                         SEQUENCE LISTING

<110>  Yale University
       Eichmann, Anne
       Boye, Kevin
       Pibouin-Fragner, Laurence
       Geraldo, Luiz
 
<120>  Unc5B Function Blocking Antibodies

<130>  047162-7281WO1(01732)

<150>  63/215,471
<151>  2021-06-27

<160>  84    

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1

<400>  1

Ser Val Ser Ser Ala Val Ala 
1               5           


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2

<400>  2

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  3
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  3

Gln His Tyr Ser Leu Phe 
1               5       


<210>  4
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  4

Gln Gly Phe Ala Pro Phe 
1               5       


<210>  5
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  5

Gln Ser Tyr Gly Pro Phe 
1               5       


<210>  6
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  6

Gln Ser Tyr Ser Pro Phe 
1               5       


<210>  7
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  7

Gln His Tyr Ala Leu Phe 
1               5       


<210>  8
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  8

Gln His Tyr Gly Leu Ile 
1               5       


<210>  9
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  9

Gln Ala Gly Trp Pro Ile 
1               5       


<210>  10
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  10

Gln Ala Tyr Ser Pro Phe 
1               5       


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  11

Gln His Tyr Ser Tyr Pro Ile 
1               5           


<210>  12
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  12

Gln Ala Tyr Ala Leu Ile 
1               5       


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1

<400>  13

Phe Asn Ile Ser Tyr Ser Ser Ile His Trp 
1               5                   10  


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1

<400>  14

Phe Asn Leu Tyr Tyr Ser Ser Ile His Trp 
1               5                   10  


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1

<400>  15

Phe Asn Leu Tyr Tyr Tyr Ser Met His Trp 
1               5                   10  


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1

<400>  16

Phe Asn Ile Tyr Tyr Ser Tyr Met His Trp 
1               5                   10  


<210>  17
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1

<400>  17

Phe Asn Leu Tyr Tyr Tyr Ser Ile His Trp 
1               5                   10  


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1

<400>  18

Phe Asn Ile Tyr Tyr Ser Ser Met His Trp 
1               5                   10  


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1

<400>  19

Phe Asn Ile Ser Ser Tyr Tyr Ser Ile His Trp 
1               5                   10      


<210>  20
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  20

Ala Tyr Ile Tyr Pro Tyr Tyr Gly Tyr Thr Tyr 
1               5                   10      


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  21

Ala Ser Ile Tyr Ser Tyr Ser Ser Tyr Thr Ser 
1               5                   10      


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  22

Ala Ser Ile Tyr Pro Tyr Ser Ser Tyr Thr Ser 
1               5                   10      


<210>  23
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  23

Ala Ser Ile Tyr Ser Ser Ser Gly Tyr Thr Ser 
1               5                   10      


<210>  24
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  24

Ala Ser Ile Tyr Ser Ser Ser Ser Ser Thr Tyr 
1               5                   10      


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3

<400>  25

Arg Gly Tyr Gly Ile Asp Tyr 
1               5           


<210>  26
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3

<400>  26

Arg Ser Tyr Ala Met Asp Tyr 
1               5           


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3

<400>  27

Arg His Tyr Ala Met Asp Tyr 
1               5           


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3

<400>  28

Arg Gly Tyr Ala Phe Asn Tyr 
1               5           


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3

<400>  29

Arg Gly Tyr Ala Met Asp Tyr 
1               5           


<210>  30
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3

<400>  30

Arg Gly Tyr Tyr Ala Gly Tyr Phe Gly Ile Asp Tyr 
1               5                   10          


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3

<400>  31

Arg Ser Phe Ala Met Asp Tyr 
1               5           


<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3

<400>  32

Arg Gly Tyr Gly Leu Asp Tyr 
1               5           


<210>  33
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain- 1095

<400>  33

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His 
            100                 105                 110         


Tyr Ser Leu Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  34
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain- 1096

<400>  34

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly 
            100                 105                 110         


Phe Ala Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  35
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain- 1097

<400>  35

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser 
            100                 105                 110         


Tyr Gly Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  36
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain- 1098

<400>  36

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser 
            100                 105                 110         


Tyr Ser Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  37
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain- 1099

<400>  37

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His 
            100                 105                 110         


Tyr Ala Leu Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  38
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain- 1100

<400>  38

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His 
            100                 105                 110         


Tyr Gly Leu Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  39
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain- 1101

<400>  39

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala 
            100                 105                 110         


Gly Trp Pro Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  40
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain- 1102

<400>  40

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala 
            100                 105                 110         


Tyr Ser Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  41
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain- 1103

<400>  41

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His 
            100                 105                 110         


Tyr Ser Tyr Pro Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  42
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain- 1104

<400>  42

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala 
            100                 105                 110         


Tyr Ala Leu Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  43
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain- 1095

<400>  43

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Glu Ile Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Asn Ile Ser Tyr Ser Ser Ile His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Tyr Ile Tyr Pro Tyr Tyr Gly Tyr Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr 
                85                  90                  95      


Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Gly Ile Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
225                 230                 235                 240 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


<210>  44
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain- 1096

<400>  44

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Glu Ile Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Asn Leu Tyr Tyr Ser Ser Ile His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Ser Ile Tyr Ser Tyr Ser Ser Tyr Thr 
65                  70                  75                  80  


Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr 
                85                  90                  95      


Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Tyr Ala Met Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
225                 230                 235                 240 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  45
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain- 1097

<400>  45

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Glu Ile Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Asn Leu Tyr Tyr Tyr Ser Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Ser Ile Tyr Ser Tyr Ser Ser Tyr Thr 
65                  70                  75                  80  


Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr 
                85                  90                  95      


Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Tyr Ala Met Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
225                 230                 235                 240 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  46
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain- 1098

<400>  46

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Glu Ile Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Asn Ile Tyr Tyr Ser Tyr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Ser Ile Tyr Ser Tyr Ser Ser Tyr Thr 
65                  70                  75                  80  


Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr 
                85                  90                  95      


Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg His Tyr Ala Met Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
225                 230                 235                 240 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  47
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain- 1099

