)

<400>  60

Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 
1               5                   10                  15      


Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 
            20                  25                  30          


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
        35                  40                  45              


Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr 
    50                  55                  60                  


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
65                  70                  75                  80  


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
                85                  90                  95      


Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
            100                 105                 110         


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
        115                 120                 125             


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
    130                 135                 140                 


Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Lys 
                165                 170                 175     


Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr 
            180                 185                 190         


Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile Phe Ala 
        195                 200                 205             


Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr 
    210                 215                 220                 


Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu 
225                 230                 235                 240 


Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe 
                245                 250                 255     


Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser 
            260                 265                 270         


Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu 
        275                 280                 285             


Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly 
    290                 295                 300                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
305                 310                 315                 320 


Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                325                 330                 335     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            340                 345                 350         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        355                 360                 365             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    370                 375                 380                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
385                 390                 395                 400 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                405                 410                 415     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            420                 425                 430         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        435                 440                 445             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    450                 455                 460                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
465                 470                 475                 480 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                485                 490                 495     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            500                 505                 510         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        515                 520                 525             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    530                 535                 540                 


Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
545                 550                 555                 560 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Lys Cys Asp Ile Thr 
                565                 570                 575     


Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr 
            580                 585                 590         


Leu Cys Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn 
        595                 600                 605             


Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln 
    610                 615                 620                 


Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala 
625                 630                 635                 640 


Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu 
                645                 650                 655     


Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys 
            660                 665                 670         


Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr 
        675                 680                 685             


Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Gly Gly Gly 
    690                 695                 700                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
705                 710                 715                 720 


His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser 
                725                 730                 735     


Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile 
            740                 745                 750         


Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala 
        755                 760                 765             


Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg 
    770                 775                 780                 


Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile 
785                 790                 795                 800 


Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu 
                805                 810                 815     


Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe 
            820                 825                 830         


Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser 
        835                 840                 845             


Ser 
    


<210>  61
<211>  849
<212>  PRT
<213>  Artificial

<220>
<223>  Dimer of this sequence linked by disulfides at positions 330 and 
       333

<400>  61

Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 
1               5                   10                  15      


Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 
            20                  25                  30          


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
        35                  40                  45              


Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr 
    50                  55                  60                  


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
65                  70                  75                  80  


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
                85                  90                  95      


Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
            100                 105                 110         


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
        115                 120                 125             


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
    130                 135                 140                 


Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Lys 
                165                 170                 175     


Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr 
            180                 185                 190         


Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile Phe Ala 
        195                 200                 205             


Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr 
    210                 215                 220                 


Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu 
225                 230                 235                 240 


Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe 
                245                 250                 255     


Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser 
            260                 265                 270         


Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu 
        275                 280                 285             


Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly 
    290                 295                 300                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
305                 310                 315                 320 


Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                325                 330                 335     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            340                 345                 350         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        355                 360                 365             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    370                 375                 380                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
385                 390                 395                 400 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                405                 410                 415     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            420                 425                 430         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        435                 440                 445             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    450                 455                 460                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
465                 470                 475                 480 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                485                 490                 495     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            500                 505                 510         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        515                 520                 525             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    530                 535                 540                 


Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
545                 550                 555                 560 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Lys Cys Asp Ile Thr 
                565                 570                 575     


Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr 
            580                 585                 590         


Leu Cys Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn 
        595                 600                 605             


Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln 
    610                 615                 620                 


Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala 
625                 630                 635                 640 


Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu 
                645                 650                 655     


Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys 
            660                 665                 670         


Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr 
        675                 680                 685             


Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Gly Gly Gly 
    690                 695                 700                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
705                 710                 715                 720 


His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser 
                725                 730                 735     


Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile 
            740                 745                 750         


Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala 
        755                 760                 765             


Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg 
    770                 775                 780                 


Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile 
785                 790                 795                 800 


Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu 
                805                 810                 815     


Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe 
            820                 825                 830         


Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser 
        835                 840                 845             


Ser 
    


<210>  62
<211>  537
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain, bivalent IL-9 with Fc hinge region (SEQ ID NO:16)

<400>  62

Met Leu Leu Ala Met Val Leu Thr Ser Ala Leu Leu Leu Cys Ser Val 
1               5                   10                  15      


Ala Gly Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe 
            20                  25                  30          


Leu Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser 
        35                  40                  45              


