                         SEQUENCE LISTING

<110>  MAMMOTH BIOSCIENCES, INC.
 
<120>  CRISPR QUANTIFICATION

<130>  MABI-016/01WO 344183-2161

<150>  US 63/217,229
<151>  2021-06-30

<160>  73    

<170>  PatentIn version 3.5

<210>  1
<211>  1307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  1

Met Ala Asp Leu Ser Gln Phe Thr His Lys Tyr Gln Val Pro Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Leu Ser 
            20                  25                  30          


Ala Tyr Gly Met Val Ala Asp Asp Lys Gln Arg Ser Glu Asn Tyr Lys 
        35                  40                  45              


Lys Leu Lys Pro Val Ile Asp Arg Ile Tyr Lys Tyr Phe Ile Glu Glu 
    50                  55                  60                  


Ser Leu Lys Asn Thr Asn Leu Asp Trp Asn Pro Leu Tyr Glu Ala Ile 
65                  70                  75                  80  


Arg Glu Tyr Arg Lys Glu Lys Thr Thr Ala Thr Ile Thr Asn Leu Lys 
                85                  90                  95      


Glu Gln Gln Asp Ile Cys Arg Arg Ala Ile Ala Ser Arg Phe Glu Gly 
            100                 105                 110         


Lys Val Pro Asp Lys Gly Asp Lys Ser Val Lys Asp Phe Asn Lys Lys 
        115                 120                 125             


Gln Ser Lys Leu Phe Lys Glu Leu Phe Gly Lys Glu Leu Phe Thr Asp 
    130                 135                 140                 


Ser Val Leu Glu Gln Leu Pro Gly Val Ser Leu Ser Asp Glu Asp Lys 
145                 150                 155                 160 


Ala Leu Leu Lys Ser Phe Asp Lys Phe Thr Thr Tyr Phe Val Gly Phe 
                165                 170                 175     


Tyr Asp Asn Arg Lys Asn Val Phe Ser Ser Asp Asp Ile Ser Thr Gly 
            180                 185                 190         


Ile Pro His Arg Leu Val Gln Glu Asn Phe Pro Lys Phe Ile Asp Asn 
        195                 200                 205             


Cys Asp Asp Tyr Lys Arg Leu Val Leu Val Ala Pro Glu Leu Lys Glu 
    210                 215                 220                 


Lys Leu Glu Lys Ala Ala Glu Ala Thr Lys Ile Phe Glu Asp Val Ser 
225                 230                 235                 240 


Leu Asp Glu Ile Phe Ser Ile Lys Phe Tyr Asn Arg Leu Leu Gln Gln 
                245                 250                 255     


Asn Gln Ile Asp Gln Phe Asn Gln Leu Leu Gly Gly Ile Ala Gly Ala 
            260                 265                 270         


Pro Gly Thr Pro Lys Ile Gln Gly Leu Asn Glu Thr Leu Asn Leu Ser 
        275                 280                 285             


Met Gln Gln Asp Lys Thr Leu Glu Gln Lys Leu Lys Ser Val Pro His 
    290                 295                 300                 


Arg Phe Ser Pro Leu Tyr Lys Gln Ile Leu Ser Asp Arg Ser Ser Leu 
305                 310                 315                 320 


Ser Phe Ile Pro Glu Ser Phe Ser Cys Asp Ala Glu Val Leu Leu Ala 
                325                 330                 335     


Val Gln Glu Tyr Leu Asp Asn Leu Lys Thr Glu His Val Ile Glu Asp 
            340                 345                 350         


Leu Lys Glu Val Phe Asn Arg Leu Thr Thr Leu Asp Leu Lys His Ile 
        355                 360                 365             


Tyr Val Asn Ser Thr Lys Val Thr Ala Phe Ser Gln Ala Leu Phe Gly 
    370                 375                 380                 


Asp Trp Asn Leu Cys Arg Glu Gln Leu Arg Val Tyr Lys Met Ser Asn 
385                 390                 395                 400 


Gly Asn Glu Lys Ile Thr Lys Lys Ala Leu Gly Glu Leu Glu Ser Trp 
                405                 410                 415     


Leu Lys Asn Ser Asp Ile Ala Phe Thr Glu Leu Gln Glu Ala Leu Ala 
            420                 425                 430         


Asp Glu Ala Leu Pro Ala Lys Val Asn Leu Lys Val Gln Glu Ala Ile 
        435                 440                 445             


Ser Gly Leu Asn Glu Gln Met Ala Lys Ser Leu Pro Lys Glu Leu Lys 
    450                 455                 460                 


Ile Pro Glu Glu Lys Glu Glu Leu Lys Ala Leu Leu Asp Ala Ile Gln 
465                 470                 475                 480 


Glu Val Tyr His Thr Leu Glu Trp Phe Ile Val Ser Asp Asp Val Glu 
                485                 490                 495     


Thr Asp Thr Asp Phe Tyr Val Pro Leu Lys Glu Thr Leu Gln Ile Ile 
            500                 505                 510         


Gln Pro Ile Ile Pro Leu Tyr Asn Lys Val Arg Asn Phe Ala Thr Gln 
        515                 520                 525             


Lys Pro Tyr Ser Val Glu Lys Phe Lys Leu Asn Phe Ala Asn Pro Thr 
    530                 535                 540                 


Leu Ala Asp Gly Trp Asp Glu Asn Lys Glu Gln Gln Asn Cys Ala Val 
545                 550                 555                 560 


Leu Phe Gln Lys Gly Asn Asn Tyr Tyr Leu Gly Ile Leu Asn Pro Lys 
                565                 570                 575     


Asn Lys Pro Asp Phe Asp Asn Val Asp Thr Glu Lys Gln Gly Asn Cys 
            580                 585                 590         


Tyr Gln Lys Met Val Tyr Lys Gln Phe Pro Asp Phe Ser Lys Met Met 
        595                 600                 605             


Pro Lys Cys Thr Thr Gln Leu Lys Glu Val Lys Gln His Phe Glu Gly 
    610                 615                 620                 


Lys Asp Ser Asp Tyr Ile Leu Asn Asn Lys Asn Phe Ile Lys Pro Leu 
625                 630                 635                 640 


Thr Ile Thr Arg Glu Val Tyr Asp Leu Asn Asn Val Leu Tyr Asp Gly 
                645                 650                 655     


Lys Lys Lys Phe Gln Ile Asp Tyr Leu Arg Lys Thr Lys Asp Glu Asp 
            660                 665                 670         


Gly Tyr Tyr Thr Ala Leu His Thr Trp Ile Asp Phe Ala Lys Lys Phe 
        675                 680                 685             


Val Ala Ser Tyr Lys Ser Thr Ser Ile Tyr Asp Thr Ser Thr Ile Leu 
    690                 695                 700                 


Pro Pro Glu Lys Tyr Glu Lys Leu Asn Glu Phe Tyr Gly Ala Leu Asp 
705                 710                 715                 720 


Asn Leu Phe Tyr Gln Ile Lys Phe Glu Asn Ile Pro Glu Glu Ile Ile 
                725                 730                 735     


Asp Thr Tyr Val Glu Asp Gly Lys Leu Phe Leu Phe Gln Ile Tyr Asn 
            740                 745                 750         


Lys Asp Phe Ala Ala Gly Ala Thr Gly Ala Pro Asn Leu His Thr Ile 
        755                 760                 765             


Tyr Trp Lys Ala Val Phe Asp Pro Glu Asn Val Lys Asp Val Val Val 
    770                 775                 780                 


Lys Leu Asn Gly Gln Ala Glu Leu Phe Tyr Arg Pro Lys Ser Asn Met 
785                 790                 795                 800 


Asp Val Ile Arg His Lys Val Gly Glu Lys Leu Val Asn Arg Thr Leu 
                805                 810                 815     


Lys Asp Gly Ser Ile Leu Thr Asp Glu Leu His Lys Glu Leu Tyr Leu 
            820                 825                 830         


Tyr Ala Asn Gly Ser Leu Lys Lys Gly Leu Ser Glu Asp Ala Lys Ile 
        835                 840                 845             


Ile Leu Asp Lys Asn Leu Ala Val Ile Tyr Asp Val His His Glu Ile 
    850                 855                 860                 


Val Lys Asp Arg Arg Phe Thr Thr Asp Lys Phe Phe Phe His Val Pro 
865                 870                 875                 880 


Leu Thr Leu Asn Tyr Lys Cys Asp Lys Asn Pro Val Lys Phe Asn Ala 
                885                 890                 895     


Glu Val Gln Glu Tyr Leu Lys Glu Asn Pro Asp Thr Tyr Val Ile Gly 
            900                 905                 910         


Ile Asp Arg Gly Glu Arg Asn Leu Ile Tyr Ala Val Val Ile Asp Pro 
        915                 920                 925             


Lys Gly Arg Ile Val Glu Gln Lys Ser Phe Asn Val Ile Asn Gly Phe 
    930                 935                 940                 


Asp Tyr His Gly Lys Leu Asp Gln Arg Glu Lys Glu Arg Val Lys Ala 
945                 950                 955                 960 


Arg Gln Ala Trp Thr Ala Val Gly Lys Ile Lys Glu Leu Lys Gln Gly 
                965                 970                 975     


Tyr Leu Ser Leu Val Val His Glu Ile Ser Lys Met Met Val Arg Tyr 
            980                 985                 990         


Gln Ala Val Val Val Leu Glu Asn  Leu Asn Val Gly Phe  Lys Arg Val 
        995                 1000                 1005             


Arg Ser  Gly Ile Ala Glu Lys  Ala Val Tyr Gln Gln  Phe Glu Lys 
    1010                 1015                 1020             


Met Leu  Ile Asn Lys Leu Asn  Tyr Leu Met Phe Lys  Asp Ala Gly 
    1025                 1030                 1035             


Gly Thr  Glu Pro Gly Ser Val  Leu Asn Ala Tyr Gln  Leu Thr Asp 
    1040                 1045                 1050             


Arg Phe  Glu Ser Phe Ala Lys  Met Gly Leu Gln Thr  Gly Phe Leu 
    1055                 1060                 1065             


Phe Tyr  Ile Pro Ala Ala Phe  Thr Ser Lys Ile Asp  Pro Ala Thr 
    1070                 1075                 1080             


Gly Phe  Val Asp Pro Phe Arg  Trp Gly Ala Ile Lys  Thr Leu Ala 
    1085                 1090                 1095             


Asp Lys  Arg Glu Phe Leu Ser  Gly Phe Glu Ser Leu  Lys Phe Asp 
    1100                 1105                 1110             


Ser Thr  Thr Gly Asn Phe Ile  Leu His Phe Asp Val  Ser Lys Asn 
    1115                 1120                 1125             


Lys Asn  Phe Gln Lys Lys Leu  Glu Gly Phe Val Pro  Asp Trp Asp 
    1130                 1135                 1140             


Ile Ile  Ile Glu Ala Asn Lys  Met Lys Thr Gly Lys  Gly Ala Thr 
    1145                 1150                 1155             


Tyr Ile  Ala Gly Lys Arg Ile  Glu Phe Val Arg Asp  Asn Asn Ser 
    1160                 1165                 1170             


Gln Gly  His Tyr Glu Asp Tyr  Leu Pro Cys Asn Ala  Leu Ala Glu 
    1175                 1180                 1185             


Thr Leu  Arg Gln Cys Asp Ile  Pro Tyr Glu Glu Gly  Lys Asp Ile 
    1190                 1195                 1200             


Leu Pro  Leu Ile Leu Glu Lys  Asn Asp Ser Lys Leu  Leu His Ser 
    1205                 1210                 1215             


Val Phe  Lys Val Val Arg Leu  Thr Leu Gln Met Arg  Asn Ser Asn 
    1220                 1225                 1230             


Ala Glu  Thr Gly Glu Asp Tyr  Ile Ser Ser Pro Val  Glu Asp Val 
    1235                 1240                 1245             


Ser Gly  Ser Cys Phe Asp Ser  Arg Met Glu Asn Glu  Lys Leu Pro 
    1250                 1255                 1260             


Lys Asp  Ala Asp Ala Asn Gly  Ala Tyr His Ile Ala  Leu Lys Gly 
    1265                 1270                 1275             


Met Leu  Ala Leu Glu Arg Leu  Arg Lys Asp Glu Lys  Met Ala Ile 
    1280                 1285                 1290             


Ser Asn  Asn Asp Trp Leu Asn  Tyr Ile Gln Glu Lys  Arg Ala 
    1295                 1300                 1305         


<210>  2
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  2

Met Ala Gly Lys Lys Lys Asp Lys Asp Val Ile Asn Lys Thr Leu Ser 
1               5                   10                  15      


Val Arg Ile Ile Arg Pro Arg Tyr Ser Asp Asp Ile Glu Lys Glu Ile 
            20                  25                  30          


Ser Asp Glu Lys Ala Lys Arg Lys Gln Asp Gly Lys Thr Gly Glu Leu 
        35                  40                  45              


Asp Arg Ala Phe Phe Ser Glu Leu Lys Ser Arg Asn Pro Asp Ile Ile 
    50                  55                  60                  


Thr Asn Asp Glu Leu Phe Pro Leu Phe Thr Glu Ile Gln Lys Asn Leu 
65                  70                  75                  80  


Thr Glu Ile Tyr Asn Lys Ser Ile Ser Leu Leu Tyr Met Lys Leu Ile 
                85                  90                  95      


Val Glu Glu Glu Gly Gly Ser Thr Ala Ser Ala Leu Ser Ala Gly Pro 
            100                 105                 110         


Tyr Lys Glu Cys Lys Ala Arg Phe Asn Ser Tyr Ile Ser Leu Gly Leu 
        115                 120                 125             


Arg Gln Lys Ile Gln Ser Asn Phe Arg Arg Lys Glu Leu Lys Gly Phe 
    130                 135                 140                 


Gln Val Ser Leu Pro Thr Ala Lys Ser Asp Arg Phe Pro Ile Pro Phe 
145                 150                 155                 160 


Cys His Gln Val Glu Asn Gly Lys Gly Gly Phe Lys Val Tyr Glu Thr 
                165                 170                 175     


Gly Asp Asp Phe Ile Phe Glu Val Pro Leu Ile Lys Tyr Thr Ala Thr 
            180                 185                 190         


Asn Lys Lys Ser Thr Ser Gly Lys Asn Tyr Thr Lys Val Gln Leu Asn 
        195                 200                 205             


Asn Pro Pro Val Pro Met Asn Val Pro Leu Leu Leu Ser Thr Met Arg 
    210                 215                 220                 


Arg Arg Gln Thr Lys Lys Gly Met Gln Trp Asn Lys Asp Glu Gly Thr 
225                 230                 235                 240 


Asn Ala Glu Leu Arg Arg Val Met Ser Gly Glu Tyr Lys Val Ser Tyr 
                245                 250                 255     


Ala Glu Ile Ile Arg Arg Thr Arg Phe Gly Lys His Asp Asp Trp Phe 
            260                 265                 270         


Val Asn Phe Ser Ile Lys Phe Lys Asn Lys Thr Asp Glu Leu Asn Gln 
        275                 280                 285             


Asn Val Arg Gly Gly Ile Asp Ile Gly Val Ser Asn Pro Leu Val Cys 
    290                 295                 300                 


Ala Val Thr Asn Gly Leu Asp Arg Tyr Ile Val Ala Asn Asn Asp Ile 
305                 310                 315                 320 


Met Ala Phe Asn Glu Arg Ala Met Ala Arg Arg Arg Thr Leu Leu Arg 
                325                 330                 335     


Lys Asn Arg Phe Lys Arg Ser Gly His Gly Ala Lys Asn Lys Leu Glu 
            340                 345                 350         


Pro Ile Thr Val Leu Thr Glu Lys Asn Glu Arg Phe Arg Lys Ser Ile 
        355                 360                 365             


Leu Gln Arg Trp Ala Arg Glu Val Ala Glu Phe Phe Lys Arg Thr Ser 
    370                 375                 380                 


Ala Ser Val Val Asn Met Glu Asp Leu Ser Gly Ile Thr Glu Arg Glu 
385                 390                 395                 400 


Asp Phe Phe Ser Thr Lys Leu Arg Thr Thr Trp Asn Tyr Arg Leu Met 
                405                 410                 415     


Gln Thr Thr Ile Glu Asn Lys Leu Lys Glu Tyr Gly Ile Ala Val Asn 
            420                 425                 430         


Tyr Ile Ser Pro Lys Tyr Thr Ser Gln Thr Cys His Ser Cys Gly Lys 
        435                 440                 445             


Arg Asn Asp Tyr Phe Thr Phe Ser Tyr Arg Ser Glu Asn Asn Tyr Pro 
    450                 455                 460                 


Pro Phe Glu Cys Lys Glu Cys Asn Lys Val Lys Cys Asn Ala Asp Phe 
465                 470                 475                 480 


Asn Ala Ala Lys Asn Ile Ala Leu Lys Val Val Leu 
                485                 490         


<210>  3
<211>  529
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  3

Met Ala Lys Asn Thr Ile Thr Lys Thr Leu Lys Leu Arg Ile Val Arg 
1               5                   10                  15      


Pro Tyr Asn Ser Ala Glu Val Glu Lys Ile Val Ala Asp Glu Lys Asn 
            20                  25                  30          


Asn Arg Glu Lys Ile Ala Leu Glu Lys Asn Lys Asp Lys Val Lys Glu 
        35                  40                  45              


Ala Cys Ser Lys His Leu Lys Val Ala Ala Tyr Cys Thr Thr Gln Val 
    50                  55                  60                  


Glu Arg Asn Ala Cys Leu Phe Cys Lys Ala Arg Lys Leu Asp Asp Lys 
65                  70                  75                  80  


Phe Tyr Gln Lys Leu Arg Gly Gln Phe Pro Asp Ala Val Phe Trp Gln 
                85                  90                  95      


Glu Ile Ser Glu Ile Phe Arg Gln Leu Gln Lys Gln Ala Ala Glu Ile 
            100                 105                 110         


Tyr Asn Gln Ser Leu Ile Glu Leu Tyr Tyr Glu Ile Phe Ile Lys Gly 
        115                 120                 125             


Lys Gly Ile Ala Asn Ala Ser Ser Val Glu His Tyr Leu Ser Asp Val 
    130                 135                 140                 


Cys Tyr Thr Arg Ala Ala Glu Leu Phe Lys Asn Ala Ala Ile Ala Ser 
145                 150                 155                 160 


Gly Leu Arg Ser Lys Ile Lys Ser Asn Phe Arg Leu Lys Glu Leu Lys 
                165                 170                 175     


Asn Met Lys Ser Gly Leu Pro Thr Thr Lys Ser Asp Asn Phe Pro Ile 
            180                 185                 190         


Pro Leu Val Lys Gln Lys Gly Gly Gln Tyr Thr Gly Phe Glu Ile Ser 
        195                 200                 205             


Asn His Asn Ser Asp Phe Ile Ile Lys Ile Pro Phe Gly Arg Trp Gln 
    210                 215                 220                 


Val Lys Lys Glu Ile Asp Lys Tyr Arg Pro Trp Glu Lys Phe Asp Phe 
225                 230                 235                 240 


Glu Gln Val Gln Lys Ser Pro Lys Pro Ile Ser Leu Leu Leu Ser Thr 
                245                 250                 255     


Gln Arg Arg Lys Arg Asn Lys Gly Trp Ser Lys Asp Glu Gly Thr Glu 
            260                 265                 270         


Ala Glu Ile Lys Lys Val Met Asn Gly Asp Tyr Gln Thr Ser Tyr Ile 
        275                 280                 285             


Glu Val Lys Arg Gly Ser Lys Ile Gly Glu Lys Ser Ala Trp Met Leu 
    290                 295                 300                 


Asn Leu Ser Ile Asp Val Pro Lys Ile Asp Lys Gly Val Asp Pro Ser 
305                 310                 315                 320 


Ile Ile Gly Gly Ile Asp Val Gly Val Lys Ser Pro Leu Val Cys Ala 
                325                 330                 335     


Ile Asn Asn Ala Phe Ser Arg Tyr Ser Ile Ser Asp Asn Asp Leu Phe 
            340                 345                 350         


His Phe Asn Lys Lys Met Phe Ala Arg Arg Arg Ile Leu Leu Lys Lys 
        355                 360                 365             


Asn Arg His Lys Arg Ala Gly His Gly Ala Lys Asn Lys Leu Lys Pro 
    370                 375                 380                 


Ile Thr Ile Leu Thr Glu Lys Ser Glu Arg Phe Arg Lys Lys Leu Ile 
385                 390                 395                 400 


Glu Arg Trp Ala Cys Glu Ile Ala Asp Phe Phe Ile Lys Asn Lys Val 
                405                 410                 415     


Gly Thr Val Gln Met Glu Asn Leu Glu Ser Met Lys Arg Lys Glu Asp 
            420                 425                 430         


Ser Tyr Phe Asn Ile Arg Leu Arg Gly Phe Trp Pro Tyr Ala Glu Met 
        435                 440                 445             


Gln Asn Lys Ile Glu Phe Lys Leu Lys Gln Tyr Gly Ile Glu Ile Arg 
    450                 455                 460                 


Lys Val Ala Pro Asn Asn Thr Ser Lys Thr Cys Ser Lys Cys Gly His 
465                 470                 475                 480 


Leu Asn Asn Tyr Phe Asn Phe Glu Tyr Arg Lys Lys Asn Lys Phe Pro 
                485                 490                 495     


His Phe Lys Cys Glu Lys Cys Asn Phe Lys Glu Asn Ala Asp Tyr Asn 
            500                 505                 510         


Ala Ala Leu Asn Ile Ser Asn Pro Lys Leu Lys Ser Thr Lys Glu Glu 
        515                 520                 525             


Pro 
    


<210>  4
<211>  1297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  4

Met Ala Thr Leu Val Ser Phe Thr Lys Gln Tyr Gln Val Gln Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Gln Ala Asn Ile Asp 
            20                  25                  30          


Ala Lys Gly Phe Ile Asn Asp Asp Leu Lys Arg Asp Glu Asn Tyr Met 
        35                  40                  45              


Lys Val Lys Gly Val Ile Asp Glu Leu His Lys Asn Phe Ile Glu Gln 
    50                  55                  60                  


Thr Leu Val Asn Val Asp Tyr Asp Trp Arg Ser Leu Ala Thr Ala Ile 
65                  70                  75                  80  


Lys Asn Tyr Arg Lys Asp Arg Ser Asp Thr Asn Lys Lys Asn Leu Glu 
                85                  90                  95      


Lys Thr Gln Glu Ala Ala Arg Lys Glu Ile Ile Ala Trp Phe Glu Gly 
            100                 105                 110         


Lys Arg Gly Asn Ser Ala Phe Lys Asn Asn Gln Lys Ser Phe Tyr Gly 
        115                 120                 125             


Lys Leu Phe Lys Lys Glu Leu Phe Ser Glu Ile Leu Arg Ser Asp Asp 
    130                 135                 140                 


Leu Glu Tyr Asp Glu Glu Thr Gln Asp Ala Ile Ala Cys Phe Asp Lys 
145                 150                 155                 160 


Phe Thr Thr Tyr Phe Val Gly Phe His Glu Asn Arg Lys Asn Met Tyr 
                165                 170                 175     


Ser Thr Glu Ala Lys Ser Thr Ser Val Ala Tyr Arg Val Val Asn Glu 
            180                 185                 190         


Asn Phe Ser Lys Phe Leu Ser Asn Cys Glu Ala Phe Ser Val Leu Glu 
        195                 200                 205             


Ala Val Cys Pro Asn Val Leu Val Glu Ala Glu Gln Glu Leu His Leu 
    210                 215                 220                 


His Lys Ala Phe Ser Asp Leu Lys Leu Ser Asp Val Phe Lys Val Glu 
225                 230                 235                 240 


Ala Tyr Asn Lys Tyr Leu Ser Gln Thr Gly Ile Asp Tyr Tyr Asn Gln 
                245                 250                 255     


Ile Ile Gly Gly Ile Ser Ser Ala Glu Gly Val Arg Lys Ile Arg Gly 
            260                 265                 270         


Val Asn Glu Val Val Asn Asn Ala Ile Gln Gln Asn Asp Glu Leu Lys 
        275                 280                 285             


Val Ala Leu Arg Asn Lys Gln Phe Thr Met Val Gln Leu Phe Lys Gln 
    290                 295                 300                 


Ile Leu Ser Asp Arg Ser Thr Leu Ser Phe Val Ser Glu Gln Phe Thr 
305                 310                 315                 320 


Ser Asp Gln Glu Val Ile Thr Val Val Lys Gln Phe Asn Asp Asp Ile 
                325                 330                 335     


Val Asn Asn Lys Val Leu Ala Val Val Lys Thr Leu Phe Glu Asn Phe 
            340                 345                 350         


Asn Ser Tyr Asp Leu Glu Lys Ile Tyr Ile Asn Ser Lys Glu Leu Ala 
        355                 360                 365             


Ser Val Ser Asn Ala Leu Leu Lys Asp Trp Ser Lys Ile Arg Asn Ala 
    370                 375                 380                 


Val Leu Glu Asn Lys Ile Ile Glu Leu Gly Ala Asn Pro Pro Lys Thr 
385                 390                 395                 400 


Lys Ile Ser Ala Val Glu Lys Glu Val Lys Asn Lys Asp Phe Ser Ile 
                405                 410                 415     


Ala Glu Leu Ala Ser Tyr Asn Asp Lys Tyr Leu Asp Lys Glu Gly Asn 
            420                 425                 430         


Asp Lys Glu Ile Cys Ser Ile Ala Asn Val Val Leu Glu Ala Val Gly 
        435                 440                 445             


Ala Leu Glu Ile Met Leu Ala Glu Ser Leu Pro Ala Asp Leu Lys Thr 
    450                 455                 460                 


Leu Glu Asn Lys Asn Lys Val Lys Gly Ile Leu Asp Ala Tyr Glu Asn 
465                 470                 475                 480 


Leu Leu His Leu Leu Asn Tyr Phe Lys Val Ser Ala Val Asn Asp Val 
                485                 490                 495     


Asp Leu Ala Phe Tyr Gly Ala Phe Glu Lys Val Tyr Val Asp Ile Ser 
            500                 505                 510         


Gly Val Met Pro Leu Tyr Asn Lys Val Arg Asn Tyr Ala Thr Lys Lys 
        515                 520                 525             


Pro Tyr Ser Val Glu Lys Phe Lys Leu Asn Phe Ala Met Pro Thr Leu 
    530                 535                 540                 


Ala Asp Gly Trp Asp Lys Asn Lys Glu Arg Asp Asn Gly Ser Ile Ile 
545                 550                 555                 560 


Leu Leu Lys Asp Gly Gln Tyr Tyr Leu Gly Val Met Asn Pro Gln Asn 
                565                 570                 575     


Lys Pro Val Ile Asp Asn Ala Val Cys Asn Asp Ala Lys Gly Tyr Gln 
            580                 585                 590         


Lys Met Val Tyr Lys Met Phe Pro Glu Ile Ser Lys Met Val Thr Lys 
        595                 600                 605             


Cys Ser Thr Gln Leu Asn Ala Val Lys Ala His Phe Glu Asp Asn Thr 
    610                 615                 620                 


Asn Asp Phe Val Leu Asp Asp Thr Asp Lys Phe Ile Ser Asp Leu Thr 
625                 630                 635                 640 


Ile Thr Lys Glu Ile Tyr Asp Leu Asn Asn Val Leu Tyr Asp Gly Lys 
                645                 650                 655     


Lys Lys Phe Gln Ile Asp Tyr Leu Arg Asn Thr Gly Asp Phe Ala Gly 
            660                 665                 670         


Tyr His Lys Ala Leu Glu Thr Trp Ile Asp Phe Val Lys Glu Phe Leu 
        675                 680                 685             


Ser Lys Tyr Arg Ser Thr Ala Ile Tyr Asp Leu Thr Thr Leu Leu Pro 
    690                 695                 700                 


Thr Asn Tyr Tyr Glu Lys Leu Asp Val Phe Tyr Ser Asp Val Asn Asn 
705                 710                 715                 720 


Leu Cys Tyr Lys Ile Asp Tyr Glu Asn Ile Ser Val Glu Gln Val Asn 
                725                 730                 735     


Glu Trp Val Glu Glu Gly Asn Leu Tyr Leu Phe Lys Ile Tyr Asn Lys 
            740                 745                 750         


Asp Phe Ala Thr Gly Ser Thr Gly Lys Pro Asn Leu His Thr Met Tyr 
        755                 760                 765             


Trp Asn Ala Val Phe Ala Glu Glu Asn Leu His Asp Val Val Val Lys 
    770                 775                 780                 


Leu Asn Gly Gly Ala Glu Leu Phe Tyr Arg Pro Lys Ser Asn Met Pro 
785                 790                 795                 800 


Lys Val Glu His Arg Val Gly Glu Lys Leu Val Asn Arg Lys Asn Val 
                805                 810                 815     


Asn Gly Glu Pro Ile Ala Asp Ser Val His Lys Glu Ile Tyr Ala Tyr 
            820                 825                 830         


Ala Asn Gly Lys Ile Ser Lys Ser Glu Leu Ser Glu Asn Ala Gln Glu 
        835                 840                 845             


Glu Leu Pro Leu Ala Ile Ile Lys Asp Val Lys His Asn Ile Thr Lys 
    850                 855                 860                 


Asp Lys Arg Tyr Leu Ser Asp Lys Tyr Phe Phe His Val Pro Ile Thr 
865                 870                 875                 880 


Leu Asn Tyr Lys Ala Asn Gly Asn Pro Ser Ala Phe Asn Thr Lys Val 
                885                 890                 895     


Gln Ala Phe Leu Lys Asn Asn Pro Asp Val Asn Ile Ile Gly Ile Asp 
            900                 905                 910         


Arg Gly Glu Arg Asn Leu Leu Tyr Val Val Val Ile Asp Gln Gln Gly 
        915                 920                 925             


Asn Ile Ile Asp Lys Lys Gln Val Ser Tyr Asn Lys Val Asn Gly Tyr 
    930                 935                 940                 


Asp Tyr Tyr Glu Lys Leu Asn Gln Arg Glu Lys Glu Arg Ile Glu Ala 
945                 950                 955                 960 


Arg Gln Ser Trp Gly Ala Val Gly Lys Ile Lys Glu Leu Lys Glu Gly 
                965                 970                 975     


Tyr Leu Ser Leu Val Val Arg Glu Ile Ala Asp Met Met Val Lys Tyr 
            980                 985                 990         


Asn Ala Ile Val Val Met Glu Asn  Leu Asn Ala Gly Phe  Lys Arg Val 
        995                 1000                 1005             


Arg Gly  Gly Ile Ala Glu Lys  Ala Val Tyr Gln Lys  Phe Glu Lys 
    1010                 1015                 1020             


Met Leu  Ile Asp Lys Leu Asn  Tyr Leu Val Phe Lys  Asp Val Glu 
    1025                 1030                 1035             


Ala Lys  Glu Ala Gly Gly Val  Leu Asn Ala Tyr Gln  Leu Thr Asp 
    1040                 1045                 1050             


Lys Phe  Asp Ser Phe Glu Lys  Met Gly Asn Gln Ser  Gly Phe Leu 
    1055                 1060                 1065             


Phe Tyr  Val Pro Ala Ala Tyr  Thr Ser Lys Ile Asp  Pro Val Thr 
    1070                 1075                 1080             


Gly Phe  Ala Asn Val Phe Ser  Thr Lys His Ile Thr  Asn Thr Glu 
    1085                 1090                 1095             


Ala Lys  Lys Glu Phe Ile Cys  Ser Phe Asn Ser Leu  Arg Tyr Asp 
    1100                 1105                 1110             


Glu Ala  Lys Asp Lys Phe Val  Leu Glu Cys Asp Leu  Asn Lys Phe 
    1115                 1120                 1125             


Lys Ile  Val Ala Asn Ser His  Ile Lys Asn Trp Lys  Phe Ile Ile 
    1130                 1135                 1140             


Gly Gly  Lys Arg Ile Val Tyr  Asn Ser Lys Asn Lys  Thr Tyr Met 
    1145                 1150                 1155             


Glu Lys  Tyr Pro Cys Glu Asp  Leu Lys Ala Thr Leu  Asn Ala Ser 
    1160                 1165                 1170             


Gly Ile  Asp Phe Ser Ser Ser  Glu Ile Ile Asn Leu  Leu Lys Asn 
    1175                 1180                 1185             


Val Pro  Ala Asn Arg Glu Tyr  Gly Lys Leu Phe Asp  Glu Thr Tyr 
    1190                 1195                 1200             


Trp Ala  Ile Met Asn Thr Leu  Gln Met Arg Asn Ser  Asn Ala Leu 
    1205                 1210                 1215             


Thr Gly  Glu Asp Tyr Ile Ile  Ser Ala Val Ala Asp  Asp Asn Glu 
    1220                 1225                 1230             


Lys Val  Phe Asp Ser Arg Thr  Cys Gly Ala Glu Leu  Pro Lys Asp 
    1235                 1240                 1245             


Ala Asp  Ala Asn Gly Ala Tyr  His Ile Ala Leu Lys  Gly Leu Tyr 
    1250                 1255                 1260             


Leu Leu  Gln Arg Ile Asp Ile  Ser Glu Glu Gly Glu  Lys Val Asp 
    1265                 1270                 1275             


Leu Ser  Ile Lys Asn Glu Glu  Trp Phe Lys Phe Val  Gln Gln Lys 
    1280                 1285                 1290             


Glu Tyr  Ala Arg 
    1295         


<210>  5
<211>  1145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  5

Met Cys Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His Lys Lys Tyr 
1               5                   10                  15      


Lys Glu Lys Gly Lys Leu Ile Lys Asn Asn Asp Thr Ala Lys Asp Ile 
            20                  25                  30          


Ile Glu Glu Arg Phe Asn Asp Ile Glu Lys Lys Thr Lys Glu Leu Phe 
        35                  40                  45              


Gln Lys Thr Leu Asp Phe Tyr Val Lys Asn Tyr Glu Lys Cys Lys Glu 
    50                  55                  60                  


Gln Asn Lys Glu Arg Arg Glu Lys Ala Lys Asn Tyr Phe Ser Lys Val 
65                  70                  75                  80  


Lys Ile Leu Val Asp Asn Lys Lys Ile Thr Ile Cys Asn Glu Asn Thr 
                85                  90                  95      


Glu Lys Met Glu Ile Glu Asp Phe Asn Glu Tyr Asp Val Arg Ser Gly 
            100                 105                 110         


Lys Tyr Phe Asn Val Leu Asn Lys Ile Leu Asn Gly Glu Asn Tyr Thr 
        115                 120                 125             


Glu Glu Asp Leu Glu Val Phe Glu Asn Asp Leu Gln Lys Arg Thr Gly 
    130                 135                 140                 


Arg Ile Lys Ser Ile Lys Asn Ser Leu Glu Glu Asn Lys Ala His Phe 
145                 150                 155                 160 


Lys Lys Glu Ser Ile Asn Asn Asn Ile Ile Tyr Asp Arg Val Lys Gly 
                165                 170                 175     


Asn Asn Lys Lys Ser Leu Phe Tyr Glu Tyr Tyr Arg Ile Ser Ser Lys 
            180                 185                 190         


His Gln Glu Tyr Val Asn Asn Ile Phe Glu Ala Phe Asp Lys Leu Tyr 
        195                 200                 205             


Ser Asn Ser His Glu Ala Met Asn Asn Leu Phe Ser Glu Ile Thr Lys 
    210                 215                 220                 


Asp Ser Lys Asp Arg Asn Ile Arg Lys Ile Arg Glu Ala Tyr His Glu 
225                 230                 235                 240 


Ile Leu Asn Lys Asn Lys Thr Glu Phe Gly Glu Glu Leu Tyr Lys Lys 
                245                 250                 255     


Ile Gln Asp Asn Arg Asn Asn Phe Asp Lys Leu Leu Glu Ile Glu Pro 
            260                 265                 270         


Glu Ile Lys Glu Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr Tyr Ile 
        275                 280                 285             


Asp Lys Val Asn Leu Asp Glu Thr Ser Ile Lys His Cys Phe Cys His 
    290                 295                 300                 


Leu Val Glu Ile Glu Val Asn Gln Leu Leu Lys Asn Tyr Val Tyr Ser 
305                 310                 315                 320 


Lys Arg Asn Ile Asn Lys Glu Lys Leu Glu Asn Ile Phe Glu Tyr Cys 
                325                 330                 335     


Lys Leu Lys Asn Leu Ile Lys Asn Lys Leu Val Asn Lys Leu Asn Asn 
            340                 345                 350         


Tyr Ile Arg Asn Cys Gly Lys Tyr Asn Ala Tyr Ile Ser Asn Asn Asp 
        355                 360                 365             


Val Val Val Asn Ser Glu Lys Ile Ser Glu Ile Arg Thr Lys Glu Ala 
    370                 375                 380                 


Phe Leu Arg Ser Ile Ile Gly Val Ser Ser Ser Ala Tyr Phe Ser Leu 
385                 390                 395                 400 


Arg Asn Ile Leu Asn Thr Asp Asn Thr Gln Asp Ile Thr Asn Lys Val 
                405                 410                 415     


Asp Lys Glu Val Asp Lys Leu Tyr Gln Glu Asn Lys Lys Ile Glu Leu 
            420                 425                 430         


Glu Glu Arg Leu Lys Leu Phe Phe Gly Asn Tyr Phe Asp Ile Asn Asn 
        435                 440                 445             


Gln Gln Glu Ile Lys Val Phe Leu Met Asn Ile Asp Lys Ile Ile Ser 
    450                 455                 460                 


Ser Ile Arg His Glu Ile Ile His Phe Lys Met Glu Thr Asn Ala Gln 
465                 470                 475                 480 


Asn Ile Phe Asp Phe Asn Asn Val Asn Leu Gly Asn Thr Ala Lys Asn 
                485                 490                 495     


Ile Phe Ser Asn Glu Ile Asn Glu Glu Lys Ile Lys Phe Lys Ile Phe 
            500                 505                 510         


Lys Gln Leu Asn Ser Ala Asn Val Phe Asp Tyr Leu Ser Asn Lys Asp 
        515                 520                 525             


Ile Thr Glu Tyr Met Asp Lys Val Val Phe Ser Phe Thr Asn Arg Asn 
    530                 535                 540                 


Val Ser Phe Val Pro Ser Phe Thr Lys Ile Tyr Asn Arg Val Gln Asp 
545                 550                 555                 560 


Leu Ala Asn Ser Leu Glu Ile Lys Lys Trp Lys Ile Pro Asp Lys Ser 
                565                 570                 575     


Glu Gly Lys Asp Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly 
            580                 585                 590         


Lys Phe Leu Asp Glu Phe Leu Asn Glu Glu Asn Gly Ile Phe Ile Ser 
        595                 600                 605             


Ile Lys Asp Lys Ile Ile Glu Leu Asn Arg Asn Gln Asn Lys Arg Thr 
    610                 615                 620                 


Gly Phe Tyr Lys Leu Glu Lys Phe Glu Lys Ile Glu Glu Thr Asn Pro 
625                 630                 635                 640 


Lys Lys Tyr Leu Glu Ile Ile Gln Ser Leu Tyr Met Ile Asn Ile Glu 
                645                 650                 655     


Glu Ile Asp Ser Glu Gly Lys Asn Ile Phe Leu Asp Phe Ile Gln Lys 
            660                 665                 670         


Ile Phe Leu Lys Gly Phe Phe Glu Phe Ile Lys Asn Asn Tyr Asn Tyr 
        675                 680                 685             


Leu Leu Glu Leu Lys Lys Ile Gln Asp Lys Lys Asn Ile Phe Asp Ser 
    690                 695                 700                 


Glu Met Ser Glu Tyr Ile Ala Gly Glu Lys Thr Leu Glu Asp Ile Gly 
705                 710                 715                 720 


Glu Ile Asn Glu Ile Ile Gln Asp Ile Lys Ile Thr Glu Ile Asp Lys 
                725                 730                 735     


Ile Leu Asn Gln Thr Asp Lys Ile Asn Cys Phe Tyr Leu Leu Leu Lys 
            740                 745                 750         


Leu Leu Asn Tyr Lys Glu Ile Thr Glu Leu Lys Gly Asn Leu Glu Lys 
        755                 760                 765             


Tyr Gln Ile Leu Ser Lys Thr Asn Val Tyr Glu Lys Glu Leu Met Leu 
    770                 775                 780                 


Leu Asn Ile Val Asn Leu Asp Asn Asn Lys Val Lys Ile Glu Asn Phe 
785                 790                 795                 800 


Lys Ile Leu Ala Glu Glu Ile Gly Lys Phe Ile Glu Lys Ile Asn Ile 
                805                 810                 815     


Glu Glu Ile Asn Lys Asn Lys Lys Ile Lys Thr Phe Glu Glu Leu Arg 
            820                 825                 830         


Asn Phe Glu Lys Gly Glu Asn Thr Gly Glu Tyr Tyr Asn Ile Tyr Ser 
        835                 840                 845             


Asp Asp Lys Asn Ile Lys Asn Ile Arg Asn Leu Tyr Asn Ile Lys Lys 
    850                 855                 860                 


Tyr Gly Met Leu Asp Leu Leu Glu Lys Ile Ser Glu Lys Thr Asn Tyr 
865                 870                 875                 880 


Cys Ile Lys Lys Lys Asp Leu Glu Glu Tyr Ser Glu Leu Arg Lys Gln 
                885                 890                 895     


Leu Glu Asp Glu Lys Thr Asn Phe Tyr Lys Ile Gln Glu Tyr Leu His 
            900                 905                 910         


Ser Lys Tyr Gln Gln Lys Pro Lys Lys Ile Leu Leu Lys Asn Asn Lys 
        915                 920                 925             


Asn Asp Tyr Glu Lys Tyr Lys Lys Ser Ile Glu Asn Ile Glu Lys Tyr 
    930                 935                 940                 


Val His Leu Lys Asn Lys Ile Glu Phe Asn Glu Leu Asn Leu Leu Gln 
945                 950                 955                 960 


Ser Leu Leu Leu Lys Ile Leu His Arg Leu Val Gly Phe Thr Ser Ile 
                965                 970                 975     


Trp Glu Arg Asp Leu Arg Phe Arg Leu Ile Gly Glu Phe Pro Asp Glu 
            980                 985                 990         


Leu Asp Val Glu Asp Ile Phe Asp  His Arg Lys Arg Tyr  Lys Gly Thr 
        995                 1000                 1005             


Gly Lys  Gly Ile Cys Lys Lys  Tyr Asp Arg Phe Ile  Asn Thr His 
    1010                 1015                 1020             


Thr Glu  Tyr Lys Asn Asn Asn  Lys Met Glu Asn Val  Lys Phe Ala 
    1025                 1030                 1035             


Asp Asn  Asn Pro Val Arg Asn  Tyr Ile Ala His Phe  Asn Tyr Leu 
    1040                 1045                 1050             


Pro Asn  Pro Lys Tyr Ser Ile  Leu Lys Met Met Glu  Lys Leu Arg 
    1055                 1060                 1065             


Lys Leu  Leu Asp Tyr Asp Arg  Lys Leu Lys Asn Ala  Val Met Lys 
    1070                 1075                 1080             


Ser Ile  Lys Asp Ile Leu Glu  Glu Tyr Gly Phe Lys  Ala Glu Phe 
    1085                 1090                 1095             


Ile Ile  Asn Ser Asp Lys Glu  Ile Ile Leu Asn Leu  Val Lys Ser 
    1100                 1105                 1110             


Val Glu  Ile Ile His Leu Gly  Lys Glu Asp Leu Lys  Ser Arg Arg 
    1115                 1120                 1125             


Asn Ser  Glu Asp Leu Cys Lys  Leu Val Lys Ala Met  Leu Glu Tyr 
    1130                 1135                 1140             


Ser Lys  
    1145 


<210>  6
<211>  1271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  6

Met Glu Asp Lys Gln Phe Leu Glu Arg Tyr Lys Glu Phe Ile Gly Leu 
1               5                   10                  15      


Asn Ser Leu Ser Lys Thr Leu Arg Asn Ser Leu Ile Pro Val Gly Ser 
            20                  25                  30          


Thr Leu Lys His Ile Gln Glu Tyr Gly Ile Leu Glu Glu Asp Ser Leu 
        35                  40                  45              


Arg Ala Gln Lys Arg Glu Glu Leu Lys Gly Ile Met Asp Asp Tyr Tyr 
    50                  55                  60                  


Arg Asn Tyr Ile Glu Met His Leu Arg Asp Val His Asp Ile Asp Trp 
65                  70                  75                  80  


Asn Glu Leu Phe Glu Ala Leu Thr Glu Val Lys Lys Asn Gln Thr Asp 
                85                  90                  95      


Asp Ala Lys Lys Arg Leu Glu Lys Ile Gln Glu Lys Lys Arg Lys Glu 
            100                 105                 110         


Ile Tyr Gln Tyr Leu Ser Asp Asp Ala Val Phe Ser Glu Met Phe Lys 
        115                 120                 125             


Glu Lys Met Ile Ser Gly Ile Leu Pro Asp Phe Ile Arg Cys Asn Glu 
    130                 135                 140                 


Gly Tyr Ser Glu Glu Glu Lys Glu Glu Lys Leu Lys Thr Val Ala Leu 
145                 150                 155                 160 


Phe His Arg Phe Thr Ser Ser Phe Asn Asp Phe Phe Leu Asn Arg Lys 
                165                 170                 175     


Asn Val Phe Thr Lys Glu Ala Ile Val Thr Ala Ile Gly Tyr Arg Val 
            180                 185                 190         


Val His Glu Asn Ala Glu Ile Phe Leu Glu Asn Met Val Ala Phe Gln 
        195                 200                 205             


Asn Ile Gln Lys Ser Ala Glu Ser Gln Ile Ser Ile Ile Glu Arg Lys 
    210                 215                 220                 


Asn Glu His Tyr Phe Met Glu Trp Lys Leu Ser His Ile Phe Thr Ala 
225                 230                 235                 240 


Asp Tyr Tyr Met Met Leu Met Thr Gln Lys Ala Ile Glu His Tyr Asn 
                245                 250                 255     


Glu Met Cys Gly Val Val Asn Gln Gln Met Arg Glu Tyr Cys Gln Lys 
            260                 265                 270         


Glu Lys Lys Asn Trp Asn Leu Tyr Arg Met Lys Arg Leu His Lys Gln 
        275                 280                 285             


Ile Leu Ser Asn Ala Ser Thr Ser Phe Lys Ile Pro Glu Lys Tyr Glu 
    290                 295                 300                 


Asn Asp Ala Glu Val Tyr Glu Ser Val Asn Ser Phe Leu Gln Asn Val 
305                 310                 315                 320 


Met Glu Lys Thr Val Met Glu Arg Ile Ala Val Leu Lys Asn Ser Thr 
                325                 330                 335     


Asp Asn Phe Asp Leu Ser Lys Ile Tyr Ile Thr Ala Pro Tyr Tyr Glu 
            340                 345                 350         


Lys Ile Ser Asn Tyr Leu Cys Gly Ser Trp Asn Thr Ile Thr Asp Cys 
        355                 360                 365             


Leu Thr His Tyr Tyr Glu Gln Gln Ile Ala Gly Lys Gly Ala Arg Lys 
    370                 375                 380                 


Asp Gln Lys Val Lys Ala Ala Val Lys Ala Asp Lys Trp Lys Ser Leu 
385                 390                 395                 400 


Ser Glu Ile Glu Gln Leu Leu Lys Glu Tyr Ala Arg Ala Glu Glu Val 
                405                 410                 415     


Lys Arg Lys Pro Glu Glu Tyr Ile Ala Glu Ile Glu Asn Ile Val Ser 
            420                 425                 430         


Leu Lys Glu Ala His Leu Leu Glu Tyr His Pro Glu Val Asn Leu Ile 
        435                 440                 445             


Glu Asn Glu Lys Tyr Ala Thr Glu Ile Lys Asp Val Leu Asp Asn Tyr 
    450                 455                 460                 


Met Glu Leu Phe His Trp Met Lys Trp Phe Tyr Ile Glu Glu Ala Val 
465                 470                 475                 480 


Glu Lys Glu Val Asn Phe Tyr Gly Glu Leu Asp Asp Leu Tyr Glu Glu 
                485                 490                 495     


Ile Lys Asp Ile Val Pro Leu Tyr Asn Lys Val Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Asp Thr Lys Ile Lys Leu Asn Phe Gly Thr Pro 
        515                 520                 525             


Thr Leu Ala Asn Gly Trp Ser Lys Ser Lys Glu Tyr Asp Tyr Asn Ala 
    530                 535                 540                 


Ile Leu Leu Gln Lys Asp Gly Lys Tyr Tyr Met Gly Ile Phe Asn Pro 
545                 550                 555                 560 


Ile Gln Lys Pro Glu Lys Glu Ile Ile Glu Gly His Ser Gln Pro Leu 
                565                 570                 575     


Glu Gly Asn Glu Tyr Lys Lys Met Val Tyr Tyr Tyr Leu Pro Ser Ala 
            580                 585                 590         


Asn Lys Met Leu Pro Lys Val Leu Leu Ser Lys Lys Gly Met Glu Ile 
        595                 600                 605             


Tyr Gln Pro Ser Glu Tyr Ile Ile Asn Gly Tyr Lys Glu Arg Arg His 
    610                 615                 620                 


Ile Lys Ser Glu Glu Lys Phe Asp Leu Gln Phe Cys His Asp Leu Ile 
625                 630                 635                 640 


Asp Tyr Phe Lys Ser Gly Ile Glu Arg Asn Ser Asp Trp Lys Val Phe 
                645                 650                 655     


Gly Phe Asp Phe Ser Asp Thr Asp Thr Tyr Gln Asp Ile Ser Gly Phe 
            660                 665                 670         


Tyr Arg Glu Val Glu Asp Gln Gly Tyr Lys Ile Asp Trp Thr Tyr Ile 
        675                 680                 685             


Lys Glu Ala Asp Ile Asp Arg Leu Asn Glu Glu Gly Lys Leu Tyr Leu 
    690                 695                 700                 


Phe Gln Ile Tyr Asn Lys Asp Phe Ser Glu Lys Ser Thr Gly Arg Glu 
705                 710                 715                 720 


Asn Leu His Thr Met Tyr Leu Lys Asn Leu Phe Ser Glu Glu Asn Val 
                725                 730                 735     


Arg Glu Gln Val Leu Lys Leu Asn Gly Glu Ala Glu Ile Phe Phe Arg 
            740                 745                 750         


Lys Ser Ser Val Lys Lys Pro Ile Ile His Lys Lys Gly Thr Met Leu 
        755                 760                 765             


Val Asn Arg Thr Tyr Met Glu Glu Val Asn Gly Asn Ser Val Arg Arg 
    770                 775                 780                 


Asn Ile Pro Glu Lys Glu Tyr Gln Glu Ile Tyr Asn Tyr Lys Asn His 
785                 790                 795                 800 


Arg Leu Lys Gly Glu Leu Ser Thr Glu Ala Lys Lys Tyr Leu Glu Lys 
                805                 810                 815     


Ala Val Cys His Glu Thr Lys Lys Asp Ile Val Lys Asp Tyr Arg Tyr 
            820                 825                 830         


Ser Val Asp Lys Phe Phe Ile His Leu Pro Ile Thr Ile Asn Tyr Arg 
        835                 840                 845             


Ala Ser Gly Lys Glu Thr Leu Asn Ser Val Ala Gln Arg Tyr Ile Ala 
    850                 855                 860                 


His Gln Asn Asp Met His Val Ile Gly Ile Asp Arg Gly Glu Arg Asn 
865                 870                 875                 880 


Leu Ile Tyr Val Ser Val Ile Asn Met Gln Gly Glu Ile Lys Glu Gln 
                885                 890                 895     


Lys Ser Phe Asn Ile Ile Asn Glu Phe Asn Tyr Lys Glu Lys Leu Lys 
            900                 905                 910         


Glu Arg Glu Gln Ser Arg Gly Ala Ala Arg Arg Asn Trp Lys Glu Ile 
        915                 920                 925             


Gly Gln Ile Lys Asp Leu Lys Glu Gly Tyr Leu Ser Gly Val Ile His 
    930                 935                 940                 


Glu Ile Ala Lys Met Met Ile Lys Tyr His Ala Ile Ile Ala Met Glu 
945                 950                 955                 960 


Asp Leu Asn Tyr Gly Phe Lys Arg Gly Arg Phe Lys Val Glu Arg Gln 
                965                 970                 975     


Val Tyr Gln Lys Phe Glu Asn Met Leu Ile Gln Lys Leu Asn Tyr Leu 
            980                 985                 990         


Val Phe Lys Asp Arg Pro Ala Asp  Glu Asp Gly Gly Val  Leu Arg Gly 
        995                 1000                 1005             


Tyr Gln  Leu Ala Tyr Ile Pro  Asp Ser Val Lys Lys  Met Gly Arg 
    1010                 1015                 1020             


Gln Cys  Gly Met Ile Phe Tyr  Val Pro Ala Ala Phe  Thr Ser Lys 
    1025                 1030                 1035             


Ile Asp  Pro Thr Thr Gly Phe  Val Asp Ile Phe Lys  His Lys Val 
    1040                 1045                 1050             


Tyr Thr  Thr Glu Gln Ala Lys  Arg Glu Phe Ile Leu  Ser Phe Asp 
    1055                 1060                 1065             


Glu Ile  Cys Tyr Asp Val Glu  Arg Gln Leu Phe Arg  Phe Thr Phe 
    1070                 1075                 1080             


Asp Tyr  Ala Asn Phe Val Thr  Gln Asn Val Thr Leu  Ala Arg Asn 
    1085                 1090                 1095             


Asn Trp  Thr Ile Tyr Thr Asn  Gly Thr Arg Ala Gln  Lys Glu Phe 
    1100                 1105                 1110             


Gly Asn  Gly Arg Met Arg Asp  Lys Glu Asp Tyr Asn  Pro Lys Asp 
    1115                 1120                 1125             


Lys Met  Val Glu Leu Leu Glu  Ser Glu Gly Ile Glu  Phe Lys Ser 
    1130                 1135                 1140             


Gly Lys  Asn Leu Leu Pro Ala  Leu Lys Lys Val Ser  Asn Ala Lys 
    1145                 1150                 1155             


Val Phe  Glu Glu Leu Gln Lys  Ile Val Arg Phe Thr  Val Gln Leu 
    1160                 1165                 1170             


Arg Asn  Ser Lys Ser Glu Glu  Asn Asp Val Asp Tyr  Asp His Val 
    1175                 1180                 1185             


Ile Ser  Pro Val Leu Asn Glu  Glu Gly Asn Phe Phe  Asp Ser Ser 
    1190                 1195                 1200             


Lys Tyr  Lys Asn Lys Glu Glu  Lys Lys Glu Ser Leu  Leu Pro Val 
    1205                 1210                 1215             


Asp Ala  Asp Ala Asn Gly Ala  Tyr Cys Ile Ala Leu  Lys Gly Leu 
    1220                 1225                 1230             


Tyr Ile  Met Gln Ala Ile Gln  Lys Asn Trp Ser Glu  Glu Lys Ala 
    1235                 1240                 1245             


Leu Ser  Pro Asp Val Leu Arg  Leu Asn Asn Asn Asp  Trp Phe Asp 
    1250                 1255                 1260             


Tyr Ile  Gln Asn Lys Arg Tyr  Arg 
    1265                 1270     


<210>  7
<211>  1229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  7

Met Glu Glu Lys Lys Met Ser Lys Ile Glu Lys Phe Ile Gly Lys Tyr 
1               5                   10                  15      


Lys Ile Ser Lys Thr Leu Arg Phe Arg Ala Val Pro Val Gly Lys Thr 
            20                  25                  30          


Gln Asp Asn Ile Glu Lys Lys Gly Ile Leu Glu Lys Asp Lys Lys Arg 
        35                  40                  45              


Ser Glu Asp Tyr Glu Lys Val Lys Ala Tyr Leu Asp Ser Leu His Arg 
    50                  55                  60                  


Asp Phe Ile Glu Asn Thr Leu Lys Lys Val Lys Leu Asn Glu Leu Asn 
65                  70                  75                  80  


Glu Tyr Ala Cys Leu Phe Phe Ser Gly Thr Lys Asp Asp Gly Asp Lys 
                85                  90                  95      


Lys Lys Met Glu Lys Leu Glu Glu Lys Met Arg Lys Thr Ile Ser Asn 
            100                 105                 110         


Glu Phe Cys Asn Asp Glu Met Tyr Lys Lys Ile Phe Ser Glu Lys Ile 
        115                 120                 125             


Leu Ser Glu Asn Asn Glu Glu Asp Val Ser Asp Ile Val Ser Ser Tyr 
    130                 135                 140                 


Lys Gly Phe Phe Thr Ser Leu Asn Gly Tyr Val Asn Asn Arg Lys Asn 
145                 150                 155                 160 


Leu Tyr Val Ser Asp Ala Lys Pro Thr Ser Ile Ala Tyr Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Pro Lys Phe Leu Arg Asn Val Glu Cys Tyr Lys Lys 
            180                 185                 190         


Val Val Gln Val Ile Pro Lys Glu Gln Ile Glu Tyr Met Ser Asn Asn 
        195                 200                 205             


Leu Asn Leu Ser Pro Tyr Arg Ile Glu Asp Cys Phe Asn Ile Asp Phe 
    210                 215                 220                 


Phe Glu Phe Cys Leu Ser Gln Gly Gly Ile Asp Leu Tyr Asn Thr Phe 
225                 230                 235                 240 


Ile Gly Gly Tyr Ser Lys Lys Asp Gly Thr Lys Val Gln Gly Ile Asn 
                245                 250                 255     


Glu Ile Val Asn Leu Tyr Asn Gln Lys Asn Lys Lys Asp Lys Glu Lys 
            260                 265                 270         


Tyr Lys Leu Pro Gln Phe Thr Pro Leu Phe Lys Gln Ile Leu Ser Asp 
        275                 280                 285             


Arg Asp Thr Lys Ser Phe Ser Ile Glu Lys Leu Glu Asn Ile Tyr Glu 
    290                 295                 300                 


Val Val Glu Leu Val Lys Lys Ser Tyr Ser Asp Glu Met Phe Asp Asp 
305                 310                 315                 320 


Ile Glu Thr Val Phe Ser Asn Leu Asn Tyr Tyr Asp Ala Ser Gly Ile 
                325                 330                 335     


Tyr Val Lys Asn Gly Pro Ala Ile Thr His Ile Ser Met Asn Leu Thr 
            340                 345                 350         


Lys Asp Trp Ala Thr Ile Arg Asn Asn Trp Asn Tyr Glu Tyr Asp Glu 
        355                 360                 365             


Lys His Ser Thr Lys Lys Asn Lys Asn Ile Glu Lys Tyr Glu Asp Thr 
    370                 375                 380                 


Arg Asn Thr Met Tyr Lys Lys Ile Asp Ser Phe Thr Leu Glu Tyr Ile 
385                 390                 395                 400 


Ser Arg Leu Val Gly Lys Asp Ile Asp Glu Leu Val Lys Tyr Phe Glu 
                405                 410                 415     


Asn Glu Val Ala Asn Phe Val Met Asp Ile Lys Lys Thr Tyr Ser Lys 
            420                 425                 430         


Leu Thr Pro Leu Phe Asp Arg Cys Gln Lys Glu Asn Phe Asp Ile Ser 
        435                 440                 445             


Glu Asp Glu Val Asn Asp Ile Lys Gly Tyr Leu Asp Asn Val Lys Leu 
    450                 455                 460                 


Leu Glu Ser Phe Met Lys Ser Phe Thr Ile Asn Gly Lys Glu Asn Asn 
465                 470                 475                 480 


Ile Asp Tyr Val Phe Tyr Gly Lys Phe Thr Asp Asp Tyr Asp Lys Leu 
                485                 490                 495     


His Glu Phe Asp His Ile Tyr Asn Lys Val Arg Asn Tyr Ile Thr Thr 
            500                 505                 510         


Ser Arg Lys Pro Tyr Lys Leu Asp Lys Tyr Lys Leu Tyr Phe Asp Asn 
        515                 520                 525             


Pro Gln Leu Leu Gly Gly Trp Asp Ile Asn Lys Glu Lys Asp Tyr Arg 
    530                 535                 540                 


Thr Val Met Leu Thr Lys Asp Gly Lys Tyr Tyr Phe Ala Ile Ile Asp 
545                 550                 555                 560 


Lys Gly Glu His Pro Phe Asp Asn Ile Pro Lys Asp Tyr Phe Asp Asn 
                565                 570                 575     


Asn Gly Tyr Tyr Lys Lys Ile Ile Tyr Arg Gln Ile Pro Asn Ala Ala 
            580                 585                 590         


Lys Tyr Leu Ser Ser Lys Gln Ile Val Pro Gln Asn Pro Pro Glu Glu 
        595                 600                 605             


Val Lys Arg Ile Leu Asp Lys Lys Lys Ala Asp Ser Lys Ser Leu Thr 
    610                 615                 620                 


Glu Glu Glu Lys Asn Ile Phe Ile Asp Tyr Ile Lys Ser Asp Phe Leu 
625                 630                 635                 640 


Lys Asn Tyr Lys Leu Leu Phe Asp Lys Asn Asn Asn Pro Tyr Phe Asn 
                645                 650                 655     


Phe Ala Phe Arg Glu Ser Ser Thr Tyr Glu Ser Leu Asn Glu Phe Phe 
            660                 665                 670         


Glu Asp Val Glu Arg Gln Ala Tyr Ser Val Arg Tyr Glu Asn Leu Pro 
        675                 680                 685             


Ala Asp Tyr Ile Asp Asn Leu Val Asn Glu Gly Lys Ile Tyr Leu Phe 
    690                 695                 700                 


Glu Ile Tyr Ser Lys Asp Phe Ser Glu Tyr Ser Lys Gly Thr Asn Asn 
705                 710                 715                 720 


Leu His Thr Met Tyr Phe Lys Ala Leu Phe Asp Asn Asp Asn Leu Lys 
                725                 730                 735     


Asn Thr Val Phe Lys Leu Ser Gly Asn Ala Glu Leu Phe Ile Arg Pro 
            740                 745                 750         


Ala Ser Ile Lys Lys Asp Glu Leu Val Ile His Pro Lys Asn Gln Leu 
        755                 760                 765             


Leu Gln Asn Lys Asn Pro Leu Asn Pro Lys Lys Gln Ser Ile Phe Asp 
    770                 775                 780                 


Tyr Asp Leu Val Lys Asp Lys Arg Phe Phe Glu Asn Gln Tyr Met Leu 
785                 790                 795                 800 


His Ile Ser Ile Glu Ile Asn Lys Asn Glu Arg Asp Ala Lys Lys Ile 
                805                 810                 815     


Lys Asn Ile Asn Glu Met Val Arg Lys Glu Leu Lys Asp Ser Asp Asp 
            820                 825                 830         


Asn Tyr Ile Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Val 
        835                 840                 845             


Cys Val Ile Asn Ser Ala Gly Lys Ile Val Glu Gln Met Ser Leu Asn 
    850                 855                 860                 


Glu Ile Ile Asn Glu Tyr Asn Gly Ile Lys His Thr Val Asp Tyr Gln 
865                 870                 875                 880 


Gly Leu Leu Asp Lys Cys Glu Lys Glu Arg Asn Ala Gln Arg Gln Ser 
                885                 890                 895     


Trp Lys Ser Ile Glu Asn Ile Lys Glu Leu Lys Asp Gly Tyr Ile Ser 
            900                 905                 910         


Gln Val Val His Lys Leu Cys Gln Leu Val Glu Lys Tyr Asp Ala Ile 
        915                 920                 925             


Ile Ala Met Glu Asn Leu Asn Gly Gly Phe Lys Arg Gly Arg Thr Lys 
    930                 935                 940                 


Phe Glu Lys Gln Val Tyr Gln Lys Phe Glu Asn Lys Leu Ile Asn Lys 
945                 950                 955                 960 


Met Glu Tyr Met Ala Asp Lys Lys Arg Lys Thr Thr Glu Asn Gly Gly 
                965                 970                 975     


Ile Leu Arg Gly Tyr Gln Leu Thr Asn Gly Cys Ile Asn Asn Ser Tyr 
            980                 985                 990         


Gln Asn Gly Phe Ile Phe Tyr Val  Pro Ala Trp Leu Thr  Ser Lys Ile 
        995                 1000                 1005             


Asp Pro  Thr Thr Gly Phe Val  Asp Leu Leu Lys Pro  Lys Tyr Thr 
    1010                 1015                 1020             


Asn Val  Glu Glu Ala His Leu  Trp Ile Asn Lys Phe  Asn Ser Ile 
    1025                 1030                 1035             


Thr Tyr  Asp Lys Lys Leu Asp  Met Phe Ala Phe Asn  Ile Asn Tyr 
    1040                 1045                 1050             


Ser Gln  Phe Pro Arg Ala Asp  Ile Asp Tyr Arg Lys  Ile Trp Thr 
    1055                 1060                 1065             


Phe Tyr  Thr Asn Gly Tyr Arg  Ile Glu Thr Phe Arg  Asn Ser Glu 
    1070                 1075                 1080             


Lys Asn  Asn Glu Phe Asp Trp  Lys Glu Val His Leu  Thr Ser Val 
    1085                 1090                 1095             


Ile Lys  Lys Leu Leu Glu Glu  Tyr Gln Ile Asn Tyr  Ile Ser Gly 
    1100                 1105                 1110             


Lys Asn  Ile Ile Asp Asp Leu  Ile Gln Ile Lys Asp  Lys Pro Phe 
    1115                 1120                 1125             


Trp Asn  Ser Phe Ile Lys Tyr  Ile Arg Leu Thr Leu  Gln Met Arg 
    1130                 1135                 1140             


Asn Ser  Ile Thr Gly Arg Thr  Asp Val Asp Tyr Ile  Ile Ser Pro 
    1145                 1150                 1155             


Val Ile  Asn Asn Glu Gly Thr  Phe Tyr Asp Ser Arg  Lys Asp Leu 
    1160                 1165                 1170             


Asp Glu  Ile Thr Leu Pro Gln  Asp Ala Asp Ala Asn  Gly Ala Tyr 
    1175                 1180                 1185             


Asn Ile  Ala Arg Lys Ala Leu  Trp Ile Ile Glu Lys  Leu Lys Glu 
    1190                 1195                 1200             


Ser Pro  Asp Glu Glu Leu Asn  Lys Val Lys Leu Ala  Ile Thr Gln 
    1205                 1210                 1215             


Arg Glu  Trp Leu Glu Tyr Ala  Gln Ile Asn Ile 
    1220                 1225                 


<210>  8
<211>  835
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  8

Met Glu Lys Ile Lys Lys Pro Ser Asn Arg Asn Ser Ile Pro Ser Ile 
1               5                   10                  15      


Ile Ile Ser Asp Tyr Asp Ala Asn Lys Ile Lys Glu Ile Lys Val Lys 
            20                  25                  30          


Tyr Leu Lys Leu Ala Arg Leu Asp Lys Ile Thr Ile Gln Asp Met Glu 
        35                  40                  45              


Ile Val Asp Asn Ile Val Glu Phe Lys Lys Ile Leu Leu Asn Gly Val 
    50                  55                  60                  


Glu His Thr Ile Ile Asp Asn Gln Lys Ile Glu Phe Asp Asn Tyr Glu 
65                  70                  75                  80  


Ile Thr Gly Cys Ile Lys Pro Ser Asn Lys Arg Arg Asp Gly Arg Ile 
                85                  90                  95      


Ser Gln Ala Lys Tyr Val Val Thr Ile Thr Asp Lys Tyr Leu Arg Glu 
            100                 105                 110         


Asn Glu Lys Glu Lys Arg Phe Lys Ser Thr Glu Arg Glu Leu Pro Asn 
        115                 120                 125             


Asn Thr Leu Leu Ser Arg Tyr Lys Gln Ile Ser Gly Phe Asp Thr Leu 
    130                 135                 140                 


Thr Ser Lys Asp Ile Tyr Lys Ile Lys Arg Tyr Ile Asp Phe Lys Asn 
145                 150                 155                 160 


Glu Met Leu Phe Tyr Phe Gln Phe Ile Glu Glu Phe Phe Asn Pro Leu 
                165                 170                 175     


Leu Pro Lys Gly Lys Asn Phe Tyr Asp Leu Asn Ile Glu Gln Asn Lys 
            180                 185                 190         


Asp Lys Val Ala Lys Phe Ile Val Tyr Arg Leu Asn Asp Asp Phe Lys 
        195                 200                 205             


Asn Lys Ser Leu Asn Ser Tyr Ile Thr Asp Thr Cys Met Ile Ile Asn 
    210                 215                 220                 


Asp Phe Lys Lys Ile Gln Lys Ile Leu Ser Asp Phe Arg His Ala Leu 
225                 230                 235                 240 


Ala His Phe Asp Phe Asp Phe Ile Gln Lys Phe Phe Asp Asp Gln Leu 
                245                 250                 255     


Asp Lys Asn Lys Phe Asp Ile Asn Thr Ile Ser Leu Ile Glu Thr Leu 
            260                 265                 270         


Leu Asp Gln Lys Glu Glu Lys Asn Tyr Gln Glu Lys Asn Asn Tyr Ile 
        275                 280                 285             


Asp Asp Asn Asp Ile Leu Thr Ile Phe Asp Glu Lys Gly Ser Lys Phe 
    290                 295                 300                 


Ser Lys Leu His Asn Phe Tyr Thr Lys Ile Ser Gln Lys Lys Pro Ala 
305                 310                 315                 320 


Phe Asn Lys Leu Ile Asn Ser Phe Leu Ser Gln Asp Gly Val Pro Asn 
                325                 330                 335     


Glu Glu Phe Lys Ser Tyr Leu Val Thr Lys Lys Leu Asp Phe Phe Glu 
            340                 345                 350         


Asp Ile His Ser Asn Lys Glu Tyr Lys Lys Ile Tyr Ile Gln His Lys 
        355                 360                 365             


Asn Leu Val Ile Lys Lys Gln Lys Glu Glu Ser Gln Glu Lys Pro Asp 
    370                 375                 380                 


Gly Gln Lys Leu Lys Asn Tyr Asn Asp Glu Leu Gln Lys Leu Lys Asp 
385                 390                 395                 400 


Glu Met Asn Thr Ile Thr Lys Gln Asn Ser Leu Asn Arg Leu Glu Val 
                405                 410                 415     


Lys Leu Arg Leu Ala Phe Gly Phe Ile Ala Asn Glu Tyr Asn Tyr Asn 
            420                 425                 430         


Phe Lys Asn Phe Asn Asp Glu Phe Thr Asn Asp Val Lys Asn Glu Gln 
        435                 440                 445             


Lys Ile Lys Ala Phe Lys Asn Ser Ser Asn Glu Lys Leu Lys Glu Tyr 
    450                 455                 460                 


Phe Glu Ser Thr Phe Ile Glu Lys Arg Phe Phe His Phe Ser Val Asn 
465                 470                 475                 480 


Phe Phe Asn Lys Lys Thr Lys Lys Glu Glu Thr Lys Gln Lys Asn Ile 
                485                 490                 495     


Phe Asn Ser Ile Glu Asn Glu Thr Leu Glu Glu Leu Val Lys Glu Ser 
            500                 505                 510         


Pro Leu Leu Gln Ile Ile Thr Leu Leu Tyr Leu Phe Ile Pro Arg Glu 
        515                 520                 525             


Leu Gln Gly Glu Phe Val Gly Phe Ile Leu Lys Ile Tyr His His Thr 
    530                 535                 540                 


Lys Asn Ile Thr Ser Asp Thr Lys Glu Asp Glu Ile Ser Ile Glu Asp 
545                 550                 555                 560 


Ala Gln Asn Ser Phe Ser Leu Lys Phe Lys Ile Leu Ala Lys Asn Leu 
                565                 570                 575     


Arg Gly Leu Gln Leu Phe His Tyr Ser Leu Ser His Asn Thr Leu Tyr 
            580                 585                 590         


Asn Asn Lys Gln Cys Phe Phe Tyr Glu Lys Gly Asn Arg Trp Gln Ser 
        595                 600                 605             


Val Tyr Lys Ser Phe Gln Ile Ser His Asn Gln Asp Glu Phe Asp Ile 
    610                 615                 620                 


His Leu Val Ile Pro Val Ile Lys Tyr Tyr Ile Asn Leu Asn Lys Leu 
625                 630                 635                 640 


Met Gly Asp Phe Glu Ile Tyr Ala Leu Leu Lys Tyr Ala Asp Lys Asn 
                645                 650                 655     


Ser Ile Thr Val Lys Leu Ser Asp Ile Thr Ser Arg Asp Asp Leu Lys 
            660                 665                 670         


Tyr Asn Gly His Tyr Asn Phe Ala Thr Leu Leu Phe Lys Thr Phe Gly 
        675                 680                 685             


Ile Asp Thr Asn Tyr Lys Gln Asn Lys Val Ser Ile Gln Asn Ile Lys 
    690                 695                 700                 


Lys Thr Arg Asn Asn Leu Ala His Gln Asn Ile Glu Asn Met Leu Lys 
705                 710                 715                 720 


Ala Phe Glu Asn Ser Glu Ile Phe Ala Gln Arg Glu Glu Ile Val Asn 
                725                 730                 735     


Tyr Leu Gln Thr Glu His Arg Met Gln Glu Val Leu His Tyr Asn Pro 
            740                 745                 750         


Ile Asn Asp Phe Thr Met Lys Thr Val Gln Tyr Leu Lys Ser Leu Ser 
        755                 760                 765             


Val His Ser Gln Lys Glu Gly Lys Ile Ala Asp Ile His Lys Lys Glu 
    770                 775                 780                 


Ser Leu Val Pro Asn Asp Tyr Tyr Leu Ile Tyr Lys Leu Lys Ala Ile 
785                 790                 795                 800 


Glu Leu Leu Lys Gln Lys Val Ile Glu Val Ile Gly Glu Ser Glu Asp 
                805                 810                 815     


Glu Lys Lys Ile Lys Asn Ala Ile Ala Lys Glu Glu Gln Ile Lys Lys 
            820                 825                 830         


Gly Asn Asn 
        835 


<210>  9
<211>  1367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  9

Met Glu Lys Ser Leu Asn Asp Phe Ile Gly Leu Tyr Ser Val Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Glu Leu Lys Pro Val Ser Glu Thr Leu Glu Asn Ile 
            20                  25                  30          


Lys Lys Phe His Phe Leu Glu Glu Asp Lys Lys Lys Ala Asn Asp Tyr 
        35                  40                  45              


Lys Asp Val Lys Lys Ile Ile Asp Asn Tyr His Lys Tyr Phe Ile Asp 
    50                  55                  60                  


Asp Val Leu Lys Asn Ala Ser Phe Asn Trp Lys Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Ile Arg Glu Tyr Asn Lys Asn Lys Ser Asp Asp Ser Ala Leu Val Ala 
                85                  90                  95      


Glu Gln Lys Lys Leu Gly Asp Ala Ile Leu Lys Leu Phe Thr Ser Asp 
            100                 105                 110         


Lys Arg Tyr Lys Ala Leu Thr Ala Ala Thr Pro Lys Glu Leu Phe Glu 
        115                 120                 125             


Ser Ile Leu Pro Asp Trp Phe Gly Glu Gln Cys Asn Gln Asp Leu Asn 
    130                 135                 140                 


Lys Ala Ala Leu Lys Thr Phe Gln Lys Phe Thr Ser Tyr Phe Thr Gly 
145                 150                 155                 160 


Phe Gln Glu Asn Arg Lys Asn Val Tyr Ser Ala Glu Ala Ile Pro Thr 
                165                 170                 175     


Ala Val Pro Tyr Arg Ile Val Asn Asp Asn Phe Pro Lys Phe Leu Gln 
            180                 185                 190         


Asn Val Leu Ile Phe Lys Thr Ile Gln Glu Lys Cys Pro Gln Ile Ile 
        195                 200                 205             


Asp Glu Val Glu Lys Glu Leu Ser Ser Tyr Leu Gly Lys Glu Lys Leu 
    210                 215                 220                 


Ala Gly Ile Phe Thr Leu Glu Ser Phe Asn Lys Tyr Leu Gly Gln Gly 
225                 230                 235                 240 


Gly Lys Glu Asn Gln Arg Gly Ile Asp Phe Tyr Asn Gln Ile Ile Gly 
                245                 250                 255     


Gly Val Val Glu Lys Glu Gly Gly Ile Asn Leu Arg Gly Val Asn Gln 
            260                 265                 270         


Phe Leu Asn Leu Tyr Trp Gln Gln His Pro Asp Phe Thr Lys Glu Asp 
        275                 280                 285             


Arg Arg Ile Lys Met Val Pro Leu Tyr Lys Gln Ile Leu Ser Asp Arg 
    290                 295                 300                 


Ser Ser Leu Ser Phe Lys Ile Glu Ser Ile Glu Asn Asp Glu Glu Leu 
305                 310                 315                 320 


Lys Asn Ala Leu Leu Glu Cys Ala Asp Lys Leu Glu Leu Lys Asn Asp 
                325                 330                 335     


Glu Lys Lys Ser Ile Phe Glu Glu Val Cys Asp Leu Phe Ser Ser Val 
            340                 345                 350         


Lys Asn Leu Asp Leu Ser Gly Ile Tyr Ile Asn Arg Lys Asp Ile Asn 
        355                 360                 365             


Ser Val Ser Arg Ile Leu Thr Gly Asp Trp Ser Trp Leu Gln Ser Arg 
    370                 375                 380                 


Met Asn Val Tyr Ala Glu Glu Lys Phe Thr Thr Lys Ala Glu Lys Ala 
385                 390                 395                 400 


Arg Trp Gln Lys Ser Leu Asp Asp Glu Gly Glu Asn Lys Ser Lys Gly 
                405                 410                 415     


Phe Tyr Ser Leu Thr Asp Leu Asn Glu Val Leu Glu Tyr Ser Ser Glu 
            420                 425                 430         


Asn Val Ala Glu Thr Asp Ile Arg Ile Thr Asp Tyr Phe Glu His Arg 
        435                 440                 445             


Cys Arg Tyr Tyr Val Asp Lys Glu Thr Glu Met Phe Val Gln Gly Ser 
    450                 455                 460                 


Glu Leu Val Ala Leu Ser Leu Gln Glu Met Cys Asp Asp Ile Leu Lys 
465                 470                 475                 480 


Lys Arg Lys Ala Met Asn Thr Val Leu Glu Asn Leu Ser Ser Glu Asn 
                485                 490                 495     


Lys Leu Arg Glu Lys Thr Asp Asp Val Ala Val Ile Lys Glu Tyr Leu 
            500                 505                 510         


Asp Ala Val Gln Glu Leu Leu His Arg Ile Lys Pro Leu Lys Val Asn 
        515                 520                 525             


Gly Val Gly Asp Ser Thr Phe Tyr Ser Val Tyr Asp Ser Ile Tyr Ser 
    530                 535                 540                 


Ala Leu Ser Glu Val Ile Ser Val Tyr Asn Lys Thr Arg Asn Tyr Ile 
545                 550                 555                 560 


Thr Lys Lys Ala Ala Ser Pro Glu Lys Tyr Lys Leu Asn Phe Asp Asn 
                565                 570                 575     


Pro Thr Leu Ala Asp Gly Trp Asp Leu Asn Lys Glu Gln Ala Asn Thr 
            580                 585                 590         


Ser Val Ile Leu Arg Lys Asp Gly Met Phe Tyr Leu Gly Ile Met Asn 
        595                 600                 605             


Pro Lys Asn Lys Pro Lys Phe Ala Glu Lys Tyr Asp Cys Gly Asn Glu 
    610                 615                 620                 


Ser Cys Tyr Glu Lys Met Ile Tyr Lys Gln Phe Asp Ala Thr Lys Gln 
625                 630                 635                 640 


Ile Pro Lys Cys Ser Thr Gln Lys Lys Glu Val Gln Lys Tyr Phe Leu 
                645                 650                 655     


Ser Gly Ala Thr Glu Pro Tyr Ile Leu Asn Asp Lys Lys Ser Phe Lys 
            660                 665                 670         


Ser Glu Leu Ile Ile Thr Lys Asp Ile Trp Phe Met Asn Asn His Val 
        675                 680                 685             


Trp Asp Gly Glu Lys Phe Val Pro Lys Arg Asp Asn Glu Thr Arg Pro 
    690                 695                 700                 


Lys Lys Phe Gln Ile Gly Tyr Phe Lys Gln Thr Gly Asp Phe Asp Gly 
705                 710                 715                 720 


Tyr Lys Asn Ala Leu Ser Asn Trp Ile Ser Phe Cys Lys Asn Phe Leu 
                725                 730                 735     


Gln Ser Tyr Leu Ser Ala Thr Val Tyr Asp Tyr Asn Phe Lys Asn Ser 
            740                 745                 750         


Glu Glu Tyr Glu Gly Leu Asp Glu Phe Tyr Asn Tyr Leu Asn Ala Thr 
        755                 760                 765             


Cys Tyr Lys Leu Asn Phe Ile Asn Ile Pro Glu Thr Glu Ile Asn Lys 
    770                 775                 780                 


Met Val Ser Glu Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp 
785                 790                 795                 800 


Phe Ala Ser Gly Ser Thr Gly Met Pro Asn Met His Thr Leu Tyr Trp 
                805                 810                 815     


Lys Asn Leu Phe Ser Asp Glu Asn Leu Lys Asn Val Cys Leu Lys Leu 
            820                 825                 830         


Asn Gly Glu Ala Glu Leu Phe Tyr Arg Pro Ala Gly Ile Lys Glu Pro 
        835                 840                 845             


Val Ile His Lys Glu Gly Ser Tyr Leu Val Asn Arg Thr Thr Glu Asp 
    850                 855                 860                 


Gly Glu Ser Ile Pro Glu Lys Ile Tyr Phe Glu Ile Tyr Lys Asn Ala 
865                 870                 875                 880 


Asn Gly Lys Leu Glu Lys Leu Ser Asp Glu Ala Gln Asn Tyr Ile Ser 
                885                 890                 895     


Asn His Glu Val Val Ile Lys Lys Ala Gly His Glu Ile Ile Lys Asp 
            900                 905                 910         


Arg His Tyr Thr Glu Pro Lys Phe Leu Phe His Val Pro Leu Thr Ile 
        915                 920                 925             


Asn Phe Lys Ala Ser Gly Asn Ser Tyr Ser Ile Asn Glu Asn Val Arg 
    930                 935                 940                 


Lys Phe Leu Lys Asn Asn Pro Asp Val Asn Ile Ile Gly Leu Asp Arg 
945                 950                 955                 960 


Gly Glu Arg His Leu Ile Tyr Leu Ser Leu Ile Asn Gln Lys Gly Glu 
                965                 970                 975     


Ile Ile Lys Gln Phe Thr Phe Asn Glu Val Glu Arg Asn Lys Asn Gly 
            980                 985                 990         


Arg Thr Ile Lys Val Asn Tyr His  Glu Lys Leu Asp Gln  Arg Glu Lys 
        995                 1000                 1005             


Glu Arg  Asp Ala Ala Arg Lys  Ser Trp Gln Ala Ile  Gly Lys Ile 
    1010                 1015                 1020             


Ala Glu  Leu Lys Glu Gly Tyr  Leu Ser Ala Val Ile  His Gln Leu 
    1025                 1030                 1035             


Thr Lys  Leu Met Val Glu Tyr  Asn Ala Val Val Val  Met Glu Asp 
    1040                 1045                 1050             


Leu Asn  Phe Gly Phe Lys Arg  Gly Arg Phe His Val  Glu Lys Gln 
    1055                 1060                 1065             


Val Tyr  Gln Lys Phe Glu His  Ile Leu Ile Asp Lys  Ser Asn Tyr 
    1070                 1075                 1080             


Leu Val  Phe Lys Asp Arg Gly  Leu Asn Glu Pro Gly  Gly Val Leu 
    1085                 1090                 1095             


Asn Gly  Tyr Gln Ile Ala Gly  Gln Phe Glu Ser Phe  Gln Lys Leu 
    1100                 1105                 1110             


Gly Lys  Gln Ser Gly Met Leu  Phe Tyr Val Pro Ala  Gly Tyr Thr 
    1115                 1120                 1125             


Ser Lys  Ile Asp Pro Lys Thr  Gly Phe Val Ser Met  Met Asn Phe 
    1130                 1135                 1140             


Lys Asp  Leu Thr Asn Val His  Lys Lys Arg Asp Phe  Phe Ser Lys 
    1145                 1150                 1155             


Phe Asp  Asn Ile His Tyr Asp  Glu Ala Asn Gly Ser  Phe Val Phe 
    1160                 1165                 1170             


Thr Phe  Asp Tyr Lys Lys Phe  Asp Gly Lys Ala Lys  Glu Glu Met 
    1175                 1180                 1185             


