                         SEQUENCE LISTING

<110>  KORRO BIO, INC.
 
<120>  METHODS AND COMPOSITIONS FOR ADAR-MEDIATED EDITING

<130>  01249-0008-00PCT

<150>  US 63/216,206
<151>  2021-06-29

<160>  186   

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1
ggugaauagu auaacaauau                                                   20


<210>  2
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2
auguuguuau aguauccacc                                                   20


<210>  3
<211>  45
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
ggugaauagu auaacaauau gcuaaauguu guuauaguau ccacc                       45


<210>  4
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
ggugaagagg agaacaauau                                                   20


<210>  5
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5
auguuguucu cgucuccacc                                                   20


<210>  6
<211>  45
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6
ggugaagagg agaacaauau gcuaaauguu guucucgucu ccacc                       45


<210>  7
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
ggugucgaga agaggagaac aauau                                             25


<210>  8
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
auguuguucu cgucuccucg acacc                                             25


<210>  9
<211>  55
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acacc            55


<210>  10
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10
ggguggaaua guauaacaau au                                                22


<210>  11
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11
auguuguuau aguaucccac cu                                                22


<210>  12
<211>  49
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12
ggguggaaua guauaacaau augcuaaaug uuguuauagu aucccaccu                   49


<210>  13
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
guggaauagu auaacaauau                                                   20


<210>  14
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
auguuguuau aguaucccac                                                   20


<210>  15
<211>  45
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
guggaauagu auaacaauau gcuaaauguu guuauaguau cccac                       45


<210>  16
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16
ggugucgaga auaguauaac aauau                                             25


<210>  17
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
auguuguuau aguauccucg acacc                                             25


<210>  18
<211>  55
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18
ggugucgaga auaguauaac aauaugcuaa auguuguuau aguauccucg acacc            55


<210>  19
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
ggguggaaua guauaacaau au                                                22


<210>  20
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20
auguuguuau aguaucccac cu                                                22


<210>  21
<211>  49
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
ggguggaaua guauaacaau augcuaaaug uuguuauagu aucccaccu                   49


<210>  22
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22
ggguggaaua guauacca                                                     18


<210>  23
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23
ugguauagua ucccaccu                                                     18


<210>  24
<211>  40
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24
ggguggaaua guauaccauu cgugguauag uaucccaccu                             40


<210>  25
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25
guggguggaa uaguauacca                                                   20


<210>  26
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26
ugguauagua ucccaccuac                                                   20


<210>  27
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
guggguggaa uaguauacca uucgugguau aguaucccac cuac                        44


<210>  28
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28
uggguggaau aguauacca                                                    19


<210>  29
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29
ugguauagua ucccaccua                                                    19


<210>  30
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30
uggguggaau aguauaccau ucgugguaua guaucccacc ua                          42


<210>  31
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31
gguggaauag uauacca                                                      17


<210>  32
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32
ugguauagua ucccacc                                                      17


<210>  33
<211>  38
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33
gguggaauag uauaccauuc gugguauagu aucccacc                               38


<210>  34
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34
guggaauagu auacca                                                       16


<210>  35
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35
ugguauagua ucccac                                                       16


<210>  36
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36
guggaauagu auaccauucg ugguauagua ucccac                                 36


<210>  37
<211>  45
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37
ggugaauagu auaacaauau gcuaaauguu guuauaguau ccacc                       45


<210>  38
<211>  45
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38
ggugaagagg agaacaauau gcuaaauguu guucucgucu ccacc                       45


<210>  39
<211>  55
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acacc            55


<210>  40
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains 2'-O-Me and phosphorothioate internucleoside linkages; 
       see specification as filed for detailed description of 
       modifications and preferred embodiments

<400>  40
ggagaagagg agaaaaagaa aggggaa                                           27


<210>  41
<211>  49
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41
ggguggaaua guauaacaau augcuaaaug uuguuauagu aucccaccu                   49


<210>  42
<211>  45
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42
guggaauagu auaacaauau gcuaaauguu guuauaguau cccac                       45


<210>  43
<211>  55
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43
ggugucgaga auaguauaac aauaugcuaa auguuguuau aguauccucg acacc            55


<210>  44
<211>  49
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44
ggguggaaua guauaacaau augcuaaaug uuguuauagu aucccaccu                   49