Ala Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys 
    50                  55                  60                  


Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr 
65                  70                  75                  80  


Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val 
                85                  90                  95      


Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro 
            100                 105                 110         


Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu 
        115                 120                 125             


Leu Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile 
    130                 135                 140                 


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                165                 170                 175     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            180                 185                 190         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        195                 200                 205             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    210                 215                 220                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
225                 230                 235                 240 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                245                 250                 255     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            260                 265                 270         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        275                 280                 285             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    290                 295                 300                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
305                 310                 315                 320 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                325                 330                 335     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            340                 345                 350         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        355                 360                 365             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    370                 375                 380                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Gly Cys Pro Thr 
                405                 410                 415     


Leu Ala Gly Ile Leu Asp Ile Asn Phe Leu Ile Asn Lys Met Gln Glu 
            420                 425                 430         


Asp Pro Ala Ser Lys Cys His Cys Ser Ala Asn Val Thr Ser Cys Leu 
        435                 440                 445             


Cys Leu Gly Ile Pro Ser Asp Asn Cys Thr Arg Pro Cys Phe Ser Glu 
    450                 455                 460                 


Arg Leu Ser Gln Met Thr Asn Thr Thr Met Gln Thr Arg Tyr Pro Leu 
465                 470                 475                 480 


Ile Phe Ser Arg Val Lys Lys Ser Val Glu Val Leu Lys Asn Asn Lys 
                485                 490                 495     


Cys Pro Tyr Phe Ser Cys Glu Gln Pro Cys Asn Gln Thr Thr Ala Gly 
            500                 505                 510         


Asn Ala Leu Thr Phe Leu Lys Ser Leu Leu Glu Ile Phe Gln Lys Glu 
        515                 520                 525             


Lys Met Arg Gly Met Arg Gly Lys Ile 
    530                 535         


<210>  63
<211>  537
<212>  PRT
<213>  Artificial

<220>
<223>  Dimer of this sequence linked by disulfides at positions 171 and 
       174

<400>  63

Met Leu Leu Ala Met Val Leu Thr Ser Ala Leu Leu Leu Cys Ser Val 
1               5                   10                  15      


Ala Gly Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe 
            20                  25                  30          


Leu Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser 
        35                  40                  45              


Ala Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys 
    50                  55                  60                  


Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr 
65                  70                  75                  80  


Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val 
                85                  90                  95      


Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro 
            100                 105                 110         


Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu 
        115                 120                 125             


Leu Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile 
    130                 135                 140                 


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                165                 170                 175     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            180                 185                 190         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        195                 200                 205             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    210                 215                 220                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
225                 230                 235                 240 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                245                 250                 255     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            260                 265                 270         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        275                 280                 285             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    290                 295                 300                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
305                 310                 315                 320 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                325                 330                 335     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            340                 345                 350         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        355                 360                 365             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    370                 375                 380                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Gly Cys Pro Thr 
                405                 410                 415     


Leu Ala Gly Ile Leu Asp Ile Asn Phe Leu Ile Asn Lys Met Gln Glu 
            420                 425                 430         


Asp Pro Ala Ser Lys Cys His Cys Ser Ala Asn Val Thr Ser Cys Leu 
        435                 440                 445             


Cys Leu Gly Ile Pro Ser Asp Asn Cys Thr Arg Pro Cys Phe Ser Glu 
    450                 455                 460                 


Arg Leu Ser Gln Met Thr Asn Thr Thr Met Gln Thr Arg Tyr Pro Leu 
465                 470                 475                 480 


Ile Phe Ser Arg Val Lys Lys Ser Val Glu Val Leu Lys Asn Asn Lys 
                485                 490                 495     


Cys Pro Tyr Phe Ser Cys Glu Gln Pro Cys Asn Gln Thr Thr Ala Gly 
            500                 505                 510         


Asn Ala Leu Thr Phe Leu Lys Ser Leu Leu Glu Ile Phe Gln Lys Glu 
        515                 520                 525             


Lys Met Arg Gly Met Arg Gly Lys Ile 
    530                 535         


<210>  64
<211>  831
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain, tetravalent IL-9 with Fc hinge region (SEQ ID 
       NO:16)

<400>  64

Met Leu Leu Ala Met Val Leu Thr Ser Ala Leu Leu Leu Cys Ser Val 
1               5                   10                  15      