Lys Leu  Thr Lys Trp Ser Val  Tyr Ser Arg Asp Lys  Arg Ile Val 
    1190                 1195                 1200             


Tyr Phe  Ala Lys Thr Lys Ser  Tyr Glu Asp Val Leu  Pro Thr Glu 
    1205                 1210                 1215             


Lys Leu  Gln Lys Ile Phe Glu  Ser Asn Gly Ile Asp  Tyr Lys Ser 
    1220                 1225                 1230             


Gly Asn  Asn Ile Gln Asp Ser  Val Met Ala Ile Gly  Ala Asp Leu 
    1235                 1240                 1245             


Lys Glu  Gly Ala Lys Pro Ser  Lys Glu Ile Ser Asp  Phe Trp Asp 
    1250                 1255                 1260             


Gly Leu  Leu Ser Asn Phe Lys  Leu Ile Leu Gln Met  Arg Asn Ser 
    1265                 1270                 1275             


Asn Ala  Arg Thr Gly Glu Asp  Tyr Ile Ile Ser Pro  Val Met Ala 
    1280                 1285                 1290             


Asp Asp  Gly Thr Phe Phe Asp  Ser Arg Glu Glu Phe  Lys Lys Gly 
    1295                 1300                 1305             


Glu Asp  Ala Lys Leu Pro Leu  Asp Ala Asp Ala Asn  Gly Ala Tyr 
    1310                 1315                 1320             


His Ile  Ala Leu Lys Gly Leu  Ser Leu Ile Asn Lys  Ile Asn Leu 
    1325                 1330                 1335             


Ser Lys  Asp Glu Glu Leu Lys  Lys Phe Asp Met Lys  Ile Ser Asn 
    1340                 1345                 1350             


Ala Asp  Trp Phe Lys Phe Ala  Gln Glu Lys Asn Tyr  Ala Lys 
    1355                 1360                 1365         


<210>  10
<211>  1264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  10

Met Glu Asn Tyr Gly Gly Phe Thr Gly Leu Tyr Pro Leu Gln Lys Thr 
1               5                   10                  15      


Leu Lys Phe Glu Leu Arg Pro Gln Gly Arg Thr Met Glu His Leu Val 
            20                  25                  30          


Ser Ser Asn Phe Phe Glu Glu Asp Arg Asp Arg Ala Glu Lys Tyr Lys 
        35                  40                  45              


Ile Val Lys Lys Val Ile Asp Asn Tyr His Lys Asp Phe Ile Asn Glu 
    50                  55                  60                  


Cys Leu Ser Lys Arg Ser Phe Asp Trp Thr Pro Leu Met Lys Thr Ser 
65                  70                  75                  80  


Glu Lys Tyr Tyr Ala Ser Lys Glu Lys Asn Gly Lys Lys Lys Gln Asp 
                85                  90                  95      


Leu Asp Gln Lys Ile Ile Pro Thr Ile Glu Asn Leu Ser Glu Lys Asp 
            100                 105                 110         


Arg Lys Glu Leu Glu Leu Glu Gln Lys Arg Met Arg Lys Glu Ile Val 
        115                 120                 125             


Ser Val Phe Lys Glu Asp Lys Arg Phe Lys Tyr Leu Phe Ser Glu Lys 
    130                 135                 140                 


Leu Phe Ser Ile Leu Leu Lys Asp Glu Asp Tyr Ser Lys Glu Lys Leu 
145                 150                 155                 160 


Thr Glu Lys Glu Ile Leu Ala Leu Lys Ser Phe Asn Lys Phe Ser Gly 
                165                 170                 175     


Tyr Phe Ile Gly Leu His Lys Asn Arg Ala Asn Phe Tyr Ser Glu Gly 
            180                 185                 190         


Asp Glu Ser Thr Ala Ile Ala Tyr Arg Ile Val Asn Glu Asn Phe Pro 
        195                 200                 205             


Lys Phe Leu Ser Asn Leu Lys Lys Tyr Arg Glu Val Cys Glu Lys Tyr 
    210                 215                 220                 


Pro Glu Ile Ile Gln Asp Ala Glu Gln Ser Leu Ala Gly Leu Asn Ile 
225                 230                 235                 240 


Lys Met Asp Asp Ile Phe Pro Met Glu Asn Phe Asn Lys Val Met Thr 
                245                 250                 255     


Gln Asp Gly Ile Asp Leu Tyr Asn Leu Ala Ile Gly Gly Lys Ala Gln 
            260                 265                 270         


Ala Leu Gly Glu Lys Gln Lys Gly Leu Asn Glu Phe Leu Asn Glu Val 
        275                 280                 285             


Asn Gln Ser Tyr Lys Lys Gly Asn Asp Arg Ile Arg Met Thr Pro Leu 
    290                 295                 300                 


Phe Lys Gln Ile Leu Ser Glu Arg Thr Ser Tyr Ser Tyr Ile Leu Asp 
305                 310                 315                 320 


Ala Phe Asp Asp Asn Ser Gln Leu Ile Thr Ser Ile Asn Gly Phe Phe 
                325                 330                 335     


Thr Glu Val Glu Lys Asp Lys Glu Gly Asn Thr Phe Asp Arg Ala Val 
            340                 345                 350         


Gly Leu Ile Ala Ser Tyr Met Lys Tyr Asp Leu Ser Arg Val Tyr Ile 
        355                 360                 365             


Arg Lys Ala Asp Leu Asn Lys Val Ser Met Glu Ile Phe Gly Ser Trp 
    370                 375                 380                 


Glu Arg Leu Gly Gly Leu Leu Arg Ile Phe Lys Ser Glu Leu Tyr Gly 
385                 390                 395                 400 


Asp Val Asn Ala Glu Lys Thr Ser Lys Lys Val Asp Lys Trp Leu Asn 
                405                 410                 415     


Ser Gly Glu Phe Ser Leu Ser Asp Val Ile Asn Ala Ile Ala Gly Ser 
            420                 425                 430         


Lys Ser Ala Glu Thr Phe Asp Glu Tyr Ile Leu Lys Met Arg Val Ala 
        435                 440                 445             


Arg Gly Glu Ile Asp Asn Ala Leu Glu Lys Ile Lys Cys Ile Asn Gly 
    450                 455                 460                 


Asn Phe Ser Glu Asp Glu Asn Ser Lys Met Ile Ile Lys Ala Ile Leu 
465                 470                 475                 480 


Asp Ser Val Gln Arg Leu Phe His Leu Phe Ser Ser Phe Gln Val Arg 
                485                 490                 495     


Ala Asp Phe Ser Gln Asp Gly Asp Phe Tyr Ala Glu Tyr Asn Glu Ile 
            500                 505                 510         


Tyr Glu Lys Leu Phe Ala Ile Val Pro Leu Tyr Asn Arg Val Arg Asn 
        515                 520                 525             


Tyr Leu Thr Lys Asn Asn Leu Ser Met Lys Lys Ile Lys Leu Asn Phe 
    530                 535                 540                 


Lys Asn Pro Ala Leu Ala Asn Gly Trp Asp Leu Asn Lys Glu Tyr Asp 
545                 550                 555                 560 


Asn Thr Ala Val Ile Phe Leu Arg Glu Gly Lys Tyr Tyr Leu Gly Ile 
                565                 570                 575     


Met Asn Pro Ser Lys Lys Lys Asn Ile Lys Phe Glu Glu Gly Ser Gly 
            580                 585                 590         


Thr Gly Pro Phe Tyr Lys Lys Met Ala Tyr Lys Leu Leu Pro Asp Pro 
        595                 600                 605             


Asn Lys Met Leu Pro Lys Val Phe Phe Ala Lys Lys Asn Ile Asn Tyr 
    610                 615                 620                 


Tyr Asn Pro Ser Asp Glu Ile Val Lys Gly Tyr Lys Ala Gly Lys Tyr 
625                 630                 635                 640 


Lys Lys Gly Glu Asn Phe Asp Ile Asp Phe Cys His Lys Leu Ile Asp 
                645                 650                 655     


Phe Phe Lys Glu Ser Ile Gln Lys Asn Glu Asp Trp Arg Ala Phe Asn 
            660                 665                 670         


Tyr Leu Phe Ser Ala Thr Glu Ser Tyr Lys Asp Ile Ser Asp Phe Tyr 
        675                 680                 685             


Ser Glu Val Glu Asp Gln Gly Tyr Arg Met Tyr Phe Leu Asn Val Pro 
    690                 695                 700                 


Val Ala Asn Ile Asp Glu Tyr Val Glu Lys Gly Asp Leu Phe Leu Phe 
705                 710                 715                 720 


Gln Ile Tyr Asn Lys Asp Phe Ala Ser Gly Ala Lys Gly Asn Lys Asp 
                725                 730                 735     


Met His Thr Ile Tyr Trp Asn Ala Ala Phe Ser Asp Glu Asn Leu Arg 
            740                 745                 750         


Asn Val Val Val Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr Arg Asp 
        755                 760                 765             


Lys Ser Ile Ile Glu Pro Ile Cys His Lys Lys Gly Glu Met Leu Val 
    770                 775                 780                 


Asn Arg Thr Cys Phe Asp Lys Thr Pro Val Pro Asp Lys Ile His Lys 
785                 790                 795                 800 


Glu Leu Phe Asp Tyr His Asn Gly Arg Ala Lys Thr Leu Ser Ile Glu 
                805                 810                 815     


Ala Lys Gly Tyr Leu Asp Arg Val Gly Val Phe Gln Ala Ser Tyr Glu 
            820                 825                 830         


Ile Ile Lys Asp Arg Arg Tyr Ser Glu Asn Lys Met Tyr Phe His Val 
        835                 840                 845             


Pro Leu Lys Leu Asn Phe Lys Ala Asp Gly Lys Lys Asn Leu Asn Lys 
    850                 855                 860                 


Met Val Ile Glu Lys Phe Leu Ser Asp Lys Asp Val His Ile Ile Gly 
865                 870                 875                 880 


Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Tyr Ser Val Ile Asp Arg 
                885                 890                 895     


Arg Gly Asn Ile Ile Asp Gln Asp Ser Leu Asn Ile Ile Asp Gly Phe 
            900                 905                 910         


Asp Tyr Gln Lys Lys Leu Gly Gln Arg Glu Ile Glu Arg Arg Glu Ala 
        915                 920                 925             


Arg Gln Ser Trp Asn Ser Ile Gly Lys Ile Lys Asp Leu Lys Glu Gly 
    930                 935                 940                 


Tyr Leu Ser Lys Ala Val His Lys Val Ser Lys Met Val Leu Glu Tyr 
945                 950                 955                 960 


Asn Ala Ile Val Val Leu Glu Asp Leu Asn Phe Gly Phe Lys Arg Gly 
                965                 970                 975     


Arg Phe Lys Val Glu Lys Gln Val Tyr Gln Lys Phe Glu Lys Met Leu 
            980                 985                 990         


Ile Asp Lys Leu Asn Tyr Leu Val  Phe Lys Glu Val Leu  Asp Ser Arg 
        995                 1000                 1005             


Asp Ala  Gly Gly Val Leu Asn  Ala Tyr Gln Leu Thr  Thr Gln Leu 
    1010                 1015                 1020             


Glu Ser  Phe Asn Lys Leu Gly  Lys Gln Ser Gly Ile  Leu Phe Tyr 
    1025                 1030                 1035             


Val Pro  Ala Ala Tyr Thr Ser  Lys Ile Asp Pro Thr  Thr Gly Phe 
    1040                 1045                 1050             


Val Ser  Leu Phe Asn Thr Ser  Arg Ile Glu Ser Asp  Ser Glu Lys 
    1055                 1060                 1065             


Lys Asp  Phe Leu Ser Gly Phe  Asp Ser Ile Val Tyr  Ser Ala Lys 
    1070                 1075                 1080             


Asp Gly  Gly Ile Phe Ala Phe  Lys Phe Asp Tyr Arg  Asn Arg Asn 
    1085                 1090                 1095             


Phe Gln  Arg Glu Lys Thr Asp  His Lys Asn Ile Trp  Thr Val Tyr 
    1100                 1105                 1110             


Thr Asn  Gly Asp Arg Ile Lys  Tyr Lys Gly Arg Met  Lys Gly Tyr 
    1115                 1120                 1125             


Glu Ile  Thr Ser Pro Thr Lys  Arg Ile Lys Asp Val  Leu Ser Ser 
    1130                 1135                 1140             


Ser Gly  Ile Arg Tyr Asp Asp  Gly Gln Glu Leu Arg  Asp Ser Ile 
    1145                 1150                 1155             


Ile Gln  Ser Gly Asn Lys Val  Leu Ile Asn Glu Val  Tyr Asn Ser 
    1160                 1165                 1170             


Phe Ile  Asp Thr Leu Gln Met  Arg Asn Ser Asp Gly  Glu Gln Asp 
    1175                 1180                 1185             


Tyr Ile  Ile Ser Pro Val Lys  Asn Arg Asn Gly Glu  Phe Phe Arg 
    1190                 1195                 1200             


Thr Asp  Pro Asp Arg Arg Glu  Leu Pro Val Asp Ala  Asp Ala Asn 
    1205                 1210                 1215             


Gly Ala  Tyr His Ile Ala Leu  Arg Gly Glu Leu Leu  Met Gln Lys 
    1220                 1225                 1230             


Ile Ala  Glu Asp Phe Asp Pro  Lys Ser Asp Lys Phe  Thr Met Pro 
    1235                 1240                 1245             


Lys Met  Glu His Lys Asp Trp  Phe Glu Phe Met Gln  Thr Arg Gly 
    1250                 1255                 1260             


Asp 
    


<210>  11
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  11

Met Glu Val Gln Lys Thr Val Met Lys Thr Leu Ser Leu Arg Ile Leu 
1               5                   10                  15      


Arg Pro Leu Tyr Ser Gln Glu Ile Glu Lys Glu Ile Lys Glu Glu Lys 
            20                  25                  30          


Glu Arg Arg Lys Gln Ala Gly Gly Thr Gly Glu Leu Asp Gly Gly Phe 
        35                  40                  45              


Tyr Lys Lys Leu Glu Lys Lys His Ser Glu Met Phe Ser Phe Asp Arg 
    50                  55                  60                  


Leu Asn Leu Leu Leu Asn Gln Leu Gln Arg Glu Ile Ala Lys Val Tyr 
65                  70                  75                  80  


Asn His Ala Ile Ser Glu Leu Tyr Ile Ala Thr Ile Ala Gln Gly Asn 
                85                  90                  95      


Lys Ser Asn Lys His Tyr Ile Ser Ser Ile Val Tyr Asn Arg Ala Tyr 
            100                 105                 110         


Gly Tyr Phe Tyr Asn Ala Tyr Ile Ala Leu Gly Ile Cys Ser Lys Val 
        115                 120                 125             


Glu Ala Asn Phe Arg Ser Asn Glu Leu Leu Thr Gln Gln Ser Ala Leu 
    130                 135                 140                 


Pro Thr Ala Lys Ser Asp Asn Phe Pro Ile Val Leu His Lys Gln Lys 
145                 150                 155                 160 


Gly Ala Glu Gly Glu Asp Gly Gly Phe Arg Ile Ser Thr Glu Gly Ser 
                165                 170                 175     


Asp Leu Ile Phe Glu Ile Pro Ile Pro Phe Tyr Glu Tyr Asn Gly Glu 
            180                 185                 190         


Asn Arg Lys Glu Pro Tyr Lys Trp Val Lys Lys Gly Gly Gln Lys Pro 
        195                 200                 205             


Val Leu Lys Leu Ile Leu Ser Thr Phe Arg Arg Gln Arg Asn Lys Gly 
    210                 215                 220                 


Trp Ala Lys Asp Glu Gly Thr Asp Ala Glu Ile Arg Lys Val Thr Glu 
225                 230                 235                 240 


Gly Lys Tyr Gln Val Ser Gln Ile Glu Ile Asn Arg Gly Lys Lys Leu 
                245                 250                 255     


Gly Glu His Gln Lys Trp Phe Ala Asn Phe Ser Ile Glu Gln Pro Ile 
            260                 265                 270         


Tyr Glu Arg Lys Pro Asn Arg Ser Ile Val Gly Gly Leu Asp Val Gly 
        275                 280                 285             


Ile Arg Ser Pro Leu Val Cys Ala Ile Asn Asn Ser Phe Ser Arg Tyr 
    290                 295                 300                 


Ser Val Asp Ser Asn Asp Val Phe Lys Phe Ser Lys Gln Val Phe Ala 
305                 310                 315                 320 


Phe Arg Arg Arg Leu Leu Ser Lys Asn Ser Leu Lys Arg Lys Gly His 
                325                 330                 335     


Gly Ala Ala His Lys Leu Glu Pro Ile Thr Glu Met Thr Glu Lys Asn 
            340                 345                 350         


Asp Lys Phe Arg Lys Lys Ile Ile Glu Arg Trp Ala Lys Glu Val Thr 
        355                 360                 365             


Asn Phe Phe Val Lys Asn Gln Val Gly Ile Val Gln Ile Glu Asp Leu 
    370                 375                 380                 


Ser Thr Met Lys Asp Arg Glu Asp His Phe Phe Asn Gln Tyr Leu Arg 
385                 390                 395                 400 


Gly Phe Trp Pro Tyr Tyr Gln Met Gln Thr Leu Ile Glu Asn Lys Leu 
                405                 410                 415     


Lys Glu Tyr Gly Ile Glu Val Lys Arg Val Gln Ala Lys Tyr Thr Ser 
            420                 425                 430         


Gln Leu Cys Ser Asn Pro Asn Cys Arg Tyr Trp Asn Asn Tyr Phe Asn 
        435                 440                 445             


Phe Glu Tyr Arg Lys Val Asn Lys Phe Pro Lys Phe Lys Cys Glu Lys 
    450                 455                 460                 


Cys Asn Leu Glu Ile Ser Ala Asp Tyr Asn Ala Ala Arg Asn Leu Ser 
465                 470                 475                 480 


Thr Pro Asp Ile Glu Lys Phe Val Ala Lys Ala Thr Lys Gly Ile Asn 
                485                 490                 495     


Leu Pro Glu Lys 
            500 


<210>  12
<211>  1261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  12

Met Ile Ile His Asn Cys Tyr Ile Gly Gly Ser Phe Met Lys Lys Ile 
1               5                   10                  15      


Asp Ser Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys 
            20                  25                  30          


Leu Ile Pro Ile Gly Ala Thr Gln Ser Asn Phe Asp Leu Asn Lys Met 
        35                  40                  45              


Leu Asp Glu Asp Lys Lys Arg Ala Glu Asn Tyr Ser Lys Ala Lys Ser 
    50                  55                  60                  


Ile Ile Asp Lys Tyr His Arg Phe Phe Ile Asp Lys Val Leu Ser Ser 
65                  70                  75                  80  


Val Thr Glu Asn Lys Ala Phe Asp Ser Phe Leu Glu Asp Val Arg Ala 
                85                  90                  95      


Tyr Ala Glu Leu Tyr Tyr Arg Ser Asn Lys Asp Asp Ser Asp Lys Ala 
            100                 105                 110         


Ser Met Lys Thr Leu Glu Ser Lys Met Arg Lys Phe Ile Ala Leu Ala 
        115                 120                 125             


Leu Gln Ser Asp Glu Gly Phe Lys Asp Leu Phe Gly Gln Asn Leu Ile 
    130                 135                 140                 


Lys Lys Thr Leu Pro Glu Phe Leu Glu Ser Asp Thr Asp Lys Glu Ile 
145                 150                 155                 160 


Ile Ala Glu Phe Asp Gly Phe Ser Thr Tyr Phe Thr Gly Phe Phe Asn 
                165                 170                 175     


Asn Arg Lys Asn Met Tyr Ser Ala Asp Asp Gln Pro Thr Ala Ile Ser 
            180                 185                 190         


Tyr Arg Cys Ile Asn Asp Asn Leu Pro Lys Phe Leu Asp Asn Val Arg 
        195                 200                 205             


Thr Phe Lys Asn Ser Asp Val Ala Ser Ile Leu Asn Asp Asn Leu Lys 
    210                 215                 220                 


Ile Leu Asn Glu Asp Phe Asp Gly Ile Tyr Gly Thr Ser Ala Glu Asp 
225                 230                 235                 240 


Val Phe Asn Val Asp Tyr Phe Pro Phe Val Leu Ser Gln Lys Gly Ile 
                245                 250                 255     


Glu Ala Tyr Asn Ser Ile Leu Gly Gly Tyr Thr Asn Ser Asp Gly Ser 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Asn 
        275                 280                 285             


Glu Asn Ile His Arg Ile Pro Lys Met Lys Gln Leu Phe Lys Gln Ile 
    290                 295                 300                 


Leu Ser Glu Arg Glu Ser Val Ser Phe Ile Pro Glu Lys Phe Asp Ser 
305                 310                 315                 320 


Asp Asp Asp Val Leu Ser Ser Ile Asn Asp Tyr Tyr Leu Glu Arg Asp 
                325                 330                 335     


Gly Gly Lys Val Leu Ser Ile Glu Lys Thr Val Glu Lys Ile Glu Lys 
            340                 345                 350         


Leu Phe Ser Ala Val Thr Asp Tyr Ser Thr Asp Gly Ile Phe Val Lys 
        355                 360                 365             


Asn Ala Ala Glu Leu Thr Ala Val Cys Ser Gly Ala Phe Gly Tyr Trp 
    370                 375                 380                 


Gly Thr Val Gln Asn Ala Trp Asn Asn Glu Tyr Asp Ala Leu Asn Gly 
385                 390                 395                 400 


Tyr Lys Glu Thr Glu Lys Tyr Ile Asp Lys Arg Lys Lys Ala Tyr Lys 
                405                 410                 415     


Ser Ile Glu Ser Phe Ser Leu Ala Asp Ile Gln Lys Tyr Ala Asp Val 
            420                 425                 430         


Ser Glu Ser Ser Glu Thr Asn Ala Glu Val Thr Glu Trp Leu Arg Asn 
        435                 440                 445             


Glu Ile Lys Glu Lys Cys Asn Leu Ala Val Gln Gly Tyr Glu Ser Ser 
    450                 455                 460                 


Lys Asp Leu Ile Ser Lys Pro Tyr Thr Glu Ser Lys Lys Leu Phe Asn 
465                 470                 475                 480 


Asn Asp Asn Ala Val Glu Leu Ile Lys Asn Ala Leu Asp Ser Val Lys 
                485                 490                 495     


Glu Leu Glu Asn Val Leu Arg Leu Leu Leu Gly Thr Gly Lys Glu Glu 
            500                 505                 510         


Ser Lys Asp Glu Asn Phe Tyr Gly Glu Phe Leu Pro Cys Tyr Glu Arg 
        515                 520                 525             


Ile Cys Glu Val Asp Ser Leu Tyr Asp Lys Val Arg Asn Tyr Met Thr 
    530                 535                 540                 


Gln Lys Leu Tyr Lys Thr Asp Lys Ile Lys Leu Asn Phe Gln Asn Pro 
545                 550                 555                 560 


Gln Phe Leu Gly Gly Trp Asp Arg Asn Lys Glu Ala Asp Tyr Ser Ala 
                565                 570                 575     


Val Leu Leu Arg Arg Asn Ser Leu Tyr Tyr Ile Ala Ile Met Pro Ser 
            580                 585                 590         


Gly Tyr Lys Arg Val Phe Glu Lys Ile Pro Ala Pro Lys Ala Asp Glu 
        595                 600                 605             


Thr Val Tyr Glu Lys Val Ile Tyr Lys Leu Leu Pro Gly Pro Asn Lys 
    610                 615                 620                 


Met Leu Pro Lys Val Phe Phe Ser Lys Lys Gly Ile Glu Thr Phe Asn 
625                 630                 635                 640 


Pro Pro Lys Glu Ile Leu Glu Lys Tyr Glu Leu Gly Thr His Lys Thr 
                645                 650                 655     


Gly Asp Gly Phe Asn Leu Asp Asp Cys His Ala Leu Ile Asp Tyr Phe 
            660                 665                 670         


Lys Ser Ala Leu Asp Val His Ser Asp Trp Ser Asn Phe Gly Phe Arg 
        675                 680                 685             


Phe Ser Asp Thr Ser Thr Tyr Lys Asn Ile Ala Asp Phe Tyr Asn Glu 
    690                 695                 700                 


Val Lys Asn Gln Gly Tyr Lys Ile Thr Phe Cys Asp Val Pro Gln Ser 
705                 710                 715                 720 


Tyr Ile Asn Glu Leu Val Asp Glu Gly Lys Leu Tyr Leu Phe Gln Leu 
                725                 730                 735     


Tyr Asn Lys Asp Phe Ser Glu His Ser Lys Gly Thr Pro Asn Leu His 
            740                 745                 750         


Thr Leu Tyr Phe Lys Met Leu Phe Asp Glu Arg Asn Leu Glu Asn Val 
        755                 760                 765             


Val Phe Lys Leu Asn Gly Glu Ala Glu Met Phe Tyr Arg Glu Ala Ser 
    770                 775                 780                 


Ile Ser Lys Asp Asp Met Ile Val His Pro Lys Asn Gln Pro Ile Lys 
785                 790                 795                 800 


Asn Lys Asn Glu Gln Asn Ser Arg Lys Gln Ser Thr Phe Glu Tyr Asp 
                805                 810                 815     


Ile Val Lys Asp Arg Arg Tyr Thr Val Asp Gln Phe Met Leu His Ile 
            820                 825                 830         


Pro Ile Thr Leu Asn Phe Thr Ala Asn Gly Gly Thr Asn Ile Asn Asn 
        835                 840                 845             


Glu Val Arg Lys Ala Leu Lys Asp Cys Asp Lys Asn Tyr Val Ile Gly 
    850                 855                 860                 


Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Cys Val Val Asp Ser 
865                 870                 875                 880 


Glu Gly Arg Ile Ile Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Glu 
                885                 890                 895     


Tyr Asn Gly Asn Thr Tyr Ser Thr Asp Tyr His Ala Leu Leu Asp Lys 
            900                 905                 910         


Lys Glu Lys Glu Arg Leu Glu Ser Arg Lys Ala Trp Lys Thr Val Glu 
        915                 920                 925             


Asn Ile Lys Glu Leu Lys Glu Gly Tyr Ile Ser Gln Val Val His Lys 
    930                 935                 940                 


Ile Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Val Met Glu Asp 
945                 950                 955                 960 


Leu Asn Leu Gly Phe Lys Gln Gly Arg Ser Gly Lys Phe Glu Lys Ser 
                965                 970                 975     


Val Tyr Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Phe 
            980                 985                 990         


Ala Asp Lys Lys Lys Ser Pro Glu  Glu Ile Gly Ser Val  Leu Asn Ala 
        995                 1000                 1005             


Tyr Gln  Leu Thr Asn Ala Phe  Glu Ser Phe Glu Lys  Met Gly Lys 
    1010                 1015                 1020             


Gln Asn  Gly Phe Ile Phe Tyr  Val Pro Ala Tyr Leu  Thr Ser Lys 
    1025                 1030                 1035             


Ile Asp  Pro Thr Thr Gly Phe  Ala Asp Leu Leu His  Pro Ser Ser 
    1040                 1045                 1050             


Lys Gln  Ser Lys Glu Ser Met  Arg Asp Phe Val Gly  Arg Phe Asp 
    1055                 1060                 1065             


Ser Ile  Thr Phe Asn Lys Thr  Glu Asn Tyr Phe Glu  Phe Glu Leu 
    1070                 1075                 1080             


Asp Tyr  Asn Lys Phe Pro Arg  Cys Asn Thr Asp Tyr  Arg Lys Lys 
    1085                 1090                 1095             


Trp Thr  Val Cys Thr Tyr Gly  Ser Arg Ile Lys Thr  Phe Arg Asn 
    1100                 1105                 1110             


Pro Glu  Lys Asn Ser Glu Trp  Asp Asn Lys Thr Val  Glu Leu Thr 
    1115                 1120                 1125             


Pro Ala  Phe Met Ala Leu Phe  Glu Lys Tyr Ser Ile  Asp Val Asn 
    1130                 1135                 1140             


Gly Asp  Ile Lys Ala Gln Ile  Met Ser Val Asp Lys  Lys Asp Phe 
    1145                 1150                 1155             


Phe Val  Glu Leu Ile Gly Leu  Leu Arg Leu Thr Leu  Gln Met Arg 
    1160                 1165                 1170             


Asn Ser  Glu Thr Gly Lys Val  Asp Arg Asp Tyr Leu  Ile Ser Pro 
    1175                 1180                 1185             


Val Lys  Asn Ser Glu Gly Val  Phe Tyr Asn Ser Asp  Asp Tyr Lys 
    1190                 1195                 1200             


Gly Ile  Glu Asn Ala Ser Leu  Pro Lys Asp Ala Asp  Ala Asn Gly 
    1205                 1210                 1215             


Ala Tyr  Asn Ile Ala Arg Lys  Gly Leu Trp Ile Ile  Glu Gln Ile 
    1220                 1225                 1230             


Lys Ala  Cys Glu Asn Asp Ala  Glu Leu Asn Lys Ile  Arg Leu Ala 
    1235                 1240                 1245             


Ile Ser  Asn Ala Glu Trp Leu  Glu Tyr Ala Gln Lys  Lys 
    1250                 1255                 1260     


<210>  13
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  13

Met Lys Asp Tyr Ile Arg Lys Thr Leu Ser Leu Arg Ile Leu Arg Pro 
1               5                   10                  15      


Tyr Tyr Gly Glu Glu Ile Glu Lys Glu Ile Ala Ala Ala Lys Lys Lys 
            20                  25                  30          


Ser Gln Ala Glu Gly Gly Asp Gly Ala Leu Asp Asn Lys Phe Trp Asp 
        35                  40                  45              


Arg Leu Lys Ala Glu His Pro Glu Ile Ile Ser Ser Arg Glu Phe Tyr 
    50                  55                  60                  


Asp Leu Leu Asp Ala Ile Gln Arg Glu Thr Thr Leu Tyr Tyr Asn Arg 
65                  70                  75                  80  


Ala Ile Ser Lys Leu Tyr His Ser Leu Ile Val Glu Arg Glu Gln Val 
                85                  90                  95      


Ser Thr Ala Lys Ala Leu Ser Ala Gly Pro Tyr His Glu Phe Arg Glu 
            100                 105                 110         


Lys Phe Asn Ala Tyr Ile Ser Leu Gly Leu Arg Glu Lys Ile Gln Ser 
        115                 120                 125             


Asn Phe Arg Arg Lys Glu Leu Ala Arg Tyr Gln Val Ala Leu Pro Thr 
    130                 135                 140                 


Ala Lys Ser Asp Thr Phe Pro Ile Pro Ile Tyr Lys Gly Phe Asp Lys 
145                 150                 155                 160 


Asn Gly Lys Gly Gly Phe Lys Val Arg Glu Ile Glu Asn Gly Asp Phe 
                165                 170                 175     


Val Ile Asp Leu Pro Leu Met Ala Tyr His Arg Val Gly Gly Lys Ala 
            180                 185                 190         


Gly Arg Glu Tyr Ile Glu Leu Asp Arg Pro Pro Ala Val Leu Asn Val 
        195                 200                 205             


Pro Val Ile Leu Ser Thr Ser Arg Arg Arg Ala Asn Lys Thr Trp Phe 
    210                 215                 220                 


Arg Asp Glu Gly Thr Asp Ala Glu Ile Arg Arg Val Met Ala Gly Glu 
225                 230                 235                 240 


Tyr Lys Val Ser Trp Val Glu Ile Leu Gln Arg Lys Arg Phe Gly Lys 
                245                 250                 255     


Pro Tyr Gly Gly Trp Tyr Val Asn Phe Thr Ile Lys Tyr Gln Pro Arg 
            260                 265                 270         


Asp Tyr Gly Leu Asp Pro Lys Val Lys Gly Gly Ile Asp Ile Gly Leu 
        275                 280                 285             


Ser Ser Pro Leu Val Cys Ala Val Thr Asn Ser Leu Ala Arg Leu Thr 
    290                 295                 300                 


Ile Arg Asp Asn Asp Leu Val Ala Phe Asn Arg Lys Ala Met Ala Arg 
305                 310                 315                 320 


Arg Arg Thr Leu Leu Arg Gln Asn Arg Tyr Lys Arg Ser Gly His Gly 
                325                 330                 335     


Ser Ala Asn Lys Leu Lys Pro Ile Glu Ala Leu Thr Glu Lys Asn Glu 
            340                 345                 350         


Leu Tyr Arg Lys Ala Ile Met Arg Arg Trp Ala Arg Glu Ala Ala Asp 
        355                 360                 365             


Phe Phe Arg Gln His Arg Ala Ala Thr Val Asn Met Glu Asp Leu Thr 
    370                 375                 380                 


Gly Ile Lys Asp Arg Glu Asp Tyr Phe Ser Gln Met Leu Arg Cys Tyr 
385                 390                 395                 400 


Trp Asn Tyr Ser Gln Leu Gln Thr Met Leu Glu Asn Lys Leu Lys Glu 
                405                 410                 415     


Tyr Gly Ile Ala Val Lys Tyr Ile Glu Pro Lys Asp Thr Ser Lys Thr 
            420                 425                 430         


Cys His Ser Cys Gly His Val Asn Glu Tyr Phe Asp Phe Asn Tyr Arg 
        435                 440                 445             


Ser Ala His Lys Phe Pro Met Phe Lys Cys Glu Lys Cys Gly Val Glu 
    450                 455                 460                 


Cys Gly Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Gln Ala 
465                 470                 475             


<210>  14
<211>  1229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  14

Met Lys Glu Gln Phe Ile Asn Arg Tyr Pro Leu Ser Lys Thr Leu Arg 
1               5                   10                  15      


Phe Ser Leu Ile Pro Val Gly Glu Thr Glu Asn Asn Phe Asn Lys Asn 
            20                  25                  30          


Leu Leu Leu Lys Lys Asp Lys Gln Arg Ala Glu Asn Tyr Glu Lys Val 
        35                  40                  45              


Lys Cys Tyr Ile Asp Arg Phe His Lys Glu Tyr Ile Glu Ser Val Leu 
    50                  55                  60                  


Ser Lys Ala Arg Ile Glu Lys Val Asn Glu Tyr Ala Asn Leu Tyr Trp 
65                  70                  75                  80  


Lys Ser Asn Lys Asp Asp Ser Asp Ile Lys Ala Met Glu Ser Leu Glu 
                85                  90                  95      


Asn Asp Met Arg Lys Gln Ile Ser Lys Gln Leu Thr Ser Thr Glu Ile 
            100                 105                 110         


Tyr Lys Lys Arg Leu Phe Gly Lys Glu Leu Ile Cys Glu Asp Leu Pro 
        115                 120                 125             


Ser Phe Leu Thr Asp Lys Asp Glu Arg Glu Thr Val Glu Cys Phe Arg 
    130                 135                 140                 


Ser Phe Thr Thr Tyr Phe Lys Gly Phe Asn Thr Asn Arg Glu Asn Met 
145                 150                 155                 160 


Tyr Ser Ser Asp Gly Lys Ser Thr Ala Ile Ala Tyr Arg Cys Ile Asn 
                165                 170                 175     


Asp Asn Leu Pro Arg Phe Leu Asp Asn Val Lys Ser Phe Gln Lys Val 
            180                 185                 190         


Phe Asp Asn Leu Ser Asp Glu Thr Ile Thr Lys Leu Asn Thr Asp Leu 
        195                 200                 205             


Tyr Asn Ile Phe Gly Arg Asn Ile Glu Asp Ile Phe Ser Val Asp Tyr 
    210                 215                 220                 


Phe Glu Phe Val Leu Thr Gln Ser Gly Ile Glu Ile Tyr Asn Ser Met 
225                 230                 235                 240 


Ile Gly Gly Tyr Thr Cys Ser Asp Lys Thr Lys Ile Gln Gly Leu Asn 
                245                 250                 255     


Glu Cys Ile Asn Leu Tyr Asn Gln Gln Val Ala Lys Asn Glu Lys Ser 
            260                 265                 270         


Lys Lys Leu Pro Leu Met Lys Pro Leu Tyr Lys Gln Ile Leu Ser Glu 
        275                 280                 285             


Lys Asp Ser Val Ser Phe Ile Pro Glu Lys Phe Asn Ser Asp Asn Glu 
    290                 295                 300                 


Val Leu His Ala Ile Asp Asp Tyr Tyr Thr Gly His Ile Gly Asp Phe 
305                 310                 315                 320 


Asp Leu Leu Thr Glu Leu Leu Gln Ser Leu Asn Thr Tyr Asn Ala Asn 
                325                 330                 335     


Gly Ile Phe Val Lys Ser Gly Val Ala Ile Thr Asp Ile Ser Asn Gly 
            340                 345                 350         


Ala Phe Asn Ser Trp Asn Val Leu Arg Ser Ala Trp Asn Glu Lys Tyr 
        355                 360                 365             


Glu Ala Leu His Pro Val Thr Ser Lys Thr Lys Ile Asp Lys Tyr Ile 
    370                 375                 380                 


Glu Lys Gln Asp Lys Ile Tyr Lys Ala Ile Lys Ser Phe Ser Leu Phe 
385                 390                 395                 400 


Glu Leu Gln Ser Leu Gly Asn Glu Asn Gly Asn Glu Ile Thr Asp Trp 
                405                 410                 415     


Tyr Ile Ser Ser Ile Asn Glu Ser Asn Ser Lys Ile Lys Glu Ala Tyr 
            420                 425                 430         


Leu Gln Ala Gln Lys Leu Leu Asn Ser Asp Tyr Glu Lys Ser Tyr Asn 
        435                 440                 445             


Lys Arg Leu Tyr Lys Asn Glu Lys Ala Thr Glu Leu Val Lys Asn Leu 
    450                 455                 460                 


Leu Asp Ala Ile Lys Glu Phe Gln Lys Leu Ile Lys Pro Leu Asn Gly 
465                 470                 475                 480 


Thr Gly Lys Glu Glu Asn Lys Asp Glu Leu Phe Tyr Gly Lys Phe Thr 
                485                 490                 495     


Ser Tyr Tyr Asp Ser Ile Ala Asp Ile Asp Arg Leu Tyr Asp Lys Val 
            500                 505                 510         


Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser Lys Asp Lys Ile Lys Leu 
        515                 520                 525             


Asn Phe Asp Asn Pro Gln Leu Leu Gly Gly Trp Asp Lys Asn Lys Glu 
    530                 535                 540                 


Ser Asp Tyr Arg Thr Val Leu Leu His Lys Asp Gly Leu Tyr Tyr Leu 
545                 550                 555                 560 


Ala Val Met Asp Lys Ser His Ser Lys Ala Phe Val Asp Ala Pro Glu 
                565                 570                 575     


Ile Thr Ser Asp Asp Lys Asp Tyr Tyr Glu Lys Met Glu Tyr Lys Leu 
            580                 585                 590         


Leu Pro Gly Pro Asn Lys Met Leu Pro Lys Val Phe Phe Ala Ser Lys 
        595                 600                 605             


Asn Ile Asp Thr Phe Gln Pro Ser Asp Arg Ile Leu Asp Ile Arg Lys 
    610                 615                 620                 


Arg Glu Ser Phe Lys Lys Gly Ala Thr Phe Asn Lys Ala Glu Cys His 
625                 630                 635                 640 


Glu Phe Ile Asp Tyr Phe Lys Asp Ser Ile Lys Lys His Asp Asp Trp 
                645                 650                 655     


Ser Gln Phe Gly Phe Lys Phe Ser Pro Thr Glu Ser Tyr Asn Asp Ile 
            660                 665                 670         


Ser Glu Phe Tyr Arg Glu Ile Ser Asp Gln Gly Tyr Ser Val Arg Phe 
        675                 680                 685             


Asn Lys Ile Ser Lys Asn Tyr Ile Asp Gly Leu Val Asn Asn Gly Tyr 
    690                 695                 700                 


Ile Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Lys Tyr Ser Lys 
705                 710                 715                 720 


Gly Thr Pro Asn Leu His Thr Leu Tyr Phe Lys Met Leu Phe Asp Glu 
                725                 730                 735     


Arg Asn Leu Ser Asn Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Met 
            740                 745                 750         


Phe Tyr Arg Glu Ala Ser Ile Gly Asp Lys Glu Lys Ile Thr His Tyr 
        755                 760                 765             


Ala Asn Gln Pro Ile Lys Asn Lys Asn Pro Asp Asn Glu Lys Lys Glu 
    770                 775                 780                 


Ser Val Phe Glu Tyr Asp Ile Val Lys Asp Lys Arg Phe Thr Lys Arg 
785                 790                 795                 800 


Gln Phe Ser Leu His Leu Pro Ile Thr Ile Asn Phe Lys Ala His Gly 
                805                 810                 815     


Gln Glu Phe Leu Asn Tyr Asp Val Arg Lys Ala Val Lys Tyr Lys Asp 
            820                 825                 830         


Asp Asn Tyr Val Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu Ile Tyr 
        835                 840                 845             


Ile Ser Val Ile Asn Ser Asn Gly Glu Ile Val Glu Gln Met Ser Leu 
    850                 855                 860                 


Asn Glu Ile Ile Ser Asp Asn Gly His Lys Val Asp Tyr Gln Lys Leu 
865                 870                 875                 880 


Leu Asp Thr Lys Glu Lys Glu Arg Asp Lys Ala Arg Lys Asn Trp Thr 
                885                 890                 895     


Ser Val Glu Asn Ile Lys Glu Leu Lys Glu Gly Tyr Ile Ser Gln Val 
            900                 905                 910         


Val His Lys Ile Cys Glu Leu Val Ile Lys Tyr Asp Ala Val Ile Ala 
        915                 920                 925             


Met Glu Asp Leu Asn Phe Gly Phe Lys Arg Gly Arg Phe Pro Val Glu 
    930                 935                 940                 


Lys Gln Val Tyr Gln Lys Phe Glu Asn Met Leu Ile Ser Lys Leu Asn 
945                 950                 955                 960 


Leu Leu Ile Asp Lys Lys Ala Glu Pro Thr Glu Asp Gly Gly Leu Leu 
                965                 970                 975     


Arg Ala Tyr Gln Leu Thr Asn Lys Phe Asp Gly Val Asn Lys Ala Lys 
            980                 985                 990         


Gln Asn Gly Ile Ile Phe Tyr Val  Pro Ala Trp Asp Thr  Ser Lys Ile 
        995                 1000                 1005             


Asp Pro  Ala Thr Gly Phe Val  Asn Leu Leu Lys Pro  Lys Cys Asn 
    1010                 1015                 1020             


Thr Ser  Val Pro Glu Ala Lys  Lys Leu Phe Glu Thr  Ile Asp Asp 
    1025                 1030                 1035             


Ile Lys  Tyr Asn Ala Asn Thr  Asp Met Phe Glu Phe  Tyr Ile Asp 
    1040                 1045                 1050             


Tyr Ser  Lys Phe Pro Arg Cys  Asn Ser Asp Phe Lys  Lys Ser Trp 
    1055                 1060                 1065             


Thr Val  Cys Thr Asn Ser Ser  Arg Ile Leu Thr Phe  Arg Asn Lys 
    1070                 1075                 1080             


Glu Lys  Asn Asn Lys Trp Asp  Asn Lys Gln Ile Val  Leu Thr Asp 
    1085                 1090                 1095             


Glu Phe  Lys Ser Leu Phe Asn  Glu Phe Gly Ile Asp  Tyr Lys Gly 
    1100                 1105                 1110             


Asn Leu  Lys Asp Ser Ile Leu  Ser Ile Ser Asn Ala  Asp Phe Tyr 
    1115                 1120                 1125             


Arg Arg  Leu Ile Lys Leu Leu  Ser Leu Thr Leu Gln  Met Arg Asn 
    1130                 1135                 1140             


Ser Ile  Thr Gly Ser Thr Leu  Pro Glu Asp Asp Tyr  Leu Ile Ser 
    1145                 1150                 1155             


Pro Val  Ala Asn Lys Ser Gly  Glu Phe Tyr Asp Ser  Arg Asn Tyr 
    1160                 1165                 1170             


Lys Gly  Thr Asn Ala Ala Leu  Pro Cys Asp Ala Asp  Ala Asn Gly 
    1175                 1180                 1185             


Ala Tyr  Asn Ile Ala Arg Lys  Ala Leu Trp Ala Ile  Asn Val Leu 
    1190                 1195                 1200             


Lys Asp  Thr Pro Asp Asp Met  Leu Asn Lys Ala Lys  Leu Ser Ile 
    1205                 1210                 1215             


Thr Asn  Ala Glu Trp Leu Glu  Tyr Thr Gln Lys 
    1220                 1225                 


<210>  15
<211>  1242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  15

Met Lys Glu Gln Phe Val Asn Gln Tyr Pro Ile Ser Lys Thr Leu Arg 
1               5                   10                  15      


Phe Ser Leu Ile Pro Ile Gly Lys Thr Glu Glu Asn Phe Asn Lys Asn 
            20                  25                  30          


Leu Leu Leu Lys Glu Asp Glu Lys Lys Ala Glu Glu Tyr Gln Lys Val 
        35                  40                  45              


Lys Gly Tyr Ile Asp Arg Tyr His Lys Phe Phe Ile Glu Thr Ala Leu 
    50                  55                  60                  


Cys Asn Ile Asn Phe Glu Gly Phe Glu Glu Tyr Ser Leu Leu Tyr Tyr 
65                  70                  75                  80  


Lys Cys Ser Lys Asp Asp Asn Asp Leu Lys Thr Met Glu Asp Ile Glu 
                85                  90                  95      


Ile Lys Leu Arg Lys Gln Ile Ser Lys Thr Met Thr Ser His Lys Leu 
            100                 105                 110         


Tyr Lys Asp Leu Phe Gly Glu Asn Met Ile Lys Thr Ile Leu Pro Asn 
        115                 120                 125             


Phe Leu Asp Ser Asp Glu Glu Lys Asn Ser Leu Glu Met Phe Arg Gly 
    130                 135                 140                 


Phe Tyr Thr Tyr Phe Ser Gly Phe Asn Thr Asn Arg Lys Asn Met Tyr 
145                 150                 155                 160 


Thr Glu Glu Ala Lys Ser Thr Ser Ile Ala Tyr Arg Cys Ile Asn Asp 
                165                 170                 175     


Asn Leu Pro Lys Phe Leu Asp Asn Ser Lys Ser Phe Glu Lys Ile Lys 
            180                 185                 190         


Cys Ala Leu Asn Lys Glu Glu Leu Lys Ala Lys Asn Glu Glu Phe Tyr 
        195                 200                 205             


Glu Ile Phe Gln Ile Tyr Ala Thr Asp Ile Phe Asn Ile Asp Phe Phe 
    210                 215                 220                 


Asn Phe Val Leu Thr Gln Pro Gly Ile Asp Lys Tyr Asn Gly Ile Ile 
225                 230                 235                 240 


Gly Gly Tyr Thr Cys Ser Asp Gly Thr Lys Val Gln Gly Leu Asn Glu 
                245                 250                 255     


Ile Ile Asn Leu Tyr Asn Gln Gln Ile Ala Lys Asp Asp Lys Ser Lys 
            260                 265                 270         


Arg Leu Pro Leu Leu Lys Met Leu Tyr Lys Gln Ile Leu Ser Asp Arg 
        275                 280                 285             


Glu Thr Val Ser Phe Ile Pro Glu Lys Phe Ser Ser Asp Asn Glu Val 
    290                 295                 300                 


Leu Glu Ser Ile Asn Asn Tyr Phe Ser Lys Asn Val Ser Asn Ala Ile 
305                 310                 315                 320 


Lys Ser Leu Lys Glu Leu Phe Gln Gly Phe Glu Ala Tyr Asn Met Asn 
                325                 330                 335     


Gly Ile Phe Ile Ser Ser Gly Val Ala Ile Thr Asp Leu Ser Asn Ala 
            340                 345                 350         


Val Phe Gly Asp Trp Asn Ala Ile Ser Thr Ala Trp Glu Lys Ala Tyr 
        355                 360                 365             


Phe Glu Thr Asn Pro Pro Lys Lys Asn Lys Ser Gln Glu Lys Tyr Glu 
    370                 375                 380                 


Glu Glu Leu Lys Ala Asn Tyr Lys Lys Ile Lys Ser Phe Ser Leu Asp 
385                 390                 395                 400 


Glu Ile Gln Arg Leu Gly Ser Ile Ala Lys Ser Pro Asp Ser Ile Gly 
                405                 410                 415     


Ser Val Ala Glu Tyr Tyr Lys Ile Thr Val Thr Glu Lys Ile Asp Asn 
            420                 425                 430         


Ile Thr Glu Leu Tyr Asp Gly Ser Lys Glu Leu Leu Asn Cys Asn Tyr 
        435                 440                 445             


Ser Glu Ser Tyr Asp Lys Lys Leu Ile Lys Asn Asp Thr Val Ile Glu 
    450                 455                 460                 


Lys Val Lys Thr Leu Leu Asp Ala Val Lys Ser Leu Glu Lys Leu Ile 
465                 470                 475                 480 


Lys Pro Leu Val Gly Thr Gly Lys Glu Asp Lys Asp Glu Leu Phe Tyr 
                485                 490                 495     


Gly Thr Phe Leu Pro Leu Tyr Thr Ser Leu Ser Ala Val Asp Arg Leu 
            500                 505                 510         


Tyr Asp Lys Val Arg Asn Tyr Ala Thr Gln Lys Pro Tyr Ser Lys Asp 
        515                 520                 525             


Lys Ile Lys Leu Asn Phe Asn Cys Ser Ser Phe Leu Ser Gly Trp Ala 
    530                 535                 540                 


Thr Asp Tyr Ser Ser Asn Gly Gly Leu Ile Phe Glu Lys Asp Gly Leu 
545                 550                 555                 560 


Tyr Tyr Leu Gly Ile Val Asn Lys Lys Phe Thr Thr Glu Glu Ile Asp 
                565                 570                 575     


Tyr Leu Gln Gln Asn Ala Asp Glu Asn Pro Ala Gln Arg Ile Val Tyr 
            580                 585                 590         


Asp Phe Gln Lys Pro Asp Asn Lys Asn Thr Pro Arg Leu Phe Ile Arg 
        595                 600                 605             


Ser Lys Gly Thr Asn Tyr Ser Pro Ser Val Lys Glu Tyr Asn Leu Pro 
    610                 615                 620                 


Val Glu Glu Ile Val Glu Leu Tyr Asp Lys Arg Tyr Phe Thr Thr Glu 
625                 630                 635                 640 


Tyr Arg Asn Lys Asn Pro Glu Leu Tyr Lys Ala Ser Leu Val Lys Leu 
                645                 650                 655     


Ile Asp Tyr Phe Lys Leu Gly Phe Thr Arg His Glu Ser Tyr Arg His 
            660                 665                 670         


Tyr Asp Phe Lys Trp Lys Lys Ser Glu Glu Tyr Asn Asp Ile Ser Glu 
        675                 680                 685             


Phe Tyr Lys Asp Val Glu Ile Ser Cys Tyr Ser Leu Lys Gln Glu Lys 
    690                 695                 700                 


Ile Asn Tyr Asn Thr Leu Leu Asn Phe Val Ala Glu Asn Arg Ile Tyr 
705                 710                 715                 720 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Lys Tyr Ser Lys Gly Thr 
                725                 730                 735     


Pro Asn Leu His Thr Arg Tyr Phe Lys Ala Leu Phe Asp Glu Asn Asn 
            740                 745                 750         


Leu Ser Asp Val Val Phe Lys Leu Asn Gly Gly Ser Glu Met Phe Phe 
        755                 760                 765             


Arg Lys Ala Ser Ile Lys Asp Asn Glu Lys Val Val His Pro Ala Asn 
    770                 775                 780                 


Gln Pro Ile Asp Asn Lys Asn Pro Asp Asn Ser Lys Lys Gln Ser Thr 
785                 790                 795                 800 


Phe Asp Tyr Glu Leu Ile Lys Asp Lys Arg Phe Thr Lys His Gln Phe 
                805                 810                 815     


Ser Ile His Ile Pro Ile Thr Met Asn Phe Lys Ala Arg Gly Arg Asp 
            820                 825                 830         


Phe Ile Asn Asn Asp Ile Arg Lys Ala Ile Lys Ser Glu Tyr Lys Pro 
        835                 840                 845             


Tyr Val Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu Ile Tyr Ile Ser 
    850                 855                 860                 


Val Ile Asn Asn Asn Gly Glu Ile Val Glu Gln Met Ser Leu Asn Asp 
865                 870                 875                 880 


Ile Ile Ser Asp Asn Gly Tyr Lys Val Asp Tyr Gln Arg Leu Leu Asp 
                885                 890                 895     


Arg Lys Glu Lys Glu Arg Asp Asn Ala Arg Lys Ser Trp Gly Thr Ile 
            900                 905                 910         


Glu Asn Ile Lys Glu Leu Lys Glu Gly Tyr Ile Ser Gln Val Ile His 
        915                 920                 925             


Lys Ile Cys Glu Leu Val Ile Lys Tyr Asp Ala Val Ile Ala Met Glu 
    930                 935                 940                 


Asp Leu Asn Phe Gly Phe Lys Arg Gly Arg Phe Asn Val Glu Lys Gln 
945                 950                 955                 960 


Val Tyr Gln Lys Phe Glu Asn Met Leu Ile Ser Lys Leu Asn Tyr Leu 
                965                 970                 975     


Cys Asp Lys Lys Ser Glu Ala Asn Ser Glu Gly Gly Leu Leu Lys Ala 
            980                 985                 990         


Tyr Gln Leu Thr Asn Lys Phe Asp  Gly Val Asn Lys Gly  Lys Gln Asn 
        995                 1000                 1005             


Gly Ile  Ile Phe Tyr Val Pro  Ala Trp Leu Thr Ser  Lys Ile Asp 
    1010                 1015                 1020             


Pro Val  Thr Gly Phe Val Asp  Leu Leu His Pro Lys  Tyr Ile Ser 
    1025                 1030                 1035             


Val Glu  Glu Thr His Ser Leu  Phe Glu Lys Leu Asp  Asp Ile Arg 
    1040                 1045                 1050             


Tyr Asn  Phe Glu Lys Asp Met  Phe Glu Phe Asp Ile  Asp Tyr Ser 
    1055                 1060                 1065             


Lys Leu  Pro Lys Cys Asn Ala  Asp Phe Lys Gln Lys  Trp Thr Val 
    1070                 1075                 1080             


Cys Thr  Asn Ala Asp Arg Ile  Met Thr Phe Arg Asn  Ser Glu Lys 
    1085                 1090                 1095             


Asn Asn  Glu Trp Asp Asn Lys  Arg Ile Leu Leu Ser  Asp Glu Phe 
    1100                 1105                 1110             


Lys Arg  Leu Phe Glu Glu Phe  Gly Ile Asp Tyr Cys  His Asn Leu 
    1115                 1120                 1125             


Lys Asn  Lys Ile Leu Ser Ile  Ser Asn Lys Asp Phe  Cys Tyr Arg 
    1130                 1135                 1140             


Phe Ile  Lys Leu Phe Ala Leu  Thr Met Gln Met Arg  Asn Ser Ile 
    1145                 1150                 1155             


Thr Gly  Ser Thr Asn Pro Glu  Asp Asp Tyr Leu Ile  Ser Pro Val 
    1160                 1165                 1170             


Arg Asp  Glu Asn Gly Val Phe  Tyr Asp Ser Arg Asn  Phe Ile Gly 
    1175                 1180                 1185             


Ser Lys  Ala Gly Leu Pro Ile  Asp Ala Asp Ala Asn  Gly Ala Tyr 
    1190                 1195                 1200             


Asn Ile  Ala Arg Lys Gly Leu  Trp Ala Ile Asn Ala  Ile Lys Ser 
    1205                 1210                 1215             


Thr Ala  Asp Asp Met Leu Asp  Lys Val Asp Leu Ser  Ile Ser Asn 
    1220                 1225                 1230             


Ala Lys  Trp Leu Glu Tyr Val  Gln Lys 
    1235                 1240         


<210>  16
<211>  1168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  16

Met Lys Ile Thr Lys Ile Asp Gly Ile Leu His Lys Lys Tyr Ile Lys 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Lys Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Thr Ile Arg Leu Asp Thr Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Thr Leu 
    50                  55                  60                  


Lys Glu Phe Phe Ser Asn Lys Val Leu Tyr Leu Lys Asp Ser Ile Leu 
65                  70                  75                  80  


Tyr Leu Lys Asp Arg Arg Glu Lys Asn Gln Leu Gln Asn Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Leu Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Asn Asp Phe Glu Lys Lys Leu Asp Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Leu Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Ile Lys Lys Val Glu Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Phe Tyr Asn Tyr Tyr Lys Asp Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Ile Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Asn Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Thr Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asn Val Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asn Lys Glu Lys Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Val Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Ser Phe Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Val Gly Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Thr Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Ile Lys Gly Lys Thr Val Lys Asn Lys 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Ile Ser Gly Glu Ile Asp Lys Leu Tyr Asp 
            420                 425                 430         


Asn Asn Lys Gln Asn Glu Val Lys Lys Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asn Arg Lys Lys Glu Ile Glu Asp Phe Phe Ser 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Thr Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Gln Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Asn Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Cys Ile Tyr Trp 
                565                 570                 575     


Lys Ile Pro Lys Ala Asn Asp Asn Asn Lys Thr Lys Glu Ile Thr Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ile Lys Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asn Leu Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Phe Tyr Met Ile Asp Ala Gly Asn Lys Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Ala Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Met 
    690                 695                 700                 


Tyr Ile Gly Asn Asp Glu Gln Ile Asn Thr Ser Leu Ala Gly Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Gln Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Val Lys Asp Asn Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Ile Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Ile Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys 
        915                 920                 925             


Lys Tyr Glu Lys Thr Ile Arg Asn Ile Gln Gln Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu 
945                 950                 955                 960 


Arg Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Asn Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Ser Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asp  Met Glu Lys Ile Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Glu Leu  Lys Lys Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  Asn Ala Glu Val Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Ile Met Lys Ser  Ile Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Val Thr Phe Lys  Ile Glu Lys Asp Lys  Lys Ile Arg 
    1100                 1105                 1110             


Ile Glu  Ser Leu Lys Ser Glu  Glu Val Val His Leu  Lys Lys Leu 
    1115                 1120                 1125             


Lys Leu  Lys Asp Asn Asp Lys  Lys Lys Glu Pro Ile  Lys Thr Tyr 
    1130                 1135                 1140             


Arg Asn  Ser Lys Glu Leu Cys  Lys Leu Val Lys Val  Met Phe Glu 
    1145                 1150                 1155             


Tyr Lys  Met Lys Glu Lys Lys  Ser Glu Asn 
    1160                 1165             


<210>  17
<211>  1168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  17

Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His Lys Lys Tyr Ile Lys 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Lys Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Thr Ile Arg Leu Asp Thr Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Glu Phe Phe Ser Asn Lys Val Leu Tyr Leu Lys Asp Gly Ile Leu 
65                  70                  75                  80  


Tyr Leu Lys Asp Arg Arg Glu Lys Asn Gln Leu Gln Asn Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Leu Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Gly Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Lys Asp Asp Ile Thr Gly Lys Met Arg Gly Lys Thr Arg Ile Asp Ser 
                405                 410                 415     


Lys Thr Gly Glu Glu Lys Tyr Ile Pro Gly Glu Val Asp Gln Ile Tyr 
            420                 425                 430         


Tyr Glu Asn Lys Gln Asn Glu Val Lys Asn Lys Leu Lys Met Phe Tyr 
        435                 440                 445             


Gly Tyr Asp Phe Asp Met Asp Asn Lys Lys Glu Ile Glu Asp Phe Phe 
    450                 455                 460                 


Ala Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His 
465                 470                 475                 480 


Phe Asn Leu Asp Leu Asp Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile 
                485                 490                 495     


Val Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu 
            500                 505                 510         


Lys Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val 
        515                 520                 525             


Phe Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr 
    530                 535                 540                 


Arg Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr 
545                 550                 555                 560 


Lys Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr 
                565                 570                 575     


Trp Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile 
            580                 585                 590         


Asp Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu 
        595                 600                 605             


Asn Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu 
    610                 615                 620                 


Ile Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe 
625                 630                 635                 640 


Tyr Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Lys 
                645                 650                 655     


Tyr Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln 
            660                 665                 670         


Asp Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe 
        675                 680                 685             


Leu Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu 
    690                 695                 700                 


Met Tyr Ile Gly Asn Asp Glu Gln Ile Asn Thr Ser Leu Ala Gly Lys 
705                 710                 715                 720 


Lys Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn 
                725                 730                 735     


Ile Glu Ile Pro His Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu 
            740                 745                 750         


Gly Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile 
        755                 760                 765             


Leu Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu 
    770                 775                 780                 


Glu Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu 
785                 790                 795                 800 


Glu Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp 
                805                 810                 815     


Phe Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly 
            820                 825                 830         


Asn Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Lys Lys 
        835                 840                 845             


Ile Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn 
    850                 855                 860                 


Ile Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys 
865                 870                 875                 880 


Ala Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys 
                885                 890                 895     


Lys Asn Glu Ile Glu Lys Asn Tyr Thr Met Gln Gln Asn Leu His Arg 
            900                 905                 910         


Lys Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr 
        915                 920                 925             


Lys Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu 
    930                 935                 940                 


Lys Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu 
945                 950                 955                 960 


Leu Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg 
                965                 970                 975     


Asp Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile 
            980                 985                 990         


Glu Glu Ile Phe Asn Phe Asp Asn  Ser Lys Asn Val Lys  Tyr Lys Ser 
        995                 1000                 1005             


Gly Gln  Ile Val Glu Lys Tyr  Ile Asn Phe Tyr Lys  Glu Leu Tyr 
    1010                 1015                 1020             


Lys Asp  Asn Val Glu Lys Arg  Ser Ile Tyr Ser Asp  Lys Lys Val 
    1025                 1030                 1035             


Lys Lys  Leu Lys Gln Glu Lys  Lys Asp Leu Tyr Ile  Arg Asn Tyr 
    1040                 1045                 1050             


Ile Ala  His Phe Asn Tyr Ile  Pro His Ala Glu Ile  Ser Leu Leu 
    1055                 1060                 1065             


Glu Val  Leu Glu Asn Leu Arg  Lys Leu Leu Ser Tyr  Asp Arg Lys 
    1070                 1075                 1080             


Leu Lys  Asn Ala Ile Met Lys  Ser Val Val Asp Ile  Leu Lys Glu 
    1085                 1090                 1095             


Tyr Gly  Phe Val Ala Thr Phe  Lys Ile Gly Ala Asp  Lys Lys Ile 
    1100                 1105                 1110             


Gly Ile  Gln Thr Leu Glu Ser  Glu Lys Ile Val His  Leu Lys Asn 
    1115                 1120                 1125             


Leu Lys  Lys Lys Lys Leu Met  Thr Asp Arg Asn Ser  Glu Glu Leu 
    1130                 1135                 1140             


Cys Lys  Leu Val Lys Val Met  Phe Glu Tyr Lys Met  Glu Glu Lys 
    1145                 1150                 1155             


Asn Leu  Lys Thr Lys Lys Cys  Lys Val Ile 
    1160                 1165             


<210>  18
<211>  1224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  18

Met Lys Lys Ile Asp Asn Phe Val Gly Cys Tyr Pro Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Ile Gly Lys Thr Gln Glu Asn Ile Glu 
            20                  25                  30          


Lys Lys Arg Leu Val Glu Glu Asp Glu Val Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Ala Val Lys Lys Leu Ile Asp Arg Tyr His Arg Glu Phe Ile Glu Gly 
    50                  55                  60                  


Val Leu Asp Asn Val Lys Leu Asp Gly Leu Glu Glu Tyr Tyr Met Leu 
65                  70                  75                  80  


Phe Asn Lys Ser Asp Arg Glu Glu Ser Asp Asn Lys Lys Ile Glu Ile 
                85                  90                  95      


Met Glu Glu Arg Phe Arg Arg Val Ile Ser Lys Ser Phe Lys Asn Asn 
            100                 105                 110         


Glu Glu Tyr Lys Lys Ile Phe Ser Lys Lys Ile Ile Glu Glu Ile Leu 
        115                 120                 125             


Pro Asn Tyr Ile Lys Asp Glu Glu Glu Lys Glu Leu Val Lys Gly Phe 
    130                 135                 140                 


Lys Gly Phe Tyr Thr Ala Phe Val Gly Tyr Ala Gln Asn Arg Glu Asn 
145                 150                 155                 160 


Met Tyr Ser Asp Glu Lys Lys Ser Thr Ala Ile Ser Tyr Arg Ile Val 
                165                 170                 175     


Asn Glu Asn Met Pro Arg Phe Ile Thr Asn Ile Lys Val Phe Glu Lys 
            180                 185                 190         


Ala Lys Ser Ile Leu Asp Val Asp Lys Ile Asn Glu Ile Asn Glu Tyr 
        195                 200                 205             


Ile Leu Asn Asn Asp Tyr Tyr Val Asp Asp Phe Phe Asn Ile Asp Phe 
    210                 215                 220                 


Phe Asn Tyr Val Leu Asn Gln Lys Gly Ile Asp Ile Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Ile Val Thr Gly Asp Gly Arg Lys Ile Gln Gly Leu Asn 
                245                 250                 255     


Glu Cys Ile Asn Leu Tyr Asn Gln Glu Asn Lys Lys Ile Arg Leu Pro 
            260                 265                 270         


Gln Phe Lys Pro Leu Tyr Lys Gln Ile Leu Ser Glu Ser Glu Ser Met 
        275                 280                 285             


Ser Phe Tyr Ile Asp Glu Ile Glu Ser Asp Asp Met Leu Ile Asp Met 
    290                 295                 300                 


Leu Lys Glu Ser Leu Gln Ile Asp Ser Thr Ile Asn Asn Ala Ile Asp 
305                 310                 315                 320 


Asp Leu Lys Val Leu Phe Asn Asn Ile Phe Asp Tyr Asp Leu Ser Gly 
                325                 330                 335     


Ile Phe Ile Asn Asn Gly Leu Pro Ile Thr Thr Ile Ser Asn Asp Val 
            340                 345                 350         


Tyr Gly Gln Trp Ser Thr Ile Ser Asp Gly Trp Asn Glu Arg Tyr Asp 
        355                 360                 365             


Val Leu Ser Asn Ala Lys Asp Lys Glu Ser Glu Lys Tyr Phe Glu Lys 
    370                 375                 380                 


Arg Arg Lys Glu Tyr Lys Lys Val Lys Ser Phe Ser Ile Ser Asp Leu 
385                 390                 395                 400 


Gln Glu Leu Gly Gly Lys Asp Leu Ser Ile Cys Lys Lys Ile Asn Glu 
                405                 410                 415     


Ile Ile Ser Glu Met Ile Asp Asp Tyr Lys Ser Lys Ile Glu Glu Ile 
            420                 425                 430         


Gln Tyr Leu Phe Asp Ile Lys Glu Leu Glu Lys Pro Leu Val Thr Asp 
        435                 440                 445             


Leu Asn Lys Ile Glu Leu Ile Lys Asn Ser Leu Asp Gly Leu Lys Arg 
    450                 455                 460                 


Ile Glu Arg Tyr Val Ile Pro Phe Leu Gly Thr Gly Lys Glu Gln Asn 
465                 470                 475                 480 


Arg Asp Glu Val Phe Tyr Gly Tyr Phe Ile Lys Cys Ile Asp Ala Ile 
                485                 490                 495     


Lys Glu Ile Asp Gly Val Tyr Asn Lys Thr Arg Asn Tyr Leu Thr Lys 
            500                 505                 510         


Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Glu Asn Pro Gln 
        515                 520                 525             


Leu Met Gly Gly Trp Asp Arg Asn Lys Glu Ser Asp Tyr Arg Ser Thr 
    530                 535                 540                 


Leu Leu Arg Lys Asn Gly Lys Tyr Tyr Val Ala Ile Ile Asp Lys Ser 
545                 550                 555                 560 


Ser Ser Asn Cys Met Met Asn Ile Glu Glu Asp Glu Asn Asp Asn Tyr 
                565                 570                 575     


Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu Pro 
            580                 585                 590         


Lys Val Phe Phe Ser Lys Lys Asn Arg Glu Tyr Phe Ala Pro Ser Lys 
        595                 600                 605             


Glu Ile Glu Arg Ile Tyr Ser Thr Gly Thr Phe Lys Lys Asp Thr Asn 
    610                 615                 620                 


Phe Val Lys Lys Asp Cys Glu Asn Leu Ile Thr Phe Tyr Lys Asp Ser 
625                 630                 635                 640 


Leu Asp Arg His Glu Asp Trp Ser Lys Ser Phe Asp Phe Ser Phe Lys 
                645                 650                 655     


Glu Ser Ser Ala Tyr Arg Asp Ile Ser Glu Phe Tyr Arg Asp Val Glu 
            660                 665                 670         


Lys Gln Gly Tyr Arg Val Ser Phe Asp Leu Leu Ser Ser Asn Ala Val 
        675                 680                 685             


Asn Thr Leu Val Glu Glu Gly Lys Leu Tyr Leu Phe Gln Leu Tyr Asn 
    690                 695                 700                 


Lys Asp Phe Ser Glu Lys Ser His Gly Ile Pro Asn Leu His Thr Met 
705                 710                 715                 720 


Tyr Phe Arg Ser Leu Phe Asp Asp Asn Asn Lys Gly Asn Ile Arg Leu 
                725                 730                 735     


Asn Gly Gly Ala Glu Met Phe Met Arg Arg Ala Ser Leu Asn Lys Gln 
            740                 745                 750         


Asp Val Thr Val His Lys Ala Asn Gln Pro Ile Lys Asn Lys Asn Leu 
        755                 760                 765             


Leu Asn Pro Lys Lys Thr Thr Thr Leu Pro Tyr Asp Val Tyr Lys Asp 
    770                 775                 780                 


Lys Arg Phe Thr Glu Asp Gln Tyr Glu Val His Ile Pro Ile Thr Met 
785                 790                 795                 800 


Asn Lys Val Pro Asn Asn Pro Tyr Lys Ile Asn His Met Val Arg Glu 
                805                 810                 815     


Gln Leu Val Lys Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp Arg Gly 
            820                 825                 830         


Glu Arg Asn Leu Ile Tyr Val Val Val Val Asp Gly Gln Gly His Ile 
        835                 840                 845             


Val Glu Gln Leu Ser Leu Asn Glu Ile Ile Asn Glu Asn Asn Gly Ile 
    850                 855                 860                 


Ser Ile Arg Thr Asp Tyr His Thr Leu Leu Asp Ala Lys Glu Arg Glu 
865                 870                 875                 880 


Arg Asp Glu Ser Arg Lys Gln Trp Lys Gln Ile Glu Asn Ile Lys Glu 
                885                 890                 895     


Leu Lys Glu Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys Glu Leu 
            900                 905                 910         


Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn Ser Gly 
        915                 920                 925             


Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln Lys Phe 
    930                 935                 940                 


Glu Lys Met Leu Ile Thr Lys Leu Asn Tyr Met Val Asp Lys Lys Lys 
945                 950                 955                 960 


Asp Tyr Asn Lys Pro Gly Gly Val Leu Asn Gly Tyr Gln Leu Thr Thr 
                965                 970                 975     


Gln Phe Glu Ser Phe Ser Lys Met Gly Thr Gln Asn Gly Ile Met Phe 
            980                 985                 990         


Tyr Ile Pro Ala Trp Leu Thr Ser  Lys Met Asp Pro Thr  Thr Gly Phe 
        995                 1000                 1005             


Val Asp  Leu Leu Lys Pro Lys  Tyr Lys Asn Lys Ala  Asp Ala Gln 
    1010                 1015                 1020             


Lys Phe  Phe Ser Gln Phe Asp  Ser Ile Arg Tyr Asp  Asn Gln Glu 
    1025                 1030                 1035             


Asp Ala  Phe Val Phe Lys Val  Asn Tyr Thr Lys Phe  Pro Arg Thr 
    1040                 1045                 1050             


Asp Ala  Asp Tyr Asn Lys Glu  Trp Glu Ile Tyr Thr  Asn Gly Glu 
    1055                 1060                 1065             


Arg Ile  Arg Val Phe Arg Asn  Pro Lys Lys Asn Asn  Glu Tyr Asp 
    1070                 1075                 1080             


Tyr Glu  Thr Val Asn Val Ser  Glu Arg Met Lys Glu  Leu Phe Asp 
    1085                 1090                 1095             


Ser Tyr  Asp Leu Leu Tyr Asp  Lys Gly Glu Leu Lys  Glu Thr Ile 
    1100                 1105                 1110             


Cys Glu  Met Glu Glu Ser Lys  Phe Phe Glu Glu Leu  Ile Lys Leu 
    1115                 1120                 1125             


Phe Arg  Leu Thr Leu Gln Met  Arg Asn Ser Ile Ser  Gly Arg Thr 
    1130                 1135                 1140             


Asp Val  Asp Tyr Leu Ile Ser  Pro Val Lys Asn Ser  Asn Gly Tyr 
    1145                 1150                 1155             


Phe Tyr  Asn Ser Asn Asp Tyr  Lys Lys Glu Gly Ala  Lys Tyr Pro 
    1160                 1165                 1170             


Lys Asp  Ala Asp Ala Asn Gly  Ala Tyr Asn Ile Ala  Arg Lys Val 
    1175                 1180                 1185             


Leu Trp  Ala Ile Glu Gln Phe  Lys Met Ala Asp Glu  Asp Lys Leu 
    1190                 1195                 1200             


Asp Lys  Thr Lys Ile Ser Ile  Lys Asn Gln Glu Trp  Leu Glu Tyr 
    1205                 1210                 1215             


Ala Gln  Thr His Cys Glu 
    1220                 


<210>  19
<211>  1225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  19

Met Lys Lys Ile Asp Ser Phe Val Asn Tyr Tyr Pro Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Ser Leu Ile Pro Val Gly Lys Thr Glu Asp Asn Phe Asn 
            20                  25                  30          


Ala Lys Leu Leu Leu Glu Glu Asp Glu Lys Arg Ala Ile Glu Tyr Glu 
        35                  40                  45              


Lys Val Lys Arg Tyr Ile Asp Arg Tyr His Lys His Phe Ile Glu Thr 
    50                  55                  60                  


Val Leu Ala Asn Phe His Leu Asp Asp Val Asn Glu Tyr Ala Glu Leu 
65                  70                  75                  80  


Tyr Tyr Lys Ala Gly Lys Asp Asp Lys Asp Leu Lys Tyr Met Glu Lys 
                85                  90                  95      


Leu Glu Gly Lys Met Arg Lys Ser Ile Ser Ala Ala Phe Thr Lys Asp 
            100                 105                 110         


Lys Lys Tyr Lys Glu Ile Phe Gly Gln Glu Ile Ile Lys Asn Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Glu Asn Glu Asp Glu Lys Glu Ser Val Lys Met Phe 
    130                 135                 140                 


Gln Gly Phe Phe Thr Tyr Phe Thr Gly Phe Asn Asp Asn Arg Lys Asn 
145                 150                 155                 160 


Met Tyr Thr His Glu Ala Gln Thr Thr Ala Ile Ser Tyr Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Pro Lys Phe Leu Asp Asn Val Gln Ser Phe Ala Lys 
            180                 185                 190         


Ile Lys Glu Ser Ile Ser Ser Asp Ile Met Asn Lys Leu Asp Glu Val 
        195                 200                 205             


Cys Met Asp Leu Tyr Gly Val Tyr Ala Gln Asp Met Phe Cys Thr Asp 
    210                 215                 220                 


Tyr Phe Ser Phe Val Leu Ser Gln Ser Gly Ile Asp Arg Tyr Asn Asn 
225                 230                 235                 240 


Ile Ile Gly Gly Tyr Val Asp Asp Lys Gly Val Lys Ile Gln Gly Ile 
                245                 250                 255     


Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Gln Val Asp Glu Lys Asn Lys 
            260                 265                 270         


Arg Leu Pro Leu Met Lys Lys Leu Tyr Lys Gln Ile Leu Ile Glu Lys 
        275                 280                 285             


Glu Ser Ile Ser Phe Ile Pro Glu Lys Phe Glu Ser Asp Asn Ile Val 
    290                 295                 300                 


Ile Asn Ala Ile Ser Asp Tyr Tyr His Asn Asn Val Glu Asn Leu Phe 
305                 310                 315                 320 


Asp Asp Phe Asn Lys Leu Phe Asn Glu Phe Ser Glu Tyr Asp Asp Asn 
                325                 330                 335     


Gly Ile Phe Val Thr Ser Gly Leu Ala Val Thr Asp Ile Ser Asn Ala 
            340                 345                 350         


Val Phe Gly Ser Trp Asn Ile Ile Ser Asp Ser Trp Asn Glu Glu Tyr 
        355                 360                 365             


Lys Asp Ser His Pro Met Lys Lys Thr Thr Asn Ala Glu Lys Tyr Tyr 
    370                 375                 380                 


Glu Asp Met Lys Lys Glu Tyr Lys Lys Asn Leu Ser Phe Thr Ile Ala 
385                 390                 395                 400 


Glu Leu Gln Arg Leu Gly Glu Ala Gly Cys Asn Asp Glu Cys Lys Gly 
                405                 410                 415     


Asp Ile Lys Glu Tyr Tyr Lys Thr Thr Val Ala Glu Lys Ile Glu Asn 
            420                 425                 430         


Ile Lys Asn Ala Tyr Glu Ile Ser Lys Asp Leu Leu Ala Ser Asp Tyr 
        435                 440                 445             


Glu Lys Ser Asn Asp Lys Lys Leu Cys Lys Asn Asp Ser Ala Ile Ser 
    450                 455                 460                 


Leu Leu Lys Asn Leu Leu Asp Ser Ile Lys Asp Leu Glu Lys Thr Ile 
465                 470                 475                 480 


Lys Pro Leu Leu Gly Thr Gly Lys Glu Glu Asn Lys Asp Asp Val Phe 
                485                 490                 495     


Tyr Gly Lys Phe Thr Asn Leu Tyr Glu Met Ile Ser Glu Ile Asp Arg 
            500                 505                 510         


Leu Tyr Asp Lys Val Arg Asn Tyr Val Thr Gln Lys Pro Tyr Ser Lys 
        515                 520                 525             


Asp Lys Ile Lys Leu Asn Phe Glu Asn Pro Gln His Leu Gly Gly Trp 
    530                 535                 540                 


Asp Lys Asn Lys Glu Arg Asp Tyr Arg Ser Val Leu Leu Lys Lys Glu 
545                 550                 555                 560 


Asp Lys Tyr Tyr Leu Ala Ile Met Asp Lys Ser Asn Asn Lys Ala Phe 
                565                 570                 575     


Ile Asp Phe Pro Asp Asp Gly Glu Cys Tyr Glu Lys Ile Glu Tyr Lys 
            580                 585                 590         


Leu Leu Pro Gly Pro Asn Lys Met Leu Pro Lys Val Phe Phe Ala Ser 
        595                 600                 605             


Ser Asn Ile Glu Tyr Phe Ala Pro Ser Lys Lys Ile Leu Glu Ile Arg 
    610                 615                 620                 


Ser Arg Glu Ser Phe Lys Lys Gly Asp Met Phe Asn Leu Lys Asp Cys 
625                 630                 635                 640 


His Glu Phe Ile Asp Phe Phe Lys Glu Ser Ile Lys Lys His Glu Asp 
                645                 650                 655     


Trp Ser Gln Phe Gly Phe Glu Phe Ser Pro Thr Glu Lys Tyr Asn Asp 
            660                 665                 670         


Ile Ser Glu Phe Tyr Asn Glu Val Lys Ile Gln Gly Tyr Ser Leu Lys 
        675                 680                 685             


Tyr Lys Asn Val Ser Lys Lys Tyr Ile Asp Glu Leu Ile Glu Cys Gly 
    690                 695                 700                 


Gln Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Val Tyr Ala 
705                 710                 715                 720 


Lys Gly Asn Pro Asn Leu His Thr Met Tyr Phe Lys Met Leu Phe Asp 
                725                 730                 735     


Glu Arg Asn Leu Ala Asn Val Val Tyr Gln Leu Asn Gly Gly Ala Glu 
            740                 745                 750         


Met Phe Tyr Arg Lys Ala Ser Ile Lys Asp Ser Glu Lys Ile Val His 
        755                 760                 765             


His Ala Asn Gln Pro Ile Lys Asn Lys Asn Ala Asp Asn Val Lys Lys 
    770                 775                 780                 


Glu Ser Val Phe Glu Tyr Asp Ile Ile Lys Asp Lys Arg Phe Thr Lys 
785                 790                 795                 800 


Arg Gln Phe Ser Ile His Ile Pro Ile Thr Leu Asn Phe Lys Ala Lys 
                805                 810                 815     


Gly Gln Asn Phe Ile Asn Asn Asp Val Arg Met Ala Leu Lys Lys Ala 
            820                 825                 830         


Asp Glu Asn Tyr Val Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu Leu 
        835                 840                 845             


Tyr Ile Cys Val Ile Asn Ser Lys Gly Glu Ile Val Glu Gln Lys Ser 
    850                 855                 860                 


Leu Asn Glu Ile Ile Gly Asp Asn Gly Tyr Arg Val Asp Tyr His Lys 
865                 870                 875                 880 


Leu Leu Asp Lys Lys Glu Ala Glu Arg Asp Glu Ala Arg Lys Ser Trp 
                885                 890                 895     


Gly Thr Ile Glu Asn Ile Lys Glu Leu Lys Glu Gly Tyr Leu Ser Gln 
            900                 905                 910         


Ile Val His Glu Ile Ser Lys Leu Val Ile Lys Tyr Asp Ala Val Ile 
        915                 920                 925             


Ala Ile Glu Asp Leu Asn Ser Gly Phe Lys Lys Gly Arg Phe Lys Val 
    930                 935                 940                 


Glu Lys Gln Val Tyr Gln Lys Phe Glu Asn Met Leu Cys Thr Lys Leu 
945                 950                 955                 960 


Asn Tyr Leu Val Asp Lys Asn Ala Asp Ala Asn Glu Cys Gly Gly Leu 
                965                 970                 975     


Leu Lys Ala Tyr Gln Leu Thr Asn Lys Glu Asp Gly Ala Asn Arg Gly 
            980                 985                 990         


Arg Gln Asn Gly Ile Ile Phe Ser  Val Pro Ala Trp Leu  Thr Ser Lys 
        995                 1000                 1005             


Ile Asp  Pro Val Thr Gly Phe  Ala Asp Leu Leu Arg  Pro Lys Tyr 
    1010                 1015                 1020             


Lys Ser  Val Ser Glu Ser Val  Glu Phe Ile Ser Lys  Ile Asp Asn 
    1025                 1030                 1035             


Ile Arg  Tyr Asn Ser Lys Glu  Asp Tyr Phe Glu Phe  Asp Ile Asp 
    1040                 1045                 1050             


Tyr Ser  Lys Phe Pro Asn Ser  Thr Ala Ser Tyr Lys  Lys Lys Trp 
    1055                 1060                 1065             


Thr Val  Cys Thr Tyr Gly Glu  Arg Ile Ile Asn Val  Arg Asn Lys 
    1070                 1075                 1080             


Glu Lys  Asn Asn Met Trp Asp  Asn Lys Thr Ile Val  Leu Thr Asp 
    1085                 1090                 1095             


Glu Phe  Lys Lys Leu Phe Ala  Asp Phe Gly Val Asp  Val Ser Lys 
    1100                 1105                 1110             


Asn Ile  Lys Glu Ser Val Leu  Ala Ile Asp Ser Lys  Asp Phe Tyr 
    1115                 1120                 1125             


Tyr Arg  Phe Ile Asn Leu Leu  Ala Asn Thr Leu Gln  Leu Arg Asn 
    1130                 1135                 1140             


Ser Glu  Val Gly Asn Val Asp  Val Asp Tyr Leu Ile  Ser Pro Val 
    1145                 1150                 1155             


Lys Gly  Val Asp Gly Ser Phe  Tyr Asp Ser Arg Leu  Val Lys Glu 
    1160                 1165                 1170             


Lys Thr  Leu Pro Glu Asn Ala  Asp Ala Asn Gly Ala  Tyr Asn Ile 
    1175                 1180                 1185             


Ala Arg  Lys Ala Leu Trp Ala  Ile Asp Val Leu Lys  Gln Thr Lys 
    1190                 1195                 1200             


Asp Glu  Glu Leu Lys Asn Ala  Asn Leu Ser Ile Lys  Asn Ala Glu 
    1205                 1210                 1215             


Trp Leu  Glu Tyr Val Gln Lys  
    1220                 1225 


<210>  20
<211>  1165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  20

Met Lys Asn Gln Asn Thr Leu Pro Ser Asn Pro Thr Asp Ile Leu Lys 
1               5                   10                  15      


Asp Lys Pro Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Leu Thr Val Asn His Ile Asn Lys Leu Leu Asp Leu Glu Lys Leu 
        35                  40                  45              


Tyr Asn Lys Asp Lys His Lys Glu Ile Phe Glu His Glu Asp Ile Phe 
    50                  55                  60                  


