                         SEQUENCE LISTING

<110>  KORRO BIO, INC.
       PUTTA, Mallikarjuna Reddy et al.
 
<120>  METHODS AND COMPOSITIONS FOR ADAR-MEDIATED EDITING

<130>  01249-0009-00PCT

<140>  PCT/US2022/035273
<141>  2022-06-28

<150>  US 63/216,190
<151>  2021-06-29

<160>  236   

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1
ggugaauagu auaacaauau                                                   20


<210>  2
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2
auguuguuau aguauccacc                                                   20


<210>  3
<211>  45
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
ggugaauagu auaacaauau gcuaaauguu guuauaguau ccacc                       45


<210>  4
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
ggugaagagg agaacaauau                                                   20


<210>  5
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5
auguuguucu cgucuccacc                                                   20


<210>  6
<211>  45
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6
ggugaagagg agaacaauau gcuaaauguu guucucgucu ccacc                       45


<210>  7
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
ggugucgaga agaggagaac aauau                                             25


<210>  8
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
auguuguucu cgucuccucg acacc                                             25


<210>  9
<211>  55
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acacc            55


<210>  10
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10
ggguggaaua guauaacaau au                                                22


<210>  11
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11
auguuguuau aguaucccac cu                                                22


<210>  12
<211>  49
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12
ggguggaaua guauaacaau augcuaaaug uuguuauagu aucccaccu                   49


<210>  13
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
guggaauagu auaacaauau                                                   20


<210>  14
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
auguuguuau aguaucccac                                                   20


<210>  15
<211>  45
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
guggaauagu auaacaauau gcuaaauguu guuauaguau cccac                       45


<210>  16
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16
ggugucgaga auaguauaac aauau                                             25


<210>  17
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
auguuguuau aguauccucg acacc                                             25


<210>  18
<211>  55
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18
ggugucgaga auaguauaac aauaugcuaa auguuguuau aguauccucg acacc            55


<210>  19
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
ggguggaaua guauaacaau au                                                22


<210>  20
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20
auguuguuau aguaucccac cu                                                22


<210>  21
<211>  49
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
ggguggaaua guauaacaau augcuaaaug uuguuauagu aucccaccu                   49


<210>  22
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22
ggguggaaua guauacca                                                     18


<210>  23
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23
ugguauagua ucccaccu                                                     18


<210>  24
<211>  40
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24
ggguggaaua guauaccauu cgugguauag uaucccaccu                             40


<210>  25
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25
guggguggaa uaguauacca                                                   20


<210>  26
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26
ugguauagua ucccaccuac                                                   20


<210>  27
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
guggguggaa uaguauacca uucgugguau aguaucccac cuac                        44


<210>  28
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28
uggguggaau aguauacca                                                    19


<210>  29
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29
ugguauagua ucccaccua                                                    19


<210>  30
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30
uggguggaau aguauaccau ucgugguaua guaucccacc ua                          42


<210>  31
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31
gguggaauag uauacca                                                      17


<210>  32
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32
ugguauagua ucccacc                                                      17


<210>  33
<211>  38
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33
gguggaauag uauaccauuc gugguauagu aucccacc                               38


<210>  34
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34
guggaauagu auacca                                                       16


<210>  35
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35
ugguauagua ucccac                                                       16


<210>  36
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36
guggaauagu auaccauucg ugguauagua ucccac                                 36


<210>  37
<211>  45
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37
ggugaauagu auaacaauau gcuaaauguu guuauaguau ccacc                       45


<210>  38
<211>  45
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38
ggugaagagg agaacaauau gcuaaauguu guucucgucu ccacc                       45


<210>  39
<211>  55
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acacc            55


<210>  40
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(27)
<223>  contains 2'-O-methyl and phosphorothioate internucleoside linkage
       modifications

<400>  40
ggagaagagg agaaaaagaa aggggaa                                           27


<210>  41
<211>  49
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41
ggguggaaua guauaacaau augcuaaaug uuguuauagu aucccaccu                   49


<210>  42
<211>  45
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42
guggaauagu auaacaauau gcuaaauguu guuauaguau cccac                       45


<210>  43
<211>  55
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43
ggugucgaga auaguauaac aauaugcuaa auguuguuau aguauccucg acacc            55