<400>  47

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Glu Ile Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Asn Leu Tyr Tyr Tyr Ser Ile His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Ser Ile Tyr Pro Tyr Ser Ser Tyr Thr 
65                  70                  75                  80  


Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr 
                85                  90                  95      


Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Ala Phe Asn Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
225                 230                 235                 240 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  48
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain- 1100

<400>  48

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Glu Ile Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Asn Leu Tyr Tyr Ser Ser Ile His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Ser Ile Tyr Ser Tyr Ser Ser Tyr Thr 
65                  70                  75                  80  


Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr 
                85                  90                  95      


Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Ala Met Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
225                 230                 235                 240 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  49
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain- 1101

<400>  49

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Glu Ile Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Asn Ile Tyr Tyr Ser Ser Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Tyr Ile Ser Ser Ser Tyr Gly Tyr Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr 
                85                  90                  95      


Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Tyr Ala Gly Tyr Phe Gly 
        115                 120                 125             


Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
145                 150                 155                 160 


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr 
    210                 215                 220                 


Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val 
225                 230                 235                 240 


Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
                245                 250                 255     


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
305                 310                 315                 320 


Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ser Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  50
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain- 1102

<400>  50

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Glu Ile Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Asn Ile Tyr Tyr Ser Ser Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Ser Ile Tyr Ser Tyr Ser Ser Tyr Thr 
65                  70                  75                  80  


Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr 
                85                  90                  95      


Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Phe Ala Met Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
225                 230                 235                 240 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  51
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain- 1103

<400>  51

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Glu Ile Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Asn Ile Ser Tyr Tyr Ser Ile His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Ser Ile Tyr Ser Ser Ser Gly Tyr Thr 
65                  70                  75                  80  


Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr 
                85                  90                  95      


Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Gly Leu Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
225                 230                 235                 240 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  52
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain- 1104

<400>  52

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Glu Ile Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Asn Ile Ser Tyr Tyr Ser Ile His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Ser Ile Tyr Ser Ser Ser Ser Ser Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr 
                85                  90                  95      


Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Gly Leu Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
225                 230                 235                 240 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  53
<211>  1400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain- 1095

<400>  53
atgaagcacc tgtggttctt tctgctgctg gtggccgctc caagatgggt gctgagcgag       60

atctctgagg tgcagctggt ggagagcgga ggaggactgg tgcagccagg aggatccctg      120

agactgagct gcgccgcttc tggcttcaac atctcttact ccagcatcca ttgggtgcgc      180

caggctccag gcaagggact ggagtgggtg gcttacatct atccttacta tggctacacc      240

tactatgccg actctgtgaa gggcaggttc accatctccg ccgataccag caagaacaca      300

gcttatctgc agatgaactc cctgagggcc gaggacaccg ccgtgtacta ttgtgctcgg      360

ggctacggca tcgattattg gggccagggc accctggtga cagtgtcttc cgctagcacc      420

aagggcccct ccgtgttccc tctggccccc tgtagcagaa gcacaagcga gtccaccgcc      480

gccctgggct gtctggtgaa ggactacttt cctgagcctg tgaccgtgtc ctggaatagc      540

ggcgccctga cctccggcgt gcacacattt cctgccgtgc tgcagtcctc cggcctgtac      600

agcctgagca gcgtggtgac agtgcccagc tccaacttcg gcacacagac atacacctgc      660

aatgtggatc acaagccttc caacacaaag gtggacaaga ccgtggagag aaagtgttgc      720

gtggagtgcc ctccttgccc cgcccctcca gtggctggac catccgtgtt cctgtttccc      780

cctaagccca aggatacact gatgatcagc aggacccccg aggtgacatg cgtggtggtg      840

gatgtgagcc acgaggaccc cgaggtgcag tttaactggt acgtggacgg cgtggaggtg      900

cacaacgcca agacaaagcc cagggaggag cagttcaatt ccaccttcag agtggtgagc      960

gtgctgaccg tggtgcacca ggattggctg aatggcaagg agtacaagtg taaggtgtcc     1020

aacaagggcc tgcccgcccc catcgagaag accatctcca agacaaaggg ccagcccagg     1080

gagccccagg tgtacacact gccccctagc agggaggaga tgacaaagaa ccaggtgtcc     1140

ctgacctgcc tggtgaaggg cttctaccct agcgacatca gcgtggagtg ggagtccaat     1200

ggccagcccg agaataacta caagaccacc ccccctatgc tggatagcga cggcagcttt     1260

ttcctgtact ccaagctgac agtggacaag tccaggtggc agcagggcaa cgtgtttagc     1320

tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagagcct gtccctgtcc     1380

cccggcaagt gagcggccgc                                                 1400


<210>  54
<211>  1400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain- 1096

<400>  54
atgaagcacc tgtggttctt tctgctgctg gtggctgctc caagatgggt gctgtccgag       60