Asn Ile Ser Asp Asp Val Met Asn Asp Val Asn Ser Asn Gly Lys Lys 
65                  70                  75                  80  


Arg Lys Leu Asp Ile Lys Lys Ile Trp Ala Asn Leu Asp Thr Asp Leu 
                85                  90                  95      


Thr Arg Lys Tyr Gln Leu Arg Glu Leu Ile Leu Lys His Phe Pro Phe 
            100                 105                 110         


Ile Gln Pro Ala Ile Ile Gly Ala Gln Thr Lys Glu Arg Thr Thr Ile 
        115                 120                 125             


Asp Lys Asp Lys Arg Ser Thr Ser Thr Ser Asn Asp Ser Leu Lys Pro 
    130                 135                 140                 


Thr Gly Glu Gly Asp Ile Asn Asp Pro Leu Ser Leu Ser Asn Val Lys 
145                 150                 155                 160 


Ser Ile Phe Phe Arg Leu Leu Gln Met Leu Glu Gln Leu Arg Asn Tyr 
                165                 170                 175     


Tyr Ser His Val Lys His Ser Lys Ser Ala Thr Met Pro Asn Phe Asp 
            180                 185                 190         


Glu Gly Leu Leu Lys Ser Met Tyr Asn Ile Phe Ile Asp Ser Val Asn 
        195                 200                 205             


Lys Val Lys Glu Asp Tyr Ser Ser Asn Ser Val Ile Asp Pro Asn Thr 
    210                 215                 220                 


Ser Phe Ser His Leu Ile Ser Lys Asp Glu Gln Gly Glu Ile Lys Pro 
225                 230                 235                 240 


Cys Arg Tyr Ser Phe Thr Ser Lys Asp Gly Ser Ile Asn Ala Ser Gly 
                245                 250                 255     


Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Gln Asp Ser Ile Trp 
            260                 265                 270         


Met Gln Lys Lys Ile Pro Gly Phe Lys Lys Thr Ser Glu Asn Tyr Met 
        275                 280                 285             


Lys Met Thr Asn Glu Val Phe Cys Arg Asn His Ile Leu Leu Pro Lys 
    290                 295                 300                 


Met Arg Leu Glu Thr Val Tyr Asp Lys Asp Trp Met Leu Leu Asp Met 
305                 310                 315                 320 


Leu Asn Glu Val Val Arg Cys Pro Leu Ser Leu Tyr Lys Arg Leu Ala 
                325                 330                 335     


Pro Ala Asp Gln Asn Lys Phe Lys Val Pro Glu Lys Ser Ser Asp Asn 
            340                 345                 350         


Ala Asn Arg Gln Glu Asp Asp Asn Pro Phe Ser Arg Ile Leu Val Arg 
        355                 360                 365             


His Gln Asn Arg Phe Pro Tyr Phe Ala Leu Arg Phe Phe Asp Leu Asn 
    370                 375                 380                 


Glu Val Phe Thr Thr Leu Arg Phe Gln Ile Asn Leu Gly Cys Tyr His 
385                 390                 395                 400 


Phe Ala Ile Cys Lys Lys Gln Ile Gly Asp Lys Lys Glu Val His His 
                405                 410                 415     


Leu Thr Arg Thr Leu Tyr Gly Phe Ser Arg Leu Gln Asn Phe Thr Gln 
            420                 425                 430         


Asn Thr Arg Pro Glu Glu Trp Asn Thr Leu Val Lys Thr Thr Glu Pro 
        435                 440                 445             


Ser Ser Gly Asn Asp Gly Lys Thr Val Gln Gly Val Pro Leu Pro Tyr 
    450                 455                 460                 


Ile Ser Tyr Thr Ile Pro His Tyr Gln Ile Glu Asn Glu Lys Ile Gly 
465                 470                 475                 480 


Ile Lys Ile Phe Asp Gly Asp Thr Ala Val Asp Thr Asp Ile Trp Pro 
                485                 490                 495     


Ser Val Ser Thr Glu Lys Gln Leu Asn Lys Pro Asp Lys Tyr Thr Leu 
            500                 505                 510         


Thr Pro Gly Phe Lys Ala Asp Val Phe Leu Ser Val His Glu Leu Leu 
        515                 520                 525             


Pro Met Met Phe Tyr Tyr Gln Leu Leu Leu Cys Glu Gly Met Leu Lys 
    530                 535                 540                 


Thr Asp Ala Gly Asn Ala Val Glu Lys Val Leu Ile Asp Thr Arg Asn 
545                 550                 555                 560 


Ala Ile Phe Asn Leu Tyr Asp Ala Phe Val Gln Glu Lys Ile Asn Thr 
                565                 570                 575     


Ile Thr Asp Leu Glu Asn Tyr Leu Gln Asp Lys Pro Ile Leu Ile Gly 
            580                 585                 590         


His Leu Pro Lys Gln Met Ile Asp Leu Leu Lys Gly His Gln Arg Asp 
        595                 600                 605             


Met Leu Lys Ala Val Glu Gln Lys Lys Ala Met Leu Ile Lys Asp Thr 
    610                 615                 620                 


Glu Arg Arg Leu Glu Arg Leu Asn Lys Gln Pro Glu Gln Lys Pro Asn 
625                 630                 635                 640 


Val Ala Ala Lys Asn Thr Gly Thr Leu Leu Arg Asn Gly Gln Ile Ala 
                645                 650                 655     


Asp Trp Leu Val Lys Asp Met Met Arg Phe Gln Pro Val Lys Arg Asp 
            660                 665                 670         


Lys Glu Gly Asn Pro Ile Asn Cys Ser Lys Ala Asn Ser Thr Glu Tyr 
        675                 680                 685             


Gln Met Leu Gln Arg Ala Phe Ala Phe Tyr Thr Thr Asp Ser Tyr Arg 
    690                 695                 700                 


Leu Pro Arg Tyr Phe Glu Gln Leu His Leu Ile Asn Cys Asp Asn Ser 
705                 710                 715                 720 


His Leu Phe Leu Ser Arg Phe Glu Tyr Asp Lys Gln Pro Asn Leu Ile 
                725                 730                 735     


Ala Phe Tyr Ala Ala Tyr Leu Glu Ala Lys Leu Glu Phe Leu Asn Glu 
            740                 745                 750         


Leu Gln Pro Gln Asn Trp Ala Ser Asp Asn Tyr Phe Leu Leu Leu Arg 
        755                 760                 765             


Ala Pro Lys Asn Asp Arg Gln Lys Leu Ala Glu Gly Trp Lys Asn Gly 
    770                 775                 780                 


Phe Asn Leu Pro Arg Gly Leu Phe Thr Glu Lys Ile Lys Thr Trp Phe 
785                 790                 795                 800 


Asn Glu His Lys Thr Ile Val Asp Ile Ser Asp Cys Asp Ile Phe Lys 
                805                 810                 815     


Asn Arg Val Gly Gln Val Ala Arg Leu Ile Pro Val Phe Phe Asp Lys 
            820                 825                 830         


Lys Phe Lys Asp His Ser Gln Pro Phe Tyr Thr Tyr Asn Phe Asn Val 
        835                 840                 845             


Gly Asn Val Ser Lys Ile Thr Glu Ala Asn Tyr Leu Ser Lys Glu Lys 
    850                 855                 860                 


Arg Glu Asn Leu Phe Lys Ser Tyr Gln Asn Lys Phe Lys Asn Asn Ile 
865                 870                 875                 880 


Pro Ala Glu Lys Thr Lys Glu Tyr Arg Glu Tyr Lys Asn Phe Ser Ser 
                885                 890                 895     


Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys Asn Gln Asp Ile 
            900                 905                 910         


Leu Thr Trp Leu Met Cys Lys Asn Leu Phe Asp Glu Lys Ile Lys Pro 
        915                 920                 925             


Lys Lys Asp Ile Leu Glu Pro Arg Ile Ala Val Ser Tyr Ile Lys Leu 
    930                 935                 940                 


Asp Ser Leu Gln Thr Asn Thr Ser Thr Ala Gly Ser Leu Asn Ala Leu 
945                 950                 955                 960 


Ala Lys Val Val Pro Met Thr Leu Ala Ile His Ile Asp Ser Pro Lys 
                965                 970                 975     


Pro Lys Gly Lys Ala Gly Asn Asn Glu Lys Glu Asn Lys Glu Phe Thr 
            980                 985                 990         


Val Tyr Ile Lys Glu Glu Gly Thr  Lys Leu Leu Lys Trp  Gly Asn Phe 
        995                 1000                 1005             


Lys Thr  Leu Leu Ala Asp Arg  Arg Ile Lys Gly Leu  Phe Ser Tyr 
    1010                 1015                 1020             


Ile Glu  His Asp Asp Ile Asn  Leu Glu Lys Tyr Pro  Leu Thr Lys 
    1025                 1030                 1035             


Tyr Gln  Val Asp Ser Glu Leu  Asp Leu Tyr Gln Lys  Tyr Arg Ile 
    1040                 1045                 1050             


Asp Ile  Phe Lys Gln Thr Leu  Asp Leu Glu Ala Gln  Leu Leu Asp 
    1055                 1060                 1065             


Lys Tyr  Ser Asp Leu Asn Thr  Asp Asn Phe Asn Gln  Met Leu Ser 
    1070                 1075                 1080             


Gly Trp  Ser Glu Lys Glu Gly  Ile Pro Arg Asn Ile  Lys Gln Asp 
    1085                 1090                 1095             


Val Ala  Phe Leu Ile Gly Val  Arg Asn Gly Phe Ser  His Asn Gln 
    1100                 1105                 1110             


Tyr Pro  Asp Ser Lys Arg Ile  Ala Phe Ser Arg Ile  Lys Lys Phe 
    1115                 1120                 1125             


Asn Pro  Lys Thr Ser Ser Leu  Gln Glu Ser Glu Gly  Leu Asn Ile 
    1130                 1135                 1140             


Ala Lys  Gln Met Tyr Glu Glu  Ala Gln Gln Val Val  Asn Lys Ile 
    1145                 1150                 1155             


Lys Asn  Ile Glu Ser Phe Asp  
    1160                 1165 


<210>  21
<211>  1194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  21

Met Lys Val Thr Lys Ile Asp Gly Ile Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Phe Thr Gly His Phe Asn Ile Lys Asn Glu 
            20                  25                  30          


Met Lys Glu Arg Leu Glu Lys Leu Lys Glu Leu Lys Leu Ser Asn Tyr 
        35                  40                  45              


Ile Lys Asn Pro Glu Asn Val Lys Asn Lys Asp Lys Asn Lys Glu Lys 
    50                  55                  60                  


Glu Thr Lys Ser Arg Arg Glu Asn Leu Lys Lys Tyr Phe Ser Glu Ile 
65                  70                  75                  80  


Ile Leu Arg Lys Lys Glu Glu Lys Tyr Leu Leu Lys Lys Thr Arg Lys 
                85                  90                  95      


Phe Lys Asn Ile Thr Glu Glu Ile Asn Tyr Asp Asp Ile Lys Lys Arg 
            100                 105                 110         


Glu Asn Gln Gln Lys Ile Phe Asp Val Leu Lys Glu Leu Leu Glu Gln 
        115                 120                 125             


Arg Ile Asn Glu Asn Asp Lys Glu Glu Ile Leu Asn Phe Asp Ser Val 
    130                 135                 140                 


Lys Leu Lys Glu Ala Phe Glu Glu Asp Phe Ile Lys Lys Glu Leu Lys 
145                 150                 155                 160 


Ile Lys Ala Ile Glu Glu Ser Leu Glu Lys Asn Arg Ala Asp Tyr Arg 
                165                 170                 175     


Lys Asp Tyr Val Glu Leu Glu Asn Glu Lys Tyr Glu Asp Val Lys Gly 
            180                 185                 190         


Gln Asn Lys Arg Ser Leu Val Phe Glu Tyr Tyr Lys Asn Pro Glu Asn 
        195                 200                 205             


Arg Glu Lys Phe Lys Glu Asn Ile Lys Tyr Ala Phe Glu Asn Leu Tyr 
    210                 215                 220                 


Thr Glu Glu Asn Ile Lys Asn Leu Tyr Ser Glu Ile Lys Glu Ile Phe 
225                 230                 235                 240 


Glu Lys Val His Leu Lys Ser Lys Val Arg Tyr Phe Tyr Gln Asn Glu 
                245                 250                 255     


Ile Ile Gly Glu Ser Glu Phe Ser Glu Lys Asp Glu Glu Gly Ile Ser 
            260                 265                 270         


Ile Leu Tyr Lys Gln Ile Ile Asn Ser Val Glu Lys Lys Glu Lys Phe 
        275                 280                 285             


Ile Glu Phe Leu Gln Lys Val Lys Ile Lys Asp Leu Thr Arg Ser Gln 
    290                 295                 300                 


Ile Phe Tyr Lys Tyr Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn 
305                 310                 315                 320 


Ile Lys Tyr Val Phe Ser Tyr Phe Val Glu Ile Glu Val Asn Lys Leu 
                325                 330                 335     


Leu Lys Glu Asn Val Tyr Lys Thr Lys Lys Phe Asn Glu Gly Asn Lys 
            340                 345                 350         


Tyr Arg Val Lys Asn Ile Phe Asn Tyr Asp Lys Leu Lys Asn Leu Val 
        355                 360                 365             


Val Tyr Lys Leu Glu Asn Lys Leu Asn Asn Tyr Val Arg Asn Cys Gly 
    370                 375                 380                 


Lys Tyr Asn Tyr His Met Glu Asn Gly Asp Ile Ala Thr Ser Asp Ile 
385                 390                 395                 400 


Asn Met Lys Asn Arg Gln Thr Glu Ala Phe Leu Arg Ser Ile Leu Gly 
                405                 410                 415     


Val Ser Ser Phe Gly Tyr Phe Ser Leu Arg Asn Ile Leu Gly Val Asn 
            420                 425                 430         


Asp Asp Asp Phe Tyr Lys Ile Glu Lys Asp Glu Arg Lys Asn Glu Asn 
        435                 440                 445             


Phe Ile Leu Lys Lys Ala Lys Glu Asp Phe Thr Ser Lys Asn Ile Phe 
    450                 455                 460                 


Glu Lys Val Val Asp Lys Ser Phe Glu Lys Lys Gly Ile Tyr Gln Ile 
465                 470                 475                 480 


Lys Glu Asn Leu Lys Met Phe Tyr Gly Asn Ser Phe Asp Lys Val Asp 
                485                 490                 495     


Lys Asp Glu Leu Lys Lys Phe Phe Val Asn Met Leu Glu Ala Ile Thr 
            500                 505                 510         


Ser Val Arg His Arg Ile Val His Tyr Asn Ile Asn Thr Asn Ser Glu 
        515                 520                 525             


Asn Ile Phe Asp Phe Ser Asn Ile Glu Val Ser Lys Leu Leu Lys Asn 
    530                 535                 540                 


Ile Phe Glu Lys Glu Ile Asp Thr Arg Glu Leu Lys Leu Lys Ile Phe 
545                 550                 555                 560 


Arg Gln Leu Asn Ser Ala Gly Val Phe Asp Tyr Trp Glu Ser Trp Val 
                565                 570                 575     


Ile Lys Lys Tyr Leu Glu Asn Val Lys Phe Glu Phe Val Asn Lys Asn 
            580                 585                 590         


Val Pro Phe Val Pro Ser Phe Lys Lys Leu Tyr Asp Arg Ile Asp Asn 
        595                 600                 605             


Leu Lys Gly Trp Asn Ala Leu Lys Leu Gly Asn Asn Ile Asn Ile Pro 
    610                 615                 620                 


Lys Arg Lys Glu Ala Lys Asp Ser Gln Ile Tyr Leu Leu Lys Asn Ile 
625                 630                 635                 640 


Tyr Tyr Gly Glu Phe Val Glu Lys Phe Val Asn Asp Asn Lys Asn Phe 
                645                 650                 655     


Glu Lys Ile Val Lys Glu Ile Ile Glu Ile Asn Arg Gly Ala Gly Thr 
            660                 665                 670         


Asn Lys Lys Thr Gly Phe Tyr Lys Leu Glu Lys Phe Glu Thr Leu Lys 
        675                 680                 685             


Ala Asn Thr Pro Thr Lys Tyr Leu Glu Lys Leu Gln Ser Leu His Lys 
    690                 695                 700                 


Ile Ser Tyr Asp Lys Glu Lys Ile Glu Glu Asp Lys Asp Val Tyr Val 
705                 710                 715                 720 


Asp Phe Val Gln Lys Ile Phe Leu Lys Gly Phe Val Asn Tyr Leu Lys 
                725                 730                 735     


Lys Leu Asp Ser Leu Lys Ser Leu Asn Leu Leu Asn Leu Arg Lys Asp 
            740                 745                 750         


Glu Thr Ile Thr Asp Lys Lys Ser Val His Asp Glu Lys Leu Lys Leu 
        755                 760                 765             


Trp Glu Asn Ser Gly Ser Asn Leu Ser Lys Met Pro Glu Glu Ile Tyr 
    770                 775                 780                 


Glu Tyr Val Lys Lys Ile Lys Ile Ser Asn Ile Asn Tyr Asn Asp Arg 
785                 790                 795                 800 


Met Ser Ile Phe Tyr Leu Leu Leu Lys Leu Ile Asp Tyr Arg Glu Leu 
                805                 810                 815     


Thr Asn Leu Arg Gly Asn Leu Glu Lys Tyr Glu Ser Met Asn Lys Asn 
            820                 825                 830         


Lys Ile Tyr Ser Glu Glu Leu Thr Ile Ile Asn Leu Val Asn Leu Asp 
        835                 840                 845             


Asn Asn Lys Val Arg Thr Asn Phe Ser Leu Glu Ala Glu Asp Ile Gly 
    850                 855                 860                 


Lys Phe Leu Lys Ser Ser Ile Thr Ile Lys Asn Ile Ala Gln Leu Asn 
865                 870                 875                 880 


Asn Phe Ser Lys Ile Phe Ala Asp Gly Glu Asn Val Ile Lys His Arg 
                885                 890                 895     


Ser Phe Tyr Asn Ile Lys Lys Tyr Gly Ile Leu Asp Leu Leu Glu Lys 
            900                 905                 910         


Ile Val Ala Lys Ala Asp Leu Lys Ile Thr Lys Glu Glu Ile Lys Lys 
        915                 920                 925             


Tyr Glu Asn Leu Gln Asn Glu Leu Lys Arg Asn Asp Phe Tyr Lys Ile 
    930                 935                 940                 


Gln Glu Gln Ile His Arg Asn Tyr Asn Gln Lys Pro Phe Ser Ile Lys 
945                 950                 955                 960 


Lys Ile Glu Asn Lys Lys Asp Phe Glu Lys Tyr Lys Lys Val Ile Glu 
                965                 970                 975     


Lys Ile Gln Asp Tyr Thr Gln Leu Lys Asn Lys Ile Glu Phe Asn Asp 
            980                 985                 990         


Leu Asn Leu Leu Gln Ser Leu Ile  Phe Arg Ile Leu His  Arg Leu Ala 
        995                 1000                 1005             


Gly Tyr  Thr Ser Leu Trp Glu  Arg Asp Leu Gln Phe  Lys Leu Lys 
    1010                 1015                 1020             


Gly Glu  Phe Pro Glu Asp Lys  Tyr Ile Asp Glu Ile  Phe Asn Ser 
    1025                 1030                 1035             


Asp Gly  Asn Asn Asn Gln Lys  Tyr Lys His Gly Gly  Ile Ala Asp 
    1040                 1045                 1050             


Lys Tyr  Ala Asn Phe Leu Ile  Glu Lys Lys Glu Glu  Lys Ser Gly 
    1055                 1060                 1065             


Glu Ile  Leu Asn Lys Lys Gln  Arg Lys Lys Lys Ile  Lys Glu Asp 
    1070                 1075                 1080             


Leu Glu  Ile Arg Asn Tyr Ile  Ala His Phe Asn Tyr  Leu Pro Asn 
    1085                 1090                 1095             


Ala Glu  Lys Ser Ile Leu Glu  Ile Leu Glu Glu Leu  Arg Glu Leu 
    1100                 1105                 1110             


Leu Lys  His Asp Arg Lys Leu  Lys Asn Ala Val Met  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile Phe Arg Glu Tyr  Gly Phe Ile Val Glu  Phe Thr Ile 
    1130                 1135                 1140             


Ser His  Thr Lys Asn Gly Lys  Lys Ile Lys Val Cys  Ser Val Lys 
    1145                 1150                 1155             


Ser Glu  Lys Ile Lys His Leu  Lys Asn Asn Glu Leu  Ile Thr Thr 
    1160                 1165                 1170             


Arg Asn  Ser Glu Asp Leu Cys  Glu Leu Val Lys Ile  Met Leu Glu 
    1175                 1180                 1185             


His Lys  Glu Leu Gln Lys 
    1190                 


<210>  22
<211>  1159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  22

Met Lys Val Thr Lys Val Gly Gly Ile Ser His Lys Lys Tyr Thr Ser 
1               5                   10                  15      


Glu Gly Arg Leu Val Lys Ser Glu Ser Glu Glu Asn Arg Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Ala Leu Leu Asn Met Arg Leu Asp Met Tyr Ile Lys Asn 
        35                  40                  45              


Pro Ser Ser Thr Glu Thr Lys Glu Asn Gln Lys Arg Ile Gly Lys Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Met Val Tyr Leu Lys Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Leu Lys Asn Gly Lys Lys Glu Asn Ile Asp Arg Glu Tyr Ser Glu 
                85                  90                  95      


Thr Asp Ile Leu Glu Ser Asp Val Arg Asp Lys Lys Asn Phe Ala Val 
            100                 105                 110         


Leu Lys Lys Ile Tyr Leu Asn Glu Asn Val Asn Ser Glu Glu Leu Glu 
        115                 120                 125             


Val Phe Arg Asn Asp Ile Lys Lys Lys Leu Asn Lys Ile Asn Ser Leu 
    130                 135                 140                 


Lys Tyr Ser Phe Glu Lys Asn Lys Ala Asn Tyr Gln Lys Ile Asn Glu 
145                 150                 155                 160 


Asn Asn Ile Glu Lys Val Glu Gly Lys Ser Lys Arg Asn Ile Ile Tyr 
                165                 170                 175     


Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asp Ala Tyr Val Ser Asn Val 
            180                 185                 190         


Lys Glu Ala Phe Asp Lys Leu Tyr Lys Glu Glu Asp Ile Ala Lys Leu 
        195                 200                 205             


Val Leu Glu Ile Glu Asn Leu Thr Lys Leu Glu Lys Tyr Lys Ile Arg 
    210                 215                 220                 


Glu Phe Tyr His Glu Ile Ile Gly Arg Lys Asn Asp Lys Glu Asn Phe 
225                 230                 235                 240 


Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met Lys Glu 
                245                 250                 255     


Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser Gln Val 
            260                 265                 270         


Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys Asn Ile 
        275                 280                 285             


Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln Leu Leu 
    290                 295                 300                 


Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp Lys Ile 
305                 310                 315                 320 


Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu Asn Lys 
                325                 330                 335     


Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys Tyr Asn 
            340                 345                 350         


Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile Ala Arg 
        355                 360                 365             


Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val Ser Ser 
    370                 375                 380                 


Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn Glu Asn 
385                 390                 395                 400 


Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn Lys Gly 
                405                 410                 415     


Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn Glu Asn 
            420                 425                 430         


Lys Lys Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser Tyr Asp 
        435                 440                 445             


Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala Asn Ile 
    450                 455                 460                 


Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe Asn Leu 
465                 470                 475                 480 


Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala Pro Ser 
                485                 490                 495     


Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys Lys Leu 
            500                 505                 510         


Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe Arg Tyr 
        515                 520                 525             


Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg Phe Glu 
    530                 535                 540                 


Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu Tyr 
545                 550                 555                 560 


Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp Lys Thr 
                565                 570                 575     


Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp Ala Gln 
            580                 585                 590         


Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn Tyr Phe 
        595                 600                 605             


Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Lys Glu Ile Ile Glu 
    610                 615                 620                 


Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr Lys Leu 
625                 630                 635                 640 


Gln Lys Phe Glu Asp Ile Gln Glu Lys Ile Pro Lys Glu Tyr Leu Ala 
                645                 650                 655     


Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp Glu Glu 
            660                 665                 670         


Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu Lys Gly 
        675                 680                 685             


Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile Tyr Ile 
    690                 695                 700                 


Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys Gln Glu 
705                 710                 715                 720 


Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile Lys Ile 
                725                 730                 735     


Pro Tyr Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly Asn Ile 
            740                 745                 750         


Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu Lys Leu 
        755                 760                 765             


Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu Lys Tyr 
    770                 775                 780                 


Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Gln Leu Glu Leu Ile 
785                 790                 795                 800 


Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe Glu Leu 
                805                 810                 815     


Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn Lys Val 
            820                 825                 830         


Lys Asp Asn Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile Tyr Phe 
        835                 840                 845             


Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile Lys Lys 
    850                 855                 860                 


Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala Gly Tyr 
865                 870                 875                 880 


Lys Ile Ser Ile Glu Glu Leu Lys Lys Tyr Ser Asn Lys Lys Asn Glu 
                885                 890                 895     


Ile Glu Lys Asn His Lys Met Gln Glu Asn Leu His Arg Lys Tyr Ala 
            900                 905                 910         


Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Glu Ser Tyr 
        915                 920                 925             


Lys Gln Ala Ile Glu Asn Ile Glu Glu Tyr Thr His Leu Lys Asn Lys 
    930                 935                 940                 


Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu Arg Ile 
945                 950                 955                 960 


Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp Leu Arg 
                965                 970                 975     


Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu Glu Ile 
            980                 985                 990         


Phe Asn Phe Glu Asn Lys Lys Asn  Val Lys Tyr Lys Gly  Gly Gln Ile 
        995                 1000                 1005             


Val Glu  Lys Tyr Ile Lys Phe  Tyr Lys Glu Leu His  Gln Asn Asp 
    1010                 1015                 1020             


Glu Val  Lys Ile Asn Lys Tyr  Ser Ser Ala Asn Ile  Lys Val Leu 
    1025                 1030                 1035             


Lys Gln  Glu Lys Lys Asp Leu  Tyr Ile Arg Asn Tyr  Ile Ala His 
    1040                 1045                 1050             


Phe Asn  Tyr Ile Pro His Ala  Glu Ile Ser Leu Leu  Glu Val Leu 
    1055                 1060                 1065             


Glu Asn  Leu Arg Lys Leu Leu  Ser Tyr Asp Arg Lys  Leu Lys Asn 
    1070                 1075                 1080             


Ala Val  Met Lys Ser Val Val  Asp Ile Leu Lys Glu  Tyr Gly Phe 
    1085                 1090                 1095             


Val Ala  Thr Phe Lys Ile Gly  Ala Asp Lys Lys Ile  Gly Ile Gln 
    1100                 1105                 1110             


Thr Leu  Glu Ser Glu Lys Ile  Val His Leu Lys Asn  Leu Lys Lys 
    1115                 1120                 1125             


Lys Lys  Leu Met Thr Asp Arg  Asn Ser Glu Glu Leu  Cys Lys Leu 
    1130                 1135                 1140             


Val Lys  Ile Met Phe Glu Tyr  Lys Met Glu Glu Lys  Lys Ser Glu 
    1145                 1150                 1155             


Asn 
    


<210>  23
<211>  1134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  23

Met Asn Glu Leu Val Lys Asn Arg Cys Lys Gln Thr Lys Thr Ile Cys 
1               5                   10                  15      


Gln Lys Leu Ile Pro Ile Gly Lys Thr Arg Glu Thr Ile Glu Lys Tyr 
            20                  25                  30          


Asn Leu Met Glu Ile Asp Arg Lys Ile Ala Ala Asn Lys Glu Leu Met 
        35                  40                  45              


Asn Lys Leu Phe Ser Leu Ile Ala Gly Lys His Ile Asn Asp Thr Leu 
    50                  55                  60                  


Ser Lys Cys Thr Asp Leu Asp Phe Glu Pro Leu Leu Thr Ser Leu Ser 
65                  70                  75                  80  


Ser Leu Asn Asn Ala Lys Glu Asn Asp Arg Asp Asn Leu Arg Glu Tyr 
                85                  90                  95      


Tyr Asp Ser Val Phe Glu Glu Lys Lys Thr Leu Ala Glu Glu Ile Ser 
            100                 105                 110         


Ser Arg Leu Thr Ala Val Lys Phe Ala Gly Lys Asp Phe Phe Thr Lys 
        115                 120                 125             


Asn Ile Pro Asp Phe Leu Glu Thr Tyr Glu Gly Asp Asp Lys Asn Glu 
    130                 135                 140                 


Met Ser Glu Leu Val Ser Leu Val Ile Glu Asn Thr Val Thr Ala Gly 
145                 150                 155                 160 


Tyr Val Lys Lys Leu Glu Lys Ile Asp Arg Ser Met Glu Tyr Arg Leu 
                165                 170                 175     


Val Ser Gly Thr Val Val Lys Arg Val Leu Thr Asp Asn Ala Asp Ile 
            180                 185                 190         


Tyr Glu Lys Asn Ile Glu Lys Ala Lys Asp Phe Asp Tyr Gly Val Leu 
        195                 200                 205             


Asn Ile Asp Glu Ala Ser Gln Phe Thr Thr Leu Val Ala Lys Asp Tyr 
    210                 215                 220                 


Ala Asn Tyr Leu Thr Ala Asp Gly Ile Ala Ile Tyr Asn Val Gly Ile 
225                 230                 235                 240 


Gly Lys Ile Asn Leu Ala Leu Asn Glu Tyr Cys Gln Lys Asn Lys Glu 
                245                 250                 255     


Tyr Ser Tyr Asn Lys Leu Ala Leu Leu Pro Leu Gln Lys Met Leu Tyr 
            260                 265                 270         


Gly Glu Lys Leu Ser Leu Phe Glu Lys Leu Glu Asp Phe Thr Ser Asp 
        275                 280                 285             


Glu Glu Leu Ile Asn Ser Tyr Asn Lys Phe Ala Lys Thr Val Asn Glu 
    290                 295                 300                 


Ser Gly Leu Ala Glu Ile Ile Lys Lys Ala Val Pro Ser Tyr Asp Glu 
305                 310                 315                 320 


Ile Val Ile Lys Pro Asn Lys Ile Ser Asn Tyr Ser Asn Ser Ile Thr 
                325                 330                 335     


Gly His Trp Ser Leu Val Asn Arg Ile Met Lys Asp Tyr Leu Glu Asn 
            340                 345                 350         


Asn Gly Ile Lys Asn Ala Asp Lys Tyr Met Glu Lys Gly Leu Thr Leu 
        355                 360                 365             


Ser Glu Ile Gly Asp Ala Leu Glu Asn Lys Asn Ile Lys His Ser Asp 
    370                 375                 380                 


Phe Ile Ser Asn Leu Ile Asn Asp Leu Gly His Thr Tyr Thr Glu Ile 
385                 390                 395                 400 


Lys Glu Asn Lys Glu Ser Leu Lys Lys Asp Glu Ser Val Asn Ala Leu 
                405                 410                 415     


Ile Ile Lys Lys Glu Leu Asp Met Leu Leu Ser Ile Leu Gln Asn Leu 
            420                 425                 430         


Lys Val Phe Asp Ile Asp Asn Glu Met Phe Asp Thr Gly Phe Gly Ile 
        435                 440                 445             


Glu Val Ser Lys Ala Ile Glu Ile Leu Gly Tyr Gly Val Pro Leu Tyr 
    450                 455                 460                 


Asn Lys Ile Arg Asn Tyr Ile Thr Lys Lys Pro Asp Pro Lys Lys Lys 
465                 470                 475                 480 


Phe Met Thr Lys Phe Gly Ser Ala Thr Ile Gly Thr Gly Ile Thr Thr 
                485                 490                 495     


Ser Val Glu Gly Ser Lys Lys Ala Thr Phe Leu Lys Asp Gly Asp Ala 
            500                 505                 510         


Val Phe Leu Leu Leu Tyr Asn Thr Ala Gly Cys Lys Ala Asn Asn Val 
        515                 520                 525             


Ser Val Ser Asn Leu Ala Asp Leu Ile Asn Ser Ser Leu Glu Ile Glu 
    530                 535                 540                 


Asn Ser Gly Lys Cys Tyr Gln Lys Met Ile Tyr Gln Thr Pro Gly Asp 
545                 550                 555                 560 


Ile Lys Lys Gln Ile Pro Arg Val Phe Val Tyr Lys Ser Glu Asp Asp 
                565                 570                 575     


Asp Leu Ile Lys Asp Phe Lys Ala Gly Leu His Lys Thr Asp Leu Ser 
            580                 585                 590         


Phe Leu Asn Gly Arg Leu Ile Pro Tyr Leu Lys Glu Ala Phe Ala Thr 
        595                 600                 605             


His Glu Thr Tyr Lys Asn Tyr Thr Phe Ser Tyr Arg Asn Ser Tyr Glu 
    610                 615                 620                 


Ser Tyr Asp Glu Phe Cys Glu His Met Ser Glu Gln Ala Tyr Ile Leu 
625                 630                 635                 640 


Glu Trp Lys Trp Ile Asp Lys Lys Leu Ile Asp Asp Leu Val Glu Asp 
                645                 650                 655     


Gly Ser Leu Leu Met Phe Arg Val Trp Asn Arg Phe Met Lys Lys Lys 
            660                 665                 670         


Glu Gly Lys Ile Ser Lys His Ala Lys Ile Val Asn Glu Leu Phe Ser 
        675                 680                 685             


Asp Glu Asn Ala Ser Asn Ala Ala Ile Lys Leu Leu Ser Val Phe Asp 
    690                 695                 700                 


Ile Phe Tyr Arg Asp Lys Gln Ile Asp Asn Pro Ile Val His Lys Ala 
705                 710                 715                 720 


Gly Thr Thr Leu Tyr Asn Lys Arg Thr Lys Asp Gly Glu Val Ile Val 
                725                 730                 735     


Asp Tyr Thr Thr Met Val Lys Asn Lys Glu Lys Arg Pro Asn Val Tyr 
            740                 745                 750         


Thr Thr Thr Lys Lys Tyr Asp Ile Ile Lys Asp Arg Arg Tyr Thr Glu 
        755                 760                 765             


Glu Gln Phe Glu Ile His Leu His Val Asn Ile Gly Lys Glu Glu Asn 
    770                 775                 780                 


Lys Glu Lys Leu Glu Thr Ser Lys Val Ile Asn Glu Lys Lys Asn Thr 
785                 790                 795                 800 


Leu Val Val Thr Arg Ser Asn Glu His Leu Leu Tyr Val Val Ile Phe 
                805                 810                 815     


Asp Glu Asn Asp Asn Ile Leu Leu Lys Lys Ser Leu Asn Thr Val Lys 
            820                 825                 830         


Gly Met Asn Phe Lys Ser Lys Leu Glu Val Val Glu Ile Gln Lys Lys 
        835                 840                 845             


Glu Asn Met Gln Ser Trp Lys Thr Val Gly Ser Asn Gln Ala Leu Met 
    850                 855                 860                 


Glu Gly Tyr Leu Ser Phe Ala Ile Lys Glu Ile Ala Asp Leu Val Lys 
865                 870                 875                 880 


Glu Tyr Asp Ala Ile Leu Val Leu Glu Gln Asn Ser Val Gly Lys Asn 
                885                 890                 895     


Ile Leu Asn Glu Arg Val Tyr Thr Arg Phe Lys Glu Met Leu Ile Thr 
            900                 905                 910         


Asn Leu Ser Leu Asp Val Asp Tyr Glu Asn Lys Asp Phe Tyr Ser Tyr 
        915                 920                 925             


Thr Glu Leu Gly Gly Lys Val Ala Ser Trp Arg Asp Cys Val Thr Asn 
    930                 935                 940                 


Gly Ile Cys Ile Gln Val Pro Ser Ala Tyr Lys Tyr Lys Asp Pro Thr 
945                 950                 955                 960 


Thr Ser Phe Ser Thr Ile Ser Met Tyr Ala Lys Thr Thr Ala Glu Lys 
                965                 970                 975     


Ser Lys Lys Leu Lys Gln Ile Lys Ser Phe Lys Tyr Asn Arg Glu Arg 
            980                 985                 990         


Gly Leu Phe Glu Leu Val Ile Ala  Lys Gly Val Gly Leu  Glu Asn Asn 
        995                 1000                 1005             


Ile Val  Cys Asp Ser Phe Gly  Ser Arg Ser Ile Ile  Glu Asn Asp 
    1010                 1015                 1020             


Ile Ser  Lys Glu Val Ser Cys  Thr Leu Lys Ile Glu  Lys Tyr Leu 
    1025                 1030                 1035             


Ile Asp  Ala Gly Ile Glu Tyr  Asn Asp Glu Lys Glu  Val Leu Lys 
    1040                 1045                 1050             


Asp Leu  Asp Thr Ala Ala Lys  Thr Asp Ala Val His  Lys Ala Val 
    1055                 1060                 1065             


Thr Leu  Leu Leu Lys Cys Phe  Asn Glu Ser Pro Asp  Gly Arg Tyr 
    1070                 1075                 1080             


Tyr Ile  Ser Pro Cys Gly Glu  His Phe Thr Leu Cys  Asp Ala Pro 
    1085                 1090                 1095             


Glu Val  Leu Ser Ala Ile Asn  Tyr Tyr Ile Arg Ser  Arg Tyr Ile 
    1100                 1105                 1110             


Arg Glu  Gln Ile Val Glu Gly  Val Lys Lys Met Glu  Tyr Lys Lys 
    1115                 1120                 1125             


Thr Ile  Leu Leu Ala Lys 
    1130                 


<210>  24
<211>  1282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  24

Met Asn Gly Asn Arg Ile Ile Val Tyr Arg Glu Phe Val Gly Val Thr 
1               5                   10                  15      


Pro Val Ala Lys Thr Leu Arg Asn Glu Leu Arg Pro Ile Gly His Thr 
            20                  25                  30          


Gln Glu His Ile Ile His Asn Gly Leu Ile Gln Glu Asp Glu Leu Arg 
        35                  40                  45              


Gln Glu Lys Ser Thr Glu Leu Lys Asn Ile Met Asp Asp Tyr Tyr Arg 
    50                  55                  60                  


Glu Tyr Ile Asp Lys Ser Leu Ser Gly Val Thr Asp Leu Asp Phe Thr 
65                  70                  75                  80  


Leu Leu Phe Glu Leu Met Asn Leu Val Gln Ser Ser Pro Ser Lys Asp 
                85                  90                  95      


Asn Lys Lys Ala Leu Glu Lys Glu Gln Ser Lys Met Arg Glu Gln Ile 
            100                 105                 110         


Cys Thr His Met Gln Ser Asp Ser Asn Tyr Lys Asn Ile Phe Asn Ala 
        115                 120                 125             


Lys Phe Leu Lys Glu Ile Leu Pro Asp Phe Ile Lys Asn Tyr Asn Gln 
    130                 135                 140                 


Tyr Asp Ala Lys Asp Lys Ala Gly Lys Leu Glu Thr Leu Ala Leu Phe 
145                 150                 155                 160 


Asn Gly Phe Ser Thr Tyr Phe Thr Asp Phe Phe Glu Lys Arg Lys Asn 
                165                 170                 175     


Val Phe Thr Lys Glu Ala Val Ser Thr Ser Ile Ala Tyr Arg Ile Val 
            180                 185                 190         


His Glu Asn Ser Leu Thr Phe Leu Ala Asn Met Thr Ser Tyr Lys Lys 
        195                 200                 205             


Ile Ser Glu Lys Ala Leu Asp Glu Ile Glu Val Ile Glu Lys Asn Asn 
    210                 215                 220                 


Gln Asp Lys Met Gly Asp Trp Glu Leu Asn Gln Ile Phe Asn Pro Asp 
225                 230                 235                 240 


Phe Tyr Asn Met Val Leu Ile Gln Ser Gly Ile Asp Phe Tyr Asn Glu 
                245                 250                 255     


Ile Cys Gly Val Val Asn Ala His Met Asn Leu Tyr Cys Gln Gln Thr 
            260                 265                 270         


Lys Asn Asn Tyr Asn Leu Phe Lys Met Arg Lys Leu His Lys Gln Ile 
        275                 280                 285             


Leu Ala Tyr Thr Ser Thr Ser Phe Glu Val Pro Lys Met Phe Glu Asp 
    290                 295                 300                 


Asp Met Ser Val Tyr Asn Ala Val Asn Ala Phe Ile Asp Glu Thr Glu 
305                 310                 315                 320 


Lys Gly Asn Ile Ile Gly Lys Leu Lys Asp Ile Val Asn Lys Tyr Asp 
                325                 330                 335     


Glu Leu Asp Glu Lys Arg Ile Tyr Ile Ser Lys Asp Phe Tyr Glu Thr 
            340                 345                 350         


Leu Ser Cys Phe Met Ser Gly Asn Trp Asn Leu Ile Thr Gly Cys Val 
        355                 360                 365             


Glu Asn Phe Tyr Asp Glu Asn Ile His Ala Lys Gly Lys Ser Lys Glu 
    370                 375                 380                 


Glu Lys Val Lys Lys Ala Val Lys Glu Asp Lys Tyr Lys Ser Ile Asn 
385                 390                 395                 400 


Asp Val Asn Asp Leu Val Glu Lys Tyr Ile Asp Glu Lys Glu Arg Asn 
                405                 410                 415     


Glu Phe Lys Asn Ser Asn Ala Lys Gln Tyr Ile Arg Glu Ile Ser Asn 
            420                 425                 430         


Ile Ile Thr Asp Thr Glu Thr Ala His Leu Glu Tyr Asp Glu His Ile 
        435                 440                 445             


Ser Leu Ile Glu Ser Glu Glu Lys Ala Asp Glu Met Lys Lys Arg Leu 
    450                 455                 460                 


Asp Met Tyr Met Asn Met Tyr His Trp Ala Lys Ala Phe Ile Val Asp 
465                 470                 475                 480 


Glu Val Leu Asp Arg Asp Glu Met Phe Tyr Ser Asp Ile Asp Asp Ile 
                485                 490                 495     


Tyr Asn Ile Leu Glu Asn Ile Val Pro Leu Tyr Asn Arg Val Arg Asn 
            500                 505                 510         


Tyr Val Thr Gln Lys Pro Tyr Asn Ser Lys Lys Ile Lys Leu Asn Phe 
        515                 520                 525             


Gln Ser Pro Thr Leu Ala Asn Gly Trp Ser Gln Ser Lys Glu Phe Asp 
    530                 535                 540                 


Asn Asn Ala Ile Ile Leu Ile Arg Asp Asn Lys Tyr Tyr Leu Ala Ile 
545                 550                 555                 560 


Phe Asn Ala Lys Asn Lys Pro Asp Lys Lys Ile Ile Gln Gly Asn Ser 
                565                 570                 575     


Asp Lys Lys Asn Asp Asn Asp Tyr Lys Lys Met Val Tyr Asn Leu Leu 
            580                 585                 590         


Pro Gly Ala Asn Lys Met Leu Pro Lys Val Phe Leu Ser Lys Lys Gly 
        595                 600                 605             


Ile Glu Thr Phe Lys Pro Ser Asp Tyr Ile Ile Ser Gly Tyr Asn Ala 
    610                 615                 620                 


His Lys His Ile Lys Thr Ser Glu Asn Phe Asp Ile Ser Phe Cys Arg 
625                 630                 635                 640 


Asp Leu Ile Asp Tyr Phe Lys Asn Ser Ile Glu Lys His Ala Glu Trp 
                645                 650                 655     


Arg Lys Tyr Glu Phe Lys Phe Ser Ala Thr Asp Ser Tyr Asn Asp Ile 
            660                 665                 670         


Ser Glu Phe Tyr Arg Glu Val Glu Met Gln Gly Tyr Arg Ile Asp Trp 
        675                 680                 685             


Thr Tyr Ile Ser Glu Ala Asp Ile Asn Lys Leu Asp Glu Glu Gly Lys 
    690                 695                 700                 


Ile Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Glu Asn Ser Thr 
705                 710                 715                 720 


Gly Lys Glu Asn Leu His Thr Met Tyr Phe Lys Asn Ile Phe Ser Glu 
                725                 730                 735     


Glu Asn Leu Lys Asp Ile Ile Ile Lys Leu Asn Gly Gln Ala Glu Leu 
            740                 745                 750         


Phe Tyr Arg Arg Ala Ser Val Lys Asn Pro Val Lys His Lys Lys Asp 
        755                 760                 765             


Ser Val Leu Val Asn Lys Thr Tyr Lys Asn Gln Leu Asp Asn Gly Asp 
    770                 775                 780                 


Val Val Arg Ile Pro Ile Pro Asp Asp Ile Tyr Asn Glu Ile Tyr Lys 
785                 790                 795                 800 


Met Tyr Asn Gly Tyr Ile Lys Glu Asn Asp Leu Ser Glu Ala Ala Lys 
                805                 810                 815     


Glu Tyr Leu Asp Lys Val Glu Val Arg Thr Ala Gln Lys Asp Ile Val 
            820                 825                 830         


Lys Asp Tyr Arg Tyr Thr Val Asp Lys Tyr Phe Ile His Thr Pro Ile 
        835                 840                 845             


Thr Ile Asn Tyr Lys Val Thr Ala Arg Asn Asn Val Asn Asp Met Ala 
    850                 855                 860                 


Val Lys Tyr Ile Ala Gln Asn Asp Asp Ile His Val Ile Gly Ile Asp 
865                 870                 875                 880 


Arg Gly Glu Arg Asn Leu Ile Tyr Ile Ser Val Ile Asp Ser His Gly 
                885                 890                 895     


Asn Ile Val Lys Gln Lys Ser Tyr Asn Ile Leu Asn Asn Tyr Asp Tyr 
            900                 905                 910         


Lys Lys Lys Leu Val Glu Lys Glu Lys Thr Arg Glu Tyr Ala Arg Lys 
        915                 920                 925             


Asn Trp Lys Ser Ile Gly Asn Ile Lys Glu Leu Lys Glu Gly Tyr Ile 
    930                 935                 940                 


Ser Gly Val Val His Glu Ile Ala Met Leu Met Val Glu Tyr Asn Ala 
945                 950                 955                 960 


Ile Ile Ala Met Glu Asp Leu Asn Tyr Gly Phe Lys Arg Gly Arg Phe 
                965                 970                 975     


Lys Val Glu Arg Gln Val Tyr Gln Lys Phe Glu Ser Met Leu Ile Asn 
            980                 985                 990         


Lys Leu Asn Tyr Phe Ala Ser Lys  Gly Lys Ser Val Asp  Glu Pro Gly 
        995                 1000                 1005             


Gly Leu  Leu Lys Gly Tyr Gln  Leu Thr Tyr Val Pro  Asp Asn Ile 
    1010                 1015                 1020             


Lys Asn  Leu Gly Lys Gln Cys  Gly Val Ile Phe Tyr  Val Pro Ala 
    1025                 1030                 1035             


Ala Phe  Thr Ser Lys Ile Asp  Pro Ser Thr Gly Phe  Ile Ser Ala 
    1040                 1045                 1050             


Phe Asn  Phe Lys Ser Ile Ser  Thr Asn Ala Ser Arg  Lys Gln Phe 
    1055                 1060                 1065             


Phe Met  Gln Phe Asp Glu Ile  Arg Tyr Cys Ala Glu  Lys Asp Met 
    1070                 1075                 1080             


Phe Ser  Phe Gly Phe Asp Tyr  Asn Asn Phe Asp Thr  Tyr Asn Ile 
    1085                 1090                 1095             


Thr Met  Ser Lys Thr Gln Trp  Thr Val Tyr Thr Asn  Gly Glu Arg 
    1100                 1105                 1110             


Leu Gln  Ser Glu Phe Asn Asn  Ala Arg Arg Thr Gly  Lys Thr Lys 
    1115                 1120                 1125             


Ser Ile  Asn Leu Thr Glu Thr  Ile Lys Leu Leu Leu  Glu Asp Asn 
    1130                 1135                 1140             


Glu Ile  Asn Tyr Ala Asp Gly  His Asp Val Arg Ile  Asp Met Glu 
    1145                 1150                 1155             


Lys Met  Asp Glu Asp Lys Asn  Ser Glu Phe Phe Ala  Gln Leu Leu 
    1160                 1165                 1170             


Ser Leu  Tyr Lys Leu Thr Val  Gln Met Arg Asn Ser  Tyr Thr Glu 
    1175                 1180                 1185             


Ala Glu  Glu Gln Glu Lys Gly  Ile Ser Tyr Asp Lys  Ile Ile Ser 
    1190                 1195                 1200             


Pro Val  Ile Asn Asp Glu Gly  Glu Phe Phe Asp Ser  Asp Asn Tyr 
    1205                 1210                 1215             


Lys Glu  Ser Asp Asp Lys Glu  Cys Lys Met Pro Lys  Asp Ala Asp 
    1220                 1225                 1230             


Ala Asn  Gly Ala Tyr Cys Ile  Ala Leu Lys Gly Leu  Tyr Glu Val 
    1235                 1240                 1245             


Leu Lys  Ile Lys Ser Glu Trp  Thr Glu Asp Gly Phe  Asp Arg Asn 
    1250                 1255                 1260             


Cys Leu  Lys Leu Pro His Ala  Glu Trp Leu Asp Phe  Ile Gln Asn 
    1265                 1270                 1275             


Lys Arg  Tyr Glu 
    1280         


<210>  25
<211>  1399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  25

Met Asn Lys Asp Ile Arg Lys Asn Phe Thr Asp Phe Val Gly Ile Ser 
1               5                   10                  15      


Glu Ile Gln Lys Thr Leu Arg Phe Ile Leu Ile Pro Ile Gly Lys Thr 
            20                  25                  30          


Ala Gln Asn Ile Asp Lys Tyr Asn Met Phe Glu Asp Asp Glu Ile Arg 
        35                  40                  45              


His Glu Tyr Tyr Pro Ile Leu Lys Glu Ala Cys Asp Asp Phe Tyr Arg 
    50                  55                  60                  


Asn His Ile Asp Gln Gln Phe Glu Asn Leu Glu Leu Asp Trp Ser Lys 
65                  70                  75                  80  


Leu Asp Glu Ala Leu Ala Ser Glu Asp Arg Asp Leu Ile Asn Glu Thr 
                85                  90                  95      


Arg Ala Thr Tyr Arg Gln Val Leu Phe Asn Arg Leu Lys Asn Ser Val 
            100                 105                 110         


Asp Ile Lys Gly Asp Ser Lys Lys Asn Lys Thr Leu Ser Leu Glu Ser 
        115                 120                 125             


Ser Asp Lys Asn Leu Gly Lys Lys Lys Thr Lys Asn Thr Phe Gln Tyr 
    130                 135                 140                 


Asn Phe Asn Asp Leu Phe Lys Ala Lys Leu Ile Lys Ala Ile Leu Pro 
145                 150                 155                 160 


Leu Tyr Ile Glu Tyr Ile Tyr Glu Gly Glu Lys Leu Glu Asn Ala Lys 
                165                 170                 175     


Lys Ala Leu Lys Met Tyr Asn Arg Phe Thr Ser Arg Leu Ser Asn Phe 
            180                 185                 190         


Trp Gln Ala Arg Ala Asn Ile Phe Thr Asp Asp Glu Ile Ser Thr Gly 
        195                 200                 205             


Ser Pro Tyr Arg Leu Val Asn Asp Asn Phe Thr Ile Phe Arg Ile Asn 
    210                 215                 220                 


Asn Ser Ile Tyr Thr Lys Asn Lys Pro Phe Ile Glu Glu Asp Ile Leu 
225                 230                 235                 240 


Glu Phe Glu Lys Lys Leu Lys Ser Lys Lys Ile Ile Lys Asp Phe Glu 
                245                 250                 255     


Ser Val Asp Asp Tyr Phe Thr Val Asn Ala Phe Asn Lys Leu Cys Thr 
            260                 265                 270         


Gln Asn Gly Ile Asp Lys Tyr Asn Ser Ile Leu Gly Gly Phe Thr Thr 
        275                 280                 285             


Lys Glu Arg Glu Lys Val Lys Gly Leu Asn Glu Leu Phe Asn Leu Ala 
    290                 295                 300                 


Gln Gln Ser Ile Asn Lys Gly Lys Lys Gly Glu Tyr Arg Lys Asn Ile 
305                 310                 315                 320 


Arg Leu Gly Lys Leu Thr Lys Leu Lys Lys Gln Ile Leu Ala Ile Ser 
                325                 330                 335     


Asp Ser Thr Ser Phe Leu Ile Glu Gln Ile Glu Asp Asp Gln Asp Leu 
            340                 345                 350         


Tyr Asn Lys Ile Lys Asp Phe Phe Glu Leu Leu Leu Lys Glu Glu Ile 
        355                 360                 365             


Glu Asn Glu Asn Ile Phe Thr Gln Tyr Ala Asn Leu Gln Lys Leu Ile 
    370                 375                 380                 


Glu Gln Ala Asp Leu Ser Lys Ile Tyr Ile Asn Ala Lys His Leu Asn 
385                 390                 395                 400 


Lys Ile Ser His Gln Val Thr Gly Lys Trp Asp Ser Leu Asn Lys Gly 
                405                 410                 415     


Ile Ala Leu Leu Leu Glu Asn Ile Asn Ile Asn Glu Glu Ser Lys Glu 
            420                 425                 430         


Lys Ser Glu Val Ile Ser Asn Gly Gln Thr Lys Asp Ile Ser Ser Glu 
        435                 440                 445             


Ala Tyr Lys Arg Tyr Leu Gln Ile Gln Ser Glu Glu Lys Asp Ile Glu 
    450                 455                 460                 


Arg Leu Arg Thr Gln Ile Tyr Phe Ser Leu Glu Asp Leu Glu Lys Ala 
465                 470                 475                 480 


Leu Asp Leu Val Leu Ile Asp Glu Asn Met Asp Arg Ser Asp Lys Ser 
                485                 490                 495     


Ile Leu Ser Tyr Val Gln Ser Pro Asp Leu Asn Val Asn Phe Glu Arg 
            500                 505                 510         


Asp Leu Thr Asp Leu Tyr Ser Arg Ile Met Lys Leu Glu Glu Asn Asn 
        515                 520                 525             


Glu Lys Leu Leu Ala Asn His Ser Ala Ile Asp Leu Ile Lys Glu Phe 
    530                 535                 540                 


Leu Asp Leu Ile Met Leu Arg Tyr Ser Arg Trp Gln Ile Leu Phe Cys 
545                 550                 555                 560 


Asp Ser Asn Tyr Glu Leu Asp Gln Thr Phe Tyr Pro Ile Tyr Asp Ala 
                565                 570                 575     


Val Met Glu Ile Leu Ser Asn Ile Ile Arg Leu Tyr Asn Leu Ala Arg 
            580                 585                 590         


Asn Tyr Leu Ser Arg Lys Pro Asp Arg Met Lys Lys Lys Lys Ile Asn 
        595                 600                 605             


Phe Asn Asn Pro Thr Leu Ala Asp Gly Trp Ser Glu Ser Lys Ile Pro 
    610                 615                 620                 


Asp Asn Ser Ser Met Leu Phe Ile Lys Asp Gly Met Tyr Tyr Leu Gly 
625                 630                 635                 640 


Ile Ile Lys Asn Arg Ala Ala Tyr Ser Glu Leu Leu Glu Ala Glu Ser 
                645                 650                 655     


Leu Gln Ser Ser Glu Lys Lys Lys Ser Glu Asn Ser Ser Tyr Glu Arg 
            660                 665                 670         


Met Asn Tyr His Phe Leu Pro Asp Ala Phe Arg Ser Ile Pro Lys Ser 
        675                 680                 685             


Ser Ile Ala Met Lys Ala Val Lys Glu His Phe Glu Ile Asn Gln Lys 
    690                 695                 700                 


Thr Ala Asp Leu Leu Leu Asp Thr Asp Lys Phe Ser Lys Pro Leu Arg 
705                 710                 715                 720 


Ile Thr Lys Glu Ile Phe Asp Met Gln Tyr Val Asp Leu His Lys Asn 
                725                 730                 735     


Lys Lys Lys Tyr Gln Val Asp Tyr Leu Arg Asp Thr Gly Asp Lys Lys 
            740                 745                 750         


Gly Tyr Arg Lys Ala Leu Asn Thr Trp Leu Asn Phe Cys Lys Asp Phe 
        755                 760                 765             


Ile Ser Lys Tyr Lys Gly Arg Asn Leu Phe Asp Tyr Ser Lys Ile Lys 
    770                 775                 780                 


Asp Ala Asp His Tyr Glu Thr Val Asn Glu Phe Tyr Asn Asp Val Asp 
785                 790                 795                 800 


Lys Tyr Ser Tyr His Ile Phe Phe Thr Ser Val Ala Glu Thr Thr Val 
                805                 810                 815     


Glu Lys Phe Ile Ser Glu Gly Lys Leu Tyr Leu Phe Gln Leu Tyr Asn 
            820                 825                 830         


Lys Asp Phe Ser Pro His Ser Thr Gly Lys Pro Asn Leu His Thr Ile 
        835                 840                 845             


Tyr Trp Arg Ala Leu Phe Ser Glu Glu Asn Leu Thr Ser Lys Asn Ile 
    850                 855                 860                 


Lys Leu Asn Gly Gln Ala Glu Ile Phe Phe Arg Pro Lys Gln Ile Glu 
865                 870                 875                 880 


Thr Pro Phe Thr His Lys Lys Gly Ser Ile Leu Val Asn Arg Phe Asp 
                885                 890                 895     


Val Asn Gly Asn Pro Ile Pro Ile Asn Val Tyr Gln Glu Ile Lys Gly 
            900                 905                 910         


Phe Lys Asn Asn Val Ile Lys Trp Asp Asp Leu Asn Lys Thr Thr Gln 
        915                 920                 925             


Glu Gly Leu Glu Asn Asp Gln Tyr Leu Tyr Phe Glu Ser Glu Phe Glu 
    930                 935                 940                 


Ile Ile Lys Asp Arg Arg Tyr Thr Glu Asp Gln Leu Phe Phe His Val 
945                 950                 955                 960 


Pro Ile Ser Phe Asn Trp Asp Ile Gly Ser Asn Pro Lys Ile Asn Asp 
                965                 970                 975     


Leu Ala Thr Gln Tyr Ile Val Asn Ser Asn Asp Ile His Ile Ile Gly 
            980                 985                 990         


Ile Asp Arg Gly Glu Asn His Leu  Ile Tyr Tyr Ser Val  Ile Asp Leu 
        995                 1000                 1005             


Gln Gly  Ala Ile Val Glu Gln  Gly Ser Leu Asn Thr  Ile Thr Glu 
    1010                 1015                 1020             


Tyr Thr  Glu Asn Lys Phe Leu  Asn Asn Lys Thr Asn  Asn Leu Arg 
    1025                 1030                 1035             


Lys Ile  Pro Tyr Lys Asp Ile  Leu Gln Gln Arg Glu  Asp Glu Arg 
    1040                 1045                 1050             


Ala Asp  Ala Arg Ile Lys Trp  His Ala Ile Asp Lys  Ile Lys Asp 
    1055                 1060                 1065             


Leu Lys  Asp Gly Tyr Leu Gly  Gln Ile Val His Phe  Leu Ala Lys 
    1070                 1075                 1080             


Leu Ile  Ile Lys Tyr Asn Ala  Ile Val Ile Leu Glu  Asp Leu Asn 
    1085                 1090                 1095             


Tyr Gly  Phe Lys Arg Gly Arg  Phe Lys Val Glu Arg  Gln Val Tyr 
    1100                 1105                 1110             


Gln Lys  Phe Glu Met Ala Leu  Met Lys Lys Leu Asn  Val Leu Val 
    1115                 1120                 1125             


Phe Lys  Asp Tyr Asp Ile Asp  Glu Ile Gly Gly Pro  Leu Lys Pro 
    1130                 1135                 1140             


Trp Gln  Leu Thr Arg Pro Ile  Asp Ser Tyr Glu Arg  Met Gly Arg 
    1145                 1150                 1155             


Gln Asn  Gly Ile Leu Phe Tyr  Val Pro Ala Ala Tyr  Thr Ser Ala 
    1160                 1165                 1170             


Val Asp  Pro Val Thr Gly Phe  Ala Asn Leu Phe Tyr  Leu Asn Asn 
    1175                 1180                 1185             


Val Lys  Asn Ser Glu Lys Phe  His Phe Phe Ser Lys  Phe Glu Ser 
    1190                 1195                 1200             


Ile Lys  Tyr His Ser Asp Gln  Asp Met Phe Ser Phe  Ala Phe Asp 
    1205                 1210                 1215             


Tyr Asn  Asn Phe Gly Thr Thr  Thr Arg Ile Asn Asp  Leu Ser Lys 
    1220                 1225                 1230             


Ser Lys  Trp Gln Val Phe Thr  Asn His Glu Arg Ser  Val Trp Asn 
    1235                 1240                 1245             


Asn Lys  Glu Lys Asn Tyr Val  Thr Gln Asn Leu Thr  Asp Leu Ile 
    1250                 1255                 1260             


Lys Lys  Leu Leu Arg Thr Tyr  Asn Ile Glu Phe Lys  Asn Asn Gln 
    1265                 1270                 1275             


Asn Val  Leu Asp Ser Ile Leu  Lys Ile Glu Asn Asn  Thr Asp Lys 
    1280                 1285                 1290             


Glu Asn  Phe Ala Arg Glu Leu  Phe Arg Leu Phe Arg  Leu Thr Ile 
    1295                 1300                 1305             


Gln Leu  Arg Asn Thr Thr Val  Asn Glu Asn Asn Thr  Glu Ile Thr 
    1310                 1315                 1320             


Glu Asn  Glu Leu Asp Tyr Ile  Ile Ser Pro Val Lys  Asp Lys Asn 
    1325                 1330                 1335             


Gly Asn  Phe Phe Asp Ser Arg  Asp Glu Leu Lys Asn  Leu Pro Asp 
    1340                 1345                 1350             


Asn Gly  Asp Ala Asn Gly Ala  Tyr Asn Ile Ala Arg  Lys Gly Leu 
    1355                 1360                 1365             


Leu Tyr  Ile Glu Gln Leu Gln  Glu Ser Ile Lys Thr  Gly Lys Leu 
    1370                 1375                 1380             


Pro Thr  Leu Ser Ile Ser Thr  Leu Asp Trp Phe Asn  Tyr Ile Met 
    1385                 1390                 1395             


Lys 
    


<210>  26
<211>  1313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  26

Met Asn Lys Gly Gly Tyr Val Ile Met Glu Lys Met Thr Glu Lys Asn 
1               5                   10                  15      


Arg Trp Glu Asn Gln Phe Arg Ile Thr Lys Thr Ile Lys Glu Glu Ile 
            20                  25                  30          


Ile Pro Thr Gly Tyr Thr Lys Val Asn Leu Gln Arg Val Asn Met Leu 
        35                  40                  45              


Lys Arg Glu Met Glu Arg Asn Glu Asp Leu Lys Lys Met Lys Glu Ile 
    50                  55                  60                  


Cys Asp Glu Tyr Tyr Arg Asn Met Ile Asp Val Ser Leu Arg Leu Glu 
65                  70                  75                  80  


Gln Val Arg Thr Leu Gly Trp Glu Ser Leu Ile His Lys Tyr Arg Met 
                85                  90                  95      


Leu Asn Lys Asp Glu Lys Glu Ile Lys Ala Leu Glu Lys Glu Gln Glu 
            100                 105                 110         


Asp Leu Arg Lys Lys Ile Ser Lys Gly Phe Gly Glu Lys Lys Ala Trp 
        115                 120                 125             


Thr Gly Glu Gln Phe Ile Lys Lys Ile Leu Pro Gln Tyr Leu Met Asp 
    130                 135                 140                 


His Tyr Thr Gly Glu Glu Leu Glu Glu Lys Leu Arg Ile Val Lys Lys 
145                 150                 155                 160 


Phe Lys Gly Cys Thr Met Phe Leu Ser Thr Phe Phe Lys Asn Arg Glu 
                165                 170                 175     


Asn Ile Phe Thr Asp Lys Pro Ile His Thr Ala Val Gly His Arg Ile 
            180                 185                 190         


Thr Ser Glu Asn Ala Met Leu Phe Ala Ala Asn Ile Asn Thr Tyr Glu 
        195                 200                 205             


Lys Met Glu Ser Asn Val Thr Leu Glu Ile Glu Arg Leu Gln Arg Glu 
    210                 215                 220                 


Phe Trp Arg Arg Gly Ile Asn Ile Ser Glu Ile Phe Thr Asp Ala Tyr 
225                 230                 235                 240 


Tyr Val Asn Val Leu Thr Gln Lys Gln Ile Glu Ala Tyr Asn Lys Ile 
                245                 250                 255     


Cys Gly Asp Ile Asn Gln His Met Asn Glu Tyr Cys Gln Lys Gln Lys 
            260                 265                 270         


Leu Lys Phe Ser Glu Phe Arg Met Arg Glu Leu Lys Lys Gln Ile Leu 
        275                 280                 285             


Ala Val Val Gly Glu His Phe Glu Ile Pro Glu Lys Ile Glu Ser Thr 
    290                 295                 300                 


Lys Glu Val Tyr Arg Glu Leu Asn Glu Tyr Tyr Glu Ser Leu Lys Glu 
305                 310                 315                 320 


Leu His Gly Gln Phe Glu Glu Leu Lys Ser Val Gln Leu Lys Tyr Ser 
                325                 330                 335     


Gln Ile Tyr Val Gln Lys Lys Gly Tyr Asp Arg Ile Ser Arg Tyr Ile 
            340                 345                 350         


Gly Gly Gln Trp Asp Leu Ile Gln Glu Cys Met Lys Lys Asp Cys Ala 
        355                 360                 365             


Ser Gly Met Lys Gly Thr Lys Lys Asn His Asp Ala Lys Ile Glu Glu 
    370                 375                 380                 


Glu Val Ala Lys Val Lys Tyr Gln Ser Ile Glu His Ile Gln Lys Leu 
385                 390                 395                 400 


Val Cys Thr Tyr Glu Glu Asp Arg Gly His Lys Val Thr Asp Tyr Val 
                405                 410                 415     


Asp Glu Phe Ile Val Ser Val Cys Asp Leu Leu Gly Ala Asp His Ile 
            420                 425                 430         


Ile Thr Arg Asp Gly Glu Arg Ile Glu Leu Pro Leu Gln Tyr Glu Pro 
        435                 440                 445             


Gly Thr Asp Leu Leu Lys Asn Asp Thr Ile Asn Gln Arg Arg Leu Ser 
    450                 455                 460                 


Asp Ile Lys Thr Ile Leu Asp Trp His Met Asp Met Leu Glu Trp Leu 
465                 470                 475                 480 


Lys Thr Phe Leu Val Asn Asp Leu Val Ile Lys Asp Glu Glu Phe Tyr 
                485                 490                 495     


Met Ala Ile Glu Glu Leu Asn Glu Arg Met Gln Cys Val Ile Ser Val 
            500                 505                 510         


Tyr Asn Arg Ile Arg Asn Tyr Val Thr Gln Lys Gly Tyr Glu Pro Glu 
        515                 520                 525             


Lys Ile Arg Ile Cys Phe Asp Lys Gly Thr Ile Leu Thr Gly Trp Thr 
    530                 535                 540                 


Thr Gly Asp Asn Tyr Gln Tyr Ser Gly Phe Leu Leu Met Arg Asn Asp 
545                 550                 555                 560 


Lys Tyr Tyr Leu Gly Ile Ile Asn Thr Asn Glu Lys Ser Val Arg Lys 
                565                 570                 575     


Ile Leu Asp Gly Asn Glu Glu Cys Lys Asp Glu Asn Asp Tyr Ile Arg 
            580                 585                 590         


Val Gly Tyr His Leu Ile Asn Asp Ala Ser Lys Gln Leu Pro Arg Ile 
        595                 600                 605             


Phe Val Met Pro Lys Ala Gly Lys Lys Ser Glu Ile Leu Met Lys Asp 
    610                 615                 620                 


Glu Gln Cys Asp Tyr Ile Trp Asp Gly Tyr Cys His Asn Lys His Asn 
625                 630                 635                 640 


Glu Ser Lys Glu Phe Met Arg Glu Leu Ile Asp Tyr Tyr Lys Arg Ser 
                645                 650                 655     


Ile Met Asn Tyr Asp Lys Trp Glu Gly Tyr Cys Phe Lys Phe Ser Ser 
            660                 665                 670         


Thr Glu Ser Tyr Asp Asn Met Gln Asp Phe Tyr Lys Glu Val Arg Glu 
        675                 680                 685             


Gln Ser Tyr Asn Ile Ser Phe Ser Tyr Ile Asn Glu Asn Val Leu Glu 
    690                 695                 700                 


Gln Leu Asp Lys Asp Gly Lys Ile Tyr Leu Phe Gln Val Tyr Asn Lys 
705                 710                 715                 720 


Asp Phe Ala Ala Gly Ser Thr Gly Thr Pro Asn Leu His Thr Met Tyr 
                725                 730                 735     


Leu Gln Asn Leu Phe Ser Ser Gln Asn Leu Glu Leu Lys Arg Leu Arg 
            740                 745                 750         


Leu Gly Gly Asn Ala Glu Leu Phe Tyr Arg Pro Gly Thr Glu Lys Asp 
        755                 760                 765             


Val Thr His Arg Lys Gly Ser Ile Leu Val Asp Arg Thr Tyr Val Arg 
    770                 775                 780                 


Glu Glu Lys Asp Gly Ile Glu Val Arg Asp Thr Val Pro Glu Lys Glu 
785                 790                 795                 800 


Tyr Leu Glu Ile Tyr Arg Tyr Leu Asn Gly Lys Gln Lys Gly Asp Leu 
                805                 810                 815     


Ser Glu Ser Ala Lys Gln Trp Leu Asp Lys Val His Tyr Arg Glu Ala 
            820                 825                 830         


Pro Cys Asp Ile Ile Lys Asp Lys Arg Tyr Ala Gln Glu Lys Tyr Phe 
        835                 840                 845             


Leu His Phe Ser Val Glu Ile Asn Pro Asn Ala Glu Gly Gln Thr Ala 
    850                 855                 860                 


Leu Asn Asp Asn Val Arg Arg Trp Leu Ser Glu Glu Glu Asp Ile His 
865                 870                 875                 880 


Val Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu Ile Tyr Val Ser Leu 
                885                 890                 895     


Met Asp Gly Lys Gly Arg Ile Lys Asp Gln Lys Ser Tyr Asn Ile Val 
            900                 905                 910         


Asn Ser Gly Asn Lys Glu Pro Val Asp Tyr Leu Ala Lys Leu Lys Val 
        915                 920                 925             


Arg Glu Lys Glu Arg Asp Glu Ala Arg Arg Asn Trp Lys Ala Ile Gly 
    930                 935                 940                 


Lys Ile Lys Asp Ile Lys Thr Gly Tyr Leu Ser Tyr Val Val His Glu 
945                 950                 955                 960 


Ile Val Glu Met Ala Val Arg Glu Lys Ala Ile Ile Val Met Glu Asp 
                965                 970                 975     


Leu Asn Tyr Gly Phe Lys Arg Gly Arg Phe Lys Val Glu Arg Gln Val 
            980                 985                 990         


Tyr Gln Lys Phe Glu Glu Met Leu  Ile Asn Lys Leu Asn  Tyr Val Val 
        995                 1000                 1005             


Asp Lys  Gln Leu Ser Val Asp  Glu Pro Gly Gly Leu  Leu Arg Gly 
    1010                 1015                 1020             


Tyr Gln  Leu Ala Phe Ile Pro  Lys Asp Lys Lys Ser  Ser Met Arg 
    1025                 1030                 1035             


Gln Asn  Gly Ile Val Phe Tyr  Val Pro Ala Gly Tyr  Thr Ser Lys 
    1040                 1045                 1050             


Ile Asp  Pro Thr Thr Gly Phe  Val Asn Ile Phe Lys  Phe Pro Gln 
    1055                 1060                 1065             


Phe Gly  Lys Gly Asp Asp Asp  Gly Asn Gly Lys Asp  Tyr Asp Lys 
    1070                 1075                 1080             


Ile Arg  Ala Phe Phe Gly Lys  Phe Asp Glu Ile Arg  Tyr Glu Cys 
    1085                 1090                 1095             


Asp Glu  Lys Val Thr Ala Asp  Asn Thr Arg Glu Val  Lys Glu Arg 
    1100                 1105                 1110             


Tyr Arg  Phe Asp Phe Asp Tyr  Ser Lys Phe Glu Thr  His Leu Val 
    1115                 1120                 1125             


His Met  Lys Lys Thr Lys Trp  Thr Val Tyr Ala Glu  Gly Glu Arg 
    1130                 1135                 1140             


Ile Lys  Arg Lys Lys Val Gly  Asn Tyr Trp Thr Ser  Glu Val Ile 
    1145                 1150                 1155             


Ser Asp  Ile Ala Leu Arg Met  Ser Asn Thr Leu Asn  Ile Ala Gly 
    1160                 1165                 1170             


Ile Glu  Tyr Lys Asp Gly His  Asn Leu Val Asn Glu  Ile Cys Ala 
    1175                 1180                 1185             


Leu Arg  Gly Lys Gln Ala Gly  Ile Ile Leu Asn Glu  Leu Leu Glu 
    1190                 1195                 1200             


Ile Val  Arg Leu Thr Val Gln  Leu Arg Asn Ser Thr  Thr Glu Gly 
    1205                 1210                 1215             


Asp Val  Asp Glu Arg Asp Glu  Ile Ile Ser Pro Val  Leu Asn Glu 
    1220                 1225                 1230             


Lys Tyr  Gly Cys Phe Tyr His  Ser Thr Glu Tyr Lys  Gln Gln Asn 
    1235                 1240                 1245             


Gly Asp  Val Leu Pro Lys Asp  Ala Asp Ala Asn Gly  Ala Tyr Cys 
    1250                 1255                 1260             


Ile Gly  Leu Lys Gly Ile Tyr  Glu Ile Arg Gln Ile  Lys Asn Lys 
    1265                 1270                 1275             


Trp Lys  Glu Asp Met Thr Lys  Gly Glu Gly Lys Ala  Leu Asn Glu 
    1280                 1285                 1290             


Gly Met  Arg Ile Ser His Asp  Gln Trp Phe Glu Phe  Ile Gln Asn 
    1295                 1300                 1305             


Met Asn  Lys Gly Glu 
    1310             


<210>  27
<211>  1470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  27

Met Asn Asn Pro Arg Gly Ala Phe Gly Gly Phe Thr Asn Leu Tyr Ser 
1               5                   10                  15      


Leu Ser Lys Thr Leu Arg Phe Glu Leu Lys Pro Tyr Leu Glu Ile Pro 
            20                  25                  30          


Glu Gly Glu Lys Gly Lys Leu Phe Gly Asp Asp Lys Glu Tyr Tyr Lys 
        35                  40                  45              


Asn Cys Lys Thr Tyr Thr Glu Tyr Tyr Leu Lys Lys Ala Asn Lys Glu 
    50                  55                  60                  


Tyr Tyr Asp Asn Glu Lys Val Lys Asn Thr Asp Leu Gln Leu Val Asn 
65                  70                  75                  80  


Phe Leu His Asp Glu Arg Ile Glu Asp Ala Tyr Gln Val Leu Lys Pro 
                85                  90                  95      


Val Phe Asp Thr Leu His Glu Glu Phe Ile Thr Asp Ser Leu Glu Ser 
            100                 105                 110         


Ala Glu Ala Lys Lys Ile Asp Phe Gly Asn Tyr Tyr Gly Leu Tyr Glu 
        115                 120                 125             


Lys Gln Lys Ser Glu Gln Asn Lys Asp Glu Lys Lys Lys Ile Asp Lys 
    130                 135                 140                 


Pro Leu Glu Thr Glu Arg Gly Lys Leu Arg Lys Ala Phe Thr Pro Ile 
145                 150                 155                 160 


Tyr Glu Ala Glu Gly Lys Asn Leu Lys Asn Lys Ala Gly Lys Glu Lys 
                165                 170                 175     


Lys Asp Lys Asp Ile Leu Lys Glu Ser Gly Phe Lys Val Leu Ile Glu 
            180                 185                 190         


Ala Gly Ile Leu Lys Tyr Ile Lys Asn Asn Ile Asp Glu Phe Ala Asp 
        195                 200                 205             


Lys Lys Leu Lys Asn Asn Glu Gly Lys Glu Ile Thr Lys Lys Asp Ile 
    210                 215                 220                 


Glu Thr Ala Leu Gly Ala Glu Asn Ile Glu Gly Ile Phe Asp Gly Phe 
225                 230                 235                 240 


Phe Thr Tyr Phe Ser Gly Phe Asn Gln Asn Arg Glu Asn Tyr Tyr Ser 
                245                 250                 255     


Thr Glu Glu Lys Ala Thr Ala Val Ala Ser Arg Ile Val Asp Glu Asn 
            260                 265                 270         


Leu Ser Lys Phe Cys Asp Asn Ile Leu Leu Tyr Arg Lys Asn Glu Asn 
        275                 280                 285             


Asp Tyr Leu Lys Ile Phe Asn Phe Leu Lys Asn Lys Gly Lys Asp Leu 
    290                 295                 300                 


Lys Leu Lys Asn Ser Lys Phe Gly Lys Glu Asn Glu Pro Glu Phe Ile 
305                 310                 315                 320 


Pro Ala Tyr Asp Met Lys Asn Asp Glu Lys Ser Phe Ser Val Ala Asp 
                325                 330                 335     


Phe Val Asn Cys Leu Ser Gln Gly Glu Ile Glu Lys Tyr Asn Ala Lys 
            340                 345                 350         


Ile Ala Asn Ala Asn Tyr Leu Ile Asn Leu Tyr Asn Gln Asn Lys Asp 
        355                 360                 365             


Gly Asn Ser Ser Lys Leu Ser Met Phe Lys Ile Leu Tyr Lys Gln Ile 
    370                 375                 380                 


Gly Cys Gly Glu Lys Lys Asp Phe Ile Lys Thr Ile Lys Asp Asn Ala 
385                 390                 395                 400 


Glu Leu Lys Gln Ile Leu Glu Lys Ala Cys Glu Ala Gly Lys Lys Tyr 
                405                 410                 415     


Phe Ile Arg Gly Lys Ser Glu Asp Gly Gly Val Ser Asn Ile Phe Asp 
            420                 425                 430         


Phe Thr Asp Tyr Ile Gln Ser His Glu Asn Tyr Lys Gly Val Tyr Trp 
        435                 440                 445             


Ser Asp Lys Ala Ile Asn Thr Ile Ser Gly Lys Tyr Phe Ala Asn Trp 
    450                 455                 460                 


Asp Thr Leu Lys Asn Lys Leu Gly Asp Ala Lys Val Phe Asn Lys Asn 
465                 470                 475                 480 


Thr Gly Glu Asp Lys Ala Asp Val Lys Tyr Lys Val Pro Gln Ala Val 
                485                 490                 495     


Met Leu Ser Glu Leu Phe Ala Val Leu Asp Asp Asn Ala Gly Glu Asp 
            500                 505                 510         


Trp Arg Glu Lys Gly Ile Phe Phe Lys Ala Ser Leu Phe Glu Gly Asp 
        515                 520                 525             


Gln Asn Lys Ser Glu Ile Ile Lys Asn Ala Asn Arg Pro Ser Gln Ala 
    530                 535                 540                 


Leu Leu Lys Met Ile Cys Asp Asp Met Glu Ser Leu Ala Lys Asn Phe 
545                 550                 555                 560 


Ile Asp Ser Gly Asp Lys Ile Leu Lys Ile Ser Asp Arg Asp Tyr Gln 
                565                 570                 575     


Lys Asp Glu Asn Lys Gln Lys Ile Lys Asn Trp Leu Asp Asn Ala Leu 
            580                 585                 590         


Trp Ile Asn Gln Ile Leu Lys Tyr Phe Lys Val Lys Ala Asn Lys Ile 
        595                 600                 605             


Lys Gly Asp Ser Ile Asp Ala Arg Ile Asp Ser Gly Leu Asp Met Leu 
    610                 615                 620                 


Val Phe Ser Ser Asp Asn Pro Ala Glu Asp Tyr Asp Met Ile Arg Asn 
625                 630                 635                 640 


Tyr Leu Thr Gln Lys Pro Gln Asp Glu Ile Asn Lys Leu Lys Leu Asn 
                645                 650                 655     


Phe Glu Asn Ser Ser Leu Ala Gly Gly Trp Asp Glu Asn Lys Glu Lys 
            660                 665                 670         


Asp Asn Ser Cys Ile Ile Leu Lys Asp Glu Gln Asp Lys Gln Tyr Leu 
        675                 680                 685             


Ala Val Met Lys Tyr Glu Asn Thr Lys Val Phe Glu Gln Lys Asn Ser 
    690                 695                 700                 


Gln Leu Tyr Ile Ala Asp Asn Ala Ala Trp Lys Lys Met Ile Tyr Lys 
705                 710                 715                 720 


Leu Val Pro Gly Ala Ser Lys Thr Leu Pro Lys Val Phe Phe Ser Lys 
                725                 730                 735     


Lys Trp Thr Ala Asn Arg Pro Thr Pro Ser Asp Ile Val Glu Ile Tyr 
            740                 745                 750         


Gln Lys Gly Ser Phe Lys Lys Glu Asn Val Asp Phe Asn Asp Lys Lys 
        755                 760                 765             


Glu Lys Asp Glu Ser Arg Lys Glu Lys Asn Arg Glu Lys Ile Ile Ala 
    770                 775                 780                 


Glu Leu Gln Lys Thr Cys Trp Met Asp Ile Arg Tyr Asn Ile Asp Gly 
785                 790                 795                 800 


Lys Ile Glu Ser Ala Lys Tyr Val Asn Lys Glu Lys Leu Ala Lys Leu 
                805                 810                 815     


Ile Asp Phe Tyr Lys Glu Asn Leu Lys Lys Tyr Pro Ser Glu Glu Glu 
            820                 825                 830         


Ser Trp Asp Arg Leu Phe Ala Phe Gly Phe Ser Asp Thr Lys Ser Tyr 
        835                 840                 845             


Lys Ser Ile Asp Gln Phe Tyr Ile Glu Val Asp Lys Gln Gly Tyr Lys 
    850                 855                 860                 


Leu Glu Phe Val Thr Ile Asn Lys Ala Arg Leu Asp Glu Tyr Val Arg 
865                 870                 875                 880 


Asp Gly Lys Ile Tyr Leu Phe Glu Ile Arg Ser Arg Asp Asn Asn Leu 
                885                 890                 895     


Val Asn Gly Glu Glu Lys Thr Ser Ala Lys Asn Leu Gln Thr Ile Tyr 
            900                 905                 910         


Trp Asn Ala Ala Phe Gly Gly Asp Asp Asn Lys Pro Lys Leu Asn Gly 
        915                 920                 925             


Glu Ala Glu Ile Phe Tyr Arg Pro Ala Ile Ala Glu Asn Lys Leu Asn 
    930                 935                 940                 


Lys Lys Lys Asp Lys Asn Gly Lys Glu Ile Ile Asp Gly Tyr Arg Phe 
945                 950                 955                 960 


Ser Lys Glu Lys Phe Ile Phe His Cys Pro Ile Thr Leu Asn Phe Cys 
                965                 970                 975     


Leu Lys Glu Thr Lys Ile Asn Asp Lys Leu Asn Ala Ala Leu Ala Lys 
            980                 985                 990         


Pro Glu Asn Gly Gln Gly Val Tyr  Phe Leu Gly Ile Asp  Arg Gly Glu 
        995                 1000                 1005             


Lys His  Leu Ala Tyr Tyr Ser  Leu Val Asn Gln Lys  Gly Glu Ile 
    1010                 1015                 1020             


Leu Glu  Gln Gly Thr Leu Asn  Leu Pro Phe Leu Asp  Lys Asn Gly 
    1025                 1030                 1035             


Lys Ser  Arg Ser Ile Lys Val  Glu Lys Lys Ser Phe  Glu Lys Asp 
    1040                 1045                 1050             


Ser Asn  Gly Gly Ile Ile Lys  Asp Lys Asp Gly Asn  Asp Lys Ile 
    1055                 1060                 1065             


Lys Ile  Glu Phe Val Glu Cys  Trp Asn Tyr Asn Asp  Leu Leu Asp 
    1070                 1075                 1080             


Ala Arg  Ala Gly Asp Arg Asp  Tyr Ala Arg Lys Asn  Trp Thr Thr 
    1085                 1090                 1095             


Ile Gly  Thr Ile Lys Glu Leu  Lys Asp Gly Tyr Ile  Ser Gln Val 
    1100                 1105                 1110             


Val Arg  Lys Ile Val Asp Leu  Ser Ile Tyr Lys Asn  Thr Glu Thr 
    1115                 1120                 1125             