Ala Gly Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe 
            20                  25                  30          


Leu Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser 
        35                  40                  45              


Ala Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys 
    50                  55                  60                  


Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr 
65                  70                  75                  80  


Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val 
                85                  90                  95      


Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro 
            100                 105                 110         


Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu 
        115                 120                 125             


Leu Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile 
    130                 135                 140                 


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp 
                165                 170                 175     


Ile Asn Phe Leu Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys 
            180                 185                 190         


His Cys Ser Ala Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser 
        195                 200                 205             


Asp Asn Cys Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr 
    210                 215                 220                 


Asn Thr Thr Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys 
225                 230                 235                 240 


Lys Ser Val Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys 
                245                 250                 255     


Glu Gln Pro Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu 
            260                 265                 270         


Lys Ser Leu Leu Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg 
        275                 280                 285             


Gly Lys Ile Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro 
305                 310                 315                 320 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                325                 330                 335     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            340                 345                 350         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        355                 360                 365             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    370                 375                 380                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
385                 390                 395                 400 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                405                 410                 415     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            420                 425                 430         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        435                 440                 445             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    450                 455                 460                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
465                 470                 475                 480 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                485                 490                 495     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            500                 505                 510         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        515                 520                 525             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly 
    530                 535                 540                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Gly 
545                 550                 555                 560 


Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe Leu Ile Asn Lys 
                565                 570                 575     


Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser Ala Asn Val Thr 
            580                 585                 590         


Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys Thr Arg Pro Cys 
        595                 600                 605             


Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr Met Gln Thr Arg 
    610                 615                 620                 


Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val Glu Val Leu Lys 
625                 630                 635                 640 


Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro Cys Asn Gln Thr 
                645                 650                 655     


Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu Leu Glu Ile Phe 
            660                 665                 670         


Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile Gly Gly Gly Gly 
        675                 680                 685             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    690                 695                 700                 


Ser Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe Leu 
705                 710                 715                 720 


Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser Ala 
                725                 730                 735     


Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys Thr 
            740                 745                 750         


Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr Met 
        755                 760                 765             


Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val Glu 
    770                 775                 780                 


Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro Cys 
785                 790                 795                 800 


Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu Leu 
                805                 810                 815     


Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile 
            820                 825                 830     


<210>  65
<211>  831
<212>  PRT
<213>  Artificial

<220>
<223>  Dimer of this sequence linked by disulfides at positions 318 and 
       321

<400>  65

Met Leu Leu Ala Met Val Leu Thr Ser Ala Leu Leu Leu Cys Ser Val 
1               5                   10                  15      


Ala Gly Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe 
            20                  25                  30          


Leu Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser 
        35                  40                  45              


Ala Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys 
    50                  55                  60                  


Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr 
65                  70                  75                  80  


Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val 
                85                  90                  95      


Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro 
            100                 105                 110         


Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu 
        115                 120                 125             


Leu Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile 
    130                 135                 140                 


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp 
                165                 170                 175     


Ile Asn Phe Leu Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys 
            180                 185                 190         


His Cys Ser Ala Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser 
        195                 200                 205             


Asp Asn Cys Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr 
    210                 215                 220                 


Asn Thr Thr Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys 
225                 230                 235                 240 


Lys Ser Val Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys 
                245                 250                 255     


Glu Gln Pro Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu 
            260                 265                 270         


Lys Ser Leu Leu Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg 
        275                 280                 285             


Gly Lys Ile Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro 
305                 310                 315                 320 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                325                 330                 335     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            340                 345                 350         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        355                 360                 365             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    370                 375                 380                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
385                 390                 395                 400 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                405                 410                 415     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            420                 425                 430         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        435                 440                 445             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    450                 455                 460                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
465                 470                 475                 480 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                485                 490                 495     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            500                 505                 510         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        515                 520                 525             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly 
    530                 535                 540                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Gly 
545                 550                 555                 560 


Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe Leu Ile Asn Lys 
                565                 570                 575     


Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser Ala Asn Val Thr 
            580                 585                 590         


Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys Thr Arg Pro Cys 
        595                 600                 605             


Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr Met Gln Thr Arg 
    610                 615                 620                 


Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val Glu Val Leu Lys 
625                 630                 635                 640 


Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro Cys Asn Gln Thr 
                645                 650                 655     


Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu Leu Glu Ile Phe 
            660                 665                 670         


Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile Gly Gly Gly Gly 
        675                 680                 685             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    690                 695                 700                 


Ser Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe Leu 
705                 710                 715                 720 


Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser Ala 
                725                 730                 735     


Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys Thr 
            740                 745                 750         


Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr Met 
        755                 760                 765             


Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val Glu 
    770                 775                 780                 


Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro Cys 
785                 790                 795                 800 


Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu Leu 
                805                 810                 815     


Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile 
            820                 825                 830     


<210>  66
<211>  562
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain, bivalent IL-15 with Fc hinge region (SEQ ID NO:16)

<400>  66

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     


Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
            180                 185                 190         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        195                 200                 205             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    210                 215                 220                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
225                 230                 235                 240 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                245                 250                 255     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            260                 265                 270         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        275                 280                 285             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    290                 295                 300                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
305                 310                 315                 320 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                325                 330                 335     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            340                 345                 350         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        355                 360                 365             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    370                 375                 380                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
385                 390                 395                 400 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ile His 
            420                 425                 430         


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        435                 440                 445             


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    450                 455                 460                 


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
465                 470                 475                 480 


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                485                 490                 495     


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            500                 505                 510         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        515                 520                 525             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    530                 535                 540                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
545                 550                 555                 560 


Thr Ser 
        


<210>  67
<211>  562
<212>  PRT
<213>  Artificial

<220>
<223>  Dimer of this sequence linked by disulfides at positions 189 and 
       192

<400>  67

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     


Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
            180                 185                 190         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        195                 200                 205             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    210                 215                 220                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
225                 230                 235                 240 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                245                 250                 255     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            260                 265                 270         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        275                 280                 285             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    290                 295                 300                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
305                 310                 315                 320 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                325                 330                 335     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            340                 345                 350         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        355                 360                 365             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    370                 375                 380                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
385                 390                 395                 400 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ile His 
            420                 425                 430         


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        435                 440                 445             


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    450                 455                 460                 


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
465                 470                 475                 480 


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                485                 490                 495     


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            500                 505                 510         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        515                 520                 525             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    530                 535                 540                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
545                 550                 555                 560 


Thr Ser 
        


<210>  68
<211>  870
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain, tetravalent IL-15 with Fc hinge region (SEQ ID 
       NO:16)

<400>  68

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     


Gly Ser Gly Gly Gly Gly Ser Gly Ile His Val Phe Ile Leu Gly Cys 
            180                 185                 190         


Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile 
        195                 200                 205             


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
    210                 215                 220                 


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
225                 230                 235                 240 


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
                245                 250                 255     


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
            260                 265                 270         


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
        275                 280                 285             


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
    290                 295                 300                 


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                325                 330                 335     


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
            340                 345                 350         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        355                 360                 365             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    370                 375                 380                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
385                 390                 395                 400 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                405                 410                 415     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            420                 425                 430         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
        435                 440                 445             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    450                 455                 460                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
465                 470                 475                 480 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                485                 490                 495     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            500                 505                 510         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        515                 520                 525             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    530                 535                 540                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
545                 550                 555                 560 


Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Gly Gly Gly Gly Ser Gly Ile His Val Phe Ile Leu Gly Cys 
            580                 585                 590         


Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile 
        595                 600                 605             


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
    610                 615                 620                 


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
625                 630                 635                 640 


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
                645                 650                 655     


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
            660                 665                 670         


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
        675                 680                 685             


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
    690                 695                 700                 


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Gly 
705                 710                 715                 720 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                725                 730                 735     


Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro 
            740                 745                 750         


Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile 
        755                 760                 765             


Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu 
    770                 775                 780                 


Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu 
785                 790                 795                 800 


Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His 
                805                 810                 815     


Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser 
            820                 825                 830         


Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu 
        835                 840                 845             


Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln 
    850                 855                 860                 


Met Phe Ile Asn Thr Ser 
865                 870 


<210>  69
<211>  870
<212>  PRT
<213>  Artificial

<220>
<223>  Dimer of this sequence linked by disulfides at positions 343 and 
       346

<400>  69

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     


Gly Ser Gly Gly Gly Gly Ser Gly Ile His Val Phe Ile Leu Gly Cys 
            180                 185                 190         


Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile 
        195                 200                 205             


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
    210                 215                 220                 


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
225                 230                 235                 240 


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
                245                 250                 255     


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
            260                 265                 270         


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
        275                 280                 285             


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
    290                 295                 300                 


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                325                 330                 335     


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
            340                 345                 350         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        355                 360                 365             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    370                 375                 380                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
385                 390                 395                 400 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                405                 410                 415     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            420                 425                 430         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
        435                 440                 445             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    450                 455                 460                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
465                 470                 475                 480 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                485                 490                 495     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            500                 505                 510         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        515                 520                 525             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    530                 535                 540                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
545                 550                 555                 560 


Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Gly Gly Gly Gly Ser Gly Ile His Val Phe Ile Leu Gly Cys 
            580                 585                 590         


Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile 
        595                 600                 605             


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
    610                 615                 620                 


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
625                 630                 635                 640 


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
                645                 650                 655     


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
            660                 665                 670         


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
        675                 680                 685             


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
    690                 695                 700                 


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Gly Gly Gly Gly 
705                 710                 715                 720 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                725                 730                 735     


Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro 
            740                 745                 750         


Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile 
        755                 760                 765             


Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu 
    770                 775                 780                 


Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu 
785                 790                 795                 800 


Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His 
                805                 810                 815     


Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser 
            820                 825                 830         


Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu 
        835                 840                 845             


Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln 
    850                 855                 860                 


Met Phe Ile Asn Thr Ser 
865                 870 


<210>  70
<211>  567
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain, bivalent IL-21 with Fc hinge region (SEQ ID NO:16)

<400>  70

Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 
1               5                   10                  15      


Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 
            20                  25                  30          


Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 
        35                  40                  45              


Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 
    50                  55                  60                  


Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 
65                  70                  75                  80  


Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 
                85                  90                  95      


Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 
            100                 105                 110         


Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 
        115                 120                 125             


Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 
    130                 135                 140                 


Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu 
145                 150                 155                 160 


Asp Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     


Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
            180                 185                 190         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        195                 200                 205             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    210                 215                 220                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
225                 230                 235                 240 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                245                 250                 255     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            260                 265                 270         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        275                 280                 285             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    290                 295                 300                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
305                 310                 315                 320 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                325                 330                 335     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            340                 345                 350         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        355                 360                 365             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    370                 375                 380                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
385                 390                 395                 400 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Lys Ser 
            420                 425                 430         


Ser Ser Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile 
        435                 440                 445             


Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu 
    450                 455                 460                 


Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala 
465                 470                 475                 480 


Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn 
                485                 490                 495     


Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro 
            500                 505                 510         


Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro 
        515                 520                 525             


Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg 
    530                 535                 540                 


Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg 
545                 550                 555                 560 


Thr His Gly Ser Glu Asp Ser 
                565         


<210>  71
<211>  567
<212>  PRT
<213>  Artificial

<220>
<223>  Dimer of this sequence linked by disulfides at positions 189 and 
       192

<400>  71

Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 
1               5                   10                  15      


Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 
            20                  25                  30          


Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 
        35                  40                  45              


Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 
    50                  55                  60                  


Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 
65                  70                  75                  80  


Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 
                85                  90                  95      


Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 
            100                 105                 110         


Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 
        115                 120                 125             


Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 
    130                 135                 140                 


Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu 
145                 150                 155                 160 


Asp Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     


Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
            180                 185                 190         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        195                 200                 205             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    210                 215                 220                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
225                 230                 235                 240 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                245                 250                 255     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            260                 265                 270         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        275                 280                 285             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    290                 295                 300                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
305                 310                 315                 320 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                325                 330                 335     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            340                 345                 350         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        355                 360                 365             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    370                 375                 380                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
385                 390                 395                 400 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Lys Ser 
            420                 425                 430         


Ser Ser Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile 
        435                 440                 445             


Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu 
    450                 455                 460                 


Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala 
465                 470                 475                 480 


Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn 
                485                 490                 495     


Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro 
            500                 505                 510         


Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro 
        515                 520                 525             


Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg 
    530                 535                 540                 


Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg 
545                 550                 555                 560 


Thr His Gly Ser Glu Asp Ser 
                565         


<210>  72
<211>  885
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain, tetravalent IL-21 with Fc hinge region (SEQ ID 
       NO:16)

<400>  72

Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 
1               5                   10                  15      


Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 
            20                  25                  30          


Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 
        35                  40                  45              


Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 
    50                  55                  60                  


Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 
65                  70                  75                  80  


Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 
                85                  90                  95      


Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 
            100                 105                 110         


Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 
        115                 120                 125             


Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 
    130                 135                 140                 


Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu 
145                 150                 155                 160 


Asp Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     


Gly Ser Gly Gly Gly Gly Ser His Lys Ser Ser Ser Gln Gly Gln Asp 
            180                 185                 190         


Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu 
        195                 200                 205             


Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu 
    210                 215                 220                 


Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys 
225                 230                 235                 240 


Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn 
                245                 250                 255     


Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly 
            260                 265                 270         


Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu 
        275                 280                 285             


Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln 
    290                 295                 300                 


Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                325                 330                 335     


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
            340                 345                 350         


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        355                 360                 365             


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    370                 375                 380                 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
385                 390                 395                 400 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                405                 410                 415     


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
            420                 425                 430         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        435                 440                 445             


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
    450                 455                 460                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
465                 470                 475                 480 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                485                 490                 495     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            500                 505                 510         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        515                 520                 525             


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    530                 535                 540                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
545                 550                 555                 560 


Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Lys Ser Ser 
            580                 585                 590         


Ser Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp 
        595                 600                 605             


Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe 
    610                 615                 620                 


Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe 
625                 630                 635                 640 


Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn 
                645                 650                 655     


Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro 
            660                 665                 670         


Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser 
        675                 680                 685             


Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe 
    690                 695                 700                 


Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr 
705                 710                 715                 720 


His Gly Ser Glu Asp Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                725                 730                 735     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Lys Ser Ser Ser 
            740                 745                 750         


Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile 
        755                 760                 765             


Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu 
    770                 775                 780                 


Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser 
785                 790                 795                 800 


Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu 
                805                 810                 815     


Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser 
            820                 825                 830         


Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys 
        835                 840                 845             


Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys 
    850                 855                 860                 


Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His 
865                 870                 875                 880 


Gly Ser Glu Asp Ser 
                885 


<210>  73
<211>  885
<212>  PRT
<213>  Artificial

<220>
<223>  Dimer of this sequence linked by disulfides at positions 348 and 
       351

<400>  73

Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 
1               5                   10                  15      


Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 
            20                  25                  30          


Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 
        35                  40                  45              


Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 
    50                  55                  60                  


Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 
65                  70                  75                  80  


Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 
                85                  90                  95      


Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 
            100                 105                 110         


Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 
        115                 120                 125             


Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 
    130                 135                 140                 


Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu 
145                 150                 155                 160 


Asp Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     


Gly Ser Gly Gly Gly Gly Ser His Lys Ser Ser Ser Gln Gly Gln Asp 
            180                 185                 190         


Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu 
        195                 200                 205             


Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu 
    210                 215                 220                 


Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys 
225                 230                 235                 240 


Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn 
                245                 250                 255     


Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly 
            260                 265                 270         


Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu 
        275                 280                 285             


Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln 
    290                 295                 300                 


Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                325                 330                 335     


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
            340                 345                 350         


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        355                 360                 365             


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    370                 375                 380                 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
385                 390                 395                 400 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                405                 410                 415     


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
            420                 425                 430         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        435                 440                 445             


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
    450                 455                 460                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
465                 470                 475                 480 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                485                 490                 495     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            500                 505                 510         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        515                 520                 525             


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    530                 535                 540                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
545                 550                 555                 560 


Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Lys Ser Ser 
            580                 585                 590         


Ser Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp 
        595                 600                 605             


Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe 
    610                 615                 620                 


Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe 
625                 630                 635                 640 


Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn 
                645                 650                 655     


Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro 
            660                 665                 670         


Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser 
        675                 680                 685             


Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe 
    690                 695                 700                 


Lys Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr 
705                 710                 715                 720 


His Gly Ser Glu Asp Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                725                 730                 735     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Lys Ser Ser Ser 
            740                 745                 750         


Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile 
        755                 760                 765             


Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu 
    770                 775                 780                 


Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser 
785                 790                 795                 800 


Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu 
                805                 810                 815     


Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser 
            820                 825                 830         


Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys 
        835                 840                 845             


Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys 
    850                 855                 860                 


Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His 
865                 870                 875                 880 