atcagcgagg tgcagctggt ggagagcgga ggaggactgg tgcagcctgg aggcagcctg      120

agactgtctt gcgccgcttc cggcttcaac ctgtactatt ccagcatcca ttgggtgcgc      180

caggctccag gcaagggact ggagtgggtg gcttctatct actcctattc ttcctacacc      240

agctatgccg actctgtgaa gggcaggttc accatctccg ccgataccag caagaacaca      300

gcttacctgc agatgaactc cctgagggcc gaggacaccg ccgtgtacta ttgtgcccgg      360

tcctacgcta tggattattg gggccagggc accctggtga cagtgagctc tgctagcacc      420

aagggcccct ccgtgttccc tctggccccc tgtagcagaa gcacaagcga gtccaccgcc      480

gccctgggct gtctggtgaa ggactacttt cctgagcctg tgaccgtgtc ctggaatagc      540

ggcgccctga cctccggcgt gcacacattt cctgccgtgc tgcagtcctc cggcctgtac      600

agcctgagca gcgtggtgac agtgcccagc tccaacttcg gcacacagac atacacctgc      660

aatgtggatc acaagccttc caacacaaag gtggacaaga ccgtggagag aaagtgttgc      720

gtggagtgcc ctccttgccc cgcccctcca gtggctggac catccgtgtt cctgtttccc      780

cctaagccca aggatacact gatgatcagc aggacccccg aggtgacatg cgtggtggtg      840

gatgtgagcc acgaggaccc cgaggtgcag tttaactggt acgtggacgg cgtggaggtg      900

cacaacgcca agacaaagcc cagggaggag cagttcaatt ccaccttcag agtggtgagc      960

gtgctgaccg tggtgcacca ggattggctg aatggcaagg agtacaagtg taaggtgtcc     1020

aacaagggcc tgcccgcccc catcgagaag accatctcca agacaaaggg ccagcccagg     1080

gagccccagg tgtacacact gccccctagc agggaggaga tgacaaagaa ccaggtgtcc     1140

ctgacctgcc tggtgaaggg cttctaccct agcgacatca gcgtggagtg ggagtccaat     1200

ggccagcccg agaataacta caagaccacc ccccctatgc tggatagcga cggcagcttt     1260

ttcctgtact ccaagctgac agtggacaag tccaggtggc agcagggcaa cgtgtttagc     1320

tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagagcct gtccctgtcc     1380

cccggcaagt gagcggccgc                                                 1400


<210>  55
<211>  1400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain- 1097

<400>  55
atgaagcacc tgtggttctt tctgctgctg gtggctgctc caagatgggt gctgagcgag       60

atctctgagg tgcagctggt ggagtctgga ggaggactgg tgcagcctgg aggatctctg      120

agactgtcct gcgctgcctc cggcttcaac ctgtactatt actccatgca ttgggtgcgc      180

caggctccag gcaagggact ggagtgggtg gcttccatct atagctactc cagctatacc      240

tcttacgccg actccgtgaa gggcaggttc accatcagcg ccgatacctc taagaacaca      300

gcttatctgc agatgaactc cctgagggcc gaggacaccg ccgtgtacta ctgtgcccgg      360

agctatgcta tggattactg gggccagggc accctggtga cagtgtcttc cgctagcacc      420

aagggcccct ccgtgttccc tctggccccc tgtagcagaa gcacaagcga gtccaccgcc      480

gccctgggct gtctggtgaa ggactacttt cctgagcctg tgaccgtgtc ctggaatagc      540

ggcgccctga cctccggcgt gcacacattt cctgccgtgc tgcagtcctc cggcctgtac      600

agcctgagca gcgtggtgac agtgcccagc tccaacttcg gcacacagac atacacctgc      660

aatgtggatc acaagccttc caacacaaag gtggacaaga ccgtggagag aaagtgttgc      720

gtggagtgcc ctccttgccc cgcccctcca gtggctggac catccgtgtt cctgtttccc      780

cctaagccca aggatacact gatgatcagc aggacccccg aggtgacatg cgtggtggtg      840

gatgtgagcc acgaggaccc cgaggtgcag tttaactggt acgtggacgg cgtggaggtg      900

cacaacgcca agacaaagcc cagggaggag cagttcaatt ccaccttcag agtggtgagc      960

gtgctgaccg tggtgcacca ggattggctg aatggcaagg agtacaagtg taaggtgtcc     1020

aacaagggcc tgcccgcccc catcgagaag accatctcca agacaaaggg ccagcccagg     1080

gagccccagg tgtacacact gccccctagc agggaggaga tgacaaagaa ccaggtgtcc     1140

ctgacctgcc tggtgaaggg cttctaccct agcgacatca gcgtggagtg ggagtccaat     1200

ggccagcccg agaataacta caagaccacc ccccctatgc tggatagcga cggcagcttt     1260

ttcctgtact ccaagctgac agtggacaag tccaggtggc agcagggcaa cgtgtttagc     1320

tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagagcct gtccctgtcc     1380

cccggcaagt gagcggccgc                                                 1400


<210>  56
<211>  1400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain- 1098

<400>  56
atgaagcacc tgtggttctt tctgctgctg gtggctgctc caagatgggt gctgagcgag       60

atctctgagg tgcagctggt ggagtccgga ggaggactgg tgcagcctgg aggatctctg      120

agactgtcct gcgctgcctc cggcttcaac atctactata gctacatgca ttgggtgcgc      180

caggctccag gcaagggact ggagtgggtg gcttccatct acagctattc cagctacacc      240

tcttatgccg actccgtgaa gggcaggttc accatcagcg ccgatacctc taagaacaca      300

gcttatctgc agatgaactc cctgagggcc gaggacaccg ccgtgtacta ttgtgcccgg      360

cactacgcta tggattattg gggccagggc accctggtga cagtgtcttc cgctagcacc      420

aagggcccct ccgtgttccc tctggccccc tgtagcagaa gcacaagcga gtccaccgcc      480

gccctgggct gtctggtgaa ggactacttt cctgagcctg tgaccgtgtc ctggaatagc      540

ggcgccctga cctccggcgt gcacacattt cctgccgtgc tgcagtcctc cggcctgtac      600

agcctgagca gcgtggtgac agtgcccagc tccaacttcg gcacacagac atacacctgc      660

aatgtggatc acaagccttc caacacaaag gtggacaaga ccgtggagag aaagtgttgc      720

gtggagtgcc ctccttgccc cgcccctcca gtggctggac catccgtgtt cctgtttccc      780

cctaagccca aggatacact gatgatcagc aggacccccg aggtgacatg cgtggtggtg      840

gatgtgagcc acgaggaccc cgaggtgcag tttaactggt acgtggacgg cgtggaggtg      900

cacaacgcca agacaaagcc cagggaggag cagttcaatt ccaccttcag agtggtgagc      960

gtgctgaccg tggtgcacca ggattggctg aatggcaagg agtacaagtg taaggtgtcc     1020

aacaagggcc tgcccgcccc catcgagaag accatctcca agacaaaggg ccagcccagg     1080

gagccccagg tgtacacact gccccctagc agggaggaga tgacaaagaa ccaggtgtcc     1140

ctgacctgcc tggtgaaggg cttctaccct agcgacatca gcgtggagtg ggagtccaat     1200

ggccagcccg agaataacta caagaccacc ccccctatgc tggatagcga cggcagcttt     1260

ttcctgtact ccaagctgac agtggacaag tccaggtggc agcagggcaa cgtgtttagc     1320

tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagagcct gtccctgtcc     1380

cccggcaagt gagcggccgc                                                 1400


<210>  57
<211>  1400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain- 1099