Lys Glu  Phe Arg Glu Met Pro  Ala Phe Ile Val Leu  Glu Asp Leu 
    1130                 1135                 1140             


Asn Ile  Gly Phe Lys Arg Gly  Arg Gln Lys Ile Glu  Lys Gln Val 
    1145                 1150                 1155             


Tyr Gln  Lys Leu Glu Leu Ala  Leu Ala Lys Lys Leu  Asn Phe Leu 
    1160                 1165                 1170             


Val Asp  Lys Lys Ala Asp Ile  Gly Glu Ile Gly Ser  Val Thr Lys 
    1175                 1180                 1185             


Ala Ile  Gln Leu Thr Pro Pro  Val Asn Asn Phe Gly  Asp Met Glu 
    1190                 1195                 1200             


Asn Arg  Lys Gln Phe Gly Asn  Met Leu Tyr Ile Arg  Ala Asp Tyr 
    1205                 1210                 1215             


Thr Ser  Gln Thr Asp Pro Ala  Thr Gly Trp Arg Lys  Ser Ile Tyr 
    1220                 1225                 1230             


Leu Lys  Ser Gly Ser Glu Ser  Asn Val Lys Glu Gln  Ile Glu Lys 
    1235                 1240                 1245             


Ser Phe  Phe Asp Ile Arg Tyr  Glu Ser Gly Asp Tyr  Cys Phe Glu 
    1250                 1255                 1260             


Tyr Arg  Asp Arg His Gly Lys  Met Trp Gln Leu Tyr  Ser Ser Lys 
    1265                 1270                 1275             


Asn Gly  Val Ser Leu Asp Arg  Phe His Gly Glu Arg  Asn Asn Ser 
    1280                 1285                 1290             


Lys Asn  Val Trp Glu Ser Glu  Lys Gln Pro Leu Asn  Glu Met Leu 
    1295                 1300                 1305             


Asp Ile  Leu Phe Asp Glu Lys  Arg Phe Asp Lys Ser  Lys Ser Leu 
    1310                 1315                 1320             


Tyr Glu  Gln Met Phe Lys Gly  Gly Val Ala Leu Thr  Arg Leu Pro 
    1325                 1330                 1335             


Lys Glu  Ile Asn Lys Lys Asp  Lys Pro Ala Trp Glu  Ser Leu Arg 
    1340                 1345                 1350             


Phe Val  Ile Ile Leu Ile Gln  Gln Ile Arg Asn Thr  Gly Lys Asn 
    1355                 1360                 1365             


Gly Asp  Asp Arg Asn Gly Asp  Phe Ile Gln Ser Pro  Val Arg Asp 
    1370                 1375                 1380             


Glu Lys  Thr Gly Glu His Phe  Asp Ser Arg Ile Tyr  Leu Asp Lys 
    1385                 1390                 1395             


Glu Gln  Lys Gly Glu Lys Ala  Asp Leu Pro Thr Ser  Gly Asp Ala 
    1400                 1405                 1410             


Asn Gly  Ala Tyr Asn Ile Ala  Arg Lys Gly Ile Val  Val Ala Glu 
    1415                 1420                 1425             


His Ile  Lys Arg Gly Phe Asp  Lys Leu Tyr Ile Ser  Asp Glu Glu 
    1430                 1435                 1440             


Trp Asp  Thr Trp Leu Ala Gly  Asp Glu Ile Trp Asp  Lys Trp Leu 
    1445                 1450                 1455             


Lys Glu  Asn Arg Glu Ser Leu  Thr Lys Thr Arg Lys  
    1460                 1465                 1470 


<210>  28
<211>  1259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  28

Met Asn Tyr Lys Thr Gly Leu Glu Asp Phe Ile Gly Lys Glu Ser Leu 
1               5                   10                  15      


Ser Lys Thr Leu Arg Asn Ala Leu Ile Pro Thr Glu Ser Thr Lys Ile 
            20                  25                  30          


His Met Glu Glu Met Gly Val Ile Arg Asp Asp Glu Leu Arg Ala Glu 
        35                  40                  45              


Lys Gln Gln Glu Leu Lys Glu Ile Met Asp Asp Tyr Tyr Arg Thr Phe 
    50                  55                  60                  


Ile Glu Glu Lys Leu Gly Gln Ile Gln Gly Ile Gln Trp Asn Ser Leu 
65                  70                  75                  80  


Phe Gln Lys Met Glu Glu Thr Met Glu Asp Ile Ser Val Arg Lys Asp 
                85                  90                  95      


Leu Asp Lys Ile Gln Asn Glu Lys Arg Lys Glu Ile Cys Cys Tyr Phe 
            100                 105                 110         


Thr Ser Asp Lys Arg Phe Lys Asp Leu Phe Asn Ala Lys Leu Ile Thr 
        115                 120                 125             


Asp Ile Leu Pro Asn Phe Ile Lys Asp Asn Lys Glu Tyr Thr Glu Glu 
    130                 135                 140                 


Glu Lys Ala Glu Lys Glu Gln Thr Arg Val Leu Phe Gln Arg Phe Ala 
145                 150                 155                 160 


Thr Ala Phe Thr Asn Tyr Phe Asn Gln Arg Arg Asn Asn Phe Ser Glu 
                165                 170                 175     


Asp Asn Ile Ser Thr Ala Ile Ser Phe Arg Ile Val Asn Glu Asn Ser 
            180                 185                 190         


Glu Ile His Leu Gln Asn Met Arg Ala Phe Gln Arg Ile Glu Gln Gln 
        195                 200                 205             


Tyr Pro Glu Glu Val Cys Gly Met Glu Glu Glu Tyr Lys Asp Met Leu 
    210                 215                 220                 


Gln Glu Trp Gln Met Lys His Ile Tyr Ser Val Asp Phe Tyr Asp Arg 
225                 230                 235                 240 


Glu Leu Thr Gln Pro Gly Ile Glu Tyr Tyr Asn Gly Ile Cys Gly Lys 
                245                 250                 255     


Ile Asn Glu His Met Asn Gln Phe Cys Gln Lys Asn Arg Ile Asn Lys 
            260                 265                 270         


Asn Asp Phe Arg Met Lys Lys Leu His Lys Gln Ile Leu Cys Lys Lys 
        275                 280                 285             


Ser Ser Tyr Tyr Glu Ile Pro Phe Arg Phe Glu Ser Asp Gln Glu Val 
    290                 295                 300                 


Tyr Asp Ala Leu Asn Glu Phe Ile Lys Thr Met Lys Lys Lys Glu Ile 
305                 310                 315                 320 


Ile Arg Arg Cys Val His Leu Gly Gln Glu Cys Asp Asp Tyr Asp Leu 
                325                 330                 335     


Gly Lys Ile Tyr Ile Ser Ser Asn Lys Tyr Glu Gln Ile Ser Asn Ala 
            340                 345                 350         


Leu Tyr Gly Ser Trp Asp Thr Ile Arg Lys Cys Ile Lys Glu Glu Tyr 
        355                 360                 365             


Met Asp Ala Leu Pro Gly Lys Gly Glu Lys Lys Glu Glu Lys Ala Glu 
    370                 375                 380                 


Ala Ala Ala Lys Lys Glu Glu Tyr Arg Ser Ile Ala Asp Ile Asp Lys 
385                 390                 395                 400 


Ile Ile Ser Leu Tyr Gly Ser Glu Met Asp Arg Thr Ile Ser Ala Lys 
                405                 410                 415     


Lys Cys Ile Thr Glu Ile Cys Asp Met Ala Gly Gln Ile Ser Ile Asp 
            420                 425                 430         


Pro Leu Val Cys Asn Ser Asp Ile Lys Leu Leu Gln Asn Lys Glu Lys 
        435                 440                 445             


Thr Thr Glu Ile Lys Thr Ile Leu Asp Ser Phe Leu His Val Tyr Gln 
    450                 455                 460                 


Trp Gly Gln Thr Phe Ile Val Ser Asp Ile Ile Glu Lys Asp Ser Tyr 
465                 470                 475                 480 


Phe Tyr Ser Glu Leu Glu Asp Val Leu Glu Asp Phe Glu Gly Ile Thr 
                485                 490                 495     


Thr Leu Tyr Asn His Val Arg Ser Tyr Val Thr Gln Lys Pro Tyr Ser 
            500                 505                 510         


Thr Val Lys Phe Lys Leu His Phe Gly Ser Pro Thr Leu Ala Asn Gly 
        515                 520                 525             


Trp Ser Gln Ser Lys Glu Tyr Asp Asn Asn Ala Ile Leu Leu Met Arg 
    530                 535                 540                 


Asp Gln Lys Phe Tyr Leu Gly Ile Phe Asn Val Arg Asn Lys Pro Asp 
545                 550                 555                 560 


Lys Gln Ile Ile Lys Gly His Glu Lys Glu Glu Lys Gly Asp Tyr Lys 
                565                 570                 575     


Lys Met Ile Tyr Asn Leu Leu Pro Gly Pro Ser Lys Met Leu Pro Lys 
            580                 585                 590         


Val Phe Ile Thr Ser Arg Ser Gly Gln Glu Thr Tyr Lys Pro Ser Lys 
        595                 600                 605             


His Ile Leu Asp Gly Tyr Asn Glu Lys Arg His Ile Lys Ser Ser Pro 
    610                 615                 620                 


Lys Phe Asp Leu Gly Tyr Cys Trp Asp Leu Ile Asp Tyr Tyr Lys Glu 
625                 630                 635                 640 


Cys Ile His Lys His Pro Asp Trp Lys Asn Tyr Asp Phe His Phe Ser 
                645                 650                 655     


Asp Thr Lys Asp Tyr Glu Asp Ile Ser Gly Phe Tyr Arg Glu Val Glu 
            660                 665                 670         


Met Gln Gly Tyr Gln Ile Lys Trp Thr Tyr Ile Ser Ala Asp Glu Ile 
        675                 680                 685             


Gln Lys Leu Asp Glu Lys Gly Gln Ile Phe Leu Phe Gln Ile Tyr Asn 
    690                 695                 700                 


Lys Asp Phe Ser Val His Ser Thr Gly Lys Asp Asn Leu His Thr Met 
705                 710                 715                 720 


Tyr Leu Lys Asn Leu Phe Ser Glu Glu Asn Leu Lys Asp Ile Val Leu 
                725                 730                 735     


Lys Leu Asn Gly Glu Ala Glu Leu Phe Phe Arg Lys Ala Ser Ile Lys 
            740                 745                 750         


Thr Pro Ile Val His Lys Lys Gly Ser Val Leu Val Asn Arg Ser Tyr 
        755                 760                 765             


Thr Gln Thr Val Gly Asn Lys Glu Ile Arg Val Ser Ile Pro Glu Glu 
    770                 775                 780                 


Tyr Tyr Thr Glu Ile Tyr Asn Tyr Leu Asn His Ile Gly Lys Gly Lys 
785                 790                 795                 800 


Leu Ser Ser Glu Ala Gln Arg Tyr Leu Asp Glu Gly Lys Ile Lys Ser 
                805                 810                 815     


Phe Thr Ala Thr Lys Asp Ile Val Lys Asn Tyr Arg Tyr Cys Cys Asp 
            820                 825                 830         


His Tyr Phe Leu His Leu Pro Ile Thr Ile Asn Phe Lys Ala Lys Ser 
        835                 840                 845             


Asp Val Ala Val Asn Glu Arg Thr Leu Ala Tyr Ile Ala Lys Lys Glu 
    850                 855                 860                 


Asp Ile His Ile Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr 
865                 870                 875                 880 


Ile Ser Val Val Asp Val His Gly Asn Ile Arg Glu Gln Arg Ser Phe 
                885                 890                 895     


Asn Ile Val Asn Gly Tyr Asp Tyr Gln Gln Lys Leu Lys Asp Arg Glu 
            900                 905                 910         


Lys Ser Arg Asp Ala Ala Arg Lys Asn Trp Glu Glu Ile Glu Lys Ile 
        915                 920                 925             


Lys Glu Leu Lys Glu Gly Tyr Leu Ser Met Val Ile His Tyr Ile Ala 
    930                 935                 940                 


Gln Leu Val Val Lys Tyr Asn Ala Val Val Ala Met Glu Asp Leu Asn 
945                 950                 955                 960 


Tyr Gly Phe Lys Thr Gly Arg Phe Lys Val Glu Arg Gln Val Tyr Gln 
                965                 970                 975     


Lys Phe Glu Thr Met Leu Ile Glu Lys Leu His Tyr Leu Val Phe Lys 
            980                 985                 990         


Asp Arg Glu Val Cys Glu Glu Gly  Gly Val Leu Arg Gly  Tyr Gln Leu 
        995                 1000                 1005             


Thr Tyr  Ile Pro Glu Ser Leu  Lys Lys Val Gly Lys  Gln Cys Gly 
    1010                 1015                 1020             


Phe Ile  Phe Tyr Val Pro Ala  Gly Tyr Thr Ser Lys  Ile Asp Pro 
    1025                 1030                 1035             


Thr Thr  Gly Phe Val Asn Leu  Phe Ser Phe Lys Asn  Leu Thr Asn 
    1040                 1045                 1050             


Arg Glu  Ser Arg Gln Asp Phe  Val Gly Lys Phe Asp  Glu Ile Arg 
    1055                 1060                 1065             


Tyr Asp  Arg Asp Lys Lys Met  Phe Glu Phe Ser Phe  Asp Tyr Asn 
    1070                 1075                 1080             


Asn Tyr  Ile Lys Lys Gly Thr  Ile Leu Ala Ser Thr  Lys Trp Lys 
    1085                 1090                 1095             


Val Tyr  Thr Asn Gly Thr Arg  Leu Lys Lys Ile Val  Val Asn Gly 
    1100                 1105                 1110             


Lys Tyr  Thr Ser Gln Ser Met  Glu Val Glu Leu Thr  Asp Ala Met 
    1115                 1120                 1125             


Glu Lys  Met Leu Gln Arg Ala  Gly Ile Glu Tyr His  Asp Gly Lys 
    1130                 1135                 1140             


Asp Leu  Lys Gly Gln Ile Val  Glu Lys Gly Ile Glu  Ala Glu Ile 
    1145                 1150                 1155             


Ile Asp  Ile Phe Arg Leu Thr  Val Gln Met Arg Asn  Ser Arg Ser 
    1160                 1165                 1170             


Glu Ser  Glu Asp Arg Glu Tyr  Asp Arg Leu Ile Ser  Pro Val Leu 
    1175                 1180                 1185             


Asn Asp  Lys Gly Glu Phe Phe  Asp Thr Ala Thr Ala  Asp Lys Thr 
    1190                 1195                 1200             


Leu Pro  Gln Asp Ala Asp Ala  Asn Gly Ala Tyr Cys  Ile Ala Leu 
    1205                 1210                 1215             


Lys Gly  Leu Tyr Glu Val Lys  Gln Ile Lys Glu Asn  Trp Lys Glu 
    1220                 1225                 1230             


Asn Glu  Gln Phe Pro Arg Asn  Lys Leu Val Gln Asp  Asn Lys Thr 
    1235                 1240                 1245             


Trp Phe  Asp Phe Met Gln Lys  Lys Arg Tyr Leu 
    1250                 1255                 


<210>  29
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  29

Met Arg Ile Ser Lys Thr Leu Ser Leu Arg Ile Val Arg Pro Phe Tyr 
1               5                   10                  15      


Thr Pro Glu Val Glu Ala Gly Ile Lys Ala Glu Lys Asp Lys Arg Glu 
            20                  25                  30          


Ala Gln Gly Gln Thr Arg Ser Leu Asp Ala Lys Phe Phe Asn Glu Leu 
        35                  40                  45              


Lys Lys Lys His Ser Glu Ile Ile Leu Ser Ser Glu Phe Tyr Ser Leu 
    50                  55                  60                  


Leu Ser Glu Val Gln Arg Gln Leu Thr Ser Ile Tyr Asn His Ala Met 
65                  70                  75                  80  


Ser Asn Leu Tyr His Lys Ile Ile Val Glu Gly Glu Lys Thr Ser Thr 
                85                  90                  95      


Ser Lys Ala Leu Ser Asn Ile Gly Tyr Asp Glu Cys Lys Ala Ile Phe 
            100                 105                 110         


Pro Ser Tyr Met Ala Leu Gly Leu Arg Gln Lys Ile Gln Ser Asn Phe 
        115                 120                 125             


Arg Arg Arg Asp Leu Lys Asn Phe Arg Met Ala Val Pro Thr Ala Lys 
    130                 135                 140                 


Ser Asp Lys Phe Pro Ile Pro Ile Tyr Arg Gln Val Asp Gly Ser Lys 
145                 150                 155                 160 


Gly Gly Phe Lys Ile Ser Glu Asn Asp Gly Lys Asp Phe Ile Val Glu 
                165                 170                 175     


Leu Pro Leu Val Asp Tyr Val Ala Glu Glu Val Lys Thr Ala Lys Gly 
            180                 185                 190         


Arg Phe Thr Lys Ile Asn Ile Ser Lys Pro Pro Lys Ile Lys Asn Ile 
        195                 200                 205             


Pro Val Ile Leu Ser Thr Leu Arg Arg Arg Gln Ser Gly Gln Trp Phe 
    210                 215                 220                 


Ser Asp Asp Gly Thr Asn Ala Glu Ile Arg Arg Val Ile Ser Gly Glu 
225                 230                 235                 240 


Tyr Lys Val Ser Trp Ile Glu Ile Val Arg Arg Thr Arg Phe Gly Lys 
                245                 250                 255     


His Asp Asp Trp Phe Val Asn Met Val Ile Lys Tyr Asp Lys Pro Glu 
            260                 265                 270         


Glu Gly Leu Asp Ser Lys Val Val Gly Gly Ile Asp Val Gly Val Ser 
        275                 280                 285             


Ser Pro Leu Val Cys Ala Leu Asn Asn Ser Leu Asp Arg Tyr Phe Val 
    290                 295                 300                 


Lys Ser Ser Asp Ile Ile Ala Phe Asn Lys Arg Ala Met Ala Arg Arg 
305                 310                 315                 320 


Arg Thr Leu Leu Arg Gln Asn Lys Tyr Lys Arg Ser Gly His Gly Ser 
                325                 330                 335     


Lys Asn Lys Leu Glu Pro Ile Thr Val Leu Thr Glu Lys Asn Glu Arg 
            340                 345                 350         


Phe Lys Lys Ser Ile Met Gln Arg Trp Ala Lys Glu Val Ala Glu Phe 
        355                 360                 365             


Phe Arg Gly Lys Gly Ala Ser Val Val Arg Met Glu Glu Leu Ser Gly 
    370                 375                 380                 


Leu Lys Glu Lys Asp Asn Phe Phe Ser Ser Tyr Leu Arg Met Tyr Trp 
385                 390                 395                 400 


Asn Tyr Gly Gln Leu Gln Gln Ile Ile Glu Asn Lys Leu Lys Glu Tyr 
                405                 410                 415     


Gly Ile Lys Val Asn Tyr Val Ser Pro Lys Asp Thr Ser Lys Lys Cys 
            420                 425                 430         


His Ser Cys Thr His Ile Asn Glu Phe Phe Thr Phe Glu Tyr Arg Gln 
        435                 440                 445             


Lys Asn Asn Phe Pro Leu Phe Lys Cys Glu Lys Cys Gly Val Glu Cys 
    450                 455                 460                 


Ser Ala Asp Tyr Asn Ala Ala Lys Asn Met Ala Ile Ala 
465                 470                 475         


<210>  30
<211>  1293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  30

Met Arg Thr Met Val Thr Phe Glu Asp Phe Thr Lys Gln Tyr Gln Val 
1               5                   10                  15      


Ser Lys Thr Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu 
            20                  25                  30          


Asn Met Lys Arg Asp Gly Ile Ile Ser Val Asp Arg Gln Arg Asn Glu 
        35                  40                  45              


Asp Tyr Gln Lys Ala Lys Gly Ile Leu Asp Lys Leu Tyr Lys Tyr Ile 
    50                  55                  60                  


Leu Asp Phe Thr Met Glu Thr Val Val Ile Asp Trp Glu Ala Leu Ala 
65                  70                  75                  80  


Thr Ala Thr Glu Glu Phe Arg Lys Ser Lys Asp Lys Lys Thr Tyr Glu 
                85                  90                  95      


Lys Val Gln Ser Lys Ile Arg Thr Ala Leu Leu Glu His Val Lys Lys 
            100                 105                 110         


Gln Lys Val Gly Thr Glu Asp Leu Phe Lys Gly Met Phe Ser Ser Lys 
        115                 120                 125             


Ile Ile Thr Gly Glu Val Leu Ala Ala Phe Pro Glu Ile Arg Leu Ser 
    130                 135                 140                 


Asp Glu Glu Asn Leu Ile Leu Glu Lys Phe Lys Asp Phe Thr Thr Tyr 
145                 150                 155                 160 


Phe Thr Gly Phe Phe Glu Asn Arg Lys Asn Val Phe Thr Asp Glu Ala 
                165                 170                 175     


Leu Ser Thr Ser Phe Thr Tyr Arg Leu Val Asn Asp Asn Phe Ile Lys 
            180                 185                 190         


Phe Phe Asp Asn Cys Ile Val Phe Lys Asn Val Val Asn Ile Ser Pro 
        195                 200                 205             


His Met Ala Lys Ser Leu Glu Thr Cys Ala Ser Asp Leu Gly Ile Phe 
    210                 215                 220                 


Pro Gly Val Ser Leu Glu Glu Val Phe Ser Ile Ser Phe Tyr Asn Arg 
225                 230                 235                 240 


Leu Leu Thr Gln Thr Gly Ile Asp Gln Phe Asn Gln Leu Leu Gly Gly 
                245                 250                 255     


Ile Ser Gly Lys Glu Gly Glu His Lys Gln Gln Gly Leu Asn Glu Ile 
            260                 265                 270         


Ile Asn Leu Ala Met Gln Gln Asn Leu Glu Val Lys Glu Val Leu Lys 
        275                 280                 285             


Asn Lys Ala His Arg Phe Thr Pro Leu Phe Lys Gln Ile Leu Ser Asp 
    290                 295                 300                 


Arg Ser Thr Met Ser Phe Ile Pro Asp Ala Phe Ala Asp Asp Asp Glu 
305                 310                 315                 320 


Val Leu Ser Ala Val Asp Ala Tyr Arg Lys Tyr Leu Ser Glu Lys Asn 
                325                 330                 335     


Ile Gly Asp Arg Ala Phe Gln Leu Ile Ser Asp Met Glu Ala Tyr Ser 
            340                 345                 350         


Pro Glu Leu Met Arg Ile Gly Gly Lys Tyr Val Ser Val Leu Ser Gln 
        355                 360                 365             


Leu Leu Phe Tyr Ser Trp Ser Glu Ile Arg Asp Gly Val Lys Ala Tyr 
    370                 375                 380                 


Lys Glu Ser Leu Ile Thr Gly Lys Lys Thr Lys Lys Glu Leu Glu Asn 
385                 390                 395                 400 


Ile Asp Lys Glu Ile Lys Tyr Gly Val Thr Leu Gln Glu Ile Lys Glu 
                405                 410                 415     


Ala Leu Pro Lys Lys Asp Ile Tyr Glu Glu Val Lys Lys Tyr Ala Met 
            420                 425                 430         


Ser Val Val Lys Asp Tyr His Ala Gly Leu Ala Glu Pro Leu Pro Glu 
        435                 440                 445             


Lys Ile Glu Thr Asp Asp Glu Arg Ala Ser Ile Lys His Ile Met Asp 
    450                 455                 460                 


Ser Met Leu Gly Leu Tyr Arg Phe Leu Glu Tyr Phe Ser His Asp Ser 
465                 470                 475                 480 


Ile Glu Asp Thr Asp Pro Val Phe Gly Glu Cys Leu Asp Thr Ile Leu 
                485                 490                 495     


Asp Asp Met Asn Glu Thr Val Pro Leu Tyr Asn Lys Val Arg Asn Phe 
            500                 505                 510         


Ser Thr Arg Lys Val Tyr Ser Thr Glu Lys Phe Lys Leu Asn Phe Asn 
        515                 520                 525             


Asn Ser Ser Leu Ala Asn Gly Trp Asp Lys Asn Lys Glu Gln Ala Asn 
    530                 535                 540                 


Gly Ala Ile Leu Leu Arg Lys Glu Gly Glu Tyr Phe Leu Gly Ile Phe 
545                 550                 555                 560 


Asn Ser Lys Asn Lys Pro Lys Leu Val Ser Asp Gly Gly Ala Gly Ile 
                565                 570                 575     


Gly Tyr Glu Lys Met Ile Tyr Lys Gln Phe Pro Asp Phe Lys Lys Met 
            580                 585                 590         


Leu Pro Lys Cys Thr Ile Ser Leu Lys Asp Thr Lys Ala His Phe Gln 
        595                 600                 605             


Lys Ser Asp Glu Asp Phe Thr Leu Gln Thr Asp Lys Phe Glu Lys Ser 
    610                 615                 620                 


Ile Val Ile Thr Lys Gln Ile Tyr Asp Leu Gly Thr Gln Thr Val Asn 
625                 630                 635                 640 


Gly Lys Lys Lys Phe Gln Val Asp Tyr Pro Arg Leu Thr Gly Asp Met 
                645                 650                 655     


Glu Gly Tyr Arg Ala Ala Leu Lys Glu Trp Ile Asp Phe Gly Lys Glu 
            660                 665                 670         


Phe Ile Gln Ala Tyr Thr Ser Thr Ala Ile Tyr Asp Thr Ser Leu Phe 
        675                 680                 685             


Arg Asp Ser Ser Asp Tyr Pro Asp Leu Pro Ser Phe Tyr Lys Asp Val 
    690                 695                 700                 


Asp Asn Ile Cys Tyr Lys Leu Thr Phe Glu Trp Ile Pro Asp Ala Val 
705                 710                 715                 720 


Ile Asp Asp Cys Ile Asp Asp Gly Ser Leu Tyr Leu Phe Lys Leu His 
                725                 730                 735     


Asn Lys Asp Phe Ser Ser Gly Ser Ile Gly Lys Pro Asn Leu His Thr 
            740                 745                 750         


Leu Tyr Trp Lys Ala Leu Phe Glu Glu Glu Asn Leu Ser Asp Val Val 
        755                 760                 765             


Val Lys Leu Asn Gly Gln Ala Glu Leu Phe Tyr Arg Pro Lys Ser Leu 
    770                 775                 780                 


Thr Arg Pro Val Val His Glu Glu Gly Glu Val Ile Ile Asn Lys Thr 
785                 790                 795                 800 


Thr Ser Thr Gly Leu Pro Val Pro Asp Asp Val Tyr Val Glu Leu Ser 
                805                 810                 815     


Lys Phe Val Arg Asn Gly Lys Lys Gly Asn Leu Thr Asp Lys Ala Lys 
            820                 825                 830         


Asn Trp Leu Asp Lys Val Thr Val Arg Lys Met Pro His Ala Ile Thr 
        835                 840                 845             


Lys Asp Arg Arg Phe Thr Val Asp Lys Phe Phe Phe His Val Pro Ile 
    850                 855                 860                 


Thr Leu Asn Tyr Lys Ala Asp Ser Ser Pro Tyr Arg Phe Asn Asp Phe 
865                 870                 875                 880 


Val Arg Gln Tyr Ile Lys Asp Cys Ser Asp Val Lys Ile Ile Gly Ile 
                885                 890                 895     


Asp Arg Gly Glu Arg Asn Leu Ile Tyr Ala Val Val Ile Asp Gly Lys 
            900                 905                 910         


Gly Asn Ile Ile Glu Gln Arg Ser Phe Asn Thr Val Gly Thr Tyr Asn 
        915                 920                 925             


Tyr Gln Glu Lys Leu Glu Gln Lys Glu Lys Glu Arg Gln Thr Ala Arg 
    930                 935                 940                 


Gln Asp Trp Ala Thr Val Thr Lys Ile Lys Asp Leu Lys Lys Gly Tyr 
945                 950                 955                 960 


Leu Ser Ala Val Val His Glu Leu Ser Lys Met Ile Val Lys Tyr Lys 
                965                 970                 975     


Ala Ile Val Ala Leu Glu Asn Leu Asn Val Gly Phe Lys Arg Met Arg 
            980                 985                 990         


Gly Gly Ile Ala Glu Arg Ser Val  Tyr Gln Gln Phe Glu  Lys Ala Leu 
        995                 1000                 1005             


Ile Asp  Lys Leu Asn Tyr Leu  Val Phe Lys Asp Glu  Glu Gln Ser 
    1010                 1015                 1020             


Gly Tyr  Gly Gly Val Leu Asn  Ala Tyr Gln Leu Thr  Asp Lys Phe 
    1025                 1030                 1035             


Glu Ser  Phe Ser Lys Met Gly  Gln Gln Thr Gly Phe  Leu Phe Tyr 
    1040                 1045                 1050             


Val Pro  Ala Ala Tyr Thr Ser  Lys Ile Asp Pro Leu  Thr Gly Phe 
    1055                 1060                 1065             


Ile Asn  Pro Phe Ser Trp Lys  His Val Lys Asn Arg  Glu Asp Arg 
    1070                 1075                 1080             


Arg Asn  Phe Leu Asn Leu Phe  Ser Lys Leu Tyr Tyr  Asp Val Asn 
    1085                 1090                 1095             


Thr His  Asp Phe Val Leu Ala  Tyr His His Ser Asn  Lys Asp Ser 
    1100                 1105                 1110             


Lys Tyr  Thr Ile Lys Gly Asn  Trp Glu Ile Ala Asp  Trp Asp Ile 
    1115                 1120                 1125             


Leu Ile  Gln Glu Asn Lys Glu  Val Phe Gly Lys Thr  Gly Thr Pro 
    1130                 1135                 1140             


Tyr Cys  Val Gly Lys Arg Ile  Val Tyr Met Asp Asp  Ser Thr Thr 
    1145                 1150                 1155             


Gly His  Asn Arg Met Cys Ala  Tyr Tyr Pro His Thr  Glu Leu Lys 
    1160                 1165                 1170             


Lys Leu  Leu Ser Glu Tyr Gly  Ile Glu Tyr Thr Ser  Gly Gln Asp 
    1175                 1180                 1185             


Leu Leu  Lys Ile Ile Gln Glu  Phe Asp Asp Asp Lys  Leu Val Lys 
    1190                 1195                 1200             


Gly Leu  Phe Tyr Ile Ile Lys  Ala Ala Leu Gln Met  Arg Asn Ser 
    1205                 1210                 1215             


Asn Ser  Glu Thr Gly Glu Asp  Tyr Ile Ser Ser Pro  Ile Glu Gly 
    1220                 1225                 1230             


Arg Pro  Gly Ile Cys Phe Asp  Ser Arg Ala Glu Ala  Asp Thr Leu 
    1235                 1240                 1245             


Pro Tyr  Asp Ala Asp Ala Asn  Gly Ala Phe His Ile  Ala Met Lys 
    1250                 1255                 1260             


Gly Leu  Leu Leu Thr Glu Arg  Ile Arg Asn Asp Asp  Lys Leu Ala 
    1265                 1270                 1275             


Ile Ser  Asn Glu Glu Trp Leu  Asn Tyr Ile Gln Glu  Met Arg Gly 
    1280                 1285                 1290             


<210>  31
<211>  1228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  31

Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His 
    1220                 1225             


<210>  32
<211>  1286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  32

Met Thr Asn Phe Asp Asn Phe Thr Lys Lys Tyr Val Asn Ser Lys Thr 
1               5                   10                  15      


Ile Arg Leu Glu Ala Ile Pro Val Gly Lys Thr Leu Lys Asn Ile Glu 
            20                  25                  30          


Lys Met Gly Phe Ile Ala Ala Asp Arg Gln Arg Asp Glu Asp Tyr Gln 
        35                  40                  45              


Lys Ala Lys Ser Val Ile Asp His Ile Tyr Lys Ala Phe Met Asp Asp 
    50                  55                  60                  


Cys Leu Lys Asp Leu Phe Leu Asp Trp Asp Pro Leu Tyr Glu Ala Val 
65                  70                  75                  80  


Val Ala Cys Trp Arg Glu Arg Ser Pro Glu Gly Arg Gln Ala Leu Gln 
                85                  90                  95      


Ile Met Gln Ala Asp Tyr Arg Lys Lys Ile Ala Asp Arg Phe Arg Asn 
            100                 105                 110         


His Glu Leu Tyr Gly Ser Leu Phe Thr Lys Lys Ile Phe Asp Gly Ser 
        115                 120                 125             


Val Ala Gln Arg Leu Pro Asp Leu Glu Gln Ser Ala Glu Glu Lys Ser 
    130                 135                 140                 


Leu Leu Ser Asn Phe Asn Lys Phe Thr Ser Tyr Phe Arg Asp Phe Phe 
145                 150                 155                 160 


Asp Lys Arg Lys Arg Leu Phe Ser Asp Asp Glu Lys His Ser Ala Ile 
                165                 170                 175     


Ala Tyr Arg Leu Ile Asn Glu Asn Phe Leu Lys Phe Val Ala Asn Cys 
            180                 185                 190         


Glu Ala Phe Arg Arg Met Thr Glu Arg Val Pro Glu Leu Arg Glu Lys 
        195                 200                 205             


Leu Gln Asn Thr Gly Ser Leu Gln Val Tyr Asn Gly Leu Ala Leu Asp 
    210                 215                 220                 


Glu Val Phe Ser Ala Asp Phe Tyr Asn Gln Leu Ile Val Gln Lys Gln 
225                 230                 235                 240 


Ile Asp Leu Tyr Asn Gln Leu Ile Gly Gly Ile Ala Gly Glu Pro Gly 
                245                 250                 255     


Thr Pro Asn Ile Gln Gly Leu Asn Ala Thr Ile Asn Leu Ala Leu Gln 
            260                 265                 270         


Gly Asp Ser Ser Leu His Glu Lys Leu Ala Gly Ile Pro His Arg Phe 
        275                 280                 285             


Asn Pro Leu Tyr Lys Gln Ile Leu Ser Asp Val Ser Thr Leu Ser Phe 
    290                 295                 300                 


Val Pro Ser Ala Phe Gln Ser Asp Gly Glu Met Leu Ala Ala Val Arg 
305                 310                 315                 320 


Gly Phe Lys Val Gln Leu Glu Ser Gly Arg Val Leu Gln Asn Val Arg 
                325                 330                 335     


Arg Leu Phe Asn Gly Leu Glu Thr Glu Ala Asp Leu Ser Arg Val Tyr 
            340                 345                 350         


Val Asn Asn Ser Lys Leu Ala Ala Phe Ser Ser Met Phe Phe Gly Arg 
        355                 360                 365             


Trp Asn Leu Cys Ser Asp Ala Leu Phe Ala Trp Lys Lys Gly Lys Gln 
    370                 375                 380                 


Lys Lys Ile Thr Asn Lys Lys Leu Thr Glu Ile Lys Lys Trp Leu Lys 
385                 390                 395                 400 


Asn Ser Asp Ile Ala Ile Ala Glu Ile Gln Glu Ala Phe Gly Glu Asp 
                405                 410                 415     


Phe Pro Arg Gly Lys Ile Asn Glu Lys Ile Gln Ala Gln Ala Asp Ala 
            420                 425                 430         


Leu His Ser Gln Leu Ala Leu Pro Ile Pro Glu Asn Leu Lys Ala Leu 
        435                 440                 445             


Cys Ala Lys Asp Gly Leu Lys Ser Met Leu Asp Thr Val Leu Gly Leu 
    450                 455                 460                 


Tyr Arg Met Leu Gln Trp Phe Ile Val Gly Asp Asp Asn Glu Lys Asp 
465                 470                 475                 480 


Ser Asp Phe Tyr Phe Gly Leu Gly Lys Ile Leu Gly Ser Leu Asp Pro 
                485                 490                 495     


Val Leu Val Leu Tyr Asn Arg Val Arg Asn Tyr Ile Thr Lys Lys Pro 
            500                 505                 510         


Tyr Ser Leu Thr Lys Phe Arg Leu Asn Phe Asp Asn Ser Gln Leu Leu 
        515                 520                 525             


Asn Gly Trp Asp Glu Asn Asn Leu Asp Thr Asn Cys Ala Ser Ile Phe 
    530                 535                 540                 


Ile Lys Asp Gly Lys Tyr Tyr Leu Gly Ile Ser Asn Lys Asn Asn Arg 
545                 550                 555                 560 


Pro Gln Phe Asp Thr Val Ala Thr Ser Gly Lys Ser Gly Tyr Gln Arg 
                565                 570                 575     


Met Val Tyr Lys Gln Phe Ala Asn Trp Gly Arg Asp Leu Pro His Ser 
            580                 585                 590         


Thr Thr Gln Met Lys Lys Val Lys Lys His Phe Ser Ala Ser Asp Ala 
        595                 600                 605             


Asp Tyr Val Leu Asp Gly Asp Lys Phe Ile Arg Pro Leu Ile Ile Thr 
    610                 615                 620                 


Lys Glu Ile Phe Asp Leu Asn Asn Val Lys Phe Asn Gly Lys Lys Lys 
625                 630                 635                 640 


Leu Gln Val Asp Tyr Leu Arg Asn Thr Gly Asp Arg Glu Gly Tyr Thr 
                645                 650                 655     


His Ala Leu His Thr Trp Ile Asn Phe Ala Lys Asp Phe Cys Ala Cys 
            660                 665                 670         


Tyr Lys Ser Thr Ser Ile Tyr Asp Ile Ser Cys Leu Arg Pro Thr Asp 
        675                 680                 685             


Gln Tyr Asp Asn Leu Met Asp Phe Tyr Ala Asp Leu Gly Asn Leu Ser 
    690                 695                 700                 


His Arg Ile Val Trp Gln Thr Ile Pro Glu Glu Ala Ile Asp Asn Tyr 
705                 710                 715                 720 


Val Glu Gln Gly Gln Leu Phe Leu Phe Gln Leu Tyr Asn Lys Asp Phe 
                725                 730                 735     


Ala Pro Gly Ala Asp Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Lys 
            740                 745                 750         


Ala Val Phe Asn Pro Glu Asn Leu Glu Asp Val Val Val Lys Leu Asn 
        755                 760                 765             


Gly Lys Ala Glu Leu Phe Tyr Arg Pro Arg Ser Asn Met Asp Val Val 
    770                 775                 780                 


Arg His Lys Val Gly Glu Lys Leu Val Asn Arg Lys Leu Lys Asn Gly 
785                 790                 795                 800 


Leu Thr Leu Pro Ser Arg Leu His Glu Glu Ile Tyr Arg Tyr Val Asn 
                805                 810                 815     


Gly Thr Leu Asn Lys Asp Leu Ser Ala Asp Ala Arg Ser Val Leu Pro 
            820                 825                 830         


Leu Ala Val Val Arg Asp Val Gln His Glu Ile Ile Lys Asp Arg Arg 
        835                 840                 845             


Phe Thr Ala Asp Lys Phe Phe Phe His Ala Ser Leu Thr Phe Asn Phe 
    850                 855                 860                 


Lys Ser Ser Asp Lys Pro Val Gly Phe Asn Glu Asp Val Arg Glu Tyr 
865                 870                 875                 880 


Leu Arg Glu His Pro Asp Thr Tyr Val Val Gly Val Asp Arg Gly Glu 
                885                 890                 895     


Arg Asn Leu Ile Tyr Ile Val Val Ile Asp Pro Gln Gly Asn Ile Val 
            900                 905                 910         


Glu Gln Arg Ser Phe Asn Met Ile Asn Gly Ile Asp Tyr Trp Ser Leu 
        915                 920                 925             


Leu Asp Gln Lys Glu Lys Glu Arg Val Glu Ala Lys Gln Ala Trp Glu 
    930                 935                 940                 


Thr Val Gly Lys Ile Lys Asp Leu Lys Cys Gly Tyr Leu Ser Phe Leu 
945                 950                 955                 960 


Ile His Glu Ile Thr Lys Ile Ile Ile Lys Tyr His Ala Val Val Ile 
                965                 970                 975     


Leu Glu Asn Leu Ser Leu Gly Phe Lys Arg Val Arg Thr Gly Ile Ala 
            980                 985                 990         


Glu Lys Ala Val Tyr Gln Gln Phe  Glu Arg Met Leu Val  Thr Lys Leu 
        995                 1000                 1005             


Gly Tyr  Val Val Phe Lys Asp  Arg Ala Gly Lys Ala  Pro Gly Gly 
    1010                 1015                 1020             


Val Leu  Asn Ala Tyr Gln Leu  Thr Asp Asn Thr Arg  Thr Ala Glu 
    1025                 1030                 1035             


Asn Thr  Gly Ile Gln Asn Gly  Phe Leu Phe Tyr Val  Pro Ala Ala 
    1040                 1045                 1050             


Phe Thr  Ser Arg Val Asp Pro  Ala Thr Gly Phe Phe  Asp Phe Tyr 
    1055                 1060                 1065             


Asp Trp  Gly Lys Ile Lys Thr  Ala Thr Asp Lys Lys  Asn Phe Ile 
    1070                 1075                 1080             


Ala Gly  Phe Asn Ser Val Arg  Tyr Glu Arg Ser Thr  Gly Asp Phe 
    1085                 1090                 1095             


Ile Val  His Val Gly Ala Lys  Asn Leu Ala Val Arg  Arg Val Ala 
    1100                 1105                 1110             


Glu Asp  Val Arg Thr Glu Trp  Asp Ile Val Ile Glu  Ala Asn Val 
    1115                 1120                 1125             


Arg Lys  Met Gly Ile Asp Gly  Asn Ser Tyr Ile Ser  Gly Lys Arg 
    1130                 1135                 1140             


Ile Arg  Tyr Arg Ser Gly Glu  Gln Gly His Gly Gln  Tyr Glu Asn 
    1145                 1150                 1155             


His Leu  Pro Cys Gln Glu Leu  Ile Arg Ala Leu Gln  Gln Tyr Gly 
    1160                 1165                 1170             


Ile Gln  Tyr Glu Thr Gly Lys  Asp Ile Leu Pro Ala  Ile Leu Gln 
    1175                 1180                 1185             


Gln Asp  Asp Ala Lys Leu Thr  Asp Thr Val Phe Asp  Val Phe Arg 
    1190                 1195                 1200             


Leu Ala  Leu Gln Met Arg Asn  Thr Ser Ala Glu Thr  Gly Glu Asp 
    1205                 1210                 1215             


Tyr Phe  Asn Ser Val Val Arg  Asp Arg Ser Gly Arg  Cys Phe Asp 
    1220                 1225                 1230             


Thr Arg  Arg Ala Glu Ala Ala  Met Pro Lys Glu Ala  Asp Ala Asn 
    1235                 1240                 1245             


Asp Ala  Tyr His Ile Ala Leu  Lys Gly Leu Phe Val  Leu Glu Lys 
    1250                 1255                 1260             


Leu Arg  Lys Gly Glu Ser Ile  Gly Ile Lys Asn Thr  Glu Trp Leu 
    1265                 1270                 1275             


Arg Tyr  Val Gln Gln Arg His  Ser 
    1280                 1285     


<210>  33
<211>  1272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  33

Met Thr Pro Ile Phe Cys Asn Phe Val Val Tyr Gln Ile Met Leu Phe 
1               5                   10                  15      


Asn Asn Asn Ile Asn Ile Asn Val Lys Thr Met Asn Lys Lys His Leu 
            20                  25                  30          


Ser Asp Phe Thr Asn Leu Phe Pro Val Ser Lys Thr Leu Arg Phe Arg 
        35                  40                  45              


Leu Glu Pro Gln Gly Lys Thr Met Glu Asn Ile Val Lys Ala Gln Thr 
    50                  55                  60                  


Ile Glu Thr Asp Glu Glu Arg Ser His Asp Tyr Glu Lys Thr Lys Glu 
65                  70                  75                  80  


Tyr Ile Asp Asp Tyr His Arg Gln Phe Ile Asp Asp Thr Leu Asp Lys 
                85                  90                  95      


Phe Ala Phe Lys Val Glu Ser Thr Gly Asn Asn Asp Ser Leu Gln Asp 
            100                 105                 110         


Tyr Leu Asp Ala Tyr Leu Ser Ala Asn Asp Asn Arg Thr Lys Gln Thr 
        115                 120                 125             


Glu Glu Ile Gln Thr Asn Leu Arg Lys Ala Ile Val Ser Ala Phe Lys 
    130                 135                 140                 


Met Gln Pro Gln Phe Asn Leu Leu Phe Lys Lys Glu Met Val Lys His 
145                 150                 155                 160 


Leu Leu Pro Gln Phe Val Asp Thr Asp Asp Lys Lys Arg Ile Val Ala 
                165                 170                 175     


Lys Phe Asn Asp Phe Thr Thr Tyr Phe Thr Gly Phe Phe Thr Asn Arg 
            180                 185                 190         


Glu Asn Met Tyr Ser Asp Glu Ala Lys Ser Thr Ser Ile Ala Tyr Arg 
        195                 200                 205             


Ile Val Asn Gln Asn Leu Ile Lys Phe Val Glu Asn Met Leu Thr Phe 
    210                 215                 220                 


Lys Ser His Ile Leu Pro Ile Leu Pro Gln Glu Gln Leu Ala Thr Leu 
225                 230                 235                 240 


Tyr Asp Asp Phe Lys Glu Tyr Leu Asn Val Ala Ser Ile Ala Glu Met 
                245                 250                 255     


Phe Glu Leu Asp His Phe Ser Ile Val Leu Thr Gln Arg Gln Ile Glu 
            260                 265                 270         


Val Tyr Asn Ser Val Ile Gly Gly Arg Lys Asp Glu Asn Asn Lys Gln 
        275                 280                 285             


Ile Lys Pro Gly Leu Asn Gln Tyr Ile Asn Gln His Asn Gln Ala Val 
    290                 295                 300                 


Lys Asp Lys Ser Ala Arg Leu Pro Leu Leu Lys Pro Leu Phe Asn Gln 
305                 310                 315                 320 


Ile Leu Ser Glu Lys Ala Gly Val Ser Phe Leu Pro Lys Gln Phe Lys 
                325                 330                 335     


Ser Ala Ser Glu Val Val Lys Ser Leu Asn Glu Ala Tyr Ala Glu Leu 
            340                 345                 350         


Ser Pro Val Leu Ala Ala Ile Gln Asp Val Val Thr Asn Ile Thr Asp 
        355                 360                 365             


Tyr Asp Cys Asn Gly Ile Phe Ile Lys Asn Asp Leu Gly Leu Thr Asp 
    370                 375                 380                 


Ile Ala Gln Arg Phe Tyr Gly Asn Tyr Asp Ala Val Lys Arg Gly Leu 
385                 390                 395                 400 


Arg Asn Gln Tyr Glu Leu Glu Thr Pro Met His Asn Gly Gln Lys Ala 
                405                 410                 415     


Glu Lys Tyr Glu Glu Gln Val Ala Lys His Leu Lys Ser Ile Glu Ser 
            420                 425                 430         


Val Ser Leu Ala Gln Ile Asn Gln Val Val Thr Asp Gly Gly Asp Ile 
        435                 440                 445             


Cys Asp Tyr Phe Lys Ala Phe Gly Ala Thr Asp Asp Gly Asp Ile Gln 
    450                 455                 460                 


Arg Glu Asn Leu Leu Ala Ser Ile Asn Asn Ala His Thr Ala Ile Ser 
465                 470                 475                 480 


Pro Val Leu Asn Lys Glu Asn Ala Asn Asp Asn Glu Leu Arg Lys Asn 
                485                 490                 495     


Thr Met Leu Ile Lys Asp Leu Leu Asp Ala Ile Lys Arg Leu Gln Trp 
            500                 505                 510         


Phe Ala Lys Pro Leu Leu Gly Ala Gly Asp Glu Thr Asn Lys Asp Gln 
        515                 520                 525             


Val Phe Tyr Gly Lys Phe Glu Pro Leu Tyr Asn Gln Leu Asp Glu Thr 
    530                 535                 540                 


Ile Ser Pro Leu Tyr Asp Lys Val Arg Ser Tyr Leu Thr Lys Lys Pro 
545                 550                 555                 560 


Tyr Ser Leu Asp Lys Phe Lys Ile Asn Phe Glu Lys Ser Asn Leu Leu 
                565                 570                 575     


Gly Gly Trp Asp Pro Gly Ala Asp Arg Lys Tyr Gln Tyr Asn Ala Val 
            580                 585                 590         


Ile Leu Arg Lys Asp Asn Asp Phe Tyr Leu Gly Ile Met Arg Asp Glu 
        595                 600                 605             


Ala Thr Ser Lys Arg Lys Cys Ile Gln Val Leu Asp Cys Asn Asp Glu 
    610                 615                 620                 


Gly Leu Asp Glu Asn Phe Glu Lys Val Glu Tyr Lys Gln Ile Lys Pro 
625                 630                 635                 640 


Ser Gln Asn Met Pro Arg Cys Ala Phe Ala Lys Lys Glu Cys Glu Glu 
                645                 650                 655     


Asn Ala Asp Ile Met Glu Leu Lys Arg Lys Lys Asn Ala Lys Ser Tyr 
            660                 665                 670         


Asn Thr Asn Lys Asp Asp Lys Asn Ala Leu Ile Arg His Tyr Gln Arg 
        675                 680                 685             


Tyr Leu Asp Arg Thr Tyr Pro Glu Phe Gly Phe Val Tyr Lys Asp Ala 
    690                 695                 700                 


Asp Glu Tyr Asp Thr Val Lys Ala Phe Thr Asp Ser Met Asp Ser Gln 
705                 710                 715                 720 


Asp Tyr Lys Leu Ser Phe Leu Gln Val Ser Glu Thr Gly Leu Asn Lys 
                725                 730                 735     


Leu Val Asp Glu Gly Asp Leu Tyr Leu Phe Lys Ile Thr Asn Lys Asp 
            740                 745                 750         


Phe Ser Ser Tyr Ala Lys Gly Arg Pro Asn Leu His Thr Ile Tyr Trp 
        755                 760                 765             


Arg Met Leu Phe Asp Pro Lys Asn Leu Ala Asn Val Val Tyr Lys Leu 
    770                 775                 780                 


Glu Gly Lys Ala Glu Val Phe Phe Arg Arg Lys Ser Leu Ala Ser Thr 
785                 790                 795                 800 


Thr Thr His Lys Ala Lys Gln Ala Ile Lys Asn Lys Ser Arg Tyr Asn 
                805                 810                 815     


Glu Ala Val Lys Pro Gln Ser Thr Phe Asp Tyr Asp Ile Ile Lys Asp 
            820                 825                 830         


Arg Arg Phe Thr Ala Asp Lys Phe Glu Phe His Val Pro Ile Lys Met 
        835                 840                 845             


Asn Phe Lys Ala Ala Gly Trp Asn Ser Thr Arg Leu Thr Asn Glu Val 
    850                 855                 860                 


Arg Glu Phe Ile Lys Ser Gln Gly Val Arg His Ile Ile Gly Ile Asp 
865                 870                 875                 880 


Arg Gly Glu Arg His Leu Leu Tyr Leu Thr Met Ile Asp Met Asp Gly 
                885                 890                 895     


Asn Ile Val Lys Gln Cys Ser Leu Asn Ala Pro Ala Gln Asp Asn Ala 
            900                 905                 910         


Arg Ala Ser Glu Val Asp Tyr His Gln Leu Leu Asp Ser Lys Glu Ala 
        915                 920                 925             


Asp Arg Leu Ala Ala Arg Arg Asn Trp Gly Thr Ile Glu Asn Ile Lys 
    930                 935                 940                 


Glu Leu Lys Gln Gly Tyr Leu Ser Gln Val Val His Leu Leu Ala Thr 
945                 950                 955                 960 


Met Met Val Asp Asn Asp Ala Ile Leu Val Leu Glu Asn Leu Asn Ala 
                965                 970                 975     


Gly Phe Met Arg Gly Arg Gln Lys Val Glu Lys Ser Val Tyr Gln Lys 
            980                 985                 990         


Phe Glu Lys Met Leu Ile Asp Lys  Leu Asn Tyr Ile Val  Asp Lys Gly 
        995                 1000                 1005             


Gln Ser  Pro Asp Lys Pro Thr  Gly Ala Leu His Ala  Val Gln Leu 
    1010                 1015                 1020             


Thr Gly  Leu Tyr Ser Asp Phe  Asn Lys Ser Asn Met  Lys Arg Ala 
    1025                 1030                 1035             


Asn Val  Arg Gln Cys Gly Phe  Val Phe Tyr Ile Pro  Ala Trp Asn 
    1040                 1045                 1050             


Thr Ser  Lys Ile Asp Pro Val  Thr Gly Phe Val Asn  Leu Phe Asp 
    1055                 1060                 1065             


Thr His  Leu Ser Ser Met Gly  Glu Ile Lys Ala Phe  Phe Ser Lys 
    1070                 1075                 1080             


Phe Asp  Ser Ile Arg Tyr Asn  Gln Asp Lys Gly Trp  Phe Glu Phe 
    1085                 1090                 1095             


Lys Phe  Asp Tyr Ser Arg Phe  Thr Thr Arg Ala Glu  Gly Cys Arg 
    1100                 1105                 1110             


Thr Gln  Trp Thr Val Cys Thr  Tyr Gly Glu Arg Ile  Trp Thr His 
    1115                 1120                 1125             


Arg Ser  Lys Asn Gln Asn Asn  Gln Phe Val Asn Asp  Thr Val Asn 
    1130                 1135                 1140             


Val Thr  Gln Gln Met Leu Gln  Leu Leu Gln Asp Cys  Gly Ile Asp 
    1145                 1150                 1155             


Pro Asn  Gly Asn Leu Lys Glu  Ala Ile Ala Asn Ile  Asp Ser Lys 
    1160                 1165                 1170             


Lys Ser  Leu Glu Thr Leu Leu  His Leu Phe Lys Leu  Thr Val Gln 
    1175                 1180                 1185             


Met Arg  Asn Ser Val Thr Gly  Ser Glu Val Asp Tyr  Met Ile Ser 
    1190                 1195                 1200             


Pro Val  Ala Asp Glu Arg Gly  His Phe Phe Asp Ser  Arg Glu Ser 
    1205                 1210                 1215             


Asp Glu  His Leu Pro Ala Asn  Ala Asp Ala Asn Gly  Ala Phe Asn 
    1220                 1225                 1230             


Ile Ala  Arg Lys Gly Leu Met  Val Val Arg Gln Ile  Met Ala Thr 
    1235                 1240                 1245             


Asp Asp  Val Ser Lys Ile Lys  Phe Ala Val Ser Asn  Lys Asp Trp 
    1250                 1255                 1260             


Leu Arg  Phe Ala Gln His Ile  Asp Asp 
    1265                 1270         


<210>  34
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  34

Val Lys Ile Ser Lys Thr Leu Ser Leu Arg Ile Ile Arg Pro Tyr Tyr 
1               5                   10                  15      


Thr Pro Glu Val Glu Ser Ala Ile Lys Ala Glu Lys Asp Lys Arg Glu 
            20                  25                  30          


Ala Gln Gly Gln Thr Arg Asn Leu Asp Ala Lys Phe Phe Asn Glu Leu 
        35                  40                  45              


Lys Lys Lys His Pro Gln Ile Ile Leu Ser Gly Glu Phe Tyr Ser Leu 
    50                  55                  60                  


Leu Phe Glu Met Gln Arg Gln Leu Thr Ser Ile Tyr Asn Arg Ala Met 
65                  70                  75                  80  


Ser Ser Leu Tyr His Lys Ile Ile Val Glu Gly Glu Lys Thr Ser Thr 
                85                  90                  95      


Ser Lys Ala Leu Ser Asp Ile Gly Tyr Asp Glu Cys Lys Ser Val Phe 
            100                 105                 110         


Pro Ser Tyr Ile Ala Leu Gly Leu Arg Gln Lys Ile Gln Ser Asn Phe 
        115                 120                 125             


Arg Arg Lys Glu Leu Lys Gly Phe Arg Met Ala Val Pro Thr Ala Lys 
    130                 135                 140                 


Ser Asp Lys Phe Pro Ile Pro Ile Tyr Lys Gln Val Asp Asp Gly Lys 
145                 150                 155                 160 


Gly Gly Phe Lys Ile Ser Glu Asn Lys Glu Gly Asp Phe Ile Val Glu 
                165                 170                 175     


Leu Pro Leu Val Glu Tyr Thr Ala Glu Asp Val Lys Thr Ala Lys Gly 
            180                 185                 190         


Lys Phe Thr Lys Ile Asn Ile Ser Lys Pro Pro Lys Ile Lys Asn Ile 
        195                 200                 205             


Pro Val Ile Leu Ser Thr Leu Arg Arg Lys Gln Ser Gly Gln Trp Phe 
    210                 215                 220                 


Ser Asp Glu Gly Thr Asn Ala Glu Ile Arg Arg Val Ile Ser Gly Glu 
225                 230                 235                 240 


Tyr Lys Val Ser Trp Ile Glu Val Val Arg Arg Thr Arg Phe Gly Lys 
                245                 250                 255     


His Asp Asp Trp Phe Leu Asn Ile Val Ile Lys Tyr Asp Lys Thr Glu 
            260                 265                 270         


Asp Gly Leu Asp Pro Glu Val Val Gly Gly Ile Asp Val Gly Val Ser 
        275                 280                 285             


Thr Pro Leu Val Cys Ala Val Asn Asn Ser Leu Asp Arg Tyr Phe Val 
    290                 295                 300                 


Lys Ser Ser Asp Ile Ile Ala Phe Lys Lys Arg Ala Met Ala Arg Arg 
305                 310                 315                 320 


Arg Thr Leu Leu Arg Gln Asn Arg Phe Lys Arg Ser Gly His Gly Ser 
                325                 330                 335     


Lys Ser Lys Leu Glu Pro Ile Thr Ile Leu Thr Glu Lys Asn Glu Arg 
            340                 345                 350         


Phe Lys Lys Ser Ile Met Gln Arg Trp Ala Lys Glu Val Ala Glu Phe 
        355                 360                 365             


Phe Lys Gly Glu Arg Ala Ser Val Val Gln Met Glu Glu Leu Ser Gly 
    370                 375                 380                 


Leu Lys Glu Lys Asp Asn Phe Phe Gly Ser Tyr Leu Arg Met Tyr Trp 
385                 390                 395                 400 


Asn Tyr Gly Gln Leu Gln Gln Ile Ile Glu Asn Lys Leu Lys Glu Tyr 
                405                 410                 415     


Gly Ile Lys Val Asn Tyr Val Ser Pro Lys Asp Thr Ser Lys Lys Cys 
            420                 425                 430         


His Ser Cys Gly Tyr Ile Asn Glu Phe Phe Thr Phe Glu Phe Arg Gln 
        435                 440                 445             


Lys Asn Asn Phe Pro Leu Phe Lys Cys Lys Lys Cys Gly Val Glu Cys 
    450                 455                 460                 


Asn Ala Asp Tyr Asn Ala Ala Lys Asn Ile Ala Ile Ala 
465                 470                 475         


<210>  35
<211>  1281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  35

Met Leu Lys Ser Tyr Asp Tyr Phe Thr Lys Leu Tyr Ser Leu Gln Lys 
1               5                   10                  15      


Thr Leu Arg Phe Glu Leu Lys Pro Ile Gly Lys Thr Leu Glu His Ile 
            20                  25                  30          


Lys Asn Ser Gly Ile Ile Glu Ser Asp Glu Thr Leu Glu Glu Gln Tyr 
        35                  40                  45              


Ala Ile Val Lys Asn Ile Ile Asp Lys Leu His Arg Lys His Ile Asp 
    50                  55                  60                  


Glu Ala Leu Ser Leu Val Asp Phe Thr Lys His Leu Asp Thr Leu Lys 
65                  70                  75                  80  


Thr Phe Gln Glu Leu Tyr Leu Lys Arg Gly Lys Thr Asp Lys Glu Lys 
                85                  90                  95      


Glu Glu Leu Glu Lys Leu Ser Ala Asp Leu Arg Lys Leu Ile Val Ser 
            100                 105                 110         


Tyr Leu Lys Gly Asn Val Lys Glu Lys Thr Gln His Asn Leu Asn Pro 
        115                 120                 125             


Ile Lys Glu Arg Phe Glu Ile Leu Phe Gly Lys Glu Leu Phe Thr Asn 
    130                 135                 140                 


Glu Glu Phe Phe Leu Leu Ala Glu Asn Glu Lys Glu Lys Lys Ala Ile 
145                 150                 155                 160 


Gln Ala Phe Lys Gly Phe Thr Thr Tyr Phe Lys Gly Phe Gln Glu Asn 
                165                 170                 175     


Arg Lys Asn Met Tyr Ser Glu Glu Gly Asn Ser Thr Ser Ile Ala Tyr 
            180                 185                 190         


Arg Ile Ile Asn Glu Asn Leu Pro Leu Phe Ile Glu Asn Ile Ala Arg 
        195                 200                 205             


Phe Gln Lys Val Met Ser Thr Ile Glu Lys Thr Thr Ile Lys Lys Leu 
    210                 215                 220                 


Glu Gln Asn Leu Lys Thr Glu Leu Lys Lys His Asn Leu Pro Gly Ile 
225                 230                 235                 240 


Phe Thr Ile Glu Tyr Phe Asn Asn Val Leu Thr Gln Glu Gly Ile Ser 
                245                 250                 255     


Arg Tyr Asn Thr Ile Ile Gly Gly Lys Thr Thr His Glu Gly Val Lys 
            260                 265                 270         


Ile Gln Gly Leu Asn Glu Ile Ile Asn Leu Tyr Asn Gln Gln Ser Lys 
        275                 280                 285             


Asp Val Lys Leu Pro Ile Leu Lys Pro Leu His Lys Gln Ile Leu Ser 
    290                 295                 300                 


Glu Glu Tyr Ser Thr Ser Phe Lys Ile Lys Ala Phe Glu Asn Asp Asn 
305                 310                 315                 320 


Glu Val Leu Lys Ala Ile Asp Thr Phe Trp Asn Glu His Ile Glu Lys 
                325                 330                 335     


Ser Ile His Pro Val Thr Gly Asn Lys Phe Asn Ile Leu Ser Lys Ile 
            340                 345                 350         


Glu Asn Leu Cys Asp Gln Leu Gln Lys Tyr Lys Asp Lys Asp Leu Glu 
        355                 360                 365             


Lys Leu Phe Ile Glu Arg Lys Asn Leu Ser Thr Val Ser His Gln Val 
    370                 375                 380                 


Tyr Gly Gln Trp Asn Ile Ile Arg Asp Ala Leu Arg Met His Leu Glu 
385                 390                 395                 400 


Met Asn Asn Lys Asn Ile Lys Glu Lys Asp Ile Asp Lys Tyr Leu Asp 
                405                 410                 415     


Asn Asp Ala Phe Ser Trp Lys Glu Ile Lys Asp Ser Ile Lys Ile Tyr 
            420                 425                 430         


Lys Glu His Val Glu Asp Ala Lys Glu Leu Asn Glu Asn Gly Ile Ile 
        435                 440                 445             


Lys Tyr Phe Ser Ala Met Ser Ile Asn Glu Glu Asp Asp Glu Lys Glu 
    450                 455                 460                 


Tyr Ser Ile Ser Leu Ile Lys Asn Ile Asn Glu Lys Tyr Asn Asn Val 
465                 470                 475                 480 


Lys Ser Ile Leu Gln Glu Asp Arg Thr Gly Lys Ser Asp Leu His Gln 
                485                 490                 495     


Asp Lys Glu Lys Val Gly Ile Ile Lys Glu Phe Leu Asp Ser Leu Lys 
            500                 505                 510         


Gln Leu Gln Trp Phe Leu Arg Leu Leu Tyr Val Thr Val Pro Leu Asp 
        515                 520                 525             


Glu Lys Asp Tyr Glu Phe Tyr Asn Glu Leu Glu Val Tyr Tyr Glu Ala 
    530                 535                 540                 


Leu Leu Pro Leu Asn Ser Leu Tyr Asn Lys Val Arg Asn Tyr Met Thr 
545                 550                 555                 560 


Arg Lys Pro Tyr Ser Val Glu Lys Phe Lys Leu Asn Phe Asn Ser Pro 
                565                 570                 575     


Thr Leu Leu Asp Gly Trp Asp Lys Asn Lys Glu Thr Ala Asn Leu Ser 
            580                 585                 590         


Ile Ile Leu Arg Lys Asn Gly Lys Tyr Tyr Leu Gly Ile Met Asn Lys 
        595                 600                 605             


Glu Asn Asn Thr Ile Phe Glu Tyr Tyr Pro Gly Thr Lys Ser Asn Asp 
    610                 615                 620                 


Tyr Tyr Glu Lys Met Ile Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
625                 630                 635                 640 


Leu Pro Lys Val Phe Phe Ser Lys Lys Gly Leu Glu Tyr Tyr Asn Pro 
                645                 650                 655     


Pro Lys Glu Ile Leu Asn Ile Tyr Glu Lys Gly Glu Phe Lys Lys Asp 
            660                 665                 670         


Lys Ser Gly Asn Phe Lys Lys Glu Ser Leu His Thr Leu Ile Asp Phe 
        675                 680                 685             


Tyr Lys Glu Ala Ile Ala Lys Asn Glu Asp Trp Glu Val Phe Asn Phe 
    690                 695                 700                 


Lys Phe Lys Asn Thr Lys Glu Tyr Glu Asp Ile Ser Gln Phe Tyr Arg 
705                 710                 715                 720 


Asp Val Glu Glu Gln Gly Tyr Leu Ile Thr Phe Glu Lys Val Asp Ala 
                725                 730                 735     


Asn Tyr Val Asp Lys Leu Val Lys Glu Gly Lys Leu Tyr Leu Phe Gln 
            740                 745                 750         


Ile Tyr Asn Lys Asp Phe Ser Glu Asn Lys Lys Ser Lys Gly Asn Pro 
        755                 760                 765             


Asn Leu His Thr Ile Tyr Trp Lys Gly Leu Tyr Asp Ser Glu Asn Leu 
    770                 775                 780                 


Lys Asn Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Val Phe Tyr Arg 
785                 790                 795                 800 


Lys Lys Ser Ile Asp Tyr Pro Glu Glu Ile Tyr Asn His Gly His His 
                805                 810                 815     


Lys Glu Glu Leu Leu Gly Lys Phe Asn Tyr Pro Ile Ile Lys Asp Arg 
            820                 825                 830         


Arg Tyr Thr Gln Asp Lys Phe Leu Phe His Val Pro Ile Thr Met Asn 
        835                 840                 845             


Phe Ile Ser Lys Glu Glu Lys Arg Val Asn Gln Leu Ala Cys Glu Tyr 
    850                 855                 860                 


Leu Ser Ala Thr Lys Glu Asp Val His Ile Ile Gly Ile Asp Arg Gly 
865                 870                 875                 880 


Glu Arg His Leu Leu Tyr Leu Ser Leu Ile Asp Lys Glu Gly Asn Ile 
                885                 890                 895     


Lys Lys Gln Leu Ser Leu Asn Thr Ile Lys Asn Glu Asn Tyr Asp Lys 
            900                 905                 910         


Glu Ile Asp Tyr Arg Val Lys Leu Asp Glu Lys Glu Lys Lys Arg Asp 
        915                 920                 925             


Glu Ala Arg Lys Asn Trp Asp Val Ile Glu Asn Ile Lys Glu Leu Lys 
    930                 935                 940                 


Glu Gly Tyr Met Ser Gln Val Ile His Ile Ile Ala Lys Met Met Val 
945                 950                 955                 960 


Glu Glu Lys Ala Ile Leu Ile Met Glu Asp Leu Asn Ile Gly Phe Lys 
                965                 970                 975     


Arg Gly Arg Phe Lys Val Glu Lys Gln Val Tyr Gln Lys Phe Glu Lys 
            980                 985                 990         


Met Leu Ile Asp Lys Leu Asn Tyr  Leu Val Phe Lys Asn  Lys Asn Pro 
        995                 1000                 1005             


Leu Glu  Pro Gly Gly Ser Leu  Asn Ala Tyr Gln Leu  Thr Ser Lys 
    1010                 1015                 1020             


Phe Asp  Ser Phe Lys Lys Leu  Gly Lys Gln Ser Gly  Phe Ile Phe 
    1025                 1030                 1035             


Tyr Val  Pro Ser Ala Tyr Thr  Ser Lys Ile Asp Pro  Thr Thr Gly 
    1040                 1045                 1050             


Phe Tyr  Asn Phe Ile Gln Val  Asp Val Pro Asn Leu  Glu Lys Gly 
    1055                 1060                 1065             


Lys Glu  Phe Phe Ser Lys Phe  Glu Lys Ile Ile Tyr  Asn Thr Lys 
    1070                 1075                 1080             


Glu Asp  Tyr Phe Glu Phe His  Cys Lys Tyr Gly Lys  Phe Val Ser 
    1085                 1090                 1095             


Glu Pro  Lys Asn Lys Asp Asn  Asp Arg Lys Thr Lys  Glu Ser Leu 
    1100                 1105                 1110             


Thr Tyr  Tyr Asn Ala Ile Lys  Asp Thr Val Trp Val  Val Cys Ser 
    1115                 1120                 1125             


Thr Asn  His Glu Arg Tyr Lys  Ile Val Arg Asn Lys  Ala Gly Tyr 
    1130                 1135                 1140             


Tyr Glu  Ser His Pro Val Asp  Val Thr Lys Asn Leu  Lys Asp Ile 
    1145                 1150                 1155             


Phe Ser  Gln Ala Asn Ile Asn  Tyr Asn Glu Gly Lys  Asp Ile Lys 
    1160                 1165                 1170             


Pro Ile  Ile Ile Glu Ser Asn  Asn Ala Lys Leu Leu  Lys Ser Ile 
    1175                 1180                 1185             


Ala Glu  Gln Leu Lys Leu Ile  Leu Ala Met Arg Tyr  Asn Asn Gly 
    1190                 1195                 1200             


Lys His  Gly Asp Asp Glu Lys  Asp Tyr Ile Leu Ser  Pro Val Lys 
    1205                 1210                 1215             


Asn Lys  Gln Gly Lys Phe Phe  Cys Thr Leu Asp Gly  Asn Gln Thr 
    1220                 1225                 1230             


Leu Pro  Ile Asn Ala Asp Ala  Asn Gly Ala Tyr Asn  Ile Ala Leu 
    1235                 1240                 1245             


Lys Gly  Leu Leu Leu Ile Glu  Lys Ile Lys Lys Gln  Gln Gly Lys 
    1250                 1255                 1260             


Ile Lys  Asp Leu Tyr Ile Ser  Asn Leu Glu Trp Phe  Met Phe Met 
    1265                 1270                 1275             


Met Ser  Arg 
    1280     


<210>  36
<211>  809
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  36

Met Ile Lys Asn Pro Ser Asn Arg His Ser Leu Pro Lys Val Ile Ile 
1               5                   10                  15      


Ser Glu Val Asp His Glu Lys Ile Leu Glu Phe Lys Ile Lys Tyr Glu 
            20                  25                  30          


Lys Leu Ala Arg Leu Asp Arg Phe Glu Val Lys Ala Met His Tyr Glu 
        35                  40                  45              


Gly Lys Glu Ile Val Phe Asp Glu Val Leu Val Asn Gly Gly Leu Ile 
    50                  55                  60                  


Glu Val Glu Tyr Gln Asp Asp Asn Lys Thr Leu Phe Val Lys Val Gly 
65                  70                  75                  80  


Glu Lys Ser Tyr Ser Ile Arg Gly Lys Lys Val Gly Gly Lys Gln Arg 
                85                  90                  95      


Leu Leu Glu Asp Arg Val Ser Lys Thr Lys Val Gln Leu Glu Leu Ser 
            100                 105                 110         


Asp Gly Val Val Asp Asn Lys Gly Asn Leu Arg Lys Ser Arg Thr Glu 
        115                 120                 125             


Arg Glu Leu Ile Val Ala Asp Asn Ile Lys Leu Tyr Ser Gln Ile Val 
    130                 135                 140                 


Gly Arg Glu Val Thr Thr Thr Lys Glu Ile Tyr Leu Val Lys Arg Phe 
145                 150                 155                 160 


Leu Ala Tyr Arg Ser Asp Leu Leu Phe Tyr Tyr Ser Phe Val Asp Asn 
                165                 170                 175     


Phe Phe Lys Val Ala Gly Asn Glu Lys Glu Leu Trp Lys Ile Asn Phe 
            180                 185                 190         


Asp Asp Ala Thr Ser Ala Gln Phe Met Gly Tyr Ile Pro Phe Met Val 
        195                 200                 205             


Asn Asp Asn Leu Lys Asn Asp Asn Ala Tyr Leu Lys Asp Tyr Val Arg 
    210                 215                 220                 


Asn Asp Val Gln Ile Lys Asp Asp Leu Lys Lys Val Gln Thr Ile Phe 
225                 230                 235                 240 


Ser Ala Leu Arg His Thr Leu Leu His Phe Asn Tyr Glu Phe Phe Glu 
                245                 250                 255     


Lys Leu Phe Asn Gly Glu Asp Val Gly Phe Asp Phe Asp Ile Gly Phe 
            260                 265                 270         


Leu Asn Leu Leu Ile Glu Asn Ile Asp Lys Leu Asn Ile Asp Ala Lys 
        275                 280                 285             


Lys Glu Phe Ile Asp Asn Glu Lys Ile Arg Leu Phe Gly Glu Asn Leu 
    290                 295                 300                 


Ser Leu Ala Lys Val Tyr Arg Leu Tyr Ser Asp Ile Cys Val Asn Arg 
305                 310                 315                 320 


Val Gly Phe Asn Lys Phe Ile Asn Ser Met Leu Ile Lys Asp Gly Val 
                325                 330                 335     


Glu Asn Gln Val Leu Lys Ala Glu Phe Asn Arg Lys Phe Gly Gly Asn 
            340                 345                 350         


Ala Tyr Thr Ile Asp Ile His Ser Asn Gln Glu Tyr Lys Arg Ile Tyr 
        355                 360                 365             


Asn Glu His Lys Lys Leu Val Ile Lys Val Ser Thr Leu Lys Asp Gly 
    370                 375                 380                 


Gln Ala Ile Arg Arg Gly Asn Lys Lys Ile Ser Glu Leu Lys Glu Gln 
385                 390                 395                 400 


Met Lys Ser Met Thr Lys Lys Asn Ser Leu Ala Arg Leu Glu Cys Lys 
                405                 410                 415     


Met Arg Leu Ala Phe Gly Phe Leu Tyr Gly Glu Tyr Asn Asn Tyr Lys 
            420                 425                 430         


Ala Phe Lys Asn Asn Phe Asp Thr Asn Ile Lys Asn Ser Gln Phe Asp 
        435                 440                 445             


Val Asn Asp Val Glu Lys Ser Lys Ala Tyr Phe Leu Ser Thr Tyr Glu 
    450                 455                 460                 


Arg Arg Lys Pro Arg Thr Arg Glu Lys Leu Glu Lys Val Ala Lys Asp 
465                 470                 475                 480 


Ile Glu Ser Leu Glu Leu Lys Thr Val Ile Ala Asn Asp Thr Leu Leu 
                485                 490                 495     


Lys Phe Ile Leu Leu Met Phe Val Phe Met Pro Gln Glu Leu Lys Gly 
            500                 505                 510         


Asp Phe Leu Gly Phe Val Lys Lys Tyr Tyr His Asp Val His Ser Ile 
        515                 520                 525             


Asp Asp Asp Thr Lys Glu Gln Glu Glu Asp Val Val Glu Ala Met Ser 
    530                 535                 540                 


Thr Ser Leu Lys Leu Lys Ile Leu Gly Arg Asn Ile Arg Ser Leu Thr 
545                 550                 555                 560 


Leu Phe Lys Tyr Ala Leu Ser Ser Gln Val Asn Tyr Asn Ser Thr Asp 
                565                 570                 575     


Asn Ile Phe Tyr Val Glu Gly Asn Arg Tyr Gly Lys Ile Tyr Lys Lys 
            580                 585                 590         


Leu Gly Ile Ser His Asn Gln Glu Glu Phe Asp Lys Thr Leu Val Val 
        595                 600                 605             


Pro Leu Leu Arg Tyr Tyr Ser Ser Leu Phe Lys Leu Met Asn Asp Phe 
    610                 615                 620                 


Glu Ile Tyr Ser Leu Ala Lys Ala Asn Pro Thr Ala Val Ser Leu Gln 
625                 630                 635                 640 


Glu Leu Val Asp Asp Glu Thr Ser Pro Tyr Lys Gln Gly Asn Tyr Phe 
                645                 650                 655     


Asn Phe Asn Lys Met Leu Arg Asp Ile Tyr Gly Leu Thr Ser Asp Glu 
            660                 665                 670         


Ile Lys Ser Gly Gln Val Val Phe Met Arg Asn Lys Ile Ala His Phe 
        675                 680                 685             


Asp Thr Glu Val Leu Leu Ser Lys Pro Leu Leu Gly Gln Thr Lys Met 
    690                 695                 700                 


Asn Leu Gln Arg Lys Asp Ile Val Ser Phe Ile Glu Ala Arg Gly Asp 
705                 710                 715                 720 


Ile Lys Glu Leu Leu Gly Tyr Asp Ala Ile Asn Asp Phe Arg Met Lys 
                725                 730                 735     


Val Ile His Leu Arg Thr Lys Met Arg Val Tyr Ser Asp Lys Leu Gln 
            740                 745                 750         


Thr Met Met Asp Leu Leu Arg Asn Ala Lys Thr Pro Asn Asp Phe Tyr 
        755                 760                 765             


Asn Val Tyr Lys Val Lys Gly Val Glu Ser Ile Asn Lys His Leu Leu 
    770                 775                 780                 


Glu Val Leu Ala Gln Thr Ala Glu Glu Arg Thr Val Glu Lys Gln Ile 
785                 790                 795                 800 


Arg Asp Gly Asn Glu Lys Tyr Asp Leu 
                805                 


<210>  37
<211>  839
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  37

Leu Asn Ser Ile Glu Lys Ile Lys Lys Pro Ser Asn Arg Asn Ser Ile 
1               5                   10                  15      


Pro Ser Ile Ile Ile Ser Asp Tyr Asp Glu Asn Lys Ile Lys Glu Ile 
            20                  25                  30          


Lys Val Lys Tyr Leu Lys Leu Ala Arg Leu Asp Lys Ile Thr Ile Gln 
        35                  40                  45              


Asp Met Glu Ile Arg Asp Asn Ile Val Glu Phe Lys Lys Ile Leu Leu 
    50                  55                  60                  


Asn Gly Ile Glu His Thr Ile Lys Asp Asn Gln Lys Ile Glu Phe Asp 
65                  70                  75                  80  


Asn Tyr Glu Ile Thr Ala Tyr Val Arg Ala Ser Lys Gln Arg Arg Asp 
                85                  90                  95      


Gly Lys Ile Thr Gln Ala Lys Tyr Val Val Thr Ile Thr Asp Lys Tyr 
            100                 105                 110         


Leu Arg Asp Asn Glu Lys Glu Lys Arg Phe Lys Ser Thr Glu Arg Glu 
        115                 120                 125             


Leu Pro Asn Asp Thr Leu Leu Met Arg Tyr Lys Gln Ile Ser Gly Phe 
    130                 135                 140                 


Asp Thr Leu Thr Ser Lys Asp Ile Tyr Lys Ile Lys Arg Tyr Ile Asp 
145                 150                 155                 160 


Phe Lys Asn Glu Met Leu Phe Tyr Phe Gln Phe Ile Glu Glu Phe Phe 
                165                 170                 175     


Ser Pro Leu Leu Pro Lys Gly Thr Asn Phe Tyr Ser Leu Asn Ile Glu 
            180                 185                 190         


Gln Asn Lys Asp Lys Val Val Lys Tyr Ile Val Tyr Arg Leu Asn Asp 
        195                 200                 205             


Asp Phe Lys Asn Gln Ser Leu Asn Gln Phe Ile Lys Lys Thr Asp Thr 
    210                 215                 220                 


Ile Lys Tyr Asp Phe Leu Lys Ile Gln Lys Ile Leu Ser Asp Phe Arg 
225                 230                 235                 240 


His Ala Leu Ala His Phe Asp Phe Asp Phe Ile Gln Lys Phe Phe Asp 
                245                 250                 255     


Asp Glu Leu Asp Lys Asn Arg Phe Asp Ile Ser Thr Ile Ser Leu Ile 
            260                 265                 270         


Lys Thr Met Leu Gln Glu Lys Glu Glu Lys Tyr Tyr Gln Glu Lys Asn 
        275                 280                 285             


Asn Tyr Ile Glu Asp Ser Asp Thr Leu Thr Leu Phe Asp Glu Lys Glu 
    290                 295                 300                 


Ser Asn Phe Ser Lys Ile His Asn Phe Tyr Ile Lys Ile Ser Gln Lys 
305                 310                 315                 320 


Lys Pro Ala Phe Asn Lys Leu Ile Asn Ser Phe Leu Ser Lys Asp Gly 
                325                 330                 335     


Val Pro Asn Glu Glu Leu Lys Ser Tyr Leu Ala Thr Lys Lys Ile Asp 
            340                 345                 350         


Phe Phe Glu Asp Ile His Ser Asn Lys Glu Tyr Lys Lys Ile Tyr Ile 
        355                 360                 365             


Lys His Lys Asn Leu Val Val Glu Lys Gln Lys Glu Glu Ser Gln Glu 
    370                 375                 380                 


Lys Pro Asn Gly Gln Lys Leu Lys Asn Tyr Asn Asp Glu Leu Gln Lys 
385                 390                 395                 400 


Leu Lys Asp Glu Met Asn Lys Ile Thr Lys Gln Asn Ser Leu Asn Arg 
                405                 410                 415     


Leu Glu Val Lys Leu Arg Leu Ala Phe Gly Phe Ile Ala Asn Glu Tyr 
            420                 425                 430         


Asn Tyr Asn Phe Lys Asn Phe Asn Asp Lys Phe Thr Leu Asp Val Lys 
        435                 440                 445             


Lys Glu Gln Lys Ile Lys Val Phe Lys Asn Ser Ser Asn Glu Lys Leu 
    450                 455                 460                 


Lys Glu Tyr Phe Glu Ser Thr Phe Ile Glu Lys Arg Phe Phe His Phe 
465                 470                 475                 480 


Cys Val Lys Phe Phe Asn Lys Lys Thr Lys Lys Glu Glu Thr Lys Gln 
                485                 490                 495     


Lys Asn Ile Phe Asn Leu Ile Glu Asn Glu Thr Leu Glu Glu Leu Val 
            500                 505                 510         


Lys Glu Ser Pro Leu Leu Gln Ile Ile Thr Leu Leu Tyr Leu Phe Ile 
        515                 520                 525             


Pro Lys Glu Leu Gln Gly Glu Phe Val Gly Phe Ile Leu Lys Ile Tyr 
    530                 535                 540                 


His His Thr Lys Asn Ile Thr Asn Asp Thr Lys Glu Asp Glu Lys Ser 
545                 550                 555                 560 


Ile Glu Asp Thr Gln Asn Ser Phe Ser Leu Lys Leu Lys Ile Leu Ala 
                565                 570                 575     


Lys Asn Leu Arg Gly Leu Gln Leu Phe Asn Tyr Ser Leu Ser His Asn 
            580                 585                 590         


Thr Leu Tyr Asn Thr Lys Glu His Phe Phe Tyr Glu Lys Gly Asn Arg 
        595                 600                 605             


Trp Gln Ser Val Tyr Lys Ser Leu Glu Ile Ser His Asn Gln Asp Glu 
    610                 615                 620                 


Phe Asp Ile His Leu Val Ile Pro Val Ile Lys Tyr Tyr Ile Asn Leu 
625                 630                 635                 640 


Asn Lys Leu Ile Gly Asp Phe Glu Ile Tyr Ala Leu Leu Thr Tyr Ala 
                645                 650                 655     


Asp Lys Asn Ser Ile Thr Glu Lys Leu Ser Asp Ile Thr Lys Arg Asp 
            660                 665                 670         


Asp Leu Lys Phe Arg Gly Tyr Tyr Asn Phe Ser Thr Leu Leu Phe Lys 
        675                 680                 685             


Thr Phe Met Ile Asn Thr Asn Tyr Glu Gln Asn Gln Lys Ser Thr Gln 
    690                 695                 700                 


Tyr Ile Lys Gln Thr Arg Asn Asp Ile Ala His Gln Asn Ile Glu Asn 
705                 710                 715                 720 


Met Leu Lys Ala Phe Glu Asn Asn Glu Ile Phe Ala Gln Arg Glu Glu 
                725                 730                 735     


Ile Val Asn Tyr Leu Gln Lys Glu His Lys Met Gln Glu Ile Leu His 
            740                 745                 750         