<210>  44
<211>  49
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44
ggguggaaua guauaacaau augcuaaaug uuguuauagu aucccaccu                   49


<210>  45
<211>  40
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45
ggguggaaua guauaccauu cgugguauag uaucccaccu                             40


<210>  46
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46
guggguggaa uaguauacca uucgugguau aguaucccac cuac                        44


<210>  47
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47
uggguggaau aguauaccau ucgugguaua guaucccacc ua                          42


<210>  48
<211>  38
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48
gguggaauag uauaccauuc gugguauagu aucccacc                               38


<210>  49
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49
guggaauagu auaccauucg ugguauagua ucccac                                 36


<210>  50
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50
acatgaggat cacccatgt                                                    19


<210>  51
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: reverse primer human Rab7a site 1

<400>  51
acacagaagg gaactagaca gt                                                22


<210>  52
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: forward primer mouse Rab7a site 1

<400>  52
acagtatcca tttattatgt aatgcttctt ag                                     32


<210>  53
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: reverse primer mouse Rab7a site 1

<400>  53
tgaaaggagc gccttctaga ac                                                22


<210>  54
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: forward primer for human/mouse Rab7a site 2

<400>  54
cttaagagcc aaaaagcttt tcatc                                             25


<210>  55
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: reverse primer for human/mouse Rab7a site 2

<400>  55
tctctttaca gaagaactca gcc                                               23


<210>  56
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB003034-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl and phosphorothioate internucleoside linkage
       modifications; contains DNA/RNA nucleotides

<400>  56
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  57
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002649-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  57
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  58
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002650-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  58
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  59
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002651-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  59
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  60
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002652-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  60
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  61
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002653-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  61
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  62
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002654-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  62
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  63
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002655-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  63
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  64
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002656-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  64
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  65
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002657-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  65
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  66
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002658-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  66
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  67
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002659-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  67
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  68
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002660-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  68
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  69
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002661-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  69
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  70
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002662-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  70
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  71
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002663-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  71
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  72
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002664-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  72
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  73
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002665-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  73
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  74
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002666-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  74
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  75
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002667-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  75
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  76
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002668-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  76
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  77
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002669-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  77
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  78
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002670-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  78
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  79
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002671-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  79
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  80
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002672-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  80
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  81
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002673-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  81
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  82
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002674-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  82
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  83
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002675-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  83
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  84
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002676-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  84
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  85
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002677-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  85
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  86
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002678-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  86
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  87
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002679-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  87
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  88
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002680-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  88
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  89
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002681-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  89
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  90
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002682-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  90
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  91
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002683-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  91
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  92
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002684-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  92
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  93
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002685-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  93
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  94
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002686-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  94
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  95
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002687-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  95
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  96
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002688-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  96
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  97
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002689-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  97
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  98
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002690-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  98
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  99
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002691-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  99
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  100
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002692-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  100
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  101
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002693-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  101
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  102
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002694-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  102
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  103
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002695-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  103
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  104
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002696-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  104
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  105
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002697-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  105
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  106
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002698-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  106
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  107
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002699-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  107
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  108
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002700-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  108
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  109
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002701-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  109
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  110
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002702-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  110
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  111
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002703-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  111
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  112
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002704-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  112
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  113
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002705-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  113
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  114
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002706-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  114
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  115
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002707-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  115
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  116
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002708-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  116
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  117
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002557-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  contains 2'-O-methyl and phosphorothioate internucleoside linkage
       modifications; contains DNA/RNA nucleotides

<400>  117
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  118
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002563-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  contains 2'-O-methyl and phosphorothioate internucleoside linkage
       modifications; contains DNA/RNA nucleotides