<400>  57
atgaagcacc tgtggttctt tctgctgctg gtggccgctc caagatgggt gctgagcgag       60

atctctgagg tgcagctggt ggagtccgga ggaggactgg tgcagccagg aggatccctg      120

agactgagct gcgccgcttc tggcttcaac ctgtactatt acagcatcca ttgggtgcgc      180

caggctccag gcaagggact ggagtgggtg gcttctatct atccttactc cagctatacc      240

tcctacgccg acagcgtgaa gggcagattc acaatctctg ccgatacctc caagaacaca      300

gcttatctgc agatgaactc cctgagggcc gaggacaccg ccgtgtacta ctgtgcccgg      360

ggctatgctt ttaattactg gggccagggc accctggtga cagtgtcttc cgctagcacc      420

aagggcccct ccgtgttccc tctggccccc tgtagcagaa gcacaagcga gtccaccgcc      480

gccctgggct gtctggtgaa ggactacttt cctgagcctg tgaccgtgtc ctggaatagc      540

ggcgccctga cctccggcgt gcacacattt cctgccgtgc tgcagtcctc cggcctgtac      600

agcctgagca gcgtggtgac agtgcccagc tccaacttcg gcacacagac atacacctgc      660

aatgtggatc acaagccttc caacacaaag gtggacaaga ccgtggagag aaagtgttgc      720

gtggagtgcc ctccttgccc cgcccctcca gtggctggac catccgtgtt cctgtttccc      780

cctaagccca aggatacact gatgatcagc aggacccccg aggtgacatg cgtggtggtg      840

gatgtgagcc acgaggaccc cgaggtgcag tttaactggt acgtggacgg cgtggaggtg      900

cacaacgcca agacaaagcc cagggaggag cagttcaatt ccaccttcag agtggtgagc      960

gtgctgaccg tggtgcacca ggattggctg aatggcaagg agtacaagtg taaggtgtcc     1020

aacaagggcc tgcccgcccc catcgagaag accatctcca agacaaaggg ccagcccagg     1080

gagccccagg tgtacacact gccccctagc agggaggaga tgacaaagaa ccaggtgtcc     1140

ctgacctgcc tggtgaaggg cttctaccct agcgacatca gcgtggagtg ggagtccaat     1200

ggccagcccg agaataacta caagaccacc ccccctatgc tggatagcga cggcagcttt     1260

ttcctgtact ccaagctgac agtggacaag tccaggtggc agcagggcaa cgtgtttagc     1320

tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagagcct gtccctgtcc     1380

cccggcaagt gagcggccgc                                                 1400


<210>  58
<211>  1400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain- 1100

<400>  58
atgaagcacc tgtggttctt tctgctgctg gtggctgctc caagatgggt gctgtccgag       60

atcagcgagg tgcagctggt ggagtctgga ggaggactgg tgcagcctgg aggaagcctg      120

agactgtctt gcgccgcttc cggcttcaac ctgtactatt ccagcatcca ttgggtgcgc      180

caggctccag gcaagggact ggagtgggtg gcttctatct actcctattc ttcctacacc      240

agctatgccg actctgtgaa gggcaggttc accatctccg ccgataccag caagaacaca      300

gcttacctgc agatgaactc cctgagggcc gaggacaccg ccgtgtacta ttgtgcccgg      360

ggctacgcta tggattattg gggccagggc accctggtga cagtgagctc tgctagcacc      420

aagggcccct ccgtgttccc tctggccccc tgtagcagaa gcacaagcga gtccaccgcc      480

gccctgggct gtctggtgaa ggactacttt cctgagcctg tgaccgtgtc ctggaatagc      540

ggcgccctga cctccggcgt gcacacattt cctgccgtgc tgcagtcctc cggcctgtac      600

agcctgagca gcgtggtgac agtgcccagc tccaacttcg gcacacagac atacacctgc      660

aatgtggatc acaagccttc caacacaaag gtggacaaga ccgtggagag aaagtgttgc      720

gtggagtgcc ctccttgccc cgcccctcca gtggctggac catccgtgtt cctgtttccc      780

cctaagccca aggatacact gatgatcagc aggacccccg aggtgacatg cgtggtggtg      840

gatgtgagcc acgaggaccc cgaggtgcag tttaactggt acgtggacgg cgtggaggtg      900

cacaacgcca agacaaagcc cagggaggag cagttcaatt ccaccttcag agtggtgagc      960

gtgctgaccg tggtgcacca ggattggctg aatggcaagg agtacaagtg taaggtgtcc     1020

aacaagggcc tgcccgcccc catcgagaag accatctcca agacaaaggg ccagcccagg     1080

gagccccagg tgtacacact gccccctagc agggaggaga tgacaaagaa ccaggtgtcc     1140

ctgacctgcc tggtgaaggg cttctaccct agcgacatca gcgtggagtg ggagtccaat     1200

ggccagcccg agaataacta caagaccacc ccccctatgc tggatagcga cggcagcttt     1260

ttcctgtact ccaagctgac agtggacaag tccaggtggc agcagggcaa cgtgtttagc     1320

tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagagcct gtccctgtcc     1380

cccggcaagt gagcggccgc                                                 1400


<210>  59
<211>  1415
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain- 1101