<210>  45
<211>  40
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45
ggguggaaua guauaccauu cgugguauag uaucccaccu                             40


<210>  46
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46
guggguggaa uaguauacca uucgugguau aguaucccac cuac                        44


<210>  47
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47
uggguggaau aguauaccau ucgugguaua guaucccacc ua                          42


<210>  48
<211>  38
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48
gguggaauag uauaccauuc gugguauagu aucccacc                               38


<210>  49
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49
guggaauagu auaccauucg ugguauagua ucccac                                 36


<210>  50
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50
acatgaggat cacccatgt                                                    19


<210>  51
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51

Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      


<210>  52
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52

Ala Ala Leu Leu Pro Val Leu Leu Ala Ala Pro 
1               5                   10      


<210>  53
<211>  13
<212>  PRT
<213>  HIV

<400>  53

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  54
<211>  16
<212>  PRT
<213>  Drosophila sp.

<400>  54

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  55
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55
agtgtaagaa attcttggat tatgt                                             25


<210>  56
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56
acacagaagg gaactagaca gt                                                22


<210>  57
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57
acagtatcca tttattatgt aatgcttctt ag                                     32


<210>  58
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58
tgaaaggagc gccttctaga ac                                                22


<210>  59
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59
cttaagagcc aaaaagcttt tcatc                                             25


<210>  60
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60
tctctttaca gaagaactca gcc                                               23


<210>  61
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  61
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  62
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  62
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  63
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  63
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  64
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  64
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  65
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  65
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  66
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  66
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  67
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  67
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  68
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  68
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  69
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  69
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  70
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  70
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  71
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  71
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  72
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  72
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  73
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  73
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  74
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  74
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  75
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  75
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  76
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  76
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  77
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  77
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  78
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  78
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  79
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  79
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  80
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  80
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  81
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  81
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  82
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  82
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  83
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  83
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  84
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  84
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  85
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  85
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  86
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  86
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  87
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  87
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  88
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  88
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  89
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  89
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  90
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  90
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  91
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  91
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  92
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  92
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  93
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  93
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  94
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  94
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  95
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  95
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  96
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  96
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  97
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  97
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  98
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  98
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  99
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  99
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  100
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  100
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  101
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  101
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  102
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  102
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuu                     47


<210>  103
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  103
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  104
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  104
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  105
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  105
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  106
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  106
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  107
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  107
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  108
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  108
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  109
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  109
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  110
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  110
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  111
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  111
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  112
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  112
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  113
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  113
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  114
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  114
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  115
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  115
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  116
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  116
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  117
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  117
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  118
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  118
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  119
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  119
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  120
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  120
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  121
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  121
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  122
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  122
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  123
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  123
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  124
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  124
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  125
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  125
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  126
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  126
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  127
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  127
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  128
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  128
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  129
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  129
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  130
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  130
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  131
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  131
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  132
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  132
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  133
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  133
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  134
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  134
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  135
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  135
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  136
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  136
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  137
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  137
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  138
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  138
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  139
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  139
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  140
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  140
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  141
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  141
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  142
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  142
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  143
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  143
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  144
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  144
uucuuguguc uacuguacag aauacugccg ccagcuggau uu                          42


<210>  145
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  145
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  146
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  146
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  147
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  147
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  148
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  148
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  149
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  149
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  150
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  150
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  151
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  151
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  152
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  152
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  153
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  153
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  154
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  154
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  155
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  155
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  156
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  156
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  157
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  157
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  158
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  158
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  159
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  159
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  160
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  160
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  161
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  161
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  162
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  162
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  163
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  163
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  164
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  164
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  165
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  165
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  166
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  166
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  167
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  167
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  168
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  168
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  169
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  169
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  170
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  170
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  171
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  171
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  172
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  172
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  173
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  173
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  174
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  174
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  175
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  175
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  176
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  176
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  177
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  177
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  178
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  178
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  179
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  179
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  180
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  180
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  181
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  181
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  182
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  182
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  183
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  183
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  184
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  184
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  185
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  185
gugucuacug uacagaauac ugccgccagc uggauuu                                37


<210>  186
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  contains RNA/DNA nucleotides, 2'-O-Me and phosphorothioate 
       internucleoside linkages; see specification as filed for detailed
       description of modifications and preferred embodiments

<400>  186
gugucuacug uacagaauac ugccgccagc uggauuu                                37