<400>  118
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  119
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002759-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  119
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  120
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002760-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  120
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  121
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002761-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  121
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  122
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002762-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  122
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  123
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002763-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  123
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  124
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002764-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  124
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  125
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002765-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  125
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  126
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002766-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  126
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  127
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002767-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  127
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  128
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002768-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  128
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  129
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002769-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  129
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  130
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002770-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  130
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  131
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002771-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  131
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  132
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002772-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  132
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  133
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002773-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  133
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  134
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002774-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  134
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  135
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002775-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  135
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  136
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002776-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  136
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  137
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002777-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  137
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  138
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002778-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  138
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  139
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002779-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  139
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  140
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002780-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  140
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  141
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002781-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  141
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  142
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002782-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  142
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  143
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002783-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  143
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  144
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002784-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  144
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  145
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002785-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  145
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  146
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002786-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  146
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  147
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002787-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  147
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  148
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002788-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  148
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  149
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002789-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  149
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  150
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002790-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  150
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  151
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002791-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  151
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  152
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002792-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  152
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  153
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002793-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  153
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  154
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002794-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  154
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  155
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002795-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  155
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  156
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002796-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  156
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  157
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002797-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  157
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  158
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002798-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  158
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  159
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002799-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  159
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  160
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002800-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  160
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  161
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002801-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  161
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  162
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002802-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  162
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  163
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002803-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  163
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  164
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002804-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  164
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  165
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002805-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  165
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  166
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002806-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  166
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  167
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002807-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  167
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  168
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002808-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  168
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  169
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002809-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  169
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  170
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002810-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  170
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  171
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002811-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  171
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  172
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002812-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  172
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  173
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002813-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  173
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  174
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002814-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  174
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  175
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002815-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  175
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  176
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002816-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  176
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  177
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB002817-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  177
accuaagaau accacaaccc ugaaaggagc gccuuccaga acaaagg                     47


<210>  178
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Forward primer human SERPINA1 E342K

<400>  178
acctatgatc tgaagagcgt cct                                               23


<210>  179
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Reverse primer human SERPINA1 E342K

<400>  179
ttcaatcatt aagaagacaa agggt                                             25


<210>  180
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006459-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  180
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  181
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006410-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  181
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  182
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006411-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  182
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  183
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006412-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  183
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  184
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006413-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  184
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  185
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006414-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  185
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  186
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006415-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  186
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  187
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006416-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  187
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  188
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006417-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  188
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  189
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006418-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  189
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  190
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006419-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  190
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  191
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006420-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  191
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  192
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006421-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  192
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  193
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006422-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  193
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  194
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006423-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  194
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  195
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006424-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  195
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  196
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006425-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  196
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  197
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006426-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  197
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  198
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006427-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  198
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  199
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006428-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  199
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  200
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006429-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  200
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  201
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006430-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  201
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  202
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006431-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  202
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  203
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006432-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  203
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  204
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006433-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  204
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  205
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006434-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  205
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  206
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006435-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  206
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  207
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006436-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  207
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  208
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006437-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  208
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  209
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006438-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  209
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  210
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006439-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  210
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  211
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006440-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  211
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  212
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006441-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  212
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  213
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006442-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  213
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  214
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006443-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  214
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  215
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006444-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  215
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  216
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006445-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  216
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  217
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006446-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  217
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  218
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006447-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  218
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  219
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006448-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  219
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  220
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006449-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  220
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  221
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006450-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  221
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  222
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006451-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  222
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  223
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006452-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  223
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  224
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006453-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  224
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  225
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006454-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  225
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  226
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006455-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  226
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  227
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006456-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  227
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  228
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006457-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  228
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  229
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006458-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  229
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  230
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006516-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  230
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  231
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KB006517-1


<220>
<221>  misc_feature
<223>  see specification as filed for detailed description of 
       modifications and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Contains 2'-O-methyl, phosphorothioate internucleoside linkage 
       and Fluoro modifications; contains DNA/RNA nucleotides

<400>  231
aacauggccc cagcagcuuc agucccuuuc tcgucgaugg uc                          42


<210>  232
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: peptide

<400>  232

Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      


<210>  233
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: peptide

<400>  233

Ala Ala Leu Leu Pro Val Leu Leu Ala Ala Pro 
1               5                   10      


<210>  234
<211>  13
<212>  PRT
<213>  HIV


<220>
<221>  misc_feature
<223>  HIV Tat protein

<400>  234

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  235
<211>  16
<212>  PRT
<213>  Drosophila sp.


<220>
<221>  misc_feature
<223>  Drosophila Antennapedia protein

<400>  235

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  236
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: forward primer human Rab7a site 1

<400>  236
agtgtaagaa attcttggat tatgt                                             25