<400>  59
atgaagcacc tgtggttctt tctgctgctg gtggctgctc caagatgggt gctgagcgag       60

atctctgagg tgcagctggt ggagtccgga ggaggactgg tgcagcctgg aggatccctg      120

agactgagct gcgccgcttc tggcttcaac atctactatt ccagcatgca ttgggtgcgc      180

caggctccag gcaagggact ggagtgggtg gcttacatct cttccagcta cggctatacc      240

tactatgccg actctgtgaa gggcagattc acaatctccg ccgataccag caagaacaca      300

gcttatctgc agatgaactc cctgagggcc gaggacaccg ccgtgtacta ttgtgcccgg      360

ggctactatg ctggctactt tggcatcgat tattggggcc agggcaccct ggtgacagtg      420

tcttccgcta gcaccaaggg cccctccgtg ttccctctgg ccccctgtag cagaagcaca      480

agcgagtcca ccgccgccct gggctgtctg gtgaaggact actttcctga gcctgtgacc      540

gtgtcctgga atagcggcgc cctgacctcc ggcgtgcaca catttcctgc cgtgctgcag      600

tcctccggcc tgtacagcct gagcagcgtg gtgacagtgc ccagctccaa cttcggcaca      660

cagacataca cctgcaatgt ggatcacaag ccttccaaca caaaggtgga caagaccgtg      720

gagagaaagt gttgcgtgga gtgccctcct tgccccgccc ctccagtggc tggaccatcc      780

gtgttcctgt ttccccctaa gcccaaggat acactgatga tcagcaggac ccccgaggtg      840

acatgcgtgg tggtggatgt gagccacgag gaccccgagg tgcagtttaa ctggtacgtg      900

gacggcgtgg aggtgcacaa cgccaagaca aagcccaggg aggagcagtt caattccacc      960

ttcagagtgg tgagcgtgct gaccgtggtg caccaggatt ggctgaatgg caaggagtac     1020

aagtgtaagg tgtccaacaa gggcctgccc gcccccatcg agaagaccat ctccaagaca     1080

aagggccagc ccagggagcc ccaggtgtac acactgcccc ctagcaggga ggagatgaca     1140

aagaaccagg tgtccctgac ctgcctggtg aagggcttct accctagcga catcagcgtg     1200

gagtgggagt ccaatggcca gcccgagaat aactacaaga ccaccccccc tatgctggat     1260

agcgacggca gctttttcct gtactccaag ctgacagtgg acaagtccag gtggcagcag     1320

ggcaacgtgt ttagctgcag cgtgatgcac gaggccctgc acaaccacta cacccagaag     1380

agcctgtccc tgtcccccgg caagtgagcg gccgc                                1415


<210>  60
<211>  1400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain- 1102

<400>  60
atgaagcacc tgtggttctt tctgctgctg gtggctgctc caagatgggt gctgtccgag       60

atcagcgagg tgcagctggt ggagagcgga ggaggactgg tgcagcctgg aggcagcctg      120

agactgtctt gcgccgcttc cggcttcaac atctactatt ccagcatgca ttgggtgcgc      180

caggctccag gcaagggact ggagtgggtg gcttctatct actcctattc ttcctacacc      240

agctatgccg actctgtgaa gggcagattc acaatctccg ccgataccag caagaacaca      300

gcttacctgc agatgaactc cctgagggcc gaggacaccg ccgtgtacta ttgtgcccgg      360

tcctttgcta tggattattg gggccagggc accctggtga cagtgagctc tgctagcacc      420

aagggcccct ccgtgttccc tctggccccc tgtagcagaa gcacaagcga gtccaccgcc      480

gccctgggct gtctggtgaa ggactacttt cctgagcctg tgaccgtgtc ctggaatagc      540

ggcgccctga cctccggcgt gcacacattt cctgccgtgc tgcagtcctc cggcctgtac      600

agcctgagca gcgtggtgac agtgcccagc tccaacttcg gcacacagac atacacctgc      660

aatgtggatc acaagccttc caacacaaag gtggacaaga ccgtggagag aaagtgttgc      720

gtggagtgcc ctccttgccc cgcccctcca gtggctggac catccgtgtt cctgtttccc      780

cctaagccca aggatacact gatgatcagc aggacccccg aggtgacatg cgtggtggtg      840

gatgtgagcc acgaggaccc cgaggtgcag tttaactggt acgtggacgg cgtggaggtg      900

cacaacgcca agacaaagcc cagggaggag cagttcaatt ccaccttcag agtggtgagc      960

gtgctgaccg tggtgcacca ggattggctg aatggcaagg agtacaagtg taaggtgtcc     1020

aacaagggcc tgcccgcccc catcgagaag accatctcca agacaaaggg ccagcccagg     1080

gagccccagg tgtacacact gccccctagc agggaggaga tgacaaagaa ccaggtgtcc     1140

ctgacctgcc tggtgaaggg cttctaccct agcgacatca gcgtggagtg ggagtccaat     1200

ggccagcccg agaataacta caagaccacc ccccctatgc tggatagcga cggcagcttt     1260

ttcctgtact ccaagctgac agtggacaag tccaggtggc agcagggcaa cgtgtttagc     1320

tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagagcct gtccctgtcc     1380

cccggcaagt gagcggccgc                                                 1400


<210>  61
<211>  1400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain- 1103

<400>  61
atgaagcacc tgtggttctt tctgctgctg gtggctgctc caagatgggt gctgtctgag       60

atctccgagg tgcagctggt ggagtccgga ggaggactgg tgcagcctgg aggatccctg      120

agactgagct gcgccgcttc tggcttcaac atcagctact attctatcca ttgggtgcgc      180

caggctccag gcaagggact ggagtgggtg gcctccatct actccagctc tggctacacc      240

tcctatgccg acagcgtgaa gggcaggttc accatctctg ccgatacctc caagaacaca      300

gcttatctgc agatgaactc cctgagggcc gaggacaccg ccgtgtacta ttgtgctcgg      360

ggctacggcc tggattattg gggccagggc accctggtga cagtgtccag cgctagcacc      420

aagggcccct ccgtgttccc tctggccccc tgtagcagaa gcacaagcga gtccaccgcc      480

gccctgggct gtctggtgaa ggactacttt cctgagcctg tgaccgtgtc ctggaatagc      540

ggcgccctga cctccggcgt gcacacattt cctgccgtgc tgcagtcctc cggcctgtac      600

agcctgagca gcgtggtgac agtgcccagc tccaacttcg gcacacagac atacacctgc      660

aatgtggatc acaagccttc caacacaaag gtggacaaga ccgtggagag aaagtgttgc      720

gtggagtgcc ctccttgccc cgcccctcca gtggctggac catccgtgtt cctgtttccc      780

cctaagccca aggatacact gatgatcagc aggacccccg aggtgacatg cgtggtggtg      840

gatgtgagcc acgaggaccc cgaggtgcag tttaactggt acgtggacgg cgtggaggtg      900

cacaacgcca agacaaagcc cagggaggag cagttcaatt ccaccttcag agtggtgagc      960

gtgctgaccg tggtgcacca ggattggctg aatggcaagg agtacaagtg taaggtgtcc     1020

aacaagggcc tgcccgcccc catcgagaag accatctcca agacaaaggg ccagcccagg     1080

gagccccagg tgtacacact gccccctagc agggaggaga tgacaaagaa ccaggtgtcc     1140

ctgacctgcc tggtgaaggg cttctaccct agcgacatca gcgtggagtg ggagtccaat     1200

ggccagcccg agaataacta caagaccacc ccccctatgc tggatagcga cggcagcttt     1260

ttcctgtact ccaagctgac agtggacaag tccaggtggc agcagggcaa cgtgtttagc     1320

tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagagcct gtccctgtcc     1380