Tyr Asn Pro Ile Asn Asp Phe Thr Met Lys Thr Val Gln Tyr Leu Lys 
        755                 760                 765             


Ser Leu Asn Ile His Ser Gln Lys Glu Ser Lys Ile Ala Asp Ile His 
    770                 775                 780                 


Lys Lys Glu Ser Leu Val Pro Asn Asp Tyr Tyr Leu Ile Tyr Lys Leu 
785                 790                 795                 800 


Lys Val Ile Glu Leu Leu Lys Gln Lys Val Ile Glu Ala Ile Gly Glu 
                805                 810                 815     


Thr Lys Asp Glu Glu Lys Ile Lys Asn Ala Ile Ala Lys Glu Glu Gln 
            820                 825                 830         


Ile Lys Lys Gly Tyr Asn Lys 
        835                 


<210>  38
<211>  840
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  38

Met Leu Lys His Lys Arg Lys Asn Lys Asn Ser Leu Ala Arg Val Val 
1               5                   10                  15      


Leu Ser Asn Tyr Asp Ser Asn Asn Ile Tyr Glu Ile Lys Ile Lys Tyr 
            20                  25                  30          


Glu Lys Leu Ala Lys Leu Asp Lys Ile Asn Ile Ile Glu Met Asp Tyr 
        35                  40                  45              


Asp Ala Asp Asn Asn Val Met Phe Lys Lys Val Leu Phe Asn Asn Lys 
    50                  55                  60                  


Glu Ile Asp Leu Ser His Lys Asp Lys Thr Lys Ile Asn Ile Glu Leu 
65                  70                  75                  80  


Asp Asn Lys Lys Tyr Asn Ile Ser Ala Lys Lys Gln Ile Gly Lys Thr 
                85                  90                  95      


His Leu Val Val Arg Asn Lys Gln Thr Ser Lys Ile Ser Arg Ile Lys 
            100                 105                 110         


Lys Ile Gln Asp Thr Tyr Tyr Arg Gly Lys Asp Val Phe Ile Leu Asp 
        115                 120                 125             


Asn Asn Ile Glu Ile Leu Asp Lys Lys Gln Thr Lys Asp Lys Phe Ile 
    130                 135                 140                 


Val Thr Leu Asn Asp Ile Thr Asn Asn Lys Thr Thr Ser Thr Glu Ala 
145                 150                 155                 160 


Glu Leu Ile Asp Asp Thr Lys Asp Ile Phe Lys Lys Ile Ser Ala Lys 
                165                 170                 175     


Lys Asp Leu Lys Ser Ser Asp Ile Tyr Lys Ile Lys Arg Phe Ile Ser 
            180                 185                 190         


Ile Arg Ser Asn Phe Ser Phe Tyr Tyr Thr Phe Val Asp Asn Tyr Phe 
        195                 200                 205             


Lys Ile Phe His Ala Lys Lys Asp Lys Asn Lys Glu Glu Leu Tyr Lys 
    210                 215                 220                 


Ile Lys Phe Lys Asp Glu Ile Asn Ile Lys Pro Tyr Leu Glu Asn Ile 
225                 230                 235                 240 


Leu Asp Asn Met Lys Asn Lys Asn Gly Ile Leu Tyr Asn Tyr Ala Asn 
                245                 250                 255     


Asp Arg Lys Lys Val Leu Asn Asp Leu Arg Asn Ile Gln Tyr Val Phe 
            260                 265                 270         


Lys Glu Phe Arg His Lys Leu Ala His Phe Asp Tyr Asn Phe Leu Asp 
        275                 280                 285             


Asn Phe Phe Ser Asn Ser Val Glu Glu Lys Tyr Lys Gln Lys Val Asn 
    290                 295                 300                 


Glu Ile Lys Leu Leu Asp Ile Leu Leu Asp Asn Ile Asp Ser Leu Asn 
305                 310                 315                 320 


Val Val Pro Lys Gln Asn Tyr Ile Glu Asp Glu Thr Ile Ser Val Phe 
                325                 330                 335     


Asp Ala Lys Asp Ile Lys Leu Lys Arg Leu Tyr Thr Tyr Tyr Ile Lys 
            340                 345                 350         


Leu Thr Ile Asn Tyr Pro Gly Phe Lys Lys Leu Ile Asn Ser Phe Phe 
        355                 360                 365             


Ile Gln Asp Gly Ile Glu Asn Gln Glu Leu Lys Glu Tyr Ile Asn Asn 
    370                 375                 380                 


Lys Glu Lys Asp Thr Gln Val Leu Lys Glu Leu Asp Asn Lys Ala Tyr 
385                 390                 395                 400 


Tyr Met Asp Ile Ser Gln Tyr Arg Lys Tyr Lys Asn Ile Tyr Asn Lys 
                405                 410                 415     


His Lys Glu Leu Val Ser Glu Lys Glu Leu Ser Ser Asp Gly Lys Lys 
            420                 425                 430         


Ile Asn Ser Leu Asn Gln Lys Ile Asn Lys Leu Lys Ile Asp Met Lys 
        435                 440                 445             


Asn Ile Thr Lys Pro Asn Ala Leu Asn Arg Leu Ile Tyr Arg Leu Arg 
    450                 455                 460                 


Val Ala Phe Gly Phe Ile Tyr Lys Glu Tyr Ala Thr Ile Asn Asn Phe 
465                 470                 475                 480 


Asn Lys Ser Phe Leu Gln Asp Thr Lys Thr Lys Arg Phe Glu Asn Ile 
                485                 490                 495     


Ser Gln Gln Asp Ile Lys Ser Tyr Leu Asp Ile Ser Tyr Gln Asp Lys 
            500                 505                 510         


Gly Lys Phe Phe Val Lys Ser Lys Lys Thr Phe Lys Asn Lys Thr Thr 
        515                 520                 525             


Val Lys Tyr Thr Phe Glu Asp Leu Asp Leu Thr Leu Asn Glu Ile Ile 
    530                 535                 540                 


Thr Gln Asp Asp Ile Phe Val Lys Val Ile Phe Leu Phe Ser Ile Phe 
545                 550                 555                 560 


Met Pro Lys Glu Leu Asn Gly Asp Phe Phe Gly Phe Ile Asn Met Tyr 
                565                 570                 575     


Tyr His Lys Met Lys Asn Ile Ser Tyr Asp Thr Lys Asp Ile Asp Met 
            580                 585                 590         


Leu Asp Thr Ile Ser Gln Asn Met Lys Leu Lys Ile Leu Glu Gln Asn 
        595                 600                 605             


Ile Lys Lys Thr Tyr Val Phe Lys Tyr Tyr Leu Asp Leu Asp Ser Ser 
    610                 615                 620                 


Ile Tyr Ser Lys Leu Val Gln Asn Ile Lys Ile Thr Glu Asp Ile Asp 
625                 630                 635                 640 


Ser Lys Lys Tyr Leu Tyr Ala Lys Ile Phe Lys Tyr Tyr Gln His Leu 
                645                 650                 655     


Tyr Lys Leu Ile Ser Asp Val Glu Ile Tyr Leu Leu Tyr Lys Tyr Asn 
            660                 665                 670         


Ser Lys Glu Asn Leu Ser Ile Thr Ile Asp Lys Asp Glu Leu Lys His 
        675                 680                 685             


Arg Gly Tyr Tyr Asn Phe Gln Ser Leu Leu Ile Lys Asn Asn Ile Asn 
    690                 695                 700                 


Lys Asp Asp Ala Tyr Trp Ser Ile Val Asn Met Arg Asn Asn Leu Ser 
705                 710                 715                 720 


His Gln Asn Ile Asp Glu Leu Val Gly His Phe Cys Lys Gly Cys Leu 
                725                 730                 735     


Arg Lys Ser Thr Thr Asp Ile Ala Glu Leu Trp Leu Arg Lys Asp Ile 
            740                 745                 750         


Leu Thr Ile Thr Asn Glu Ile Ile Asn Lys Ile Glu Ser Phe Lys Asp 
        755                 760                 765             


Ile Lys Ile Thr Leu Gly Tyr Asp Cys Val Asn Asp Phe Thr Gln Lys 
    770                 775                 780                 


Val Lys Gln Tyr Lys Gln Lys Leu Lys Ala Ser Asn Glu Arg Leu Ala 
785                 790                 795                 800 


Lys Lys Ile Glu Glu Lys Gln Asn Gln Val Val Asp Glu Lys Asn Lys 
                805                 810                 815     


Glu Glu Leu Glu Lys Asn Ile Leu Asn Met Lys Asn Ile Gln Lys Ile 
            820                 825                 830         


Asn Arg Tyr Ile Leu Asp Ile Leu 
        835                 840 


<210>  39
<211>  840
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  39

Met Leu Lys His Lys Arg Lys Asn Lys Asn Ser Leu Ala Arg Val Val 
1               5                   10                  15      


Leu Ser Asn Tyr Asp Ser Asn Asn Ile Tyr Glu Ile Lys Ile Lys Tyr 
            20                  25                  30          


Glu Lys Leu Ala Lys Leu Asp Lys Ile Asn Ile Ile Glu Met Asp Tyr 
        35                  40                  45              


Asp Ala Asp Asn Asn Val Met Phe Lys Lys Val Leu Phe Asn Asn Lys 
    50                  55                  60                  


Glu Ile Asp Leu Ser His Lys Asp Lys Thr Lys Ile Asn Ile Glu Leu 
65                  70                  75                  80  


Asp Asn Lys Lys Tyr Asn Ile Ser Ala Lys Lys Gln Ile Gly Lys Thr 
                85                  90                  95      


His Leu Val Val Arg Asp Lys Gln Thr Ser Lys Ile Ser Arg Ile Lys 
            100                 105                 110         


Lys Ile Gln Asp Thr Tyr Tyr Arg Gly Lys Asp Val Phe Ile Leu Asp 
        115                 120                 125             


Asn Asn Ile Glu Ile Leu Asp Lys Lys Gln Thr Lys Asp Lys Phe Ile 
    130                 135                 140                 


Val Thr Leu Asn Asp Ile Thr Asn Asp Lys Thr Thr Ser Thr Glu Ala 
145                 150                 155                 160 


Glu Leu Ile Asp Asp Thr Lys Asp Ile Phe Lys Lys Ile Ser Ala Lys 
                165                 170                 175     


Lys Asp Leu Lys Ser Ser Asp Ile Tyr Lys Ile Lys Arg Phe Ile Ser 
            180                 185                 190         


Ile Arg Ser Asn Phe Ser Phe Tyr Tyr Thr Phe Val Asp Asn Tyr Phe 
        195                 200                 205             


Lys Ile Phe His Ala Lys Lys Asp Lys Asn Lys Glu Glu Leu Tyr Lys 
    210                 215                 220                 


Ile Lys Phe Lys Asp Glu Ile Asn Ile Lys Pro Tyr Leu Glu Asn Ile 
225                 230                 235                 240 


Leu Asp Asn Met Lys Asn Lys Asn Gly Ile Leu Tyr Asp Tyr Ala Asp 
                245                 250                 255     


Asp Arg Glu Lys Val Leu Asn Asp Leu Lys Asn Ile Gln Tyr Val Phe 
            260                 265                 270         


Thr Glu Phe Arg His Lys Leu Ala His Phe Asp Tyr Asn Phe Leu Asp 
        275                 280                 285             


Asn Phe Phe Ser Asn Ser Val Thr Asp Gln Tyr Lys Gln Lys Val Asn 
    290                 295                 300                 


Glu Ile Lys Leu Leu Asp Ile Leu Leu Asp Asn Ile Asp Ser Leu Asn 
305                 310                 315                 320 


Val Val Pro Lys Gln Asn Tyr Ile Glu Asp Glu Thr Ile Ser Val Phe 
                325                 330                 335     


Asp Ala Lys Asp Ile Lys Leu Lys Arg Leu Tyr Thr Tyr Tyr Ile Lys 
            340                 345                 350         


Leu Thr Ile Asn Tyr Pro Gly Phe Lys Lys Leu Ile Asn Ser Phe Phe 
        355                 360                 365             


Ile Gln Asp Gly Ile Glu Asn Gln Glu Leu Lys Glu Tyr Ile Asn Asn 
    370                 375                 380                 


Lys Glu Lys Asp Thr Gln Val Leu Lys Glu Leu Asp Asn Lys Ala Tyr 
385                 390                 395                 400 


Tyr Met Asp Ile Ser Gln Tyr Arg Lys Tyr Lys Asn Ile Tyr Asn Lys 
                405                 410                 415     


His Lys Glu Leu Val Ser Glu Lys Glu Leu Ser Ser Asp Gly Gln Lys 
            420                 425                 430         


Ile Asn Ser Leu Asn Gln Lys Ile Asn Lys Leu Lys Ile Glu Met Lys 
        435                 440                 445             


Asn Ile Thr Lys Pro Asn Ala Leu Asn Arg Leu Ile Tyr Arg Leu Arg 
    450                 455                 460                 


Val Ala Phe Gly Phe Ile Tyr Lys Glu Tyr Ala Thr Ile Asn Asn Phe 
465                 470                 475                 480 


Asn Lys Ser Phe Leu Gln Asp Thr Lys Ile Lys Arg Phe Glu Asn Ile 
                485                 490                 495     


Ser Gln Gln Asp Ile Lys Asn Tyr Leu Asp Ile Ser Tyr Gln Asp Lys 
            500                 505                 510         


Gly Lys Phe Phe Val Lys Ser Lys Lys Thr Phe Lys Asn Lys Thr Thr 
        515                 520                 525             


Ile Lys Tyr Thr Phe Glu Asp Leu Asp Leu Thr Leu Asn Glu Ile Ile 
    530                 535                 540                 


Thr Gln Asp Asp Ile Phe Val Lys Val Ile Phe Leu Phe Ser Ile Phe 
545                 550                 555                 560 


Met Pro Lys Glu Leu Asn Gly Asp Phe Phe Gly Phe Ile Asn Met Tyr 
                565                 570                 575     


Tyr His Lys Met Lys Asn Ile Ser Tyr Asp Thr Lys Asp Ile Asp Met 
            580                 585                 590         


Leu Asp Thr Ile Ser Gln Asn Met Lys Leu Lys Ile Leu Glu Gln Asn 
        595                 600                 605             


Ile Lys Lys Thr Tyr Val Phe Lys Tyr Tyr Leu Asp Leu Asp Ser Ser 
    610                 615                 620                 


Ile Tyr Ser Lys Leu Val Gln Asn Ile Lys Ile Thr Glu Asp Ile Asp 
625                 630                 635                 640 


Ser Lys Lys Tyr Leu Tyr Ala Lys Ile Phe Lys Tyr Tyr Gln His Leu 
                645                 650                 655     


Tyr Lys Leu Ile Ser Asp Val Glu Ile Tyr Leu Leu Tyr Lys Tyr Asn 
            660                 665                 670         


Ser Lys Glu Asn Leu Ser Ile Thr Ile Asp Lys Asp Glu Leu Lys His 
        675                 680                 685             


Arg Gly Tyr Tyr Asn Phe Gln Ser Leu Leu Ile Lys Asn Asn Ile Asn 
    690                 695                 700                 


Lys Asp Asp Ala Tyr Trp Ser Ile Val Asn Met Arg Asn Asn Leu Ser 
705                 710                 715                 720 


His Gln Asn Ile Asp Glu Leu Val Gly His Phe Cys Lys Gly Cys Leu 
                725                 730                 735     


Arg Lys Ser Thr Thr Asp Ile Ala Glu Leu Trp Leu Arg Lys Asp Ile 
            740                 745                 750         


Leu Thr Ile Thr Asn Glu Ile Ile Asn Lys Ile Glu Ser Phe Lys Asp 
        755                 760                 765             


Ile Lys Ile Thr Leu Gly Tyr Asp Cys Val Asn Asp Phe Thr Gln Lys 
    770                 775                 780                 


Val Lys Gln Tyr Lys Gln Lys Leu Lys Ala Ser Asn Glu Arg Leu Ala 
785                 790                 795                 800 


Lys Lys Ile Glu Glu Lys Gln Asn Gln Val Val Asp Glu Lys Asn Lys 
                805                 810                 815     


Glu Glu Leu Glu Lys Lys Ile Leu Asn Met Lys Asn Ile Gln Lys Ile 
            820                 825                 830         


Asn Arg Tyr Ile Leu Asp Ile Leu 
        835                 840 


<210>  40
<211>  849
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  40

Met Ser Gln Leu Lys Asn Pro Ser Asn Lys Asn Ser Leu Pro Arg Ile 
1               5                   10                  15      


Ile Ile Ser Asp Phe Asn Glu Ile Lys Ile Asn Glu Ile Lys Ile Lys 
            20                  25                  30          


Tyr His Lys Leu Asp Arg Leu Asp Lys Ile Ile Val Lys Glu Met Glu 
        35                  40                  45              


Ile Ile Asn Asn Lys Ile Phe Phe Lys Lys Ile Leu Phe Asn Asn Gln 
    50                  55                  60                  


Ile Lys Asp Ile Asn Ser Glu Asn Ile Glu Leu Glu Asn Tyr Ile Leu 
65                  70                  75                  80  


Ala Gly Glu Val Lys Pro Ser Asn Thr Lys Ile Ile Leu Asn Arg Asp 
                85                  90                  95      


Gly Lys Glu Lys Ser Phe Ile Val Tyr Asp Gly Phe Thr Phe Lys Tyr 
            100                 105                 110         


Lys Pro Asn Asp Lys Arg Ile Ser Glu Thr Lys Thr Asn Ala Lys Tyr 
        115                 120                 125             


Ile Leu Thr Ile Lys Asp Lys Thr Arg His Arg Glu Ser Ser Thr Gln 
    130                 135                 140                 


Arg Asp Ile Leu Lys Ser Ser Ile Ile Glu Thr Tyr Lys Gln Ile Ser 
145                 150                 155                 160 


Gly Phe Glu Asn Ile Thr Ser Lys Asp Ile Tyr Thr Ile Lys Arg Tyr 
                165                 170                 175     


Ile Asp Phe Lys Asn Glu Met Met Phe Tyr Tyr Thr Phe Ile Asp Asp 
            180                 185                 190         


Phe Phe Phe Pro Ile Thr Gly Lys Asn Lys Gln Asp Lys Lys Asn Asn 
        195                 200                 205             


Phe Tyr Asn Tyr Lys Ile Lys Glu Asn Ala Lys Lys Phe Ile Ser Leu 
    210                 215                 220                 


Ile Asn Tyr Arg Ile Asn Asp Asp Phe Lys Asn Lys Asn Gly Ile Leu 
225                 230                 235                 240 


Tyr Asp Tyr Leu Ser Asn Lys Glu Glu Ile Ile Ile Asn Asp Phe Ile 
                245                 250                 255     


His Ile Gln Thr Ile Leu Lys Asp Val Arg His Ala Ile Ala His Phe 
            260                 265                 270         


Asn Phe Asp Phe Ile Gln Lys Leu Phe Asp Asn Glu Gln Ala Phe Asn 
        275                 280                 285             


Ser Lys Phe Asp Gly Ile Glu Ile Leu Asn Ile Leu Phe Asn Gln Lys 
    290                 295                 300                 


Gln Glu Lys Tyr Phe Glu Ala Gln Thr Asn Tyr Ile Glu Glu Glu Thr 
305                 310                 315                 320 


Ile Lys Ile Leu Asp Glu Lys Glu Leu Ser Phe Lys Lys Leu His Ser 
                325                 330                 335     


Phe Tyr Ser Gln Ile Cys Gln Lys Lys Pro Ala Phe Asn Lys Leu Ile 
            340                 345                 350         


Asn Ser Phe Ile Ile Gln Asp Gly Ile Glu Asn Lys Glu Leu Lys Asp 
        355                 360                 365             


Tyr Ile Ser Gln Lys Tyr Asn Ser Lys Phe Asp Tyr Tyr Leu Asp Ile 
    370                 375                 380                 


His Thr Cys Lys Ile Tyr Lys Asp Ile Tyr Asn Gln His Lys Lys Phe 
385                 390                 395                 400 


Val Ala Asp Lys Gln Phe Leu Glu Asn Gln Lys Thr Asp Gly Gln Lys 
                405                 410                 415     


Ile Lys Lys Leu Asn Asp Gln Ile Asn Gln Leu Lys Thr Lys Met Asn 
            420                 425                 430         


Asn Leu Thr Lys Lys Asn Ser Leu Lys Arg Leu Glu Ile Lys Phe Arg 
        435                 440                 445             


Leu Ala Phe Gly Phe Ile Phe Thr Glu Tyr Gln Thr Phe Lys Asn Phe 
    450                 455                 460                 


Asn Glu Arg Phe Ile Glu Asp Ile Lys Ala Asn Lys Tyr Ser Thr Lys 
465                 470                 475                 480 


Ile Glu Leu Leu Asp Tyr Gly Lys Ile Lys Glu Tyr Ile Ser Ile Thr 
                485                 490                 495     


His Glu Glu Lys Arg Phe Phe Asn Tyr Lys Thr Phe Asn Lys Lys Thr 
            500                 505                 510         


Asn Lys Asn Ile Asn Lys Thr Ile Phe Gln Ser Leu Glu Lys Glu Thr 
        515                 520                 525             


Phe Glu Asn Leu Val Lys Asn Asp Asn Leu Ile Lys Met Met Phe Leu 
    530                 535                 540                 


Phe Gln Leu Leu Leu Pro Arg Glu Leu Lys Gly Glu Phe Leu Gly Phe 
545                 550                 555                 560 


Ile Leu Lys Ile Tyr His Asp Leu Lys Asn Ile Asp Asn Asp Thr Lys 
                565                 570                 575     


Pro Asp Glu Lys Ser Leu Ser Glu Leu Asn Ile Ser Thr Ala Leu Lys 
            580                 585                 590         


Leu Lys Ile Leu Val Lys Asn Ile Arg Gln Ile Asn Leu Phe Asn Tyr 
        595                 600                 605             


Thr Ile Ser Asn Asn Thr Lys Tyr Glu Glu Lys Glu Lys Arg Phe Tyr 
    610                 615                 620                 


Glu Glu Gly Asn Gln Trp Lys Asp Ile Tyr Lys Lys Leu Tyr Ile Ser 
625                 630                 635                 640 


His Asp Phe Asp Ile Phe Asp Ile His Leu Ile Ile Pro Ile Ile Lys 
                645                 650                 655     


Tyr Asn Ile Asn Leu Tyr Lys Leu Ile Gly Asp Phe Glu Val Tyr Leu 
            660                 665                 670         


Leu Leu Lys Tyr Leu Glu Arg Asn Thr Asn Tyr Lys Thr Leu Asp Lys 
        675                 680                 685             


Leu Ile Glu Ala Glu Glu Leu Lys Tyr Lys Gly Tyr Tyr Asn Phe Thr 
    690                 695                 700                 


Thr Leu Leu Ser Lys Ala Ile Asn Ile Ala Leu Asn Asp Lys Glu Tyr 
705                 710                 715                 720 


His Asn Ile Thr His Leu Arg Asn Asn Thr Ser His Gln Asp Ile Gln 
                725                 730                 735     


Asn Ile Ile Ser Ser Phe Lys Asn Asn Lys Leu Leu Glu Gln Arg Glu 
            740                 745                 750         


Asn Ile Ile Glu Leu Ile Ser Lys Glu Ser Leu Lys Lys Lys Leu His 
        755                 760                 765             


Phe Asp Pro Ile Asn Asp Phe Thr Met Lys Thr Leu Gln Leu Leu Lys 
    770                 775                 780                 


Ser Leu Glu Val His Ser Asp Lys Ser Glu Lys Ile Glu Asn Leu Leu 
785                 790                 795                 800 


Lys Lys Glu Pro Leu Leu Pro Asn Asp Val Tyr Leu Leu Tyr Lys Leu 
                805                 810                 815     


Lys Gly Ile Glu Phe Ile Lys Lys Glu Leu Ile Ser Asn Ile Gly Ile 
            820                 825                 830         


Thr Lys Tyr Glu Glu Lys Ile Gln Glu Lys Ile Ala Lys Gly Val Glu 
        835                 840                 845             


Lys 
    


<210>  41
<211>  822
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  41

Met Val Lys Asn Pro Ala Asn Arg His Ala Leu Pro Lys Val Ile Ile 
1               5                   10                  15      


Ser Glu Val Asp Asn Asn Asn Ile Leu Glu Phe Lys Ile Lys Tyr Glu 
            20                  25                  30          


Lys Leu Ala Arg Leu Asp Lys Val Glu Val Lys Ser Met His Phe Asp 
        35                  40                  45              


Asn Asn Lys Gln Val Val Phe Asp Glu Val Val Ile Asn Gly Gly Leu 
    50                  55                  60                  


Ile Glu Pro Thr Tyr Glu Asp Lys His Lys Lys Leu Val Val Thr Ala 
65                  70                  75                  80  


Gly Glu Lys Ser Tyr Ser Ile Val Gly Gln Lys Val Gly Gly Lys Pro 
                85                  90                  95      


Arg Leu Leu Glu Asp Arg Val Ser Lys Thr Lys Val Gln Leu Glu Leu 
            100                 105                 110         


Thr Asn Tyr Val Glu Asp Lys Glu Gly Lys Lys Arg Val Ser Lys Thr 
        115                 120                 125             


Glu Arg Glu Leu Ile Val Ala Asp Asn Ile Glu Leu Tyr Ser Gln Ile 
    130                 135                 140                 


Val Gly Arg Glu Val Lys Thr Thr Lys Glu Ile Tyr Leu Ile Lys Arg 
145                 150                 155                 160 


Phe Leu Glu Tyr Arg Ser Asp Leu Leu Phe Tyr Tyr Gly Phe Val Asp 
                165                 170                 175     


Asn Phe Phe Lys Val Ala Gly Asn Gly Lys Glu Leu Trp Lys Ile Asp 
            180                 185                 190         


Phe Thr Asn Ser Asp Ser Leu His Leu Ile Glu Tyr Phe Lys Phe Ser 
        195                 200                 205             


Ile Asn Asp Asn Leu Lys Asn Asp Glu Asn Tyr Leu Lys Asn Tyr Val 
    210                 215                 220                 


Ser Asp Asn Thr Lys Ile Glu Asn Asp Leu Val Lys Cys Gln Asn Asn 
225                 230                 235                 240 


Phe Asn Ser Leu Arg His Ala Leu Met His Phe Asp Tyr Asp Phe Phe 
                245                 250                 255     


Glu Lys Leu Phe Asn Gly Glu Asp Val Gly Phe Asp Phe Asp Ile Glu 
            260                 265                 270         


Phe Leu Asn Ile Met Ile Asp Lys Val Asp Lys Leu Asn Ile Asp Thr 
        275                 280                 285             


Lys Lys Glu Phe Ile Asp Asp Glu Glu Val Thr Leu Phe Gly Glu Ala 
    290                 295                 300                 


Leu Ser Leu Lys Lys Leu Tyr Gly Leu Phe Ser His Ile Ala Ile Asn 
305                 310                 315                 320 


Arg Val Ala Phe Asn Lys Leu Ile Asn Ser Phe Ile Ile Glu Asp Gly 
                325                 330                 335     


Ile Glu Asn Lys Glu Leu Lys Asp Phe Phe Asn Asn Lys Lys Glu Ser 
            340                 345                 350         


Gln Ala Tyr Glu Ile Asp Ile His Ser Asn Ala Glu Tyr Lys Ala Leu 
        355                 360                 365             


Tyr Val Gln His Lys Lys Leu Val Met Ala Thr Ser Ala Met Thr Asp 
    370                 375                 380                 


Gly Asp Glu Ile Ala Lys Lys Asn Gln Glu Ile Ser Asp Leu Lys Glu 
385                 390                 395                 400 


Lys Met Lys Val Ile Thr Lys Glu Asn Ser Leu Ala Arg Leu Glu His 
                405                 410                 415     


Lys Leu Arg Leu Ala Phe Gly Phe Ile Tyr Thr Glu Tyr Lys Asp Tyr 
            420                 425                 430         


Lys Thr Phe Lys Lys His Phe Asp Gln Asp Ile Lys Gly Ala Lys Tyr 
        435                 440                 445             


Lys Gly Leu Asn Val Glu Lys Leu Lys Glu Tyr Tyr Glu Thr Thr Leu 
    450                 455                 460                 


Lys Asn Ser Lys Pro Lys Thr Asp Glu Lys Leu Glu Asp Val Ala Lys 
465                 470                 475                 480 


Lys Ile Asp Lys Leu Ser Leu Lys Glu Leu Ile Asp Asp Asp Thr Leu 
                485                 490                 495     


Leu Lys Phe Val Leu Leu Leu Phe Ile Phe Met Pro Gln Glu Leu Lys 
            500                 505                 510         


Gly Asp Phe Leu Gly Phe Ile Lys Lys Tyr Tyr His Asp Lys Lys His 
        515                 520                 525             


Ile Asp Gln Asp Thr Lys Asp Lys Asp Thr Glu Ile Glu Glu Leu Ser 
    530                 535                 540                 


Thr Gly Leu Lys Leu Lys Val Leu Asp Lys Asn Ile Arg Ser Leu Ser 
545                 550                 555                 560 


Ile Leu Lys His Ser Phe Ser Phe Gln Val Lys Tyr Asn Arg Lys Asp 
                565                 570                 575     


Lys Asn Phe Tyr Glu Asp Gly Asn Leu His Gly Lys Phe Tyr Lys Lys 
            580                 585                 590         


Leu Ser Ile Ser His Asn Gln Glu Glu Phe Asn Lys Ser Val Tyr Ala 
        595                 600                 605             


Pro Leu Phe Arg Tyr Tyr Ser Ala Leu Tyr Lys Leu Ile Asn Asp Phe 
    610                 615                 620                 


Glu Ile Tyr Ala Leu Ala Gln His Val Glu Asn His Glu Thr Leu Ala 
625                 630                 635                 640 


Asp Gln Val Asn Lys Ser Gln Phe Ile Gln Lys Ser Tyr Phe Asn Phe 
                645                 650                 655     


Arg Lys Leu Leu Asp Asn Thr Asp Ser Ile Ser Gln Ser Ser Ser Tyr 
            660                 665                 670         


Asn Thr Leu Ile Val Met Arg Asn Asp Ile Ser His Leu Ser Tyr Glu 
        675                 680                 685             


Pro Leu Phe Asn Tyr Pro Leu Asp Glu Arg Lys Ser Tyr Lys Lys Lys 
    690                 695                 700                 


Thr Gln Lys Gly Val Lys Thr Phe His Val Glu Leu Leu Tyr Ile Ser 
705                 710                 715                 720 


Arg Ala Lys Ile Ile Glu Leu Ile Ser Leu Gln Thr Asp Met Lys Lys 
                725                 730                 735     


Leu Leu Gly Tyr Asp Ala Val Asn Asp Phe Asn Met Lys Val Val His 
            740                 745                 750         


Leu Arg Lys Arg Leu Ser Val Tyr Ala Asn Lys Glu Glu Ser Ile Arg 
        755                 760                 765             


Lys Met Gln Ala Asp Ala Lys Thr Pro Asn Asp Phe Tyr Asn Ile Tyr 
    770                 775                 780                 


Lys Val Lys Gly Val Glu Ser Ile Asn Gln His Leu Leu Lys Val Ile 
785                 790                 795                 800 


Gly Val Thr Glu Ala Glu Lys Ser Ile Glu Lys Gln Ile Asn Glu Gly 
                805                 810                 815     


Asn Lys Lys His Asn Thr 
            820         


<210>  42
<211>  806
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  42

Met Thr Lys Lys Pro Ser Asn Arg Asn Ser Leu Pro Lys Val Ile Ile 
1               5                   10                  15      


Asn Lys Val Asp Glu Ser Ser Ile Leu Glu Phe Lys Ile Lys Tyr Glu 
            20                  25                  30          


Lys Leu Ala Arg Leu Asp Arg Phe Glu Val Arg Ser Met Arg Tyr Asp 
        35                  40                  45              


Gly Asp Gly Arg Ile Ile Phe Asp Glu Val Val Ala Asn Ala Gly Leu 
    50                  55                  60                  


Leu Asp Val Asp Tyr Glu Asp Asp Asn Arg Thr Ile Val Val Lys Ile 
65                  70                  75                  80  


Glu Asn Lys Ala Tyr Asn Ile Tyr Gly Lys Lys Val Gly Gly Glu Lys 
                85                  90                  95      


Arg Leu Asn Gly Lys Ile Ser Lys Ala Lys Val Gln Leu Ile Leu Thr 
            100                 105                 110         


Asp Ser Ile Arg Lys Asn Ala Asn Asp Thr His Arg His Ser Leu Thr 
        115                 120                 125             


Glu Arg Glu Leu Ile Asn Lys Asn Glu Val Asp Leu Tyr Ser Lys Ile 
    130                 135                 140                 


Ala Glu Arg Glu Ile Ser Thr Thr Lys Asp Ile Tyr Leu Val Lys Arg 
145                 150                 155                 160 


Phe Leu Ala Tyr Arg Ser Asp Leu Leu Leu Tyr Tyr Ala Phe Ile Asn 
                165                 170                 175     


His Tyr Val Arg Val Asn Gly Asn Lys Lys Glu Phe Trp Lys Thr Glu 
            180                 185                 190         


Ile Asp Asp Lys Ile Ile Asp Tyr Phe Ile Tyr Thr Ile Asn Asp Thr 
        195                 200                 205             


Leu Lys Asn Lys Glu Gly Tyr Leu Glu Lys Tyr Ile Val Asp Arg Asp 
    210                 215                 220                 


Gln Ile Lys Lys Asp Leu Glu Lys Ile Lys Gln Ile Phe Ser His Leu 
225                 230                 235                 240 


Arg His Lys Leu Met His Tyr Asp Phe Arg Phe Phe Thr Asp Leu Phe 
                245                 250                 255     


Asp Gly Lys Asp Val Asp Ile Lys Val Asp Asn Ser Ile Gln Lys Ile 
            260                 265                 270         


Ser Glu Leu Leu Asp Ile Glu Phe Leu Asn Ile Val Ile Asp Lys Leu 
        275                 280                 285             


Glu Lys Leu Asn Ile Asp Ala Lys Lys Glu Phe Ile Asp Asp Glu Lys 
    290                 295                 300                 


Ile Thr Leu Phe Gly Gln Glu Ile Glu Leu Lys Lys Leu Tyr Ser Leu 
305                 310                 315                 320 


Tyr Ala His Thr Ser Ile Asn Arg Val Ala Phe Asn Lys Leu Ile Asn 
                325                 330                 335     


Ser Phe Leu Ile Lys Asp Gly Val Glu Asn Lys Glu Leu Lys Glu Tyr 
            340                 345                 350         


Phe Asn Ala His Asn Gln Gly Lys Glu Ser Tyr Tyr Ile Asp Ile His 
        355                 360                 365             


Gln Asn Gln Glu Tyr Lys Lys Leu Tyr Ile Glu His Lys Asn Leu Val 
    370                 375                 380                 


Ala Lys Leu Ser Ala Thr Thr Asp Gly Lys Glu Ile Ala Lys Ile Asn 
385                 390                 395                 400 


Arg Glu Leu Ala Asp Lys Lys Glu Gln Met Lys Gln Ile Thr Lys Ala 
                405                 410                 415     


Asn Ser Leu Lys Arg Leu Glu Tyr Lys Leu Arg Leu Ala Phe Gly Phe 
            420                 425                 430         


Ile Tyr Thr Glu Tyr Lys Asp Tyr Glu Arg Phe Lys Asn Ser Phe Asp 
        435                 440                 445             


Thr Asp Thr Lys Lys Lys Lys Phe Asp Ala Ile Asp Asn Ala Lys Ile 
    450                 455                 460                 


Ile Glu Tyr Phe Glu Ala Thr Asn Lys Ala Lys Lys Ile Glu Lys Leu 
465                 470                 475                 480 


Glu Glu Ile Leu Lys Gly Ile Asp Lys Leu Ser Leu Lys Thr Leu Ile 
                485                 490                 495     


Gln Asp Asp Ile Leu Leu Lys Phe Leu Leu Leu Phe Phe Thr Phe Leu 
            500                 505                 510         


Pro Gln Glu Ile Lys Gly Glu Phe Leu Gly Phe Ile Lys Lys Tyr Tyr 
        515                 520                 525             


His Asp Ile Thr Ser Leu Asp Glu Asp Thr Lys Asp Lys Asp Asp Glu 
    530                 535                 540                 


Ile Thr Glu Leu Pro Arg Ser Leu Lys Leu Lys Ile Phe Ser Lys Asn 
545                 550                 555                 560 


Ile Arg Lys Leu Ser Ile Leu Lys His Ser Leu Ser Tyr Gln Ile Lys 
                565                 570                 575     


Tyr Asn Lys Lys Glu Ser Ser Tyr Tyr Glu Ala Gly Asn Val Phe Asn 
            580                 585                 590         


Lys Met Phe Lys Lys Gln Ala Ile Ser His Asn Leu Glu Glu Phe Gly 
        595                 600                 605             


Lys Ser Ile Tyr Leu Pro Met Leu Lys Tyr Tyr Ser Ala Leu Tyr Lys 
    610                 615                 620                 


Leu Ile Asn Asp Phe Glu Ile Tyr Ala Leu Tyr Lys Asp Met Asp Thr 
625                 630                 635                 640 


Ser Glu Thr Leu Ser Gln Gln Val Asp Lys Gln Glu Tyr Lys Arg Asn 
                645                 650                 655     


Glu Tyr Phe Asn Phe Glu Thr Leu Leu Arg Lys Lys Phe Gly Asn Asp 
            660                 665                 670         


Ile Glu Lys Val Leu Val Thr Tyr Arg Asn Lys Ile Ala His Leu Asp 
        675                 680                 685             


Phe Asn Phe Leu Tyr Asp Lys Pro Ile Asn Lys Phe Ile Ser Leu Tyr 
    690                 695                 700                 


Lys Ser Arg Glu Lys Ile Val Asn Tyr Ile Lys Asn His Asp Ile Gln 
705                 710                 715                 720 


Ala Val Leu Lys Tyr Asp Ala Val Asn Asp Phe Val Met Lys Val Ile 
                725                 730                 735     


Gln Leu Arg Thr Lys Leu Lys Val Tyr Ala Asp Lys Glu Gln Thr Ile 
            740                 745                 750         


Glu Ser Met Ile Gln Asn Thr Gln Asn Pro Asn Gly Phe Tyr Asn Ile 
        755                 760                 765             


Tyr Lys Val Lys Ala Val Glu Asn Ile Asn Arg His Leu Leu Lys Val 
    770                 775                 780                 


Ile Gly Tyr Thr Glu Ser Glu Lys Ala Val Glu Glu Lys Ile Arg Ala 
785                 790                 795                 800 


Gly Asn Thr Ser Lys Ser 
                805     


<210>  43
<211>  832
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  43

Met Ile Lys Asn Pro Ser Asn Arg Tyr Ala Leu Pro Lys Val Ile Ile 
1               5                   10                  15      


Ser Lys Ile Asp Asn Gln Asn Ile Leu Glu Phe Lys Ile Lys Tyr Lys 
            20                  25                  30          


Lys Leu Ser Lys Leu Asp Ile Val Lys Val Lys Ser Met His Tyr Asp 
        35                  40                  45              


Asp Arg Ala Ile Ile Phe Asp Glu Val Ile Val Asn Asp Gly Leu Ile 
    50                  55                  60                  


Asp Val Glu Tyr Arg Asp Asn His Lys Thr Ile Phe Val Lys Val Gly 
65                  70                  75                  80  


Asn Lys Ser Tyr Ser Ile Ser Gly Gln Lys Val Gly Gly Lys Glu Arg 
                85                  90                  95      


Leu Leu Glu Asn Arg Val Ser Lys Thr Lys Val Gln Leu Glu Leu Lys 
            100                 105                 110         


Asp Lys Ala Thr Asn Arg Val Ser Lys Thr Glu Arg Glu Leu Ile Val 
        115                 120                 125             


Asp Asp Asn Ile Lys Ile Tyr Ser Gln Ile Val Gly Arg Asp Val Lys 
    130                 135                 140                 


Thr Thr Lys Asp Ile Tyr Leu Ile Lys Arg Phe Leu Ala Tyr Arg Ser 
145                 150                 155                 160 


Asp Leu Leu Phe Tyr Tyr Gly Phe Val Asn Asn Phe Phe His Val Ala 
                165                 170                 175     


Asn Asn Arg Ser Glu Phe Trp Lys Ile Asp Phe Asn Asp Ser Asn Asn 
            180                 185                 190         


Ser Lys Leu Ile Glu Tyr Phe Lys Phe Thr Ile Asn Asp His Leu Lys 
        195                 200                 205             


Asn Asp Glu Asn Tyr Leu Lys Asp Tyr Ile Ser Asp Asn Glu Lys Leu 
    210                 215                 220                 


Lys Asn Asp Leu Ile Lys Val Lys Asn Ser Phe Glu Lys Ile Arg His 
225                 230                 235                 240 


Ala Leu Met His Phe Asp Tyr Asp Phe Phe Val Lys Leu Phe Asn Gly 
                245                 250                 255     


Glu Asp Val Gly Leu Glu Leu Asp Ile Glu Phe Leu Asp Ile Met Ile 
            260                 265                 270         


Asp Lys Leu Asp Lys Leu Asn Ile Asp Thr Lys Lys Glu Phe Ile Asp 
        275                 280                 285             


Asp Glu Lys Ile Thr Ile Phe Gly Glu Glu Leu Ser Leu Ala Lys Leu 
    290                 295                 300                 


Tyr Arg Phe Tyr Ala His Thr Ala Ile Asn Arg Val Ala Phe Asn Lys 
305                 310                 315                 320 


Leu Ile Asn Ser Phe Ile Ile Glu Asn Gly Val Glu Asn Gln Ser Leu 
                325                 330                 335     


Lys Glu Tyr Phe Asn Gln Gln Ala Gly Gly Ile Ala Tyr Glu Ile Asp 
            340                 345                 350         


Ile His Gln Asn Arg Glu Tyr Lys Asn Leu Tyr Asn Glu His Lys Lys 
        355                 360                 365             


Leu Val Ser Arg Val Leu Ser Ile Ser Asp Gly Gln Glu Ile Ala Ile 
    370                 375                 380                 


Leu Asn Gln Lys Ile Ala Lys Leu Lys Asp Gln Met Lys Gln Ile Thr 
385                 390                 395                 400 


Lys Ala Asn Ser Ile Lys Arg Leu Glu Tyr Lys Leu Arg Leu Ala Leu 
                405                 410                 415     


Gly Phe Ile Tyr Thr Glu Tyr Glu Asn Tyr Glu Glu Phe Lys Asn Asn 
            420                 425                 430         


Phe Asp Thr Asp Ile Lys Asn Gly Arg Phe Thr Pro Lys Asp Asn Asp 
        435                 440                 445             


Gly Asn Lys Arg Ala Phe Asp Ser Arg Glu Leu Glu Gln Leu Lys Gly 
    450                 455                 460                 


Tyr Tyr Glu Ala Thr Ile Gln Thr Gln Lys Pro Lys Thr Asp Glu Lys 
465                 470                 475                 480 


Ile Glu Glu Val Ser Lys Lys Ile Asp Arg Leu Ser Leu Lys Ser Leu 
                485                 490                 495     


Ile Ala Asp Asp Ile Leu Leu Lys Phe Ile Leu Leu Met Phe Thr Phe 
            500                 505                 510         


Met Pro Gln Glu Leu Lys Gly Glu Phe Leu Gly Phe Ile Lys Lys Tyr 
        515                 520                 525             


Tyr His Asp Thr Lys His Ile Asp Gln Asp Thr Ile Ser Asp Ser Asp 
    530                 535                 540                 


Asp Thr Ile Glu Thr Leu Ser Ile Gly Leu Lys Leu Lys Ile Leu Asp 
545                 550                 555                 560 


Lys Asn Ile Arg Ser Leu Ser Ile Leu Lys His Ser Leu Ser Phe Gln 
                565                 570                 575     


Thr Lys Tyr Asn Lys Lys Asp Arg Asn Tyr Tyr Glu Asp Gly Asn Ile 
            580                 585                 590         


His Gly Lys Phe Phe Lys Lys Leu Gly Ile Ser His Asn Gln Glu Glu 
        595                 600                 605             


Phe Asn Lys Ser Val Tyr Ala Pro Leu Phe Arg Tyr Tyr Ser Ala Leu 
    610                 615                 620                 


Tyr Lys Leu Ile Asn Asp Phe Glu Ile Tyr Thr Leu Ser Leu His Ile 
625                 630                 635                 640 


Val Gly Ser Glu Thr Leu Thr Asp Gln Val Asn Lys Ser Gln Phe Leu 
                645                 650                 655     


Ser Gly Arg Tyr Phe Asn Phe Arg Lys Leu Leu Thr Gln Ser Tyr His 
            660                 665                 670         


Ile Asn Asn Asn Ser Thr His Ser Thr Ile Phe Asn Ala Val Ile Asn 
        675                 680                 685             


Met Arg Asn Asp Ile Ser His Leu Ser Tyr Glu Pro Leu Phe Asp Cys 
    690                 695                 700                 


Pro Leu Asn Gly Lys Lys Ser Tyr Lys Arg Lys Ile Arg Asn Gln Phe 
705                 710                 715                 720 


Lys Thr Ile Asn Ile Lys Pro Leu Val Glu Ser Arg Lys Ile Ile Ile 
                725                 730                 735     


Asp Phe Ile Thr Leu Gln Thr Asp Met Gln Lys Val Leu Gly Tyr Asp 
            740                 745                 750         


Ala Val Asn Asp Phe Thr Met Lys Ile Val Gln Leu Arg Thr Arg Leu 
        755                 760                 765             


Lys Ala Tyr Ala Asn Lys Glu Gln Thr Ile Gln Lys Met Ile Thr Glu 
    770                 775                 780                 


Ala Lys Thr Pro Asn Asp Phe Tyr Asn Ile Tyr Lys Val Gln Gly Val 
785                 790                 795                 800 


Glu Glu Ile Asn Lys Tyr Leu Leu Glu Val Ile Gly Glu Thr Gln Ala 
                805                 810                 815     


Glu Lys Glu Ile Arg Glu Lys Ile Glu Arg Gly Asn Ile Ala Asn Phe 
            820                 825                 830         


<210>  44
<211>  1281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  44

Met Lys Lys Ser Ile Phe Asp Gln Phe Val Asn Gln Tyr Ala Leu Ser 
1               5                   10                  15      


Lys Thr Leu Arg Phe Glu Leu Lys Pro Val Gly Glu Thr Gly Arg Met 
            20                  25                  30          


Leu Glu Glu Ala Lys Val Phe Ala Lys Asp Glu Thr Ile Lys Lys Lys 
        35                  40                  45              


Tyr Glu Ala Thr Lys Pro Phe Phe Asn Lys Leu His Arg Glu Phe Val 
    50                  55                  60                  


Glu Glu Ala Leu Asn Glu Val Glu Leu Ala Gly Leu Pro Glu Tyr Phe 
65                  70                  75                  80  


Glu Ile Phe Lys Tyr Trp Lys Arg Tyr Lys Lys Lys Phe Glu Lys Asp 
                85                  90                  95      


Leu Gln Lys Lys Glu Lys Glu Leu Arg Lys Ser Val Val Gly Phe Phe 
            100                 105                 110         


Asn Ala Gln Ala Lys Glu Trp Ala Lys Lys Tyr Glu Thr Leu Gly Val 
        115                 120                 125             


Lys Lys Lys Asp Val Gly Leu Leu Phe Glu Glu Asn Val Phe Ala Ile 
    130                 135                 140                 


Leu Lys Glu Arg Tyr Gly Asn Glu Glu Gly Ser Gln Ile Val Asp Glu 
145                 150                 155                 160 


Ser Thr Gly Lys Asp Val Ser Ile Phe Asp Ser Trp Lys Gly Phe Thr 
                165                 170                 175     


Gly Tyr Phe Ile Lys Phe Gln Glu Thr Arg Lys Asn Phe Tyr Lys Asp 
            180                 185                 190         


Asp Gly Thr Ala Thr Ala Leu Ala Thr Arg Ile Ile Asp Gln Asn Leu 
        195                 200                 205             


Lys Arg Phe Cys Asp Asn Leu Leu Ile Phe Glu Ser Ile Arg Asp Lys 
    210                 215                 220                 


Ile Asp Phe Ser Glu Val Glu Gln Thr Met Gly Asn Ser Ile Asp Lys 
225                 230                 235                 240 


Val Phe Ser Val Ile Phe Tyr Ser Ser Cys Leu Leu Gln Glu Gly Ile 
                245                 250                 255     


Asp Phe Tyr Asn Cys Val Leu Gly Gly Glu Thr Leu Pro Asn Gly Glu 
            260                 265                 270         


Lys Arg Gln Gly Ile Asn Glu Leu Ile Asn Leu Tyr Arg Gln Lys Thr 
        275                 280                 285             


Ser Glu Lys Val Pro Phe Leu Lys Leu Leu Asp Lys Gln Ile Leu Ser 
    290                 295                 300                 


Glu Lys Glu Lys Phe Met Asp Glu Ile Glu Asn Asp Glu Ala Leu Leu 
305                 310                 315                 320 


Asp Thr Leu Lys Ile Phe Arg Lys Ser Ala Glu Glu Lys Thr Thr Leu 
                325                 330                 335     


Leu Lys Asn Ile Phe Gly Asp Phe Val Met Asn Gln Gly Lys Tyr Asp 
            340                 345                 350         


Leu Ala Gln Ile Tyr Ile Ser Arg Glu Ser Leu Asn Thr Ile Ser Arg 
        355                 360                 365             


Lys Trp Thr Ser Glu Thr Asp Ile Phe Glu Asp Ser Leu Tyr Glu Val 
    370                 375                 380                 


Leu Lys Lys Ser Lys Ile Val Ser Ala Ser Val Lys Lys Lys Asp Gly 
385                 390                 395                 400 


Gly Tyr Ala Phe Pro Glu Phe Ile Ala Leu Ile Tyr Val Lys Ser Ala 
                405                 410                 415     


Leu Glu Gln Ile Pro Thr Glu Lys Phe Trp Lys Glu Arg Tyr Tyr Lys 
            420                 425                 430         


Asn Ile Gly Asp Val Leu Asn Lys Gly Phe Leu Asn Gly Lys Glu Gly 
        435                 440                 445             


Val Trp Leu Gln Phe Leu Leu Ile Phe Asp Phe Glu Phe Asn Ser Leu 
    450                 455                 460                 


Phe Glu Arg Glu Ile Ile Asp Glu Asn Gly Asp Lys Lys Val Ala Gly 
465                 470                 475                 480 


Tyr Asn Leu Phe Ala Lys Gly Phe Asp Asp Leu Leu Asn Asn Phe Lys 
                485                 490                 495     


Tyr Asp Gln Lys Ala Lys Val Val Ile Lys Asp Phe Ala Asp Glu Val 
            500                 505                 510         


Leu His Ile Tyr Gln Met Gly Lys Tyr Phe Ala Ile Glu Lys Lys Arg 
        515                 520                 525             


Ser Trp Leu Ala Asp Tyr Asp Ile Asp Ser Phe Tyr Thr Asp Pro Glu 
    530                 535                 540                 


Lys Gly Tyr Leu Lys Phe Tyr Glu Asn Ala Tyr Glu Glu Ile Ile Gln 
545                 550                 555                 560 


Val Tyr Asn Lys Leu Arg Asn Tyr Leu Thr Lys Lys Pro Tyr Ser Glu 
                565                 570                 575     


Asp Lys Trp Lys Leu Asn Phe Glu Asn Pro Thr Leu Ala Asp Gly Trp 
            580                 585                 590         


Asp Lys Asn Lys Glu Ala Asp Asn Ser Thr Val Ile Leu Lys Lys Asp 
        595                 600                 605             


Gly Arg Tyr Tyr Leu Gly Leu Met Ala Arg Gly Arg Asn Lys Leu Phe 
    610                 615                 620                 


Asp Asp Arg Asn Leu Pro Lys Ile Leu Glu Gly Val Glu Asn Gly Lys 
625                 630                 635                 640 


Tyr Glu Lys Val Val Tyr Lys Tyr Phe Pro Asp Gln Ala Lys Met Phe 
                645                 650                 655     


Pro Lys Val Cys Phe Ser Thr Lys Gly Leu Glu Phe Phe Gln Pro Ser 
            660                 665                 670         


Glu Glu Val Ile Thr Ile Tyr Lys Asn Ser Glu Phe Lys Lys Gly Tyr 
        675                 680                 685             


Thr Phe Asn Val Arg Ser Met Gln Arg Leu Ile Asp Phe Tyr Lys Asp 
    690                 695                 700                 


Cys Leu Val Arg Tyr Glu Gly Trp Gln Cys Tyr Asp Phe Arg Asn Leu 
705                 710                 715                 720 


Arg Lys Thr Glu Asp Tyr Arg Lys Asn Ile Glu Glu Phe Phe Ser Asp 
                725                 730                 735     


Val Ala Met Asp Gly Tyr Lys Ile Ser Phe Gln Asp Val Ser Glu Ser 
            740                 745                 750         


Tyr Ile Lys Glu Lys Asn Gln Asn Gly Asp Leu Tyr Leu Phe Glu Ile 
        755                 760                 765             


Lys Asn Lys Asp Trp Asn Glu Gly Ala Asn Gly Lys Lys Asn Leu His 
    770                 775                 780                 


Thr Ile Tyr Phe Glu Ser Leu Phe Ser Ala Asp Asn Ile Ala Met Asn 
785                 790                 795                 800 


Phe Pro Val Lys Leu Asn Gly Gln Ala Glu Ile Phe Tyr Arg Pro Arg 
                805                 810                 815     


Thr Glu Gly Leu Glu Lys Glu Arg Ile Ile Thr Lys Lys Gly Asn Val 
            820                 825                 830         


Leu Glu Lys Gly Asp Lys Ala Phe His Lys Arg Arg Tyr Thr Glu Asn 
        835                 840                 845             


Lys Val Phe Phe His Val Pro Ile Thr Leu Asn Arg Thr Lys Lys Asn 
    850                 855                 860                 


Pro Phe Gln Phe Asn Ala Lys Ile Asn Asp Phe Leu Ala Lys Asn Ser 
865                 870                 875                 880 


Asp Ile Asn Val Ile Gly Val Asp Arg Gly Glu Lys Gln Leu Ala Tyr 
                885                 890                 895     


Phe Ser Val Ile Ser Gln Arg Gly Lys Ile Leu Asp Arg Gly Ser Leu 
            900                 905                 910         


Asn Val Ile Asn Gly Val Asn Tyr Ala Glu Lys Leu Glu Glu Lys Ala 
        915                 920                 925             


Arg Gly Arg Glu Gln Ala Arg Lys Asp Trp Gln Gln Ile Glu Gly Ile 
    930                 935                 940                 


Lys Asp Leu Lys Lys Gly Tyr Ile Ser Gln Val Val Arg Lys Leu Ala 
945                 950                 955                 960 


Asp Leu Ala Ile Gln Tyr Asn Ala Ile Ile Val Phe Glu Asp Leu Asn 
                965                 970                 975     


Met Arg Phe Lys Gln Ile Arg Gly Gly Ile Glu Lys Ser Val Tyr Gln 
            980                 985                 990         


Gln Leu Glu Lys Ala Leu Ile Asp  Lys Leu Thr Phe Leu  Val Glu Lys 
        995                 1000                 1005             


Glu Glu  Lys Asp Val Glu Lys  Ala Gly His Leu Leu  Lys Ala Tyr 
    1010                 1015                 1020             


Gln Leu  Ala Ala Pro Phe Glu  Thr Phe Gln Lys Met  Gly Lys Gln 
    1025                 1030                 1035             


Thr Gly  Ile Val Phe Tyr Thr  Gln Ala Ala Tyr Thr  Ser Arg Ile 
    1040                 1045                 1050             


Asp Pro  Val Thr Gly Trp Arg  Pro His Leu Tyr Leu  Lys Tyr Ser 
    1055                 1060                 1065             


Ser Ala  Glu Lys Ala Lys Ala  Asp Leu Leu Lys Phe  Lys Lys Ile 
    1070                 1075                 1080             


Lys Phe  Val Asp Gly Arg Phe  Glu Phe Thr Tyr Asp  Ile Lys Ser 
    1085                 1090                 1095             


Phe Arg  Glu Gln Lys Glu His  Pro Lys Ala Thr Val  Trp Thr Val 
    1100                 1105                 1110             


Cys Ser  Cys Val Glu Arg Phe  Arg Trp Asn Arg Tyr  Leu Asn Ser 
    1115                 1120                 1125             


Asn Lys  Gly Gly Tyr Asp His  Tyr Ser Asp Val Thr  Lys Phe Leu 
    1130                 1135                 1140             


Val Glu  Leu Phe Gln Glu Tyr  Gly Ile Asp Phe Glu  Arg Gly Asp 
    1145                 1150                 1155             


Ile Val  Gly Gln Ile Glu Val  Leu Glu Thr Lys Gly  Asn Glu Lys 
    1160                 1165                 1170             


Phe Phe  Lys Asn Phe Val Phe  Phe Phe Asn Leu Ile  Cys Gln Ile 
    1175                 1180                 1185             


Arg Asn  Thr Asn Ala Ser Glu  Leu Ala Lys Lys Asp  Gly Lys Asp 
    1190                 1195                 1200             


Asp Phe  Ile Leu Ser Pro Val  Glu Pro Phe Phe Asp  Ser Arg Asn 
    1205                 1210                 1215             


Ser Glu  Lys Phe Gly Glu Asp  Leu Pro Lys Asn Gly  Asp Asp Asn 
    1220                 1225                 1230             


Gly Ala  Phe Asn Ile Ala Arg  Lys Gly Leu Val Ile  Met Asp Lys 
    1235                 1240                 1245             


Ile Thr  Lys Phe Ala Asp Glu  Asn Gly Gly Cys Glu  Lys Met Lys 
    1250                 1255                 1260             


Trp Gly  Asp Leu Tyr Val Ser  Asn Val Glu Trp Asp  Asn Phe Val 
    1265                 1270                 1275             


Ala Asn  Lys 
    1280     


<210>  45
<211>  1280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  45

Met Phe Asn Asn Phe Ile Lys Lys Tyr Ser Leu Gln Lys Thr Leu Arg 
1               5                   10                  15      


Phe Glu Leu Lys Pro Val Gly Glu Thr Ala Asp Tyr Ile Glu Asp Phe 
            20                  25                  30          


Lys Ser Glu Tyr Leu Lys Asp Thr Val Leu Lys Asp Glu Gln Arg Ala 
        35                  40                  45              


Lys Asp Tyr Gln Glu Ile Lys Thr Leu Ile Asp Asp Tyr His Arg Glu 
    50                  55                  60                  


Tyr Ile Glu Glu Cys Leu Arg Glu Pro Val Asp Lys Lys Thr Gly Glu 
65                  70                  75                  80  


Ile Leu Asp Phe Thr Gln Asp Leu Glu Asp Ala Phe Ser Tyr Tyr Gln 
                85                  90                  95      


Lys Leu Lys Glu Asn Pro Thr Glu Asn Arg Val Gly Trp Glu Lys Glu 
            100                 105                 110         


Gln Glu Ser Leu Arg Lys Lys Leu Val Thr Ser Phe Val Gly Asn Asp 
        115                 120                 125             


Gly Leu Phe Lys Lys Glu Phe Ile Thr Arg Asp Leu Pro Glu Trp Leu 
    130                 135                 140                 


Gln Lys Lys Gly Leu Trp Gly Glu Tyr Lys Asp Thr Val Glu Asn Phe 
145                 150                 155                 160 


Lys Lys Phe Thr Thr Tyr Phe Ser Gly Phe His Glu Asn Arg Lys Asn 
                165                 170                 175     


Met Tyr Thr Ala Glu Ala Gln Ser Thr Ala Ile Ala Asn Arg Leu Met 
            180                 185                 190         


Asn Asp Asn Leu Pro Lys Phe Phe Asn Asn Tyr Leu Ala Tyr Gln Thr 
        195                 200                 205             


Ile Lys Glu Lys His Pro Asp Leu Val Phe Arg Leu Asp Asp Ala Leu 
    210                 215                 220                 


Leu Gln Ala Ala Gly Val Glu His Leu Asp Glu Ala Phe Gln Pro Arg 
225                 230                 235                 240 


Tyr Phe Ser Arg Leu Phe Ala Gln Ser Gly Ile Thr Ala Phe Asn Glu 
                245                 250                 255     


Leu Ile Gly Gly Arg Thr Thr Glu Asn Gly Glu Lys Ile Gln Gly Leu 
            260                 265                 270         


Asn Glu Gln Ile Asn Leu Tyr Arg Gln Gln Asn Pro Glu Lys Ala Lys 
        275                 280                 285             


Gly Phe Pro Arg Phe Met Pro Leu Phe Lys Gln Ile Leu Ser Asp Arg 
    290                 295                 300                 


Glu Thr His Ser Phe Leu Pro Asp Ala Phe Glu Asn Asp Lys Glu Leu 
305                 310                 315                 320 


Leu Gln Ala Leu Arg Asp Tyr Val Asp Ala Ala Thr Ser Glu Glu Gly 
                325                 330                 335     


Met Ile Ser Gln Leu Asn Lys Ala Met Asn Gln Phe Val Thr Ala Asp 
            340                 345                 350         


Leu Lys Arg Val Tyr Ile Lys Ser Ala Ala Leu Thr Ser Leu Ser Gln 
        355                 360                 365             


Glu Leu Phe His Phe Phe Gly Val Ile Ser Asp Ala Ile Ala Trp Tyr 
    370                 375                 380                 


Ala Glu Lys Arg Leu Ser Pro Lys Lys Ala Gln Glu Ser Phe Leu Lys 
385                 390                 395                 400 


Gln Glu Val Tyr Ala Ile Glu Glu Leu Asn Gln Ala Val Val Gly Tyr 
                405                 410                 415     


Ile Asp Gln Leu Glu Asp Gln Ser Glu Leu Gln Gln Leu Leu Val Asp 
            420                 425                 430         


Leu Pro Asp Pro Gln Lys Pro Val Ser Ser Phe Ile Leu Thr His Trp 
        435                 440                 445             


Gln Lys Ser Gln Glu Pro Leu Gln Ala Val Ile Ala Lys Val Glu Pro 
    450                 455                 460                 


Leu Phe Glu Leu Glu Glu Leu Ser Lys Asn Lys Arg Ala Pro Lys His 
465                 470                 475                 480 


Asp Lys Asp Gln Gly Gly Glu Gly Phe Gln Gln Val Asp Ala Ile Lys 
                485                 490                 495     


Asn Met Leu Asp Ala Phe Met Glu Val Ser His Ala Ile Lys Pro Leu 
            500                 505                 510         


Tyr Leu Val Lys Gly Arg Lys Ala Ile Asp Met Pro Asp Val Asp Thr 
        515                 520                 525             


Gly Phe Tyr Ala Asp Phe Ala Glu Ala Tyr Ser Ala Tyr Glu Gln Val 
    530                 535                 540                 


Thr Val Ser Leu Tyr Asn Lys Thr Arg Asn His Leu Ser Lys Lys Pro 
545                 550                 555                 560 


Phe Ser Lys Asp Lys Ile Lys Ile Asn Phe Asp Ala Pro Thr Leu Leu 
                565                 570                 575     


Asn Gly Trp Asp Leu Asn Lys Glu Ser Asp Asn Lys Ser Ile Ile Leu 
            580                 585                 590         


Arg Lys Asp Gly Asn Phe Tyr Leu Ala Ile Met His Pro Lys His Thr 
        595                 600                 605             


Lys Val Phe Asp Cys Tyr Ser Ala Ser Glu Ala Ala Gly Lys Cys Tyr 
    610                 615                 620                 


Glu Lys Met Asn Tyr Lys Leu Leu Ser Gly Ala Asn Lys Met Leu Pro 
625                 630                 635                 640 


Lys Val Phe Phe Ser Lys Lys Gly Ile Glu Thr Phe Ser Pro Pro Gln 
                645                 650                 655     


Glu Ile Leu Asp Leu Tyr Lys Asn Asn Glu His Lys Lys Gly Ala Thr 
            660                 665                 670         


Phe Lys Leu Glu Ser Cys His Lys Leu Ile Asp Phe Phe Lys Arg Asn 
        675                 680                 685             


Ile Pro Lys Tyr Lys Val His Pro Thr Asp Asn Phe Gly Trp Asp Val 
    690                 695                 700                 


Phe Gly Phe His Phe Ser Pro Thr Ser Ser Tyr Gly Asp Leu Ser Gly 
705                 710                 715                 720 


Phe Tyr Arg Glu Val Glu Ala Gln Gly Tyr Lys Leu Trp Phe Ser Asp 
                725                 730                 735     


Val Ser Glu Ala Tyr Ile Asn Lys Cys Val Glu Glu Gly Lys Leu Phe 
            740                 745                 750         


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Pro Asn Ser Thr Gly Lys 
        755                 760                 765             


Pro Asn Leu His Thr Leu Tyr Trp Lys Gly Leu Phe Glu Pro Glu Asn 
    770                 775                 780                 


Leu Lys Asp Val Val Leu Lys Leu Asn Gly Glu Ala Glu Ile Phe Tyr 
785                 790                 795                 800 


Arg Lys His Ser Ile Lys His Glu Asp Lys Thr Ile His Arg Ala Lys 
                805                 810                 815     


Asp Pro Ile Ala Asn Lys Asn Ala Asp Asn Pro Lys Lys Gln Ser Val 
            820                 825                 830         


Phe Asp Tyr Asp Ile Ile Lys Asp Lys Arg Tyr Thr Gln Asp Lys Phe 
        835                 840                 845             


Phe Phe His Val Pro Ile Ser Leu Asn Phe Lys Ser Gln Gly Val Val 
    850                 855                 860                 


Arg Phe Asn Asp Lys Ile Asn Gly Leu Leu Ala Ala Gln Asp Asp Val 
865                 870                 875                 880 


His Val Ile Gly Ile Asp Arg Gly Glu Arg His Leu Leu Tyr Tyr Thr 
                885                 890                 895     


Val Val Asn Gly Lys Gly Glu Val Val Glu Gln Gly Ser Leu Asn Gln 
            900                 905                 910         


Val Ala Thr Asp Gln Gly Tyr Val Val Asp Tyr Gln Gln Lys Leu His 
        915                 920                 925             


Ala Lys Glu Lys Glu Arg Asp Gln Ala Arg Lys Asn Trp Ser Thr Ile 
    930                 935                 940                 


Glu Asn Ile Lys Glu Leu Lys Ala Gly Tyr Leu Ser Gln Val Val His 
945                 950                 955                 960 


Lys Leu Ala Gln Leu Ile Val Lys His Asn Ala Ile Val Cys Leu Glu 
                965                 970                 975     


Asp Leu Asn Phe Gly Phe Lys Arg Gly Arg Phe Lys Val Glu Lys Gln 
            980                 985                 990         


Val Tyr Gln Lys Phe Glu Lys Ala  Leu Ile Asp Lys Leu  Asn Tyr Leu 
        995                 1000                 1005             


Val Phe  Lys Glu Arg Gly Ala  Thr Gln Ala Gly Gly  Tyr Leu Asn 
    1010                 1015                 1020             


Ala Tyr  Gln Leu Ala Ala Pro  Phe Glu Ser Phe Glu  Lys Leu Gly 
    1025                 1030                 1035             


Lys Gln  Thr Gly Ile Leu Tyr  Tyr Val Arg Ser Asp  Tyr Thr Ser 
    1040                 1045                 1050             


Lys Ile  Asp Pro Ala Thr Gly  Phe Val Asp Phe Leu  Lys Pro Lys 
    1055                 1060                 1065             


Tyr Glu  Ser Met Ala Lys Ser  Lys Val Phe Phe Glu  Ser Phe Glu 
    1070                 1075                 1080             


Arg Ile  Gln Trp Asn Gln Ala  Lys Gly Tyr Phe Glu  Phe Glu Phe 
    1085                 1090                 1095             


Asp Tyr  Lys Lys Met Cys Pro  Ser Arg Lys Phe Gly  Asp Tyr Arg 
    1100                 1105                 1110             


Thr Arg  Trp Val Val Cys Thr  Phe Gly Asp Thr Arg  Tyr Gln Asn 
    1115                 1120                 1125             


Arg Arg  Asn Lys Ser Ser Gly  Gln Trp Glu Thr Glu  Thr Ile Asp 
    1130                 1135                 1140             


Val Thr  Ala Gln Leu Lys Ala  Leu Phe Ala Ala Tyr  Gly Ile Thr 
    1145                 1150                 1155             


Tyr Asn  Gln Glu Asp Asn Ile  Lys Asp Ala Ile Ala  Ala Val Lys 
    1160                 1165                 1170             


Tyr Thr  Lys Phe Tyr Lys Gln  Leu Tyr Trp Leu Leu  Arg Leu Thr 
    1175                 1180                 1185             


Leu Ser  Leu Arg His Ser Val  Thr Gly Thr Asp Glu  Asp Phe Ile 
    1190                 1195                 1200             


Leu Ser  Pro Val Ala Asp Glu  Asn Gly Val Phe Phe  Asp Ser Arg 
    1205                 1210                 1215             


Lys Ala  Thr Asp Lys Gln Pro  Lys Asp Ala Asp Ala  Asn Gly Ala 
    1220                 1225                 1230             


Tyr His  Ile Ala Leu Lys Gly  Leu Trp Asn Leu Gln  Gln Ile Arg 
    1235                 1240                 1245             


Gln His  Asp Trp Asn Val Glu  Lys Pro Lys Lys Leu  Asn Leu Ala 
    1250                 1255                 1260             


Met Lys  Asn Glu Glu Trp Phe  Gly Phe Ala Gln Lys  Lys Lys Phe 
    1265                 1270                 1275             


Arg Ala  
    1280 


<210>  46
<211>  832
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  46

Met Ile Lys Asn Pro Ser Asn Arg Tyr Ala Leu Pro Lys Val Ile Ile 
1               5                   10                  15      


Ser Lys Ile Asp Asn Gln Asn Ile Leu Glu Phe Lys Ile Lys Tyr Lys 
            20                  25                  30          


Lys Leu Ser Lys Leu Asp Ile Val Lys Val Lys Ser Met His Tyr Asp 
        35                  40                  45              


Asp Arg Ala Ile Ile Phe Asp Glu Val Ile Val Asn Asp Gly Leu Ile 
    50                  55                  60                  


Asp Val Glu Tyr Arg Asp Asn His Lys Thr Ile Phe Val Lys Val Gly 
65                  70                  75                  80  


Asn Lys Ser Tyr Ser Ile Ser Gly Gln Lys Val Gly Gly Lys Glu Arg 
                85                  90                  95      


Leu Leu Glu Asn Arg Val Ser Lys Thr Lys Val Gln Leu Glu Leu Lys 
            100                 105                 110         


Asp Lys Ala Thr Asn Arg Val Ser Lys Thr Glu Arg Glu Leu Ile Val 
        115                 120                 125             


Asp Asp Asn Ile Lys Ile Tyr Ser Gln Ile Val Gly Arg Asp Val Lys 
    130                 135                 140                 


Thr Thr Lys Asp Ile Tyr Leu Ile Lys Arg Phe Leu Ala Tyr Arg Ser 
145                 150                 155                 160 


Asp Leu Leu Phe Tyr Tyr Gly Phe Val Asn Asn Phe Phe His Val Ala 
                165                 170                 175     


Asn Asn Arg Ser Glu Phe Trp Lys Ile Asp Phe Asn Asp Ser Asn Asn 
            180                 185                 190         


Ser Lys Leu Ile Glu Tyr Phe Lys Phe Thr Ile Asn Asp His Leu Lys 
        195                 200                 205             


Asn Asp Glu Asn Tyr Leu Lys Asp Tyr Ile Ser Asp Asn Glu Lys Leu 
    210                 215                 220                 


Lys Asn Asp Leu Ile Lys Val Lys Asn Ser Phe Glu Lys Ile Arg His 
225                 230                 235                 240 


Ala Leu Met His Phe Asp Tyr Asp Phe Phe Val Lys Leu Phe Asn Gly 
                245                 250                 255     


Glu Asp Val Gly Leu Glu Leu Asp Ile Glu Phe Leu Asp Ile Met Ile 
            260                 265                 270         


Asp Lys Leu Asp Lys Leu Asn Ile Asp Thr Lys Lys Glu Phe Ile Asp 
        275                 280                 285             


Asp Glu Lys Ile Thr Ile Phe Gly Glu Glu Leu Ser Leu Ala Lys Leu 
    290                 295                 300                 


Tyr Arg Phe Tyr Ala His Thr Ala Ile Asn Arg Val Ala Phe Asn Lys 
305                 310                 315                 320 


Leu Ile Asn Ser Phe Ile Ile Glu Asn Gly Val Glu Asn Gln Ser Leu 
                325                 330                 335     


Lys Glu Tyr Phe Asn Gln Gln Ala Gly Gly Ile Ala Tyr Glu Ile Asp 
            340                 345                 350         


Ile His Gln Asn Arg Glu Tyr Lys Asn Leu Tyr Asn Glu His Lys Lys 
        355                 360                 365             


Leu Val Ser Arg Val Leu Ser Ile Ser Asp Gly Gln Glu Ile Ala Ile 
    370                 375                 380                 


Leu Asn Gln Lys Ile Ala Lys Leu Lys Asp Gln Met Lys Gln Ile Thr 
385                 390                 395                 400 


Lys Ala Asn Ser Ile Lys Arg Leu Glu Tyr Lys Leu Arg Leu Ala Leu 
                405                 410                 415     


Gly Phe Ile Tyr Thr Glu Tyr Glu Asn Tyr Glu Glu Phe Lys Asn Asn 
            420                 425                 430         


Phe Asp Thr Asp Ile Lys Asn Gly Arg Phe Thr Pro Lys Asp Asn Asp 
        435                 440                 445             


Gly Asn Lys Arg Ala Phe Asp Ser Arg Glu Leu Glu Gln Leu Lys Gly 
    450                 455                 460                 


Tyr Tyr Glu Ala Thr Ile Gln Thr Gln Lys Pro Lys Thr Asp Glu Lys 
465                 470                 475                 480 


Ile Glu Glu Val Ser Lys Lys Ile Asp Arg Leu Ser Leu Lys Ser Leu 
                485                 490                 495     


Ile Ala Asp Asp Ile Leu Leu Lys Phe Ile Leu Leu Met Phe Thr Phe 
            500                 505                 510         


Met Pro Gln Glu Leu Lys Gly Glu Phe Leu Gly Phe Ile Lys Lys Tyr 
        515                 520                 525             


Tyr His Asp Thr Lys His Ile Asp Gln Asp Thr Ile Ser Asp Ser Asp 
    530                 535                 540                 


Asp Thr Ile Glu Thr Leu Ser Ile Gly Leu Lys Leu Lys Ile Leu Asp 
545                 550                 555                 560 


Lys Asn Ile Arg Ser Leu Ser Ile Leu Lys His Ser Leu Ser Phe Gln 
                565                 570                 575     


Thr Lys Tyr Asn Lys Lys Asp Arg Asn Tyr Tyr Glu Asp Gly Asn Ile 
            580                 585                 590         


His Gly Lys Phe Phe Lys Lys Leu Gly Ile Ser His Asn Gln Glu Glu 
        595                 600                 605             


Phe Asn Lys Ser Val Tyr Ala Pro Leu Phe Arg Tyr Tyr Ser Ala Leu 
    610                 615                 620                 


Tyr Lys Leu Ile Asn Asp Phe Glu Ile Tyr Thr Leu Ser Leu His Ile 
625                 630                 635                 640 


Val Gly Ser Glu Thr Leu Thr Asp Gln Val Asn Lys Ser Gln Phe Leu 
                645                 650                 655     


Ser Gly Arg Tyr Phe Asn Phe Arg Lys Leu Leu Thr Gln Ser Tyr His 
            660                 665                 670         


Ile Asn Asn Asn Ser Thr His Ser Thr Ile Phe Asn Ala Val Ile Asn 
        675                 680                 685             


Met Arg Asn Asp Ile Ser His Leu Ser Tyr Glu Pro Leu Phe Asp Cys 
    690                 695                 700                 


Pro Leu Asn Gly Lys Lys Ser Tyr Lys Arg Lys Ile Arg Asn Gln Phe 
705                 710                 715                 720 


Lys Thr Ile Asn Ile Lys Pro Leu Val Glu Ser Arg Lys Ile Ile Ile 
                725                 730                 735     


Asp Phe Ile Thr Leu Gln Thr Asp Met Gln Lys Val Leu Gly Tyr Asp 
            740                 745                 750         


Ala Val Asn Asp Phe Thr Met Lys Ile Val Gln Leu Arg Thr Arg Leu 
        755                 760                 765             


Lys Ala Tyr Ala Asn Lys Glu Gln Thr Ile Gln Lys Met Ile Thr Glu 
    770                 775                 780                 


Ala Lys Thr Pro Asn Asp Phe Tyr Asn Ile Tyr Lys Val Gln Gly Val 
785                 790                 795                 800 


Glu Glu Ile Asn Lys Tyr Leu Leu Glu Val Ile Gly Glu Thr Gln Ala 
                805                 810                 815     


Glu Lys Glu Ile Arg Glu Lys Ile Glu Arg Gly Asn Ile Ala Asn Phe 
            820                 825                 830         


<210>  47
<211>  809
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  47

Met Ile Lys Asn Pro Ser Asn Arg His Ser Leu Pro Lys Val Ile Ile 
1               5                   10                  15      


Ser Glu Val Asp His Glu Lys Ile Leu Glu Phe Lys Ile Lys Tyr Glu 
            20                  25                  30          


Lys Leu Ala Arg Leu Asp Arg Phe Glu Val Lys Ala Met His Tyr Glu 
        35                  40                  45              


Gly Lys Glu Ile Val Phe Asp Glu Val Leu Val Asn Gly Gly Leu Ile 
    50                  55                  60                  


Glu Val Glu Tyr Gln Asp Asp Asn Lys Thr Leu Phe Val Lys Val Gly 
65                  70                  75                  80  


Glu Lys Ser Tyr Ser Ile Arg Gly Lys Lys Val Gly Gly Lys Gln Arg 
                85                  90                  95      


Leu Leu Glu Asp Arg Val Ser Lys Thr Lys Val Gln Leu Glu Leu Ser 
            100                 105                 110         


Asp Gly Val Val Asp Asn Lys Gly Asn Leu Arg Lys Ser Arg Thr Glu 
        115                 120                 125             


Arg Glu Leu Ile Val Ala Asp Asn Ile Lys Leu Tyr Ser Gln Ile Val 
    130                 135                 140                 


Gly Arg Glu Val Thr Thr Thr Lys Glu Ile Tyr Leu Val Lys Arg Phe 
145                 150                 155                 160 


Leu Ala Tyr Arg Ser Asp Leu Leu Phe Tyr Tyr Ser Phe Val Asp Asn 
                165                 170                 175     


Phe Phe Lys Val Ala Gly Asn Glu Lys Glu Leu Trp Lys Ile Asn Phe 
            180                 185                 190         


Asp Asp Ala Thr Ser Ala Gln Phe Met Gly Tyr Ile Pro Phe Met Val 
        195                 200                 205             


Asn Asp Asn Leu Lys Asn Asp Asn Ala Tyr Leu Lys Asp Tyr Val Arg 
    210                 215                 220                 


Asn Asp Val Gln Ile Lys Asp Asp Leu Lys Lys Val Gln Thr Ile Phe 
225                 230                 235                 240 


Ser Ala Leu Arg His Thr Leu Leu His Phe Asn Tyr Glu Phe Phe Glu 
                245                 250                 255     


Lys Leu Phe Asn Gly Glu Asp Val Gly Phe Asp Phe Asp Ile Gly Phe 
            260                 265                 270         


Leu Asn Leu Leu Ile Glu Asn Ile Asp Lys Leu Asn Ile Asp Ala Lys 
        275                 280                 285             


Lys Glu Phe Ile Asp Asn Glu Lys Ile Arg Leu Phe Gly Glu Asn Leu 
    290                 295                 300                 


Ser Leu Ala Lys Val Tyr Arg Leu Tyr Ser Asp Ile Cys Val Asn Arg 
305                 310                 315                 320 


Val Gly Phe Asn Lys Phe Ile Asn Ser Met Leu Ile Lys Asp Gly Val 
                325                 330                 335     


Glu Asn Gln Val Leu Lys Ala Glu Phe Asn Arg Lys Phe Gly Gly Asn 
            340                 345                 350         


Ala Tyr Thr Ile Asp Ile His Ser Asn Gln Glu Tyr Lys Arg Ile Tyr 
        355                 360                 365             


Asn Glu His Lys Lys Leu Val Ile Lys Val Ser Thr Leu Lys Asp Gly 
    370                 375                 380                 


Gln Ala Ile Arg Arg Gly Asn Lys Lys Ile Ser Glu Leu Lys Glu Gln 
385                 390                 395                 400 


Met Lys Ser Met Thr Lys Lys Asn Ser Leu Ala Arg Leu Glu Cys Lys 
                405                 410                 415     


Met Arg Leu Ala Phe Gly Phe Leu Tyr Gly Glu Tyr Asn Asn Tyr Lys 
            420                 425                 430         


Ala Phe Lys Asn Asn Phe Asp Thr Asn Ile Lys Asn Ser Gln Phe Asp 
        435                 440                 445             


Val Asn Asp Val Glu Lys Ser Lys Ala Tyr Phe Leu Ser Thr Tyr Glu 
    450                 455                 460                 


Arg Arg Lys Pro Arg Thr Arg Glu Lys Leu Glu Lys Val Ala Lys Asp 
465                 470                 475                 480 


Ile Glu Ser Leu Glu Leu Lys Thr Val Ile Ala Asn Asp Thr Leu Leu 
                485                 490                 495     


Lys Phe Ile Leu Leu Met Phe Val Phe Met Pro Gln Glu Leu Lys Gly 
            500                 505                 510         


Asp Phe Leu Gly Phe Val Lys Lys Tyr Tyr His Asp Val His Ser Ile 
        515                 520                 525             


Asp Asp Asp Thr Lys Glu Gln Glu Glu Asp Val Val Glu Ala Met Ser 
    530                 535                 540                 


Thr Ser Leu Lys Leu Lys Ile Leu Gly Arg Asn Ile Arg Ser Leu Thr 
545                 550                 555                 560 


Leu Phe Lys Tyr Ala Leu Ser Ser Gln Val Asn Tyr Asn Ser Thr Asp 
                565                 570                 575     


Asn Ile Phe Tyr Val Glu Gly Asn Arg Tyr Gly Lys Ile Tyr Lys Lys 
            580                 585                 590         


Leu Gly Ile Ser His Asn Gln Glu Glu Phe Asp Lys Thr Leu Val Val 
        595                 600                 605             


Pro Leu Leu Arg Tyr Tyr Ser Ser Leu Phe Lys Leu Met Asn Asp Phe 
    610                 615                 620                 


Glu Ile Tyr Ser Leu Ala Lys Ala Asn Pro Thr Ala Val Ser Leu Gln 
625                 630                 635                 640 


Glu Leu Val Asp Asp Glu Thr Ser Pro Tyr Lys Gln Gly Asn Tyr Phe 
                645                 650                 655     


Asn Phe Asn Lys Met Leu Arg Asp Ile Tyr Gly Leu Thr Ser Asp Glu 
            660                 665                 670         


Ile Lys Ser Gly Gln Val Val Phe Met Arg Asn Lys Ile Ala His Phe 
        675                 680                 685             


Asp Thr Glu Val Leu Leu Ser Lys Pro Leu Leu Gly Gln Thr Lys Met 
    690                 695                 700                 


Asn Leu Gln Arg Lys Asp Ile Val Ser Phe Ile Glu Ala Arg Gly Asp 
705                 710                 715                 720 


Ile Lys Glu Leu Leu Gly Tyr Asp Ala Ile Asn Asp Phe Arg Met Lys 
                725                 730                 735     


Val Ile His Leu Arg Thr Lys Met Arg Val Tyr Ser Asp Lys Leu Gln 
            740                 745                 750         


Thr Met Met Asp Leu Leu Arg Asn Ala Lys Thr Pro Asn Asp Phe Tyr 
        755                 760                 765             


Asn Val Tyr Lys Val Lys Gly Val Glu Ser Ile Asn Lys His Leu Leu 
    770                 775                 780                 


Glu Val Leu Ala Gln Thr Ala Glu Glu Arg Thr Val Glu Lys Gln Ile 
785                 790                 795                 800 


Arg Asp Gly Asn Glu Lys Tyr Asp Leu 
                805                 


<210>  48
<211>  1285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  48

Met Glu Glu Lys Met Leu Lys Ser Tyr Asp Tyr Phe Thr Lys Leu Tyr 
1               5                   10                  15      


Ser Leu Gln Lys Thr Leu Arg Phe Glu Leu Lys Pro Ile Gly Lys Thr 
            20                  25                  30          