Gly Ser Glu Asp Ser 
                885 


<210>  74
<211>  942
<212>  PRT
<213>  Artificial

<220>
<223>  Single chain, tetravalent IL-7 with Fc hinge region (SEQ ID 
       NO:16)

<400>  74

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Gly Gly Gly Gly Ser Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys 
        195                 200                 205             


Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser 
    210                 215                 220                 


Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe 
225                 230                 235                 240 


Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg 
                245                 250                 255     


Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp 
            260                 265                 270         


Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu 
        275                 280                 285             


Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu 
    290                 295                 300                 


Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln 
305                 310                 315                 320 


Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile 
                325                 330                 335     


Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His Gly Gly 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
    370                 375                 380                 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
385                 390                 395                 400 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                405                 410                 415     


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            420                 425                 430         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        435                 440                 445             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    450                 455                 460                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
465                 470                 475                 480 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                485                 490                 495     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
            500                 505                 510         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        515                 520                 525             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    530                 535                 540                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
545                 550                 555                 560 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                565                 570                 575     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            580                 585                 590         


Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        595                 600                 605             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Cys Asp Ile Glu Gly Lys 
    610                 615                 620                 


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
625                 630                 635                 640 


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
                645                 650                 655     


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
            660                 665                 670         


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
        675                 680                 685             


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
    690                 695                 700                 


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
705                 710                 715                 720 


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
                725                 730                 735     


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
            740                 745                 750         


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
        755                 760                 765             


His Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    770                 775                 780                 


Ser Gly Gly Gly Gly Ser Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys 
785                 790                 795                 800 


Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser 
                805                 810                 815     


Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe 
            820                 825                 830         


Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg 
        835                 840                 845             


Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp 
    850                 855                 860                 


Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu 
865                 870                 875                 880 


Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu 
                885                 890                 895     


Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln 
            900                 905                 910         


Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile 
        915                 920                 925             


Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His 
    930                 935                 940         


<210>  75
<211>  942
<212>  PRT
<213>  Artificial

<220>
<223>  Dimer of this sequence linked by disulfides at positions 377 and 
       380

<400>  75

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Gly Gly Gly Gly Ser Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys 
        195                 200                 205             


Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser 
    210                 215                 220                 


Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe 
225                 230                 235                 240 


Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg 
                245                 250                 255     


Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp 
            260                 265                 270         


Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu 
        275                 280                 285             


Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu 
    290                 295                 300                 


Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln 
305                 310                 315                 320 


Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile 
                325                 330                 335     


Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His Gly Gly 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
    370                 375                 380                 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
385                 390                 395                 400 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                405                 410                 415     


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            420                 425                 430         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        435                 440                 445             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    450                 455                 460                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
465                 470                 475                 480 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                485                 490                 495     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
            500                 505                 510         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        515                 520                 525             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    530                 535                 540                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
545                 550                 555                 560 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                565                 570                 575     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            580                 585                 590         


Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        595                 600                 605             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Cys Asp Ile Glu Gly Lys 
    610                 615                 620                 


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
625                 630                 635                 640 


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
                645                 650                 655     


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
            660                 665                 670         


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
        675                 680                 685             


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
    690                 695                 700                 


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
705                 710                 715                 720 


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
                725                 730                 735     


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
            740                 745                 750         


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
        755                 760                 765             


His Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    770                 775                 780                 


Ser Gly Gly Gly Gly Ser Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys 
785                 790                 795                 800 


Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser 
                805                 810                 815     


Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe 
            820                 825                 830         


Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg 
        835                 840                 845             


Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp 
    850                 855                 860                 


Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu 
865                 870                 875                 880 


Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu 
                885                 890                 895     


Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln 
            900                 905                 910         


Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile 
        915                 920                 925             


Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His 
    930                 935                 940         


<210>  76
<211>  138
<212>  PRT
<213>  Artificial

<220>
<223>  IL-2 superkine

<400>  76

Met Gly Glu Phe Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
1               5                   10                  15      


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
            20                  25                  30          


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
        35                  40                  45              


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
    50                  55                  60                  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
65                  70                  75                  80  


Asn Phe His Phe Asp Pro Arg Asp Val Val Ser Asn Ile Asn Val Phe 
                85                  90                  95      


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
            100                 105                 110         


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
        115                 120                 125             


Cys Gln Ser Ile Ile Ser Thr Leu Thr His 
    130                 135             