cccggcaagt gagcggccgc                                                 1400


<210>  62
<211>  1400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain- 1104

<400>  62
atgaagcacc tgtggttctt tctgctgctg gtggctgctc caagatgggt gctgagcgag       60

atctctgagg tgcagctggt ggagtccgga ggaggactgg tgcagcctgg aggatctctg      120

agactgtcct gcgctgcctc cggcttcaac atctcctact atagcatcca ttgggtgcgc      180

caggctccag gcaagggact ggagtgggtg gcctccatct actccagctc ttccagcacc      240

tactatgccg actctgtgaa gggcaggttc accatctctg ccgatacctc caagaacaca      300

gcttatctgc agatgaatag cctgagggcc gaggacaccg ccgtgtacta ttgtgctcgg      360

ggctacggcc tggattattg gggccagggc accctggtga cagtgtcttc cgctagcacc      420

aagggcccct ccgtgttccc tctggccccc tgtagcagaa gcacaagcga gtccaccgcc      480

gccctgggct gtctggtgaa ggactacttt cctgagcctg tgaccgtgtc ctggaatagc      540

ggcgccctga cctccggcgt gcacacattt cctgccgtgc tgcagtcctc cggcctgtac      600

agcctgagca gcgtggtgac agtgcccagc tccaacttcg gcacacagac atacacctgc      660

aatgtggatc acaagccttc caacacaaag gtggacaaga ccgtggagag aaagtgttgc      720

gtggagtgcc ctccttgccc cgcccctcca gtggctggac catccgtgtt cctgtttccc      780

cctaagccca aggatacact gatgatcagc aggacccccg aggtgacatg cgtggtggtg      840

gatgtgagcc acgaggaccc cgaggtgcag tttaactggt acgtggacgg cgtggaggtg      900

cacaacgcca agacaaagcc cagggaggag cagttcaatt ccaccttcag agtggtgagc      960

gtgctgaccg tggtgcacca ggattggctg aatggcaagg agtacaagtg taaggtgtcc     1020

aacaagggcc tgcccgcccc catcgagaag accatctcca agacaaaggg ccagcccagg     1080

gagccccagg tgtacacact gccccctagc agggaggaga tgacaaagaa ccaggtgtcc     1140

ctgacctgcc tggtgaaggg cttctaccct agcgacatca gcgtggagtg ggagtccaat     1200

ggccagcccg agaataacta caagaccacc ccccctatgc tggatagcga cggcagcttt     1260

ttcctgtact ccaagctgac agtggacaag tccaggtggc agcagggcaa cgtgtttagc     1320

tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagagcct gtccctgtcc     1380

cccggcaagt gagcggccgc                                                 1400


<210>  63
<211>  713
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain- 1095

<400>  63
atggtgctgc agacccaggt gttcatcagc ctgctgctgt ggatctctgg cgcctacggc       60

tccgacatcc agatgacaca gtctccatcc agcctgtctg cctccgtggg cgatagagtg      120

accatcacat gcagggctag ccagtccgtg tcctccgccg tggcttggta tcagcagaag      180

cccggcaagg cccctaagct gctgatctac tccgctagct ctctgtattc cggagtgcca      240

agcaggttct ccggaagccg gtctggaacc gactttaccc tgacaatctc cagcctgcag      300

cccgaggatt ttgctacata ctattgtcag cagcactact ccctgttcac ctttggccag      360

ggcacaaagg tggagatcaa gcgtacggtg gctgcacctt ctgtgttcat cttccctcca      420

tctgatgagc agctgaagtc tggaaccgca tctgtcgtct gtctgctgaa caacttttac      480

cccagggagg ctaaggtcca atggaaggtg gacaacgccc tgcagtctgg taatagccag      540

gaaagcgtga ccgaacagga ttccaaggac tccacctact ccctgtcctc cacactgaca      600

ctgagcaaag ccgactatga aaagcacaaa gtgtatgcct gcgaggtcac tcatcagggc      660

ctgtccagcc ccgtgactaa aagctttaat aggggggagt gctgagcggc cgc             713


<210>  64
<211>  713
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain- 1096

<400>  64
atggtgctgc agacccaggt gttcatcagc ctgctgctgt ggatctctgg cgcctacggc       60

tccgacatcc agatgacaca gtctccttcc agcctgtctg cctccgtggg cgatagagtg      120

accatcacat gcagggctag ccagtccgtg tcctccgccg tggcttggta tcagcagaag      180

cccggcaagg cccctaagct gctgatctac tccgctagct ctctgtattc cggagtgcca      240

agcaggttct ccggaagccg gtctggaacc gactttaccc tgacaatctc cagcctgcag      300

ccagaggatt tcgccacata ctattgtcag cagggctttg ctcccttcac ctttggccag      360

ggcacaaagg tggagatcaa gcgtacggtg gctgcacctt ctgtgttcat cttccctcca      420

tctgatgagc agctgaagtc tggaaccgca tctgtcgtct gtctgctgaa caacttttac      480

cccagggagg ctaaggtcca atggaaggtg gacaacgccc tgcagtctgg taatagccag      540

gaaagcgtga ccgaacagga ttccaaggac tccacctact ccctgtcctc cacactgaca      600

ctgagcaaag ccgactatga aaagcacaaa gtgtatgcct gcgaggtcac tcatcagggc      660

ctgtccagcc ccgtgactaa aagctttaat aggggggagt gctgagcggc cgc             713


<210>  65
<211>  713
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain- 1097