Leu Glu His Ile Lys Asn Ser Gly Ile Ile Glu Ser Asp Glu Thr Leu 
        35                  40                  45              


Glu Glu Gln Tyr Ala Ile Val Lys Asn Ile Ile Asp Lys Leu His Arg 
    50                  55                  60                  


Lys His Ile Asp Glu Ala Leu Ser Leu Val Asp Phe Thr Lys His Leu 
65                  70                  75                  80  


Asp Thr Leu Lys Thr Phe Gln Glu Leu Tyr Leu Lys Arg Gly Lys Thr 
                85                  90                  95      


Asp Lys Glu Lys Glu Glu Leu Glu Lys Leu Ser Ala Asp Leu Arg Lys 
            100                 105                 110         


Leu Ile Val Ser Tyr Leu Lys Gly Asn Val Lys Glu Lys Thr Gln His 
        115                 120                 125             


Asn Leu Asn Pro Ile Lys Glu Arg Phe Glu Ile Leu Phe Gly Lys Glu 
    130                 135                 140                 


Leu Phe Thr Asn Glu Glu Phe Phe Leu Leu Ala Glu Asn Glu Lys Glu 
145                 150                 155                 160 


Lys Lys Ala Ile Gln Ala Phe Lys Gly Phe Thr Thr Tyr Phe Lys Gly 
                165                 170                 175     


Phe Gln Glu Asn Arg Lys Asn Met Tyr Ser Glu Glu Gly Asn Ser Thr 
            180                 185                 190         


Ser Ile Ala Tyr Arg Ile Ile Asn Glu Asn Leu Pro Leu Phe Ile Glu 
        195                 200                 205             


Asn Ile Ala Arg Phe Gln Lys Val Met Ser Thr Ile Glu Lys Thr Thr 
    210                 215                 220                 


Ile Lys Lys Leu Glu Gln Asn Leu Lys Thr Glu Leu Lys Lys His Asn 
225                 230                 235                 240 


Leu Pro Gly Ile Phe Thr Ile Glu Tyr Phe Asn Asn Val Leu Thr Gln 
                245                 250                 255     


Glu Gly Ile Ser Arg Tyr Asn Thr Ile Ile Gly Gly Lys Thr Thr His 
            260                 265                 270         


Glu Gly Val Lys Ile Gln Gly Leu Asn Glu Ile Ile Asn Leu Tyr Asn 
        275                 280                 285             


Gln Gln Ser Lys Asp Val Lys Leu Pro Ile Leu Lys Pro Leu His Lys 
    290                 295                 300                 


Gln Ile Leu Ser Glu Glu Tyr Ser Thr Ser Phe Lys Ile Lys Ala Phe 
305                 310                 315                 320 


Glu Asn Asp Asn Glu Val Leu Lys Ala Ile Asp Thr Phe Trp Asn Glu 
                325                 330                 335     


His Ile Glu Lys Ser Ile His Pro Val Thr Gly Asn Lys Phe Asn Ile 
            340                 345                 350         


Leu Ser Lys Ile Glu Asn Leu Cys Asp Gln Leu Gln Lys Tyr Lys Asp 
        355                 360                 365             


Lys Asp Leu Glu Lys Leu Phe Ile Glu Arg Lys Asn Leu Ser Thr Val 
    370                 375                 380                 


Ser His Gln Val Tyr Gly Gln Trp Asn Ile Ile Arg Asp Ala Leu Arg 
385                 390                 395                 400 


Met His Leu Glu Met Asn Asn Lys Asn Ile Lys Glu Lys Asp Ile Asp 
                405                 410                 415     


Lys Tyr Leu Asp Asn Asp Ala Phe Ser Trp Lys Glu Ile Lys Asp Ser 
            420                 425                 430         


Ile Lys Ile Tyr Lys Glu His Val Glu Asp Ala Lys Glu Leu Asn Glu 
        435                 440                 445             


Asn Gly Ile Ile Lys Tyr Phe Ser Ala Met Ser Ile Asn Glu Glu Asp 
    450                 455                 460                 


Asp Glu Lys Glu Tyr Ser Ile Ser Leu Ile Lys Asn Ile Asn Glu Lys 
465                 470                 475                 480 


Tyr Asn Asn Val Lys Ser Ile Leu Gln Glu Asp Arg Thr Gly Lys Ser 
                485                 490                 495     


Asp Leu His Gln Asp Lys Glu Lys Val Gly Ile Ile Lys Glu Phe Leu 
            500                 505                 510         


Asp Ser Leu Lys Gln Leu Gln Trp Phe Leu Arg Leu Leu Tyr Val Thr 
        515                 520                 525             


Val Pro Leu Asp Glu Lys Asp Tyr Glu Phe Tyr Asn Glu Leu Glu Val 
    530                 535                 540                 


Tyr Tyr Glu Ala Leu Leu Pro Leu Asn Ser Leu Tyr Asn Lys Val Arg 
545                 550                 555                 560 


Asn Tyr Met Thr Arg Lys Pro Tyr Ser Val Glu Lys Phe Lys Leu Asn 
                565                 570                 575     


Phe Asn Ser Pro Thr Leu Leu Asp Gly Trp Asp Lys Asn Lys Glu Thr 
            580                 585                 590         


Ala Asn Leu Ser Ile Ile Leu Arg Lys Asn Gly Lys Tyr Tyr Leu Gly 
        595                 600                 605             


Ile Met Asn Lys Glu Asn Asn Thr Ile Phe Glu Tyr Tyr Pro Gly Thr 
    610                 615                 620                 


Lys Ser Asn Asp Tyr Tyr Glu Lys Met Ile Tyr Lys Leu Leu Pro Gly 
625                 630                 635                 640 


Pro Asn Lys Met Leu Pro Lys Val Phe Phe Ser Lys Lys Gly Leu Glu 
                645                 650                 655     


Tyr Tyr Asn Pro Pro Lys Glu Ile Leu Asn Ile Tyr Glu Lys Gly Glu 
            660                 665                 670         


Phe Lys Lys Asp Lys Ser Gly Asn Phe Lys Lys Glu Ser Leu His Thr 
        675                 680                 685             


Leu Ile Asp Phe Tyr Lys Glu Ala Ile Ala Lys Asn Glu Asp Trp Glu 
    690                 695                 700                 


Val Phe Asn Phe Lys Phe Lys Asn Thr Lys Glu Tyr Glu Asp Ile Ser 
705                 710                 715                 720 


Gln Phe Tyr Arg Asp Val Glu Glu Gln Gly Tyr Leu Ile Thr Phe Glu 
                725                 730                 735     


Lys Val Asp Ala Asn Tyr Val Asp Lys Leu Val Lys Glu Gly Lys Leu 
            740                 745                 750         


Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Glu Asn Lys Lys Ser 
        755                 760                 765             


Lys Gly Asn Pro Asn Leu His Thr Ile Tyr Trp Lys Gly Leu Tyr Asp 
    770                 775                 780                 


Ser Glu Asn Leu Lys Asn Val Val Tyr Lys Leu Asn Gly Glu Ala Glu 
785                 790                 795                 800 


Val Phe Tyr Arg Lys Lys Ser Ile Asp Tyr Pro Glu Glu Ile Tyr Asn 
                805                 810                 815     


His Gly His His Lys Glu Glu Leu Leu Gly Lys Phe Asn Tyr Pro Ile 
            820                 825                 830         


Ile Lys Asp Arg Arg Tyr Thr Gln Asp Lys Phe Leu Phe His Val Pro 
        835                 840                 845             


Ile Thr Met Asn Phe Ile Ser Lys Glu Glu Lys Arg Val Asn Gln Leu 
    850                 855                 860                 


Ala Cys Glu Tyr Leu Ser Ala Thr Lys Glu Asp Val His Ile Ile Gly 
865                 870                 875                 880 


Ile Asp Arg Gly Glu Arg His Leu Leu Tyr Leu Ser Leu Ile Asp Lys 
                885                 890                 895     


Glu Gly Asn Ile Lys Lys Gln Leu Ser Leu Asn Thr Ile Lys Asn Glu 
            900                 905                 910         


Asn Tyr Asp Lys Glu Ile Asp Tyr Arg Val Lys Leu Asp Glu Lys Glu 
        915                 920                 925             


Lys Lys Arg Asp Glu Ala Arg Lys Asn Trp Asp Val Ile Glu Asn Ile 
    930                 935                 940                 


Lys Glu Leu Lys Glu Gly Tyr Met Ser Gln Val Ile His Ile Ile Ala 
945                 950                 955                 960 


Lys Met Met Val Glu Glu Lys Ala Ile Leu Ile Met Glu Asp Leu Asn 
                965                 970                 975     


Ile Gly Phe Lys Arg Gly Arg Phe Lys Val Glu Lys Gln Val Tyr Gln 
            980                 985                 990         


Lys Phe Glu Lys Met Leu Ile Asp  Lys Leu Asn Tyr Leu  Val Phe Lys 
        995                 1000                 1005             


Asn Lys  Asn Pro Leu Glu Pro  Gly Gly Ser Leu Asn  Ala Tyr Gln 
    1010                 1015                 1020             


Leu Thr  Ser Lys Phe Asp Ser  Phe Lys Lys Leu Gly  Lys Gln Ser 
    1025                 1030                 1035             


Gly Phe  Ile Phe Tyr Val Pro  Ser Ala Tyr Thr Ser  Lys Ile Asp 
    1040                 1045                 1050             


Pro Thr  Thr Gly Phe Tyr Asn  Phe Ile Gln Val Asp  Val Pro Asn 
    1055                 1060                 1065             


Leu Glu  Lys Gly Lys Glu Phe  Phe Ser Lys Phe Glu  Lys Ile Ile 
    1070                 1075                 1080             


Tyr Asn  Thr Lys Glu Asp Tyr  Phe Glu Phe His Cys  Lys Tyr Gly 
    1085                 1090                 1095             


Lys Phe  Val Ser Glu Pro Lys  Asn Lys Asp Asn Asp  Arg Lys Thr 
    1100                 1105                 1110             


Lys Glu  Ser Leu Thr Tyr Tyr  Asn Ala Ile Lys Asp  Thr Val Trp 
    1115                 1120                 1125             


Val Val  Cys Ser Thr Asn His  Glu Arg Tyr Lys Ile  Val Arg Asn 
    1130                 1135                 1140             


Lys Ala  Gly Tyr Tyr Glu Ser  His Pro Val Asp Val  Thr Lys Asn 
    1145                 1150                 1155             


Leu Lys  Asp Ile Phe Ser Gln  Ala Asn Ile Asn Tyr  Asn Glu Gly 
    1160                 1165                 1170             


Lys Asp  Ile Lys Pro Ile Ile  Ile Glu Ser Asn Asn  Ala Lys Leu 
    1175                 1180                 1185             


Leu Lys  Ser Ile Ala Glu Gln  Leu Lys Leu Ile Leu  Ala Met Arg 
    1190                 1195                 1200             


Tyr Asn  Asn Gly Lys His Gly  Asp Asp Glu Lys Asp  Tyr Ile Leu 
    1205                 1210                 1215             


Ser Pro  Val Lys Asn Lys Gln  Gly Lys Phe Phe Cys  Thr Leu Asp 
    1220                 1225                 1230             


Gly Asn  Gln Thr Leu Pro Ile  Asn Ala Asp Ala Asn  Gly Ala Tyr 
    1235                 1240                 1245             


Asn Ile  Ala Leu Lys Gly Leu  Leu Leu Ile Glu Lys  Ile Lys Lys 
    1250                 1255                 1260             


Gln Gln  Gly Lys Ile Lys Asp  Leu Tyr Ile Ser Asn  Leu Glu Trp 
    1265                 1270                 1275             


Phe Met  Phe Met Met Ser Arg  
    1280                 1285 


<210>  49
<211>  1367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  49

Met Glu Lys Ser Leu Asn Asp Phe Ile Gly Leu Tyr Ser Val Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Glu Leu Lys Pro Val Ser Glu Thr Leu Glu Asn Ile 
            20                  25                  30          


Lys Lys Phe His Phe Leu Glu Glu Asp Lys Lys Lys Ala Asn Asp Tyr 
        35                  40                  45              


Lys Asp Val Lys Lys Ile Ile Asp Asn Tyr His Lys Tyr Phe Ile Asp 
    50                  55                  60                  


Asp Val Leu Lys Asn Ala Ser Phe Asn Trp Lys Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Ile Arg Glu Tyr Asn Lys Asn Lys Ser Asp Asp Ser Ala Leu Val Ala 
                85                  90                  95      


Glu Gln Lys Lys Leu Gly Asp Ala Ile Leu Lys Leu Phe Thr Ser Asp 
            100                 105                 110         


Lys Arg Tyr Lys Ala Leu Thr Ala Ala Thr Pro Lys Glu Leu Phe Glu 
        115                 120                 125             


Ser Ile Leu Pro Asp Trp Phe Gly Glu Gln Cys Asn Gln Asp Leu Asn 
    130                 135                 140                 


Lys Ala Ala Leu Lys Thr Phe Gln Lys Phe Thr Ser Tyr Phe Thr Gly 
145                 150                 155                 160 


Phe Gln Glu Asn Arg Lys Asn Val Tyr Ser Ala Glu Ala Ile Pro Thr 
                165                 170                 175     


Ala Val Pro Tyr Arg Ile Val Asn Asp Asn Phe Pro Lys Phe Leu Gln 
            180                 185                 190         


Asn Val Leu Ile Phe Lys Thr Ile Gln Glu Lys Cys Pro Gln Ile Ile 
        195                 200                 205             


Asp Glu Val Glu Lys Glu Leu Ser Ser Tyr Leu Gly Lys Glu Lys Leu 
    210                 215                 220                 


Ala Gly Ile Phe Thr Leu Glu Ser Phe Asn Lys Tyr Leu Gly Gln Gly 
225                 230                 235                 240 


Gly Lys Glu Asn Gln Arg Gly Ile Asp Phe Tyr Asn Gln Ile Ile Gly 
                245                 250                 255     


Gly Val Val Glu Lys Glu Gly Gly Ile Asn Leu Arg Gly Val Asn Gln 
            260                 265                 270         


Phe Leu Asn Leu Tyr Trp Gln Gln His Pro Asp Phe Thr Lys Glu Asp 
        275                 280                 285             


Arg Arg Ile Lys Met Val Pro Leu Tyr Lys Gln Ile Leu Ser Asp Arg 
    290                 295                 300                 


Ser Ser Leu Ser Phe Lys Ile Glu Ser Ile Glu Asn Asp Glu Glu Leu 
305                 310                 315                 320 


Lys Asn Ala Leu Leu Glu Cys Ala Asp Lys Leu Glu Leu Lys Asn Asp 
                325                 330                 335     


Glu Lys Lys Ser Ile Phe Glu Glu Val Cys Asp Leu Phe Ser Ser Val 
            340                 345                 350         


Lys Asn Leu Asp Leu Ser Gly Ile Tyr Ile Asn Arg Lys Asp Ile Asn 
        355                 360                 365             


Ser Val Ser Arg Ile Leu Thr Gly Asp Trp Ser Trp Leu Gln Ser Arg 
    370                 375                 380                 


Met Asn Val Tyr Ala Glu Glu Lys Phe Thr Thr Lys Ala Glu Lys Ala 
385                 390                 395                 400 


Arg Trp Gln Lys Ser Leu Asp Asp Glu Gly Glu Asn Lys Ser Lys Gly 
                405                 410                 415     


Phe Tyr Ser Leu Thr Asp Leu Asn Glu Val Leu Glu Tyr Ser Ser Glu 
            420                 425                 430         


Asn Val Ala Glu Thr Asp Ile Arg Ile Thr Asp Tyr Phe Glu His Arg 
        435                 440                 445             


Cys Arg Tyr Tyr Val Asp Lys Glu Thr Glu Met Phe Val Gln Gly Ser 
    450                 455                 460                 


Glu Leu Val Ala Leu Ser Leu Gln Glu Met Cys Asp Asp Ile Leu Lys 
465                 470                 475                 480 


Lys Arg Lys Ala Met Asn Thr Val Leu Glu Asn Leu Ser Ser Glu Asn 
                485                 490                 495     


Lys Leu Arg Glu Lys Thr Asp Asp Val Ala Val Ile Lys Glu Tyr Leu 
            500                 505                 510         


Asp Ala Val Gln Glu Leu Leu His Arg Ile Lys Pro Leu Lys Val Asn 
        515                 520                 525             


Gly Val Gly Asp Ser Thr Phe Tyr Ser Val Tyr Asp Ser Ile Tyr Ser 
    530                 535                 540                 


Ala Leu Ser Glu Val Ile Ser Val Tyr Asn Lys Thr Arg Asn Tyr Ile 
545                 550                 555                 560 


Thr Lys Lys Ala Ala Ser Pro Glu Lys Tyr Lys Leu Asn Phe Asp Asn 
                565                 570                 575     


Pro Thr Leu Ala Asp Gly Trp Asp Leu Asn Lys Glu Gln Ala Asn Thr 
            580                 585                 590         


Ser Val Ile Leu Arg Lys Asp Gly Met Phe Tyr Leu Gly Ile Met Asn 
        595                 600                 605             


Pro Lys Asn Lys Pro Lys Phe Ala Glu Lys Tyr Asp Cys Gly Asn Glu 
    610                 615                 620                 


Ser Cys Tyr Glu Lys Met Ile Tyr Lys Gln Phe Asp Ala Thr Lys Gln 
625                 630                 635                 640 


Ile Pro Lys Cys Ser Thr Gln Lys Lys Glu Val Gln Lys Tyr Phe Leu 
                645                 650                 655     


Ser Gly Ala Thr Glu Pro Tyr Ile Leu Asn Asp Lys Lys Ser Phe Lys 
            660                 665                 670         


Ser Glu Leu Ile Ile Thr Lys Asp Ile Trp Phe Met Asn Asn His Val 
        675                 680                 685             


Trp Asp Gly Glu Lys Phe Val Pro Lys Arg Asp Asn Glu Thr Arg Pro 
    690                 695                 700                 


Lys Lys Phe Gln Ile Gly Tyr Phe Lys Gln Thr Gly Asp Phe Asp Gly 
705                 710                 715                 720 


Tyr Lys Asn Ala Leu Ser Asn Trp Ile Ser Phe Cys Lys Asn Phe Leu 
                725                 730                 735     


Gln Ser Tyr Leu Ser Ala Thr Val Tyr Asp Tyr Asn Phe Lys Asn Ser 
            740                 745                 750         


Glu Glu Tyr Glu Gly Leu Asp Glu Phe Tyr Asn Tyr Leu Asn Ala Thr 
        755                 760                 765             


Cys Tyr Lys Leu Asn Phe Ile Asn Ile Pro Glu Thr Glu Ile Asn Lys 
    770                 775                 780                 


Met Val Ser Glu Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp 
785                 790                 795                 800 


Phe Ala Ser Gly Ser Thr Gly Met Pro Asn Met His Thr Leu Tyr Trp 
                805                 810                 815     


Lys Asn Leu Phe Ser Asp Glu Asn Leu Lys Asn Val Cys Leu Lys Leu 
            820                 825                 830         


Asn Gly Glu Ala Glu Leu Phe Tyr Arg Pro Ala Gly Ile Lys Glu Pro 
        835                 840                 845             


Val Ile His Lys Glu Gly Ser Tyr Leu Val Asn Arg Thr Thr Glu Asp 
    850                 855                 860                 


Gly Glu Ser Ile Pro Glu Lys Ile Tyr Phe Glu Ile Tyr Lys Asn Ala 
865                 870                 875                 880 


Asn Gly Lys Leu Glu Lys Leu Ser Asp Glu Ala Gln Asn Tyr Ile Ser 
                885                 890                 895     


Asn His Glu Val Val Ile Lys Lys Ala Gly His Glu Ile Ile Lys Asp 
            900                 905                 910         


Arg His Tyr Thr Glu Pro Lys Phe Leu Phe His Val Pro Leu Thr Ile 
        915                 920                 925             


Asn Phe Lys Ala Ser Gly Asn Ser Tyr Ser Ile Asn Glu Asn Val Arg 
    930                 935                 940                 


Lys Phe Leu Lys Asn Asn Pro Asp Val Asn Ile Ile Gly Leu Asp Arg 
945                 950                 955                 960 


Gly Glu Arg His Leu Ile Tyr Leu Ser Leu Ile Asn Gln Lys Gly Glu 
                965                 970                 975     


Ile Ile Lys Gln Phe Thr Phe Asn Glu Val Glu Arg Asn Lys Asn Gly 
            980                 985                 990         


Arg Thr Ile Lys Val Asn Tyr His  Glu Lys Leu Asp Gln  Arg Glu Lys 
        995                 1000                 1005             


Glu Arg  Asp Ala Ala Arg Lys  Ser Trp Gln Ala Ile  Gly Lys Ile 
    1010                 1015                 1020             


Ala Glu  Leu Lys Glu Gly Tyr  Leu Ser Ala Val Ile  His Gln Leu 
    1025                 1030                 1035             


Thr Lys  Leu Met Val Glu Tyr  Asn Ala Val Val Val  Met Glu Asp 
    1040                 1045                 1050             


Leu Asn  Phe Gly Phe Lys Arg  Gly Arg Phe His Val  Glu Lys Gln 
    1055                 1060                 1065             


Val Tyr  Gln Lys Phe Glu His  Ile Leu Ile Asp Lys  Ser Asn Tyr 
    1070                 1075                 1080             


Leu Val  Phe Lys Asp Arg Gly  Leu Asn Glu Pro Gly  Gly Val Leu 
    1085                 1090                 1095             


Asn Gly  Tyr Gln Ile Ala Gly  Gln Phe Glu Ser Phe  Gln Lys Leu 
    1100                 1105                 1110             


Gly Lys  Gln Ser Gly Met Leu  Phe Tyr Val Pro Ala  Gly Tyr Thr 
    1115                 1120                 1125             


Ser Lys  Ile Asp Pro Lys Thr  Gly Phe Val Ser Met  Met Asn Phe 
    1130                 1135                 1140             


Lys Asp  Leu Thr Asn Val His  Lys Lys Arg Asp Phe  Phe Ser Lys 
    1145                 1150                 1155             


Phe Asp  Asn Ile His Tyr Asp  Glu Ala Asn Gly Ser  Phe Val Phe 
    1160                 1165                 1170             


Thr Phe  Asp Tyr Lys Lys Phe  Asp Gly Lys Ala Lys  Glu Glu Met 
    1175                 1180                 1185             


Lys Leu  Thr Lys Trp Ser Val  Tyr Ser Arg Asp Lys  Arg Ile Val 
    1190                 1195                 1200             


Tyr Phe  Ala Lys Thr Lys Ser  Tyr Glu Asp Val Leu  Pro Thr Glu 
    1205                 1210                 1215             


Lys Leu  Gln Lys Ile Phe Glu  Ser Asn Gly Ile Asp  Tyr Lys Ser 
    1220                 1225                 1230             


Gly Asn  Asn Ile Gln Asp Ser  Val Met Ala Ile Gly  Ala Asp Leu 
    1235                 1240                 1245             


Lys Glu  Gly Ala Lys Pro Ser  Lys Glu Ile Ser Asp  Phe Trp Asp 
    1250                 1255                 1260             


Gly Leu  Leu Ser Asn Phe Lys  Leu Ile Leu Gln Met  Arg Asn Ser 
    1265                 1270                 1275             


Asn Ala  Arg Thr Gly Glu Asp  Tyr Ile Ile Ser Pro  Val Met Ala 
    1280                 1285                 1290             


Asp Asp  Gly Thr Phe Phe Asp  Ser Arg Glu Glu Phe  Lys Lys Gly 
    1295                 1300                 1305             


Glu Asp  Ala Lys Leu Pro Leu  Asp Ala Asp Ala Asn  Gly Ala Tyr 
    1310                 1315                 1320             


His Ile  Ala Leu Lys Gly Leu  Ser Leu Ile Asn Lys  Ile Asn Leu 
    1325                 1330                 1335             


Ser Lys  Asp Glu Glu Leu Lys  Lys Phe Asp Met Lys  Ile Ser Asn 
    1340                 1345                 1350             


Ala Asp  Trp Phe Lys Phe Ala  Gln Glu Lys Asn Tyr  Ala Lys 
    1355                 1360                 1365         


<210>  50
<211>  1366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  50

Met Asn Thr Gln Lys Lys Glu Phe Asn Pro Lys Ser Phe Lys Asp Phe 
1               5                   10                  15      


Thr Asn Leu Tyr Ser Leu Asn Lys Thr Leu Arg Phe Ser Leu Thr Pro 
            20                  25                  30          


Asn Lys Lys Thr Ala Glu Ile Leu Glu Phe Asn Lys Gln Lys Glu Val 
        35                  40                  45              


Lys Cys Phe Ser Asn Asp Arg Lys Ile Ala Gly Ala Tyr Gln Glu Ile 
    50                  55                  60                  


Lys Lys Tyr Leu Asn Lys Leu His Gln Glu Phe Ile Gln Glu Ala Met 
65                  70                  75                  80  


Lys Phe Phe Ala Phe Ser Glu Glu Glu Leu Lys Gly Phe Glu Lys Glu 
                85                  90                  95      


Tyr Leu Asn Leu Leu Asn Phe Thr Asp Lys Asp Asn Phe Lys Lys Lys 
            100                 105                 110         


Asn Lys Ile Arg Asn Glu Tyr Glu Gln Glu Arg Lys Ile Leu Thr Ile 
        115                 120                 125             


Lys Ile Ala Thr Tyr Phe Ser Lys Phe Lys Ser Glu Lys Tyr Gln Ser 
    130                 135                 140                 


Phe Asn Leu Ala Asn Ile Thr Gly Lys Lys Val Phe Ser Ile Leu Glu 
145                 150                 155                 160 


Gln Lys Tyr Lys Glu Asp Lys Lys Thr Leu Lys Ile Ile His Ile Phe 
                165                 170                 175     


Lys Tyr Lys Pro Thr Lys Asp Glu Lys Lys Glu Gly Glu Ala Val Asn 
            180                 185                 190         


Phe Ser Thr Tyr Leu Thr Gly Phe Asn Glu Asn Arg Lys Asn Phe Tyr 
        195                 200                 205             


Lys Ser Glu Asp Lys Ala Gly Gln Phe Ala Thr Arg Thr Ile Asp Asn 
    210                 215                 220                 


Leu Ala Gln Phe Ile Lys Asn Lys Lys Leu Phe Glu Asp Lys Tyr Gln 
225                 230                 235                 240 


Lys Asn Tyr Ser Lys Ile Gly Ile Leu Asp Glu Gln Ile Lys Ile Phe 
                245                 250                 255     


Asn Leu Asp Tyr Phe Asn Asn Leu Phe Leu Gln Glu Gly Leu Asp Glu 
            260                 265                 270         


Tyr Asn Gly Ile Leu Gly Asn Asn Lys Gly Glu Glu Asn Lys Ser Asn 
        275                 280                 285             


Glu Gly Ile Asn Gln Lys Ile Asn Ile Phe Lys Gln Lys Glu Lys Ala 
    290                 295                 300                 


Arg Leu Lys Lys Glu Lys Glu Asn Phe Asn Lys Ser Asp Phe Pro Leu 
305                 310                 315                 320 


Phe Lys Glu Leu Tyr Lys Gln Ile Gly Ser Ile Arg Lys Glu Asn Asp 
                325                 330                 335     


Val Tyr Val Glu Ile Lys Thr Asp Lys Glu Leu Val Glu Glu Leu Asn 
            340                 345                 350         


Asn Phe Pro Lys Asn Val Glu Asn Tyr Leu Lys Asp Ile Gln Ser Phe 
        355                 360                 365             


Tyr Lys Thr Phe Phe Glu Lys Leu Gln Asn Glu Glu Tyr Glu Leu Asp 
    370                 375                 380                 


Lys Ile Tyr Leu Pro Lys Ser Val Gly Thr Tyr Phe Ser Tyr Ile Ala 
385                 390                 395                 400 


Phe Ser Asp Trp Asn Lys Leu Ala Phe Ile Tyr Asn Lys Arg Tyr Lys 
                405                 410                 415     


Asn Glu Lys Ile Lys Ile Val Glu Gly Gly Asp Val Asn Val Gln Tyr 
            420                 425                 430         


Arg Ser Leu Glu Val Leu Lys Asn Arg Ile Asp Glu Leu Lys Asp Glu 
        435                 440                 445             


Asp Asn Leu Asn Phe Asn Lys Phe Phe Ile Asp Lys Leu Lys Phe Asn 
    450                 455                 460                 


Glu Ala Lys Lys Glu Asn Asn Trp Gln Asn Phe Trp Phe Cys Ile Glu 
465                 470                 475                 480 


Tyr Tyr Ile Asn Ser Gln Phe Ile Gly Gly Glu Lys Asn Ile Leu Asn 
                485                 490                 495     


Lys Glu Lys Asn Glu Tyr Glu Ile Leu Pro Phe Gly Ser Leu Lys Glu 
            500                 505                 510         


Leu Lys Glu Lys Tyr Phe Glu Ala Val Lys Lys Tyr Lys Glu Lys Met 
        515                 520                 525             


Val Asp Thr Glu Ser Gly Leu Thr Asp Asp Glu Glu Lys Glu Ile Lys 
    530                 535                 540                 


Glu Thr Leu Lys Asn Tyr Leu Asp Arg Ile Lys Glu Ile Glu Arg Ile 
545                 550                 555                 560 


Ala Lys Tyr Phe Asp Leu Lys Lys Ser Phe Glu Glu Ile Lys Gln Glu 
                565                 570                 575     


Asp Leu Asp Ser Asn Phe Tyr Gly Glu Tyr Gln Lys Val Val Asp Lys 
            580                 585                 590         


Thr Asn Glu Leu Lys Ile Tyr Gln Tyr Tyr Ser Glu Phe Arg Asn Tyr 
        595                 600                 605             


Leu Thr Gln Asn Asn Ser Val Glu Glu Lys Ile Lys Leu Asn Phe Asn 
    610                 615                 620                 


Ser Gly Leu Leu Leu Asp Gly Trp Asp Leu Asn Lys Glu Lys Val Lys 
625                 630                 635                 640 


Phe Ser Ile Ile Phe Gln Glu Asn Gly Lys Tyr Tyr Leu Gly Ile Ile 
                645                 650                 655     


Asn Lys Glu Lys Asp Lys Thr Ile Leu Asp Lys Asp Lys His Pro Glu 
            660                 665                 670         


Ile Phe Thr Lys Asn Ser Asp Phe Arg Lys Met Glu Tyr Lys Leu Phe 
        675                 680                 685             


Pro Ser Pro Ser Lys Met Leu Pro Lys Ile Ser Phe Ser Glu Thr Ala 
    690                 695                 700                 


Lys Lys Gly Asp Glu Asp Val Gly Trp Ser Glu Glu Ile Gln Lys Ile 
705                 710                 715                 720 


Lys Asp Glu Phe Ala Glu Phe Gln Glu Tyr Lys Lys Lys Ser Lys Asp 
                725                 730                 735     


Asn Trp Lys Asp Glu Phe Asn Arg Gly Lys Leu Asn Lys Leu Ile Asp 
            740                 745                 750         


Tyr Tyr Lys Gln Val Leu Glu Lys His Ser Glu Gly Tyr Met Asn Thr 
        755                 760                 765             


Tyr Asn Phe Glu Leu Lys Asp Ser Ser Lys Tyr Lys Asn Leu Gly Glu 
    770                 775                 780                 


Phe Asn Asp Asp Ile Ala Arg Gln Asn Tyr Lys Val Lys Phe Val Gly 
785                 790                 795                 800 


Ile Asp Lys Asn Tyr Ile Asp Glu Lys Val Ala Asn Gly Glu Leu Phe 
                805                 810                 815     


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Glu Asp Lys Lys Glu Gly 
            820                 825                 830         


Ser Thr Asn Asn Leu Glu Thr Ile Tyr Phe Lys Glu Leu Phe Ser Lys 
        835                 840                 845             


Glu Asn Leu Glu Asn Pro Val Phe Lys Leu Ser Gly Gly Ala Glu Met 
    850                 855                 860                 


Phe Phe Arg Asn Lys Ile Glu Lys Lys Lys Glu Lys Lys Lys Leu Asp 
865                 870                 875                 880 


Lys Asp Gly Lys Pro Met Ile Ser Lys Lys Gly Glu Lys Val Val Asp 
                885                 890                 895     


Lys Arg Arg Phe Ser Glu Asn Lys Ile Leu Phe His Leu Pro Ile Glu 
            900                 905                 910         


Ile Asn Tyr Gly Lys Gly Lys Met Pro Asn Phe Asn Lys Lys Ile Asn 
        915                 920                 925             


Glu Tyr Ile Ser Lys Asn Pro Glu Asn Ile Lys Ile Ile Gly Ile Asp 
    930                 935                 940                 


Arg Gly Glu Lys His Leu Leu Tyr Tyr Ser Ile Ile Asp Gln Asn Gly 
945                 950                 955                 960 


Asn Asn Ile Glu Ser Met Ser Leu Asn Ala Val Asp Glu Phe Gly Asn 
                965                 970                 975     


Phe Val Asn Pro Glu Lys Leu Glu Glu Tyr Glu Ile Asp Asn Asn Gly 
            980                 985                 990         


Lys Lys Glu Arg Arg Trp Lys Tyr  Ile Val Asn Asp Lys  Glu Ile Lys 
        995                 1000                 1005             


Val Thr  Asn Tyr Gln Arg Lys  Leu Asp Glu Leu Glu  Lys Glu Arg 
    1010                 1015                 1020             


Gln Lys  Ser Arg Gln Ser Trp  Gln Asn Ile Asn Lys  Ile Lys Asn 
    1025                 1030                 1035             


Leu Lys  Lys Gly Tyr Ile Ser  Phe Val Val Lys Lys  Ile Val Asp 
    1040                 1045                 1050             


Leu Ala  Ile Glu Asn Asn Ala  Ile Ile Ile Leu Glu  Asp Leu Asn 
    1055                 1060                 1065             


Phe Gly  Phe Lys Ser Phe Arg  Gln Lys Ile Glu Lys  Asn Val Tyr 
    1070                 1075                 1080             


Gln Gln  Phe Glu Lys Ala Leu  Ile Asp Lys Leu Gly  Phe Val Val 
    1085                 1090                 1095             


Asp Lys  Gln Lys Gln Asn Gln  Arg Phe Ala Pro Gln  Leu Ser Ala 
    1100                 1105                 1110             


Pro Phe  Glu Ser Phe Gln Lys  Ile Gly Lys Gln Thr  Gly Ile Val 
    1115                 1120                 1125             


Tyr Tyr  Val Leu Ala Asn Asn  Thr Ser Lys Val Cys  Pro Ser Cys 
    1130                 1135                 1140             


Gln Trp  Ile Lys Asn Phe Tyr  Leu Lys Tyr Glu Lys  Lys Asn Thr 
    1145                 1150                 1155             


Ile Phe  Asn Leu Gln Lys Asn  Gln Lys Leu Lys Val  Phe Phe Glu 
    1160                 1165                 1170             


Gln Glu  Lys Asn Arg Phe Arg  Phe Glu Tyr Gln Met  Ser Lys Glu 
    1175                 1180                 1185             


Tyr Ile  Ser Val Tyr Ser Asp  Val Asp Arg Gln Arg  Tyr Asp Lys 
    1190                 1195                 1200             


Thr Lys  Asn Gln Asn Lys Gly  Gly Tyr Leu Glu Tyr  Lys Asn Ser 
    1205                 1210                 1215             


Asn Gln  Lys Glu Ile Ile Asp  Lys Asp Gly Val Ile  Gln Lys Gln 
    1220                 1225                 1230             


Ser Ile  Thr Leu Gln Leu Lys  Glu Leu Phe Lys Glu  Asn His Ile 
    1235                 1240                 1245             


Asp Leu  Glu Lys Glu Ile Leu  Lys Gln Leu Asp Asn  Lys Lys Glu 
    1250                 1255                 1260             


Lys Asn  Ser Gly Tyr Thr Gly  Val Tyr Asn Lys Phe  Ile Tyr Leu 
    1265                 1270                 1275             


Phe Asn  Leu Ile Leu Gln Ile  Arg Asn Ala Ile Ser  Phe Arg Glu 
    1280                 1285                 1290             


Lys Asp  Tyr Ile Gln Cys Pro  Ser Cys His Phe Asp  Thr Arg Lys 
    1295                 1300                 1305             


Glu Asn  Tyr Leu Lys Ile Asn  Asp Gly Asp Gly Asn  Gly Ala Tyr 
    1310                 1315                 1320             


Asn Ile  Ala Leu Arg Gly Leu  Tyr Leu Leu Lys Gly  Lys Asn Gly 
    1325                 1330                 1335             


Ile Ile  Asn Asn Leu Glu Lys  Ile Lys Leu Ile Phe  Ser Asn Asn 
    1340                 1345                 1350             


Asp Tyr  Phe Gln Trp Ala Lys  Lys Leu Lys Asn Lys  Lys 
    1355                 1360                 1365     


<210>  51
<211>  1275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  51

Met Gln Asn Lys Gln Ser Phe Ala Asp Phe Thr Asn Leu Tyr Ser Leu 
1               5                   10                  15      


Ser Lys Thr Leu Arg Phe Glu Leu Lys Pro Ile Gly Gln Thr Gln Ala 
            20                  25                  30          


Met Leu Asp Glu Asn Lys Ile Phe Glu Val Asp Glu Asn Arg Lys Lys 
        35                  40                  45              


Ala Tyr Asp Lys Thr Lys Pro Tyr Phe Asp Arg Leu His Arg Glu Phe 
    50                  55                  60                  


Ile Asn Glu Ser Leu Ser Asn Ala Gln Leu Lys Gly Ile Ser Glu Tyr 
65                  70                  75                  80  


Phe Glu Thr Phe Lys Gln Phe Arg Ser Asn Gln Asn Asn Lys Asp Leu 
                85                  90                  95      


Lys Glu Leu Ile Asn Lys Gln Gln Lys Phe Leu Arg His Gln Ile Val 
            100                 105                 110         


Thr Leu Phe Asp Glu Asn Gly Lys His Trp Ala Thr Thr Lys Tyr Ala 
        115                 120                 125             


His Leu Lys Ile Lys Lys Lys Asn Leu Asp Ile Leu Phe Asp Glu Gln 
    130                 135                 140                 


Val Phe Tyr Ile Leu Lys Glu Arg Tyr Gly Ser Glu Lys Glu Thr Gln 
145                 150                 155                 160 


Leu Val Asp Lys Glu Thr Gly Ala Val Thr Ser Ile Phe Asp Asn Trp 
                165                 170                 175     


Lys Gly Phe Thr Gly Tyr Phe Thr Lys Phe Phe Glu Thr Arg Lys Asn 
            180                 185                 190         


Phe Tyr Lys Ser Asp Gly Thr Ser Thr Ala Leu Ala Thr Arg Ile Ile 
        195                 200                 205             


Asp Gln Asn Leu Asn Arg Phe Phe Asp Asn Leu Glu Thr Phe His Lys 
    210                 215                 220                 


Ile Lys Asp Lys Ile Asp Val Lys Glu Val Glu Ile Phe Phe Lys Leu 
225                 230                 235                 240 


Lys Ala Asp Asn Val Phe Ser Ile Asp Phe Tyr Asn Gln Cys Leu Leu 
                245                 250                 255     


Gln Asn Gly Ile Asp Lys Tyr Asn Asp Phe Leu Gly Gly Gln Thr Leu 
            260                 265                 270         


Glu Asn Gly Glu Lys Gln Lys Gly Ile Asn Glu Ile Ile Asn Lys Tyr 
        275                 280                 285             


Arg Gln Asp Asn Lys Asp Gln Lys Leu Pro Phe Leu Lys Lys Leu Asp 
    290                 295                 300                 


Lys Gln Ile Leu Ser Glu Lys Asp Arg Phe Ile Asn Glu Ile Glu Ser 
305                 310                 315                 320 


Lys Glu Glu Phe Phe Gln Val Leu Thr Glu Phe Tyr Gln Ser Ala Thr 
                325                 330                 335     


Val Lys Val Thr Ile Ile Lys Thr Leu Leu Asn Asp Phe Val His Asn 
            340                 345                 350         


Thr Asp Lys Tyr Lys Leu Glu Lys Ile Tyr Leu Thr Lys Glu Ala Phe 
        355                 360                 365             


Asn Thr Ile Ala Asn Lys Trp Thr Asp Glu Thr Gln Ile Phe Glu Asp 
    370                 375                 380                 


Asn Leu Asp Leu Val Leu Lys Asn Lys Lys Ile Thr Ala Lys Gln Asp 
385                 390                 395                 400 


Phe Ile Pro Leu Ala Tyr Ile Lys Glu Ala Leu Glu Val Ile Glu Lys 
                405                 410                 415     


Asp Arg Lys Phe Phe Lys Asp Arg Tyr Tyr Asn Asp Pro Gln Ile Gly 
            420                 425                 430         


Phe Phe Pro Asp Gln Ser Tyr Trp Glu Gln Phe Leu Ala Ile Leu Asn 
        435                 440                 445             


Phe Glu Phe Met Thr His Phe Gln Arg Val Ala Lys Asp Lys Ile Thr 
    450                 455                 460                 


Gly Lys Lys Ile Glu Leu Gly Tyr Phe Val Phe Glu Lys Arg Ile Lys 
465                 470                 475                 480 


Glu Leu Leu Asp Ser Asp Pro Ser Leu Asn Ser Gln Ser Lys Ile Ile 
                485                 490                 495     


Ile Lys Glu Phe Ala Asp Glu Val Leu His Ile Phe Gln Met Ala Lys 
            500                 505                 510         


Tyr Phe Ala Leu Glu Lys Lys Arg Glu Trp Lys Gly Asp Tyr Tyr Gln 
        515                 520                 525             


Leu Asp Asp Gln Phe Tyr Asn His Ile Asp Tyr Gly Phe Lys Asp Gln 
    530                 535                 540                 


Phe Tyr Glu Asn Ala Tyr Glu Lys Ile Val Gln Pro Tyr Asn Lys Ile 
545                 550                 555                 560 


Arg Asn Tyr Leu Thr Lys Lys Pro Tyr Ser Asp Val Lys Trp Lys Leu 
                565                 570                 575     


Asn Phe Gly Asn Pro Thr Leu Ala Asn Gly Trp Asp Lys Asn Lys Glu 
            580                 585                 590         


Ala Asp Asn Thr Ala Val Ile Leu Lys Lys Asp Gly Asn Tyr Tyr Leu 
        595                 600                 605             


Gly Val Met Lys Lys Gly Lys Asn Lys Ile Phe Ser Asp Gln Asn Lys 
    610                 615                 620                 


Glu Lys Tyr Lys Ala Tyr Asn Ser Ala Tyr Tyr Glu Lys Leu Val Tyr 
625                 630                 635                 640 


Lys Leu Phe Pro Asp Pro Ser Lys Met Phe Pro Lys Val Cys Phe Ser 
                645                 650                 655     


Lys Lys Gly Leu Asn Phe Phe Gln Pro Ser Glu Glu Ile Leu Arg Ile 
            660                 665                 670         


Tyr Lys Asn Asn Glu Phe Lys Lys Gly Asn Thr Phe Ser Ile Ser Ser 
        675                 680                 685             


Met Gln Lys Leu Ile Ala Phe Tyr Ile Asp Cys Leu Gly Leu Tyr Glu 
    690                 695                 700                 


Gly Trp Lys His Tyr Glu Phe Lys Asn Ile Lys Asp Val Arg Gln Tyr 
705                 710                 715                 720 


Lys Glu Asn Ile Gly Glu Phe Tyr Ala Asp Val Ala Glu Ser Gly Tyr 
                725                 730                 735     


Lys Leu Trp Phe Glu Lys Ile Ser Glu Glu Tyr Ile Thr Gln Lys Asn 
            740                 745                 750         


Gln Leu Gly Glu Leu Phe Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala 
        755                 760                 765             


Lys Lys Thr Thr Gly Arg Lys Asn Leu His Thr Ile Tyr Phe Glu Glu 
    770                 775                 780                 


Leu Phe Ser Gln Thr Asn Ile Asp Asn Asn Phe Pro Phe Lys Leu Asn 
785                 790                 795                 800 


Gly Gln Ala Glu Leu Phe Tyr Arg Pro Lys Ser Leu Glu Lys Ile Glu 
                805                 810                 815     


Glu Lys Arg Asn Phe Lys Arg Ser Ile Val Asn Lys Lys Arg Tyr Thr 
            820                 825                 830         


Gln Asn Lys Ile Phe Phe His Val Pro Ile Thr Leu Asn Arg Thr Ser 
        835                 840                 845             


Glu Asn Ile Gly Arg Phe Asn Val Arg Val Asn Asn Phe Leu Ala Asn 
    850                 855                 860                 


Asn Ser Asn Val Asn Ile Val Gly Val Asp Arg Gly Glu Lys Asn Leu 
865                 870                 875                 880 


Ala Tyr Tyr Ser Ile Ile Lys Gln Asn Gly Glu Val Leu Lys Ser Gly 
                885                 890                 895     


Ser Leu Asn Ile Ile Asn Gly Val Asp Tyr His Ala Leu Leu Thr Asp 
            900                 905                 910         


Arg Ala Gln Arg Arg Glu Gln Glu Arg Arg Asn Trp Gln Asp Val Glu 
        915                 920                 925             


Ser Ile Lys Asp Leu Lys Arg Gly Tyr Ile Ser Gln Val Val His Glu 
    930                 935                 940                 


Leu Val Ser Leu Ala Ile Lys Tyr Asn Ala Ile Ile Val Met Glu Asp 
945                 950                 955                 960 


Leu Asn Met Arg Phe Lys Gln Ile Arg Gly Gly Ile Glu Lys Ser Thr 
                965                 970                 975     


Tyr Gln Gln Leu Glu Lys Ala Leu Ile Glu Lys Leu Asn Phe Leu Val 
            980                 985                 990         


Asn Lys Glu Glu Thr Asp Ser Asn  Gln Ala Gly Asn Leu  Leu Asn Ala 
        995                 1000                 1005             


Tyr Gln  Leu Thr Ala Pro Phe  Lys Thr Phe Lys Asp  Met Gly Lys 
    1010                 1015                 1020             


Gln Thr  Gly Ile Ile Phe Tyr  Thr Gln Ala Ser Tyr  Thr Ser Lys 
    1025                 1030                 1035             


Ile Asp  Pro Leu Thr Gly Trp  Arg Pro Asn Ile Tyr  Leu Arg Tyr 
    1040                 1045                 1050             


Ser Asn  Ala Lys Gln Ala Lys  Ala Asp Ile Leu Met  Phe Thr Asn 
    1055                 1060                 1065             


Ile Tyr  Phe Ser Glu Lys Lys  Asp Arg Phe Glu Phe  Thr Tyr Asp 
    1070                 1075                 1080             


Leu Glu  Lys Ile Asp Asp Lys  Arg Lys Asp Leu Pro  Ile Lys Thr 
    1085                 1090                 1095             


Glu Trp  Thr Val Cys Ser Asn  Val Glu Arg Phe Ser  Trp Glu Lys 
    1100                 1105                 1110             


Ser Leu  Asn Asn Asn Lys Gly  Gly Tyr Val His Tyr  Pro Ile Gln 
    1115                 1120                 1125             


Asp Ser  Asn Gly Glu Glu Ser  Ile Thr Ser Lys Leu  Lys Lys Leu 
    1130                 1135                 1140             


Phe Met  Asp Phe Gly Ile Asp  Leu Thr Asp Ile Lys  Thr Gln Ile 
    1145                 1150                 1155             


Glu Ser  Leu Asp Thr Asn Lys  Lys Asp Asn Ala Asn  Phe Phe Arg 
    1160                 1165                 1170             


Lys Phe  Ile Phe Tyr Phe Gln  Leu Ile Cys Gln Ile  Arg Asn Thr 
    1175                 1180                 1185             


Gln Val  Asn Lys Ser Asp Asp  Gly Asn Asp Phe Ile  Phe Ser Pro 
    1190                 1195                 1200             


Val Glu  Pro Phe Phe Asp Ser  Arg Phe Ala Asp Lys  Phe Arg Lys 
    1205                 1210                 1215             


Asn Leu  Pro Lys Asn Gly Asp  Glu Asn Gly Ala Tyr  Asn Ile Ala 
    1220                 1225                 1230             


Arg Lys  Gly Leu Ile Ile Leu  His Lys Ile Ser Asp  Tyr Phe Val 
    1235                 1240                 1245             


Lys Glu  Gly Ser Thr Asp Lys  Ile Ser Trp Lys Asp  Leu Ser Ile 
    1250                 1255                 1260             


Ser Gln  Thr Glu Trp Asp Asn  Phe Thr Thr Asp Lys  
    1265                 1270                 1275 


<210>  52
<211>  1368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  52

Met Lys Lys Glu Lys Glu Phe Lys Ser Phe Gly Asp Phe Thr Asn Leu 
1               5                   10                  15      


Tyr Glu Ile Ser Lys Thr Leu Arg Phe Glu Leu Lys Pro Val Glu Asn 
            20                  25                  30          


Thr Gln Thr Met Leu Asp Glu Ala Asp Val Phe Gly Lys Asp Lys Val 
        35                  40                  45              


Ile Lys Asp Lys Tyr Thr Lys Thr Lys Pro Phe Ile Asp Lys Leu His 
    50                  55                  60                  


Arg Glu Phe Val Asp Glu Ser Leu Lys Asp Val Ser Leu Ser Gly Leu 
65                  70                  75                  80  


Lys Lys Tyr Ser Glu Val Leu Glu Asn Trp Lys Lys Asn Lys Lys Asp 
                85                  90                  95      


Lys Asp Ile Val Lys Glu Leu Lys Lys Glu Glu Glu Arg Leu Arg Lys 
            100                 105                 110         


Glu Val Val Glu Phe Phe Asp Asn Thr Ala Lys Lys Trp Ala Asn Glu 
        115                 120                 125             


Lys Tyr Lys Glu Leu Gly Leu Lys Lys Lys Asp Ile Gly Ile Leu Phe 
    130                 135                 140                 


Glu Glu Ser Val Phe Asp Leu Leu Lys Glu Lys Tyr Gly Glu Glu Gln 
145                 150                 155                 160 


Asp Ser Phe Leu Lys Glu Glu Lys Gly Asp Phe Leu Lys Asn Glu Lys 
                165                 170                 175     


Gly Glu Lys Val Ser Ile Phe Asp Glu Trp Lys Gly Phe Val Gly Tyr 
            180                 185                 190         


Phe Thr Lys Phe Gln Glu Thr Arg Lys Asn Phe Tyr Lys Asn Asp Gly 
        195                 200                 205             


Thr Glu Thr Ala Leu Ala Thr Arg Ile Ile Asp Gln Asn Leu Lys Arg 
    210                 215                 220                 


Phe Cys Asp Asn Ile Asp Asp Phe Lys Lys Ile Lys Asn Lys Ile Asp 
225                 230                 235                 240 


Phe Ser Glu Val Glu Lys Asn Phe Asn Lys Thr Ala Asp Val Phe Ser 
                245                 250                 255     


Leu Asp Phe Tyr Asn Gln Cys Leu Leu Gln Lys Gly Ile Asp Ser Tyr 
            260                 265                 270         


Asn Glu Phe Ile Gly Gly Lys Thr Leu Glu Asn Gly Lys Lys Leu Lys 
        275                 280                 285             


Gly Val Asn Glu Leu Val Asn Glu Tyr Arg Gln Lys Asn Lys Asn Glu 
    290                 295                 300                 


Lys Val Ser Phe Leu Lys Leu Leu Asp Lys Gln Ile Leu Ser Glu Lys 
305                 310                 315                 320 


Glu Lys Leu Ser Phe Gly Ile Glu Asn Asp Glu Gln Leu Leu Val Val 
                325                 330                 335     


Leu Asn Ser Phe Tyr Glu Thr Ala Glu Glu Lys Thr Lys Ile Leu Arg 
            340                 345                 350         


Thr Leu Phe Gly Asp Phe Val Glu His Asn Glu Asn Tyr Asp Leu Asp 
        355                 360                 365             


Lys Thr Tyr Ile Ser Lys Val Ala Phe Asn Thr Ile Ser His Lys Trp 
    370                 375                 380                 


Thr Asn Glu Thr His Lys Phe Glu Glu Leu Leu Tyr Gly Ala Met Lys 
385                 390                 395                 400 


Glu Asp Lys Pro Ile Gly Leu Asn Tyr Asp Lys Lys Glu Asp Ser Tyr 
                405                 410                 415     


Lys Phe Pro Asp Phe Ile Ala Leu Gly Tyr Leu Lys Lys Cys Leu Asn 
            420                 425                 430         


Asn Leu Asp Cys Asp Thr Lys Phe Trp Lys Glu Lys Tyr Tyr Glu Asn 
        435                 440                 445             


Asn Ala Asp Lys Lys Asp Lys Asp Lys Gly Phe Leu Thr Gly Gly Gln 
    450                 455                 460                 


Asn Ala Trp Asp Gln Phe Leu Gln Ile Phe Ile Phe Glu Phe Asn Gln 
465                 470                 475                 480 


Leu Phe Asn Ser Glu Ala Phe Asp Asn Lys Gly Lys Glu Ile Lys Ile 
                485                 490                 495     


Gly Tyr Asp Asn Phe Arg Lys Asp Phe Glu Glu Ile Ile Asn Gln Lys 
            500                 505                 510         


Asp Phe Lys Asn Asp Glu Asn Leu Lys Ile Ala Ile Lys Asn Phe Ala 
        515                 520                 525             


Asp Ser Val Leu Trp Ile Tyr Gln Met Ala Lys Tyr Phe Ala Ile Glu 
    530                 535                 540                 


Lys Lys Arg Gly Trp Asp Asp Asp Phe Glu Leu Ser Glu Phe Tyr Thr 
545                 550                 555                 560 


Asn Pro Ser Asn Gly Tyr Ser Leu Phe Tyr Asp Arg Ala Tyr Glu Glu 
                565                 570                 575     


Ile Val Gln Lys Tyr Asn Asp Leu Arg Asn Tyr Leu Thr Lys Lys Pro 
            580                 585                 590         


Tyr Lys Glu Asp Lys Trp Lys Leu Asn Phe Glu Asn Pro Thr Leu Ala 
        595                 600                 605             


Asn Gly Phe Asp Lys Asn Lys Glu Ser Asp Asn Ser Thr Val Ile Leu 
    610                 615                 620                 


Arg Lys Lys Arg Lys Tyr Tyr Leu Gly Leu Met Lys Lys Gly Asn Asn 
625                 630                 635                 640 


Lys Ile Phe Glu Asp Arg Asn Lys Ala Glu Phe Ile Arg Asn Ile Glu 
                645                 650                 655     


Ser Gly Ala Tyr Glu Lys Met Ala Tyr Lys Tyr Leu Pro Asp Val Ala 
            660                 665                 670         


Lys Met Ile Pro Lys Cys Ser Thr Gln Leu Asn Glu Ala Lys Asn His 
        675                 680                 685             


Phe Arg Asn Ser Ala Asp Asp Leu Glu Ile Lys Lys Ser Phe Ser Asn 
    690                 695                 700                 


Pro Leu Lys Ile Thr Lys Arg Ile Phe Asp Leu Asn Asn Ile Gln Tyr 
705                 710                 715                 720 


Asp Lys Thr Asn Val Ser Lys Lys Ile Ser Gly Asp Asn Lys Gly Ile 
                725                 730                 735     


Lys Ile Phe Gln Lys Glu Tyr Tyr Lys Ile Ser Gly Asp Phe Asp Val 
            740                 745                 750         


Tyr Lys Ser Ala Leu Asn Asp Trp Ile Asp Phe Cys Lys Asp Phe Leu 
        755                 760                 765             


Ser Lys Tyr Asp Ser Thr Lys Asp Phe Asp Phe Ser Ile Leu Arg Lys 
    770                 775                 780                 


Thr Lys Asp Tyr Lys Ser Leu Asp Glu Phe Tyr Val Asp Val Ala Lys 
785                 790                 795                 800 


Ile Thr Tyr Lys Ile Ser Phe Thr Pro Val Ser Glu Ser Tyr Ile Asp 
                805                 810                 815     


Gln Lys Asn Lys Asn Gly Glu Leu Tyr Leu Phe Glu Ile Tyr Asn Gln 
            820                 825                 830         


Asp Phe Ala Lys Gly Lys Met Gly Ala Lys Asn Leu His Thr Leu Tyr 
        835                 840                 845             


Phe Glu Asn Val Phe Ser Pro Glu Asn Ile Ser Lys Asn Phe Pro Ile 
    850                 855                 860                 


Lys Leu Asn Gly Asn Ala Glu Leu Phe Phe Arg Pro Lys Ser Ile Glu 
865                 870                 875                 880 


Ser Lys Lys Glu Lys Arg Asn Phe Val Arg Glu Ile Val Asn Lys Lys 
                885                 890                 895     


Arg Tyr Ser Glu Asp Lys Ile Phe Phe His Cys Pro Ile Thr Leu Asn 
            900                 905                 910         


Arg Glu Thr Gly Ser Ile Tyr Arg Phe Asn Asn Tyr Val Asn Asn Phe 
        915                 920                 925             


Leu Ser Glu Asn Asn Ile Asn Ile Ile Gly Val Asp Arg Gly Glu Lys 
    930                 935                 940                 


His Leu Ala Tyr Tyr Ser Val Ile Asp Lys Asn Gly Val Lys Ile Gly 
945                 950                 955                 960 


Gly Gly Ser Phe Asn Glu Ile Asn Lys Val Asp Tyr Ala Lys Lys Leu 
                965                 970                 975     


Glu Glu Arg Ala Gly Glu Arg Glu Gln Ser Arg Lys Asp Trp Gln Val 
            980                 985                 990         


Val Glu Gly Ile Lys Asp Leu Lys  Lys Gly Tyr Ile Ser  Gln Val Val 
        995                 1000                 1005             


Arg Glu  Leu Ala Asp Leu Ala  Ile Lys His Asn Ala  Ile Ile Val 
    1010                 1015                 1020             


Leu Glu  Asp Leu Asn Met Arg  Phe Lys Gln Ile Arg  Gly Gly Ile 
    1025                 1030                 1035             


Glu Lys  Ser Ile Tyr Gln Gln  Leu Glu Lys Ala Leu  Ile Asp Lys 
    1040                 1045                 1050             


Leu Ser  Phe Leu Val Glu Lys  Gly Glu Lys Asp Pro  Asn Gln Ala 
    1055                 1060                 1065             


Gly His  Ile Leu Lys Ala Tyr  Gln Leu Ala Ala Pro  Phe Thr Ser 
    1070                 1075                 1080             


Phe Lys  Asp Met Gly Lys Gln  Thr Gly Ile Val Phe  Tyr Thr Gln 
    1085                 1090                 1095             


Ala Ser  Tyr Thr Ser Lys Thr  Cys Pro Asn Cys Gly  Phe Arg Lys 
    1100                 1105                 1110             


Asn Asn  Asn Lys Phe Tyr Phe  Glu Asn Asn Ile Gly  Lys Ala Gln 
    1115                 1120                 1125             


Asp Ala  Leu Lys Lys Leu Lys  Thr Phe Glu Tyr Asp  Ser Glu Asn 
    1130                 1135                 1140             


Lys Cys  Phe Gly Leu Ser Tyr  Cys Leu Ser Asp Phe  Ala Asn Lys 
    1145                 1150                 1155             


Glu Glu  Val Glu Lys Asn Lys  Asn Lys Lys Arg Asn  Asn Ala Pro 
    1160                 1165                 1170             


Tyr Ser  Asp Ile Glu Lys Lys  Asp Cys Phe Glu Leu  Ser Thr Lys 
    1175                 1180                 1185             


Asp Ala  Val Arg Tyr Arg Trp  His Asp Lys Asn Thr  Glu Arg Gly 
    1190                 1195                 1200             


Lys Thr  Phe Phe Glu Gly Glu  Ser Val Tyr Glu Glu  Lys Glu Glu 
    1205                 1210                 1215             


Lys Glu  Ile Gly Gln Thr Lys  Arg Gly Leu Val Lys  Glu Tyr Asp 
    1220                 1225                 1230             


Ile Ser  Lys Cys Leu Ile Gly  Leu Phe Glu Lys Thr  Gly Leu Asp 
    1235                 1240                 1245             


Tyr Lys  Gln Asn Leu Leu Asp  Lys Ile Asn Ser Gly  Lys Phe Asp 
    1250                 1255                 1260             


Gly Thr  Phe Tyr Lys Asn Leu  Phe Asn Tyr Leu Asn  Leu Leu Phe 
    1265                 1270                 1275             


Glu Ile  Arg Asn Ser Ile Ser  Gly Thr Glu Ile Asp  Tyr Ile Ser 
    1280                 1285                 1290             


Cys Pro  Glu Cys Gln Phe His  Thr Asp Lys Ser Lys  Thr Ile Lys 
    1295                 1300                 1305             


Asn Gly  Asp Asp Asn Gly Ser  Tyr Asn Ile Ala Arg  Lys Gly Met 
    1310                 1315                 1320             


Ile Ile  Leu Asp Lys Ile Lys  Gln Phe Lys Lys Glu  Asn Gly Ser 
    1325                 1330                 1335             


Leu Asp  Lys Met Gly Trp Gly  Glu Leu Phe Ile Asp  Leu Glu Glu 
    1340                 1345                 1350             


Trp Asp  Lys Phe Ala Gln Lys  Lys Asn Asn Asn Ile  Ile Asp Lys 
    1355                 1360                 1365             


<210>  53
<211>  1257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  53

Met Lys Tyr Thr Asp Phe Thr Gly Ile Tyr Ser Val Ser Lys Thr Leu 
1               5                   10                  15      


Arg Phe Glu Leu Ile Pro Gln Gly Ser Thr Val Glu Asn Met Lys Arg 
            20                  25                  30          


Glu Gly Ile Leu Asn Asn Asp Met His Arg Ala Asp Ser Tyr Lys Glu 
        35                  40                  45              


Met Lys Lys Leu Ile Asp Glu Tyr His Lys Ala Phe Ile Glu Arg Cys 
    50                  55                  60                  


Leu Ser Asp Phe Ser Leu Lys Tyr Asp Asp Thr Gly Lys His Asp Ser 
65                  70                  75                  80  


Leu Glu Glu Tyr Phe Phe Tyr Tyr Glu Gln Lys Arg Asn Asp Lys Thr 
                85                  90                  95      


Lys Lys Ile Phe Glu Asp Ile Gln Val Ala Leu Arg Lys Gln Ile Ser 
            100                 105                 110         


Lys Arg Phe Thr Gly Asp Thr Ala Phe Lys Arg Leu Phe Lys Lys Glu 
        115                 120                 125             


Leu Ile Lys Glu Asp Leu Pro Ser Phe Val Lys Asn Asp Pro Val Lys 
    130                 135                 140                 


Thr Glu Leu Ile Lys Glu Phe Ser Asp Phe Thr Thr Tyr Phe Gln Glu 
145                 150                 155                 160 


Phe His Lys Asn Arg Lys Asn Met Tyr Thr Ser Asp Ala Lys Ser Thr 
                165                 170                 175     


Ala Ile Ala Tyr Arg Ile Ile Asn Glu Asn Leu Pro Lys Phe Ile Asp 
            180                 185                 190         


Asn Ile Asn Ala Phe Asp Ile Val Ala Lys Val Pro Glu Met Gln Glu 
        195                 200                 205             


His Phe Lys Thr Ile Ala Asp Glu Leu Arg Ser His Leu Gln Val Gly 
    210                 215                 220                 


Asn Asp Ile Asp Lys Met Phe Asn Leu Gln Phe Phe Asn Lys Val Leu 
225                 230                 235                 240 


Thr Gln Ser Gln Leu Asp Val Tyr Asn Ala Val Ile Gly Gly Lys Ser 
                245                 250                 255     


Glu Gly Asn Lys Lys Ile Gln Gly Ile Asn Glu Tyr Ile Asn Leu Tyr 
            260                 265                 270         


Asn Gln Gln His Lys Lys Ala Arg Leu Pro Met Leu Lys Leu Leu Tyr 
        275                 280                 285             


Lys Gln Ile Leu Ser Asp Arg Val Ala Ile Ser Trp Leu Gln Asp Glu 
    290                 295                 300                 


Phe Asp Asn Asp Gln Asp Met Leu Asp Thr Ile Glu Ala Phe Tyr Asn 
305                 310                 315                 320 


Lys Leu Asn Ser Asn Glu Thr Gly Val Leu Gly Glu Gly Lys Leu Lys 
                325                 330                 335     


Gln Ile Leu Met Gly Leu Asp Gly Tyr Asn Leu Asp Gly Val Phe Met 
            340                 345                 350         


Arg Asn Asp Leu Gln Leu Ser Glu Val Ser Gln Arg Leu Cys Gly Gly 
        355                 360                 365             


Trp Asn Ile Ile Lys Asp Ala Met Thr Ser Asp Leu Lys Arg Ser Val 
    370                 375                 380                 


Gln Lys Lys Lys Lys Glu Thr Asp Ala Asp Phe Glu Glu Arg Val Ser 
385                 390                 395                 400 


Lys Leu Phe Ser Ala Gln Asn Ser Phe Ser Ile Ala Tyr Ile Asn Gln 
                405                 410                 415     


Cys Leu Gly Gln Ala Gly Ile Arg Cys Lys Ile Gln Asp Tyr Phe Ala 
            420                 425                 430         


Cys Leu Gly Ala Lys Glu Gly Glu Asn Glu Ala Glu Thr Thr Pro Asp 
        435                 440                 445             


Ile Phe Asp Gln Ile Ala Glu Ala Tyr His Gly Ala Ala Pro Ile Leu 
    450                 455                 460                 


Asn Ala Arg Pro Ser Ser His Asn Leu Ala Gln Asp Ile Glu Lys Val 
465                 470                 475                 480 


Lys Ala Ile Lys Ala Leu Leu Asp Ala Leu Lys Arg Leu Gln Arg Phe 
                485                 490                 495     


Val Lys Pro Leu Leu Gly Arg Gly Asp Glu Gly Asp Lys Asp Asn Phe 
            500                 505                 510         


Phe Tyr Gly Asp Phe Met Pro Ile Trp Glu Val Leu Asp Gln Leu Thr 
        515                 520                 525             


Pro Leu Tyr Asn Lys Val Arg Asn Arg Met Thr Arg Lys Pro Tyr Ser 
    530                 535                 540                 


Gln Glu Lys Ile Lys Leu Asn Phe Glu Asn Ser Thr Leu Leu Asn Gly 
545                 550                 555                 560 


Trp Asp Leu Asn Lys Glu His Asp Asn Thr Ser Val Ile Leu Arg Arg 
                565                 570                 575     


Glu Gly Leu Tyr Tyr Leu Gly Ile Met Asn Lys Asn Tyr Asn Lys Ile 
            580                 585                 590         


Phe Asp Ala Asn Asn Val Glu Thr Ile Gly Asp Cys Tyr Glu Lys Met 
        595                 600                 605             


Ile Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu Pro Lys Val Phe 
    610                 615                 620                 


Phe Ser Lys Ser Arg Val Gln Glu Phe Ser Pro Ser Lys Lys Ile Leu 
625                 630                 635                 640 


Glu Ile Trp Glu Ser Lys Ser Phe Lys Lys Gly Asp Asn Phe Asn Leu 
                645                 650                 655     


Asp Asp Cys His Ala Leu Ile Asp Phe Tyr Lys Asp Ser Ile Ala Lys 
            660                 665                 670         


His Pro Asp Trp Asn Lys Phe Asn Phe Lys Phe Ser Asp Thr Gln Ser 
        675                 680                 685             


Tyr Thr Asn Ile Ser Asp Phe Tyr Arg Asp Val Asn Gln Gln Gly Tyr 
    690                 695                 700                 


Ser Leu Ser Phe Thr Lys Val Ser Val Asp Tyr Val Asn Arg Met Val 
705                 710                 715                 720 


Asp Glu Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser 
                725                 730                 735     


Pro Gln Ser Lys Gly Thr Pro Asn Met His Thr Leu Tyr Trp Arg Met 
            740                 745                 750         


Leu Phe Asp Glu Arg Asn Leu His Asn Val Ile Tyr Lys Leu Asn Gly 
        755                 760                 765             


Glu Ala Glu Val Phe Tyr Arg Lys Ala Ser Leu Arg Cys Asp Arg Pro 
    770                 775                 780                 


Thr His Pro Ala His Gln Pro Ile Thr Cys Lys Asn Glu Asn Asp Ser 
785                 790                 795                 800 


Lys Arg Val Cys Val Phe Asp Tyr Asp Ile Ile Lys Asn Arg Arg Tyr 
                805                 810                 815     


Thr Val Asp Lys Phe Met Phe His Val Pro Ile Thr Ile Asn Tyr Lys 
            820                 825                 830         


Cys Thr Gly Ser Asp Asn Ile Asn Gln Gln Val Cys Asp Tyr Leu Arg 
        835                 840                 845             


Ser Ala Gly Asp Asp Thr His Ile Ile Gly Ile Asp Arg Gly Glu Arg 
    850                 855                 860                 


Asn Leu Leu Tyr Leu Val Ile Ile Asp Gln His Gly Thr Ile Lys Glu 
865                 870                 875                 880 


Gln Phe Ser Leu Asn Glu Ile Val Asn Glu Tyr Lys Gly Asn Thr Tyr 
                885                 890                 895     


Cys Thr Asn Tyr His Ser Leu Leu Glu Glu Lys Glu Ala Gly Asn Lys 
            900                 905                 910         


Lys Ala Arg Gln Asp Trp Gln Thr Ile Glu Ser Ile Lys Glu Leu Lys 
        915                 920                 925             


Glu Gly Tyr Leu Ser Gln Val Ile His Lys Ile Ser Met Leu Met Gln 
    930                 935                 940                 


Arg Tyr His Ala Ile Val Val Leu Glu Asp Leu Asn Gly Ser Phe Met 
945                 950                 955                 960 


Arg Ser Arg Gln Lys Val Glu Lys Gln Val Tyr Gln Lys Phe Glu His 
                965                 970                 975     


Met Leu Ile Asn Lys Leu Asn Tyr Leu Val Asn Lys Gln Tyr Asp Ala 
            980                 985                 990         


Thr Glu Pro Gly Gly Leu Leu His  Ala Leu Gln Leu Thr  Ser Arg Met 
        995                 1000                 1005             


Asp Ser  Phe Lys Lys Leu Gly  Lys Gln Ser Gly Phe  Leu Phe Tyr 
    1010                 1015                 1020             


Ile Pro  Ala Trp Asn Thr Ser  Lys Ile Asp Pro Val  Thr Gly Phe 
    1025                 1030                 1035             


Val Asn  Leu Phe Asp Thr Arg  Tyr Cys Asn Glu Ala  Lys Ala Lys 
    1040                 1045                 1050             


Glu Phe  Phe Glu Lys Phe Asp  Asp Ile Ser Tyr Asn  Asp Glu Arg 
    1055                 1060                 1065             


Asp Trp  Phe Glu Phe Ser Phe  Asp Tyr Arg His Phe  Thr Asn Lys 
    1070                 1075                 1080             


Pro Thr  Gly Thr Arg Thr Gln  Trp Thr Leu Cys Thr  Gln Gly Thr 
    1085                 1090                 1095             


Arg Val  Arg Thr Phe Arg Asn  Pro Glu Lys Ser Asn  His Trp Asp 
    1100                 1105                 1110             


Asn Glu  Glu Phe Asp Leu Thr  Gln Ala Phe Lys Asp  Leu Phe Asn 
    1115                 1120                 1125             


Lys Tyr  Gly Ile Asp Ile Ala  Ser Gly Leu Lys Ala  Arg Ile Val 
    1130                 1135                 1140             


Asn Gly  Gln Leu Thr Lys Glu  Thr Ser Ala Val Lys  Asp Phe Tyr 
    1145                 1150                 1155             


Glu Ser  Leu Leu Lys Leu Leu  Lys Leu Thr Leu Gln  Met Arg Asn 
    1160                 1165                 1170             


Ser Val  Thr Gly Thr Asp Ile  Asp Tyr Leu Val Ser  Pro Val Ala 
    1175                 1180                 1185             


Asp Lys  Asp Gly Ile Phe Phe  Asp Ser Arg Thr Cys  Gly Ser Leu 
    1190                 1195                 1200             


Leu Pro  Ala Asn Ala Asp Ala  Asn Gly Ala Phe Asn  Ile Ala Arg 
    1205                 1210                 1215             


Lys Gly  Leu Met Leu Leu Arg  Gln Ile Gln Gln Ser  Ser Ile Asp 
    1220                 1225                 1230             


Ala Glu  Lys Ile Gln Leu Ala  Pro Ile Lys Asn Glu  Asp Trp Leu 
    1235                 1240                 1245             


Glu Phe  Ala Gln Glu Lys Pro  Tyr Leu 
    1250                 1255         


<210>  54
<211>  766
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  54

Met Glu Lys Glu Ile Thr Glu Leu Thr Lys Ile Arg Arg Glu Phe Pro 
1               5                   10                  15      


Asn Lys Lys Phe Ser Ser Thr Asp Met Lys Lys Ala Gly Lys Leu Leu 
            20                  25                  30          


Lys Ala Glu Gly Pro Asp Ala Val Arg Asp Phe Leu Asn Ser Cys Gln 
        35                  40                  45              


Glu Ile Ile Gly Asp Phe Lys Pro Pro Val Lys Thr Asn Ile Val Ser 
    50                  55                  60                  


Ile Ser Arg Pro Phe Glu Glu Trp Pro Val Ser Met Val Gly Arg Ala 
65                  70                  75                  80  


Ile Gln Glu Tyr Tyr Phe Ser Leu Thr Lys Glu Glu Leu Glu Ser Val 
                85                  90                  95      


His Pro Gly Thr Ser Ser Glu Asp His Lys Ser Phe Phe Asn Ile Thr 
            100                 105                 110         


Gly Leu Ser Asn Tyr Asn Tyr Thr Ser Val Gln Gly Leu Asn Leu Ile 
        115                 120                 125             


Phe Lys Asn Ala Lys Ala Ile Tyr Asp Gly Thr Leu Val Lys Ala Asn 
    130                 135                 140                 


Asn Lys Asn Lys Lys Leu Glu Lys Lys Phe Asn Glu Ile Asn His Lys 
145                 150                 155                 160 


Arg Ser Leu Glu Gly Leu Pro Ile Ile Thr Pro Asp Phe Glu Glu Pro 
                165                 170                 175     


Phe Asp Glu Asn Gly His Leu Asn Asn Pro Pro Gly Ile Asn Arg Asn 
            180                 185                 190         


Ile Tyr Gly Tyr Gln Gly Cys Ala Ala Lys Val Phe Val Pro Ser Lys 
        195                 200                 205             


His Lys Met Val Ser Leu Pro Lys Glu Tyr Glu Gly Tyr Asn Arg Asp 
    210                 215                 220                 


Pro Asn Leu Ser Leu Ala Gly Phe Arg Asn Arg Leu Glu Ile Pro Glu 
225                 230                 235                 240 


Gly Glu Pro Gly His Val Pro Trp Phe Gln Arg Met Asp Ile Pro Glu 
                245                 250                 255     


Gly Gln Ile Gly His Val Asn Lys Ile Gln Arg Phe Asn Phe Val His 
            260                 265                 270         


Gly Lys Asn Ser Gly Lys Val Lys Phe Ser Asp Lys Thr Gly Arg Val 
        275                 280                 285             


Lys Arg Tyr His His Ser Lys Tyr Lys Asp Ala Thr Lys Pro Tyr Lys 
    290                 295                 300                 


Phe Leu Glu Glu Ser Lys Lys Val Ser Ala Leu Asp Ser Ile Leu Ala 
305                 310                 315                 320 


Ile Ile Thr Ile Gly Asp Asp Trp Val Val Phe Asp Ile Arg Gly Leu 
                325                 330                 335     


Tyr Arg Asn Val Phe Tyr Arg Glu Leu Ala Gln Lys Gly Leu Thr Ala 
            340                 345                 350         


Val Gln Leu Leu Asp Leu Phe Thr Gly Asp Pro Val Ile Asp Pro Lys 
        355                 360                 365             


Lys Gly Val Val Thr Phe Ser Tyr Lys Glu Gly Val Val Pro Val Phe 
    370                 375                 380                 


Ser Gln Lys Ile Val Pro Arg Phe Lys Ser Arg Asp Thr Leu Glu Lys 
385                 390                 395                 400 


Leu Thr Ser Gln Gly Pro Val Ala Leu Leu Ser Val Asp Leu Gly Gln 
                405                 410                 415     


Asn Glu Pro Val Ala Ala Arg Val Cys Ser Leu Lys Asn Ile Asn Asp 
            420                 425                 430         


Lys Ile Thr Leu Asp Asn Ser Cys Arg Ile Ser Phe Leu Asp Asp Tyr 
        435                 440                 445             


Lys Lys Gln Ile Lys Asp Tyr Arg Asp Ser Leu Asp Glu Leu Glu Ile 
    450                 455                 460                 


Lys Ile Arg Leu Glu Ala Ile Asn Ser Leu Glu Thr Asn Gln Gln Val 
465                 470                 475                 480 


Glu Ile Arg Asp Leu Asp Val Phe Ser Ala Asp Arg Ala Lys Ala Asn 
                485                 490                 495     


Thr Val Asp Met Phe Asp Ile Asp Pro Asn Leu Ile Ser Trp Asp Ser 
            500                 505                 510         


Met Ser Asp Ala Arg Val Ser Thr Gln Ile Ser Asp Leu Tyr Leu Lys 
        515                 520                 525             


Asn Gly Gly Asp Glu Ser Arg Val Tyr Phe Glu Ile Asn Asn Lys Arg 
    530                 535                 540                 


Ile Lys Arg Ser Asp Tyr Asn Ile Ser Gln Leu Val Arg Pro Lys Leu 
545                 550                 555                 560 


Ser Asp Ser Thr Arg Lys Asn Leu Asn Asp Ser Ile Trp Lys Leu Lys 
                565                 570                 575     


Arg Thr Ser Glu Glu Tyr Leu Lys Leu Ser Lys Arg Lys Leu Glu Leu 
            580                 585                 590         


Ser Arg Ala Val Val Asn Tyr Thr Ile Arg Gln Ser Lys Leu Leu Ser 
        595                 600                 605             


Gly Ile Asn Asp Ile Val Ile Ile Leu Glu Asp Leu Asp Val Lys Lys 
    610                 615                 620                 


Lys Phe Asn Gly Arg Gly Ile Arg Asp Ile Gly Trp Asp Asn Phe Phe 
625                 630                 635                 640 


Ser Ser Arg Lys Glu Asn Arg Trp Phe Ile Pro Ala Phe His Lys Ala 
                645                 650                 655     


Phe Ser Glu Leu Ser Ser Asn Arg Gly Leu Cys Val Ile Glu Val Asn 
            660                 665                 670         


Pro Ala Trp Thr Ser Ala Thr Cys Pro Asp Cys Gly Phe Cys Ser Lys 
        675                 680                 685             


Glu Asn Arg Asp Gly Ile Asn Phe Thr Cys Arg Lys Cys Gly Val Ser 
    690                 695                 700                 


Tyr His Ala Asp Ile Asp Val Ala Thr Leu Asn Ile Ala Arg Val Ala 
705                 710                 715                 720 


Val Leu Gly Lys Pro Met Ser Gly Pro Ala Asp Arg Glu Arg Leu Gly 
                725                 730                 735     


Asp Thr Lys Lys Pro Arg Val Ala Arg Ser Arg Lys Thr Met Lys Arg 
            740                 745                 750         


Lys Asp Ile Ser Asn Ser Thr Val Glu Ala Met Val Thr Ala 
        755                 760                 765     


<210>  55
<211>  717
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  55

Met Ile Lys Pro Thr Val Ser Gln Phe Leu Thr Pro Gly Phe Lys Leu 
1               5                   10                  15      


Ile Arg Asn His Ser Arg Thr Ala Gly Leu Lys Leu Lys Asn Glu Gly 
            20                  25                  30          


Glu Glu Ala Cys Lys Lys Phe Val Arg Glu Asn Glu Ile Pro Lys Asp 
        35                  40                  45              


Glu Cys Pro Asn Phe Gln Gly Gly Pro Ala Ile Ala Asn Ile Ile Ala 
    50                  55                  60                  


Lys Ser Arg Glu Phe Thr Glu Trp Glu Ile Tyr Gln Ser Ser Leu Ala 
65                  70                  75                  80  


Ile Gln Glu Val Ile Phe Thr Leu Pro Lys Asp Lys Leu Pro Glu Pro 
                85                  90                  95      


Ile Leu Lys Glu Glu Trp Arg Ala Gln Trp Leu Ser Glu His Gly Leu 
            100                 105                 110         


Asp Thr Val Pro Tyr Lys Glu Ala Ala Gly Leu Asn Leu Ile Ile Lys 
        115                 120                 125             


Asn Ala Val Asn Thr Tyr Lys Gly Val Gln Val Lys Val Asp Asn Lys 
    130                 135                 140                 


Asn Lys Asn Asn Leu Ala Lys Ile Asn Arg Lys Asn Glu Ile Ala Lys 
145                 150                 155                 160 


Leu Asn Gly Glu Gln Glu Ile Ser Phe Glu Glu Ile Lys Ala Phe Asp 
                165                 170                 175     


Asp Lys Gly Tyr Leu Leu Gln Lys Pro Ser Pro Asn Lys Ser Ile Tyr 
            180                 185                 190         


Cys Tyr Gln Ser Val Ser Pro Lys Pro Phe Ile Thr Ser Lys Tyr His 
        195                 200                 205             


Asn Val Asn Leu Pro Glu Glu Tyr Ile Gly Tyr Tyr Arg Lys Ser Asn 
    210                 215                 220                 


Glu Pro Ile Val Ser Pro Tyr Gln Phe Asp Arg Leu Arg Ile Pro Ile 
225                 230                 235                 240 


Gly Glu Pro Gly Tyr Val Pro Lys Trp Gln Tyr Thr Phe Leu Ser Lys 
                245                 250                 255     


Lys Glu Asn Lys Arg Arg Lys Leu Ser Lys Arg Ile Lys Asn Val Ser 
            260                 265                 270         


Pro Ile Leu Gly Ile Ile Cys Ile Lys Lys Asp Trp Cys Val Phe Asp 
        275                 280                 285             


Met Arg Gly Leu Leu Arg Thr Asn His Trp Lys Lys Tyr His Lys Pro 
    290                 295                 300                 


Thr Asp Ser Ile Asn Asp Leu Phe Asp Tyr Phe Thr Gly Asp Pro Val 
305                 310                 315                 320 


Ile Asp Thr Lys Ala Asn Val Val Arg Phe Arg Tyr Lys Met Glu Asn 
                325                 330                 335     


Gly Ile Val Asn Tyr Lys Pro Val Arg Glu Lys Lys Gly Lys Glu Leu 
            340                 345                 350         


Leu Glu Asn Ile Cys Asp Gln Asn Gly Ser Cys Lys Leu Ala Thr Val 
        355                 360                 365             


Asp Val Gly Gln Asn Asn Pro Val Ala Ile Gly Leu Phe Glu Leu Lys 
    370                 375                 380                 


Lys Val Asn Gly Glu Leu Thr Lys Thr Leu Ile Ser Arg His Pro Thr 
385                 390                 395                 400 


Pro Ile Asp Phe Cys Asn Lys Ile Thr Ala Tyr Arg Glu Arg Tyr Asp 
                405                 410                 415     


Lys Leu Glu Ser Ser Ile Lys Leu Asp Ala Ile Lys Gln Leu Thr Ser 
            420                 425                 430         


Glu Gln Lys Ile Glu Val Asp Asn Tyr Asn Asn Asn Phe Thr Pro Gln 
        435                 440                 445             


Asn Thr Lys Gln Ile Val Cys Ser Lys Leu Asn Ile Asn Pro Asn Asp 
    450                 455                 460                 


Leu Pro Trp Asp Lys Met Ile Ser Gly Thr His Phe Ile Ser Glu Lys 
465                 470                 475                 480 


Ala Gln Val Ser Asn Lys Ser Glu Ile Tyr Phe Thr Ser Thr Asp Lys 
                485                 490                 495     


Gly Lys Thr Lys Asp Val Met Lys Ser Asp Tyr Lys Trp Phe Gln Asp 
            500                 505                 510         


Tyr Lys Pro Lys Leu Ser Lys Glu Val Arg Asp Ala Leu Ser Asp Ile 
        515                 520                 525             


Glu Trp Arg Leu Arg Arg Glu Ser Leu Glu Phe Asn Lys Leu Ser Lys 
    530                 535                 540                 


Ser Arg Glu Gln Asp Ala Arg Gln Leu Ala Asn Trp Ile Ser Ser Met 
545                 550                 555                 560 