<400>  65
atggtgctgc agacccaggt gttcatcagc ctgctgctgt ggatctctgg cgcctacggc       60

tccgacatcc agatgacaca gtctccttcc agcctgtctg cctccgtggg cgatagagtg      120

accatcacat gcagggctag ccagtccgtg tcctccgccg tggcttggta tcagcagaag      180

cccggcaagg cccctaagct gctgatctac tccgctagct ctctgtattc cggagtgcca      240

agcaggttct ccggaagccg gtctggaacc gactttaccc tgacaatctc cagcctgcag      300

ccagaggatt ttgctacata ctattgtcag cagtcctacg gccccttcac ctttggccag      360

ggcacaaagg tggagatcaa gcgtacggtg gctgcacctt ctgtgttcat cttccctcca      420

tctgatgagc agctgaagtc tggaaccgca tctgtcgtct gtctgctgaa caacttttac      480

cccagggagg ctaaggtcca atggaaggtg gacaacgccc tgcagtctgg taatagccag      540

gaaagcgtga ccgaacagga ttccaaggac tccacctact ccctgtcctc cacactgaca      600

ctgagcaaag ccgactatga aaagcacaaa gtgtatgcct gcgaggtcac tcatcagggc      660

ctgtccagcc ccgtgactaa aagctttaat aggggggagt gctgagcggc cgc             713


<210>  66
<211>  713
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain- 1098

<400>  66
atggtgctgc agacccaggt gttcatctcc ctgctgctgt ggatcagcgg cgcctacggc       60

tctgacatcc agatgacaca gagcccttcc agcctgtctg cctccgtggg cgatagagtg      120

accatcacat gcagggctag ccagtccgtg tcctccgccg tggcttggta tcagcagaag      180

cccggcaagg cccctaagct gctgatctac tctgctagct ctctgtattc tggagtgcca      240

tccaggttct ccggaagccg gtctggaacc gactttaccc tgacaatctc cagcctgcag      300

ccagaggatt ttgctacata ctattgtcag cagtcctaca gccccttcac ctttggccag      360

ggcacaaagg tggagatcaa gcgtacggtg gctgcacctt ctgtgttcat cttccctcca      420

tctgatgagc agctgaagtc tggaaccgca tctgtcgtct gtctgctgaa caacttttac      480

cccagggagg ctaaggtcca atggaaggtg gacaacgccc tgcagtctgg taatagccag      540

gaaagcgtga ccgaacagga ttccaaggac tccacctact ccctgtcctc cacactgaca      600

ctgagcaaag ccgactatga aaagcacaaa gtgtatgcct gcgaggtcac tcatcagggc      660

ctgtccagcc ccgtgactaa aagctttaat aggggggagt gctgagcggc cgc             713


<210>  67
<211>  713
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain- 1099

<400>  67
atggtgctgc agacccaggt gttcatcagc ctgctgctgt ggatctctgg cgcctacggc       60

tccgacatcc agatgacaca gtctccatcc agcctgtctg cctccgtggg cgatagagtg      120

accatcacat gcagggctag ccagtccgtg tcctccgccg tggcttggta tcagcagaag      180

cccggcaagg cccctaagct gctgatctac tccgctagct ctctgtattc cggagtgcca      240

agcaggttct ccggaagccg gtctggaacc gactttaccc tgacaatctc cagcctgcag      300

cccgaggatt ttgccacata ctattgtcag cagcactacg ctctgttcac ctttggccag      360

ggcacaaagg tggagatcaa gcgtacggtg gctgcacctt ctgtgttcat cttccctcca      420

tctgatgagc agctgaagtc tggaaccgca tctgtcgtct gtctgctgaa caacttttac      480

cccagggagg ctaaggtcca atggaaggtg gacaacgccc tgcagtctgg taatagccag      540

gaaagcgtga ccgaacagga ttccaaggac tccacctact ccctgtcctc cacactgaca      600

ctgagcaaag ccgactatga aaagcacaaa gtgtatgcct gcgaggtcac tcatcagggc      660

ctgtccagcc ccgtgactaa aagctttaat aggggggagt gctgagcggc cgc             713


<210>  68
<211>  713
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain- 1100

<400>  68
atggtgctgc agacccaggt gttcatcagc ctgctgctgt ggatctctgg cgcctacggc       60

tccgacatcc agatgacaca gtctccatcc agcctgtctg cctccgtggg cgatagagtg      120

accatcacat gcagggctag ccagtccgtg tcctccgccg tggcttggta tcagcagaag      180

cccggcaagg cccctaagct gctgatctac tccgctagct ctctgtattc cggagtgcca      240

agcaggttct ccggaagccg gtctggaacc gactttaccc tgacaatctc cagcctgcag      300

cccgaggatt tcgctacata ctattgtcag cagcactacg gcctgatcac ctttggccag      360

ggcacaaagg tggagatcaa gcgtacggtg gctgcacctt ctgtgttcat cttccctcca      420

tctgatgagc agctgaagtc tggaaccgca tctgtcgtct gtctgctgaa caacttttac      480

cccagggagg ctaaggtcca atggaaggtg gacaacgccc tgcagtctgg taatagccag      540

gaaagcgtga ccgaacagga ttccaaggac tccacctact ccctgtcctc cacactgaca      600

ctgagcaaag ccgactatga aaagcacaaa gtgtatgcct gcgaggtcac tcatcagggc      660

ctgtccagcc ccgtgactaa aagctttaat aggggggagt gctgagcggc cgc             713


<210>  69
<211>  713
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain- 1101

<400>  69
atggtgctgc agacccaggt gttcatcagc ctgctgctgt ggatctctgg cgcctacggc       60

tccgacatcc agatgacaca gtctccttcc agcctgtctg cctccgtggg cgatagagtg      120

accatcacat gcagggctag ccagtccgtg tcctccgccg tggcttggta tcagcagaag      180

cccggcaagg cccctaagct gctgatctac tccgctagct ctctgtattc cggagtgcca      240

agcaggttct ccggaagccg gtctggaacc gactttaccc tgacaatctc cagcctgcag      300

ccagaggatt tcgccacata ctattgtcag caggctggct ggcccatcac ctttggccag      360

ggcacaaagg tggagatcaa gcgtacggtg gctgcacctt ctgtgttcat cttccctcca      420

tctgatgagc agctgaagtc tggaaccgca tctgtcgtct gtctgctgaa caacttttac      480

cccagggagg ctaaggtcca atggaaggtg gacaacgccc tgcagtctgg taatagccag      540

gaaagcgtga ccgaacagga ttccaaggac tccacctact ccctgtcctc cacactgaca      600

ctgagcaaag ccgactatga aaagcacaaa gtgtatgcct gcgaggtcac tcatcagggc      660

ctgtccagcc ccgtgactaa aagctttaat aggggggagt gctgagcggc cgc             713


<210>  70
<211>  713
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain- 1102

<400>  70
atggtgctgc agacccaggt gttcatcagc ctgctgctgt ggatctctgg cgcctacggc       60

tccgacatcc agatgacaca gtctccttcc agcctgtctg cctccgtggg cgatagagtg      120

accatcacat gcagggctag ccagtccgtg tcctccgccg tggcttggta tcagcagaag      180

cccggcaagg cccctaagct gctgatctac tccgctagct ctctgtattc cggagtgcca      240

agcaggttct ccggaagccg gtctggaacc gactttaccc tgacaatctc cagcctgcag      300

ccagaggatt ttgccacata ctattgtcag caggcttact cccccttcac ctttggccag      360

ggcacaaagg tggagatcaa gcgtacggtg gctgcacctt ctgtgttcat cttccctcca      420

tctgatgagc agctgaagtc tggaaccgca tctgtcgtct gtctgctgaa caacttttac      480

cccagggagg ctaaggtcca atggaaggtg gacaacgccc tgcagtctgg taatagccag      540

gaaagcgtga ccgaacagga ttccaaggac tccacctact ccctgtcctc cacactgaca      600

ctgagcaaag ccgactatga aaagcacaaa gtgtatgcct gcgaggtcac tcatcagggc      660

ctgtccagcc ccgtgactaa aagctttaat aggggggagt gctgagcggc cgc             713


<210>  71
<211>  716
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain- 1103

<400>  71
atggtgctgc agacccaggt gttcatcagc ctgctgctgt ggatctctgg cgcctacggc       60

tccgacatcc agatgacaca gtctccttcc agcctgtctg cctccgtggg cgatagagtg      120

accatcacat gcagggctag ccagtccgtg tcctccgccg tggcttggta tcagcagaag      180

cccggcaagg cccctaagct gctgatctac tccgctagct ctctgtattc cggagtgcca      240

agcaggttct ccggaagccg gtctggaacc gactttaccc tgacaatctc cagcctgcag      300

ccagaggatt tcgctacata ctattgtcag cagcactact cctatcccat cacctttggc      360

cagggcacaa aggtggagat caagcgtacg gtggctgcac cttctgtgtt catcttccct      420

ccatctgatg agcagctgaa gtctggaacc gcatctgtcg tctgtctgct gaacaacttt      480

taccccaggg aggctaaggt ccaatggaag gtggacaacg ccctgcagtc tggtaatagc      540

caggaaagcg tgaccgaaca ggattccaag gactccacct actccctgtc ctccacactg      600

acactgagca aagccgacta tgaaaagcac aaagtgtatg cctgcgaggt cactcatcag      660

ggcctgtcca gccccgtgac taaaagcttt aatagggggg agtgctgagc ggccgc          716


<210>  72
<211>  713
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain- 1104

<400>  72
atggtgctgc agacccaggt gttcatcagc ctgctgctgt ggatctctgg cgcctacggc       60

tccgacatcc agatgacaca gtctccatcc agcctgtctg cctccgtggg cgatagagtg      120

accatcacat gcagggctag ccagtccgtg tcctccgccg tggcttggta tcagcagaag      180

cccggcaagg cccctaagct gctgatctac tccgctagct ctctgtattc cggagtgcca      240

agcaggttct ccggaagccg gtctggaacc gactttaccc tgacaatctc cagcctgcag      300

cccgaggatt tcgctacata ctattgtcag caggcctacg ctctgatcac ctttggccag      360

ggcacaaagg tggagatcaa gcgtacggtg gctgcacctt ctgtgttcat cttccctcca      420

tctgatgagc agctgaagtc tggaaccgca tctgtcgtct gtctgctgaa caacttttac      480

cccagggagg ctaaggtcca atggaaggtg gacaacgccc tgcagtctgg taatagccag      540

gaaagcgtga ccgaacagga ttccaaggac tccacctact ccctgtcctc cacactgaca      600

ctgagcaaag ccgactatga aaagcacaaa gtgtatgcct gcgaggtcac tcatcagggc      660

ctgtccagcc ccgtgactaa aagctttaat aggggggagt gctgagcggc cgc             713


<210>  73
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  Repeat n times, where n is an integer of at least 1.

<400>  73

Gly Ser Gly Gly Ser 
1               5   


<210>  74
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  REPEAT
<222>  (1)..(4)
<223>  Repeat n times, where n is an integer of at least 1.

<400>  74

Gly Gly Gly Ser 
1               


<210>  75
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  Repeat n times, where n is an integer of at least 1.

<400>  75

Gly Gly Gly Gly Ser 
1               5   


<210>  76
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  76

Gly Gly Ser Gly 
1               


<210>  77
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  77

Gly Gly Ser Gly Gly 
1               5   


<210>  78
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  78

Gly Ser Gly Ser Gly 
1               5   


<210>  79
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  79

Gly Ser Gly Gly Gly 
1               5   


<210>  80
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  80

Gly Gly Gly Ser Gly 
1               5   


<210>  81
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  81

Gly Ser Ser Ser Gly 
1               5   


<210>  82
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  82

Gly Gly Gly Gly Ser 
1               5   


<210>  83
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  83

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  84
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  84
ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatct                       45