Cys Asp Val Ile Gly Ile Glu Asn Leu Val Lys Lys Asn Asn Phe Phe 
                565                 570                 575     


Gly Gly Ser Gly Lys Arg Glu Pro Gly Trp Asp Asn Phe Tyr Lys Pro 
            580                 585                 590         


Lys Lys Glu Asn Arg Trp Trp Ile Asn Ala Ile His Lys Ala Leu Thr 
        595                 600                 605             


Glu Leu Ser Gln Asn Lys Gly Lys Arg Val Ile Leu Leu Pro Ala Met 
    610                 615                 620                 


Arg Thr Ser Ile Thr Cys Pro Lys Cys Lys Tyr Cys Asp Ser Lys Asn 
625                 630                 635                 640 


Arg Asn Gly Glu Lys Phe Asn Cys Leu Lys Cys Gly Ile Glu Leu Asn 
                645                 650                 655     


Ala Asp Ile Asp Val Ala Thr Glu Asn Leu Ala Thr Val Ala Ile Thr 
            660                 665                 670         


Ala Gln Ser Met Pro Lys Pro Thr Cys Glu Arg Ser Gly Asp Ala Lys 
        675                 680                 685             


Lys Pro Val Arg Ala Arg Lys Ala Lys Ala Pro Glu Phe His Asp Lys 
    690                 695                 700                 


Leu Ala Pro Ser Tyr Thr Val Val Leu Arg Glu Ala Val 
705                 710                 715         


<210>  56
<211>  766
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  56

Met Glu Lys Glu Ile Thr Glu Leu Thr Lys Ile Arg Arg Glu Phe Pro 
1               5                   10                  15      


Asn Lys Lys Phe Ser Ser Thr Asp Met Lys Lys Ala Gly Lys Leu Leu 
            20                  25                  30          


Lys Ala Glu Gly Pro Asp Ala Val Arg Asp Phe Leu Asn Ser Cys Gln 
        35                  40                  45              


Glu Ile Ile Gly Asp Phe Lys Pro Pro Val Lys Thr Asn Ile Val Ser 
    50                  55                  60                  


Ile Ser Arg Pro Phe Glu Glu Trp Pro Val Ser Met Val Gly Arg Ala 
65                  70                  75                  80  


Ile Gln Glu Tyr Tyr Phe Ser Leu Thr Lys Glu Glu Leu Glu Ser Val 
                85                  90                  95      


His Pro Gly Thr Ser Ser Glu Asp His Lys Ser Phe Phe Asn Ile Thr 
            100                 105                 110         


Gly Leu Ser Asn Tyr Asn Tyr Thr Ser Val Gln Gly Leu Asn Leu Ile 
        115                 120                 125             


Phe Lys Asn Ala Lys Ala Ile Tyr Asp Gly Thr Leu Val Lys Ala Asn 
    130                 135                 140                 


Asn Lys Asn Lys Lys Leu Glu Lys Lys Phe Asn Glu Ile Asn His Lys 
145                 150                 155                 160 


Arg Ser Leu Glu Gly Leu Pro Ile Ile Thr Pro Asp Phe Glu Glu Pro 
                165                 170                 175     


Phe Asp Glu Asn Gly His Leu Asn Asn Pro Pro Gly Ile Asn Arg Asn 
            180                 185                 190         


Ile Tyr Gly Tyr Gln Gly Cys Ala Ala Lys Val Phe Val Pro Ser Lys 
        195                 200                 205             


His Lys Met Val Ser Leu Pro Lys Glu Tyr Glu Gly Tyr Asn Arg Asp 
    210                 215                 220                 


Pro Asn Leu Ser Leu Ala Gly Phe Arg Asn Arg Leu Glu Ile Pro Glu 
225                 230                 235                 240 


Gly Glu Pro Gly His Val Pro Trp Phe Gln Arg Met Asp Ile Pro Glu 
                245                 250                 255     


Gly Gln Ile Gly His Val Asn Lys Ile Gln Arg Phe Asn Phe Val His 
            260                 265                 270         


Gly Lys Asn Ser Gly Lys Val Lys Phe Ser Asp Lys Thr Gly Arg Val 
        275                 280                 285             


Lys Arg Tyr His His Ser Lys Tyr Lys Asp Ala Thr Lys Pro Tyr Lys 
    290                 295                 300                 


Phe Leu Glu Glu Ser Lys Lys Val Ser Ala Leu Asp Ser Ile Leu Ala 
305                 310                 315                 320 


Ile Ile Thr Ile Gly Asp Asp Trp Val Val Phe Asp Ile Arg Gly Leu 
                325                 330                 335     


Tyr Arg Asn Val Phe Tyr Arg Glu Leu Ala Gln Lys Gly Leu Thr Ala 
            340                 345                 350         


Val Gln Leu Leu Asp Leu Phe Thr Gly Asp Pro Val Ile Asp Pro Lys 
        355                 360                 365             


Lys Gly Val Val Thr Phe Ser Tyr Lys Glu Gly Val Val Pro Val Phe 
    370                 375                 380                 


Ser Gln Lys Ile Val Pro Arg Phe Lys Ser Arg Asp Thr Leu Glu Lys 
385                 390                 395                 400 


Leu Thr Ser Gln Gly Pro Val Ala Leu Leu Ser Val Asp Leu Gly Gln 
                405                 410                 415     


Asn Glu Pro Val Ala Ala Arg Val Cys Ser Leu Lys Asn Ile Asn Asp 
            420                 425                 430         


Lys Ile Thr Leu Asp Asn Ser Cys Arg Ile Ser Phe Leu Asp Asp Tyr 
        435                 440                 445             


Lys Lys Gln Ile Lys Asp Tyr Arg Asp Ser Leu Asp Glu Leu Glu Ile 
    450                 455                 460                 


Lys Ile Arg Leu Glu Ala Ile Asn Ser Leu Glu Thr Asn Gln Gln Val 
465                 470                 475                 480 


Glu Ile Arg Asp Leu Asp Val Phe Ser Ala Asp Arg Ala Lys Ala Asn 
                485                 490                 495     


Thr Val Asp Met Phe Asp Ile Asp Pro Asn Leu Ile Ser Trp Asp Ser 
            500                 505                 510         


Met Ser Asp Ala Arg Val Ser Thr Gln Ile Ser Asp Leu Tyr Leu Lys 
        515                 520                 525             


Asn Gly Gly Asp Glu Ser Arg Val Tyr Phe Glu Ile Asn Asn Lys Arg 
    530                 535                 540                 


Ile Lys Arg Ser Asp Tyr Asn Ile Ser Gln Leu Val Arg Pro Lys Leu 
545                 550                 555                 560 


Ser Asp Ser Thr Arg Lys Asn Leu Asn Asp Ser Ile Trp Lys Leu Lys 
                565                 570                 575     


Arg Thr Ser Glu Glu Tyr Leu Lys Leu Ser Lys Arg Lys Leu Glu Leu 
            580                 585                 590         


Ser Arg Ala Val Val Asn Tyr Thr Ile Arg Gln Ser Lys Leu Leu Ser 
        595                 600                 605             


Gly Ile Asn Asp Ile Val Ile Ile Leu Glu Asp Leu Asp Val Lys Lys 
    610                 615                 620                 


Lys Phe Asn Gly Arg Gly Ile Arg Asp Ile Gly Trp Asp Asn Phe Phe 
625                 630                 635                 640 


Ser Ser Arg Lys Glu Asn Arg Trp Phe Ile Pro Ala Phe His Lys Thr 
                645                 650                 655     


Phe Ser Glu Leu Ser Ser Asn Arg Gly Leu Cys Val Ile Glu Val Asn 
            660                 665                 670         


Pro Ala Trp Thr Ser Ala Thr Cys Pro Asp Cys Gly Phe Cys Ser Lys 
        675                 680                 685             


Glu Asn Arg Asp Gly Ile Asn Phe Thr Cys Arg Lys Cys Gly Val Ser 
    690                 695                 700                 


Tyr His Ala Asp Ile Asp Val Ala Thr Leu Asn Ile Ala Arg Val Ala 
705                 710                 715                 720 


Val Leu Gly Lys Pro Met Ser Gly Pro Ala Asp Arg Glu Arg Leu Gly 
                725                 730                 735     


Asp Thr Lys Lys Pro Arg Val Ala Arg Ser Arg Lys Thr Met Lys Arg 
            740                 745                 750         


Lys Asp Ile Ser Asn Ser Thr Val Glu Ala Met Val Thr Ala 
        755                 760                 765     


<210>  57
<211>  718
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  57

Val Pro Asp Lys Lys Glu Thr Pro Leu Val Ala Leu Cys Lys Lys Ser 
1               5                   10                  15      


Phe Pro Gly Leu Arg Phe Lys Lys His Asp Ser Arg Gln Ala Gly Arg 
            20                  25                  30          


Ile Leu Lys Ser Lys Gly Glu Gly Ala Ala Val Ala Phe Leu Glu Gly 
        35                  40                  45              


Lys Gly Gly Thr Thr Gln Pro Asn Phe Lys Pro Pro Val Lys Cys Asn 
    50                  55                  60                  


Ile Val Ala Met Ser Arg Pro Leu Glu Glu Trp Pro Ile Tyr Lys Ala 
65                  70                  75                  80  


Ser Val Val Ile Gln Lys Tyr Val Tyr Ala Gln Ser Tyr Glu Glu Phe 
                85                  90                  95      


Lys Ala Thr Asp Pro Gly Lys Ser Glu Ala Gly Leu Arg Ala Trp Leu 
            100                 105                 110         


Lys Ala Thr Arg Val Asp Thr Asp Gly Tyr Phe Asn Val Gln Gly Leu 
        115                 120                 125             


Asn Leu Ile Phe Gln Asn Ala Arg Ala Thr Tyr Glu Gly Val Leu Lys 
    130                 135                 140                 


Lys Val Glu Asn Arg Asn Ser Lys Lys Val Ala Lys Ile Glu Gln Arg 
145                 150                 155                 160 


Asn Glu His Arg Ala Glu Arg Gly Leu Pro Leu Leu Thr Leu Asp Glu 
                165                 170                 175     


Pro Glu Thr Ala Leu Asp Glu Thr Gly His Leu Arg His Arg Pro Gly 
            180                 185                 190         


Ile Asn Cys Ser Val Phe Gly Tyr Gln His Met Lys Leu Lys Pro Tyr 
        195                 200                 205             


Val Pro Gly Ser Ile Pro Gly Val Thr Gly Tyr Ser Arg Asp Pro Ser 
    210                 215                 220                 


Thr Pro Ile Ala Ala Cys Gly Val Asp Arg Leu Glu Ile Pro Glu Gly 
225                 230                 235                 240 


Gln Pro Gly Tyr Val Pro Pro Trp Asp Arg Glu Asn Leu Ser Val Lys 
                245                 250                 255     


Lys His Arg Arg Lys Arg Ala Ser Trp Ala Arg Ser Arg Gly Gly Ala 
            260                 265                 270         


Ile Asp Asp Asn Met Leu Leu Ala Val Val Arg Val Ala Asp Asp Trp 
        275                 280                 285             


Ala Leu Leu Asp Leu Arg Gly Leu Leu Arg Asn Thr Gln Tyr Arg Lys 
    290                 295                 300                 


Leu Leu Asp Arg Ser Val Pro Val Thr Ile Glu Ser Leu Leu Asn Leu 
305                 310                 315                 320 


Val Thr Asn Asp Pro Thr Leu Ser Val Val Lys Lys Pro Gly Lys Pro 
                325                 330                 335     


Val Arg Tyr Thr Ala Thr Leu Ile Tyr Lys Gln Gly Val Val Pro Val 
            340                 345                 350         


Val Lys Ala Lys Val Val Lys Gly Ser Tyr Val Ser Lys Met Leu Asp 
        355                 360                 365             


Asp Thr Thr Glu Thr Phe Ser Leu Val Gly Val Asp Leu Gly Val Asn 
    370                 375                 380                 


Asn Leu Ile Ala Ala Asn Ala Leu Arg Ile Arg Pro Gly Lys Cys Val 
385                 390                 395                 400 


Glu Arg Leu Gln Ala Phe Thr Leu Pro Glu Gln Thr Val Glu Asp Phe 
                405                 410                 415     


Phe Arg Phe Arg Lys Ala Tyr Asp Lys His Gln Glu Asn Leu Arg Leu 
            420                 425                 430         


Ala Ala Val Arg Ser Leu Thr Ala Glu Gln Gln Ala Glu Val Leu Ala 
        435                 440                 445             


Leu Asp Thr Phe Gly Pro Glu Gln Ala Lys Met Gln Val Cys Gly His 
    450                 455                 460                 


Leu Gly Leu Ser Val Asp Glu Val Pro Trp Asp Lys Val Asn Ser Arg 
465                 470                 475                 480 


Ser Ser Ile Leu Ser Asp Leu Ala Lys Glu Arg Gly Val Asp Asp Thr 
                485                 490                 495     


Leu Tyr Met Phe Pro Phe Phe Lys Gly Lys Gly Lys Lys Arg Lys Thr 
            500                 505                 510         


Glu Ile Arg Lys Arg Trp Asp Val Asn Trp Ala Gln His Phe Arg Pro 
        515                 520                 525             


Gln Leu Thr Ser Glu Thr Arg Lys Ala Leu Asn Glu Ala Lys Trp Glu 
    530                 535                 540                 


Ala Glu Arg Asn Ser Ser Lys Tyr His Gln Leu Ser Ile Arg Lys Lys 
545                 550                 555                 560 


Glu Leu Ser Arg His Cys Val Asn Tyr Val Ile Arg Thr Ala Glu Lys 
                565                 570                 575     


Arg Ala Gln Cys Gly Lys Val Ile Val Ala Val Glu Asp Leu His His 
            580                 585                 590         


Ser Phe Arg Arg Gly Gly Lys Gly Ser Arg Lys Ser Gly Trp Gly Gly 
        595                 600                 605             


Phe Phe Ala Ala Lys Gln Glu Gly Arg Trp Leu Met Asp Ala Leu Phe 
    610                 615                 620                 


Gly Ala Phe Cys Asp Leu Ala Val His Arg Gly Tyr Arg Val Ile Lys 
625                 630                 635                 640 


Val Asp Pro Tyr Asn Thr Ser Arg Thr Cys Pro Glu Cys Gly His Cys 
                645                 650                 655     


Asp Lys Ala Asn Arg Asp Arg Val Asn Arg Glu Ala Phe Ile Cys Val 
            660                 665                 670         


Cys Cys Gly Tyr Arg Gly Asn Ala Asp Ile Asp Val Ala Ala Tyr Asn 
        675                 680                 685             


Ile Ala Met Val Ala Ile Thr Gly Val Ser Leu Arg Lys Ala Ala Arg 
    690                 695                 700                 


Ala Ser Val Ala Ser Thr Pro Leu Glu Ser Leu Ala Ala Glu 
705                 710                 715             


<210>  58
<211>  757
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  58

Met Pro Lys Pro Ala Val Glu Ser Glu Phe Ser Lys Val Leu Lys Lys 
1               5                   10                  15      


His Phe Pro Gly Glu Arg Phe Arg Ser Ser Tyr Met Lys Arg Gly Gly 
            20                  25                  30          


Lys Ile Leu Ala Ala Gln Gly Glu Glu Ala Val Val Ala Tyr Leu Gln 
        35                  40                  45              


Gly Lys Ser Glu Glu Glu Pro Pro Asn Phe Gln Pro Pro Ala Lys Cys 
    50                  55                  60                  


His Val Val Thr Lys Ser Arg Asp Phe Ala Glu Trp Pro Ile Met Lys 
65                  70                  75                  80  


Ala Ser Glu Ala Ile Gln Arg Tyr Ile Tyr Ala Leu Ser Thr Thr Glu 
                85                  90                  95      


Arg Ala Ala Cys Lys Pro Gly Lys Ser Ser Glu Ser His Ala Ala Trp 
            100                 105                 110         


Phe Ala Ala Thr Gly Val Ser Asn His Gly Tyr Ser His Val Gln Gly 
        115                 120                 125             


Leu Asn Leu Ile Phe Asp His Thr Leu Gly Arg Tyr Asp Gly Val Leu 
    130                 135                 140                 


Lys Lys Val Gln Leu Arg Asn Glu Lys Ala Arg Ala Arg Leu Glu Ser 
145                 150                 155                 160 


Ile Asn Ala Ser Arg Ala Asp Glu Gly Leu Pro Glu Ile Lys Ala Glu 
                165                 170                 175     


Glu Glu Glu Val Ala Thr Asn Glu Thr Gly His Leu Leu Gln Pro Pro 
            180                 185                 190         


Gly Ile Asn Pro Ser Phe Tyr Val Tyr Gln Thr Ile Ser Pro Gln Ala 
        195                 200                 205             


Tyr Arg Pro Arg Asp Glu Ile Val Leu Pro Pro Glu Tyr Ala Gly Tyr 
    210                 215                 220                 


Val Arg Asp Pro Asn Ala Pro Ile Pro Leu Gly Val Val Arg Asn Arg 
225                 230                 235                 240 


Cys Asp Ile Gln Lys Gly Cys Pro Gly Tyr Ile Pro Glu Trp Gln Arg 
                245                 250                 255     


Glu Ala Gly Thr Ala Ile Ser Pro Lys Thr Gly Lys Ala Val Thr Val 
            260                 265                 270         


Pro Gly Leu Ser Pro Lys Lys Asn Lys Arg Met Arg Arg Tyr Trp Arg 
        275                 280                 285             


Ser Glu Lys Glu Lys Ala Gln Asp Ala Leu Leu Val Thr Val Arg Ile 
    290                 295                 300                 


Gly Thr Asp Trp Val Val Ile Asp Val Arg Gly Leu Leu Arg Asn Ala 
305                 310                 315                 320 


Arg Trp Arg Thr Ile Ala Pro Lys Asp Ile Ser Leu Asn Ala Leu Leu 
                325                 330                 335     


Asp Leu Phe Thr Gly Asp Pro Val Ile Asp Val Arg Arg Asn Ile Val 
            340                 345                 350         


Thr Phe Thr Tyr Thr Leu Asp Ala Cys Gly Thr Tyr Ala Arg Lys Trp 
        355                 360                 365             


Thr Leu Lys Gly Lys Gln Thr Lys Ala Thr Leu Asp Lys Leu Thr Ala 
    370                 375                 380                 


Thr Gln Thr Val Ala Leu Val Ala Ile Asp Leu Gly Gln Thr Asn Pro 
385                 390                 395                 400 


Ile Ser Ala Gly Ile Ser Arg Val Thr Gln Glu Asn Gly Ala Leu Gln 
                405                 410                 415     


Cys Glu Pro Leu Asp Arg Phe Thr Leu Pro Asp Asp Leu Leu Lys Asp 
            420                 425                 430         


Ile Ser Ala Tyr Arg Ile Ala Trp Asp Arg Asn Glu Glu Glu Leu Arg 
        435                 440                 445             


Ala Arg Ser Val Glu Ala Leu Pro Glu Ala Gln Gln Ala Glu Val Arg 
    450                 455                 460                 


Ala Leu Asp Gly Val Ser Lys Glu Thr Ala Arg Thr Gln Leu Cys Ala 
465                 470                 475                 480 


Asp Phe Gly Leu Asp Pro Lys Arg Leu Pro Trp Asp Lys Met Ser Ser 
                485                 490                 495     


Asn Thr Thr Phe Ile Ser Glu Ala Leu Leu Ser Asn Ser Val Ser Arg 
            500                 505                 510         


Asp Gln Val Phe Phe Thr Pro Ala Pro Lys Lys Gly Ala Lys Lys Lys 
        515                 520                 525             


Ala Pro Val Glu Val Met Arg Lys Asp Arg Thr Trp Ala Arg Ala Tyr 
    530                 535                 540                 


Lys Pro Arg Leu Ser Val Glu Ala Gln Lys Leu Lys Asn Glu Ala Leu 
545                 550                 555                 560 


Trp Ala Leu Lys Arg Thr Ser Pro Glu Tyr Leu Lys Leu Ser Arg Arg 
                565                 570                 575     


Lys Glu Glu Leu Cys Arg Arg Ser Ile Asn Tyr Val Ile Glu Lys Thr 
            580                 585                 590         


Arg Arg Arg Thr Gln Cys Gln Ile Val Ile Pro Val Ile Glu Asp Leu 
        595                 600                 605             


Asn Val Arg Phe Phe His Gly Ser Gly Lys Arg Leu Pro Gly Trp Asp 
    610                 615                 620                 


Asn Phe Phe Thr Ala Lys Lys Glu Asn Arg Trp Phe Ile Gln Gly Leu 
625                 630                 635                 640 


His Lys Ala Phe Ser Asp Leu Arg Thr His Arg Ser Phe Tyr Val Phe 
                645                 650                 655     


Glu Val Arg Pro Glu Arg Thr Ser Ile Thr Cys Pro Lys Cys Gly His 
            660                 665                 670         


Cys Glu Val Gly Asn Arg Asp Gly Glu Ala Phe Gln Cys Leu Ser Cys 
        675                 680                 685             


Gly Lys Thr Cys Asn Ala Asp Leu Asp Val Ala Thr His Asn Leu Thr 
    690                 695                 700                 


Gln Val Ala Leu Thr Gly Lys Thr Met Pro Lys Arg Glu Glu Pro Arg 
705                 710                 715                 720 


Asp Ala Gln Gly Thr Ala Pro Ala Arg Lys Thr Lys Lys Ala Ser Lys 
                725                 730                 735     


Ser Lys Ala Pro Pro Ala Glu Arg Glu Asp Gln Thr Pro Ala Gln Glu 
            740                 745                 750         


Pro Ser Gln Thr Ser 
        755         


<210>  59
<211>  761
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  59

Met Ser Asn Lys Thr Thr Pro Pro Ser Pro Leu Ser Leu Leu Leu Arg 
1               5                   10                  15      


Ala His Phe Pro Gly Leu Lys Phe Glu Ser Gln Asp Tyr Lys Ile Ala 
            20                  25                  30          


Gly Lys Lys Leu Arg Asp Gly Gly Pro Glu Ala Val Ile Ser Tyr Leu 
        35                  40                  45              


Thr Gly Lys Gly Gln Ala Lys Leu Lys Asp Val Lys Pro Pro Ala Lys 
    50                  55                  60                  


Ala Phe Val Ile Ala Gln Ser Arg Pro Phe Ile Glu Trp Asp Leu Val 
65                  70                  75                  80  


Arg Val Ser Arg Gln Ile Gln Glu Lys Ile Phe Gly Ile Pro Ala Thr 
                85                  90                  95      


Lys Gly Arg Pro Lys Gln Asp Gly Leu Ser Glu Thr Ala Phe Asn Glu 
            100                 105                 110         


Ala Val Ala Ser Leu Glu Val Asp Gly Lys Ser Lys Leu Asn Glu Glu 
        115                 120                 125             


Thr Arg Ala Ala Phe Tyr Glu Val Leu Gly Leu Asp Ala Pro Ser Leu 
    130                 135                 140                 


His Ala Gln Ala Gln Asn Ala Leu Ile Lys Ser Ala Ile Ser Ile Arg 
145                 150                 155                 160 


Glu Gly Val Leu Lys Lys Val Glu Asn Arg Asn Glu Lys Asn Leu Ser 
                165                 170                 175     


Lys Thr Lys Arg Arg Lys Glu Ala Gly Glu Glu Ala Thr Phe Val Glu 
            180                 185                 190         


Glu Lys Ala His Asp Glu Arg Gly Tyr Leu Ile His Pro Pro Gly Val 
        195                 200                 205             


Asn Gln Thr Ile Pro Gly Tyr Gln Ala Val Val Ile Lys Ser Cys Pro 
    210                 215                 220                 


Ser Asp Phe Ile Gly Leu Pro Ser Gly Cys Leu Ala Lys Glu Ser Ala 
225                 230                 235                 240 


Glu Ala Leu Thr Asp Tyr Leu Pro His Asp Arg Met Thr Ile Pro Lys 
                245                 250                 255     


Gly Gln Pro Gly Tyr Val Pro Glu Trp Gln His Pro Leu Leu Asn Arg 
            260                 265                 270         


Arg Lys Asn Arg Arg Arg Arg Asp Trp Tyr Ser Ala Ser Leu Asn Lys 
        275                 280                 285             


Pro Lys Ala Thr Cys Ser Lys Arg Ser Gly Thr Pro Asn Arg Lys Asn 
    290                 295                 300                 


Ser Arg Thr Asp Gln Ile Gln Ser Gly Arg Phe Lys Gly Ala Ile Pro 
305                 310                 315                 320 


Val Leu Met Arg Phe Gln Asp Glu Trp Val Ile Ile Asp Ile Arg Gly 
                325                 330                 335     


Leu Leu Arg Asn Ala Arg Tyr Arg Lys Leu Leu Lys Glu Lys Ser Thr 
            340                 345                 350         


Ile Pro Asp Leu Leu Ser Leu Phe Thr Gly Asp Pro Ser Ile Asp Met 
        355                 360                 365             


Arg Gln Gly Val Cys Thr Phe Ile Tyr Lys Ala Gly Gln Ala Cys Ser 
    370                 375                 380                 


Ala Lys Met Val Lys Thr Lys Asn Ala Pro Glu Ile Leu Ser Glu Leu 
385                 390                 395                 400 


Thr Lys Ser Gly Pro Val Val Leu Val Ser Ile Asp Leu Gly Gln Thr 
                405                 410                 415     


Asn Pro Ile Ala Ala Lys Val Ser Arg Val Thr Gln Leu Ser Asp Gly 
            420                 425                 430         


Gln Leu Ser His Glu Thr Leu Leu Arg Glu Leu Leu Ser Asn Asp Ser 
        435                 440                 445             


Ser Asp Gly Lys Glu Ile Ala Arg Tyr Arg Val Ala Ser Asp Arg Leu 
    450                 455                 460                 


Arg Asp Lys Leu Ala Asn Leu Ala Val Glu Arg Leu Ser Pro Glu His 
465                 470                 475                 480 


Lys Ser Glu Ile Leu Arg Ala Lys Asn Asp Thr Pro Ala Leu Cys Lys 
                485                 490                 495     


Ala Arg Val Cys Ala Ala Leu Gly Leu Asn Pro Glu Met Ile Ala Trp 
            500                 505                 510         


Asp Lys Met Thr Pro Tyr Thr Glu Phe Leu Ala Thr Ala Tyr Leu Glu 
        515                 520                 525             


Lys Gly Gly Asp Arg Lys Val Ala Thr Leu Lys Pro Lys Asn Arg Pro 
    530                 535                 540                 


Glu Met Leu Arg Arg Asp Ile Lys Phe Lys Gly Thr Glu Gly Val Arg 
545                 550                 555                 560 


Ile Glu Val Ser Pro Glu Ala Ala Glu Ala Tyr Arg Glu Ala Gln Trp 
                565                 570                 575     


Asp Leu Gln Arg Thr Ser Pro Glu Tyr Leu Arg Leu Ser Thr Trp Lys 
            580                 585                 590         


Gln Glu Leu Thr Lys Arg Ile Leu Asn Gln Leu Arg His Lys Ala Ala 
        595                 600                 605             


Lys Ser Ser Gln Cys Glu Val Val Val Met Ala Phe Glu Asp Leu Asn 
    610                 615                 620                 


Ile Lys Met Met His Gly Asn Gly Lys Trp Ala Asp Gly Gly Trp Asp 
625                 630                 635                 640 


Ala Phe Phe Ile Lys Lys Arg Glu Asn Arg Trp Phe Met Gln Ala Phe 
                645                 650                 655     


His Lys Ser Leu Thr Glu Leu Gly Ala His Lys Gly Val Pro Thr Ile 
            660                 665                 670         


Glu Val Thr Pro His Arg Thr Ser Ile Thr Cys Thr Lys Cys Gly His 
        675                 680                 685             


Cys Asp Lys Ala Asn Arg Asp Gly Glu Arg Phe Ala Cys Gln Lys Cys 
    690                 695                 700                 


Gly Phe Val Ala His Ala Asp Leu Glu Ile Ala Thr Asp Asn Ile Glu 
705                 710                 715                 720 


Arg Val Ala Leu Thr Gly Lys Pro Met Pro Lys Pro Glu Ser Glu Arg 
                725                 730                 735     


Ser Gly Asp Ala Lys Lys Ser Val Gly Ala Arg Lys Ala Ala Phe Lys 
            740                 745                 750         


Pro Glu Glu Asp Ala Glu Ala Ala Glu 
        755                 760     


<210>  60
<211>  708
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  60

Met Ser Lys Thr Lys Glu Leu Asn Asp Tyr Gln Glu Ala Leu Ala Arg 
1               5                   10                  15      


Arg Leu Pro Gly Val Arg His Gln Lys Ser Val Arg Arg Ala Ala Arg 
            20                  25                  30          


Leu Val Tyr Asp Arg Gln Gly Glu Asp Ala Met Val Ala Phe Leu Asp 
        35                  40                  45              


Gly Lys Glu Val Asp Glu Pro Tyr Thr Leu Gln Pro Pro Ala Lys Cys 
    50                  55                  60                  


His Ile Leu Ala Val Ser Arg Pro Ile Glu Glu Trp Pro Ile Ala Arg 
65                  70                  75                  80  


Val Thr Met Ala Val Gln Glu His Val Tyr Ala Leu Pro Val His Glu 
                85                  90                  95      


Val Glu Lys Ser Arg Pro Glu Thr Thr Glu Gly Ser Arg Ser Ala Trp 
            100                 105                 110         


Phe Lys Asn Ser Gly Val Ser Asn His Gly Val Thr His Ala Gln Thr 
        115                 120                 125             


Leu Asn Ala Ile Leu Lys Asn Ala Tyr Asn Val Tyr Asn Gly Val Ile 
    130                 135                 140                 


Lys Lys Val Glu Asn Arg Asn Ala Lys Lys Arg Asp Ser Leu Ala Ala 
145                 150                 155                 160 


Lys Asn Lys Ser Arg Glu Arg Lys Gly Leu Pro His Phe Lys Ala Asp 
                165                 170                 175     


Pro Pro Glu Leu Ala Thr Asp Glu Gln Gly Tyr Leu Leu Gln Pro Pro 
            180                 185                 190         


Ser Pro Asn Ser Ser Val Tyr Leu Val Gln Gln His Leu Arg Thr Pro 
        195                 200                 205             


Gln Ile Asp Leu Pro Ser Gly Tyr Thr Gly Pro Val Val Asp Pro Arg 
    210                 215                 220                 


Ser Pro Ile Pro Ser Leu Ile Pro Ile Asp Arg Leu Ala Ile Pro Pro 
225                 230                 235                 240 


Gly Gln Pro Gly Tyr Val Pro Leu His Asp Arg Glu Lys Leu Thr Ser 
                245                 250                 255     


Asn Lys His Arg Arg Met Lys Leu Pro Lys Ser Leu Arg Ala Gln Gly 
            260                 265                 270         


Ala Leu Pro Val Cys Phe Arg Val Phe Asp Asp Trp Ala Val Val Asp 
        275                 280                 285             


Gly Arg Gly Leu Leu Arg His Ala Gln Tyr Arg Arg Leu Ala Pro Lys 
    290                 295                 300                 


Asn Val Ser Ile Ala Glu Leu Leu Glu Leu Tyr Thr Gly Asp Pro Val 
305                 310                 315                 320 


Ile Asp Ile Lys Arg Asn Leu Met Thr Phe Arg Phe Ala Glu Ala Val 
                325                 330                 335     


Val Glu Val Thr Ala Arg Lys Ile Val Glu Lys Tyr His Asn Lys Tyr 
            340                 345                 350         


Leu Leu Lys Leu Thr Glu Pro Lys Gly Lys Pro Val Arg Glu Ile Gly 
        355                 360                 365             


Leu Val Ser Ile Asp Leu Asn Val Gln Arg Leu Ile Ala Leu Ala Ile 
    370                 375                 380                 


Tyr Arg Val His Gln Thr Gly Glu Ser Gln Leu Ala Leu Ser Pro Cys 
385                 390                 395                 400 


Leu His Arg Glu Ile Leu Pro Ala Lys Gly Leu Gly Asp Phe Asp Lys 
                405                 410                 415     


Tyr Lys Ser Lys Phe Asn Gln Leu Thr Glu Glu Ile Leu Thr Ala Ala 
            420                 425                 430         


Val Gln Thr Leu Thr Ser Ala Gln Gln Glu Glu Tyr Gln Arg Tyr Val 
        435                 440                 445             


Glu Glu Ser Ser His Glu Ala Lys Ala Asp Leu Cys Leu Lys Tyr Ser 
    450                 455                 460                 


Ile Thr Pro His Glu Leu Ala Trp Asp Lys Met Thr Ser Ser Thr Gln 
465                 470                 475                 480 


Tyr Ile Ser Arg Trp Leu Arg Asp His Gly Trp Asn Ala Ser Asp Phe 
                485                 490                 495     


Thr Gln Ile Thr Lys Gly Arg Lys Lys Val Glu Arg Leu Trp Ser Asp 
            500                 505                 510         


Ser Arg Trp Ala Gln Glu Leu Lys Pro Lys Leu Ser Asn Glu Thr Arg 
        515                 520                 525             


Arg Lys Leu Glu Asp Ala Lys His Asp Leu Gln Arg Ala Asn Pro Glu 
    530                 535                 540                 


Trp Gln Arg Leu Ala Lys Arg Lys Gln Glu Tyr Ser Arg His Leu Ala 
545                 550                 555                 560 


Asn Thr Val Leu Ser Met Ala Arg Glu Tyr Thr Ala Cys Glu Thr Val 
                565                 570                 575     


Val Ile Ala Ile Glu Asn Leu Pro Met Lys Gly Gly Phe Val Asp Gly 
            580                 585                 590         


Asn Gly Ser Arg Glu Ser Gly Trp Asp Asn Phe Phe Thr His Lys Lys 
        595                 600                 605             


Glu Asn Arg Trp Met Ile Lys Asp Ile His Lys Ala Leu Ser Asp Leu 
    610                 615                 620                 


Ala Pro Asn Arg Gly Val His Val Leu Glu Val Asn Pro Gln Tyr Thr 
625                 630                 635                 640 


Ser Gln Thr Cys Pro Glu Cys Gly His Arg Asp Lys Ala Asn Arg Asp 
                645                 650                 655     


Pro Ile Gln Arg Glu Arg Phe Cys Cys Thr His Cys Gly Ala Gln Arg 
            660                 665                 670         


His Ala Asp Leu Glu Val Ala Thr His Asn Ile Ala Met Val Ala Thr 
        675                 680                 685             


Thr Gly Lys Ser Leu Thr Gly Lys Ser Leu Ala Pro Gln Arg Leu Gln 
    690                 695                 700                 


Glu Ala Ala Glu 
705             


<210>  61
<211>  661
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  61

Val Ala Phe Leu Asp Gly Lys Glu Val Asp Glu Pro Tyr Thr Leu Gln 
1               5                   10                  15      


Pro Pro Ala Lys Cys His Ile Leu Ala Val Ser Arg Pro Ile Glu Glu 
            20                  25                  30          


Trp Pro Ile Ala Arg Val Thr Met Ala Val Gln Glu His Val Tyr Ala 
        35                  40                  45              


Leu Pro Val His Glu Val Glu Lys Ser Arg Pro Glu Thr Thr Glu Gly 
    50                  55                  60                  


Ser Arg Ser Ala Trp Phe Lys Asn Ser Gly Val Ser Asn His Gly Val 
65                  70                  75                  80  


Thr His Ala Gln Thr Leu Asn Ala Ile Leu Lys Asn Ala Tyr Asn Val 
                85                  90                  95      


Tyr Asn Gly Val Ile Lys Lys Val Glu Asn Arg Asn Ala Lys Lys Arg 
            100                 105                 110         


Asp Ser Leu Ala Ala Lys Asn Lys Ser Arg Glu Arg Lys Gly Leu Pro 
        115                 120                 125             


His Phe Lys Ala Asp Pro Pro Glu Leu Ala Thr Asp Glu Gln Gly Tyr 
    130                 135                 140                 


Leu Leu Gln Pro Pro Ser Pro Asn Ser Ser Val Tyr Leu Val Gln Gln 
145                 150                 155                 160 


His Leu Arg Thr Pro Gln Ile Asp Leu Pro Ser Gly Tyr Thr Gly Pro 
                165                 170                 175     


Val Val Asp Pro Arg Ser Pro Ile Pro Ser Leu Ile Pro Ile Asp Arg 
            180                 185                 190         


Leu Ala Ile Pro Pro Gly Gln Pro Gly Tyr Val Pro Leu His Asp Arg 
        195                 200                 205             


Glu Lys Leu Thr Ser Asn Lys His Arg Arg Met Lys Leu Pro Lys Ser 
    210                 215                 220                 


Leu Arg Ala Gln Gly Ala Leu Pro Val Cys Phe Arg Val Phe Asp Asp 
225                 230                 235                 240 


Trp Ala Val Val Asp Gly Arg Gly Leu Leu Arg His Ala Gln Tyr Arg 
                245                 250                 255     


Arg Leu Ala Pro Lys Asn Val Ser Ile Ala Glu Leu Leu Glu Leu Tyr 
            260                 265                 270         


Thr Gly Asp Pro Val Ile Asp Ile Lys Arg Asn Leu Met Thr Phe Arg 
        275                 280                 285             


Phe Ala Glu Ala Val Val Glu Val Thr Ala Arg Lys Ile Val Glu Lys 
    290                 295                 300                 


Tyr His Asn Lys Tyr Leu Leu Lys Leu Thr Glu Pro Lys Gly Lys Pro 
305                 310                 315                 320 


Val Arg Glu Ile Gly Leu Val Ser Ile Asp Leu Asn Val Gln Arg Leu 
                325                 330                 335     


Ile Ala Leu Ala Ile Tyr Arg Val His Gln Thr Gly Glu Ser Gln Leu 
            340                 345                 350         


Ala Leu Ser Pro Cys Leu His Arg Glu Ile Leu Pro Ala Lys Gly Leu 
        355                 360                 365             


Gly Asp Phe Asp Lys Tyr Lys Ser Lys Phe Asn Gln Leu Thr Glu Glu 
    370                 375                 380                 


Ile Leu Thr Ala Ala Val Gln Thr Leu Thr Ser Ala Gln Gln Glu Glu 
385                 390                 395                 400 


Tyr Gln Arg Tyr Val Glu Glu Ser Ser His Glu Ala Lys Ala Asp Leu 
                405                 410                 415     


Cys Leu Lys Tyr Ser Ile Thr Pro His Glu Leu Ala Trp Asp Lys Met 
            420                 425                 430         


Thr Ser Ser Thr Gln Tyr Ile Ser Arg Trp Leu Arg Asp His Gly Trp 
        435                 440                 445             


Asn Ala Ser Asp Phe Thr Gln Ile Thr Lys Gly Arg Lys Lys Val Glu 
    450                 455                 460                 


Arg Leu Trp Ser Asp Ser Arg Trp Ala Gln Glu Leu Lys Pro Lys Leu 
465                 470                 475                 480 


Ser Asn Glu Thr Arg Arg Lys Leu Glu Asp Ala Lys His Asp Leu Gln 
                485                 490                 495     


Arg Ala Asn Pro Glu Trp Gln Arg Leu Ala Lys Arg Lys Gln Glu Tyr 
            500                 505                 510         


Ser Arg His Leu Ala Asn Thr Val Leu Ser Met Ala Arg Glu Tyr Thr 
        515                 520                 525             


Ala Cys Glu Thr Val Val Ile Ala Ile Glu Asn Leu Pro Met Lys Gly 
    530                 535                 540                 


Gly Phe Val Asp Gly Asn Gly Ser Arg Glu Ser Gly Trp Asp Asn Phe 
545                 550                 555                 560 


Phe Thr His Lys Lys Glu Asn Arg Trp Met Ile Lys Asp Ile His Lys 
                565                 570                 575     


Ala Leu Ser Asp Leu Ala Pro Asn Arg Gly Val His Val Leu Glu Val 
            580                 585                 590         


Asn Pro Gln Tyr Thr Ser Gln Thr Cys Pro Glu Cys Gly His Arg Asp 
        595                 600                 605             


Lys Ala Asn Arg Asp Pro Ile Gln Arg Glu Arg Phe Cys Cys Thr His 
    610                 615                 620                 


Cys Gly Ala Gln Arg His Ala Asp Leu Glu Val Ala Thr His Asn Ile 
625                 630                 635                 640 


Ala Met Val Ala Thr Thr Gly Lys Ser Leu Thr Gly Lys Ser Leu Ala 
                645                 650                 655     


Pro Gln Arg Leu Gln 
            660     


<210>  62
<211>  845
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  62

Met Ile Lys Lys Pro Ser Asn Arg His Ala Leu Pro Lys Val Ile Ile 
1               5                   10                  15      


Ser Lys Val Asp Asn Gln Asn Ile Leu Glu Phe Lys Ile Lys Tyr Lys 
            20                  25                  30          


Lys Leu Ser Arg Leu Asp Arg Val Glu Ile Lys Thr Met His Tyr Asp 
        35                  40                  45              


Asp Arg Ala Ile Val Phe Asp Glu Val Ile Ile Asn Gly Gly Leu Ile 
    50                  55                  60                  


Asp Val Glu Tyr Arg Asp Asn His Lys Thr Ile Phe Val Lys Val Gly 
65                  70                  75                  80  


Asp Lys Ser Tyr Ser Ile Ser Gly Gln Lys Val Gly Gly Lys Glu Arg 
                85                  90                  95      


Leu Leu Glu Asn Arg Ile Ser Gln Thr Lys Val Gln Leu Glu Leu Lys 
            100                 105                 110         


Asp Glu Ala Thr Asn Arg Val Ser Lys Thr Glu Arg Glu Leu Ile Val 
        115                 120                 125             


Asp Asp Asn Ile Lys Leu Tyr Ser Gln Ile Val Gly Arg Asp Val Lys 
    130                 135                 140                 


Thr Thr Lys Asp Ile Tyr Leu Ile Lys Arg Phe Leu Gly Tyr Arg Ser 
145                 150                 155                 160 


Asp Leu Leu Phe Tyr Tyr Gly Phe Val Asn Asn Phe Phe His Val Ala 
                165                 170                 175     


Asn Asn Arg Pro Glu Phe Trp Lys Ile Asp Phe Asn Asp Asn Arg Asn 
            180                 185                 190         


Ser Lys Leu Ile Glu Tyr Phe Ile Phe Thr Ile Asn Asp His Leu Lys 
        195                 200                 205             


Asn Asp Glu Asn Tyr Leu Lys Asp Tyr Ile Ser Asp Arg Gly Gln Ile 
    210                 215                 220                 


Val Asp Asp Leu Glu Asn Ile Lys His Ile Phe Ser Ala Leu Arg His 
225                 230                 235                 240 


Gly Leu Met His Phe Asp Tyr Asp Phe Phe Glu Ala Leu Phe Asn Gly 
                245                 250                 255     


Glu Asp Ile Asp Ile Lys Met Asp Asn Gln Gly Asn Thr Gln Pro Leu 
            260                 265                 270         


Ser Ser Leu Asn Ile Lys Phe Leu Asp Ile Met Ile Asp Lys Leu Asp 
        275                 280                 285             


Lys Leu Asn Ile Asp Thr Lys Lys Glu Phe Ile Asp Ala Glu Lys Ile 
    290                 295                 300                 


Thr Ile Phe Gly Glu Glu Leu Ser Leu Ala Lys Leu Tyr Arg Phe Tyr 
305                 310                 315                 320 


Ala His Thr Ala Ile Asn Arg Val Ala Phe Asn Lys Leu Ile Asn Ser 
                325                 330                 335     


Phe Ile Ile Glu Asn Gly Val Glu Asn Gln Ser Leu Lys Glu Tyr Phe 
            340                 345                 350         


Asn Gln Gln Ala Gly Gly Ile Ala Tyr Glu Ile Asp Ile His Gln Asn 
        355                 360                 365             


Arg Glu Tyr Lys Asn Leu Tyr Asn Glu His Lys Lys Leu Val Ser Arg 
    370                 375                 380                 


Val Leu Ser Ile Ser Asp Gly Gln Glu Ile Ala Thr Leu Asn Gln Lys 
385                 390                 395                 400 


Ile Val Glu Leu Lys Glu Gln Met Lys Gln Ile Thr Lys Ile Asn Ser 
                405                 410                 415     


Ile Lys Arg Leu Glu Tyr Lys Leu Arg Leu Ala Phe Gly Phe Ile Tyr 
            420                 425                 430         


Thr Glu Tyr Lys Asn Tyr Glu Glu Phe Lys Asn Ser Phe Asp Thr Asp 
        435                 440                 445             


Ile Lys Asn Gly Arg Phe Thr Pro Lys Asp Glu Asp Gly Asn Lys Arg 
    450                 455                 460                 


Ala Phe Asp Ser Arg Glu Leu Glu His Leu Lys Gly Tyr Tyr Lys Ala 
465                 470                 475                 480 


Thr Leu Gln Thr Gln Lys Pro Gln Thr Asp Glu Lys Met Glu Glu Val 
                485                 490                 495     


Ser Lys Arg Val Asp Arg Leu Ser Leu Lys Ser Leu Ile Gly Asp Asp 
            500                 505                 510         


Thr Leu Leu Lys Phe Ile Leu Leu Met Phe Thr Phe Met Pro Gln Glu 
        515                 520                 525             


Leu Lys Gly Glu Phe Leu Gly Phe Ile Lys Lys Tyr Tyr His Asp Thr 
    530                 535                 540                 


Lys His Ile Asp Gln Asp Thr Ile Ser Asp Ser Asp Asp Thr Ile Glu 
545                 550                 555                 560 


Glu Gly Leu Ser Ile Gly Leu Lys Leu Lys Ile Leu Asp Lys Asn Ile 
                565                 570                 575     


Arg Ser Leu Ser Ile Leu Lys His Ser Leu Ser Phe Gln Thr Lys Tyr 
            580                 585                 590         


Asn Lys Lys Asp Arg Ser Tyr Tyr Glu Asp Gly Asn Ile His Gly Lys 
        595                 600                 605             


Phe Phe Lys Lys Leu Gly Ile Ser His Asn Gln Glu Glu Phe Asn Lys 
    610                 615                 620                 


Ser Val Tyr Ala Pro Leu Phe Arg Tyr Tyr Ser Ala Leu Tyr Lys Leu 
625                 630                 635                 640 


Ile Asn Asp Phe Glu Ile Tyr Thr Leu Ser Leu His Ile Val Gly Asn 
                645                 650                 655     


Glu Thr Leu Ser Asp Gln Val Asn Lys Pro Gln Phe Leu Ser Gly Arg 
            660                 665                 670         


Tyr Phe Asn Phe Arg Lys Leu Leu Thr Gln Ser Tyr Asn Ile Ser Asn 
        675                 680                 685             


Asn Ser Thr His Ser Val Ile Phe Asn Ala Val Ile Asn Met Arg Asn 
    690                 695                 700                 


Asp Ile Ser His Leu Ser Tyr Glu Pro Leu Leu Asp Cys Pro Leu Asn 
705                 710                 715                 720 


Gly Lys Lys Ser Tyr Lys Arg Lys Ile Arg Asn Gln Phe Arg Thr Ile 
                725                 730                 735     


Asn Ile Lys Pro Leu Val Glu Ser Arg Lys Met Ile Ile Asp Phe Ile 
            740                 745                 750         


Thr Leu Gln Thr Asp Met Gln Lys Val Leu Gly Cys Asp Ala Val Asn 
        755                 760                 765             


Asp Phe Thr Met Lys Ile Val Gln Leu Arg Thr Arg Leu Lys Ala Tyr 
    770                 775                 780                 


Ala Asn Lys Glu Gln Thr Ile Glu Lys Met Ile Thr Glu Ala Lys Thr 
785                 790                 795                 800 


Pro Asn Asp Phe Tyr Asn Ile Tyr Lys Val Lys Gly Val Glu Ala Ile 
                805                 810                 815     


Asn Lys Tyr Leu Leu Glu Val Ile Gly Glu Thr Gln Val Glu Lys Glu 
            820                 825                 830         


Ile Arg Glu Glu Ile Glu Arg Gly Asn Ile Ala Asn Ser 
        835                 840                 845 


<210>  63
<211>  802
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  63

Met Leu Lys Lys Pro Ser Asn Arg Tyr Ala Leu Pro Lys Val Ile Leu 
1               5                   10                  15      


Ser Thr Val Asp His Glu Lys Ile Leu Glu Phe Lys Val Lys Tyr Glu 
            20                  25                  30          


Lys Leu Ala Arg Leu Asp Arg Leu Val Val Glu Arg Met His Phe Asp 
        35                  40                  45              


Gly Glu Ser Val Val Phe Asp Glu Val Ile Ala Asn Ser Gly Asp Leu 
    50                  55                  60                  


Glu Ile Ala Tyr Gln Asp Asp His Arg Lys Leu Leu Ile Gln Ala Ala 
65                  70                  75                  80  


Gly Lys Ser Tyr Thr Ile Thr Gly Lys Lys Val Gly Gly Lys Lys Arg 
                85                  90                  95      


Lys Leu Glu Glu Arg Ile Ser Arg Ala Lys Ile Gln Leu Thr Leu Thr 
            100                 105                 110         


Asp Gly Gln Glu Asp Gln His Arg Arg Ile Arg Ala Thr Val Thr Glu 
        115                 120                 125             


Lys Ala Leu Leu Glu Pro Lys Glu Asp Arg Asp Ile Tyr Ser Lys Ile 
    130                 135                 140                 


Ser Asp Arg Lys Ile Lys Thr Ser Lys Glu Ile Tyr Leu Val Lys Arg 
145                 150                 155                 160 


Phe Leu Ser Tyr Arg Ser Asp Leu Leu Phe Tyr Tyr Phe Phe Val Asp 
                165                 170                 175     


Asn Phe Phe Lys Val Gly Asn Asn Lys Gln Glu Leu Trp Lys Ile Lys 
            180                 185                 190         


Phe Gln Asn Gln Pro Glu Leu Ile Glu Tyr Phe Arg Phe Ile Ile Asn 
        195                 200                 205             


Asp Arg Phe Lys Asn Ala Lys Asn Asp Lys Phe Asp Asn Tyr Leu Lys 
    210                 215                 220                 


Asn Asp Lys Ala Ile Gln Glu Asp Leu Glu Lys Ile Gln Lys Val Phe 
225                 230                 235                 240 


Glu Lys Leu Arg His Ala Leu Met His Tyr Asp Tyr Gly Phe Phe Glu 
                245                 250                 255     


Lys Leu Phe Gly Gly Glu Asp Gln Gly Phe Asp Leu Asp Ile Ala Phe 
            260                 265                 270         


Leu Asp Asn Phe Val Lys Lys Ile Asp Lys Leu Asn Ile Asp Thr Lys 
        275                 280                 285             


Lys Glu Phe Val Asp Asp Glu Lys Ile Lys Ile Phe Gly Glu Asp Leu 
    290                 295                 300                 


Asn Leu Ala Asp Leu Tyr Lys Leu Tyr Ala Ser Ile Ser Ile Asn Arg 
305                 310                 315                 320 


Val Gly Phe Asn Arg Val Val Asn Glu Met Ile Ile Lys Asp Gly Ile 
                325                 330                 335     


Glu Lys Ser Glu Leu Lys Arg Ala Phe Glu Lys Lys Leu Asp Lys Thr 
            340                 345                 350         


Tyr Ala Leu Asp Ile His Ser Asp Pro Ser Tyr Lys Lys Leu Tyr Asn 
        355                 360                 365             


Glu His Lys Arg Leu Val Thr Glu Val Ser Thr Tyr Thr Asp Gly Asn 
    370                 375                 380                 


Lys Ile Lys Glu Gly Asn Gln Lys Ile Ala Lys Leu Lys Tyr Glu Met 
385                 390                 395                 400 


Lys Glu Ile Thr Lys Lys Asn Ala Leu Val Arg Leu Glu Cys Lys Met 
                405                 410                 415     


Arg Leu Ala Phe Gly Leu Ile Tyr Gly Arg Tyr Asp Thr His Glu Ala 
            420                 425                 430         


Phe Lys Asn Gly Phe Asp Thr Asp Leu Lys Arg Gly Glu Phe Ala Gln 
        435                 440                 445             


Ile Gly Ser Glu Glu Ala Ile Gly Tyr Phe Asn Thr Thr Phe Glu Lys 
    450                 455                 460                 


Ser Lys Pro Lys Ser Lys Glu Glu Ile Lys Lys Ile Ala Arg Gln Ile 
465                 470                 475                 480 


Asp Asn Leu Ser Leu Ser Thr Leu Ile Glu Asp Asp Pro Leu Met Lys 
                485                 490                 495     


Phe Ile Val Leu Met Phe Leu Phe Val Pro Arg Glu Leu Lys Gly Glu 
            500                 505                 510         


Phe Leu Gly Phe Trp Arg Lys Tyr Tyr His Asp Ile His Ser Ile Asp 
        515                 520                 525             


Ser Asp Ala Lys Ser Asp Glu Met Pro Asp Glu Val Ser Leu Ser Leu 
    530                 535                 540                 


Lys Leu Lys Ile Leu Thr Arg Asn Ile Arg Arg Leu Asn Leu Phe Glu 
545                 550                 555                 560 


Tyr Ser Leu Ser Glu Lys Ile Lys Tyr Ser Pro Lys Asn Thr Gln Phe 
                565                 570                 575     


Tyr Thr Asp Lys Ser Pro Tyr Gln Lys Val Tyr Lys Arg Leu Lys Ile 
            580                 585                 590         


Ser His Asn Lys Glu Glu Phe Asp Lys Thr Leu Leu Val Pro Leu Phe 
        595                 600                 605             


Arg Tyr Tyr Ser Ile Leu Phe Lys Leu Ile Asn Asp Phe Glu Ile Tyr 
    610                 615                 620                 


Ser Leu Ala Lys Ala Asn Pro Asp Ala Ser Ser Leu Ser Glu Leu Thr 
625                 630                 635                 640 


Lys Thr Lys His Gly Phe Arg Gly His Tyr Asn Phe Thr Thr Leu Met 
                645                 650                 655     


Met Asp Ala His Lys Val Ser Gln Gly Asp Ser Lys Lys His Phe Gly 
            660                 665                 670         


Ile Arg Gly Glu Ile Ala His Ile Asn Thr Lys Asp Leu Ile Tyr Asp 
        675                 680                 685             


Pro Leu Phe Arg Lys Ser Lys Met Ala Gln Gln Arg Asn Asp Val Ile 
    690                 695                 700                 


Asp Phe Val Leu Lys Tyr Glu Lys Glu Ile Lys Ala Val Leu Gly Tyr 
705                 710                 715                 720 


Asp Ala Ile Asn Asp Phe Arg Met Lys Val Val Gln Leu Arg Thr Lys 
                725                 730                 735     


Leu Lys Val Tyr Ser Asp Lys Thr Gln Thr Ile Glu Lys Leu Leu Asn 
            740                 745                 750         


Glu Val Glu Ala Pro Asp Asp Phe Tyr Val Leu Tyr Lys Val Lys Gly 
        755                 760                 765             


Val Glu Ala Ile Asn Lys Tyr Leu Leu Glu Ile Val Ser Val Thr Gln 
    770                 775                 780                 


Ala Glu Glu Glu Ile Glu Arg Lys Ile Ile Thr Gly Asn Lys Arg Tyr 
785                 790                 795                 800 


Asn Thr 
        


<210>  64
<211>  1281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  64

Met Ile Lys Ser Tyr Asp Asp Phe Thr Lys Leu Tyr Ser Leu Gln Lys 
1               5                   10                  15      


Thr Leu Arg Phe Glu Leu Lys Pro Ile Gly Lys Thr Leu Glu His Ile 
            20                  25                  30          


Lys Lys Ser Glu Ile Ile Glu Ser Asp Glu Thr Leu Glu Glu Gln Tyr 
        35                  40                  45              


Ala Ile Val Lys Asn Ile Ile Asp Arg Phe His Arg Lys His Ile Asp 
    50                  55                  60                  


Glu Ala Leu Ser Leu Val Asp Phe Thr Lys His Leu Asp Thr Phe Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Leu Tyr Leu Lys Arg Gly Lys Thr Asp Arg Glu Lys 
                85                  90                  95      


Lys Glu Leu Glu Glu Leu Ser Ala Asp Leu Arg Lys Leu Ile Val Ser 
            100                 105                 110         


Tyr Leu Lys Gly Asn Val Lys Gln Lys Thr Gln His Asn Leu Asn Pro 
        115                 120                 125             


Ile Lys Glu Arg Phe Glu Ile Leu Phe Gly Lys Glu Leu Phe Thr Asn 
    130                 135                 140                 


Glu Glu Phe Phe Thr Leu Ala Glu Asn Lys Glu Glu Lys Lys Ala Ile 
145                 150                 155                 160 


Gln Ala Phe Lys Gly Phe Thr Thr Tyr Phe Lys Gly Phe Gln Glu Asn 
                165                 170                 175     


Arg Lys Asn Met Tyr Ser Glu Glu Asp Lys Ser Thr Ala Ile Ala Tyr 
            180                 185                 190         


Arg Ile Ile Asn Glu Asn Met Pro Leu Phe Ile Glu Asn Ile Ala Arg 
        195                 200                 205             


Phe Gln Lys Val Leu Asp Val Ile Glu Lys Thr Lys Leu Thr Glu Leu 
    210                 215                 220                 


Lys Gln Asn Leu Lys Thr Glu Leu Lys Gly His Ser Val Ser Asp Ile 
225                 230                 235                 240 


Phe Arg Ile Glu Tyr Phe Asn Asn Val Leu Thr Gln Glu Gly Ile Ser 
                245                 250                 255     


Arg Tyr Asn Thr Ile Ile Gly Gly Lys Thr Thr Thr Glu Gly Val Lys 
            260                 265                 270         


Ile Gln Gly Leu Asn Glu Ile Ile Asn Leu His Asn Gln Gln Ser Lys 
        275                 280                 285             


Asp Val Lys Leu Pro Ile Leu Lys Pro Leu His Lys Gln Ile Leu Ser 
    290                 295                 300                 


Glu Glu Tyr Ser Thr Ser Phe Lys Ile Lys Ala Phe Glu Asn Asp Asn 
305                 310                 315                 320 


Glu Val Leu Lys Ala Ile Asp Thr Phe Trp Asn Glu His Ile Glu Lys 
                325                 330                 335     


Ser Ile His Pro Val Thr Gly Lys Arg Phe Asn Ile Leu Leu Lys Ile 
            340                 345                 350         


Glu Asn Leu Cys Lys Lys Leu Glu Lys Tyr Lys Asp Lys Glu Ile Glu 
        355                 360                 365             


Lys Leu Phe Ile Glu Arg Lys Asn Leu Ser Thr Val Ser His Gln Val 
    370                 375                 380                 


Tyr Gly Gln Trp Asn Ile Ile Arg Asp Ala Leu Arg Met His Leu Glu 
385                 390                 395                 400 


Met Asn Asn Lys Asn Ile Lys Glu Lys Asp Ile Asp Lys Tyr Leu Asp 
                405                 410                 415     


Asn Asp Ala Phe Ala Trp Lys Glu Ile Lys Asp Ser Ile Lys Ile Tyr 
            420                 425                 430         


Lys Glu His Val Glu Asp Ala Lys Glu Leu Asp Glu Asn Gly Ile Val 
        435                 440                 445             


Lys Tyr Phe Ser Ser Met Ser Ile Asn Glu Glu Asp Asp Glu Lys Glu 
    450                 455                 460                 


Tyr Ser Ile Ser Leu Ile Lys Asn Ile Asn Glu Lys Tyr Asn Asn Val 
465                 470                 475                 480 


Lys Ser Ile Leu Glu Glu Asp Arg Thr Gly Lys Ser Asp Leu His Gln 
                485                 490                 495     


Asp Lys Glu Lys Val Ala Ile Ile Lys Glu Phe Leu Asp Ser Leu Lys 
            500                 505                 510         


Gln Leu Gln Trp Phe Leu Lys Leu Leu Tyr Val Thr Val Pro Leu Asp 
        515                 520                 525             


Glu Lys Asp Tyr Glu Phe Tyr Asn Glu Leu Glu Val Tyr Tyr Glu Ala 
    530                 535                 540                 


Leu Leu Pro Leu Asn Ser Leu Tyr Asn Lys Val Arg Asn Tyr Met Thr 
545                 550                 555                 560 


Arg Lys Pro Tyr Ser Val Glu Lys Phe Lys Leu Asn Phe Tyr Ser Pro 
                565                 570                 575     


Thr Leu Leu Asp Gly Trp Asp Lys Asn Lys Glu Thr Ala Asn Leu Ser 
            580                 585                 590         


Ile Ile Leu Lys Lys Asn Gly Lys Tyr Tyr Leu Gly Ile Met Asn Lys 
        595                 600                 605             


Glu Asn Asn Thr Ile Phe Glu Asn Phe Pro Lys Ser Lys Ser Asn Asp 
    610                 615                 620                 


Tyr Tyr Glu Lys Met Ile Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
625                 630                 635                 640 


Leu Pro Lys Val Phe Phe Ser Lys Lys Gly Leu Glu Tyr Tyr Lys Pro 
                645                 650                 655     


Ser Lys Glu Ile Leu Arg Ile Tyr Glu Lys Gly Glu Phe Lys Lys Asp 
            660                 665                 670         


Lys Ser Gly Asn Phe Lys Lys Glu Ser Leu His Thr Leu Ile Asp Phe 
        675                 680                 685             


Tyr Lys Glu Ala Ile Ala Lys Asn Glu Asp Trp Lys Ile Phe Lys Phe 
    690                 695                 700                 


Lys Phe Lys Asn Thr Arg Glu Tyr Glu Asp Ile Ser Gln Phe Tyr Arg 
705                 710                 715                 720 


Asp Val Glu Glu Gln Gly Tyr Leu Ile Ile Phe Glu Lys Val Asp Ala 
                725                 730                 735     


Asn Tyr Val Asp Lys Leu Val Glu Glu Gly Glu Leu Tyr Leu Phe Gln 
            740                 745                 750         


Ile Tyr Asn Lys Asp Phe Ser Glu Asn Lys Lys Ser Lys Gly Asn Pro 
        755                 760                 765             


Asn Leu His Thr Ile Tyr Trp Glu Ser Leu Phe Asp Asn Gln Asn Leu 
    770                 775                 780                 


Lys Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Val Phe Tyr Arg 
785                 790                 795                 800 


Lys Lys Ser Ile Asp Tyr Pro Glu Glu Ile Tyr Asn Asn Gly His His 
                805                 810                 815     


Lys Glu Glu Leu Asn Gly Lys Phe Asn Tyr Pro Ile Ile Lys Asp Arg 
            820                 825                 830         


Arg Tyr Thr Gln Asp Lys Phe Leu Phe His Val Pro Ile Thr Met Asn 
        835                 840                 845             


Phe Ile Ser Lys Glu Glu Lys Arg Val Asn Gln Leu Ala Cys Glu Tyr 
    850                 855                 860                 


Leu Ser Thr Thr Lys Glu Asp Val His Ile Ile Gly Ile Asp Arg Gly 
865                 870                 875                 880 


Glu Arg His Leu Leu Tyr Leu Ser Leu Ile Asp Lys Glu Gly Asn Ile 
                885                 890                 895     


Lys Lys Gln Leu Ser Leu Asn Thr Ile Lys Asn Glu Asn Tyr Asp Lys 
            900                 905                 910         


Glu Ile Asp Tyr Arg Val Lys Leu Asp Glu Lys Glu Lys Lys Arg Asp 
        915                 920                 925             


Glu Ala Arg Lys Asn Trp Asp Val Ile Glu Asn Ile Lys Glu Leu Lys 
    930                 935                 940                 


Glu Gly Tyr Met Ser Gln Val Ile His Ile Ile Ala Lys Met Met Ala 
945                 950                 955                 960 


Glu Glu Lys Ala Ile Leu Ile Met Glu Asp Leu Asn Ile Gly Phe Lys 
                965                 970                 975     


Arg Gly Arg Phe Lys Val Glu Lys Gln Val Tyr Gln Lys Phe Glu Lys 
            980                 985                 990         


Met Met Ile Asp Lys Leu Asn Tyr  Leu Val Phe Lys Asn  Lys Glu Pro 
        995                 1000                 1005             


Leu Glu  Pro Gly Gly Ser Leu  Asn Ala Tyr Gln Leu  Thr Ser Lys 
    1010                 1015                 1020             


Phe Asp  Ser Phe Lys Lys Leu  Gly Lys Gln Ser Gly  Phe Ile Phe 
    1025                 1030                 1035             


Tyr Val  Pro Ser Ala Tyr Thr  Ser Lys Ile Asp Pro  Thr Thr Gly 
    1040                 1045                 1050             


Phe Tyr  Asn Phe Ile Arg Val  Asp Val Pro Asn Leu  Glu Lys Gly 
    1055                 1060                 1065             


Lys Glu  Phe Phe Ser Lys Phe  Glu Lys Ile Ile Tyr  Asn Thr Lys 
    1070                 1075                 1080             


Glu Asp  Tyr Phe Glu Phe His  Cys Lys Tyr Gly Lys  Phe Val Pro 
    1085                 1090                 1095             


Glu Pro  Lys Asn Lys Asp Asn  Asp Arg Lys Thr Lys  Glu Ser Leu 
    1100                 1105                 1110             


Thr Tyr  Tyr Asn Ala Ile Lys  Asp Thr Val Trp Val  Val Cys Ser 
    1115                 1120                 1125             


Thr His  His Glu Arg Tyr Lys  Ile Val Arg Asn Lys  Ala Gly Tyr 
    1130                 1135                 1140             


Tyr Glu  Ser Gln Pro Val Asp  Val Thr Lys Asn Leu  Arg Asp Ile 
    1145                 1150                 1155             


Phe Ser  Glu Ala Asn Ile Asn  Tyr Ser Asp Gly Lys  Asp Ile Lys 
    1160                 1165                 1170             


Pro Ile  Ile Ile Glu Ser Asn  Asn Ala Lys Leu Leu  Lys Ser Ile 
    1175                 1180                 1185             


Ala Glu  Gln Leu Lys Leu Ile  Leu Ala Met Arg Tyr  Asn Asn Gly 
    1190                 1195                 1200             


Lys His  Asp Asp Asp Glu Lys  Asp Tyr Ile Leu Ser  Pro Val Lys 
    1205                 1210                 1215             


Asn Lys  Gln Gly Lys Phe Phe  Cys Ser Leu Asp Gly  Asp Gln Ser 
    1220                 1225                 1230             


Leu Pro  Ile Asn Ala Asp Ala  Asn Gly Ala Tyr Asn  Ile Ala Leu 
    1235                 1240                 1245             


Lys Gly  Leu Leu Leu Ile Glu  Lys Ile Lys Lys Gln  Gln Gly Lys 
    1250                 1255                 1260             


Ala Lys  Asp Leu Tyr Ile Ser  Asn Leu Glu Trp Phe  Met Phe Met 
    1265                 1270                 1275             


Met Ser  Arg 
    1280     


<210>  65
<211>  1281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  65

Met Ile Lys Ser Tyr Asp Asp Phe Thr Lys Leu Tyr Ser Leu Gln Lys 
1               5                   10                  15      


Thr Leu Arg Phe Glu Leu Lys Pro Ile Gly Lys Thr Leu Glu His Ile 
            20                  25                  30          


Lys Lys Ser Glu Ile Ile Glu Ser Asp Glu Thr Leu Glu Glu Gln Tyr 
        35                  40                  45              


Ala Ile Val Lys Asn Ile Ile Asp Arg Phe His Arg Lys His Ile Asp 
    50                  55                  60                  


Glu Ala Leu Ser Leu Val Asp Phe Thr Lys His Leu Asp Thr Phe Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Leu Tyr Leu Lys Arg Gly Lys Thr Asp Arg Glu Lys 
                85                  90                  95      


Lys Glu Leu Glu Glu Leu Ser Ala Asp Leu Arg Lys Leu Ile Val Ser 
            100                 105                 110         


Tyr Leu Lys Gly Asn Val Lys Gln Lys Thr Gln His Asn Leu Asn Pro 
        115                 120                 125             


Ile Lys Glu Arg Phe Glu Ile Leu Phe Gly Lys Glu Leu Phe Thr Asn 
    130                 135                 140                 


Glu Glu Phe Phe Thr Leu Ala Glu Asn Lys Glu Glu Lys Lys Ala Ile 
145                 150                 155                 160 


Gln Ala Phe Lys Gly Phe Thr Thr Tyr Phe Lys Gly Phe Gln Glu Asn 
                165                 170                 175     


Arg Lys Asn Met Tyr Ser Glu Glu Asp Lys Ser Thr Ala Ile Ala Tyr 
            180                 185                 190         


Arg Ile Ile Asn Glu Asn Met Pro Leu Phe Ile Glu Asn Ile Ala Arg 
        195                 200                 205             


Phe Gln Lys Val Leu Asp Val Ile Glu Lys Thr Lys Leu Thr Glu Leu 
    210                 215                 220                 


Lys Gln Asn Leu Lys Thr Glu Leu Lys Gly His Ser Val Ser Asp Ile 
225                 230                 235                 240 


Phe Arg Ile Glu Tyr Phe Asn Asn Val Leu Thr Gln Glu Gly Ile Ser 
                245                 250                 255     


Arg Tyr Asn Thr Ile Ile Gly Gly Lys Thr Thr Thr Glu Gly Val Lys 
            260                 265                 270         


Ile Gln Gly Leu Asn Glu Ile Ile Asn Leu His Asn Gln Gln Ser Lys 
        275                 280                 285             


Asp Val Lys Leu Pro Ile Leu Lys Pro Leu His Lys Gln Ile Leu Ser 
    290                 295                 300                 


Glu Glu Tyr Ser Thr Ser Phe Lys Ile Lys Ala Phe Glu Asn Asp Asn 
305                 310                 315                 320 


Glu Val Leu Lys Ala Ile Asp Thr Phe Trp Asn Glu His Ile Glu Lys 
                325                 330                 335     


Ser Ile His Pro Val Thr Gly Lys Arg Phe Asn Ile Leu Leu Lys Ile 
            340                 345                 350         


Glu Asn Leu Cys Lys Lys Leu Glu Lys Tyr Lys Asp Lys Glu Ile Glu 
        355                 360                 365             


Lys Leu Phe Ile Glu Arg Lys Asn Leu Ser Thr Val Ser His Gln Val 
    370                 375                 380                 


Tyr Gly Gln Trp Asn Ile Ile Arg Asp Ala Leu Arg Met His Leu Glu 
385                 390                 395                 400 


Met Asn Asn Lys Asn Ile Lys Glu Lys Asp Ile Asp Lys Tyr Leu Asp 
                405                 410                 415     


Asn Asp Ala Phe Ala Trp Lys Glu Ile Lys Asp Ser Ile Lys Ile Tyr 
            420                 425                 430         


Lys Glu His Val Glu Asp Ala Lys Glu Leu Asp Glu Asn Gly Ile Val 
        435                 440                 445             


Lys Tyr Phe Ser Ser Met Ser Ile Asn Glu Glu Asp Asp Glu Lys Glu 
    450                 455                 460                 


Tyr Ser Ile Ser Leu Ile Lys Asn Ile Asn Glu Lys Tyr Asn Asn Val 
465                 470                 475                 480 


Lys Ser Ile Leu Glu Glu Asp Arg Thr Gly Lys Ser Asp Leu His Gln 
                485                 490                 495     


Asp Lys Glu Lys Val Ala Ile Ile Lys Glu Phe Leu Asp Ser Leu Lys 
            500                 505                 510         


Gln Leu Gln Trp Phe Leu Lys Leu Leu Tyr Val Thr Val Pro Leu Asp 
        515                 520                 525             


Glu Lys Asp Tyr Glu Phe Tyr Asn Glu Leu Glu Val Tyr Tyr Glu Ala 
    530                 535                 540                 


Leu Leu Pro Leu Asn Ser Leu Tyr Asn Lys Val Arg Asn Tyr Met Thr 
545                 550                 555                 560 


Arg Lys Pro Tyr Ser Val Glu Lys Phe Lys Leu Asn Phe Tyr Ser Pro 
                565                 570                 575     


Thr Leu Leu Asp Gly Trp Asp Lys Asn Lys Glu Thr Ala Asn Leu Ser 
            580                 585                 590         


Ile Ile Leu Lys Lys Asn Gly Lys Tyr Tyr Leu Gly Ile Met Asn Lys 
        595                 600                 605             


Glu Asn Asn Thr Ile Phe Glu Asn Phe Pro Lys Ser Lys Ser Asn Asp 
    610                 615                 620                 


Tyr Tyr Glu Lys Met Ile Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
625                 630                 635                 640 


Leu Pro Lys Val Phe Phe Ser Lys Lys Gly Leu Glu Tyr Tyr Lys Pro 
                645                 650                 655     


Ser Lys Glu Ile Leu Arg Ile Tyr Glu Lys Gly Glu Phe Lys Lys Asp 
            660                 665                 670         


Lys Ser Gly Asn Phe Lys Lys Glu Ser Leu His Thr Leu Ile Asp Phe 
        675                 680                 685             


Tyr Lys Glu Ala Ile Ala Lys Asn Glu Asp Trp Lys Ile Phe Lys Phe 
    690                 695                 700                 


Lys Phe Lys Asn Thr Arg Glu Tyr Glu Asp Ile Ser Gln Phe Tyr Arg 
705                 710                 715                 720 


Asp Val Glu Glu Gln Gly Tyr Leu Ile Ile Phe Glu Lys Val Asp Ala 
                725                 730                 735     


Asn Tyr Val Asp Lys Leu Val Glu Glu Gly Glu Leu Tyr Leu Phe Gln 
            740                 745                 750         


Ile Tyr Asn Lys Asp Phe Ser Glu Asn Lys Lys Ser Lys Gly Asn Pro 
        755                 760                 765             


Asn Leu His Thr Ile Tyr Trp Glu Ser Leu Phe Asp Asn Gln Asn Leu 
    770                 775                 780                 


Lys Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Val Phe Tyr Arg 
785                 790                 795                 800 


Lys Lys Ser Ile Asp Tyr Pro Glu Glu Ile Tyr Asn Asn Gly His His 
                805                 810                 815     


Lys Glu Glu Leu Asn Gly Lys Phe Asn Tyr Pro Ile Ile Lys Asp Arg 
            820                 825                 830         


Arg Tyr Thr Gln Asp Lys Phe Leu Phe His Val Pro Ile Thr Met Asn 
        835                 840                 845             


Phe Ile Ser Lys Glu Glu Lys Arg Val Asn Gln Leu Ala Cys Glu Tyr 
    850                 855                 860                 


Leu Ser Thr Thr Lys Glu Asp Val His Ile Ile Gly Ile Asp Arg Gly 
865                 870                 875                 880 


Glu Arg His Leu Leu Tyr Leu Ser Leu Ile Asp Lys Glu Gly Asn Ile 
                885                 890                 895     


Lys Lys Gln Leu Ser Leu Asn Thr Ile Lys Asn Glu Asn Tyr Asp Lys 
            900                 905                 910         


Glu Ile Asp Tyr Arg Val Lys Leu Asp Glu Lys Glu Lys Lys Arg Asp 
        915                 920                 925             


Glu Ala Arg Lys Asn Trp Asp Val Ile Glu Asn Ile Lys Glu Leu Lys 
    930                 935                 940                 


Glu Gly Tyr Met Ser Gln Val Ile His Ile Ile Ala Lys Met Met Ala 
945                 950                 955                 960 


Glu Glu Lys Ala Ile Leu Ile Met Glu Asp Leu Asn Ile Gly Phe Lys 
                965                 970                 975     


Arg Gly Arg Phe Lys Val Glu Lys Gln Val Tyr Gln Lys Phe Glu Lys 
            980                 985                 990         


Met Met Ile Asp Lys Leu Asn Tyr  Leu Val Phe Lys Asn  Lys Glu Pro 
        995                 1000                 1005             


Leu Glu  Pro Gly Gly Ser Leu  Asn Ala Tyr Gln Leu  Thr Ser Lys 
    1010                 1015                 1020             


Phe Asp  Ser Phe Lys Lys Leu  Gly Lys Gln Ser Gly  Phe Ile Phe 
    1025                 1030                 1035             


Tyr Val  Pro Ser Ala Tyr Thr  Ser Lys Ile Asp Pro  Thr Thr Gly 
    1040                 1045                 1050             


Phe Tyr  Asn Phe Ile Arg Val  Asp Val Pro Asn Leu  Glu Lys Gly 
    1055                 1060                 1065             


Lys Glu  Phe Phe Ser Lys Phe  Glu Lys Ile Ile Tyr  Asn Thr Lys 
    1070                 1075                 1080             


Glu Asp  Tyr Phe Glu Phe His  Cys Lys Tyr Gly Lys  Phe Val Pro 
    1085                 1090                 1095             


Glu Pro  Lys Asn Lys Asp Asn  Asp Arg Lys Thr Lys  Glu Ser Leu 
    1100                 1105                 1110             


Thr Tyr  Tyr Asn Ala Ile Lys  Asp Thr Val Trp Val  Val Cys Ser 
    1115                 1120                 1125             


Thr His  His Glu Arg Tyr Lys  Ile Val Arg Asn Lys  Ala Gly Tyr 
    1130                 1135                 1140             


Tyr Glu  Ser Gln Pro Val Asp  Val Thr Lys Asn Leu  Arg Asp Ile 
    1145                 1150                 1155             


Phe Ser  Glu Ala Asn Ile Asn  Tyr Ser Asp Gly Lys  Asp Ile Lys 
    1160                 1165                 1170             


Pro Ile  Ile Ile Glu Ser Asn  Asn Ala Lys Leu Leu  Lys Ser Ile 
    1175                 1180                 1185             


Ala Glu  Gln Leu Lys Leu Ile  Leu Ala Met Arg Tyr  Asn Asn Gly 
    1190                 1195                 1200             


Lys His  Asp Asp Asp Glu Lys  Asp Tyr Ile Leu Ser  Pro Val Lys 
    1205                 1210                 1215             


Asn Lys  Gln Gly Lys Phe Phe  Cys Ser Leu Asp Gly  Asp Gln Ser 
    1220                 1225                 1230             


Leu Pro  Ile Asn Ala Asp Ala  Asn Gly Ala Tyr Asn  Ile Ala Leu 
    1235                 1240                 1245             


Lys Gly  Leu Leu Leu Ile Glu  Lys Ile Lys Lys Gln  Gln Gly Lys 
    1250                 1255                 1260             


Ala Lys  Asp Leu Tyr Ile Ser  Asn Leu Glu Trp Phe  Met Phe Met 
    1265                 1270                 1275             


Met Ser  Arg 
    1280     


<210>  66
<211>  1332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  66

Met Lys Ser Ile Phe Asp Asn Phe Thr Gly Leu Tyr Ser Leu Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Glu Leu Arg Pro Val Gly Gln Thr Leu Glu Asn Ile 
            20                  25                  30          


Lys Asn Gly His Phe Leu Glu Ser Asp Lys Lys Met Ala Asp Asp Tyr 
        35                  40                  45              


Gln Asp Val Lys Lys Ile Ile Asp Asn Tyr His Lys Phe Phe Ile Asp 
    50                  55                  60                  


Asp Val Leu Lys Gly Ala Ser Phe Asp Trp Ala Leu Leu Glu Lys Glu 
65                  70                  75                  80  


Leu Thr Asp Phe Asn Lys Asn Lys Thr Asp Asp Ser Lys Val Glu Ala 
                85                  90                  95      


Glu Gln Lys Lys Leu Arg Glu Gln Ile Ala Lys Thr Leu Ala Gly Asp 
            100                 105                 110         


Lys Arg Phe Lys Ser Leu Thr Ala Ser Thr Pro Asn Asp Leu Phe Asn 
        115                 120                 125             


Lys Asp Lys Asp Phe Ile Gly Trp Leu Glu Gln Ser Ser Val Lys Glu 
    130                 135                 140                 


Ile Arg Lys Asp Ala Leu Asp Thr Phe Lys Lys Phe Ser Ser Tyr Phe 
145                 150                 155                 160 


Lys Gly Phe Gln Glu Asn Arg Lys Asn Val Tyr Ser Ala Asp Asp Ile 
                165                 170                 175     


Pro Thr Ala Val Pro Tyr Arg Ile Val Asn Asp Asn Phe Pro Lys Phe 
            180                 185                 190         


Leu Gln Asn Ile Ser Ile Phe Lys Thr Ile Gln Glu Lys Cys Pro Gln 
        195                 200                 205             


Val Ile Ala Asp Val Glu Asn Glu Leu Ala Ser Tyr Leu Gly Lys Glu 
    210                 215                 220                 


Lys Leu Ala Asp Ile Phe Thr Val Gln Ala Phe Asn Lys Tyr Leu Cys 
225                 230                 235                 240 


Gln Gly Gly Lys Glu Asn Gln Arg Gly Ile Asp Phe Tyr Asn Gln Val 
                245                 250                 255     


Ile Gly Gly Ile Ala Glu Lys Glu Gly Gly Val Asn Leu Arg Gly Ile 
            260                 265                 270         


Asn Gln Phe Leu Asn Leu Tyr Trp Gln Gln His Pro Asp Phe Ala Lys 
        275                 280                 285             


Glu Asn Arg Arg Ile Lys Met Val Pro Leu Tyr Lys Gln Ile Leu Ser 
    290                 295                 300                 


Asp Arg Ser Ser Leu Ser Phe Lys Ile Glu Thr Ile Asp Thr Asp Glu 
305                 310                 315                 320 


Glu Leu Lys Thr Ala Ile Ser Glu Tyr Ala Asp Lys Leu Glu Ser Lys 
                325                 330                 335     


Ser Asn Asp Glu Lys Lys Ser Val Leu Asp Val Cys Val Glu Leu Phe 
            340                 345                 350         


Asp Ser Ile Lys Glu Gln Asn Leu Gln Glu Ile Tyr Val Asn Arg Lys 
        355                 360                 365             


Asp Ile Asn Asn Ile Ser Arg Ile Leu Thr Gly Asp Trp Ser Trp Leu 
    370                 375                 380                 


Gln Ser Arg Met Asn Leu Tyr Ala Asp Glu Val Phe Thr Thr Lys Ala 
385                 390                 395                 400 


Glu Lys Thr Arg Trp Gln Lys Ser Val Asp Gly Asp Glu Gly Glu Asn 
                405                 410                 415     


Lys Ser Lys Gly Ala Tyr Ser Leu Ala Glu Leu Asn Arg Val Leu Glu 
            420                 425                 430         


Tyr Ala Ser Glu Asn Val Ala Glu Thr Asp Ile Arg Ile Thr Asp Tyr 
        435                 440                 445             


Phe Cys His Arg Asn Arg Phe Tyr Tyr Glu Lys Glu Ser Gly Leu Phe 
    450                 455                 460                 


Lys Gln Gly Glu Glu Leu Val Ala Leu Ser Ile Lys Glu Ser Cys Glu 
465                 470                 475                 480 


Asp Ile Leu Ser Lys Arg Lys Ala Met Asn Glu Ala Phe Ala Asn Ile 
                485                 490                 495     


Ser Glu Ser Asn Ser Leu Arg Asp Asn Ser Glu Asp Ile Ala Lys Thr 
            500                 505                 510         


Lys Thr Tyr Leu Asp Ser Val Gln Asp Leu Leu His Arg Ile Lys Pro 
        515                 520                 525             


Leu Lys Val Asn Gly Leu Gly Asp Pro Ser Phe Tyr Ala Val Phe Asp 
    530                 535                 540                 


Ser Ile Tyr Ser Ala Leu Ser Glu Val Ile Ser Ile Tyr Asn Lys Thr 
545                 550                 555                 560 


Arg Asn Tyr Ile Thr Arg Lys Ala Glu Ser Pro Glu Lys Tyr Lys Leu 
                565                 570                 575     


Asn Phe Asp Asn Pro Thr Leu Ala Asn Gly Trp Asp Leu Asn Lys Glu 
            580                 585                 590         


Lys Asp Asn Thr Cys Val Leu Leu Arg Lys Asn Gly Met Tyr Tyr Leu 
        595                 600                 605             


Gly Ile Met Asn Pro Lys Asp Lys Pro Lys Phe Ala Glu Lys Tyr Asp 
    610                 615                 620                 


Cys Gly Thr Glu Ser Cys Tyr Glu Lys Met Ile Tyr Lys Leu Leu Pro 
625                 630                 635                 640 


Gly Pro Asn Lys Met Leu Pro Lys Val Phe Phe Ser Thr Lys Gly Lys 
                645                 650                 655     


Lys Gln Tyr Asn Pro Pro Glu Asn Ile Leu His Gly Tyr Glu Gln Gly 
            660                 665                 670         


Lys His Lys Lys Gly Val Ala Phe Asp Ile Asn Phe Cys His Glu Leu 
        675                 680                 685             


Ile Asp Trp Phe Lys Ser Ala Ile Asn Gln His Glu Asp Trp Lys Lys 
    690                 695                 700                 


Phe Gly Phe Lys Phe Ser Asp Thr Lys Ser Tyr Lys Asp Ile Ser Asp 
705                 710                 715                 720 


Phe Tyr Arg Glu Val Thr Glu Gln Gly Tyr Lys Leu Thr Phe Ile Asn 
                725                 730                 735     


Ile Pro Glu Ser Glu Ile Ser Lys Met Val Ser Glu Gly Lys Leu Tyr 
            740                 745                 750         


Leu Phe Gln Ile Tyr Asn Met Asp Phe Ala Pro Gly Ala Asn Gly Met 
        755                 760                 765             


Pro Asn Met His Thr Leu Tyr Trp Lys Asn Leu Phe Ser Glu Glu Asn 
    770                 775                 780                 


Leu Lys Asp Val Val Leu Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
785                 790                 795                 800 


Arg Pro Ala Gly Ile Lys Glu Pro Val Val His Ala Lys Gly Ser Tyr 
                805                 810                 815     


Leu Val Asn Arg Ile Thr Lys Asp Gly Glu Pro Ile Pro Glu Lys Ile 
            820                 825                 830         


His Asp Glu Ile Tyr Arg Asn Ala Asn Gly Asn Leu Asn Asn Leu Ser 
        835                 840                 845             


Lys Glu Ala Ser Glu Tyr Lys Glu Ser His Lys Val Val Ile Lys Gln 
    850                 855                 860                 


Ala Ser His Glu Ile Ile Lys Asp Arg His Tyr Thr Glu Pro Lys Phe 
865                 870                 875                 880 


Leu Phe His Ile Pro Leu Thr Ile Asn Phe Lys Ala Pro Ser Met Lys 
                885                 890                 895     


Pro Thr Val Cys Thr Ala Ile Gln Asn Glu Asn Val Arg Arg Phe Leu 
            900                 905                 910         


Lys Asn Asn Pro Asp Val Asn Ile Ile Gly Leu Asp Arg Gly Glu Arg 
        915                 920                 925             


Asn Leu Ile Tyr Leu Ser Leu Ile Asn Gln Lys Gly Glu Ile Ile Lys 
    930                 935                 940                 


Gln Phe Ser Phe Asn Asp Val Glu Arg Glu Gln Asn Gly Gln Thr Val 
945                 950                 955                 960 


Lys Val Asn Tyr His Glu Lys Leu Asp Gln Arg Glu Lys Glu Arg Asp 
                965                 970                 975     


Ala Ala Arg Lys Ser Trp Gln Ala Ile Gly Lys Ile Ala Glu Leu Lys 
            980                 985                 990         


Glu Gly Tyr Leu Ser Ala Val Ile  His Gln Leu Thr Lys  Leu Met Val 
        995                 1000                 1005             


Glu Tyr  Asn Ala Ile Val Val  Met Glu Asp Leu Asn  Phe Gly Phe 
    1010                 1015                 1020             


Lys Arg  Gly Arg Phe His Val  Glu Lys Gln Val Tyr  Gln Lys Phe 
    1025                 1030                 1035             


Glu His  Met Leu Ile Asp Lys  Leu Asn Tyr Leu Val  Phe Lys Asp 
    1040                 1045                 1050             


Arg Gly  Leu Asn Glu Pro Gly  Gly Ala Leu Asn Gly  Tyr Gln Leu 
    1055                 1060                 1065             


Ala Gly  Gln Phe Glu Ser Phe  Gln Lys Leu Gly Lys  Gln Ser Gly 
    1070                 1075                 1080             


Met Leu  Phe Tyr Val Pro Ala  Ala Tyr Thr Ser Lys  Ile Asp Pro 
    1085                 1090                 1095             


Lys Thr  Gly Phe Val Ser Met  Met Asn Phe Lys Asp  Leu Thr Asn 
    1100                 1105                 1110             


Val His  Lys Lys Arg Asp Phe  Phe Ser Lys Phe Glu  Asp Ile His 
    1115                 1120                 1125             


Phe Asp  Glu Ala Thr Cys Ser  Phe Val Phe Thr Phe  Asp Tyr Lys 
    1130                 1135                 1140             


Asn Phe  Asn Gly Lys Ala Lys  Glu Glu Met Lys Gln  Thr Lys Trp 
    1145                 1150                 1155             


Ala Val  Tyr Ser Arg Glu Lys  Arg Ile Val Tyr Phe  Ser Lys Thr 
    1160                 1165                 1170             


Lys Ser  Ser Glu Asp Ile Met  Pro Thr Glu Lys Leu  Arg Ala Leu 
    1175                 1180                 1185             


Phe Glu  Ser Asp Gly Ile Glu  Tyr Lys Ser Gly Asn  Asn Ile His 
    1190                 1195                 1200             


Asp Ser  Val Met Ala Val Gly  Ala Asp Leu Lys Glu  Gly Ala Lys 
    1205                 1210                 1215             


Pro Ser  Lys Glu Ile Ala Asp  Phe Trp Asp Gly Leu  Leu Tyr Asn 
    1220                 1225                 1230             


Phe Lys  Leu Ile Leu Gln Met  Arg Asn Ser Asn Ala  Lys Thr Gly 
    1235                 1240                 1245             


Glu Asp  Tyr Ile Ile Ser Pro  Val Met Ala Ser Asp  Gly Thr Phe 
    1250                 1255                 1260             


Phe Asp  Ser Arg Val Glu Ala  Lys Lys Gly Lys Asp  Ala Lys Leu 
    1265                 1270                 1275             


Pro Leu  Asp Ala Asp Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys 
    1280                 1285                 1290             


Gly Leu  Ser Leu Ile Asn Lys  Ile Asn Leu Ala Gly  Glu Asp Glu 
    1295                 1300                 1305             


Leu Lys  Lys Phe Asp Met Lys  Ile Ser Asn Glu Asp  Trp Phe Asn 
    1310                 1315                 1320             


Phe Ala  Gln Glu Lys Lys Tyr  Ala Glu 
    1325                 1330         


<210>  67
<211>  1345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  67

Met Thr Lys Gln Asn Lys Ser Val Thr Gln Asn Thr Lys Arg Lys Asn 
1               5                   10                  15      


Phe Gly Glu Phe Thr Asn Leu Tyr Ser Leu Ser Lys Thr Leu Arg Phe 
            20                  25                  30          


Glu Leu Lys Pro Val Lys Ala Thr Lys Thr Ile Leu Glu Val Glu Arg 
        35                  40                  45              


Lys Asp Arg Glu Asn Phe Lys Lys Asp Arg Lys Ile Ala Lys Asn Tyr 
    50                  55                  60                  


Gln Lys Leu Lys Gly Ile Leu Asn Glu Leu His Gln Glu Phe Ile Gln 
65                  70                  75                  80  


Asp Val Met Arg Glu Phe Ser Phe Gln Glu Lys Glu Ile Lys Glu Phe 
                85                  90                  95      


Glu Glu Arg Tyr Leu Glu Ala Leu Asn Phe Lys Glu Lys Asp Asn Tyr 
            100                 105                 110         


Lys Lys Arg Thr Gln Leu Lys Asn Ala Tyr Glu Lys Val Ala Lys Lys 
        115                 120                 125             


Leu Ala Gly Lys Ile Ala Thr Ala Phe Gly Lys Tyr Asn Gln Glu Lys 
    130                 135                 140                 


Tyr Gly Val Lys Phe Thr Lys Lys Asn Leu Thr Gly Glu Asn Val Phe 
145                 150                 155                 160 


Asp Ile Leu Glu Gly Lys Tyr Lys Gly Asp Lys Lys Ile Leu Gly Ile 
                165                 170                 175     


Ile His Thr Phe Lys Phe Lys Pro Thr Lys Glu Glu Lys Lys Gln Gly 
            180                 185                 190         


Lys Glu Ala Val Asn Phe Ser Thr Tyr Leu Gly Gly Phe Asn Gln Asn 
        195                 200                 205             


Arg Glu Asn Phe Tyr Lys Gly Glu Met Lys Ala Gly Gln Phe Ala Thr 
    210                 215                 220                 


Arg Thr Ile Glu Asn Leu Ile Gln Phe Leu Lys Asn Lys Lys Leu Phe 
225                 230                 235                 240 


Ile Asp Lys Tyr Lys Asp Asn Tyr Gln Lys Ile Gly Phe Ser Gln Glu 
                245                 250                 255     


Gln Val Glu Ile Phe Asn Leu Asn Tyr Phe Asn Asn Leu Phe Leu Gln 
            260                 265                 270         


Glu Gly Leu Asp Val Tyr Asn Gly Ile Leu Gly Ala Lys Lys Gly Glu 
        275                 280                 285             


Lys Asn Thr Glu Asn Asp Gly Leu Asn Gln Lys Ile Asn Leu Phe Lys 
    290                 295                 300                 


Gln Lys Glu Lys Thr Arg Cys Lys Ala Asn Gly Glu Lys Phe Asn Lys 
305                 310                 315                 320 


Ser Asp Tyr Pro Ile Phe Lys Glu Leu Tyr Lys Gln Ile Gly Ser Ile 
                325                 330                 335     


Lys Lys Asp Asn Asp Val Tyr Val Glu Ile Lys Ser Asp Glu Glu Leu 
            340                 345                 350         


Val Asn Val Leu Gln Ser Leu Pro Glu Lys Thr Ala Asn Thr Leu Arg 
        355                 360                 365             


Glu Val Gln Lys Phe Tyr Glu Asn Phe Phe Asp Lys Ile Phe Asn Asp 
    370                 375                 380                 


Glu Phe Asp Leu Asp Lys Ile Tyr Leu Pro Lys Ser Val Gly Thr His 
385                 390                 395                 400 


Phe Ser His Leu Ala Phe Ser Asp Trp Ser Lys Leu Ala Phe Val Phe 
                405                 410                 415     


Asn Lys Arg Trp Arg Asn Glu Lys Val Lys Ile Lys Glu Gly Glu Asp 
            420                 425                 430         


Val Asn Val Gln Ser Arg Ser Leu Ala Asp Ile Lys Lys Arg Met Glu 
        435                 440                 445             


Glu Ile Leu Glu Met Asp Gly Gly Val Ser Phe Gly Lys Thr Tyr Cys 
    450                 455                 460                 


Gln Lys Val Gly Leu Glu Lys Glu Ala Arg Thr Ile Glu Asp Val Trp 
465                 470                 475                 480 


Ser Gly Phe Trp Lys Ile Ile Gln Tyr His Ile Asn Ser Gln Phe Ile 
                485                 490                 495     


Gly Gly Glu Lys Glu Val Phe Asp Lys Glu Lys Lys Asp Asp Lys Thr 
            500                 505                 510         


Glu Lys Ile Gln Thr Ile Asp Asp Leu Gln Glu Glu Tyr Leu Gln Ala 
        515                 520                 525             


Thr Glu Met Tyr Arg Glu Arg Met Val Glu Ser Glu Glu Gly Leu Asn 
    530                 535                 540                 


Asp Gly Glu Glu Lys Glu Ile Lys Thr Lys Leu Lys Asn Tyr Leu Asp 
545                 550                 555                 560 


Arg Ile Lys Asp Ile Glu Arg Ile Ala Arg Tyr Phe Asp Leu Arg Lys 
                565                 570                 575     


His Phe Asp Asp Ile Asp Glu Ala Ser Lys Asp Gly Asp Phe Tyr Phe 
            580                 585                 590         


Ile Tyr Gln Glu Leu Leu Gln Asp Ile Ser Glu Ala Lys Ile Asn Asp 
        595                 600                 605             


His Tyr Asn Glu Ile Arg Asn Tyr Leu Thr Lys Ala Asn Val Val Asp 
    610                 615                 620                 


Asp Lys Phe Lys Leu Asn Phe Asn Asp Gly Gln Thr Leu Ser Gly Trp 
625                 630                 635                 640 


Asp Leu Asn Lys Glu Thr Glu Lys Phe Ser Leu Ile Phe Lys Arg Lys 
                645                 650                 655     


Val Asp Gly Gly Val Glu Tyr Tyr Leu Gly Ile Ile Asn Lys Glu Lys 
            660                 665                 670         


Asn Lys Thr Ile Phe Asp Lys Lys Lys His Pro Glu Ile Phe Thr Glu 
        675                 680                 685             


Asn Ser Glu Phe Glu Lys Met Glu Tyr Lys Leu Phe Pro Ser Pro Ser 
    690                 695                 700                 


Lys Met Leu Pro Lys Ile Ala Phe Thr Lys Asn Lys Glu Gly Glu Arg 
705                 710                 715                 720 


Ile Lys Pro Val Phe Leu Asp Glu Asn Ala Gly Lys Glu Ile Ala Gln 
                725                 730                 735     


Ile Lys Lys Glu Phe Ala Leu Phe Gln Asp Ala Lys Lys Glu Asp Lys 
            740                 745                 750         


Asn Lys Trp Ser Asp Glu Phe Asp Arg Lys Lys Leu Asn Lys Leu Ile 
        755                 760                 765             


Asp Tyr Tyr Lys Leu Val Leu Glu Lys His Pro Glu Lys Tyr Met Gln 
    770                 775                 780                 


Thr Phe Asn Phe Val Phe Lys Ser Ser Ala Lys Tyr Lys Asn Leu Gly 
785                 790                 795                 800 


Glu Phe Asn Asp Asp Val Ala Arg Gln Asn Tyr Val Thr Lys Phe Val 
                805                 810                 815     


Ser Val Asp Lys Asp Tyr Ile Asp Gln Lys Val Glu Ser Gly Glu Leu 
            820                 825                 830         


Tyr Leu Phe Lys Ile His Asn Lys Asp Trp Asn Leu Thr Lys Ala Gly 
        835                 840                 845             


Asp Thr Lys Lys Gln Ser Lys Lys Asn Leu His Thr Ile Tyr Phe Glu 
    850                 855                 860                 


Glu Leu Phe Ser Glu Lys Asn Ile Ala Glu Pro Val Phe Lys Leu Ser 
865                 870                 875                 880 


Gly Gly Ala Glu Val Phe Phe Arg Asp Ala Ile Glu Lys Lys Lys Gln 
                885                 890                 895     


Lys Lys Lys Lys Asp Lys Lys Gly Lys Glu Ile Leu Glu Lys Phe Arg 
            900                 905                 910         


Phe Thr Lys Asn Lys Ile Leu Phe His Val Pro Ile Thr Ile Asn Tyr 
        915                 920                 925             


Gly Lys Pro Ser Ile Asn Gln Gly Gln Phe Asn Gln Lys Ile Asn Glu 
    930                 935                 940                 


Phe Ile Ala Asp Asn Ser Arg Ser Val Asn Ile Leu Gly Ile Asp Arg 
945                 950                 955                 960 


Gly Glu Lys His Leu Leu Tyr Tyr Ser Leu Val Asp Asn Asn Gly Lys 
                965                 970                 975     


Ile Ile Lys Ser Gly Ser Leu Asn Glu Ile Asn Gly Val Asp Tyr His 
            980                 985                 990         


Glu Lys Leu Asp Lys Ala Glu Lys  Glu Arg Gln Glu Ala  Arg Lys Ser 
        995                 1000                 1005             


Trp Gln  Lys Ile Asn Gln Ile  Lys Asn Leu Lys Ala  Gly Tyr Ile 
    1010                 1015                 1020             


Ser Gln  Val Ile Lys Lys Ile  Val Asp Leu Ala Ile  Glu Asn Asn 
    1025                 1030                 1035             


Ala Ile  Ile Val Leu Glu Asp  Leu Asn Phe Gly Phe  Lys Ser Phe 
    1040                 1045                 1050             


Arg Gln  Lys Ile Glu Lys Asn  Val Tyr Gln Gln Phe  Glu Lys Ala 
    1055                 1060                 1065             


Leu Ile  Asp Lys Leu Gly Phe  Val Thr Asp Lys Glu  Lys Leu Asn 
    1070                 1075                 1080             


His Arg  Gln Ala Pro Gln Leu  Ser Ala Pro Phe Glu  Ser Phe Glu 
    1085                 1090                 1095             


Lys Met  Gly Lys Gln Thr Gly  Ile Val Phe Tyr Val  Leu Ala Thr 
    1100                 1105                 1110             


Asn Thr  Ser Lys Val Cys Pro  Gln Cys Gln Trp Lys  Lys Asn Ile 
    1115                 1120                 1125             


Phe Pro  His Tyr Ser Thr Lys  Lys Ser Ile Ala Glu  Asn Leu Gln 
    1130                 1135                 1140             


Lys Gln  Tyr Lys Met Lys Met  Tyr Trp Arg Glu Asn  Glu Asn Arg 
    1145                 1150                 1155             


Phe Glu  Phe Glu Tyr Lys Gly  Asp Gly Asp Lys Glu  Phe Ser Ser 
    1160                 1165                 1170             


Ile Phe  Ser Asn Val Asp Arg  Val Arg Tyr Asp Lys  Arg Ala Asn 
    1175                 1180                 1185             


Asn Asn  Gln Gly Gly Tyr Val  Ile Tyr Gln Ile Asp  Ser Thr Thr 
    1190                 1195                 1200             


Lys Glu  Lys Asp Gly Arg Asn  Ile Lys Glu Lys Ser  Ile Thr Asn 
    1205                 1210                 1215             


Leu Leu  Lys Glu Leu Leu Leu  Glu Lys Phe Glu Ile  Asp Asn Leu 
    1220                 1225                 1230             


Glu Gly  Glu Leu Leu Val Lys  Leu Ser Glu Lys Ser  Pro Asp Val 
    1235                 1240                 1245             


Ser Lys  Glu Thr Ile Lys Asp  Phe Phe Gly Leu Leu  Asn Ser Ile 
    1250                 1255                 1260             


Leu Asn  Ile Arg Asn Ser Met  Thr Asp Thr Glu Glu  Asp Tyr Ile 
    1265                 1270                 1275             


Gln Cys  Pro Ala Cys Gly Phe  Asp Thr Arg Lys Glu  Asn Lys Ile 
    1280                 1285                 1290             


Gly Ile  Lys Asn Gly Asp Asp  Asn Gly Ala Tyr Asn  Ile Ala Leu 
    1295                 1300                 1305             


Arg Gly  Arg Phe Leu Ile Glu  Arg Ile Lys Lys Ala  Lys Lys Glu 
    1310                 1315                 1320             


Asp Lys  Lys Pro Asn Leu Thr  Phe Ser Asn Asn Asp  Tyr Phe Gln 
    1325                 1330                 1335             


Trp Val  Arg Glu Phe Val Lys  
    1340                 1345 


<210>  68
<211>  1265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  68

Met Arg Thr Thr Thr Ser Leu Asp Ala Phe Thr Asn Arg Tyr Ala Leu 
1               5                   10                  15      


Ser Lys Thr Leu Arg Phe Glu Leu Lys Pro Ile Gly Asn Thr Gln Met 
            20                  25                  30          


Met Leu Glu Gln Asn Asn Val Phe Ala Lys Asp Arg Ala Ile Arg Glu 
        35                  40                  45              


Lys Tyr Glu Lys Thr Lys Pro Trp Ile Asp Leu Leu His Arg Glu Phe 
    50                  55                  60                  


Val Ala Glu Ser Leu Gln Asn Ala Gln Leu Gly Asn Leu Asp Asp Tyr 
65                  70                  75                  80  


Tyr Ala Ala Leu Gln Asn Val Gln Lys Ile Thr Lys Asp Thr Asn Ala 
                85                  90                  95      


Glu Asp Lys Lys Arg Trp Lys Lys Gly Phe Glu Lys Gln Glu Lys Arg 
            100                 105                 110         


Leu Arg Lys Glu Val Val Ala Leu Phe Asp Lys Ala Ala His Ile Trp 
        115                 120                 125             


Ala Thr Gln Arg Tyr Pro Gln Leu Lys Lys Lys Thr Lys Asp Phe Leu 
    130                 135                 140                 


Phe Glu Glu Gly Val Phe Glu His Val Leu Phe Ala Arg Tyr Gly Ser 
145                 150                 155                 160 


Ala Pro Asp Thr Thr Val Lys Ile Val Thr Ser Asn Pro Glu Thr Gly 
                165                 170                 175     


Glu Val Ile Asp Glu Arg Glu Glu Ser Ile Phe Lys Gly Trp Lys Gly 
            180                 185                 190         


Phe Thr Gly Tyr Phe Asp Lys Phe Phe Glu Thr Arg Lys Asn Phe Tyr 
        195                 200                 205             


Lys Asp Asn Gly Thr Ala Thr Ala Ile Ala Thr Arg Ala Ile Asn Gln 
    210                 215                 220                 


Asn Leu Arg Arg Phe Ala Glu Asn Met Gln Lys Leu Thr Asp Ile Lys 
225                 230                 235                 240 


Asn Asn Tyr Pro Glu Leu Leu Ala His Thr Asp Phe Gly Asp Phe Asp 
                245                 250                 255     


Ile Ala His Ala Gln Ser Leu Asp Phe Tyr Ala Arg Thr Cys Leu Leu 
            260                 265                 270         


Gln Glu Gly Ile Asp Ala Tyr Asn Lys Lys Phe Val Gly Val Leu Lys 
        275                 280                 285             


Ser Ala Ile Asn Glu Tyr Gln Gln Lys Asn Lys Gly Val Arg Ile Ser 
    290                 295                 300                 


Tyr Pro Lys Thr Leu Asp Asn Gln Ile Leu Gly Glu Arg Glu Arg Arg 
305                 310                 315                 320 


Leu Phe Asp Val Ile Glu Asp Asp Arg Glu Leu His Asp Val Phe Arg 
                325                 330                 335     


Ala Phe Val Asp Asp Gly Thr Val Phe Ala Ala Glu Met Arg Gln Leu 
            340                 345                 350         


Ala Gln Ala Phe Ser Ala Gln Asn Gly Thr Tyr Asp Tyr Thr Gln Ile 
        355                 360                 365             


Tyr Ile Ser Lys Lys Gly Phe Glu Thr Ile Ser Arg Lys Tyr Thr His 
    370                 375                 380                 


Asp Thr Arg Ala Trp His Asp Ala Leu Ala Asp Val Phe Lys Ala Lys 
385                 390                 395                 400 


Ala Lys Lys Arg Ile Ala Thr Thr Ala Ser Gly Glu Lys Lys Phe Pro 
                405                 410                 415     


Ala Tyr Ile Pro Val Ala Tyr Ile Thr Gln Ala Leu Thr Leu Val Gln 
            420                 425                 430         


Glu Ser Glu Asp Thr Glu Cys Thr Trp Lys Glu Arg Tyr Ala Ser Ile 
        435                 440                 445             


Thr Glu Asn Lys Thr Leu Glu Glu Gly Phe Phe Ala Ile Phe Ala Asp 
    450                 455                 460                 


Glu Phe Glu Arg Leu Phe Val His Met Glu Ala Thr Val Gln Asp Thr 
465                 470                 475                 480 


Asp Tyr Val Val Ala Glu Asp Lys Ala Lys Lys Leu Leu Ser Asp Gly 
                485                 490                 495     


Gln Ile Thr Lys Asn Glu Gln Thr Thr Gln Ile Ile Lys Glu Tyr Ala 
            500                 505                 510         


Asp Ala Leu Leu Arg Ile Tyr Gln Met Ala Lys Tyr Phe Ala Val Glu 
        515                 520                 525             


Lys Lys Ser Met Trp Asp Asp Ala Val Ala Ile Asp Asp Thr Phe Tyr 
    530                 535                 540                 


Glu Thr Phe Lys Glu Ile Tyr Gly Asn Thr His Ser Thr Ile Val Ala 
545                 550                 555                 560 


Ser Tyr Asn Leu Leu Arg Asn Tyr Leu Thr Lys Lys Pro Trp Glu Asp 
                565                 570                 575     


Val Gln Lys Trp Lys Leu Asn Phe Glu Asn Pro Thr Leu Leu Asp Gly 
            580                 585                 590         


Trp Asp Lys Asn Lys Glu Ala Ala Asn Phe Gly Val Ile Leu Arg Asp 
        595                 600                 605             


Gly Asp Lys Phe Tyr Leu Gly Ile Met Arg Lys Gly His Asn Asn Ile 
    610                 615                 620                 


Phe Ala Asn Gln His His Ser Asn Phe Glu Gly Gln Gly Leu Gln Lys 
625                 630                 635                 640 


Met Val Tyr Lys Phe Phe Pro Asp Pro Lys Lys Met Phe Pro Lys Val 
                645                 650                 655     


Cys Phe Ser Ala Lys Gly Met Glu Phe Phe Ala Pro Ser Glu Glu Ile 
            660                 665                 670         


Val Arg Ile Tyr Lys Asn Ala Glu Phe Lys Ser Gly Asp Thr Phe Asn 
        675                 680                 685             


Val Glu Ser Met Gln Lys Leu Ile Asp Phe Tyr Lys Asn Ala Leu Gln 
    690                 695                 700                 


Lys Tyr Asp Gly Trp Lys Ile Tyr Asp Phe Lys His Leu Lys Asp Thr 
705                 710                 715                 720 


Ala Gln Tyr Thr Ser Asn Ile Gly Glu Phe Tyr Asp Asp Val Ala Lys 
                725                 730                 735     


Gly Gly Tyr Gln Leu Gly Trp Gln Asn Ile Ser Lys Glu Tyr Val Glu 
            740                 745                 750         


Glu Lys Asn Ala Asn Gly Glu Leu Tyr Leu Phe Gln Ile Lys Asn Lys 
        755                 760                 765             


Asp Trp Asn Asp Gly Ala Thr Gly Arg Lys Asn Leu His Thr Leu Tyr 
    770                 775                 780                 


Phe Glu Tyr Leu Phe Ser Glu Lys Asn Ala Ala Ala Asp Phe Val Phe 
785                 790                 795                 800 


Arg Leu Asn Gly Gly Ala Glu Val Phe Tyr Arg Pro Ala Ala Ile Glu 
                805                 810                 815     


Ser Lys Thr Glu Arg Arg Gly Asn Arg Glu Val Ala Ala Lys Lys Arg 
            820                 825                 830         


Tyr Thr Gln Asp Lys Val Phe Leu His Val Pro Ile Thr Leu Asn Arg 
        835                 840                 845             


Thr Ala Gly Asp Val Lys Thr Ser Ala Phe Asn Asp Ala Val Asn Arg 
    850                 855                 860                 


Phe Leu Ala Gly Asn Pro Asp Ile Asn Ile Met Gly Ile Asp Arg Gly 
865                 870                 875                 880 


Glu Lys His Leu Ala Tyr Tyr Ser Ile Ile Asp Gln Asn Gly Asn Arg 
                885                 890                 895     


Ile Val Ser Gly Ser Phe Asn Thr Ile Gly Ser Lys Asp Tyr His Ala 
            900                 905                 910         


Leu Leu Thr Glu Arg Gln Gly Ala Arg Glu Glu Ala Arg Lys Asn Trp 
        915                 920                 925             


Gln Arg Val Glu Gln Ile Lys Asp Leu Lys Lys Gly Tyr Ile Ser Leu 
    930                 935                 940                 


Val Val Arg Glu Ile Ala Asp Leu Ala Ile Lys His Asn Ala Ile Ile 
945                 950                 955                 960 


Val Leu Glu Asn Leu Asn Met Arg Phe Lys Gln Ile Arg Gly Gly Ile 
                965                 970                 975     


Glu Lys Ser Val Tyr Gln Gln Leu Glu Lys Ala Leu Ile Glu Lys Leu 
            980                 985                 990         


Asn Phe Leu Val Asn Lys Gly Glu  Val Asp Ala Thr Lys  Ala Gly His 
        995                 1000                 1005             


Leu Leu  Arg Ala Tyr Gln Leu  Ala Ala Pro Phe Glu  Thr Phe Glu 
    1010                 1015                 1020             


Lys Met  Gly Asn Gln Thr Gly  Ile Ile Phe Tyr Thr  Thr Ala Ser 
    1025                 1030                 1035             


Tyr Thr  Ser Gln Val Asp Pro  Val Thr Gly Trp Arg  Pro His Val 
    1040                 1045                 1050             


Tyr Leu  Lys Tyr Arg Asn Ala  Gln Lys Thr Lys Glu  Asp Ile Leu 
    1055                 1060                 1065             


Arg Ile  Phe Asp Asp Ile Val  Phe Asn Asp Glu Lys  Gln Arg Phe 
    1070                 1075                 1080             


Glu Phe  Ala Tyr Arg His Asn  Gly Val Ser Trp Thr  Val Cys Ser 
    1085                 1090                 1095             


Ser Val  Glu Arg His Arg Trp  Asn Arg Ser Asn Asn  Ala Gly Lys 
    1100                 1105                 1110             


Gly Gly  Tyr Asp Val Phe Pro  Val Glu Gly Glu Gly  Ser Ile Thr 
    1115                 1120                 1125             


Gln Arg  Leu Gln Glu Ala Cys  Ala Gln Arg Gly Ile  Asp Thr Thr 
    1130                 1135                 1140             


Arg Asn  Ile Leu Ala Gln Ile  Asp Glu Leu Asp Glu  Ser Ala Ser 
    1145                 1150                 1155             


Ala Thr  Val Ser Phe Leu Arg  Asp Leu Cys Phe Tyr  Phe Arg Leu 
    1160                 1165                 1170             


Ile Cys  Gln Ile Arg Asn Thr  Asp Asp Gly Ala Asp  Asp Ile Asn 
    1175                 1180                 1185             


Ala Gln  Asp Phe Leu Met Ser  Pro Val Glu Pro Phe  Phe Asp Thr 
    1190                 1195                 1200             


Arg Asn  Ala Gln Glu Gln Tyr  Pro Gln Asn Gly Asp  Glu Asn Gly 
    1205                 1210                 1215             


Ala Tyr  Asn Ile Ala Arg Lys  Gly Ile Ile Ile Leu  Gln Lys Ile 
    1220                 1225                 1230             


Thr Ala  Trp Gly Arg Ser Gln  Asp Thr Gln Arg Arg  Tyr Pro Asp 
    1235                 1240                 1245             


Thr Phe  Val Ser Gln Asp Glu  Trp Asp Thr Phe Leu  Thr Gln His 
    1250                 1255                 1260             


Thr Thr  
    1265 


<210>  69
<211>  1259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  69

Met Leu Lys Glu Lys Gln Phe Lys Thr Phe Gly Asp Phe Thr Asn Leu 
1               5                   10                  15      


Tyr Glu Leu Ser Lys Thr Leu Arg Phe Glu Leu Arg Pro Thr Pro Glu 
            20                  25                  30          


Thr Lys Asp Leu Leu Asp Lys Asn Lys Ile Ile Gln Thr Asp Lys Lys 
        35                  40                  45              


Ile Ala Glu Asn Tyr Gln Glu Ile Lys Lys Tyr Phe Asp Lys Leu His 
    50                  55                  60                  


Lys Lys Phe Ile Lys Glu Ala Leu Ser Asn Thr Gln Ile Asp Phe Ser 
65                  70                  75                  80  


Asp Phe Cys Lys Leu Trp Glu Gln Asn Ser Lys Asp Ser Gly Lys Ile 
                85                  90                  95      


Lys Asp Leu Ser Arg Lys Leu Arg Lys Ser Ile Lys Gln Ala Phe Asp 
            100                 105                 110         


Lys Lys Gly Ala Asp Trp His Lys Arg Tyr Leu Glu Lys Gly Ile Lys 
        115                 120                 125             


Leu Lys Lys Lys Asn Leu Asp Ile Leu Phe Glu Glu Arg Val Leu Asp 
    130                 135                 140                 


Ile Leu Lys Glu Glu Phe Lys Asp Asp Val Asp Val Lys Leu Phe Glu 
145                 150                 155                 160 


Ser Phe Lys Gly Phe Ser Thr Tyr Phe Thr Asn Phe His Glu Ser Arg 
                165                 170                 175     


Lys Asn Phe Tyr Lys Asp Asp Gly Thr Ala Ser Ala Ile Ala Thr Arg 
            180                 185                 190         


Ile Ile Asp Glu Asn Leu Lys Arg Phe Cys Asp Asn Ile Lys Val Lys 
        195                 200                 205             


Lys His Ser Lys Lys Leu Ile Ser Glu Leu Asn Glu Arg Glu Ala Lys 
    210                 215                 220                 


Ile Phe Glu Ala Asp Phe Tyr Asn Arg Cys Leu Leu Gln Gln Gly Ile 
225                 230                 235                 240 


Asp Asp Tyr Asn Gln Val Ile Gly Asp Ile Asn Lys Lys Ile Asn Asn 
                245                 250                 255     


Leu Arg Gln Asn Lys Ile Glu Asn Thr Pro Thr Leu Lys Ile Leu Tyr 
            260                 265                 270         


Lys Gln Ile Leu Gly Asp Val Arg Arg Gln Glu Thr Glu Gln Asp Ala 
        275                 280                 285             


Phe Ile Glu Ile Lys Asn Asn Glu Glu Val Phe Asp Phe Leu Gln Asp 
    290                 295                 300                 


Phe Ile Lys His Ser Asp Glu Asn Asn Lys Tyr Phe Lys Asn Leu Phe 
305                 310                 315                 320 


Tyr Lys Phe Ile Glu Gly Lys His Ser Leu Asp Lys Ile Phe Leu Ala 
                325                 330                 335     


Lys Arg Phe Val Asn Thr Ile Ser Gly Lys Trp Phe Ala Ser Trp Glu 
            340                 345                 350         


Val Phe Gly Ala Glu Leu Ile Lys Lys Phe Gly Asn Lys Lys Asp Leu 
        355                 360                 365             


Pro Asp Phe Ile Pro Phe Ala Ala Val Lys Asp Val Leu Gln Asn Cys 
    370                 375                 380                 


Asn Ile Pro Ala Asn Glu Leu Phe Lys Glu Lys Ile Lys Asn Asp Glu 
385                 390                 395                 400 


Asp Lys Asn Ile Tyr Asp Ile Phe Ile Asn Leu Trp Lys Glu Glu Phe 
                405                 410                 415     


Asp Ser Asn Leu Lys Lys Val Glu Glu Ser Lys Lys Glu Val Glu Asn 
            420                 425                 430         


Met Ile Ala Glu Asp Lys Val Tyr Ser Asn Lys Lys Glu Lys Arg Lys 
        435                 440                 445             


Asn Asp Asn Gly Glu Glu Ile Glu Ile Glu Ile Gln Lys Glu Lys Ile 
    450                 455                 460                 


Lys Asn Tyr Ala Asp Ala Ala Met Asn Ile Phe Arg Met Met Lys Tyr 
465                 470                 475                 480 


Phe Leu Leu Glu Lys Asn Gly Lys Thr Val Glu Gly Met Gly Glu Asp 
                485                 490                 495     


Asn Asn Phe Tyr Asn Glu Leu Asn Ile Val Phe Lys Gly Gly Glu Ile 
            500                 505                 510         


Asp Gly Lys Val Tyr Glu Gly Val Lys Thr Tyr Leu Tyr Tyr Asn Glu 
        515                 520                 525             


Phe Arg Asn Tyr Leu Thr Lys Lys Pro Phe Asn Glu Glu Lys Thr Lys 
    530                 535                 540                 


Leu Asn Phe Asp Cys Gly Gln Ile Leu Ser Gly Trp Asp Lys Asn Lys 
545                 550                 555                 560 


Glu Ser Glu Lys Leu Gly Val Ile Leu Arg Lys Asp Asn Lys Tyr Tyr 
                565                 570                 575     


Leu Ala Ile Ile Asn Lys Lys His Asn Lys Ile Phe Asp Val Lys Lys 
            580                 585                 590         


Asn Ser Tyr Ala Tyr Ile Val Gly Asp Asn Phe Tyr Glu Lys Met Glu 
        595                 600                 605             


Tyr Lys Leu Phe Pro Asp Ala Lys Arg Met Ile Pro Lys Ile Ala Phe 
    610                 615                 620                 


Ala Lys Asn Asn Lys Glu Lys Phe Gly Trp Thr Asp Glu Ile Gln Lys 
625                 630                 635                 640 


Ile Lys Asn Glu Tyr Ala Glu Phe Gln Glu Gly Lys Lys Asn Asp Lys 
                645                 650                 655     


Asn Leu Trp Lys Asp Lys Phe Asn Lys Asn Lys Met Glu Lys Leu Ile 
            660                 665                 670         


Thr Tyr Tyr Gln Asn Cys Leu Glu Lys Gly Gly Tyr Lys Asp Ile Tyr 
        675                 680                 685             


Asn Phe Arg Trp Lys Ser Pro Asp Lys Tyr Ser Gly Ile Gly Glu Phe 
    690                 695                 700                 


Asn Asp Glu Ile Asp Arg Gln Ser Tyr Cys Leu Lys Phe Val Lys Val 
705                 710                 715                 720 


Asp Phe Asn Tyr Val Phe Glu Lys Val Lys Ser Gly Glu Leu Tyr Leu 
                725                 730                 735     


Phe Gln Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ala Asp Arg Ala Gln 
            740                 745                 750         


Lys Glu Asn Ile His Thr Glu Tyr Phe Lys Leu Leu Phe Asp Gln Arg 
        755                 760                 765             


Asn Leu Asp Asn Val Val Leu Lys Leu Ser Gly Gly Ala Glu Ile Phe 
    770                 775                 780                 


Tyr Arg Pro Lys Thr Glu Gly Leu Pro Lys Lys Lys Asp Asn Lys Gly 
785                 790                 795                 800 


Asn Glu Val Val Arg His Arg Arg Tyr Ala Asp Asp Lys Tyr Phe Leu 
                805                 810                 815     


His Leu Pro Ile Gln Leu Asn Phe Gly Arg Gly Asn Leu Ser Gly Gly 
            820                 825                 830         


Glu Phe Asn Ser Lys Ile Asn Gln Tyr Leu Ser Glu Gln Arg Glu Ile 
        835                 840                 845             


Lys Ile Ile Gly Ile Asp Arg Gly Glu Lys His Leu Ala Tyr Tyr Ser 
    850                 855                 860                 


Val Ile Asn Gln Asp Gly Lys Ile Glu Glu Ile Glu Ser Leu Asn Thr 
865                 870                 875                 880 


Val Asn Gly Ile Asp Tyr Arg Lys Lys Leu Asp Glu Leu Glu Lys Lys 
                885                 890                 895     


Arg Glu Gln Glu Arg Lys Ser Trp Gln Ser Ile Ser Lys Ile Lys Asp 
            900                 905                 910         


Leu Lys Lys Gly Tyr Ile Ser His Val Ile Lys Lys Ile Cys Asp Leu 
        915                 920                 925             


Ala Ile Glu His Asn Ala Ile Ile Val Phe Glu Asp Leu Ser Gly Gly 
    930                 935                 940                 


Phe Lys Asn Ser Arg Lys Lys Ile Glu Lys Gln Ile Tyr Gln Asn Leu 
945                 950                 955                 960 


Glu Leu Ala Leu Ala Thr Lys Leu Asn Tyr Leu Thr Phe Lys Asp Lys 
                965                 970                 975     


Asn Phe Gly Glu Ser Gly His Tyr Leu Asn Ala Tyr Gln Leu Ala Pro 
            980                 985                 990         


Lys Ile Asp Asn Tyr Gln Asp Ile  Lys Met Gln Thr Gly  Ile Val Phe 
        995                 1000                 1005             


Tyr Thr  Pro Ala Gly Tyr Thr  Ser Ser Thr Cys Pro  Gln Cys Gly 
    1010                 1015                 1020             


Phe Arg  Lys Thr Leu Lys Phe  Asp Tyr Thr Ala Thr  Ile Ser Lys 
    1025                 1030                 1035             


Ala Glu  Asp Leu Ile Arg Gly  Ser Lys Leu Asn Ile  Val Phe Glu 
    1040                 1045                 1050             


Lys Glu  Lys Asn Arg Phe Lys  Ile Asn Tyr Leu Phe  Asn Pro Ile 
    1055                 1060                 1065             


Glu Lys  Lys Lys Lys Lys Ile  Lys Glu Asn Glu Leu  Phe Ala Asp 
    1070                 1075                 1080             


Ala Gly  Ala Lys Asn Glu Phe  Thr Ile Tyr Ser Asp  Val Lys Arg 
    1085                 1090                 1095             


Ile Lys  Trp His Asn Thr Gly  Thr Lys Arg Leu Glu  Glu Ala Glu 
    1100                 1105                 1110             


Gly Glu  Arg Leu Leu Glu Asn  Lys Asn Ser Arg Gly  Arg Asp Lys 
    1115                 1120                 1125             


Glu Tyr  Asp Ile Asn Lys Cys  Leu Thr Arg Leu Phe  Arg Glu Asn 
    1130                 1135                 1140             


Lys Ile  Asp Val Asn Gly Asp  Ile Ile Gly Gln Ile  Thr Lys Ile 
    1145                 1150                 1155             


Lys Ser  Leu Lys Leu Tyr Gln  Asp Leu Phe Tyr Tyr  Leu Phe Leu 
    1160                 1165                 1170             


Ala Thr  Leu Ile Arg Asn Asn  Val Ser Gly Ser Asp  Ile Asp Tyr 
    1175                 1180                 1185             


Ile Gln  Cys Pro Ser Cys His  Phe His Ser Asp Gly  Gly Phe Gln 
    1190                 1195                 1200             


Lys Gln  Lys Phe Asn Gly Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1205                 1210                 1215             


Arg Lys  Gly Ile Leu Ile Leu  Lys Lys Ile Lys Gln  Phe Ala Ala 
    1220                 1225                 1230             


Gln Asp  Lys Asp Met Lys Asn  Phe Gly Trp Lys His  Leu Thr Val 
    1235                 1240                 1245             


Asp Ile  Asn Glu Trp Asp Lys  Phe Thr Gln Lys 
    1250                 1255                 


<210>  70
<211>  1371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  70

Met Asn Lys Asn Phe Ser Asn Phe Thr Glu Leu Tyr Thr Leu Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Glu Leu Lys Pro Val Ala Gln Thr Lys Glu Asn Ile 
            20                  25                  30          


Lys Lys Gly Lys Phe Leu Glu Ser Asp Lys Lys Lys Ala Asp Asp Tyr 
        35                  40                  45              


Lys Asp Val Lys Lys Ile Ile Asp Asn Tyr His Lys Phe Phe Ile Asp 
    50                  55                  60                  


Asp Val Leu Lys Asn Ala Ser Phe Asp Trp Thr Val Leu Glu Lys Glu 
65                  70                  75                  80  


Met Ser Asp Phe Asn Lys Ser Lys Ala Asp Asp Ser Lys Val Glu Ala 
                85                  90                  95      


Glu Gln Lys Lys Leu Arg Asp Gln Ile Ala Lys Lys Leu Thr Ser Asp 
            100                 105                 110         


Lys Arg Phe Lys Ala Leu Thr Ala Ser Thr Pro Ser Asp Leu Phe Asn 
        115                 120                 125             


Lys Asp Lys Asp Phe Ile Asp Trp Phe Thr Gln Asn Ser Thr Lys Asp 
    130                 135                 140                 


Ile Asn Lys Glu Ala Leu Glu Thr Phe Lys Arg Phe Ser Ser Tyr Phe 
145                 150                 155                 160 


Lys Gly Phe Gln Glu Asn Arg Lys Asn Val Tyr Ser Ala Glu Pro Ile 
                165                 170                 175     


Pro Thr Ala Val Pro Tyr Arg Leu Val Asn Asp Asn Phe Pro Lys Phe 
            180                 185                 190         


Leu Gln Asn Ile Ala Leu Phe Lys Ile Ile Gln Glu Lys Cys Pro Gln 
        195                 200                 205             


Val Ile Ser Asp Val Glu Lys Glu Leu Ala Ser Tyr Leu Gly Lys Glu 
    210                 215                 220                 


Lys Leu Ala Asp Ile Phe Thr Val Gln Ala Phe Asn Lys Tyr Leu Cys 
225                 230                 235                 240 


Gln Gly Gly Lys Glu Asn Gln Arg Gly Ile Asp Phe Tyr Asn Asn Ile 
                245                 250                 255     


Leu Gly Gly Ile Ala Glu Lys Glu Gly Gly Ile Asn Leu Arg Gly Ile 
            260                 265                 270         


Asn Gln Phe Leu Asn Leu Tyr Trp Gln Gln His Gln Asp Phe Ala Lys 
        275                 280                 285             


Gln Asn Lys Arg Ile Lys Met Ile Pro Leu Phe Lys Gln Ile Leu Ser 
    290                 295                 300                 


Asp Arg Ser Ser Leu Ser Phe Lys Ile Glu Ser Ile Asn Thr Asp Gln 
305                 310                 315                 320 


Glu Leu Leu Thr Ser Ile Thr Glu Tyr Ala Asp Lys Leu Glu Thr Lys 
                325                 330                 335     


Ser Asn Asp Glu Lys Lys Ser Val Leu Asp Ile Cys Ser Asp Leu Phe 
            340                 345                 350         


Ala Ser Ile Lys Ala Gln Asn Leu Gln Glu Ile Tyr Val Asn Arg Lys 
        355                 360                 365             


Asp Ile Asn Ser Ile Ser Arg Ile Leu Thr Gly Asp Trp Ser Trp Leu 
    370                 375                 380                 


Gln Ser Arg Met Asn Val Tyr Ala Asp Glu Val Phe Thr Thr Lys Ala 
385                 390                 395                 400 


Glu Lys Thr Arg Trp Gln Lys Ser Ile Asp Gly Asp Glu Gly Glu Asn 
                405                 410                 415     


Lys Ser Lys Gly Val Phe Ser Leu Ala Glu Leu Asn Ser Val Leu Glu 
            420                 425                 430         


Tyr Ser Ser Glu Asn Val Ser Glu Thr Asp Val Arg Ile Thr Asp Phe 
        435                 440                 445             


Phe Asp His Arg Asn Arg Phe Tyr Tyr Glu Lys Glu Ser Gly Leu Phe 
    450                 455                 460                 


Lys Gln Gly Asp Glu Leu Val Ala Leu Ser Ile Arg Glu Ser Cys Glu 
465                 470                 475                 480 


Asp Ile Leu Ala Lys Arg Lys Ala Met Asp Glu Ala Phe Ala Asn Val 
                485                 490                 495     


Ser Glu Asn Asn Ser Leu Arg Asp Asn Ser Glu Asp Val Ala Lys Ile 
            500                 505                 510         


Lys Ile Tyr Leu Asp Cys Val Gln Glu Leu Leu His Arg Ile Lys Pro 
        515                 520                 525             


Leu Lys Val Asn Gly Leu Gly Asp Pro Ala Phe Tyr Ala Val Phe Asp 
    530                 535                 540                 


Thr Val Tyr Asn Ser Leu Ser Glu Val Ile Ser Leu Tyr Asn Lys Thr 
545                 550                 555                 560 


Arg Asn Tyr Ile Thr Lys Lys Ala Ala Asn Pro Glu Lys Tyr Lys Leu 
                565                 570                 575     


Asn Phe Asp Asn Pro Thr Leu Ala Asp Gly Trp Asp Leu Asn Lys Glu 
            580                 585                 590         


Gln Ala Asn Thr Ser Val Leu Met Arg Lys Asp Gly Met Tyr Tyr Leu 
        595                 600                 605             


Gly Ile Met Asn Pro Lys Asp Lys Pro Lys Phe Ala Glu Lys Tyr Glu 
    610                 615                 620                 


Cys Gly Asn Glu Ala Cys Tyr Glu Lys Met Ile Tyr Lys Gln Phe Asp 
625                 630                 635                 640 


Ala Thr Lys Gln Ile Pro Lys Cys Ser Thr Gln Val Lys Glu Val Lys 
                645                 650                 655     


Lys His Phe Gln Ser Gly Ala Thr Asp Ser Ile Ile Leu Asn Asp Lys 
            660                 665                 670         


Ser Lys Phe Lys Leu Asp Leu Val Ile Thr Lys Glu Ile Trp Phe Leu 
        675                 680                 685             


Asn Asn His Val Trp Asn Gly Glu Lys Phe Val Pro Lys Arg Glu Ser 
    690                 695                 700                 


Asn Glu Thr Arg Pro Lys Lys Phe Gln Ile Gly Tyr Tyr Lys Gln Thr 
705                 710                 715                 720 


Gly Asp Leu Gly Gly Tyr Lys Glu Ala Leu Asn Ile Trp Ile Ser Phe 
                725                 730                 735     


Cys Lys Thr Phe Leu Gln Ser Tyr Ile Ser Ser Ser Ile Tyr Asp Tyr 
            740                 745                 750         


Asp Phe Lys Glu Ser Ser Asn Tyr Asp Ser Leu Asp Glu Phe Tyr Asn 
        755                 760                 765             


Tyr Leu Asn Ala Thr Cys Tyr Lys Leu Ser Phe Ile Asn Ile Pro Glu 
    770                 775                 780                 


Ala Thr Ile Ser Gln Met Val Ser Glu Gly Lys Leu Tyr Leu Phe Gln 
785                 790                 795                 800 


Ile Tyr Asn Lys Asp Phe Ala Pro Gly Ala Ser Gly Met Pro Asn Met 
                805                 810                 815     


His Thr Leu Tyr Trp Lys Asn Leu Phe Ser Glu Glu Asn Leu Lys Asn 
            820                 825                 830         


Val Val Leu Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr Arg Pro Ala 
        835                 840                 845             


Gly Ile Lys Glu Pro Val Ile His Ala Lys Gly Ser Tyr Leu Val Asn 
    850                 855                 860                 


Arg Ile Thr Lys Asp Gly Glu Pro Ile Pro Glu Lys Ile His Asp Glu 
865                 870                 875                 880 


Ile Tyr Arg Asn Ala Asn Gly Lys Leu Glu Ser Leu Ser Lys Glu Ala 
                885                 890                 895     


Thr Glu Tyr Lys Ala Ser His Lys Val Val Ile Lys Glu Ala Lys His 
            900                 905                 910         


Asp Ile Ile Lys Asp Arg His Tyr Thr Glu Pro Lys Phe Leu Phe His 
        915                 920                 925             


Val Pro Leu Thr Ile Asn Phe Lys Ala Ser Gly Asn Ser Tyr Ile Asn 
    930                 935                 940                 


Glu Asn Val Arg Arg Phe Leu Lys Asn Asn Pro Asp Val Asn Val Ile 
945                 950                 955                 960 


Gly Leu Asp Arg Gly Glu Arg His Leu Ile Tyr Leu Ser Leu Ile Asn 
                965                 970                 975     


Gln Lys Gly Glu Ile Ile Lys Gln Phe Thr Phe Asn Glu Val Glu Arg 
            980                 985                 990         


Asn Lys Asn Gly Gln Val Ile Lys  Val Asn Tyr His Glu  Lys Leu Asp 
        995                 1000                 1005             


Gln Arg  Glu Lys Val Arg Gly  Ala Ala Arg Lys Ser  Trp Gln Ala 
    1010                 1015                 1020             


Ile Gly  Lys Ile Ala Glu Leu  Lys Glu Gly Tyr Leu  Ser Ala Val 
    1025                 1030                 1035             


Ile His  Gln Leu Thr Lys Leu  Met Val Glu Tyr Asn  Ala Ile Val 
    1040                 1045                 1050             


Val Met  Glu Asp Leu Asn Phe  Gly Phe Lys Arg Gly  Arg Phe His 
    1055                 1060                 1065             


Val Glu  Lys Gln Val Tyr Gln  Lys Phe Glu His Met  Leu Ile Asp 
    1070                 1075                 1080             


Lys Leu  Asn Tyr Leu Val Phe  Lys Asp Arg Gly Leu  Thr Glu Ala 
    1085                 1090                 1095             


Gly Gly  Val Leu Asn Gly Tyr  Gln Leu Ala Gly Gln  Phe Glu Ser 
    1100                 1105                 1110             


Phe Gln  Lys Leu Gly Lys Gln  Ser Gly Met Leu Phe  Tyr Val Pro 
    1115                 1120                 1125             


Ala Gly  Tyr Thr Ser Lys Ile  Asp Pro Lys Thr Gly  Phe Ala Ser 
    1130                 1135                 1140             


Met Ser  Asn Phe Lys Asp Leu  Thr Asn Val His Lys  Lys Arg Ala 
    1145                 1150                 1155             


Phe Phe  Ser Lys Phe Asp Asp  Ile His Phe Asp Asp  Ala Thr Gly 
    1160                 1165                 1170             


Ser Phe  Val Phe Thr Phe Asp  Tyr Lys Asn Phe Asp  Gly Lys Ala 
    1175                 1180                 1185             


Lys Glu  Glu Met Lys Arg Thr  Lys Trp Ser Val Tyr  Ser Lys Asp 
    1190                 1195                 1200             


Lys Arg  Ile Val Tyr Leu Ser  Lys Thr Lys Ser Tyr  Glu Asp Val 
    1205                 1210                 1215             


Gln Pro  Thr Glu Lys Ile Lys  Ala Ser Leu Glu Ser  Val Gly Ile 
    1220                 1225                 1230             


Glu Tyr  Met Ser Gly Asn Asn  Leu Ile Asp Ser Ile  Met Val Ile 
    1235                 1240                 1245             


Gly Ala  Glu Leu Lys Asp Gly  Ala Lys Pro Ser Lys  Glu Ile Ala 
    1250                 1255                 1260             


Asp Phe  Trp Asp Arg Leu Leu  Tyr Asn Phe Lys Leu  Ile Leu Gln 
    1265                 1270                 1275             


Met Arg  Asn Ser Asn Ala Lys  Thr Gly Glu Asp Tyr  Ile Ile Ser 
    1280                 1285                 1290             


Pro Val  Met Ala Asp Asp Gly  Thr Phe Phe Asp Ser  Arg Glu Glu 
    1295                 1300                 1305             


Phe Lys  Lys Gly Glu Asn Ala  Lys Met Pro Val Asp  Ala Asp Ala 
    1310                 1315                 1320             


Asn Gly  Ala Tyr His Ile Ala  Leu Lys Gly Leu Ser  Leu Leu Lys 
    1325                 1330                 1335             


Arg Phe  Asp Ala Ala Ser Glu  Asn Glu Leu Lys Lys  Phe Asp Met 
    1340                 1345                 1350             


Lys Ile  Ser Asn Val Asp Trp  Phe Lys Phe Ala Gln  Glu Lys Ser 
    1355                 1360                 1365             


Tyr Ala  Glu 
    1370     


<210>  71
<211>  1160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  71

Met Lys Ala Lys Lys Ser Phe Tyr Asn Gln Lys Arg Lys Phe Gly Lys 
1               5                   10                  15      


Arg Gly Tyr Arg Leu His Asp Glu Arg Ile Ala Tyr Ser Gly Gly Ile 
            20                  25                  30          


Gly Ser Met Arg Ser Ile Lys Tyr Glu Leu Lys Asp Ser Tyr Gly Ile 
        35                  40                  45              


Ala Gly Leu Arg Asn Arg Ile Ala Asp Ala Thr Ile Ser Asp Asn Lys 
    50                  55                  60                  


Trp Leu Tyr Gly Asn Ile Asn Leu Asn Asp Tyr Leu Glu Trp Arg Ser 
65                  70                  75                  80  


Ser Lys Thr Asp Lys Gln Ile Glu Asp Gly Asp Arg Glu Ser Ser Leu 
                85                  90                  95      


Leu Gly Phe Trp Leu Glu Ala Leu Arg Leu Gly Phe Val Phe Ser Lys 
            100                 105                 110         


Gln Ser His Ala Pro Asn Asp Phe Asn Glu Thr Ala Leu Gln Asp Leu 
        115                 120                 125             


Phe Glu Thr Leu Asp Asp Asp Leu Lys His Val Leu Asp Arg Lys Lys 
    130                 135                 140                 


Trp Cys Asp Phe Ile Lys Ile Gly Thr Pro Lys Thr Asn Asp Gln Gly 
145                 150                 155                 160 


Arg Leu Lys Lys Gln Ile Lys Asn Leu Leu Lys Gly Asn Lys Arg Glu 
                165                 170                 175     


Glu Ile Glu Lys Thr Leu Asn Glu Ser Asp Asp Glu Leu Lys Glu Lys 
            180                 185                 190         


Ile Asn Arg Ile Ala Asp Val Phe Ala Lys Asn Lys Ser Asp Lys Tyr 
        195                 200                 205             


Thr Ile Phe Lys Leu Asp Lys Pro Asn Thr Glu Lys Tyr Pro Arg Ile 
    210                 215                 220                 


Asn Asp Val Gln Val Ala Phe Phe Cys His Pro Asp Phe Glu Glu Ile 
225                 230                 235                 240 


Thr Glu Arg Asp Arg Thr Lys Thr Leu Asp Leu Ile Ile Asn Arg Phe 
                245                 250                 255     


Asn Lys Arg Tyr Glu Ile Thr Glu Asn Lys Lys Asp Asp Lys Thr Ser 
            260                 265                 270         


Asn Arg Met Ala Leu Tyr Ser Leu Asn Gln Gly Tyr Ile Pro Arg Val 
        275                 280                 285             


Leu Asn Asp Leu Phe Leu Phe Val Lys Asp Asn Glu Asp Asp Phe Ser 
    290                 295                 300                 


Gln Phe Leu Ser Asp Leu Glu Asn Phe Phe Ser Phe Ser Asn Glu Gln 
305                 310                 315                 320 


Ile Lys Ile Ile Lys Glu Arg Leu Lys Lys Leu Lys Lys Tyr Ala Glu 
                325                 330                 335     


Pro Ile Pro Gly Lys Pro Gln Leu Ala Asp Lys Trp Asp Asp Tyr Ala 
            340                 345                 350         


Ser Asp Phe Gly Gly Lys Leu Glu Ser Trp Tyr Ser Asn Arg Ile Glu 
        355                 360                 365             


Lys Leu Lys Lys Ile Pro Glu Ser Val Ser Asp Leu Arg Asn Asn Leu 
    370                 375                 380                 


Glu Lys Ile Arg Asn Val Leu Lys Lys Gln Asn Asn Ala Ser Lys Ile 
385                 390                 395                 400 


Leu Glu Leu Ser Gln Lys Ile Ile Glu Tyr Ile Arg Asp Tyr Gly Val 
                405                 410                 415     


Ser Phe Glu Lys Pro Glu Ile Ile Lys Phe Ser Trp Ile Asn Lys Thr 
            420                 425                 430         


Lys Asp Gly Gln Lys Lys Val Phe Tyr Val Ala Lys Met Ala Asp Arg 
        435                 440                 445             


Glu Phe Ile Glu Lys Leu Asp Leu Trp Met Ala Asp Leu Arg Ser Gln 
    450                 455                 460                 


Leu Asn Glu Tyr Asn Gln Asp Asn Lys Val Ser Phe Lys Lys Lys Gly 
465                 470                 475                 480 


Lys Lys Ile Glu Glu Leu Gly Val Leu Asp Phe Ala Leu Asn Lys Ala 
                485                 490                 495     


Lys Lys Asn Lys Ser Thr Lys Asn Glu Asn Gly Trp Gln Gln Lys Leu 
            500                 505                 510         


Ser Glu Ser Ile Gln Ser Ala Pro Leu Phe Phe Gly Glu Gly Asn Arg 
        515                 520                 525             


Val Arg Asn Glu Glu Val Tyr Asn Leu Lys Asp Leu Leu Phe Ser Glu 
    530                 535                 540                 


Ile Lys Asn Val Glu Asn Ile Leu Met Ser Ser Glu Ala Glu Asp Leu 
545                 550                 555                 560 


Lys Asn Ile Lys Ile Glu Tyr Lys Glu Asp Gly Ala Lys Lys Gly Asn 
                565                 570                 575     


Tyr Val Leu Asn Val Leu Ala Arg Phe Tyr Ala Arg Phe Asn Glu Asp 
            580                 585                 590         


Gly Tyr Gly Gly Trp Asn Lys Val Lys Thr Val Leu Glu Asn Ile Ala 
        595                 600                 605             


Arg Glu Ala Gly Thr Asp Phe Ser Lys Tyr Gly Asn Asn Asn Asn Arg 
    610                 615                 620                 


Asn Ala Gly Arg Phe Tyr Leu Asn Gly Arg Glu Arg Gln Val Phe Thr 
625                 630                 635                 640 


Leu Ile Lys Phe Glu Lys Ser Ile Thr Val Glu Lys Ile Leu Glu Leu 
                645                 650                 655     


Val Lys Leu Pro Ser Leu Leu Asp Glu Ala Tyr Arg Asp Leu Val Asn 
            660                 665                 670         


Glu Asn Lys Asn His Lys Leu Arg Asp Val Ile Gln Leu Ser Lys Thr 
        675                 680                 685             


Ile Met Ala Leu Val Leu Ser His Ser Asp Lys Glu Lys Gln Ile Gly 
    690                 695                 700                 


Gly Asn Tyr Ile His Ser Lys Leu Ser Gly Tyr Asn Ala Leu Ile Ser 
705                 710                 715                 720 


Lys Arg Asp Phe Ile Ser Arg Tyr Ser Val Gln Thr Thr Asn Gly Thr 
                725                 730                 735     


Gln Cys Lys Leu Ala Ile Gly Lys Gly Lys Ser Lys Lys Gly Asn Glu 
            740                 745                 750         


Ile Asp Arg Tyr Phe Tyr Ala Phe Gln Phe Phe Lys Asn Asp Asp Ser 
        755                 760                 765             


Lys Ile Asn Leu Lys Val Ile Lys Asn Asn Ser His Lys Asn Ile Asp 
    770                 775                 780                 


Phe Asn Asp Asn Glu Asn Lys Ile Asn Ala Leu Gln Val Tyr Ser Ser 
785                 790                 795                 800 


Asn Tyr Gln Ile Gln Phe Leu Asp Trp Phe Phe Glu Lys His Gln Gly 
                805                 810                 815     


Lys Lys Thr Ser Leu Glu Val Gly Gly Ser Phe Thr Ile Ala Glu Lys 
            820                 825                 830         


Ser Leu Thr Ile Asp Trp Ser Gly Ser Asn Pro Arg Val Gly Phe Lys 
        835                 840                 845             


Arg Ser Asp Thr Glu Glu Lys Arg Val Phe Val Ser Gln Pro Phe Thr 
    850                 855                 860                 


Leu Ile Pro Asp Asp Glu Asp Lys Glu Arg Arg Lys Glu Arg Met Ile 
865                 870                 875                 880 


Lys Thr Lys Asn Arg Phe Ile Gly Ile Asp Ile Gly Glu Tyr Gly Leu 
                885                 890                 895     


Ala Trp Ser Leu Ile Glu Val Asp Asn Gly Asp Lys Asn Asn Arg Gly 
            900                 905                 910         


Ile Arg Gln Leu Glu Ser Gly Phe Ile Thr Asp Asn Gln Gln Gln Val 
        915                 920                 925             


Leu Lys Lys Asn Val Lys Ser Trp Arg Gln Asn Gln Ile Arg Gln Thr 
    930                 935                 940                 


Phe Thr Ser Pro Asp Thr Lys Ile Ala Arg Leu Arg Glu Ser Leu Ile 
945                 950                 955                 960 


Gly Ser Tyr Lys Asn Gln Leu Glu Ser Leu Met Val Ala Lys Lys Ala 
                965                 970                 975     


Asn Leu Ser Phe Glu Tyr Glu Val Ser Gly Phe Glu Val Gly Gly Lys 
            980                 985                 990         


Arg Val Ala Lys Ile Tyr Asp Ser  Ile Lys Arg Gly Ser  Val Arg Lys 
        995                 1000                 1005             


Lys Asp  Asn Asn Ser Gln Asn  Asp Gln Ser Trp Gly  Lys Lys Gly 
    1010                 1015                 1020             


Ile Asn  Glu Trp Ser Phe Glu  Thr Thr Ala Ala Gly  Thr Ser Gln 
    1025                 1030                 1035             


Phe Cys  Thr His Cys Lys Arg  Trp Ser Ser Leu Ala  Ile Val Asp 
    1040                 1045                 1050             


Ile Glu  Glu Tyr Glu Leu Lys  Asp Tyr Asn Asp Asn  Leu Phe Lys 
    1055                 1060                 1065             


Val Lys  Ile Asn Asp Gly Glu  Val Arg Leu Leu Gly  Lys Lys Gly 
    1070                 1075                 1080             


Trp Arg  Ser Gly Glu Lys Ile  Lys Gly Lys Glu Leu  Phe Gly Pro 
    1085                 1090                 1095             


Val Lys  Asp Ala Met Arg Pro  Asn Val Asp Gly Leu  Gly Met Lys 
    1100                 1105                 1110             


Ile Val  Lys Arg Lys Tyr Leu  Lys Leu Asp Leu Arg  Asp Trp Val 
    1115                 1120                 1125             


Ser Arg  Tyr Gly Asn Met Ala  Ile Phe Ile Cys Pro  Tyr Val Asp 
    1130                 1135                 1140             


Cys His  His Ile Ser His Ala  Asp Lys Gln Ala Ala  Phe Asn Ile 
    1145                 1150                 1155             


Ala Val  
    1160 


<210>  72
<211>  1285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  72

Met Lys Leu Thr Arg Arg Arg Ile Ser Gly Asn Ser Val Asp Gln Lys 
1               5                   10                  15      


Ile Thr Ala Ala Phe Tyr Arg Asp Met Ser Gln Gly Leu Leu Tyr Tyr 
            20                  25                  30          


Asp Ser Glu Asp Asn Asp Cys Thr Asp Lys Val Ile Glu Ser Met Asp 
        35                  40                  45              


Phe Glu Arg Ser Trp Arg Gly Arg Ile Leu Lys Asn Gly Glu Asp Asp 
    50                  55                  60                  


Lys Asn Pro Phe Tyr Met Phe Val Lys Gly Leu Val Gly Ser Asn Asp 
65                  70                  75                  80  


Lys Ile Val Cys Glu Pro Ile Asp Val Asp Ser Asp Pro Asp Asn Leu 
                85                  90                  95      


Asp Ile Leu Ile Asn Lys Asn Leu Thr Gly Phe Gly Arg Asn Leu Lys 
            100                 105                 110         


Ala Pro Asp Ser Asn Asp Thr Leu Glu Asn Leu Ile Arg Lys Ile Gln 
        115                 120                 125             


Ala Gly Ile Pro Glu Glu Glu Val Leu Pro Glu Leu Lys Lys Ile Lys 
    130                 135                 140                 


Glu Met Ile Gln Lys Asp Ile Val Asn Arg Lys Glu Gln Leu Leu Lys 
145                 150                 155                 160 


Ser Ile Lys Asn Asn Arg Ile Pro Phe Ser Leu Glu Gly Ser Lys Leu 
                165                 170                 175     


Val Pro Ser Thr Lys Lys Met Lys Trp Leu Phe Lys Leu Ile Asp Val 
            180                 185                 190         


Pro Asn Lys Thr Phe Asn Glu Lys Met Leu Glu Lys Tyr Trp Glu Ile 
        195                 200                 205             


Tyr Asp Tyr Asp Lys Leu Lys Ala Asn Ile Thr Asn Arg Leu Asp Lys 
    210                 215                 220                 


Thr Asp Lys Lys Ala Arg Ser Ile Ser Arg Ala Val Ser Glu Glu Leu 
225                 230                 235                 240 


Arg Glu Tyr His Lys Asn Leu Arg Thr Asn Tyr Asn Arg Phe Val Ser 
                245                 250                 255     


Gly Asp Arg Pro Ala Ala Gly Leu Asp Asn Gly Gly Ser Ala Lys Tyr 
            260                 265                 270         


Asn Pro Asp Lys Glu Glu Phe Leu Leu Phe Leu Lys Glu Val Glu Gln 
        275                 280                 285             


Tyr Phe Lys Lys Tyr Phe Pro Val Lys Ser Lys His Ser Asn Lys Ser 
    290                 295                 300                 


Lys Asp Lys Ser Leu Val Asp Lys Tyr Lys Asn Tyr Cys Ser Tyr Lys 
305                 310                 315                 320 


Val Val Lys Lys Glu Val Asn Arg Ser Ile Ile Asn Gln Leu Val Ala 
                325                 330                 335     


Gly Leu Ile Gln Gln Gly Lys Leu Leu Tyr Tyr Phe Tyr Tyr Asn Asp 
            340                 345                 350         


Thr Trp Gln Glu Asp Phe Leu Asn Ser Tyr Gly Leu Ser Tyr Ile Gln 
        355                 360                 365             


Val Glu Glu Ala Phe Lys Lys Ser Val Met Thr Ser Leu Ser Trp Gly 
    370                 375                 380                 


Ile Asn Arg Leu Thr Ser Phe Phe Ile Asp Asp Ser Asn Thr Val Lys 
385                 390                 395                 400 


Phe Asp Asp Ile Thr Thr Lys Lys Ala Lys Glu Ala Ile Glu Ser Asn 
                405                 410                 415     


Tyr Phe Asn Lys Leu Arg Thr Cys Ser Arg Met Gln Asp His Phe Lys 
            420                 425                 430         


Glu Lys Leu Ala Phe Phe Tyr Pro Val Tyr Val Lys Asp Lys Lys Asp 
        435                 440                 445             


Arg Pro Asp Asp Asp Ile Glu Asn Leu Ile Val Leu Val Lys Asn Ala 
    450                 455                 460                 


Ile Glu Ser Val Ser Tyr Leu Arg Asn Arg Thr Phe His Phe Lys Glu 
465                 470                 475                 480 


Ser Ser Leu Leu Glu Leu Leu Lys Glu Leu Asp Asp Lys Asn Ser Gly 
                485                 490                 495     


Gln Asn Lys Ile Asp Tyr Ser Val Ala Ala Glu Phe Ile Lys Arg Asp 
            500                 505                 510         


Ile Glu Asn Leu Tyr Asp Val Phe Arg Glu Gln Ile Arg Ser Leu Gly 
        515                 520                 525             


Ile Ala Glu Tyr Tyr Lys Ala Asp Met Ile Ser Asp Cys Phe Lys Thr 
    530                 535                 540                 


Cys Gly Leu Glu Phe Ala Leu Tyr Ser Pro Lys Asn Ser Leu Met Pro 
545                 550                 555                 560 


Ala Phe Lys Asn Val Tyr Lys Arg Gly Ala Asn Leu Asn Lys Ala Tyr 
                565                 570                 575     


Ile Arg Asp Lys Gly Pro Lys Glu Thr Gly Asp Gln Gly Gln Asn Ser 
            580                 585                 590         


Tyr Lys Ala Leu Glu Glu Tyr Arg Glu Leu Thr Trp Tyr Ile Glu Val 
        595                 600                 605             


Lys Asn Asn Asp Gln Ser Tyr Asn Ala Tyr Lys Asn Leu Leu Gln Leu 
    610                 615                 620                 


Ile Tyr Tyr His Ala Phe Leu Pro Glu Val Arg Glu Asn Glu Ala Leu 
625                 630                 635                 640 


Ile Thr Asp Phe Ile Asn Arg Thr Lys Glu Trp Asn Arg Lys Glu Thr 
                645                 650                 655     


Glu Glu Arg Leu Asn Thr Lys Asn Asn Lys Lys His Lys Asn Phe Asp 
            660                 665                 670         


Glu Asn Asp Asp Ile Thr Val Asn Thr Tyr Arg Tyr Glu Ser Ile Pro 
        675                 680                 685             


Asp Tyr Gln Gly Glu Ser Leu Asp Asp Tyr Leu Lys Val Leu Gln Arg 
    690                 695                 700                 


Lys Gln Met Ala Arg Ala Lys Glu Val Asn Glu Lys Glu Glu Gly Asn 
705                 710                 715                 720 


Asn Asn Tyr Ile Gln Phe Ile Arg Asp Val Val Val Trp Ala Phe Gly 
                725                 730                 735     


Ala Tyr Leu Glu Asn Lys Leu Lys Asn Tyr Lys Asn Glu Leu Gln Pro 
            740                 745                 750         


Pro Leu Ser Lys Glu Asn Ile Gly Leu Asn Asp Thr Leu Lys Glu Leu 
        755                 760                 765             


Phe Pro Glu Glu Lys Val Lys Ser Pro Phe Asn Ile Lys Cys Arg Phe 
    770                 775                 780                 


Ser Ile Ser Thr Phe Ile Asp Asn Lys Gly Lys Ser Thr Asp Asn Thr 
785                 790                 795                 800 


Ser Ala Glu Ala Val Lys Thr Asp Gly Lys Glu Asp Glu Lys Asp Lys 
                805                 810                 815     


Lys Asn Ile Lys Arg Lys Asp Leu Leu Cys Phe Tyr Leu Phe Leu Arg 
            820                 825                 830         


Leu Leu Asp Glu Asn Glu Ile Cys Lys Leu Gln His Gln Phe Ile Lys 
        835                 840                 845             


Tyr Arg Cys Ser Leu Lys Glu Arg Arg Phe Pro Gly Asn Arg Thr Lys 
    850                 855                 860                 


Leu Glu Lys Glu Thr Glu Leu Leu Ala Glu Leu Glu Glu Leu Met Glu 
865                 870                 875                 880 


Leu Val Arg Phe Thr Met Pro Ser Ile Pro Glu Ile Ser Ala Lys Ala 
                885                 890                 895     


Glu Ser Gly Tyr Asp Thr Met Ile Lys Lys Tyr Phe Lys Asp Phe Ile 
            900                 905                 910         


Glu Lys Lys Val Phe Lys Asn Pro Lys Thr Ser Asn Leu Tyr Tyr His 
        915                 920                 925             


Ser Asp Ser Lys Thr Pro Val Thr Arg Lys Tyr Met Ala Leu Leu Met 
    930                 935                 940                 


Arg Ser Ala Pro Leu His Leu Tyr Lys Asp Ile Phe Lys Gly Tyr Tyr 
945                 950                 955                 960 


Leu Ile Thr Lys Lys Glu Cys Leu Glu Tyr Ile Lys Leu Ser Asn Ile 
                965                 970                 975     


Ile Lys Asp Tyr Gln Asn Ser Leu Asn Glu Leu His Glu Gln Leu Glu 
            980                 985                 990         


Arg Ile Lys Leu Lys Ser Glu Lys  Gln Asn Gly Lys Asp  Ser Leu Tyr 
        995                 1000                 1005             


Leu Asp  Lys Lys Asp Phe Tyr  Lys Val Lys Glu Tyr  Val Glu Asn 
    1010                 1015                 1020             


Leu Glu  Gln Val Ala Arg Tyr  Lys His Leu Gln His  Lys Ile Asn 
    1025                 1030                 1035             


Phe Glu  Ser Leu Tyr Arg Ile  Phe Arg Ile His Val  Asp Ile Ala 
    1040                 1045                 1050             


Ala Arg  Met Val Gly Tyr Thr  Gln Asp Trp Glu Arg  Asp Met His 
    1055                 1060                 1065             


Phe Leu  Phe Lys Ala Leu Val  Tyr Asn Gly Val Leu  Glu Glu Arg 
    1070                 1075                 1080             


Arg Phe  Glu Ala Ile Phe Asn  Asn Asn Asp Asp Asn  Asn Asp Gly 
    1085                 1090                 1095             


Arg Ile  Val Lys Lys Ile Gln  Asn Asn Leu Asn Asn  Lys Asn Arg 
    1100                 1105                 1110             


Glu Leu  Val Ser Met Leu Cys  Trp Asn Lys Lys Leu  Asn Lys Asn 
    1115                 1120                 1125             


Glu Phe  Gly Ala Ile Ile Trp  Lys Arg Asn Pro Ile  Ala His Leu 
    1130                 1135                 1140             


Asn His  Phe Thr Gln Thr Glu  Gln Asn Ser Lys Ser  Ser Leu Glu 
    1145                 1150                 1155             


Ser Leu  Ile Asn Ser Leu Arg  Ile Leu Leu Ala Tyr  Asp Arg Lys 
    1160                 1165                 1170             


Arg Gln  Asn Ala Val Thr Lys  Thr Ile Asn Asp Leu  Leu Leu Asn 
    1175                 1180                 1185             


Asp Tyr  His Ile Arg Ile Lys  Trp Glu Gly Arg Val  Asp Glu Gly 
    1190                 1195                 1200             


Gln Ile  Tyr Phe Asn Ile Lys  Glu Lys Glu Asp Ile  Glu Asn Glu 
    1205                 1210                 1215             


Pro Ile  Ile His Leu Lys His  Leu His Lys Lys Asp  Cys Tyr Ile 
    1220                 1225                 1230             


Tyr Lys  Asn Ser Tyr Met Phe  Asp Lys Gln Lys Glu  Trp Ile Cys 
    1235                 1240                 1245             


Asn Gly  Ile Lys Glu Glu Val  Tyr Asp Lys Ser Ile  Leu Lys Cys 
    1250                 1255                 1260             


Ile Gly  Asn Leu Phe Lys Phe  Asp Tyr Glu Asp Lys  Asn Lys Ser 
    1265                 1270                 1275             


Ser Ala  Asn Pro Lys His Thr  
    1280                 1285 


<210>  73
<211>  1344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  73

Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr Asn Val Phe Asn 
1               5                   10                  15      


Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn Asn Asp Glu Lys 
            20                  25                  30          


Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln Lys Asn Ile Lys 
        35                  40                  45              


Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys Tyr Val Glu Ser 
    50                  55                  60                  


Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser Tyr Arg Lys Ala 
65                  70                  75                  80  


Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp Ile Leu Lys Lys 
                85                  90                  95      


Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly Gly Lys Leu Glu 
            100                 105                 110         


Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val Val Ser Lys Tyr 
        115                 120                 125             


Asp Thr Gln Glu Phe Asp Ser Leu Ala Ala Met Val Val Phe Leu Glu 
    130                 135                 140                 


Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg Glu Ile Val Cys 
145                 150                 155                 160 


Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys Leu Asp Pro Asn 
                165                 170                 175     


Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser Val Arg Asn Gln 
            180                 185                 190         


Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu Phe Pro Gln Val 
        195                 200                 205             


Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn Val Glu Lys Glu 
    210                 215                 220                 


Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu Asp Asp Glu Lys 
225                 230                 235                 240 


Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu Asp Val Tyr Phe 
                245                 250                 255     


Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile Thr Leu Ser Asp 
            260                 265                 270         


Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys His Glu Cys Gly 
        275                 280                 285             


Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp Val Leu Met Glu 
    290                 295                 300                 


Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val Glu Lys Arg Glu 
305                 310                 315                 320 


Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn Ile Ile Cys Tyr 
                325                 330                 335     


Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser Asn Glu Pro Leu 
            340                 345                 350         


Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile His His Ile Glu 
        355                 360                 365             


Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala Gly Lys Leu Phe 
    370                 375                 380                 


Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp Lys Asp Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys Ala Val Tyr Asn 
                405                 410                 415     


Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn Lys Glu Leu Gly 
            420                 425                 430         


Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser Phe Asp Tyr Glu 
        435                 440                 445             


Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu Ala Val Asp Ile 
    450                 455                 460                 


Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys Asp Met Ser Asn 
465                 470                 475                 480 


Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys Arg Asn Asp Ile 
                485                 490                 495     


Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser Val Ser Ala Val 
            500                 505                 510         


Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile Asn Ile Phe Lys 
        515                 520                 525             


Asp Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu Val Arg Phe Ile 
    530                 535                 540                 


Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn Glu Asn Phe His 
545                 550                 555                 560 


Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn Thr Glu Leu Phe 
                565                 570                 575     


Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu Asn Val Glu Lys 
            580                 585                 590         


Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr Gln Val Ser Glu 
        595                 600                 605             


Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser Val Ser Arg Ala 
    610                 615                 620                 


Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg Thr Ala Phe Pro 
625                 630                 635                 640 


Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro Ser Tyr Asp Ala 
                645                 650                 655     


Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu Leu Lys Glu 
            660                 665                 670         


Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala Leu Gln Leu Phe 
        675                 680                 685             


Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys Lys Gln Gln Arg 
    690                 695                 700                 


Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile Lys Ser Ala Cys 
705                 710                 715                 720 


Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr Glu Tyr Asn Gln 
                725                 730                 735     


Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn Asp Ser Ile Phe 
            740                 745                 750         


Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu Lys Lys Ala Ile 
        755                 760                 765             


Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys Asp Leu Phe Gly 
    770                 775                 780                 


Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg Glu Ile Asp Lys 
785                 790                 795                 800 


Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr Glu Ala Leu Cys 
                805                 810                 815     


Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp Tyr Ile Val Gly 
            820                 825                 830         


Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val Gly Ser Met Arg 
        835                 840                 845             


Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg Ala Ala Ser Ile 
    850                 855                 860                 


Gly Asn Glu Leu His Val Ser Val His Asp Val Glu Lys Val Glu Lys 
865                 870                 875                 880 


Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala Ser Arg Thr Ser 
                885                 890                 895     


Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp Tyr Ala Arg Tyr 
            900                 905                 910         


Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met Pro Ser Glu Tyr 
        915                 920                 925             


Ser Ala Leu Val Asp Phe Ser Asn Glu Glu Gln Ser Asp Leu Tyr Val 
    930                 935                 940                 


Asp Pro Lys Asn Pro Lys Val Asn Arg Asn Ile Val His Ser Lys Leu 
945                 950                 955                 960 


Phe Ala Ala Asp His Ile Leu Arg Asp Ile Val Glu Pro Val Ser Lys 
                965                 970                 975     


Asp Asn Ile Glu Glu Phe Tyr Ser Gln Lys Ala Glu Ile Ala Tyr Cys 
            980                 985                 990         


Lys Ile Lys Gly Lys Glu Ile Thr  Ala Glu Glu Gln Lys  Ala Val Leu 
        995                 1000                 1005             


Lys Tyr  Gln Lys Leu Lys Asn  Arg Val Glu Leu Arg  Asp Ile Val 
    1010                 1015                 1020             


Glu Tyr  Gly Glu Ile Ile Asn  Glu Leu Leu Gly Gln  Leu Ile Asn 
    1025                 1030                 1035             


Trp Ser  Phe Met Arg Glu Arg  Asp Leu Leu Tyr Phe  Gln Leu Gly 
    1040                 1045                 1050             


Phe His  Tyr Asp Cys Leu Arg  Asn Asp Ser Lys Lys  Pro Glu Gly 
    1055                 1060                 1065             


Tyr Lys  Asn Ile Lys Val Asp  Glu Asn Ser Ile Lys  Asp Ala Ile 
    1070                 1075                 1080             


Leu Tyr  Gln Ile Ile Gly Met  Tyr Val Asn Gly Val  Thr Val Tyr 
    1085                 1090                 1095             


Ala Pro  Glu Lys Asp Gly Asp  Lys Leu Lys Glu Gln  Cys Val Lys 
    1100                 1105                 1110             


Gly Gly  Val Gly Val Lys Val  Ser Ala Phe His Arg  Tyr Ser Lys 
    1115                 1120                 1125             


Tyr Leu  Gly Leu Asn Glu Lys  Thr Leu Tyr Asn Ala  Gly Leu Glu 
    1130                 1135                 1140             


Ile Phe  Glu Val Val Ala Glu  His Glu Asp Ile Ile  Asn Leu Arg 
    1145                 1150                 1155             


Asn Gly  Ile Asp His Phe Lys  Tyr Tyr Leu Gly Asp  Tyr Arg Ser 
    1160                 1165                 1170             


Met Leu  Ser Ile Tyr Ser Glu  Val Phe Asp Arg Phe  Phe Thr Tyr 
    1175                 1180                 1185             


Asp Ile  Lys Tyr Gln Lys Asn  Val Leu Asn Leu Leu  Gln Asn Ile 
    1190                 1195                 1200             


Leu Leu  Arg His Asn Val Ile  Val Glu Pro Ile Leu  Glu Ser Gly 
    1205                 1210                 1215             


Phe Lys  Thr Ile Gly Glu Gln  Thr Lys Pro Gly Ala  Lys Leu Ser 
    1220                 1225                 1230             


Ile Arg  Ser Ile Lys Ser Asp  Thr Phe Gln Tyr Lys  Val Lys Gly 
    1235                 1240                 1245             


Gly Thr  Leu Ile Thr Asp Ala  Lys Asp Glu Arg Tyr  Leu Glu Thr 
    1250                 1255                 1260             


Ile Arg  Lys Ile Leu Tyr Tyr  Ala Glu Asn Glu Glu  Asp Asn Leu 
    1265                 1270                 1275             


Lys Lys  Ser Val Val Val Thr  Asn Ala Asp Lys Tyr  Glu Lys Asn 
    1280                 1285                 1290             


Lys Glu  Ser Asp Asp Gln Asn  Lys Gln Lys Glu Lys  Lys Asn Lys 
    1295                 1300                 1305             


Asp Asn  Lys Gly Lys Lys Asn  Glu Glu Thr Lys Ser  Asp Ala Glu 
    1310                 1315                 1320             


Lys Asn  Asn Asn Glu Arg Leu  Ser Tyr Asn Pro Phe  Ala Asn Leu 
    1325                 1330                 1335             


Asn Phe  Lys Leu Ser Asn 
    1340                 


